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Vaccine delivery

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https://www.readbyqxmd.com/read/29351325/impact-of-educational-interventions-on-adolescent-attitudes-and-knowledge-regarding-vaccination-a-pilot-study
#1
Kate Carolan, Joanna Verran, Matthew Crossley, James Redfern, Nicola Whitton, Martyn Amos
BACKGROUND: Current immunisation levels in England currently fall slightly below the threshold recommended by the World Health Organization, and the three-year trend for vaccination uptake is downwards. Attitudes towards vaccination can affect future decisions on whether or not to vaccinate, and this can have significant public health implications. Interventions can impact future vaccination decisions, and these interventions can take several forms. Relatively little work has been reported on the use of vaccination interventions in young people, who form the next generation of individuals likely to make vaccination decisions...
2018: PloS One
https://www.readbyqxmd.com/read/29351277/ex-ante-assessment-of-different-vaccination-based-control-schedules-against-the-peste-des-petits-ruminants-virus-in-sub-saharan-africa
#2
Pachka Hammami, Renaud Lancelot, Joseph Domenech, Matthieu Lesnoff
BACKGROUND: Peste des petits ruminants (PPR) is a highly contagious and widespread viral infection of small ruminants (goats and sheep), causing heavy economic losses in many developing countries. Therefore, its progressive control and global eradication by 2030 was defined as a priority by international organizations addressing animal health. The control phase of the global strategy is based on mass vaccination of small ruminant populations in endemic regions or countries. It is estimated that a 70% post-vaccination immunity rate (PVIR) is needed in a given epidemiological unit to prevent PPR virus spread...
2018: PloS One
https://www.readbyqxmd.com/read/29343824/human-papillomavirus-prophylactic-vaccination-improves-reproductive-outcome-in-infertile-patients-with-hpv-semen-infection-a-retrospective-study
#3
Andrea Garolla, Luca De Toni, Alberto Bottacin, Umberto Valente, Maurizio De Rocco Ponce, Andrea Di Nisio, Carlo Foresta
In this study we aimed to evaluate the effect on reproductive outcome of HPV vaccination in male subjects of infertile couples with HPV semen infection. In this single-center study, we retrospectively enrolled 151 infertile couples with detection of HPV in semen, attending our Hospital Unit of Andrology between January 2013 and June 2015, counseled to receive adjuvant HPV vaccination. Seventy-nine accepted vaccination (vaccine group) whilst 72 did not (control group). Our protocol of follow-up, aimed to evaluate HPV viral clearance, consisted in semen analysis, INNO-LiPA and FISH for HPV in semen cells after 6 and 12 months from basal evaluation...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29336241/generation-of-the-fluorescent-hpv16-e7-protein-for-detection-of-delivery-in-vitro
#4
Sepideh Shahbazi, Azam Bolhassani, Arash Arashkia, Esmaeil Sadroddiny
Immunotherapies targeting the human papillomavirus (HPV) oncogenic proteins, E6 and E7, are effective to treat HPV-associated cervical malignancies. In this study, two types of the fusion E7-GFP proteins (i.e., with or without linker) were expressed in different E. coli strains. Then, the efficiency of GFP and E7-GFP transfection was compared with FITC-antibody protein control using TurboFect reagent in the HEK-293T cell line. Our data indicated that both E7-GFP fusion proteins were efficiently produced in M15 E...
January 15, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29334920/factors-influencing-access-of-pregnant-women-and-their-infants-to-their-local-healthcare-system-a-prospective-multi-centre-observational-study
#5
Shabir A Madhi, Luis M Rivera, Xavier Sáez-Llorens, Clara Menéndez, Nazira Carrim-Ganey, Mark F Cotton, Darren Katzman, Mariëtha M Luttig, Rosalba Candelario, Sherryl Baker, Mahua Roychoudhury
BACKGROUND: The successful implementation of maternal vaccination relies on results of clinical trials, considering the prenatal and postnatal attendance at selected healthcare institutions. This study evaluated factors influencing maternal/infant access to healthcare facilities to identify potential barriers to participation in future clinical trials on maternal vaccination. METHODS: In this prospective, multi-centre, observational study, pregnant women (N = 3243) were enrolled at ten sites across Panama, the Dominican Republic, South Africa, and Mozambique between 2012 and 2014...
January 15, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29334800/research-progress-of-self-assembled-nanogel-and-hybrid-hydrogel-systems-based-on-pullulan-derivatives
#6
Tao Zhang, Ruyi Yang, Shengnan Yang, Jibin Guan, Dong Zhang, Yan Ma, Hongzhuo Liu
Polymer nano-sized hydrogels (nanogels) as drug delivery carriers have been investigated over the last few decades. Pullulan, a nontoxic and nonimmunogenic hydrophilic polysaccharide derived from fermentation of black yeast like Aureobasidium pullulans with great biocompatibility and biodegradability, is one of the most attractive carriers for drug delivery systems. In this review, we describe the preparation, characterization, and 'switch-on/off' mechanism of typical pullulan self-assembled nanogels (self-nanogels), and then introduce the development of hybrid hydrogels that are numerous resources applied for regenerative medicine...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29331806/unifying-in%C3%A2-vitro-and-in%C3%A2-vivo-ivt-mrna-expression-discrepancies-in-skeletal-muscle-via-mechanotransduction
#7
Sushma M Bhosle, Kristin H Loomis, Jonathan L Kirschman, Emmeline L Blanchard, Daryll A Vanover, Chiara Zurla, Damien Habrant, Darin Edwards, Patrick Baumhof, Bruno Pitard, Philip J Santangelo
The translational efficiency of an in vitro transcribed (IVT) mRNA was measured upon delivery to primary skeletal muscle cells and to a mouse model system, towards the development of a predictive in vitro assay for the screening and validation of intramuscular mRNA-based vaccines. When IVT mRNA was delivered either naked or complexed with novel aminoglycoside-based delivery vehicles, significant differences in protein expression in vitro and in vivo were observed. We hypothesized that this previously anticipated discrepancy was due to differences in the mechanism of IVT mRNA endosomal entry and release following delivery...
January 6, 2018: Biomaterials
https://www.readbyqxmd.com/read/29326426/mrna-vaccines-a-new-era-in-vaccinology
#8
REVIEW
Norbert Pardi, Michael J Hogan, Frederick W Porter, Drew Weissman
mRNA vaccines represent a promising alternative to conventional vaccine approaches because of their high potency, capacity for rapid development and potential for low-cost manufacture and safe administration. However, their application has until recently been restricted by the instability and inefficient in vivo delivery of mRNA. Recent technological advances have now largely overcome these issues, and multiple mRNA vaccine platforms against infectious diseases and several types of cancer have demonstrated encouraging results in both animal models and humans...
January 12, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29325699/co-delivery-of-tumor-antigen-and-dual-toll-like-receptor-ligands-into-dendritic-cell-by-silicon-microparticle-enables-efficient-immunotherapy-against-melanoma
#9
Motao Zhu, Xilai Ding, Ruifang Zhao, Xuewu Liu, Haifa Shen, Chunmei Cai, Mauro Ferrari, Helen Y Wang, Rong-Fu Wang
Despite the importance and promise of cancer vaccines for broader prevention and treatment of cancer, limited clinical responses are observed, suggesting that key rational designs are required for inducing potent immune responses against cancer. Here we report a mesoporous silicon vector (MSV) as a multi-functional microparticle for formulating an efficient cancer vaccine composed of B16 melanoma derived-tyrosinase related protein 2 (TRP2) peptide and dual toll-like receptor (TLR) agonists. We demonstrated that MSV microparticles protected the peptide from rapid degradation for prolonged antigen presentation to immune cells...
January 8, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29324805/intranasal-vaccination-with-m2e5x-virus-like-particles-induces-humoral-and-cellular-immune-responses-conferring-cross-protection-against-heterosubtypic-influenza-viruses
#10
Young-Tae Lee, Eun-Ju Ko, Youri Lee, Ki-Hye Kim, Min-Chul Kim, Yu-Na Lee, Sang-Moo Kang
Current influenza vaccines do not provide broad cross-protection. Here, we report that intranasal vaccination with virus-like particles containing the highly conserved multiple ectodomains of matrix protein 2 (M2e5x VLP) of influenza virus induces broad cross-protection by M2-specific humoral and cellular immune responses. M2e5x VLP intranasal vaccination prevented severe weight loss, attenuated inflammatory cytokines and cellular infiltrates, and lowered viral loads, and induced germinal center phenotypic B and plasma cells...
2018: PloS One
https://www.readbyqxmd.com/read/29324612/third-trimester-maternal-vaccination-against-pertussis-and-pertussis-antibody-concentrations
#11
Cynthia Abraham, Michael Pichichero, Jesse Eisenberg, Sonali Singh
OBJECTIVE: To compare pertussis antibody concentrations in maternal venous serum (at the time of delivery) and umbilical cord arterial serum among women vaccinated with the tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine from either 27-30 6/7 weeks of gestation or from 31-35 6/7 weeks of gestation. METHODS: We conducted a prospective cohort study of pregnant women divided into two groups based on when Tdap was administered: 27-30 6/7 weeks of gestation and 31-35 6/7 weeks of gestation...
January 9, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29324304/injectable-polypeptide-hydrogel-for-dual-delivery-of-antigen-and-tlr3-agonist-to-modulate-dendritic-cells-in%C3%A2-vivo-and-enhance-potent-cytotoxic-t-lymphocyte-response-against-melanoma
#12
Huijuan Song, Pingsheng Huang, Jinfeng Niu, Gaona Shi, Chuangnian Zhang, Deling Kong, Weiwei Wang
Transplantation of immune cells manipulated in vitro to dictate immune responses in the body is promising in cancer immunotherapy. However, this approach suffers from low cell survival after administration, insufficient cell homing to lymph nodes, and off-target. Here we demonstrate an injectable and self-assembled poly(l-valine) hydrogel as the delivery carrier of cargoes including antigen and immunopotentiator for DCs modulation. Our results indicate the vaccine formulation composed of tumor cell lysates (TCL), TLR3 agonist, poly(I:C) and polypeptide hydrogel can robustly recruit, activate and mature DCs in vitro and in vivo by sustained release of TCL and poly(I:C)...
January 3, 2018: Biomaterials
https://www.readbyqxmd.com/read/29323913/nanoparticles-with-cd44-targeting-and-ros-triggering-property-as-effective-in-vivo-antigen-delivery-system
#13
Xiaoyu Liang, Xuanling Li, Jianwei Duan, Youlu Chen, Xiaoli Wang, Liyun Pang, Deling Kong, Bing Song, Chen Li, Jing Yang
Currently, development of subunit vaccine based on recombinant antigens or peptides has gradually become an important alternative option for traditional vaccine. However, induction of potent immune response with desired efficacy remains a major challenge. The nanoparticle-based antigen delivery system has been considered a potential carrier system to improve the efficacy of subunit vaccine. In the present study, we have designed an immune-stimulatory delivery system by conjugating three-armed PLGA to PEG via the peroxalate ester bond which is sensitive to hydrogen peroxide (H2O2), a major reactive oxygen species (ROS)...
January 11, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29321308/sustained-specific-and-cross-reactive-t-cell-responses-to-zika-and-dengue-viruses-ns3-in-west-africa
#14
Bobby Brooke Herrera, Wen-Yang Tsai, Charlotte A Chang, Donald J Hamel, Wei-Kung Wang, Yichen Lu, Souleymane Mboup, Phyllis J Kanki
Recent studies on the role of T cells in Zika virus (ZIKV) infection have shown that T cell responses to Asian ZIKV infection are important for protection, and that previous Dengue virus (DENV) exposure amplifies the protective T cell response to Asian ZIKV. Human T cell responses to African ZIKV infection, however, remain unexplored. Here, we utilized the modified anthrax toxin delivery system to develop a flavivirus ELISPOT. Using human ZIKV and DENV samples from Senegal, West Africa, our results demonstrate specific and cross-reactive T cell responses to nonstructural protein 3 (NS3)...
January 10, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29319882/oral-myeloid-cells-uptake-allergoids-coupled-to-mannan-driving-th1-treg-responses-upon-sublingual-delivery-in-mice
#15
Irene Soria, Juan López-Relaño, Marcos Viñuela, José-Ignacio Tudela, Alba Angelina, Cristina Benito-Villalvilla, Carmen M Díez-Rivero, Bárbara Cases, Ana I Manzano, Enrique Fernández-Caldas, Miguel Casanovas, Oscar Palomares, José L Subiza
BACKGROUND: Polymerized allergoids coupled to nonoxidized mannan (PM-allergoids) may represent novel vaccines targeting dendritic cells (DCs). PM-allergoids are better captured by DCs than native allergens and favor Th1/Treg cell responses upon subcutaneous injection. Herein we have studied in mice the in vivo immunogenicity of PM-allergoids administered sublingually in comparison to native allergens. METHODS: Three immunization protocols (4-8 weeks long) were used in Balb/c mice...
January 10, 2018: Allergy
https://www.readbyqxmd.com/read/29318526/evaluation-of-the-protection-provided-by-hepatitis-b-vaccination-in-india
#16
Jacob Puliyel, Pathik Naik, Ashish Puliyel, Kishore Agarwal, Vandana Lal, Nimmi Kansal, Devki Nandan, Vikas Tripathi, Prashant Tyagi, Saroj K Singh, Rajeev Srivastava, Utkarsh Sharma, V Sreenivas
OBJECTIVE: In India, Hepatitis B vaccination is recommended at 6 wk except for hospital-deliveries. The authors examined protection afforded by the birth dose. METHODS: A case-control study was done. HBsAg and HBcAb were tested in 2671 children, 1 to 5 y and HBsAb was evaluated in a subset of 1413 children. Vaccination history was recorded. Cases were HBsAg carriers. In another analysis, children who got infected (HBsAg and/or HBcAb positive) were considered as cases...
January 10, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29313458/clinician-perspectives-on-strategies-to-improve-patient-maternal-immunization-acceptability-in-obstetrics-and-gynecology-practice-settings
#17
Paula M Frew, Laura A Randall, Fauzia Malik, Rupali Lamaye, Andrew Wilson, Sean T O'Leary, Daniel Salmon, Meghan Donnelly, Kevin Ault, Matthew Z Dudley, Vincent L Fenimore, Saad B Omer
Pregnancy is an ideal time to communicate with women about vaccines for themselves and their infants, yet maternal immunization rates remain suboptimal. This study aimed to identify clinic, provider, and staff-related attributes and facilitators to be utilized for a comprehensive vaccine intervention in ob-gyn clinical settings. We conducted in-depth interviews with 24 providers, both healthcare providers (e.g., physicians, nurse practitioners, midwives) and practice managers, from urban and suburban ob-gyn practices in Georgia and Colorado about their immunization attitudes, practices, and patient experiences...
January 9, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29306001/nanoparticulate-vaccine-inhibits-tumor-growth-via-improved-t-cell-recruitment-into-melanoma-and-huher2-breast-cancer
#18
Eva Zupančič, Caterina Curato, Jung-Seok Kim, Eilam Yeini, Ziv Porat, Ana S Viana, Anat Globerson-Levin, Tova Waks, Zelig Eshhar, João N Moreira, Ronit Satchi-Fainaro, Lea Eisenbach, Steffen Jung, Helena F Florindo
Nanoparticulate vaccines are promising tools to overcome cancer immune evasion. However, a deeper understanding on nanoparticle-immune cell interactions and treatments regime are required for optimal efficacy. We provide a comprehensive study of treatment schedules and mode of antigen-association to nanovaccines on the modulation of T cell immunity in vivo, under steady-state and tumor-bearing mice. The coordinated delivery of antigen and two adjuvants (Monophosphoryl lipid A, oligodeoxynucleotide cytosine-phosphate-guanine motifs (CpG)) by nanoparticles was crucial for dendritic cell activation...
January 3, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29304745/characteristics-of-wild-polio-virus-outbreak-investigation-and-response-in-ethiopia-in-2013-2014-implications-for-prevention-of-outbreaks-due-to-importations
#19
Ayesheshem Ademe Tegegne, Fiona Braka, Meseret Eshetu Shebeshi, Aron Kassahun Aregay, Berhane Beyene, Amare Mengistu Mersha, Mohammed Ademe, Abdulahi Muhyadin, Dadi Jima, Abyot Bekele Wyessa
BACKGROUND: Ethiopia joined the Global Polio Eradication Initiative (GPEI) in 1996, and by the end of December 2001 circulation of indigenous Wild Polio Virus (WPV) had been interrupted. Nonetheless, the country experienced multiple importations during 2004-2008, and in 2013. We characterize the 2013 outbreak investigations and response activities, and document lessons learned. METHOD: The data were pulled from different field investigation reports and from the national surveillance database for Acute Flaccid Paralysis (AFP)...
January 5, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29304063/expression-of-human-immunodeficiency-virus-type-1-hiv-1-coat-protein-genes-in-plants-using-cotton-leaf-curl-multan-betasatellite-based-vector
#20
Elham Ataie Kachoie, Seyed Ali Akbar Behjatnia, Sara Kharazmi
It has already been demonstrated that a betasatellite associated with cotton leaf curl Multan virus (CLCuMB) can be used as a plant and animal gene delivery vector to plants. To examine the ability of CLCuMB as a tool to transfer coat protein genes of HIV-1 to plants, two recombinant CLCuMB constructs in which the CLCuMB βC1 ORF was replaced with two HIV-1 genes fractions including a 696 bp DNA fragment related to the HIV-1 p24 gene and a 1501 bp DNA fragment related to the HIV-1 gag gene were constructed...
2018: PloS One
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