keyword
Keywords Lung drug deposition fluoresce...

Lung drug deposition fluorescence imaging

https://read.qxmd.com/read/37843890/heterogenous-intrapulmonary-distribution-of-aerosolized-model-compounds-in-mice-with-bleomycin-induced-pulmonary-fibrosis
#1
JOURNAL ARTICLE
Kohei Togami, Yukimune Kanehira, Yuki Yumita, Hiroaki Ozaki, Rui Wang, Hitoshi Tada, Sumio Chono
Background: A distinctive pathological feature of idiopathic pulmonary fibrosis (IPF) is the aberrant accumulation of extracellular matrix components in the alveoli in abnormal remodeling and reconstruction following scarring of the alveolar structure. The current antifibrotic agents used for IPF therapy frequently result in systemic side effects because these agents are distributed, through the blood, to many different tissues after oral administration. In contrast to oral administration, the intrapulmonary administration of aerosolized drugs is believed to be an efficient method for their direct delivery to the focus sites in the lungs...
October 16, 2023: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://read.qxmd.com/read/37830402/gsh-activatable-camptothecin-prodrug-loaded-gold-nanostars-coated-with-hyaluronic-acid-for-targeted-breast-cancer-therapy-via-multiple-radiosensitization-strategies
#2
JOURNAL ARTICLE
Yingke Hou, Bin Sun, Rongtian Li, Wei Meng, Wenhua Zhang, Nuan Jia, Ming Chen, Jinxiang Chen, Xiaoyan Tang
Breast cancer has overtaken lung cancer to rank as the top malignant tumor in terms of incidence. Herein, a gold nanostar (denoted as AuNS) is used for loading disulfide-coupled camptothecin-fluorophore prodrugs (denoted as CPT-SS-FL) to form a nanocomposite of AuNS@CPT-SS-FL (denoted as AS), which, in turn, is further encapsulated with hyaluronic acid (HA) to give the final nanoplatform of AuNS@CPT-SS-FL@HA (denoted as ASH). ASH effectively carries the prodrug and targets the CD44 receptor on the surface of tumor cells...
October 13, 2023: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/37691540/design-of-a-multilayer-lung-chip-with-multigenerational-alveolar-ducts-to-investigate-the-inhaled-particle-deposition
#3
JOURNAL ARTICLE
Yan Qiu, Chao Lu, Fubing Bao, Guoqing Hu
We present the development and application of a multilayer microfluidic lung chip designed to accurately replicate the human respiratory bronchi, providing an innovative platform for controlled particle deposition in the lung. By employing a quantitative control method of fluid velocity through the deformation of an elastic PDMS membrane, this platform mimics the passive breathing process in humans and allows for precise simulation of the respiration cycle. We utilized time-lapse photography of fluorescent particles in a water/glycerol solution to qualitatively observe fluid morphology in the channel, while a chip-aerosol exposure device combined with microscopy imaging was employed to visualise aerosol deposition...
September 11, 2023: Lab on a Chip
https://read.qxmd.com/read/37011838/can-targeted-nanoparticles-distinguish-cancer-metastasis-from-inflammation
#4
JOURNAL ARTICLE
Andrew S Choi, Taylor J Moon, Walid Abuhashim, Anubhuti Bhalotia, Huikang Qian, Kai E Paulsen, Morgan Lorkowski, Crystal Ndamira, Ramamurthy Gopalakrishnan, Animesha Krishnamurthy, William P Schiemann, Efstathios Karathanasis
Targeting ligands have been widely used to increase the intratumoral accumulation of nanoparticles and their uptake by cancer cells. However, these ligands aim at targets that are often also upregulated in inflamed tissues. Here, we assessed the ability of targeted nanoparticles to distinguish metastatic cancer from sites of inflammation. Using common targeting ligands and a 60-nm liposome as a representative nanoparticle, we generated three targeted nanoparticle (NP) variants that targeted either fibronectin, folate, or αv β3 integrin, whose deposition was compared against that of standard untargeted NP...
April 1, 2023: Journal of Controlled Release
https://read.qxmd.com/read/35513950/delayed-alveolar-clearance-of-nanoparticles-through-control-of-coating-composition-and-interaction-with-lung-surfactant-protein-a
#5
JOURNAL ARTICLE
Susana Carregal-Romero, Hugo Groult, Olga Cañadas, Noelia A-Gonzalez, Ana Victoria Lechuga-Vieco, Belén García-Fojeda, Fernando Herranz, Juan Pellico, Andrés Hidalgo, Cristina Casals, Jesús Ruiz-Cabello
The coating composition of nanomedicines is one of the main features in determining the medicines' fate, clearance, and immunoresponse in the body. To highlight the coatings' impact in pulmonary administration, two micellar superparamagnetic iron oxide nanoparticles (SPION) were compared. These nanoparticles are similar in size and charge but have different coatings: either phosphatidylcholine (PC-SPION) or bovine serum albumin (BSA-SPION). The aim of the study was to increase the understanding of the nano-bio interaction with the cellular and non-cellular components of the lung and underline valuable coatings either for local lung-targeted drug delivery in theranostic application or patient-friendly route systemic administration...
November 14, 2021: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/33464839/inhalable-lactoferrin-chondroitin-functionalized-monoolein-nanocomposites-for-localized-lung-cancer-targeting
#6
JOURNAL ARTICLE
Hadeer M Abdelaziz, Ahmed O Elzoghby, Maged W Helmy, Elsayeda-Zeinab A Abdelfattah, Jia-You Fang, Magda W Samaha, May S Freag
Localized drug delivery to lung cancer can overcome the limitations of systemic nanocarriers including low drug amounts reaching lung tissues and severe off-target toxicity. The current work presented novel inhalable nanocomposites as noninvasive platforms for lung cancer therapy. Nanoparticulate liquid crystals (LCNPs) based on monoolein were developed for synergistic co-encapsulation of the cytotoxic chemotherapeutic drug, pemetrexed, and the phytoherbal drug, resveratrol (PEM-RES-LCNPs). For active tumor targeting, lactoferrin (LF) and chondroitin sulfate (CS), natural polymers with intrinsic tumor-targeting capabilities, were exploited to functionalize the surface of LCNPs using a layer-by-layer (LbL) self-assembly approach...
February 10, 2020: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/33354510/a-homogenous-nanoporous-pulmonary-drug-delivery-system-based-on-metal-organic-frameworks-with-fine-aerosolization-performance-and-good-compatibility
#7
JOURNAL ARTICLE
Yixian Zhou, Boyi Niu, Biyuan Wu, Sulan Luo, Jintao Fu, Yiting Zhao, Guilan Quan, Xin Pan, Chuanbin Wu
Pulmonary drug delivery has attracted increasing attention in biomedicine, and porous particles can effectively enhance the aerosolization performance and bioavailability of drugs. However, the existing methods for preparing porous particles using porogens have several drawbacks, such as the inhomogeneous and uncontrollable pores, drug leakage, and high risk of fragmentation. In this study, a series of cyclodextrin-based metal-organic framework (CD-MOF) particles containing homogenous nanopores were delicately engineered without porogens...
December 2020: Acta Pharmaceutica Sinica. B
https://read.qxmd.com/read/33009655/a-dry-powder-inhalable-formulation-of-salvianolic-acids-for-the-treatment-of-pulmonary-fibrosis-safety-lung-deposition-and-pharmacokinetic-study
#8
JOURNAL ARTICLE
Linxia Jiang, Yijun Li, Jiaqi Yu, Jianhong Wang, Jiarui Ju, Jundong Dai
Salvianolic acids (SAL), the main bioactive component extracted from Salvia miltiorrhiza, is a natural product with a reported anti-pulmonary fibrosis (PF) effect. SAL is commonly administrated orally; however, it has a low oral bioavailability (less than 5%). The objective of this work was to develop a new dry powder inhalable formulation intended to facilitate the access of SAL to the target place. We prepared the new SAL powder formulation containing L-arginine and 2% of lecithin using the ball milling technique...
October 3, 2020: Drug Delivery and Translational Research
https://read.qxmd.com/read/32291520/promoted-antitumor-activity-of-myricetin-against-lung-carcinoma-via-nanoencapsulated-phospholipid-complex-in-respirable-microparticles
#9
JOURNAL ARTICLE
Noha Nafee, Dina M Gaber, Ahmed O Elzoghby, Maged W Helmy, Osama Y Abdallah
PURPOSE: Myricetin (MYR) flavonoid is well-recognized for its antioxidant, anti-inflammatory and anti-tumor potential. Introducing nanomedicine was the ultimate resort to solve the imperfections of this nutraceutical, namely solubility, stability and delivery issues. The study, thus, aims at developing inhalable microparticles comprising MYR solid lipid nanoparticles (SLNs) for lung cancer therapy. METHODS: A two-step preparation procedure starting with complexation of MYR with the phospholipid Lipoid-S100, followed by nanoencapsulation in Gelucire-based, surfactant-free SLNs was developed...
April 14, 2020: Pharmaceutical Research
https://read.qxmd.com/read/31664837/in-vivo-brain-delivery-and-brain-deposition-of-proteins-with-various-sizes
#10
JOURNAL ARTICLE
Kavisha R Ulapane, Brian M Kopec, Teruna J Siahaan
It is very challenging to develop protein drugs for the treatment of brain diseases; this is due to the difficulty in delivering them into the brain because of the blood-brain barrier (BBB). Thus, alternative delivery methods need further exploration for brain delivery of proteins to diagnose and treat brain diseases. Previously, ADTC5 and HAV6 peptides have been shown to enhance the in vivo brain delivery of small- and medium-size molecules across the BBB. This study was carried out to evaluate ability of ADTC5 and HAV6 peptides to enhance delivery of proteins of various sizes, such as 15 kDa lysozyme, 65 kDa albumin, 150 kDa IgG mAb, and 220 kDa fibronectin, into the brains of C57BL/6 mice...
October 30, 2019: Molecular Pharmaceutics
https://read.qxmd.com/read/31639283/multimodal-precision-imaging-of-pulmonary-nanoparticle-delivery-in-mice-dynamics-of-application-spatial-distribution-and-dosimetry
#11
JOURNAL ARTICLE
Lin Yang, Regine Gradl, Martin Dierolf, Winfried Möller, David Kutschke, Annette Feuchtinger, Lorenz Hehn, Martin Donnelley, Benedikt Günther, Klaus Achterhold, Axel Walch, Tobias Stoeger, Daniel Razansky, Franz Pfeiffer, Kaye S Morgan, Otmar Schmid
Targeted delivery of nanomedicine/nanoparticles (NM/NPs) to the site of disease (e.g., the tumor or lung injury) is of vital importance for improved therapeutic efficacy. Multimodal imaging platforms provide powerful tools for monitoring delivery and tissue distribution of drugs and NM/NPs. This study introduces a preclinical imaging platform combining X-ray (two modes) and fluorescence imaging (three modes) techniques for time-resolved in vivo and spatially resolved ex vivo visualization of mouse lungs during pulmonary NP delivery...
October 22, 2019: Small
https://read.qxmd.com/read/31593534/lopinavir-loaded-spray-dried-liposomes-with-penetration-enhancers-for-cytotoxic-activity
#12
JOURNAL ARTICLE
Mithun Maniyar, Ashok Chandak, Chandrakant Kokare
OBJECTIVE: HIV protease inhibitors (HIV-PI) are the drugs utilized for the treatment of HIV. However, its effectiveness is limited due to lack of bioavailability and need to co-administer with another drug. In this study single lopinavir (LPV) loaded phospholipid vesicles were prepared by the spray-drying method. LPV-loaded spray-dried powder (L-SDP) was transformed into vesicles and then entrapped in a cream base with peppermint and olive oil. METHOD: Attenuated total reflectance Fourier transform infrared (ATR-FTIR) membrane fluidity study used to predict oil's effect on skin...
October 8, 2019: Infectious Disorders Drug Targets
https://read.qxmd.com/read/31254554/visualizing-treatment-delivery-and-deposition-in-mouse-lungs-using-in-vivo-x-ray-imaging
#13
JOURNAL ARTICLE
Regine Gradl, Martin Dierolf, Lin Yang, Lorenz Hehn, Benedikt Günther, Winfried Möller, David Kutschke, Tobias Stoeger, Bernhard Gleich, Klaus Achterhold, Martin Donnelley, Franz Pfeiffer, Otmar Schmid, Kaye Susannah Morgan
The complexity of lung diseases makes pre-clinical in vivo respiratory research in mouse lungs of great importance for a better understanding of physiology and therapeutic effects. Synchrotron-based imaging has been successfully applied to lung research studies, however longitudinal studies can be difficult to perform due to limited facility access. Laboratory-based x-ray sources, such as inverse Compton x-ray sources, remove this access limitation and opens up new possibilities for pre-clinical small-animal lung research at high spatial and temporal resolution...
August 10, 2019: Journal of Controlled Release
https://read.qxmd.com/read/30981874/nanoporous-cd-mof-particles-with-uniform-and-inhalable-size-for-pulmonary-delivery-of-budesonide
#14
JOURNAL ARTICLE
Xiaoxiao Hu, Caifen Wang, Lebing Wang, Zhaoxin Liu, Li Wu, Guoqing Zhang, Lin Yu, Xiaohong Ren, Peter York, Lixin Sun, Jiwen Zhang, Haiyan Li
It is essential to optimize a carrier of dry powder inhalation (DPI) for the aerodynamic deposition in vitro to achieve pulmonary delivery of drug molecules in vivo. In this study, neutralized nanoporous γ-cyclodextrin metal-organic framework (CD-MOF) crystals with cubic morphology and uniform inhalation size were developed and modified as a DPI carrier for budesonide (BUD). Cholesterol (CHO) and leucine (LEU)-poloxamer were used to modify the CD-MOF powder for the improvement of flowability and particle aerodynamic behaviour, for which the particle size distribution, Carr's index and in vitro pulmonary deposition were assessed...
April 11, 2019: International Journal of Pharmaceutics
https://read.qxmd.com/read/30429877/blood-exosomes-regulate-the-tissue-distribution-of-grapefruit-derived-nanovector-via-cd36-and-igfr1-pathways
#15
JOURNAL ARTICLE
Qi-Long Wang, XiaoYing Zhuang, Mukesh K Sriwastva, Jingyao Mu, Yun Teng, Zhongbin Deng, Lifeng Zhang, Kumaran Sundaram, Anil Kumar, Donald Miller, Jun Yan, Huang-Ge Zhang
Tumor-specific delivery of therapeutics is challenging. One of the major hurdles for successfully delivering targeted agents by nanovectors is the filtering role of the liver in rapidly sequestering nanovectors from the circulation. Exosomes, a type of endogenous nanoparticle, circulate continuously in the peripheral blood and play a role in intercellular communication. The aim of this study was to determine whether the level of endogenous exosomes has an effect on nanovector delivery efficiency of targeted agents...
2018: Theranostics
https://read.qxmd.com/read/29290827/local-intratracheal-delivery-of-perfluorocarbon-nanoparticles-to-lung-cancer-demonstrated-with-magnetic-resonance-multimodal-imaging
#16
JOURNAL ARTICLE
Lina Wu, Xiaofei Wen, Xiance Wang, Chunan Wang, Xilin Sun, Kai Wang, Huiying Zhang, Todd Williams, Allen J Stacy, Junjie Chen, Anne H Schmieder, Gregory M Lanza, Baozhong Shen
Eighty percent of lung cancers originate as subtle premalignant changes in the airway mucosal epithelial layer of bronchi and alveoli, which evolve and penetrate deeper into the parenchyma. Liquid-ventilation, with perfluorocarbons (PFC) was first demonstrated in rodents in 1966 then subsequently applied as lipid-encapsulated PFC emulsions to improve pulmonary function in neonatal infants suffering with respiratory distress syndrome in 1996. Subsequently, PFC nanoparticles (NP) were extensively studied as intravenous (IV) vascular-constrained nanotechnologies for diagnostic imaging and targeted drug delivery applications...
2018: Theranostics
https://read.qxmd.com/read/26913754/bioelectric-and-morphological-response-of-liquid-covered-human-airway-epithelial-calu-3-cell-monolayer-to-periodic-deposition-of-colloidal-3-mercaptopropionic-acid-coated-cdse-cds-zns-core-multishell-quantum-dots
#17
JOURNAL ARTICLE
Aizat Turdalieva, Johan Solandt, Nestan Shambetova, Hao Xu, Hans Blom, Hjalmar Brismar, Marina Zelenina, Ying Fu
Lung epithelial cells are extensively exposed to nanoparticles present in the modern urban environment. Nanoparticles, including colloidal quantum dots (QDs), are also considered to be potentially useful carriers for the delivery of drugs into the body. It is therefore important to understand the ways of distribution and the effects of the various types of nanoparticles in the lung epithelium. We use a model system of liquid-covered human airway epithelial Calu-3 cell cultures to study the immediate and long-term effects of repeated deposition of colloidal 3-mercaptopropionic-acid coated CdSe-CdS/ZnS core-multishell QDs on the lung epithelial cell surface...
2016: PloS One
https://read.qxmd.com/read/26680315/a-bimodal-molecular-imaging-probe-based-on-chitosan-encapsulated-magneto-fluorescent-nanocomposite-offers-biocompatibility-visualization-of-specific-cancer-cells-in-vitro-and-lung-tissues-in-vivo
#18
JOURNAL ARTICLE
Shanka Walia, Supriya Sharma, Pankaj Markand Kulurkar, Vikram Patial, Amitabha Acharya
Multifunctional hybrid nanocomposite material, consists of chitosan encapsulated iron oxide (as MRI contrasting agent), CdS (as fluorescent probe) nanoparticles and podophyllotoxin (as anticancer drug) was synthesized and characterized. The TEM studies suggested the size of the NPs to be in the range of 80-100 nm. These nanocomposites were treated with different cancer cell lines viz., KB, C6 and A549 cells. Fluorescence imaging and Perl's Prussian blue staining confirmed the presence of these nanocomposites inside both KB and C6 cells but not in A549 cells...
February 10, 2016: International Journal of Pharmaceutics
https://read.qxmd.com/read/25513951/comparison-of-ct-derived-ventilation-maps-with-deposition-patterns-of-inhaled-microspheres-in-rats
#19
JOURNAL ARTICLE
Richard E Jacob, Wayne J Lamm, Daniel R Einstein, Melissa A Krueger, Robb W Glenny, Richard A Corley
PURPOSE: Computer models for inhalation toxicology and drug-aerosol delivery studies rely on ventilation pattern inputs for predictions of particle deposition and vapor uptake. However, changes in lung mechanics due to disease can impact airflow dynamics and model results. It has been demonstrated that non-invasive, in vivo, 4DCT imaging (3D imaging at multiple time points in the breathing cycle) can be used to map heterogeneities in ventilation patterns under healthy and disease conditions...
April 2015: Experimental Lung Research
https://read.qxmd.com/read/24410445/gelation-chemistries-for-the-encapsulation-of-nanoparticles-in-composite-gel-microparticles-for-lung-imaging-and-drug-delivery
#20
JOURNAL ARTICLE
Nathalie M Pinkerton, Stacey W Zhang, Richard L Youngblood, Dayuan Gao, Shike Li, Bryan R Benson, John Anthony, Howard A Stone, Patrick J Sinko, Robert K Prud'homme
The formation of 10-40 μm composite gel microparticles (CGMPs) comprised of ∼100 nm drug containing nanoparticles (NPs) in a poly(ethylene glycol) (PEG) gel matrix is described. The CGMP particles enable targeting to the lung by filtration from the venous circulation. UV radical polymerization and Michael addition polymerization reactions are compared as approaches to form the PEG matrix. A fluorescent dye in the solid core of the NP was used to investigate the effect of reaction chemistry on the integrity of encapsulated species...
January 13, 2014: Biomacromolecules
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