keyword
https://read.qxmd.com/read/38318251/water-content-transition-temperature-and-fragility-influence-protection-and-anhydrobiotic-capacity
#1
JOURNAL ARTICLE
John F Ramirez, U G V S S Kumara, Navamoney Arulsamy, Thomas C Boothby
UNLABELLED: Water is essential for metabolism and all life processes. Despite this, many organisms distributed across the kingdoms of life survive near-complete desiccation or anhydrobiosis. Increased intracellular viscosity, leading to the formation of a vitrified state is necessary, but not sufficient, for survival while dry. What properties of a vitrified system make it desiccation-tolerant or -sensitive are unknown. We have analyzed 18 different in vitro vitrified systems, composed of one of three protective disaccharides (trehalose, sucrose, or maltose) and glycerol, quantifying their enzyme-protective capacity and their material properties in a dry state...
2024: BBA Adv
https://read.qxmd.com/read/38231713/atomization-of-cocoa-honey-using-whey-protein-isolate-to-produce-a-dry-formulation-with-improved-shelf-life-for-industrial-application
#2
JOURNAL ARTICLE
Christiano Pedro Guirlanda, Izabela Dutra Alvim, Jacqueline Aparecida Takahashi
Cocoa honey, a by-product obtained during the processing of cocoa, is a juice rich in pectin, organic acids, minerals and phenolic compounds with antioxidant properties. Fresh cocoa honey is quickly fermented due to its high content of reducing sugars, such as fructose and glucose, which limits its shelf life. Currently, cocoa honey is only commercialized in frozen form, as logistical challenges prevent the wide distribution or export of this by-product for applications in the market of sweets, jellies, beverages, confectionery, and nutraceutical foods among others...
November 26, 2023: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38140123/microwave-assisted-freeze-drying-impact-of-microwave-radiation-on-the-quality-of-high-concentration-antibody-formulations
#3
JOURNAL ARTICLE
Nicole Härdter, Raimund Geidobler, Ingo Presser, Gerhard Winter
Microwave-assisted freeze-drying (MFD) offers significant time savings compared to conventional freeze-drying (CFD). While a few studies have investigated the stability of biopharmaceuticals with low protein concentrations after MFD and storage, the impact of MFD on high-concentration monoclonal antibody (mAb) formulations remains unclear. In this study, we systematically examined the effect of protein concentration in MFD and assessed protein stability following MFD, CFD, and subsequent storage using seven protein formulations with various stabilizers and concentrations...
December 15, 2023: Pharmaceutics
https://read.qxmd.com/read/38014150/water-content-transition-temperature-and-fragility-influence-protection-and-anhydrobiotic-capacity
#4
John F Ramirez, U G V S S Kumara, Navamoney Arulsamy, Thomas C Boothby
UNLABELLED: Water is essential for metabolism and all life processes. Despite this, many organisms distributed across the kingdoms of life survive near-complete desiccation or anhydrobiosis (Greek for "life without water"). Increased intracellular viscosity, leading to the formation of a vitrified state is necessary, but not sufficient, for survival while dry. What properties of a vitrified system make it desiccation-tolerant or -sensitive are unknown. We have analyzed 18 different in vitro vitrified systems, composed of one of three protective disaccharides (trehalose, sucrose, or maltose) and varying amounts of glycerol, quantifying their enzyme-protective capacity and their material properties in a dry state...
November 16, 2023: bioRxiv
https://read.qxmd.com/read/37959096/a-new-ready-to-eat-product-based-on-enzymatically-peeled-hernandina-clementine-segments-and-citrus-syrup
#5
JOURNAL ARTICLE
Huertas M Díaz-Mula, Juan P López, María Serrano, María T Pretel
Ready-to-eat fresh fruit have an increasing presence in international markets due to their convenience and health benefits. However, these products are highly perishable and efficient technologies to increase their shelf life are needed. In the present research, different citrus fruit species and cultivars from organic farming were assessed to obtain enzymatically peeled citrus segments. The best results in terms of segment quality were observed for 'Hernandina' clementine, which was chosen to make a new ready-to-eat product based on peeled citrus segments that were packaged in glass jars with a light syrup made of citrus juice and organic sugar cane...
October 30, 2023: Foods (Basel, Switzerland)
https://read.qxmd.com/read/37886415/improving-the-3d-printability-of-sugar-glass-to-engineer-sacrificial-vascular-templates
#6
JOURNAL ARTICLE
Brenden N Moeun, Stephanie A Fernandez, Simon Collin, Gabrielle Gauvin-Rossignol, Theophraste Lescot, Marc-André Fortin, Jean Ruel, André Bégin-Drolet, Richard L Leask, Corinne A Hoesli
A prominent obstacle in scaling up tissue engineering technologies for human applications is engineering an adequate supply of oxygen and nutrients throughout artificial tissues. Sugar glass has emerged as a promising 3D-printable, sacrificial material that can be used to embed perfusable networks within cell-laden matrices to improve mass transfer. To characterize and optimize a previously published sugar ink, we investigated the effects of sucrose, glucose, and dextran concentration on the glass transition temperature ( Tg ), printability, and stability of 3D-printed sugar glass constructs...
October 1, 2023: 3D Printing and Additive Manufacturing
https://read.qxmd.com/read/37837014/sensitive-and-compact-evanescent-waveguide-optical-detector-for-sugar-sensing-in-commercial-beverages
#7
JOURNAL ARTICLE
Alessio Buzzin, Rita Asquini, Domenico Caputo, Giampiero de Cesare
This work presents a compact and sensitive refractive index sensor able to evaluate the concentration of an analyte in a sample. Its working principle leverages on the changes in the optical absorption features introduced by the sample itself on the evanescent waves of a light beam. The device's high compactness is achieved by embedding the sample-light interaction site and the detector in a 1 cm2 glass substrate, thanks to microelectronics technologies. High sensitivity is obtained by employing a low-noise p-i-n hydrogenated amorphous silicon junction, whose manufacture process requires only four UV lithographic steps on a glass substrate, thus ensuring low production costs...
September 30, 2023: Sensors
https://read.qxmd.com/read/37447536/effect-of-monomers-of-3-hydroxyhexanoate-on-properties-of-copolymers-poly-3-hydroxybutyrate-co-3-hydroxyhexanoate
#8
JOURNAL ARTICLE
Tatiana G Volova, Mayya V Uspenskaya, Evgeniy G Kiselev, Aleksey G Sukovatyi, Natalia O Zhila, Aleksander D Vasiliev, Ekaterina I Shishatskaya
The properties of poly(3-hydroxybutyrate- co -3-hydroxyhexanoate) P(3HB- co -3HHx) copolymers with different ratios of monomers synthesized by the wild-type strain Cupriavidus necator B-10646 on sugars, and an industrial sample from Kaneka synthesized by the recombinant strain C. necator NSDG-ΔfadB1 on soybean oil, were studied in a comparative aspect and in relation to poly(3-hydroxybutyrate) P(3HB). The copolymer samples, regardless of the synthesis conditions or the ratio of monomers, had reduced values of crystallinity degree (50-60%) and weight average molecular weight (415-520 kDa), and increased values of polydispersity (2...
June 29, 2023: Polymers
https://read.qxmd.com/read/37331877/comparison-of-alternative-neutral-detergent-fiber-methods-to-the-aoac-definitive-method
#9
JOURNAL ARTICLE
Mary Beth Hall, David R Mertens
Neutral detergent fiber (NDF) is the most commonly reported metric for fiber in dairy cattle nutrition. An empirical method, NDF is defined by the procedure used to measure it. The current definitive method for NDF treated with amylase (aNDF) is AOAC Official Method 2002.04 performed on dried samples ground through the 1-mm screen of a cutting mill with refluxing and then filtration through Gooch crucibles without (AOAC-; reference method) or with (AOAC+) a glass fiber filter filtration aid. Other methods in use include grinding materials through the 1-mm screen of an abrasion mill, using filtration through a Buchner funnel with a glass fiber filter (Buch), and use of the ANKOM system (ANKOM Technology, Macedon, NY) that simultaneously extracts and filters samples through filter bags with larger (F57) or smaller (F58) particle size retentions...
June 16, 2023: Journal of Dairy Science
https://read.qxmd.com/read/36981193/effects-of-extraction-and-evaporation-methods-on-physico-chemical-functional-and-nutritional-properties-of-syrups-from-barhi-dates-phoenix-dactylifera-l
#10
JOURNAL ARTICLE
Kanokporn Julai, Pimnapanut Sridonpai, Chitraporn Ngampeerapong, Karaked Tongdonpo, Uthaiwan Suttisansanee, Wantanee Kriengsinyos, Nattira On-Nom, Nattapol Tangsuphoom
Date fruits ( Phoenix dactylifera L.) are rich in sugar and also contain a substantial amount of phenolic compounds. Therefore, date fruits can be used to produce an alternative sweetener, having lower glycemic index than sucrose. This study investigated the effects of extraction and evaporation methods on various properties of the syrups prepared from Barhi dates. Extraction of date juice with the aid of pectinase or cellulase significantly enhanced the production yield, total phenolic content, and antioxidant activities determined by Ferric Reducing Antioxidant Power and Oxygen Radical Absorbance Capacity assays...
March 16, 2023: Foods (Basel, Switzerland)
https://read.qxmd.com/read/36951575/structure-analysis-and-thermal-stability-of-phb-recovered-from-sugar-industry-waste
#11
JOURNAL ARTICLE
Rekha Kanzariya, Alok Gautam, Sachin Parikh, Maulin Shah, Shina Gautam
The current article emphasized on cultural conditions for Alcaligenes sp. NCIM 5085 to synthesize Polyhydroxybutyrate (PHB) from sugar industry waste during batch fermentation. Alcaligenes sp. NCIM 5085 was found to grow best in conditions that included 40 g l-1 of cane molasses, 1 g l-1 of ammonium sulphate, 10% inoculum with neutral pH and 48 h of incubation time. Sudan Black B staining was employed to verify the PHB synthesis initially, and further TEM analysis was performed to confirm it...
March 23, 2023: Biotechnology & Genetic Engineering Reviews
https://read.qxmd.com/read/36673403/different-treatments-for-sugarcane-juice-preservation
#12
JOURNAL ARTICLE
Pooja Dhansu, Bakshi Ram, Ashish Kumar Singh, Sudhir Kumar Tomar, Ramaiyan Karuppaiyan, Ravinder Kumar, Manohar Lal Chhabra, Ajay Singh, Arun Kumar Raja, Prashant Kaushik, Shashi Kant Pandey
This investigation aimed to optimize the time, pH, pressure, and temperature of sugarcane juice pasteurization and to develop a "ready to serve" bottled sugarcane juice with a high preservation efficiency. Fresh sugarcane juice was extracted from sugarcane genotype Co 89003, and beverage samples were collected using three different treatments: sulphitation of juice with the addition of potassium metabisulphite (KMS-25, 50, 100, and 150 ppm), acidification of juice (addition of citric acid, to reduce the pH of the juice to 4...
January 9, 2023: Foods (Basel, Switzerland)
https://read.qxmd.com/read/36537292/an-innovative-ethosuximide-granule-formulation-designed-for-pediatric-use-comparative-pharmacokinetics-safety-tolerability-and-palatability-profile-versus-reference-syrup
#13
RANDOMIZED CONTROLLED TRIAL
Léonore Diezi, Kim Dao, Vincent Jullien, Caroline Roussel-Maupetit, Ingrid Burton, Pascal André, Carine Bardinet, Laura E Rothuizen, Haithem Chtioui, Maria A Manso-Silvan, Catherine Guittet, Françoise Brunner-Ferber, Francois Vandenhende, Catherine Chiron, Luc-André Granier, Thierry Buclin
Ethosuximide, the first-line therapy for childhood absence epilepsy, is currently formulated as a syrup (Zarontin®, Pfizer) with a bitter taste and high sugar content, poorly adapted to children, and a ketogenic diet. The collaborative European FP7 project KIEKIDS aimed at developing an innovative sugar-free, tasteless formulation convenient for pediatric use. This dual Phase-I study evaluated two granule formulations based on lipid multiparticulate (LMP) technology. Two panels of 6 healthy adult volunteers underwent a randomized, placebo-controlled, partly blinded, 3-way cross-over trial, comparing ethosuximide granules A or B with placebo granules and syrup at single 10 mg/kg doses...
February 2023: Pharmacology Research & Perspectives
https://read.qxmd.com/read/36334126/evaluation-of-double-expression-system-for-co-expression-and-co-immobilization-of-flavonoid-glucosylation-cascade
#14
JOURNAL ARTICLE
Agata Matera, Kinga Dulak, Sandra Sordon, Kacper Waśniewski, Ewa Huszcza, Jarosław Popłoński
Glucosylation cascade consisting of Leloir glycosyltransferase and sucrose synthase with in situ regeneration system of expensive and low available nucleotide sugars is a game-changing strategy for enzyme-based production of glycoconjugates of relevant natural products. We designed a stepwise approach including co-expression and one-step purification and co-immobilization on glass-based EziG resins of sucrose synthase from Glycine max (GmSuSy) with promiscuous glucosyltransferase YjiC from Bacillus licheniformis to produce efficient, robust, and versatile biocatalyst suited for preparative scale flavonoid glucosylation...
November 5, 2022: Applied Microbiology and Biotechnology
https://read.qxmd.com/read/36210015/instagram-based-priming-to-nudge-drink-choices-subtlety-is-not-the-answer
#15
JOURNAL ARTICLE
Enola Kay, Eva Kemps, Ivanka Prichard, Marika Tiggemann
Instagram-based priming (e.g., subtly incorporating healthy drinks into the background of Instagram images) could potentially nudge healthier consumption behaviours. Given the negative health consequences associated with sugar-sweetened-beverage consumption, two experiments tested the effect of three sets of Instagram-based primes for nudging drink choices from a visual food and drinks display. Participants (18-25 years) were randomly assigned to view a series of Instagram advertising images (for technology, travel, or homeware products) that included a glass containing water (water prime) or cola (soft drink prime), or no drink (control)...
October 6, 2022: Appetite
https://read.qxmd.com/read/36173901/effect-of-lactose-and-milk-protein-on-thermal-resistance-of-enterococcus-faecium-nrrl-b-2354-and-salmonella-in-dairy-powders
#16
JOURNAL ARTICLE
Nurul H Ahmad, Bradley P Marks, Elliot Ryser
Microbial challenge studies using nonpathogenic surrogates provide a practical means for validating thermally based pathogen controls for low-moisture foods (LMFs). Because the relative thermal resistance, or kill ratio, of Enterococcus faecium NRRL B-2354 (a nonpathogenic surrogate) to Salmonella is greatly influenced by food composition, this study assessed relative thermal resistance of a five-strain Salmonella cocktail and E. faecium in skim milk powder (SMP), lactose-free skim milk powder (LSMP), 90% milk protein isolate (MPI), and lactose powder (LP)...
September 29, 2022: Journal of Food Protection
https://read.qxmd.com/read/36156387/glass-transitions-in-frozen-systems-as-influenced-by-molecular-weight-of-food-components
#17
JOURNAL ARTICLE
Jin-Hong Zhao, Pavitra Krishna Kumar, Shyam S Sablani
Freezing is a frequently used way to expand the storage life of foods with high water content. Under suitable cooling rates, frozen systems attain a condition of maximum freeze concentration, which is characterized by the glass transition temperature (Tg '), end point of freezing or onset of melting (Tm '), and concentration of solids (Xs ') in the maximum-freeze-concentrated matrix. The value of Tg ', Tm ', and Xs ' depends on the chemical composition of frozen system. Below Tg ', the rates of deteriorative reactions are significantly reduced...
September 26, 2022: Comprehensive Reviews in Food Science and Food Safety
https://read.qxmd.com/read/36136953/-technological-features-of-fermented-beverages-production-using-kombucha
#18
JOURNAL ARTICLE
V M Vorobyeva, I S Vorobyeva, V A Sarkisyan, Yu V Frolova, A A Kochetkova
Kombucha is a beverage made by fermenting sweetened brewed tea (substrate) by symbiotic culture of yeast and bacteria. Numerous researches on optimization of fermentation process, determination of the influence of technological factors on physical and chemical properties, formation of taste and flavor profile of the beverages, prevention of industrial product risks are due to the growing popularity of kombucha in Europe and the USA. Technological features of kombucha production are to optimize conditions for the growth of symbiotic culture and substrate fermentation...
2022: Voprosy Pitaniia
https://read.qxmd.com/read/35809832/frozen-storage-of-proteins-use-of-mannitol-to-generate-a-homogenous-freeze-concentrate
#19
JOURNAL ARTICLE
Jayesh Sonje, Carly Fleagle Chisholm, Raj Suryanarayanan
Therapeutic proteins may be subjected to several freeze-thaw cycles throughout manufacturing and storage. The protein solution composition and the freezing conditions may lead to incomplete ice crystallization in the frozen state. This can also result in freeze-concentrate heterogeneity characterized by multiple glass transition temperatures and protein destabilization. The overall objective was to investigate the potential advantages of including a crystallizing excipient (mannitol) along with a sugar (sucrose or trehalose) for frozen storage...
July 6, 2022: International Journal of Pharmaceutics
https://read.qxmd.com/read/35741877/systematic-investigation-on-the-glass-transition-temperature-of-binary-and-ternary-sugar-mixtures-and-the-applicability-of-gordon-taylor-and-couchman-karasz-equation
#20
JOURNAL ARTICLE
Martin Schugmann, Petra Foerst
Glass transition temperatures ( Tg ) of carbohydrate mixtures consisting of only one monomer and glycosidic binding type (aldohexose glucose, α1-4-glycosidic bonded) were studied by differential scanning calorimetry (DSC). The aim of this work was to systematically assess the predictability of Tg of anhydrous binary and ternary sugar mixtures focusing on the components Tg , molecular chain length, and shape. Binary systems were investigated with glucose as a monosaccharide and its linear di-, tri-, tetra-, penta-, hexa-, and heptasaccharides...
June 7, 2022: Foods (Basel, Switzerland)
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