keyword
https://read.qxmd.com/read/38502592/immunological-landscape-of-retinal-ischemia-reperfusion-injury-insights-into-resident-and-peripheral-immune-cell-responses
#21
REVIEW
Shan He, Cuiying Liu, Changhong Ren, Heng Zhao, Xuxiang Zhang
Retinal ischemia-reperfusion injury (RIRI) is a complex condition characterized by immune cell-mediated inflammation and consequent neuronal damage. This review delves into the immune response mechanisms in RIRI, particularly emphasizing the roles played by resident and peripheral immune cells. It highlights the pivotal role of microglia, the primary resident immune cells, in exacerbating neuroinflammation and neuronal damage through their activation and subsequent release of pro-inflammatory mediators. Additionally, the review explores the contributions of other glial cell types, such as astrocytes and Müller cells, in modulating the immune response within the retinal environment...
March 1, 2024: Aging and Disease
https://read.qxmd.com/read/38501043/trends-in-lower-extremity-artery-disease-repair-incidence-comorbidity-and-mortality-a-danish-nationwide-cohort-study-1996-2018
#22
JOURNAL ARTICLE
Anders Møller, Nikolaj Eldrup, Jørn Wetterslev, Dorthe Hellemann, Henning Bay Nielsen, Klaus Rostgaard, Henrik Hjalgrim, Ole Birger Pedersen
BACKGROUND: The prevalence of occlusive lower extremity artery disease (LEAD) is rising worldwide while European epidemiology data are scarce. We report incidence and mortality of LEAD repair in Denmark from 1996 through 2018, stratified on open aorto-iliac, open peripheral, and endovascular repair. METHODS: A nationwide cohort study of prospective data from population-based Danish registers covering 1996 to 2018. Comorbidity was assessed by Charlson's Comorbidity Index (CCI)...
2024: Vascular Health and Risk Management
https://read.qxmd.com/read/38498348/poly-adp-ribose-mediates-bioenergetic-defects-and-redox-imbalance-in-neurons-following-oxygen-and-glucose-deprivation
#23
JOURNAL ARTICLE
M Iqbal Hossain, Jun Hee Lee, Jean-Philippe Gagné, Junaid Khan, Guy G Poirier, Peter H King, Valina L Dawson, Ted M Dawson, Shaida A Andrabi
PARP-1 over-activation results in cell death via excessive PAR generation in different cell types, including neurons following brain ischemia. Glycolysis, mitochondrial function, and redox balance are key cellular processes altered in brain ischemia. Studies show that PAR generated after PARP-1 over-activation can bind hexokinase-1 (HK-1) and result in glycolytic defects and subsequent mitochondrial dysfunction. HK-1 is the neuronal hexokinase and catalyzes the first reaction of glycolysis, converting glucose to glucose-6-phosphate (G6P), a common substrate for glycolysis, and the pentose phosphate pathway (PPP)...
March 31, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38497953/arteriovenous-access-for-hemodialysis-a-review
#24
JOURNAL ARTICLE
Charmaine E Lok, Thomas S Huber, Ani Orchanian-Cheff, Dheeraj K Rajan
IMPORTANCE: Hemodialysis requires reliable vascular access to the patient's blood circulation, such as an arteriovenous access in the form of an autogenous arteriovenous fistula or nonautogenous arteriovenous graft. This Review addresses key issues associated with the construction and maintenance of hemodialysis arteriovenous access. OBSERVATIONS: All patients with kidney failure should have an individualized strategy (known as Patient Life-Plan, Access Needs, or PLAN) for kidney replacement therapy and dialysis access, including contingency plans for access failure...
March 18, 2024: JAMA
https://read.qxmd.com/read/38496475/an-ethologically-relevant-paradigm-to-assess-visual-contrast-sensitivity-in-rodents
#25
Juan S Calanni, Marcos L Aranda, Hernán H Dieguez, Damian Dorfman, Tiffany M Schmidt, Ruth E Rosenstein
In the animal kingdom, threat information is perceived mainly through vision. The subcortical visual pathway plays a critical role in the rapid processing of visual information-induced fear, and triggers a response. Looming-evoked behavior in rodents, mimicking response to aerial predators, allowed identify the neural circuitry underlying instinctive defensive behaviors; however, the influence of disk/background contrast on the looming-induced behavioral response has not been examined, either in rats or mice...
March 7, 2024: bioRxiv
https://read.qxmd.com/read/38494125/genetic-and-pharmacological-targeting-of-xbp1-alleviates-hepatic-ischemia-reperfusion-injury-by-enhancing-foxo1-dependent-mitophagy
#26
JOURNAL ARTICLE
Baicheng Kuang, Mengqin Wang, Hao Yan, Qin Jiang, Zhiheng Wang, Haiqiang Ni, Shuaiheng Hou, Xuan Peng, Shiqi Gu, Yuanyuan Zhao, Tongwen Ou, Nianqiao Gong
Hepatic ischemia reperfusion (I/R) injury is a common clinical complication. X-box binding protein 1 (XBP1), as a critical regulator of the endoplasmic reticulum stress, has been implicated in a variety of diseases. In this study, we aimed to investigate the effects and the underlying mechanism of XBP1 in the progression of hepatic I/R injury. Hepatocyte-specific XBP1 knockout mice, multiple viral delivery systems and specific pharmacological inhibitors were applied in vivo in a partial hepatic I/R injury mouse model and in vitro in a cell model of hypoxia-reoxygenation (H/R) injury...
March 15, 2024: Translational Research: the Journal of Laboratory and Clinical Medicine
https://read.qxmd.com/read/38493531/sex-disparities-in-cardiogenic-shock-insights-from-the-frenshock-registry
#27
JOURNAL ARTICLE
Stéphane Manzo-Silberman, Anne-Céline Martin, Florence Boissier, Caroline Hauw-Berlemont, Nadia Aissaoui, Nicolas Lamblin, François Roubille, Eric Bonnefoy, Laurent Bonello, Meyer Elbaz, Guillaume Schurtz, Olivier Morel, Guillaume Leurent, Bruno Levy, Bernard Jouve, Brahim Harbaoui, Gérald Vanzetto, Nicolas Combaret, Benoit Lattucca, Sébastien Champion, Pascal Lim, Cédric Bruel, Francis Schneider, Marie-France Seronde, Vincent Bataille, Edouard Gerbaud, Etienne Puymirat, Clément Delmas
BACKGROUND: Cardiogenic shock (CS) is the most severe form of acute heart failure. Discrepancies have been reported between sexes regarding delays, pathways and invasive strategies in CS complicating acute myocardial infarction. However, effect of sex on the prognosis of unselected CS remains controversial. OBJECTIVES: The aim was to analyze the impact of sex on aetiology, management and prognosis of CS. METHODS: The FRENSHOCK registry included all CS admitted in 49 French Intensive Care Units (ICU) and Intensive Cardiac Care Units (ICCU) between April and October 2016...
March 16, 2024: Journal of Critical Care
https://read.qxmd.com/read/38492177/systematic-review-of-literature-citing-the-ischemia-trial
#28
REVIEW
David J King, Christian Eskander, Jacob Ricci, David Gittess, Rushi Patel, Mitchell Bourne, Jeffery Budweg, David E Winchester
PURPOSE OF REVIEW: Optimal therapy for patients with chronic coronary artery disease (CCD) has long been a topic under investigation and a subject of debate. Seeking to clarify appropriate management, the International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) trial compared medical management versus coronary angiography for patients with stable ischemic heart disease. Its reception in the medical community has been met with both acclaim and criticism...
March 16, 2024: Current Cardiology Reports
https://read.qxmd.com/read/38491914/endovascular-therapy-for-vascular-graft-infection-after-multiple-bypass-surgeries-for-aorto-iliac-occlusive-disease
#29
JOURNAL ARTICLE
Kensuke Fujioka, Yuji Nishida, Yuya Eguchi, Takashi Fujita, Katsuharu Uchiyama, Manabu Fujimoto
BACKGROUND: Vascular graft infection is a very complex disease. Although complete excision of the infected grafts with extra-anatomic bypass or in situ reconstruction is a general treatment strategy, some concerns including reinfection in the new graft remain. CASE REPORT: An 88 year-old man presented to the hospital with abdominal swelling and bleeding. The patient had undergone revascularization for aorto-iliac occlusive disease twice in the past. The first procedure had been performed 15 years previously, with right ilio-femoral bypass grafting for right iliac artery occlusion and stent implantation for left iliac artery stenosis...
March 16, 2024: Vascular and Endovascular Surgery
https://read.qxmd.com/read/38491167/ca-2-oscillation-in-vascular-smooth-muscle-cells-control-myogenic-spontaneous-vasomotion-and-counteract-post-ischemic-no-reflow
#30
JOURNAL ARTICLE
Jinze Li, Yiyi Zhang, Dongdong Zhang, Wentao Wang, Huiqi Xie, Jiayu Ruan, Yuxiao Jin, Tingbo Li, Xuzhao Li, Bingrui Zhao, Xiaoxuan Zhang, Jiayi Lin, Hongjun Shi, Jie-Min Jia
Ischemic stroke produces the highest adult disability. Despite successful recanalization, no-reflow, or the futile restoration of the cerebral perfusion after ischemia, is a major cause of brain lesion expansion. However, the vascular mechanism underlying this hypoperfusion is largely unknown, and no approach is available to actively promote optimal reperfusion to treat no-reflow. Here, by combining two-photon laser scanning microscopy (2PLSM) and a mouse middle cerebral arteriolar occlusion (MCAO) model, we find myogenic vasomotion deficits correlated with post-ischemic cerebral circulation interruptions and no-reflow...
March 15, 2024: Communications Biology
https://read.qxmd.com/read/38489988/blood-flow-and-emboli-transport-patterns-during-venoarterial-extracorporeal-membrane-oxygenation-a-computational-fluid-dynamics-study
#31
JOURNAL ARTICLE
Mehrdad Khamooshi, Avishka Wickramarachchi, Tim Byrne, Michael Seman, David F Fletcher, Aidan Burrell, Shaun D Gregory
PROBLEM: Despite advances in Venoarterial Extracorporeal Membrane Oxygenation (VA-ECMO), a significant mortality rate persists due to complications. The non-physiological blood flow dynamics of VA-ECMO may lead to neurological complications and organ ischemia. Continuous retrograde high-flow oxygenated blood enters through a return cannula placed in the femoral artery which opposes the pulsatile deoxygenated blood ejected by the left ventricle (LV), which impacts upper body oxygenation and subsequent hyperoxemia...
March 11, 2024: Computers in Biology and Medicine
https://read.qxmd.com/read/38488011/b-cells-mediate-lung-ischemia-reperfusion-injury-by-recruiting-classical-monocytes-via-synergistic-b-cell-receptor-tlr4-signaling
#32
JOURNAL ARTICLE
Khashayar Farahnak, Yun Zhu Bai, Yuhei Yokoyama, Deniz B Morkan, Zhiyi Liu, Junedh M Amrute, Alejandro De Filippis Falcon, Yuriko Terada, Fuyi Liao, Wenjun Li, Hailey M Shepherd, Ramsey R Hachem, Varun Puri, Kory J Lavine, Andrew E Gelman, Ankit Bharat, Daniel Kreisel, Ruben G Nava
Ischemia/reperfusion injury-mediated (IRI-mediated) primary graft dysfunction (PGD) adversely affects both short- and long-term outcomes after lung transplantation, a procedure that remains the only treatment option for patients suffering from end-stage respiratory failure. While B cells are known to regulate adaptive immune responses, their role in lung IRI is not well understood. Here, we demonstrated by intravital imaging that B cells are rapidly recruited to injured lungs, where they extravasate into the parenchyma...
January 23, 2024: Journal of Clinical Investigation
https://read.qxmd.com/read/38487516/vascular-resistance-index-and-the-immediate-hemodynamic-success-of-lower-limb-distal-artery-revascularization
#33
JOURNAL ARTICLE
Rebecca Paes de Andrade Souza Caldas, Esdras Marques Lins, Gabriela de Oliveira Buril, Fernanda Appolônio Rocha, Emmanuelle Tenório Albuquerque Godoi Berenguer de Barros E Silva, Larissa Barbosa de Andrade, Camilla Lins da Cunha Cavalcanti, Guilherme Barros Alves de Carvalho
BACKGROUND: Revascularization surgery is used to attempt to restore blood flow to the foot in patients with critical ischemia (CI) caused by peripheral arterial occlusive disease of the lower limbs (LL). Ultrasonography with Doppler (USD) SAH emerged in recent years as a highly valuable method for planning this surgical intervention. OBJECTIVES: To evaluate the relationship between the resistance index (RI), measured with USD, and immediate hemodynamic success of LL revascularization surgery in patients with CI...
2024: Jornal Vascular Brasileiro
https://read.qxmd.com/read/38485879/prospective-observational-study-of-volatile-sedation-with-sevoflurane-after-aneurysmal-subarachnoid-hemorrhage-using-the-sedaconda-anesthetic-conserving-device
#34
JOURNAL ARTICLE
Jan Leppert, Jan Küchler, Andreas Wagner, Niclas Hinselmann, Claudia Ditz
BACKGROUND: Volatile sedation is still used with caution in patients with acute brain injury because of safety concerns. We analyzed the effects of sevoflurane sedation on systemic and cerebral parameters measured by multimodal neuromonitoring in patients after aneurysmal subarachnoid hemorrhage (aSAH) with normal baseline intracranial pressure (ICP). METHODS: In this prospective observational study, we analyzed a 12-h period before and after the switch from intravenous to volatile sedation with sevoflurane using the Sedaconda Anesthetic Conserving Device with a target Richmond Agitation Sedation Scale score of - 5 to - 4...
March 14, 2024: Neurocritical Care
https://read.qxmd.com/read/38479640/a-novel-foley-catheter-based-brain-retraction-method-for-the-interhemispheric-approach-technical-considerations-and-an-illustrative-video
#35
JOURNAL ARTICLE
Murat Zaimoglu, Elif Gökalp, Muhammet Enes Gurses, Omer Ozpiskin, Baran Can Alpergin, Ozan Tekneci, Umit Eroglu
BACKGROUND: Management of interhemispheric pathologies requires surgical intervention through a restricted anatomical corridor ensconced within critical cerebral structures. The use of retractors to facilitate operative access may cause damage to cerebral tissue. The development of an innovative retraction technique designed to alleviate cerebral damage in such cases is imperative. OBJECTIVE: In this study, we present a novel and gentle retraction method to facilitate the interhemispheric approach...
March 11, 2024: World Neurosurgery
https://read.qxmd.com/read/38469710/accuracy-of-maximal-acceleration-time-of-pedal-arteries-to-diagnose-critical-limb-ischemia
#36
JOURNAL ARTICLE
Jean-Eudes Trihan, Magali Croquette, Jeanne Hersant, Romain Prigent, Cedric Fontaine, Samir Henni, Damien Lanéelle
INTRODUCTION: Maximal acceleration time of distal arteries of the foot (ATmax ) is correlated to ankle-brachial index (ABI) and toe-brachial index (TBI), and seems very promising in diagnosing severe peripheral artery disease (PAD) and especially critical limb-threatening ischemia (CLTI). Our goal was to confirm the cut-off value of 215 ms to predict a toe pressure (TP) ⩽ 30 mmHg. METHODS: A 4-month retrospective study was conducted on patients addressed for suspicion of PAD...
March 12, 2024: Vascular Medicine
https://read.qxmd.com/read/38468351/nonketotic-hyperglycemia-hemichorea-and-hemiballismus-a-case-report
#37
JOURNAL ARTICLE
Abhishek Dixit
BACKGROUND: Diabetic striatopathy, also known as hyperglycemic hemichorea-hemiballismus, is a rare movement disorder associated with nonketotic hyperglycemia in patients with poorly controlled diabetes mellitus. The pathophysiology is not fully elucidated but may involve hyperviscosity, ischemia, and alterations in basal ganglia neurotransmitters. CASE PRESENTATION: We present a case of a 64-year-old Asian female patient with longstanding poorly controlled type 2 diabetes mellitus who developed abrupt-onset right-sided hemichorea-hemiballismus...
March 12, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38466560/type-i-interferon-signalling-and-ischemic-stroke-mechanisms-and-therapeutic-potentials
#38
REVIEW
Pan Cui, Bo Song, Zongping Xia, Yuming Xu
Type I interferon (IFN-I) signalling is intricately involved in the pathogenesis of multiple infectious diseases, autoimmune diseases, and neurological diseases. Acute ischemic stroke provokes overactivation of IFN-I signalling within the injured brain, particularly in microglia. Following cerebral ischemia, damage-associated molecular patterns (DAMPs) released from injured neural cells elicit marked proinflammatory episodes within minutes. Among these, self-nucleic acids, including nuclear DNA and mitochondrial DNA (mtDNA), have been recognized as a critical alarm signal to fan the flames of neuroinflammation, predominantly via inducing IFN-I signalling activation in microglia...
March 11, 2024: Translational Stroke Research
https://read.qxmd.com/read/38466505/platelet-derived-microvesicles-mediate-cardiomyocyte-ferroptosis-by-transferring-acsl1-during-acute-myocardial-infarction
#39
JOURNAL ARTICLE
Yunfeng Zhao, Rui Cui, Ran Du, Chunmei Song, Fei Xie, Lin Ren, Junquan Li
Acute myocardial infarction (AMI) is one of the critical health conditions often caused by the rupture of unstable coronary artery plaque, triggering a series of events, such as platelet activation, thrombus formation, coronary artery blockage, lasted severe ischemia, and hypoxia in cardiomyocytes, and culminating in cell death. Platelet-derived microvesicles (PMVs) act as intermediates for cellular communication. Nevertheless, the role of PMVs in myocardial infarction remains unclear. Initially, AMI-related messenger ribose nucleic acid (mRNA) and micro RNA (miRNA) datasets from the Gene Expression Omnibus (GEO) database were analyzed, specifically focusing on the expressed genes associated with Ferroptosis...
March 11, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38463344/don-t-forget-emergency-surgery-lessons-to-learn-from-elective-indocyanine-green-guided-gastrointestinal-interventions
#40
EDITORIAL
Davina Perini, Jacopo Martellucci
Fluorescence-based imaging has found application in several fields of elective surgery, but there is still a lack of evidence in the literature about its use in the emergency setting. Clinical trials have consistently shown that indocyanine green (ICG)-guided surgery can dramatically reduce the risk of postoperative complications, length of in-hospital stay and total healthcare costs in the elective setting. It is well-known that emergency surgery has a higher complication rate than its elective counterpart, therefore an impelling need for research studies to explore, validate and develop this issue has been highlighted...
February 27, 2024: World Journal of Gastrointestinal Surgery
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