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Lung cancer MRI

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https://www.readbyqxmd.com/read/29159957/evaluating-performance-of-a-user-trained-mr-lung-tumor-autocontouring-algorithm-in-the-context-of-intra-and-inter-observer-variations
#1
Eugene Yip, Jihyun Yun, Zsolt Gabos, Sarah Baker, Don Yee, Keith Wachowicz, Satyapal Rathee, B Gino Fallone
PURPOSE: Real-time tracking of lung tumors using magnetic resonance imaging (MRI) has been proposed as a potential strategy to mitigate the ill-effects of breathing motion in radiation therapy. Several autocontouring methods have been evaluated against a "gold standard" of a single human expert user. However, contours drawn by experts have inherent intra- and inter-observer variations. In this study, we aim to evaluate our user-trained autocontouring algorithm with manually drawn contours from multiple expert users, and to contextualize the accuracy of these autocontours within intra- and inter- observer variations...
November 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/29159180/the-influence-of-serum-prostate-specific-antigen-on-the-accuracy-of-magnetic-resonance-imaging-targeted-biopsy-versus-saturation-biopsy-in-patients-with-previous-negative-biopsy
#2
Chao-Hsiang Chang, Hung-Chieh Chiu, Wei-Ching Lin, Tzu-Lung Ho, Han Chang, Yi-Huei Chang, Chi-Ping Huang, Hsi-Chin Wu, Chi-Rei Yang, Po-Fan Hsieh
Objective: We compared the prostate cancer (PCa) detection rates of targeted biopsy (TB) and saturation biopsy (SB) in patients with previous negative biopsy and the accuracy of TB and SB stratified by different serum prostate-specific antigen (PSA) levels. Materials and Methods: Overall 185 patients were enrolled. In the magnetic resonance imaging (MRI) group, 65 men underwent TB and SB. In the control group, 120 men underwent SB alone. The primary outcome was the difference in PCa detection rate between the MRI group and control group...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29157382/diagnostic-imaging-and-newer-modalities-for-thoracic-diseases-pet-computed-tomographic-imaging-and-endobronchial-ultrasound-for-staging-and-its-implication-for-lung-cancer
#3
REVIEW
Sarah J Counts, Anthony W Kim
Modalities to detect and characterize lung cancer are generally divided into those that are invasive [endobronchial ultrasound (EBUS), esophageal ultrasound (EUS), and electromagnetic navigational bronchoscopy (ENMB)] versus noninvasive [chest radiography (CXR), computed tomography (CT), positron emission tomography (PET), and magnetic resonance imaging (MRI)]. This chapter describes these modalities, the literature supporting their use, and delineates what tests to use to best evaluate the patient with lung cancer...
January 2018: PET Clinics
https://www.readbyqxmd.com/read/29142626/resection-and-observation-for-brain-metastasis-without-prompt-postoperative-radiation-therapy
#4
Tae-Wook Song, In-Young Kim, Shin Jung, Tae-Young Jung, Kyung-Sub Moon, Woo-Youl Jang
Objective: Total resection without consecutive postoperative whole brain radiation therapy is indicated for patients with a single or two sites of brain metastasis, with close follow-up by serial magnetic resonance imaging (MRI). In this study, we explored the effectiveness, usefulness, and safety of this follow-up regimen. Methods: From January 2006 to December 2015, a total of 109 patients (76 males, 33 females) underwent tumor resection as the first treatment for brain metastases (97 patients with single metastases, 12 with two metastases)...
November 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/29139055/downstream-breast-imaging-following-screening-mammography-in-medicare-patients-with-advanced-cancer-a-population-based-study
#5
Gelareh Sadigh, Richard Duszak, Kevin C Ward, Renjian Jiang, Jeffrey M Switchenko, Kimberly E Applegate, Ruth C Carlos
BACKGROUND: Screening tests are generally not recommended in patients with advanced cancer and limited life expectancy. Nonetheless, screening mammography still occurs and may lead to follow-up testing. OBJECTIVE: We assessed the frequency of downstream breast imaging following screening mammography in patients with advanced colorectal or lung cancer. DESIGN: Population-based study. PARTICIPANTS: The study included continuously enrolled female fee-for-service Medicare beneficiaries ≥65 years of age with advanced colorectal (stage IV) or lung (stage IIIB-IV) cancer reported to a Surveillance, Epidemiology, and End Results (SEER) registry between 2000 and 2011...
November 14, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29137032/non-hodgkin-lymphoma-of-multiple-extranodal-involvement-seen-on-mri-fdg-pet-ct-scans-a-case-report
#6
Shan Wang, Meng Meng, Qiuhu Wang, Kai Xu
RATIONALE: Anaplastic large cell lymphoma (ALCL) is a rare type of non-Hodgkin lymphoma (NHL). The most common extranodal sites of ALCL are skin, subcutaneous tissue, bone, lung, and gastrointestinal organs. This study reports a case of ALCL with multiple extranodal involvement, especially the whole body skeletal muscles, with the aim to share the imaging features of the ALCL including magnetic resonance imaging (MRI) and 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET-CT)...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29125923/prophylactic-cranial-irradiation-for-extensive-small-cell-lung-cancer
#7
Steven E Schild, Terence T Sio, Thomas B Daniels, Stephen G Chun, Dirk Rades
Small-cell lung cancer (SCLC) has a high predilection for metastasizing to the brain after chemotherapy. This has been blamed on the blood-brain barrier, which prevents chemotherapy from penetrating into the brain, thus creating a sanctuary site. It has been estimated that up to three quarters of patients with SCLC will eventually develop brain metastases. This led investigators to administer prophylactic cranial irradiation (PCI) to decrease this risk. Several trials were performed in patients with SCLC after initial therapy (chemotherapy with or without thoracic radiotherapy) that compared the outcomes of PCI versus no PCI...
November 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29125427/the-surgical-treatment-of-metastatic-spine-tumors-within-the-intramedullary-compartment
#8
Ben A Strickland, Ian E McCutcheon, Indro Chakrabarti, Laurence D Rhines, Jeffrey S Weinberg
OBJECTIVE Metastasis to the spinal cord is rare, and optimal management of this disease is unclear. The authors investigated this issue by analyzing the results of surgical treatment of spinal intramedullary metastasis (IM) at a major cancer center. METHODS The authors retrospectively reviewed the medical records of 13 patients who underwent surgery for IM. Patients had renal cell carcinoma (n = 4), breast carcinoma (n = 3), melanoma (n = 2), non-small cell lung cancer (n = 1), sarcoma (n = 1), adenoid cystic carcinoma (n = 1), and cervical cancer (n = 1)...
November 10, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29123008/reproducibility-of-mr-based-attenuation-maps-in-pet-mri-and-the-impact-on-pet-quantification-in-lung-cancer
#9
Anders Olin, Claes N Ladefoged, Natasha H Langer, Sune H Keller, Johan O Löfgren, Adam E Hansen, Andreas Kjær, Seppo W Langer, Barbara M Fischer, Flemming L Andersen
AIM: Quantitative positron emission tomography/magnetic resonance imaging (PET/MRI) is dependent upon reliable and reproducible MR-based attenuation correction (MR-AC). In this study we evaluated the quality of current vendor-provided thoracic MR-AC maps, and further investigated the reproducibility of these in terms of their impact on fluorodeoxyglucose (FDG)-PET quantification in patients with non-small cell lung cancer (NSCLC). MATERIAL AND METHODS: Eleven patients with inoperable NSCLC underwent two to five thoracic PET/MRI scan-rescan examinations within 22 days...
November 9, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29121075/functional-evaluation-of-therapeutic-response-of-hcc827-lung-cancer-to-bevacizumab-and-erlotinib-targeted-therapy-using-dynamic-contrast-enhanced-and-diffusion-weighted-mri
#10
Yi-Fang Chen, Ang Yuan, Kuan-Hung Cho, Yi-Chien Lu, Mark Yen-Ping Kuo, Jyh-Horng Chen, Yeun-Chung Chang
This study aimed to investigate the therapeutic responses of lung cancer mice models with adenocarcinoma HCC827 (gefitinib sensitive) and HCC827R (gefitinib resistant) to the epidermal growth factor receptor-tyrosine kinase inhibitor erlotinib alone and in combination with the anti-angiogenesis agent bevacizumab using dynamic contrast enhanced (DCE) and diffusion-weighted MRI. In the HCC827 model, temporal changes in DCE-MRI derived parameters (Ktrans, kep, and iAUC90) and apparent diffusion coefficient (ADC) were significantly correlated with tumor size...
2017: PloS One
https://www.readbyqxmd.com/read/29114603/audiovisual-biofeedback-guided-breath-hold-improves-lung-tumor-position-reproducibility-and-volume-consistency
#11
Danny Lee, Peter B Greer, Carminia Lapuz, Joanna Ludbrook, Perry Hunter, Jameen Arm, Sean Pollock, Kuldeep Makhija, Ricky T O'Brien, Taeho Kim, Paul Keall
Purpose: Respiratory variation can increase the variability of tumor position and volume, accounting for larger treatment margins and longer treatment times. Audiovisual biofeedback as a breath-hold technique could be used to improve the reproducibility of lung tumor positions at inhalation and exhalation for the radiation therapy of mobile lung tumors. This study aimed to assess the impact of audiovisual biofeedback breath-hold (AVBH) on interfraction lung tumor position reproducibility and volume consistency for respiratory-gated lung cancer radiation therapy...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29108860/fibrosis-imaging-current-concepts-and-future-directions
#12
Maike Baues, Anshuman Dasgupta, Josef Ehling, Jai Prakash, Peter Boor, Frank Tacke, Fabian Kiessling, Twan Lammers
Fibrosis plays an important role in many different pathologies. It results from tissue injury, chronic inflammation, autoimmune reactions and genetic alterations, and it is characterized by the excessive deposition of extracellular matrix components. Biopsies are routinely employed for fibrosis diagnosis, but they suffer from several drawbacks, including their invasive nature, sampling variability and limited spatial information. To overcome these limitations, multiple different imaging tools and technologies have been evaluated over the years, including x-ray imaging, computed tomography (CT), ultrasound (US), magnetic resonance imaging (MRI), positron emission tomography (PET) and single-photon emission computed tomography (SPECT)...
November 3, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29107823/photodynamic-therapy-for-an-iris-metastasis-from-pulmonary-adenocarcinoma
#13
Yanyan Chen, Yuedong Hu
Uveal metastasis is the most common intraocular malignancy. Lung cancer is one of the most common malignancies that metastasize to uvea. Iris involvement is rarely reported. Here we report a case of iris metastasis from pulmonary adenocarcinoma that was treated with photodynamic therapy (PDT). A 65-year-old Chinese man was referred to our hospital for iris white neoplasm and blurred vision for 2 weeks in his right eye. His accepted pulmonary lobectomy, radiotherapy and chemotherapy for pulmonary adenocarcinoma 1year ago and liver metastases were found 2 months earlier...
October 28, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29098882/ph-and-thermo-sensitive-mtx-loaded-magnetic-nanocomposites-synthesis-characterization-and-in-vitro-studies-on-a549-lung-cancer-cell-and-mr-imaging
#14
Masoud Farshbaf, Roya Salehi, Nasim Annabi, Rovshan Khalilov, Abolfazl Akbarzadeh, Soodabeh Davaran
In current study we proposed a facile method for fabrication of multifunctional pH- and thermo sensitive magnetic nanocamposites (MNCs) as a theranostic agent employing in targeted drug delivery and magnetic resonance imaging (MRI). To this end, we decorated Fe3O4 magnetic nanoparticles (MNPs) with N,N-dimethylaminoethyl methacrylate (DMAEMA) and N-isopropylacrylamide (NIPAAm), best known for their pH- and thermo sensitive properties, respectively. We also conjugated mesoporous silica nanoparticles (MSNs) to polymer matrix acting as drug container to enhance the drug encapsulation efficacy...
November 3, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29070999/treatment-of-leptomeningeal-metastases-in-a-patient-with-non-small-cell-lung-cancer-harboring-egfr-t790m-mutation
#15
Hardy Niu, Junle Zhou, Harvinder Maan, Maurie Markman, Jiaxin Niu
BACKGROUND: Leptomeningeal metastasis (LM) is an uncommon complication in patients with solid tumors, associated with poor survival. However, LM appears to be more frequent in lung cancer patients with EGFR mutations, posing a unique clinical challenge to treating physicians. CASE PRESENTATION: We report the case of a 68-year-old Asian man with metastatic lung adenocarcinoma harboring an EGFR L858R mutation, which was initially treated with gefitinib. He developed disease progression 1 year later...
September 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/29059917/a-radiomics-evaluation-of-2d-and-3d-mri-texture-features-to-classify-brain-metastases-from-lung-cancer-and-melanoma
#16
Rafael Ortiz-Ramon, Andres Larroza, Estanislao Arana, David Moratal
Brain metastases are occasionally detected before diagnosing their primary site of origin. In these cases, simple visual examination of medical images of the metastases is not enough to identify the primary cancer, so an extensive evaluation is needed. To avoid this procedure, a radiomics approach on magnetic resonance (MR) images of the metastatic lesions is proposed to classify two of the most frequent origins (lung cancer and melanoma). In this study, 50 T1-weighted MR images of brain metastases from 30 patients were analyzed: 27 of lung cancer and 23 of melanoma origin...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29054899/lung-adenocarcinoma-metastastic-lesion-in-the-internal-auditory-meatus
#17
Eugene Hung Chih Wong, Daniel Bodmer, Nora Tetter, Yves Brand
Metastasis to the cerebellopontine angle (CPA) or internal auditory meatus (IAM) is rare.We report a rare case of a 69-year-old woman with metastatic lung adenocarcinoma, who presented with 2 weeks history of left-sided hearing loss and progressively worsening vertigo. Examination revealed a left-sided facial nerve palsy while pure tone audiometry (PTA) showed a new left-sided deafness. MRI showed a new enhancing soft tissue lesion in the left IAM, highly suspicious of new metastases from her progressive lung cancer, which contributed to her neuro-otological symptoms...
October 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29038584/dual-drug-containing-core-shell-nanoparticles-for-lung-cancer-therapy
#18
Jyothi U Menon, Aneetta Kuriakose, Roshni Iyer, Elizabeth Hernandez, Leah Gandee, Shanrong Zhang, Masaya Takahashi, Zhang Zhang, Debabrata Saha, Kytai T Nguyen
Late-stage diagnosis of lung cancer occurs ~95% of the time due to late manifestation of its symptoms, necessitating rigorous treatment following diagnosis. Existing treatment methods are limited by lack of specificity, systemic toxicity, temporary remission, and radio-resistance in lung cancer cells. In this research, we have developed a folate receptor-targeting multifunctional dual drug-loaded nanoparticle (MDNP) containing a poly(N-isopropylacrylamide)-carboxymethyl chitosan shell and poly lactic-co-glycolic acid (PLGA) core for enhancing localized chemo-radiotherapy to effectively treat lung cancers...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29036003/68ga-prostate-specific-membrane-antigen-avid-tubercular-lesions-mimicking-prostate-cancer-metastasis-on-simultaneous-prostate-specific-membrane-antigen-pet-mri
#19
Aashim Ahuja, Sangeeta Taneja, Kiran Thorat, Amarnath Jena
Ga-prostate-specific membrane antigen (PSMA) has gained increasing interest as a target molecule in imaging of prostate cancer because of its selective overexpression in local prostate cancer lesions and metastasis. We report a case of a 62-year-old man with raised serum prostate-specific antigen levels who presented for Ga-PSMA HBED-CC simultaneous PET/MRI for prostate cancer evaluation. A PSMA-nonavid PI-RADS 5 (Prostate Imaging-Reporting and Data System) lesion was confirmed as adenocarcinoma on histopathology...
December 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29029832/tumour-auto-contouring-on-2d-cine-mri-for-locally-advanced-lung-cancer-a-comparative-study
#20
Martin F Fast, Björn Eiben, Martin J Menten, Andreas Wetscherek, David J Hawkes, Jamie R McClelland, Uwe Oelfke
BACKGROUND AND PURPOSE: Radiotherapy guidance based on magnetic resonance imaging (MRI) is currently becoming a clinical reality. Fast 2d cine MRI sequences are expected to increase the precision of radiation delivery by facilitating tumour delineation during treatment. This study compares four auto-contouring algorithms for the task of delineating the primary tumour in six locally advanced (LA) lung cancer patients. MATERIAL AND METHODS: Twenty-two cine MRI sequences were acquired using either a balanced steady-state free precession or a spoiled gradient echo imaging technique...
October 10, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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