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Pulmonary fluorescence imaging

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https://www.readbyqxmd.com/read/29241970/identification-of-a-folate-receptor-targeted-near-infrared-molecular-contrast-agent-to-localize-pulmonary-adenocarcinomas
#1
Jarrod D Predina, Andrew D Newton, Courtney Connolly, Ashley Dunbar, Michael Baldassari, Charuhas Deshpande, Edward Cantu, Jason Stadanlick, Sumith A Kularatne, Philip S Low, Sunil Singhal
Non-small cell lung cancer (NSCLC) is the number one cancer killer in the United States. Despite attempted curative surgical resection, nearly 40% of patients succumb to recurrent disease. High recurrence rates may be partially explained by data suggesting that 20% of NSCLC patients harbor synchronous disease that is missed during resection. In this report, we describe the use of a novel folate receptor-targeted near-infrared contrast agent (OTL38) to improve the intraoperative localization of NSCLC during pulmonary resection...
October 26, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29200901/the-bifunctional-effect-of-propofol-on-thromboxane-agonist-u46619-induced-vasoconstriction-in-isolated-human-pulmonary-artery
#2
Ning Hao, Wang Zhaojun, Sujuan Kuang, Guangyan Zhang, Chunyu Deng, Jue Ma, Jianxiu Cui
Propofol is known to cause vasorelaxation of several systemic vascular beds. However, its effect on the pulmonary vasculature remains controversial. In the present study, we investigated the effects of propofol on human pulmonary arteries obtained from patients who had undergone surgery. Arterial rings were mounted in a Multi-Myograph system for measurement of isometric forces. U46619 was used to induce sustained contraction of the intrapulmonary arteries, and propofol was then applied (in increments from 10-300 µM)...
November 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29049837/clinical-application-of-projection-mapping-technology-for-surgical-resection-of-lung-metastasis
#3
Toyofumi F Chen-Yoshikawa, Etsuro Hatano, Atsushi Yoshizawa, Hiroshi Date
Indocyanine green fluorescent image-guided surgery was developed to identify primary and metastatic nodules of various malignancies. However, currently, surgeons need to identify the fluorescent image on a monitor, which impedes surgical procedures. Herein, we developed a novel projection mapping device that can cast the real-time fluorescent image onto the surface of the targeted organ. We performed surgical resection of a lung metastasis of hepatoblastoma using this technique. The projection mapping technique clearly detected the pulmonary lesion, and no other lesions were identified in the ipsilateral thorax...
July 28, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29035996/radioguided-occult-lesion-localization-technical-procedures-and-clinical-applications
#4
Gianpiero Manca, Sara Mazzarri, Domenico Rubello, Elisa Tardelli, Roberto C Delgado-Bolton, Francesco Giammarile, Manuela Roncella, Duccio Volterrani, Patrick M Colletti
PURPOSE: Regarding radioguided surgery, the concept of "radioguided occult lesion localization" (ROLL) is based on both preoperative interventional imaging and intraoperative radioguided detection of a clinically occult neoplastic lesion. METHODS: This methodology consists in the direct administration into the lesion of Tc-macroaggregated human albumin formed by relatively large particles retained at the injection site, which direct radioguided excisional biopsy...
December 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28994575/thrombin-activatable-microbubbles-as-potential-ultrasound-contrast-agents-for-the-detection-of-acute-thrombosis
#5
Jacques Lux, Alexander M Vezeridis, Kenneth Hoyt, Stephen R Adams, Amanda M Armstrong, Shashank R Sirsi, Robert F Mattrey
Acute deep vein thrombosis (DVT) is the formation of a blood clot in the deep veins of the body that can lead to fatal pulmonary embolism. Acute DVT is difficult to distinguish from chronic DVT by ultrasound (US), the imaging modality of choice, and is therefore treated aggressively with anticoagulants, which can lead to internal bleeding. Here we demonstrate that conjugating perfluorobutane-filled (PFB-filled) microbubbles (MBs) with thrombin-sensitive activatable cell-penetrating peptides (ACPPs) could lead to the development of contrast agents that detect acute thrombosis with US imaging...
November 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28977356/prolonged-intravenous-indocyanine-green-visualization-by-temporary-pulmonary-vein-clamping-real-time-intraoperative-fluorescence-image-guide-for-thoracoscopic-anatomical-segmentectomy
#6
Atsushi Ito, Motoshi Takao, Akira Shimamoto, Hideto Shimpo
The real-time endoscopic colour and fluorescence-merged imaging system, using intravenous injection of indocyanine green (ICG), allows a clear surgical view, which facilitates identification of the pulmonary inter-segmental plane in thoracoscopic surgery. However, the staining time is too short to mark and cut the intersegmental plane, because the mean washout time of ICG is only a few minutes in the clinical setting. To overcome this limitation, we have developed a new technique for prolongation of ICG staining time...
December 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28957813/nicotine-induced-airway-smooth-muscle-cell-proliferation-involves-trpc6-dependent-calcium-influx-via-%C3%AE-7-nachr
#7
Wei Hong, Gongyong Peng, Binwei Hao, Baoling Liao, Zhuxiang Zhao, Yumin Zhou, Fang Peng, Xiuqin Ye, Lingmei Huang, Mengning Zheng, Jinding Pu, Chunxiao Liang, Erkang Yi, Huanhuan Peng, Bing Li, Pixin Ran
BACKGROUND/AIMS: The proliferation of human bronchial smooth muscle cells (HBSMCs) is a key pathophysiological component of airway remodeling in chronic obstructive pulmonary disease (COPD) for which pharmacotherapy is limited, and only slight improvements in survival have been achieved in recent decades. Cigarette smoke is a well-recognized risk factor for COPD; however, the pathogenesis of cigarette smoke-induced COPD remains incompletely understood. This study aimed to investigate the mechanisms by which nicotine affects HBSMC proliferation...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28950327/the-identification-of-sub-centimetre-nodules-by-near-infrared-fluorescence-thoracoscopic-systems-in-pulmonary-resection-surgeries
#8
Yamin Mao, Chongwei Chi, Fan Yang, Jian Zhou, Kunshan He, Hao Li, Xiuyuan Chen, Jinzuo Ye, Jun Wang, Jie Tian
OBJECTIVES: Current surgical procedures lack high-sensitivity intraoperative imaging guidance, leading to undetected micro tumours. In vivo near-infrared (NIR) fluorescence imaging provides a powerful tool for identifying small nodules. The aim of this study was to examine our experience of using 2 different NIR devices in pulmonary resection surgery. METHODS: From August 2015 to October 2016, 36 patients with lung nodules underwent NIR fluorescence imaging thoracoscopic surgery...
December 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28868028/primary-cystic-pleuropulmonary-synovial-sarcoma-presenting-as-recurrent-pneumothorax
#9
Eric D Johnson, Erinn Downs-Kelly, David A Bull, H Evin Gulbahce
Primary pleuropulmonary synovial sarcomas are quite rare, representing 0.1-0.5% of all pulmonary malignancies. We report an entirely cystic monophasic synovial sarcoma in a 25-year-old male who presented with recurrent pneumothorax and no evidence of a mass lesion on imaging. The purpose of this case report is to increase awareness of neoplasms clinically presenting as a pneumothorax with no imagining evidence of a mass-forming lesion and emphasize the significance of fluorescent in situ hybridization testing in nontypical synovial sarcoma cases...
May 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28861888/effect-of-qingfei-mixture-on-pediatric-mycoplasma-pneumoniae-pneumonia-with-phlegm-heat-obstructing-fei-lung-syndrome
#10
Ai-Jun Yang, Kun Xi, Yan-Qing Yao, Ying-Xue Ding, Li-Jun Yang, Hong Cui
OBJECTIVE: To explore the effect and mechanism of Qingfei Mixture (), a Chinese medicine, in treating mycoplasma pneumonia (MP) in MP patients and rat model METHODS: A total of 46 MP children with phlegm heat obstructing Fei (Lung) syndrome were randomly assigned to two groups by the method of random number table, with 23 children in each group. The control group was treated with intravenous infusion of azithromycin; the treatment group received intravenous infusion of azithromycin and oral administration of Qingfei Mixture...
September 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28837149/idh3-mediates-apoptosis-of-alveolar-epithelial-cells-type-2-due-to-mitochondrial-ca-2-uptake-during-hypocapnia
#11
Martina Kiefmann, Sascha Tank, Paula Keller, Christian Börnchen, Jan L Rinnenthal, Marc-Oliver Tritt, Leonie Schulte-Uentrop, Cynthia Olotu, Alwin E Goetz, Rainer Kiefmann
In adult respiratory distress syndrome (ARDS) pulmonary perfusion failure increases physiologic dead-space (VD/VT) correlating with mortality. High VD/VT results in alveolar hypocapnia, which has been demonstrated to cause edema formation, atelectasis, and surfactant depletion, evoked, at least in part, by apoptosis of alveolar epithelial cells (AEC). However, the mechanism underlying the hypocapnia-induced AEC apoptosis is unknown. Here, using fluorescent live-cell imaging of cultured AEC type 2 we could show that in terms of CO2 sensing the tricarboxylic acid cycle enzyme isocitrate dehydrogenase (IDH) 3 seems to be an important player because hypocapnia resulted independently from pH in an elevation of IDH3 activity and subsequently in an increase of NADH, the substrate of the respiratory chain...
August 24, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28798254/oxygen-dependent-changes-in-lung-development-do-not-affect-epithelial-infection-with-influenza-a-virus
#12
William Domm, Min Yee, Ravi S Misra, Robert Gelein, Aitor Nogales, Luis Martinez Sobrido, Michael A O'Reilly
Infants born prematurely often require supplemental oxygen that contributes to aberrant lung development and increased pulmonary morbidity following a respiratory viral infection. We have been using a mouse model to understand how early-life hyperoxia affects the adult lung response to influenza A virus (IAV) infection. Prior studies showed how neonatal hyperoxia (100% oxygen) increased sensitivity of adult mice to infection with influenza A virus (IAV (A/Hong Kong/X31) H3N2) as defined by persistent inflammation, pulmonary fibrosis, and mortality...
August 10, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28796342/elucidation-of-insulin-assembly-at-acidic-and-neutral-ph-characterization-of-low-molecular-weight-oligomers
#13
Matthew T Mawhinney, Thomas L Williams, James L Hart, Mitra L Taheri, Brigita Urbanc
Deficiency in insulin secretion and function that characterize type 2 diabetes often requires administration of extraneous insulin, leading to injection-site amyloidosis. Insulin aggregation at neutral pH is not well understood. Although oligomer formation is believed to play an important role, insulin oligomers have not been fully characterized yet. Here, we elucidate similarities and differences between in vitro insulin aggregation at acidic and neutral pH for a range of insulin concentrations (2.5-100 μM) by using kinetic thioflavin T fluorescence, circular dichroism, atomic force and electron microscopy imaging...
November 2017: Proteins
https://www.readbyqxmd.com/read/28746152/intraoperative-molecular-imaging-combined-with-positron-emission-tomography-improves-surgical-management-of-peripheral-malignant-pulmonary-nodules
#14
Jarrod D Predina, Andrew D Newton, Jane Keating, Eduardo M Barbosa, Olugbenga Okusanya, Leilei Xia, Ashley Dunbar, Courtney Connolly, Michael P Baldassari, Jack Mizelle, Edward J Delikatny, John C Kucharczuk, Charuhas Deshpande, Sumith A Kularatne, Phillip Low, Jeffrey Drebin, Sunil Singhal
OBJECTIVE: To determine if intraoperative molecular imaging (IMI) can improve detection of malignant pulmonary nodules. BACKGROUND: 18-Fluorodeoxyglucose positron emission tomography (PET) is commonly utilized in preoperative assessment of patients with solid malignancies; however, false negatives and false positives remain major limitations. Using patients with pulmonary nodules as a study model, we hypothesized that IMI with a folate receptor targeted near-infrared contrast agent (OTL38) can improve malignant pulmonary nodule identification when combined with PET...
September 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28641278/astragaloside-iv-alleviates-heat-induced-inflammation-by-inhibiting-endoplasmic-reticulum-stress-and-autophagy
#15
Zhiwei Dong, Jian Zhou, Ying Zhang, Yajie Chen, Zichen Yang, Guangtao Huang, Yu Chen, Zhiqiang Yuan, Yizhi Peng, Tongtong Cao
BACKGROUND: Thermal injury is the main cause of pulmonary disease in stroke after burn and can be life threatening. Heat-induced inflammation is an important factor that triggers a series of induces pathological changes. However, this mechanism underlying heat-induced inflammation in thermal inhalation injury remains unclear. Studies have revealed that astragaloside-IV (AS-IV), a natural compound extracted from Astragalus membranaceus, has protective effects in inflammatory diseases. Here, we investigated whether the protective effects of AS-IV occur because of the suppression of heat-induced endoplasmic reticulum (ER) stress and excessive autophagy Methods: AS-IV was administered to Wistar rats after thermal inhalation injury and 16HBE140-cells were treated with AS-IV...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28569457/advances-in-radioguided-surgery-in-oncology
#16
Renato A Valdés Olmos, Sergi Vidal-Sicart, Gianpiero Manca, Giuliano Mariani, Luisa F León-Ramírez, Domenico Rubello, Francesco Giammarile
The sentinel lymph node (SLN) biopsy is probably the most well known radioguided technique in surgical oncology. Today SLN biopsy reduces the morbidity associated with lymphadenectomy and increases the identification rate of occult lymphatic metastases by offering the pathologist the lymph nodes with the highest probability of containing metastatic cells. These advantages may result in a change in clinical clinical management both in melanoma and breast cancer patients. The SLN evaluation by pathology currently implies tumour burden stratification for further prognostic information...
June 1, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28536424/a-microfluidic-chamber-based-approach-to-map-the-shear-moduli-of-vascular-cells-and-other-soft-materials
#17
Béla Suki, Yingying Hu, Naohiko Murata, Jasmin Imsirovic, Jarred R Mondoñedo, Claudio L N de Oliveira, Niccole Schaible, Philip G Allen, Ramaswamy Krishnan, Erzsébet Bartolák-Suki
There is growing interest in quantifying vascular cell and tissue stiffness. Most measurement approaches, however, are incapable of assessing stiffness in the presence of physiological flows. We developed a microfluidic approach which allows measurement of shear modulus (G) during flow. The design included a chamber with glass windows allowing imaging with upright or inverted microscopes. Flow was controlled gravitationally to push culture media through the chamber. Fluorescent beads were conjugated to the sample surface and imaged before and during flow...
May 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28498283/synovial-sarcoma-of-peripheral-nerves-analysis-of-15-cases
#18
John S A Chrisinger, Usama I Salem, Lars-Gunnar Kindblom, Behrang Amini, Magnus Hansson, Jeanne M Meis
Synovial sarcoma of peripheral nerve (SSPN) is rare with only 26 cases reported in English. SSPN is often mistaken for a benign or malignant peripheral nerve sheath tumor (PNST) by clinicians and pathologists. Fifteen cases of SSPN were retrieved from the pathology files of 3 institutions. All tumors arose in a nerve based on imaging and/or operative findings and the diagnoses were histologically confirmed. Neuropathic symptoms predominated in 11 women and 4 men, 19- to 62-year-old (median, 39 years) with tumors involving the ulnar (5), median (3), peroneal (3) or sciatic (2) nerve, or the L4 or T1 nerve root (2)...
August 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28497233/standardization-and-optimization-of-intraoperative-molecular-imaging-for-identifying-primary-pulmonary-adenocarcinomas
#19
Jarrod D Predina, Olugbenga Okusanya, Andrew D Newton, Philip Low, Sunil Singhal
PURPOSE: Intraoperative molecular imaging (IMI) is an emerging technology used to locate pulmonary adenocarcinomas and identify positive margins during surgery. Background noise and tissue autofluorescence have been major obstacles. The goal of this study is to optimize the image quality of folate receptor alpha (FRα) targeted IMI for pulmonary adenocarcinomas by modifying emission data. PROCEDURES: A total of 15 lung cancer patients were enrolled in a pilot study...
May 11, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28495056/a-novel-minimally-invasive-near-infrared-thoracoscopic-localization-technique-of-small-pulmonary-nodules-a-phase-i-feasibility-trial
#20
Hideki Ujiie, Tatsuya Kato, Hsin-Pei Hu, Priya Patel, Hironobu Wada, Kosuke Fujino, Robert Weersink, Elsie Nguyen, Marcelo Cypel, Andrew Pierre, Marc de Perrot, Gail Darling, Thomas K Waddell, Shaf Keshavjee, Kazuhiro Yasufuku
OBJECTIVES: Localization and resection of nonvisible, nonpalpable pulmonary nodules during video-assisted thoracoscopic surgery are challenging. Our study was to determine the feasibility and safety of indocyanine green fluorescence localization and resection of small nodules using a near-infrared fluorescence thoracoscope. METHODS: Twenty patients with undiagnosed peripheral nodules smaller than 3 cm scheduled for computed tomography-guided microcoil placement followed by video-assisted thoracoscopic surgery wedge resection were enrolled...
August 2017: Journal of Thoracic and Cardiovascular Surgery
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