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https://www.readbyqxmd.com/read/29326082/pharmaceutical-nanocrystals-production-by-wet-milling-and-applications
#1
REVIEW
Maria Malamatari, Kevin M G Taylor, Stavros Malamataris, Dennis Douroumis, Kyriakos Kachrimanis
Nanocrystals are regarded as an important nanoformulation approach exhibiting advantages of increased dissolution and saturation solubility with chemical stability and low toxicity. Nanocrystals are produced in the form of nanosuspensions using top-down (e.g., wet milling or high pressure homogenization) and bottom-up methods (e.g., antisolvent precipitation). Wet milling is a scalable method applicable to drugs with different physicochemical and mechanical properties. Nanocrystalline-based formulations, either as liquid nanosuspensions or after downstream processing to solid dosage forms, have been developed as drug delivery systems for various routes of administration (i...
January 8, 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29311495/fluorescent-imaging-analysis-for-distribution-of-fluorescent-dye-labeled-or-encapsulated-liposome-in-monocrotaline-induced-pulmonary-hypertension-model-rat
#2
Yo Muraki, Midori Yamasaki, Hirohisa Takeuchi, Kimio Tohyama, Noriyasu Sano, Takanori Matsuo
Pulmonary hypertension (PH) is a life-threatening lung disease. Despite the availability of several approved drugs, the development of a new treatment method is needed because of poor prognosis. Tissue selective drug delivery systems can avoid the adverse effects of current therapy and enhance efficacy. We evaluated the possibility of delivering drugs to the lungs of a PH rat model using fluorescence dye-labeled nanosized liposomes. To evaluate the tissue distribution following systemic exposure, fluorescent dye-labeled, 40-180 nm liposomes with and without polyethylene glycol (PEG) were intravenously administered to a monocrotaline-induced PH (MCT) rat model and tissue fluorescence was measured...
January 6, 2018: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29311480/tissue-clearing-techniques-enable-three-dimensional-visualization-of-aerosolized-model-compound-and-lung-structure-at-the-alveolar-scale
#3
Kohei Togami, Anri Kitayama, Takayuki Daisho, Rui Wang, Hitoshi Tada, Sumio Chono
In this study, we examined the usefulness of a tissue-clearing technique for the evaluation of the lung distribution of aerosolized drugs. An aerosol formulation of TexasRed dextran (70 kDa), a model compound of drug carrier for aerosolized drugs, was administered intrapulmonarily to mice using a MicroSprayer, and then DyLight 488-conjugated tomato lectin was administered intravenously to visualize general lung structure via the fluorescent labeling of alveolar and bronchial epithelial cells. Tissue clearing followed by laser scanning confocal microscopy enabled the three-dimensional visualization of intrapulmonary TexasRed dextran and the evaluation of its distribution at the alveolar scale without the preparation of thin tissue sections...
2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29290827/local-intratracheal-delivery-of-perfluorocarbon-nanoparticles-to-lung-cancer-demonstrated-with-magnetic-resonance-multimodal-imaging
#4
Lina Wu, Xiaofei Wen, Xiance Wang, Chunan Wang, Xilin Sun, Kai Wang, Huiying Zhang, Todd Williams, Allen J Stacy, Junjie Chen, Anne H Schmieder, Gregory M Lanza, Baozhong Shen
Eighty percent of lung cancers originate as subtle premalignant changes in the airway mucosal epithelial layer of bronchi and alveoli, which evolve and penetrate deeper into the parenchyma. Liquid-ventilation, with perfluorocarbons (PFC) was first demonstrated in rodents in 1966 then subsequently applied as lipid-encapsulated PFC emulsions to improve pulmonary function in neonatal infants suffering with respiratory distress syndrome in 1996. Subsequently, PFC nanoparticles (NP) were extensively studied as intravenous (IV) vascular-constrained nanotechnologies for diagnostic imaging and targeted drug delivery applications...
2018: Theranostics
https://www.readbyqxmd.com/read/29290812/circulating-magnetic-microbubbles-for-localized-real-time-control-of-drug-delivery-by-ultrasonography-guided-magnetic-targeting-and-ultrasound
#5
Beata Chertok, Robert Langer
Image-guided and target-selective modulation of drug delivery by external physical triggers at the site of pathology has the potential to enable tailored control of drug targeting. Magnetic microbubbles that are responsive to magnetic and acoustic modulation and visible to ultrasonography have been proposed as a means to realize this drug targeting strategy. To comply with this strategy in vivo, magnetic microbubbles must circulate systemically and evade deposition in pulmonary capillaries, while also preserving magnetic and acoustic activities in circulation over time...
2018: Theranostics
https://www.readbyqxmd.com/read/29250438/faraday-waves-based-integrated-ultrasonic-micro-droplet-generator-and-applications
#6
Chen S Tsai, Rong W Mao, Shirley C Tsai, Kaveh Shahverdi, Yun Zhu, Shih K Lin, Yu-Hsiang Hsu, Gerry Boss, Matt Brenner, Sari Mahon, Gerald C Smaldone
An in-depth review on a new ultrasonic micro-droplet generator which utilizes megahertz (MHz) Faraday waves excited by silicon-based multiple Fourier horn ultrasonic nozzles (MFHUNs) and its potential applications is presented. The new droplet generator has demonstrated capability for producing micro droplets of controllable size and size distribution and desirable throughput at very low electrical drive power. For comparison, the serious deficiencies of current commercial droplet generators (nebulizers) and the other ultrasonic droplet generators explored in recent years are first discussed...
2017: Micromachines
https://www.readbyqxmd.com/read/29243970/reactive-oxygen-species-damage-drives-cardiac-and-mitochondrial-dysfunction-following-acute-nano-titanium-dioxide-inhalation-exposure
#7
Cody E Nichols, Danielle L Shepherd, Quincy A Hathaway, Andrya J Durr, Dharendra Thapa, Alaeddin Abukabda, Jinghai Yi, Timothy R Nurkiewicz, John M Hollander
Nanotechnology offers innovation in products from cosmetics to drug delivery, leading to increased engineered nanomaterial (ENM) exposure. Unfortunately, health impacts of ENM are not fully realized. Titanium dioxide (TiO2) is among the most widely produced ENM due to its use in numerous applications. Extrapulmonary effects following pulmonary exposure have been identified and may involve reactive oxygen species (ROS). The goal of this study was to determine the extent of ROS involvement on cardiac function and the mitochondrion following nano-TiO2 exposure...
December 15, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/29235345/mucus-and-cell-penetrating-nanoparticles-embedded-in-nano-into-micro-formulations-for-pulmonary-delivery-of-ivacaftor-in-cystic-fibrosis
#8
Barbara Porsio, Emanuela Fabiola Craparo, Nicolò Mauro, Gaetano Giammona, Gennara Cavallaro
Here, mucus-penetrating nanoparticles for pulmonary administration of Ivacaftor in patients with cystic fibrosis (CF) were produced with the dual aim to enhance Ivacaftor delivery to the airway epithelial cells, by a rapid diffusion through the mucus barrier and, at the same time, promote Ivacaftor lung cellular uptake. Pegylated and Tat-decorated Fluorescent Nanoparticles (FNPs) were produced by nanoprecipitation, starting by two synthetic copolymers and showed nanometric sizes (~70 nm), slightly negative ζ potential and high cytocompatibility towards human bronchial epithelium cells...
December 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29231801/correction-journal-of-aerosol-medicine-and-pulmonary-drug-delivery-2017-30-1-53-63-doi-10-1089-jamp-2015-1282
#9
(no author information available yet)
No abstract text is available yet for this article.
December 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/29219321/sheta2-dry-powder-aerosols-for-tuberculosis-formulation-design-and-optimization-using-quality-by-design
#10
Mariam Ibrahim, Manolya Kukut Hatipoglu, Lucila Garcia-Contreras
Tuberculosis (TB) is a life threatening pulmonary infection caused by Mycobacterium tuberculosis (MTB). Current treatments are complex, lengthy and associated with severe side effects that decrease patient compliance and increase the probability of the emergence of drug resistant strains. Thus, more effective drugs with little to no side effects are needed to diversify the armamentarium against the global TB epidemic. SHetA2, an anticancer compound with null toxicity at doses much higher than the effective dose, was recently discovered to be active against MTB...
December 8, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29219058/macrophage-targeted-cellular-carriers-for-effective-delivery-of-anti-tubercular-drugs
#11
S Beg, Jaya Agnihotri, Shibhna Singh, Mohammad Wais
Newly developed vaccine VPM1002 confers paradigm swing in the prophylactic treatment of tuberculosis (TB).Multi drug resistant and latent TB in adults as well as in underprivileged patients is instigating menace over world population if the host is immune-compromised. One third of the world's population is infected with TB. Recently it is estimated around 9.6 million people around the world became sick with TB disease. There were 1.5 million TB-related deaths worldwide. Therefore with the advent in biotechnology and Nano engineering, newly adapted survival molecular mechanism of Mycobacterium tuberculosis, new targets receptors on alveolar macrophages must be explored out for eradication of TB from the globe...
December 7, 2017: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/29216806/an-industry-update-the-latest-developments-in-therapeutic-delivery
#12
Iain Simpson
This industry update covers the period from 1 September through 30 September 2017, and is based on information sourced from company press releases, scientific literature, patents and various news websites. The month saw the US FDA approve three new molecular entities, Aliqopa (copanlisib dihydrochloride) (Bayer Healthcare); Solosec (secnidazole) (Symbiomix Therapeutics) and Verzenio (abemaciclib) (Eli Lilly and Co). Intarcia Therapeutics Inc. has its application for approval of a novel drug device combination of exenatide for the treatment of diabetes rejected by FDA but said that it will work to address the concerns and refile the application...
January 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/29210318/inhalation-device-options-for-the-management-of-chronic-obstructive-pulmonary-disease
#13
Michael DePietro, Ileen Gilbert, Lauren A Millette, Michael Riebe
Chronic obstructive pulmonary disease (COPD) is characterized by chronic respiratory symptoms and airflow limitation, resulting from abnormalities in the airway and/or damage to the alveoli. Primary care physicians manage the healthcare of a large proportion of patients with COPD. In addition to determining the most appropriate medication regimen, which usually includes inhaled bronchodilators with or without inhaled corticosteroids, physicians are charged with optimizing inhalation device selection to facilitate effective drug delivery and patient adherence...
December 5, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/29197631/pulmonary-drug-delivery-to-older-people
#14
Martin Wallin, Tatsuaki Tagami, Lan Chen, Mingshi Yang, Hak-Kim Chan
Pulmonary diseases, such as asthma and chronic obstructive pulmonary disease (COPD), are common in older people. Treatment principles are well established in this group of patients; however, inadequate training and improper inhaler techniques often results in poor treatment outcomes. Healthcare professionals often do not have the required knowledge about the most common inhaler devices. Age-related conditions like cognitive ability and physical strength would also impact on the inhaler usage. Pharmacokinetics and pharmacodynamics may be affected by physiological changes, like impaired renal and hepatic functions and reduced lung functions...
November 29, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29189185/enhanced-both-in-vitro-and-in-vivo-kinetics-by-slns-induced-transdermal-system-of-furosemide-a-novel-approach
#15
Revathi Mannam, Indira Muzib Yallamalli
AIM AND BACKGROUND: Furosemide is a potent diuretic agent used to treat pulmonary arterial hypertension. Variable dosage regimen and poor pharmacokinetic parameters has led to the development of transdermal drug delivery system. A patent on suitability of multi-lamellar structures for excellent transdermal delivery (US 0367475A1) has encouraged us to formulate the solid lipid nanoparticles (SLNs) induced transdermal systems of furosemide to enhance the kinetic properties without incorporating any penetration enhancer and rate limiting polymers...
November 28, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29184405/absence-of-lung-fibrosis-after-a-single-pulmonary-delivery-of-lipid-nanocapsules-in-rats
#16
José Hureaux, Franck Lacoeuille, Frédéric Lagarce, Marie-Christine Rousselet, Aurélien Contini, Patrick Saulnier, Jean-Pierre Benoit, Thierry Urban
Lipid nanocapsules (LNCs) are potential drug carriers for pulmonary delivery since they can be nebulized without any structural or functional changes, and the aerosols produced are highly compatible with pulmonary drug delivery in human beings. The alveolar surface tension, in vitro cytotoxicity, biodistribution and pulmonary toxicity in rats of a single endotracheal spray of LNCs or paclitaxel-loaded LNCs were studied. In vitro cytotoxicity of LNCs after a spray remained unchanged. Biodistribution study showed a homogeneous repartition in the lungs in rats with an improvement in lung retention of the radiolabeled tracer loaded in LNCs compared to the absence of LNCs with a lung half-time of 8...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29180863/paclitaxel-and-quercetin-nanoparticles-co-loaded-in-microspheres-to-prolong-retention-time-for-pulmonary-drug-delivery
#17
Kang Liu, Weijuan Chen, Tingting Yang, Baofang Wen, Dejun Ding, Michael Keidar, Jinbao Tang, Weifen Zhang
High drug resistance, poor water solubility, short half-life, and low local drug concentration are obstacles for successful delivery of chemotherapeutic drugs for lung cancer. A new method involving the use of nanoparticles (NPs) for pulmonary delivery is proposed. However, use of NPs is limited by the particle size range for pulmonary drug delivery considering that NPs cannot be deposited directly into the lungs. NPs polymerized into microspheres (polymeric microspheres, PMs) will result in suitable particle sizes and retain the advantages of nanodrugs after redispersion when applied in pulmonary delivery...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29180257/insights-on-animal-models-to-investigate-inhalation-therapy-relevance-for-biotherapeutics
#18
REVIEW
A Guillon, T Sécher, L A Dailey, L Vecellio, M De Monte, M Si-Tahar, P Diot, C P Page, N Heuzé-Vourc'h
Acute and chronic respiratory diseases account for major causes of illness and deaths worldwide. Recent developments of biotherapeutics opened a new era in the treatment and management of patients with respiratory diseases. When considering the delivery of therapeutics, the inhaled route offers great promises with a direct, non-invasive access to the diseased organ and has already proven efficient for several molecules. To assist in the future development of inhaled biotherapeutics, experimental models are crucial to assess lung deposition, pharmacokinetics, pharmacodynamics and safety...
November 24, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29173154/effective-delivery-routes-and-strategies-for-solid-lipid-nanoparticles-sln-and-nanostructured-lipid-carriers-nlc
#19
Divyesh H Shastri
BACKGROUND: SLNs and NLCs have remarkably wide range of properties which make them useful for several potential applications in drug delivery, clinical medicine, and research, as well as in parenteral, dermal, pulmonary and topical delivery of drugs. The unique size-dependent properties of the solid lipid nanoparticles make them at the forefront of the rapidly developing field of nanotechnology offering development of new therapeutics having reduced toxic side effects and increased treatment efficacy...
November 21, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29158280/anti-pseudomonal-activity-of-phage-pev20-in-a-dry-powder-formulation-a-proof-of-principle-study-in-a-murine-lung-infection-model
#20
Rachel Yoon Kyung Chang, Ke Chen, Jiping Wang, Martin Wallin, Warwick Britton, Sandra Morales, Elizabeth Kutter, Jian Li, Hak-Kim Chan
Bacteriophage therapy is a promising alternative treatment to antibiotics as it has been documented to be efficacious against multi-drug resistant bacteria with minimal side effects. Several groups have demonstrated the efficacy of phage suspension in vivo to treat lung infections using intranasal delivery; however, phage dry powder administration to the lungs has not yet been explored. Powder formulations provide potential advantages over liquid formulation, including easy storage, transport and administration...
November 20, 2017: Antimicrobial Agents and Chemotherapy
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