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Critical ischemia

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https://www.readbyqxmd.com/read/29663107/the-serca2-a-gatekeeper-of-neuronal-calcium-homeostasis-in-the-brain
#1
REVIEW
Aikaterini Britzolaki, Joseph Saurine, Emily Flaherty, Connor Thelen, Pothitos M Pitychoutis
Calcium (Ca2+ ) ions are prominent cell signaling regulators that carry information for a variety of cellular processes and are critical for neuronal survival and function. Furthermore, Ca2+ acts as a prominent second messenger that modulates divergent intracellular cascades in the nerve cells. Therefore, nerve cells have developed intricate Ca2+ signaling pathways to couple the Ca2+ signal to their biochemical machinery. Notably, intracellular Ca2+ homeostasis greatly relies on the rapid redistribution of Ca2+ ions into the diverse subcellular organelles which serve as Ca2+ stores, including the endoplasmic reticulum (ER)...
April 16, 2018: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/29661987/review-of-the-latest-percutaneous-devices-in-critical-limb-ischemia
#2
REVIEW
Leila Haghighat, Sophia Elissa Altin, Robert R Attaran, Carlos Mena-Hurtado, Christopher J Regan
Critical limb ischemia (CLI) is a terminal stage of peripheral arterial disease that, in the absence of intervention, may lead to lower extremity amputation or death. Endovascular interventions have become a first-line approach to the management of CLI and have advanced considerably within the past decade. This review summarizes the types of percutaneous devices and the techniques that are available for the management of CLI and the data supporting their use. These include devices that establish and maintain vessel patency, including percutaneous transluminal angioplasty, drug-coated balloons, bare metal stents, drug-eluting stents, bioresorbable vascular scaffolds, and atherectomy; devices that provide protection from embolization; and, cell-based therapies...
April 14, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29661023/tak1-mediates-apoptosis-via-p38-involve-in-ischemia-induced-renal-fibrosis
#3
Jun Zhou, Jiying Zhong, Zhenxing Huang, Meijuan Liao, Sen Lin, Jia Chen, Hongtao Chen
Renal fibrosis is a common and characteristic symptom of chronic kidney disease (CKD). However, the molecular mechanisms of renal fibrosis remain elusive. Ischemia injury, as a major cause of AKI, deserves more attention in order to improve the knowledge of AKI-induced fibrosis. Transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1) interacts directly with TGF-β, which play a critical role in the progression of fibrosis. Therefore, the present study aimed to investigate the role of TAK1 in the pathogenesis of ischemia-induced renal fibrosis...
April 16, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29658434/bone-marrow-derived-cells-trafficking-to-the-oviduct-effect-of-ischemia-reperfusion-injury
#4
Cagdas Sahin, Ramanaiah Mamillapalli, Hugh S Taylor
The oviduct/fallopian tube is a crucial organ in the mammalian reproductive tract; it plays a critical role in gamete transportation and early embryo development. In women, torsion of the fallopian tubes can cause ischemia and reperfusion (IR) injury. In this study, we tested the effect of this injury on recruitment of bone marrow-derived cells (BMDCs) to the oviducts of reproductive age female mice. Bone marrow-derived cells were collected from ubiquitin-green fluorescent protein-positive male mice and transplanted into wild-type female mice...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29657720/promising-novel-therapy-with-hydrogen-gas-for-emergency-and-critical-care-medicine
#5
REVIEW
Motoaki Sano, Masaru Suzuki, Koichiro Homma, Kei Hayashida, Tomoyoshi Tamura, Tadashi Matsuoka, Yoshinori Katsumata, Shuko Onuki, Junichi Sasaki
It has been reported that hydrogen gas exerts a therapeutic effect in a wide range of disease conditions, from acute illness such as ischemia-reperfusion injury, shock, and damage healing to chronic illness such as metabolic syndrome, rheumatoid arthritis, and neurodegenerative diseases. Antioxidant and anti-inflammatory properties of hydrogen gas have been proposed, but the molecular target of hydrogen gas has not been identified. We established the Center for Molecular Hydrogen Medicine to promote non-clinical and clinical research on the medical use of hydrogen gas through industry-university collaboration and to obtain regulatory approval of hydrogen gas and hydrogen medical devices (http://www...
April 2018: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29656608/combined-therapy-for-critical-limb-ischemia-biomimetic-plga-microcarriers-potentiates-the-pro-angiogenic-effect-of-adipose-tissue-stromal-vascular-fraction-cells
#6
Laurence Hoareau, Florian Fouchet, Cynthia Planesse, Sophie Mirbeau, Laurence Sindji, Emmanuel Delay, Régis Roche, Claudia N Montero-Menei, Franck Festy
We propose a regenerative solution in the treatment of critical limb ischemia. Poly-lactic/glycolic acid (PLGA) microcarriers were prepared and coated with laminin to be sterilized through γ-irradiation of 25 kGy at low temperature. Stromal vascular fraction (SVF) cells were extracted through enzymatic digestion of adipose tissue. Streptozotocin-induced diabetic mice underwent arteriotomy and received an administration of SVF cells combined or not with biomimetic microcarriers. Functional evaluation of the ischemic limb was then reported and tissue reperfusion was evaluated through fluorescence molecular tomography (FMT)...
April 14, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29650705/outcomes-of-peripheral-vascular-interventions-in-select-patients-with-lower-extremity-acute-limb-ischemia
#7
Elica Inagaki, Alik Farber, Jeffrey A Kalish, Mohammad H Eslami, Jeffrey J Siracuse, Robert T Eberhardt, Denis V Rybin, Gheorghe Doros, Naomi M Hamburg
BACKGROUND: Contemporary data on patients presenting with acute limb ischemia (ALI), who are selected for treatment with endovascular peripheral vascular interventions (PVI), are limited. Our study examined outcomes following endovascular PVI in patients with ALI by comparing with patients treated for chronic critical limb ischemia using a regional quality improvement registry. METHODS AND RESULTS: Of the 11 035 patients in the Vascular Study Group of New England PVI database (2010-2014), we identified 365 patients treated for lower extremity ALI who were 5:1 frequency matched (by procedure year and arterial segments treated) to 1808 patients treated for critical limb ischemia...
April 12, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29643698/real-world-comparison-of-drug-eluting-and-bare-metal-stents-in-superficial-femoral-artery-occlusive-disease-with-trans-atlantic-intersociety-consensus-b-lesions-a-2-year-single-institute-study
#8
Fan-Chieh Meng, Po-Lin Chen, Chiu-Yang Lee, Chun-Che Shih, I-Ming Chen
Background: Endovascular stenting has surpassed bypass surgery to become the first-line treatment for superficial femoral artery (SFA) occlusive disease, and various types of stents including bare-metal stents (BMSs), covered stents, and drug-eluting stents (DESs), have been approved for treatment. This retrospective, single-institute study compared the short-term, real-world outcomes of BMSs and DESs for treating SFA occlusive disease. Methods: A retrospective chart review was used to enroll 94 patients who received a DES (n = 24) or BMS (n = 70) between 2009 and 2014...
March 2018: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29643256/critical-role-of-flavin-and-glutathione-in-complex-i-mediated-bioenergetic-failure-in-brain-ischemia-reperfusion-injury
#9
Anja Kahl, Anna Stepanova, Csaba Konrad, Corey Anderson, Giovanni Manfredi, Ping Zhou, Costantino Iadecola, Alexander Galkin
BACKGROUND AND PURPOSE: Ischemic brain injury is characterized by 2 temporally distinct but interrelated phases: ischemia (primary energy failure) and reperfusion (secondary energy failure). Loss of cerebral blood flow leads to decreased oxygen levels and energy crisis in the ischemic area, initiating a sequence of pathophysiological events that after reoxygenation lead to ischemia/reperfusion (I/R) brain damage. Mitochondrial impairment and oxidative stress are known to be early events in I/R injury...
April 11, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29628469/calcified-nodules-projecting-into-the-popliteal-artery-successfully-treated-through-the-use-of-myocardial-biopsy-forceps
#10
Takenobu Shimada, Tsuyoshi Goto, Shunsuke Kubo, Seiji Habara, Hiroyuki Tanaka, Kazushige Kadota
A 69-year-old man on maintenance dialysis underwent endovascular therapy for a refractory wound due to critical limb ischemia in the popliteal and below-knee arteries. Because of bulky calcified nodules projecting into the popliteal artery, conventional balloon angioplasty alone did not seem to provide a sufficient lumen area, and we ablated the calcified nodules by using myocardial biopsy forceps for lesion preparation. Under roadmap guidance, we repeated ablation 39 times to carefully tear off the bulky calcified nodules, and subsequently performed balloon angioplasty in the popliteal artery...
April 6, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29624520/inhibition-of-microrna-429-attenuates-oxygen-glucose-deprivation-reoxygenation-induced-neuronal-injury-by-promoting-expression-of-gata-binding-protein-4
#11
Jie Xiao, Ranran Kong, Jingye Hu
MicroRNAs (miRNAs) have been documented as critical regulators in ischemia/reperfusion-induced neuronal death. A better understanding of miRNA-mediated molecular mechanisms in ischemia/reperfusion-induced neuronal death may provide therapeutic targets for cerebral ischemia/reperfusion injury. A growing body of evidence suggests that miR-429 is a apoptosis-related miRNA that is also induced by hypoxia. However, whether miR-429 is involved in regulating neuronal apoptosis during cerebral ischemia/reperfusion injury remains unclear...
April 5, 2018: Neuroreport
https://www.readbyqxmd.com/read/29622397/the-route-and-timing-of-hydrogen-sulfide-therapy-critically-impacts-intestinal-recovery-following-ischemia-and-reperfusion-injury
#12
Amanda R Jensen, Natalie A Drucker, Jan P Te Winkel, Michael J Ferkowicz, Troy A Markel
PURPOSE: Hydrogen sulfide (H2 S) has many beneficial properties and may serve as a novel treatment in patients suffering from intestinal ischemia-reperfusion injury (I/R). The purpose of this study was to examine the method of delivery and timing of administration of H2 S for intestinal therapy during ischemic injury. We hypothesized that 1) route of administration of hydrogen sulfide would impact intestinal recovery following acute mesenteric ischemia and 2) preischemic H2 S conditioning using the optimal mode of administration as determined above would provide superior protection compared to postischemic application...
March 6, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29619573/-idiopathic-systemic-capillary-leak-syndrome-clarkson-disease-a-rare-cause-of-recurrent-life-threatening-edema
#13
REVIEW
S Dasdelen, S-O Grebe
This case report describes the episodic occurrence of severe generalized edema in a young female patient, who developed hypertension with a massive hemoconcentration (hematocrit >0.5, hemoglobin >20g/dl) and hypoalbuminemia during the course of these acute disease phases. After the first two disease exacerbations were overcome, there was a complete regression of symptoms. After a long symptom-free interval, a new exacerbation occurred as a result of which critical organ ischemia occurred due to the severe hypotension and massive edema...
April 4, 2018: Der Internist
https://www.readbyqxmd.com/read/29618972/an-inflammation-centric-view-of-neurological-disease-beyond-the-neuron
#14
REVIEW
Stephen D Skaper, Laura Facci, Morena Zusso, Pietro Giusti
Inflammation is a complex biological response fundamental to how the body deals with injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a normally beneficial acute inflammatory response, chronic inflammation can lead to tissue damage and ultimately its destruction, and often results from an inappropriate immune response. Inflammation in the nervous system ("neuroinflammation"), especially when prolonged, can be particularly injurious. While inflammation per se may not cause disease, it contributes importantly to disease pathogenesis across both the peripheral (neuropathic pain, fibromyalgia) and central [e...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29618155/von-willebrand-factor-aggravates-hepatic-ischemia-reperfusion-injury-by-promoting-neutrophil-recruitment-in-mice
#15
Yasuyuki Urisono, Asuka Sakata, Hideto Matsui, Shogo Kasuda, Shiro Ono, Kiyomi Yoshimoto, Kenji Nishio, Masayuki Sho, Masashi Akiyama, Toshiyuki Miyata, Kazuo Okuchi, Satoshi Nishimura, Mitsuhiko Sugimoto
Hepatic ischaemia-reperfusion (I/R) injury is a serious liver damage that critically influences the clinical outcome of liver surgery or transplantation. Since recent studies indicated the critical involvement of von Willebrand factor (VWF) in reperfusion injuries of brain and myocardium, we hypothesized that VWF-dependent thrombotic or inflammatory responses also play a role in hepatic I/R injury. Using a mouse model of hepatic I/R injury, we explored the functional relevance of the VWF-ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) axis in this pathologic condition...
April 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29615358/outcomes-of-infrageniculate-retrograde-versus-transfemoral-access-for-endovascular-intervention-for-chronic-lower-extremity-ischemia
#16
Ashraf G Taha, Adham N Abou Ali, George Al-Khoury, Michael J Singh, Michel S Makaroun, Efthymios D Avgerinos, Rabih A Chaer
OBJECTIVE: Retrograde infrageniculate access is an alternative treatment strategy for patients who have failed to respond to antegrade endovascular intervention. This study compares the outcomes of infrageniculate retrograde arterial access with the conventional transfemoral access for the endovascular management of chronic lower extremity ischemia. METHODS: This was a retrospective single-center review of retrograde endovascular intervention (REI) from 2012 to 2016...
March 31, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29615349/assessment-of-extracellular-matrix-related-biomarkers-in-patients-with-lower-extremity-artery-disease
#17
Anna Hernández-Aguilera, Signe Holm Nielsen, Cristina Bonache, Salvador Fernández-Arroyo, Vicente Martín-Paredero, Montserrat Fibla, Morten A Karsdal, Federica Genovese, Javier A Menendez, Jordi Camps, Jorge Joven
BACKGROUND: The prevalence of lower extremity artery disease (LEAD) is high (20%-25%) in the population older than 65 years, but patients are seldom identified until the disease is advanced. Circulating markers of disease activity might provide patients with a key opportunity for timely treatment. We tested the hypothesis that measuring blood-specific fragments generated during degradation of the extracellular matrix (ECM) could provide further insight into the pathophysiologic mechanism of arterial remodeling...
March 31, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29611441/juvenile-cerebral-ischemia-reveals-age-dependent-bdnf-trkb-signaling-changes-novel-mechanism-of-recovery-and-therapeutic-intervention
#18
Robert M Dietz, James E Orfila, Krista M Rodgers, Olivia P Patsos, Guiying Deng, Nicholas Chalmers, Nidia Quillinan, Richard J Traystman, Paco S Herson
Global ischemia in childhood often leads to poor neurologic outcomes, including learning and memory deficits. Using our novel model of childhood cardiac arrest/cardiopulmonary resuscitation (CA/CPR), we investigate the mechanism of ischemia-induced cognitive deficits and recovery. Memory is impaired seven days after juvenile CA/CPR and completely recovers by 30 days. Consistent with this remarkable recovery not observed in adults, hippocampal long-term potentiation (LTP) is impaired 7-14 days after CA/CPR, recovering by 30 days...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29606570/femoral-artery-transposition-is-a-safe-and-durable-option-for-the-treatment-of-popliteal-artery-aneurysms
#19
Gaël Bounkong, Jean-Michel Davaine, Philippe Tresson, Lucie Derycke, Nicolas Kagan, Thibault Couture, James Lawton, Mahine Kashi, Julien Gaudric, Laurent Chiche, Fabien Koskas
OBJECTIVE: A suitable ipsilateral great saphenous vein (GSV) autograft is widely considered the best material for arterial reconstruction of a popliteal artery aneurysm (PAA). There are, however, cases in which such a GSV is absent, diseased, or of too small diameter for this use. Alternatives to GSV are synthetic conduits, but with a reduced long-term patency, in particular for infragenicular bypass; other venous autografts of marginal use; and stent grafts still in the first stages of their evaluation...
March 29, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29602580/effects-of-chronic-kidney-disease-on-clinical-outcomes-in-patients-with-peripheral-artery-disease-undergoing-endovascular-treatment-analysis-from-the-k-vis-ella-registry
#20
Hyung Oh Kim, Jae-Min Kim, Jong Shin Woo, Donghoon Choi, Young-Guk Ko, Chul-Min Ahn, Seung-Whan Lee, Jae-Hwan Lee, Seung-Hyuk Choi, Cheol Woong Yu, Pil-Ki Min, Chang-Hwan Yoon, In-Ho Chae, Sang-Rok Lee, Yoon Seok Koh, Weon Kim
OBJECTIVES: Chronic kidney disease (CKD) is a risk factor for peripheral artery disease (PAD), but the impact of CKD in PAD patients who received endovascular treatment (EVT) is not well studied. Aim of this study is to clarify the impact of CKD in patients with PAD in real EVT era. METHODS: Using the Korean Vascular Intervention Society (K-VIS) endovascular therapy in lower limb artery disease registry (ELLA) registry, we analyzed 3434 patients who underwent EVT...
March 23, 2018: International Journal of Cardiology
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