R W Stam, M M van den Heuvel-Eibrink, M L den Boer, M E G Ebus, G E Janka-Schaub, J D Allen, R Pieters
Infants with acute lymphoblastic leukemia (ALL) are more resistant to chemotherapeutic drugs than older children with ALL, except for Ara-C. Drug resistance mechanisms in infant ALL, however, remain unknown. Possibly, multidrug resistance (MDR) proteins like P-glycoprotein, MDR-associated protein (MRP1), lung resistance-related protein (LRP/MVP) and the breast cancer resistance protein (BCRP) play a role. Accordingly, we measured the mRNA levels of these proteins in infants (n=13) and non-infants (n=13) with ALL, using quantitative RT-PCR...
January 2004: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K