Robert Alcock, Matthew G Cottingham, Christine S Rollier, Julie Furze, Samodh D De Costa, Marian Hanlon, Alexandra J Spencer, Jared D Honeycutt, David H Wyllie, Sarah C Gilbert, Migena Bregu, Adrian V S Hill
Live recombinant viral vectors based on adenoviruses and poxviruses are among the most promising platforms for development of new vaccines against diseases such as malaria, tuberculosis, and HIV-AIDS. Vaccines based on live viruses must remain infectious to be effective, so therefore need continuous refrigeration to maintain stability and viability, a requirement that can be costly and difficult, especially in developing countries. The sugars sucrose and trehalose are commonly used as stabilizing agents and cryoprotectants for biological products...
February 17, 2010: Science Translational Medicine