Xiangting Ge, Tingting Xu, Meiyan Wang, Lijiao Gao, Yue Tang, Ningjie Zhang, Rui Zheng, Weimin Zeng, Gaozhi Chen, Bing Zhang, Yuanrong Dai, Yali Zhang
Asthma represents a significant global challenge that affects individuals across all age groups and imposes substantial social and economic burden. Due to heterogeneity of the disease, not all patients obtain benefit with current treatments. The objective of this study was to explore the impact of MD2 on the progression of asthma using L6H21, a novel MD2 inhibitor, to identify potential targets and drug candidates for asthma treatment. To establish an asthma-related murine model and evaluate the effects of L6H21, ovalbumin (OVA) was used to sensitize and challenge mice...
January 20, 2024: European Journal of Medical Research