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Pulmonary drug delivery

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https://www.readbyqxmd.com/read/29792143/recent-updates-on-novel-approaches-in-insulin-drug-delivery-a-review-of-challenges-and-pharmaceutical-implications
#1
Manisha Pandey, Hira Choudhury, Cheah Xiao Yi, Chen Wei Mun, Goh Khang Ping, Guee Xin Rou, Bhalqish Jeet Kaur A/P Ambar Jeet Singh, Angel Ng Ann Jhee, Lee Kai Chin, Prashant Kesharwani, Bapi Gorain, Zahid Hussain
Diabetes mellitus, a metabolic disorder of glucose metabolism, is mainly associated with insulin resistance to the body cells, or impaired production of insulin by the pancreatic β-cells. Insulin is mainly required to regulate glucose metabolism in type 1 diabetes mellitus patients; however, many patients with type 2 diabetes mellitus also require insulin, especially when their condition cannot be controlled solely by oral hypoglycemic agents. Hence, major researches are ongoing attempting to improve the delivery of insulin in order to make it more convenient to patients who experience side effects from the conventional treatment procedure or non-adherence to insulin regimen due to multiple comorbid conditions...
May 22, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/29790581/the-pharmacokinetics-pharmacodynamics-and-tolerability-of-pur0200-a-novel-tiotropium-formulation-in-chronic-obstructive-pulmonary-disease
#2
Dave Singh, Arjun Ravi, Katie Kane, Tess Schmalbach, David L Hava
AIMS: PUR0200 is a tiotropium bromide formulation engineered with the iSPERSE dry powder delivery technology. PUR0200 is being developed as a bioequivalent alternative to tiotropium bromide delivered using Spiriva® HandiHaler® (HH). We investigated the bronchodilator effects, pharmacokinetics and safety of PUR0200 in COPD patients. METHODS: This was a randomised, placebo-controlled, crossover study with different PUR0200 doses and the comparator tiotropium HH...
May 23, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29788880/recent-advances-in-nanosuspension-technology-for-drug-delivery
#3
Daisy Arora, Bharat Khurana, Goutam Rath, Sanju Nanda, Amit K Goyal
BACKGROUND: Discovery and development of BCS class 1 drugs through high throughput screening is one of the biggest challenge faced by formulation scientist. METHODS: There are a number of approaches that have been exploited to enhance the solubility and permeability of drugs. Among them, development of nanosuspension has offered several benefits. These techniques may increase effective surface area due to nanonization of drug particles and further increases saturation solubility and dissolution properties for improved bioavailability...
May 21, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29778822/formulation-techniques-for-high-dose-dry-powders
#4
Ashlee D Brunaugh, Hugh D C Smyth
Delivery of drugs to the lungs via dry powder inhaler (DPI) is a promising approach for the treatment of both local pulmonary conditions and systemic diseases. Though DPIs are widely used for the pulmonary deposition of potent bronchodilators, anticholinergics, and corticosteroids, there is growing interest in the utilization of this delivery system for the administration of high drug doses to the lungs, as made evident by recent regulatory approvals for anti-microbial, anti-viral and osmotic agents. However, the formulation of high dose DPIs carries several challenges from both a physiological and physicochemical standpoint...
May 17, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29775476/maternal-asthma-is-associated-with-increased-risk-of-perinatal-mortality
#5
Mari Kemppainen, Anna-Maria Lahesmaa-Korpinen, Paula Kauppi, Martti Virtanen, Suvi M Virtanen, Riitta Karikoski, Mika Gissler, Turkka Kirjavainen
BACKGROUND: Asthma is the most common chronic disease during pregnancy and it may have influence on pregnancy outcome. OBJECTIVES: Our goal was to assess the association between maternal asthma and the perinatal risks as well as possible effects of asthma medication. METHODS: The study was based on a nationwide Finnish register-based cohort between the years 1996 and 2012 in the Drug and Pregnancy Database. The register data comprised 962 405 singleton live and stillbirths, 898 333 (93...
2018: PloS One
https://www.readbyqxmd.com/read/29773055/crystal-engineering-upcoming-paradigm-for-efficacious-pulmonary-drug-delivery
#6
Preshita P Desai, Sanyat S Mapara, Vandana B Patravale
BACKGROUND AND OBJECTIVE: Pulmonary drug delivery has transformed over a past few decades from being a platform for local pulmonary disease treatment to systemic drug delivery opportunities. In case of pulmonary delivery systems, particle properties are critical as they affect inhalation efficacy, pulmonary deposition, drug delivery and overall performance. With this in view, particle engineering has emerged as an advanced science that helps in designing of efficacious pulmonary delivery systems...
May 17, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29767993/multi-metallic-microparticles-increase-the-potency-of-rifampicin-against-intracellular-mycobacterium-tuberculosis
#7
Timothy Ellis, Michele Chiappi, Andres Garcia-Trenco, Maryam Al-Ejji, Srijata Sarkar, Theoni K Georgiou, Milo Sebastian Peter Shaffer, Teresa D Tetley, Stephan Schwander, Mary P Ryan, Alexandra E Porter
Mycobacterium tuberculosis (M.tb) has the extraordinary ability to adapt to the administration of antibiotics through the development of resistance mechanisms. By rapidly exporting drugs from within the cytosol, these pathogenic bacteria diminish antibiotic potency and drive the presentation of drug tolerant tuberculosis (TB). The membrane integrity of M.tb is pivotal in retaining these drug-resistant traits. Silver (Ag) and zinc oxide (ZnO) nanoparticles (NPs) are established antimicrobial agents that effectively compromise membrane stability, giving rise to increased bacterial permeability to antibiotics...
May 16, 2018: ACS Nano
https://www.readbyqxmd.com/read/29740700/the-best-of-two-worlds-pulmonary-vein-isolation-using-a-novel-radiofrequency-ablation-catheter-incorporating-contact-force-sensing-technology-and-56-hole-porous-tip-irrigation
#8
Tilman Maurer, Laura Rottner, Hisaki Makimoto, Bruno Reissmann, Christian-H Heeger, Christine Lemes, Thomas Fink, Johannes Riedl, Francesco Santoro, Peter Wohlmuth, Marius Volkmer, Shibu Mathew, Andreas Metzner, Feifan Ouyang, Karl-Heinz Kuck, Christian Sohns
AIMS: This study aimed to evaluate feasibility and safety as well as 1-year clinical outcome of pulmonary vein isolation (PVI) using a unique radiofrequency ablation catheter ("Thermocool SmartTouch SurroundFlow"; STSF) incorporating both, contact force (CF) sensing technology and enhanced tip irrigation with 56 holes, in one device. METHODS: A total of 110 patients suffering from drug-refractory atrial fibrillation underwent wide area circumferential PVI using either the STSF ablation catheter (75 consecutive patients, study group) or a CF catheter with conventional tip irrigation ("Thermocool SmartTouch", 35 consecutive patients, control group)...
May 8, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29738253/glycerol-solvates-dppc-headgroups-and-localises-in-the-interfacial-regions-of-model-pulmonary-interfaces-altering-bilayer-structure
#9
Wachirun Terakosolphan, Jemma L Trick, Paul G Royall, Sarah E Rogers, Olimpia Lamberti, Christian D Lorenz, Ben Forbes, Richard D Harvey
The inclusion of glycerol in formulations for pulmonary drug delivery may affect the bioavailability of inhaled steroids by retarding their transport across the lung epithelium. The aim of this study was to evaluate whether the molecular interactions of glycerol with model pulmonary interfaces provide a biophysical basis for glycerol modifying inhaled drug transport. Dipalmitoylphosphatidylcholine (DPPC) monolayers and liposomes were used as model pulmonary interfaces, in order to examine the effects of bulk glycerol (0 - 30% w/w) on their structures and dynamics using complementary biophysical measurements and molecular dynamics (MD) simulations...
May 8, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29731926/practical-approach-to-lung-health-experience-from-the-republic-of-macedonia
#10
Biljana Ilievska-Poposka, Maja Zakoska, Stefan Talevski
BACKGROUND: Among the adults and children aged 5 yrs who attend PHC settings, 20-30% seeks to care for respiratory symptoms. Over 80-90% of the respiratory patients suffer from acute respiratory infections (ARI), followed by chronic obstructive pulmonary diseases (COPD), asthma, and less frequently with pneumonia and tuberculosis (TB). To improve the quality of care in patients who seek assistance for respiratory symptoms in PHC settings and the efficiency of respiratory service delivery within healthcare systems, WHO has designated several initiatives among which one is PAL (Practical Approach to Lung Health)...
April 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29731372/-inhaled-chemotherapy-part-1-general-concept-and-current-technological-challenges
#11
REVIEW
R Rosière, J Hureaux, V Levet, K Amighi, N Wauthoz
Despite severe adverse effects, chemotherapy is still widely used in the treatment of lung tumors, including primary lung tumors and metastases. In order to reduce the risk of harm and to intensify treatment responses, several strategies have been described recently. These include the use of nanomedicine-based chemotherapies and pulmonary drug delivery. However, to treat lung tumors, inhalation cannot be effective and safe without an adaptation of current inhalation techniques, i.e. inhalation devices and drug formulations...
May 3, 2018: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/29715556/chitosan-alginate-nano-carrier-for-transdermal-delivery-of-pirfenidone-in-idiopathic-pulmonary-fibrosis
#12
Marzieh Abnoos, Mojdeh Mohseni, Seyed Ali Javad Mousavi, Khadijeh Ashtari, Roya Ilka, Bita Mehravi
Pirfenidone (PFD) is one of the pyridine family components with anti-inflammatory, antifibrotic effects and US FDA approved for the treatment of idiopathic pulmonary fibrosis (IPF). Presently, PFD is administered orally and this has setbacks. Hence, it is important to eliminate the pharmacotherapeutic limitations of PFD. This research was carried out to study the possibility of transdermal delivery of PFD using chitosan-sodium alginate nanogel carriers. In order to synthesize chitosan-sodium alginate nanoparticles loaded with PFD, the pre-gelation method was used...
April 28, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29697597/epicardial-biatrial-ablation-with-integrated-uni-bipolar-radiofrequency-technology-in-stand-alone-persistent-atrial-fibrillation
#13
Fabrizio Rosati, Claudio Muneretto, Elisa Merati, Gianluca Polvani, Massimo Moltrasio, Claudio Tondo, Antonio Curnis, Manuel Cerini, Alexandre Metras, Gianluigi Bisleri
OBJECTIVE: Although minimally invasive approaches for surgical treatment of stand-alone atrial fibrillation have gained popularity for the past decade, ablation technology and extensive lesion sets play a major role in the achievement of a successful procedure, especially in presence of persistent and long-standing persistent atrial fibrillation. We evaluated clinical outcomes after totally endoscopic biatrial epicardial ablation of persistent atrial fibrillation with a novel integrated uni-bipolar radiofrequency device...
March 2018: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/29693671/self-assembled-polymeric-micelles-for-combined-delivery-of-anti-inflammatory-gene-and-drug-to-the-lungs-by-inhalation
#14
Gyeungyun Kim, Chunxian Piao, Jungju Oh, Minhyung Lee
Acute lung injury (ALI) is a lung inflammatory disease for which pulmonary delivery of drug and gene could be a useful strategy. In this study, cholesterol-conjugated polyamidoamine (PAM-Chol) was synthesized and characterized as a carrier for combined delivery of anti-inflammatory gene and drug into the lungs by inhalation. The PAM-Chol formed self-assembled micelles in an aqueous solution with a critical micelle concentration of 0.22 mg ml-1. An in vitro transfection assay to L2 lung epithelial cells showed that the PAM-Chol micelle had higher transfection efficiency than lipofectamine and polyethylenimine (25 kDa, PEI25k)...
April 25, 2018: Nanoscale
https://www.readbyqxmd.com/read/29691812/excipient-selection-and-aerodynamic-characterization-of-nebulized-lipid-based-nanoemulsion-loaded-with-docetaxel-for-lung-cancer-treatment
#15
Azren Aida Asmawi, Norazlinaliza Salim, Cheng Loong Ngan, Haslina Ahmad, Emilia Abdulmalek, Mas Jaffri Masarudin, Mohd Basyaruddin Abdul Rahman
Docetaxel has demonstrated extraordinary anticancer effects on lung cancer. However, lack of optimal bioavailability due to poor solubility and high toxicity at its therapeutic dose has hampered the clinical use of this anticancer drug. Development of nanoemulsion formulation along with biocompatible excipients aimed for pulmonary delivery is a potential strategy to deliver this poorly aqueous soluble drug with improved bioavailability and biocompatibility. In this work, screening and selection of pharmaceutically acceptable excipients at their minimal optimal concentration have been conducted...
April 24, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29691755/my-patient-has-received-fluid-how-to-assess-its-efficacy-and-side-effects
#16
REVIEW
Xavier Monnet, Jean-Louis Teboul
Many efforts have been made to predict, before giving fluid, whether it will increase cardiac output. Nevertheless, after fluid administration, it is also essential to assess the therapeutic efficacy and to look for possible adverse effects. Like for any drug, this step should not be missed. Basically, volume expansion is aimed at improving tissue oxygenation and organ function. To assess this final result, clinical signs are often unhelpful. The increase in urine output in case of acute kidney injury is a poor marker of the kidney perfusion improvement...
April 24, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29688042/cyclosporine-a-porous-quaternized-chitosan-microspheres-as-a-novel-pulmonary-drug-delivery-system
#17
Ting-Ting Yang, Bao-Fang Wen, Kang Liu, Meng Qin, Yuan-Yuan Gao, De-Jun Ding, Wen-Tong Li, Yun-Xiang Zhang, Wei-Fen Zhang
N-[(2-Hydroxyl)-propyl-3-trimethyl ammonium] chitosan chloride (HTCC), a hydrosoluble chitosan derivative, has been extensively investigated as a class of drug delivery vehicles because of its unique features. However the studies on HTCC for pulmonary delivery systems have been rarely conducted. This study aimed to design porous microspheres (MS) containing cyclosporine A (CsA) using HTCC as the carrier. The physicochemical properties and biocompatibility of the MS were evaluated. The in vivo efficacy of MS was evaluated in an asthmatic rat model after pulmonary administration...
April 24, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29672222/macrophage-derived-extracellular-vesicles-mediates-smooth-muscle-hyperplasia-role-of-altered-mirna-cargo-in-response-to-hiv-infection-and-substance-abuse
#18
Himanshu Sharma, Mahendran Chinnappan, Stuti Agarwal, Pranjali Dalvi, Sumedha Gunewardena, Amy O'Brien-Ladner, Navneet K Dhillon
Our previous studies consistently demonstrate enhanced pulmonary vascular remodeling in HIV-infected intravenous drug users, and in simian immunodeficiency virus-infected macaques or HIV-transgenic rats exposed to opioids or cocaine. Although we reported an associated increase in perivascular inflammation, the exact role of inflammatory cells in the development of pulmonary vascular remodeling remains unknown. In this study, HIV-infected and cocaine (H+C)-treated human monocyte derived macrophages released a higher number of extracellular vesicles (EVs), compared to HIV-infected or uninfected cocaine-treated macrophages, with a significant increase in the particle size range to 100-150 nm...
April 19, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29653129/delivering-drugs-to-the-lungs-the-history-of-repurposing-in-the-treatment-of-respiratory-diseases
#19
Stephen P Newman
The repurposing of drug delivery by the pulmonary route has been applied to treatment and prophylaxis of an increasingly wide range of respiratory diseases. Repurposing has been most successful for the delivery of inhaled bronchodilators and corticosteroids in patients with asthma and chronic obstructive pulmonary disease (COPD). Repurposing utilizes the advantages that the pulmonary route offers in terms of more targeted delivery to the site of action, the use of smaller doses, and a lower incidence of side-effects...
April 11, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29602314/use-of-cilomilast-loaded-phosphatiosomes-to-suppress-neutrophilic-inflammation-for-attenuating-acute-lung-injury-the-effect-of-nanovesicular-surface-charge
#20
Fu-Chao Liu, Huang-Ping Yu, Cheng-Yu Lin, Ahmed O Elzoghby, Tsong-Long Hwang, Jia-You Fang
BACKGROUND: Cilomilast is a phosphodiesterase 4 (PDE4) inhibitor for treating inflammatory lung diseases. This agent has a narrow therapeutic index with significant adverse effects on the nervous system. This study was conducted to entrap cilomilast into PEGylated phosphatidylcholine-rich niosomes (phosphatiosomes) to improve pulmonary delivery via the strong affinity to pulmonary surfactant film. Neutrophils were used as a cell model to test the anti-inflammatory activity of phosphatiosomes...
March 30, 2018: Journal of Nanobiotechnology
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