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https://www.readbyqxmd.com/read/28806249/epidural-metastases-from-follicular-thyroid-cancer-mimicking-meningiomas-in-68ga-dotatate-pet
#1
Marcus Unterrainer, Harun Ilhan, Andrei Todica, Peter Bartenstein, Nathalie Lisa Albert
We report a woman with multifocal lesions suggestive of meningiomas in MRI, which also presented with high Ga-DOTATATE uptake in PET, a finding characteristic for meningioma. A whole-body staging due to a pathological fracture revealed multiple neoplastic lesions throughout the body without detection of a primary site. Subsequent pathological workup of a lung lesion revealed multifocal metastases from follicular thyroid cancer despite thyroidectomy 10 years ago (without pathological finding), and posttreatment scans after radioiodine therapy confirmed the multiple brain lesions to be metastases as well...
August 12, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28803798/radiosynthesis-and-preclinical-pet-evaluation-of-89-zr-nivolumab-bms-936558-in-healthy-non-human-primates
#2
Erin L Cole, Joonyoung Kim, David J Donnelly, R Adam Smith, Daniel Cohen, Virginie Lafont, Paul E Morin, Richard Y-C Huang, Patrick L Chow, Wendy Hayes, Samuel Bonacorsi
Cancer immunotherapy, unlike traditional cytotoxic chemotherapeutic treatments, engages the immune system to identify cancer cells and stimulate immune responses. The Programmed Death-1 (PD-1) protein is an immunoinhibitory receptor expressed by activated cytotoxic T-lymphocytes (CTL) that seek out and destroy cancer cells. Multiple cancer types express and upregulate the Programmed Death-Ligand 1 (PD-L1) and 2 (PD-L2) which bind to PD-1 as an immune escape mechanism. Nivolumab is a fully human IgG4 anti-PD-1 monoclonal antibody (mAb) approved for treatment of multiple cancer types...
August 4, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28800298/impact-of-field-number-and-beam-angle-on-functional-image-guided-lung-cancer-radiotherapy-planning
#3
Bilal A Tahir, Chris M Bragg, Jim M Wild, James A Swinscoe, Sarah E Lawless, Kerry A Hart, Matthew Q Hatton, Rob H Ireland
To investigate the effect of beam angles and field number on functionally-guided intensity modulated radiotherapy (IMRT) normal lung avoidance treatment plans that incorporate hyperpolarised helium-3 magnetic resonance imaging ((3)He MRI) ventilation data. Eight non-small cell lung cancer patients had pre-treatment (3)He MRI that was registered to inspiration breath-hold radiotherapy planning computed tomography. IMRT plans that minimised the volume of total lung receiving  ⩾20 Gy (V20) were compared with plans that minimised (3)He MRI defined functional lung receiving  ⩾20 Gy (fV20)...
August 11, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28790264/-a-case-of-lung-adenocarcinoma-presenting-with-leptomeningeal-carcinomatosis-successfully-treated-with-afatinib-after-erlotinib-induced-hepatotoxicity
#4
Hiroaki Tanaka, Minehiko Inomata, Ryuji Hayashi, Kazuki Shimokawa, Kotaro Tokui, Seisuke Okazawa, Kenta Kambara, Toru Yamada, Toshiro Miwa, Tatsuhiko Kashii, Hirofumi Konishi, Kazuyuki Tobe
A 65-year-old man was diagnosed with leptomeningeal carcinomatosis based on the findings of cerebrospinal fluid cytology and magnetic resonance imaging(MRI).Treatment with erlotinib and bevacizumab was initiated, and partial improvement in consciousness and MRI findings were obtained.However, it was difficult to continue the treatment because of elevation in levels of liver enzymes and melena.We switched the treatment to afatinib monotherapy, and his consciousness improved immediately.Progression -free survival and overall survival from the initiation of the treatment with afatinib were 7 and 9...
July 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28783541/increasing-frequency-of-non-smoking-lung-cancer-presentation-of-patients-with-early-disease-to-a-tertiary-institution-in-the-uk
#5
Maria Elena Cufari, Chiara Proli, Paulo De Sousa, Hilgardt Raubenheimer, May Al Sahaf, Hema Chavan, Lynn Shedden, Zakiyah Niwaz, Maria Leung, Andrew G Nicholson, Vladimir Anikin, Emma Beddow, Niall McGonigle, Michael E Dusmet, Simon Jordan, George Ladas, Eric Lim
BACKGROUND: Never-smokers with lung cancer often present late as there are no established aetiological risk factors. The aim of the study is to define the frequency over time and characterise clinical features of never-smokers presenting sufficiently early to determine if it is possible to identify patients at risk. METHODS: We retrospectively analysed data from a prospectively collected database of patients who underwent surgery. The frequency was defined as number of never-smokers versus current and ex-smokers by year...
August 3, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28781798/paraneoplastic-limbic-encephalitis-with-late-onset-magnetic-resonance-imaging-findings-a-case-report
#6
Yoshiya Tsunoda, Takumi Kiwamoto, Shinsuke Homma, Yuuki Yabuuchi, Haruna Kitazawa, Toshihiro Shiozawa, Kensuke Nakazawa, Takashi Hosaka, Kazuhiro Ishii, Akiko Ishii, Akira Tamaoka, Nobuyuki Hizawa
Paraneoplastic limbic encephalitis (PLE), a paraneoplastic neurological syndrome (PNS), is a rare nervous system disorder that results from the indirect effects of tumors and is commonly associated with small-cell lung cancer (SCLC). Previous studies have reported that magnetic resonance imaging (MRI) may be useful for diagnosing LE. Temporal lobe abnormalities are observed using T2-weighted and fluid-attenuated inversion recovery sequences; however, such abnormalities are detected in only 60% of patients with PLE...
August 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28772286/prevalence-of-cancer-at-baseline-screening-in-the-national-cancer-institute-li-fraumeni-syndrome-cohort
#7
Phuong L Mai, Payal P Khincha, Jennifer T Loud, Rosamma M DeCastro, Renée C Bremer, June A Peters, Chia-Ying Liu, David A Bluemke, Ashkan A Malayeri, Sharon A Savage
Importance: Establishment of an optimal cancer surveillance program is important to reduce cancer-related morbidity and mortality in individuals with Li-Fraumeni syndrome, a rare, highly penetrant cancer predisposition syndrome. Objective: To determine the feasibility and efficacy of a comprehensive cancer screening regimen in Li-Fraumeni syndrome, using multiple radiologic techniques, including rapid whole-body magnetic resonance imaging (MRI) and laboratory measurements...
August 3, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28740677/assessment-of-thoracic-vasculature-in-patients-with-central-bronchogenic-carcinoma-by-unenhanced-magnetic-resonance-angiography-comparison-between-2d-free-breathing-truefisp-2d-breath-hold-truefisp-and-3d-respiratory-triggered-space
#8
Lili Wang, Peng Lv, Shuohui Yang, Mengsu Zeng, Jiang Lin
BACKGROUND: Preoperative assessment of the integrity of major thoracic vessels in central bronchogenic carcinoma is vital for tumor staging and treatment planning. Contrast-enhanced CT is currently the first choice of modality for this purpose in clinical practice with limitations including exposure to ionizing radiation and the use of iodinated contrast material. MRI has been increasingly employed for the staging of lung cancer. More recently, unenhanced magnetic resonance angiography (MRA) which is totally non-invasive and contrast-free has been reported able to show thoracic vessels...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28734552/prevalence-and-predictive-value-of-pre-therapeutic-sarcopenia-in-cancer-patients-a-systematic-review
#9
REVIEW
Frédéric Pamoukdjian, Thierry Bouillet, Vincent Lévy, Michael Soussan, Laurent Zelek, Elena Paillaud
BACKGROUND & AIMS: To assess the prevalence of sarcopenia before cancer treatment and its predictive value during the treatment. METHODS: We searched MEDLINE via PubMed for articles published from 2008 to 2016 that reported prospective observational or interventional studies of the prevalence of pre-therapeutic sarcopenia and its consequences in adults with cancer who were 18 years or older. Two independent reviewers selected articles based on titles and/or abstracts before a complete review...
July 13, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28728712/diagnostic-imaging-and-newer-modalities-for-thoracic-diseases-pet-computed-tomographic-imaging-and-endobronchial-ultrasound-for-staging-and-its-implication-for-lung-cancer
#10
REVIEW
Sarah J Counts, Anthony W Kim
Modalities to detect and characterize lung cancer are generally divided into those that are invasive [endobronchial ultrasound (EBUS), esophageal ultrasound (EUS), and electromagnetic navigational bronchoscopy (ENMB)] versus noninvasive [chest radiography (CXR), computed tomography (CT), positron emission tomography (PET), and magnetic resonance imaging (MRI)]. This chapter describes these modalities, the literature supporting their use, and delineates what tests to use to best evaluate the patient with lung cancer...
August 2017: Surgical Clinics of North America
https://www.readbyqxmd.com/read/28717395/brain-imaging-before-primary-lung-cancer-resection-a-controversial-topic
#11
Zoe Hudson, Eveline Internullo, Anthony Edey, Isabel Laurence, Davide Bianchi, Alfredo Addeo
OBJECTIVE: International and national recommendations for brain imaging in patients planned to undergo potentially curative resection of non-small-cell lung cancer (NSCLC) are variably implemented throughout the United Kingdom [Hudson BJ, Crawford MB, and Curtin J et al (2015) Brain imaging in lung cancer patients without symptoms of brain metastases: a national survey of current practice in EnglandClin Radiol https://doi.org/10.1016/j.crad.2015.02.007]. However, the recommendations are not based on high-quality evidence and do not take into account cost implications and local resources...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28709456/analyses-of-distribution-and-dosimetry-of-brain-metastases-in-small-cell-lung-cancer-with-relation-to-the-neural-stem-cell-regions-feasibility-of-sparing-the-hippocampus-in-prophylactic-cranial-irradiation
#12
Lei Zhao, Yan Shen, Jin-Dong Guo, Heng-Le Gu, Wen Yu, Jia-Ming Wang, Chang-Xing Lv, Jun Liu, Xu-Wei Cai, Xiao-Long Fu
BACKGROUND: This work aims to assess the feasibility of selectively sparing the hippocampus during prophylactic cranial irradiation (PCI) for small cell lung cancer (SCLC). METHODS: SCLC patients with brain metastases (BMs) diagnosed with MRI were enrolled. Lesions localized to the neural stem cell (NSC) compartments [subventricular zone (SVZ) or hippocampus] were analyzed. Patients were categorized by the total number of intracranial metastases, the therapy processes and the symptoms...
July 15, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28709170/-leptomeningeal-carcinomatosis-as-a-rare-metastatic-spreading-of-braf-mutated-microsatellite-stable-colon%C3%A2-cancer
#13
Aksana Höblinger, Stephanie Weber, Florian Tschirner, Stefan Kröber, Konrad Streetz
Leptomeningeal carcinomatosis is a rare but serious complication of solid tumors such as melanoma, breast and lung cancer, as well as gastrointestinal carcinomas. Its clinical manifestation is highly variable, presenting as radicular pain with or without neurological deficits, as well as with headaches and hallucinatory irritation symptoms. Leptomeningeal carcinomatosis is often misdiagnosed, which delays treatment. Here we report a rare case of a patient with BRAF-mutated microsatellite stable colon carcinoma with lymphatic and skeletal metastases, who developed neurological symptoms one month after the initial diagnosis of malignancy...
July 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/28705927/incidence-of-brain-metastases-on-follow-up-18-f-fdg-pet-ct-scans-of-non-small-cell-lung-cancer-patients-should-we-include-the-brain
#14
Emily Nia, Linda Garland, Naghmehossadat Eshghi, Benjamin Nia, Ryan Avery, Phillip Kuo
PURPOSE: The brain is the most common site of distant metastasis from lung cancer. Thus MRI of the brain at initial staging is routinely performed, but if this exam is negative a follow-up exam is often not performed. This study evaluates the incidence of asymptomatic brain metastases in non-small cell lung cancer patients detected on follow-uP(18)F- FDG PET/CT scans. MATERIALS AND METHODS: In this IRB approved retrospective review, all vertex to thigh (18)F- FDG PET/CT scans in patients with all subtypes of lung cancer from August 2014 to August 2016 were reviewed...
July 13, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28698444/-a-case-of-central-diabetes-insipidus-that-was-caused-by-pituitary-metastasis-of-lung-adenocarcinoma-and-was-controlled-by-radiation-therapy
#15
Yusuke Izumi, Takeshi Masuda, Shinji Nabeshima, Yasushi Horimasu, Taku Nakashima, Shintaro Miyamoto, Hiroshi Iwamoto, Kazunori Fujitaka, Yuji Murakami, Hironobu Hamada, Yasushi Nagata, Noboru Hattori
BACKGROUND: Pituitary metastasis of lung cancer is rare; however, it often causes diabetes insipidus. Although the majority of such patients are treated with radiation therapy, it remains unclear whether diabetes insipidus can be controlled by radiation therapy. CASE: A 72-year-old man was admitted to our hospital for hemosputum, headache, and polyuria. A chest CT scan showed a 3.0 cm mass in the left upper lobe of his lung. Bronchofiberscopy results confirmed the pathological diagnosis of lung adenocarcinoma...
June 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28693276/examination-of-the-predictive-factors-of-the-response-to-whole-brain-radiotherapy-for-brain-metastases-from-lung-cancer-using-mri
#16
Shuri Aoki, Tomonori Kanda, Noriyuki Matsutani, Nobuhiko Seki, Masafumi Kawamura, Shigeru Furui, Hideomi Yamashita
Previous studies have been conducted on the prognostic factors for overall survival in patients with brain metastases (BMs) following whole brain radiotherapy (WBRT). However, there have been a small number of studies regarding the prognostic factors for the response of tumor to WBRT. The aim of the present study was to identify the predictive factors for the response to WBRT from the point of view of reduction of tumor using magnetic resonance imaging. A retrospective analysis of 62 patients with BMs from primary lung cancer treated with WBRT was undertaken...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28690355/evaluation-of-lung-tumor-motion-management-in-radiation-therapy-with-dynamic-mri
#17
Seyoun Park, Rana Farah, Steven M Shea, Erik Tryggestad, Russell Hales, Junghoon Lee
Surrogate-based tumor motion estimation and tracing methods are commonly used in radiotherapy despite the lack of continuous real time 3D tumor and surrogate data. In this study, we propose a method to simultaneously track the tumor and external surrogates with dynamic MRI, which allows us to evaluate their reproducible correlation. Four MRI-compatible fiducials are placed on the patient's chest and upper abdomen, and multi-slice 2D cine MRIs are acquired to capture the lung and whole tumor, followed by two-slice 2D cine MRIs to simultaneously track the tumor and fiducials, all in sagittal orientation...
February 11, 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/28687923/lapatinib-with-whole-brain-radiotherapy-in-patients-with-brain-metastases-from-breast-and-non-small-cell-lung-cancer-a-phase-ii-study-of-the-hellenic-cooperative-oncology-group-hecog
#18
Christos Christodoulou, Anna Kalogera-Fountzila, Vasilios Karavasilis, George Kouvatseas, Christos N Papandreou, Epaminontas Samantas, Kalliopi Varaki, Georgios Papadopoulos, Mattheos Bobos, Grigorios Rallis, Evangelia Razis, Athina Goudopoulou, Konstantine T Kalogeras, Konstantinos N Syrigos, George Fountzilas
Small molecules, mainly tyrosine kinase inhibitors, are currently used in various malignancies. Lapatinib, a dual inhibitor of EGFR/HER2 tyrosine kinases, has demonstrated effectiveness in brain metastases from HER2-overexpressing breast cancer. It also appears to sensitize EGFR-expressing cell lines to radiation. To evaluate the efficacy of lapatinib in combination with whole brain radiotherapy (WBRT) in patients with brain metastases from non-small cell lung cancer (NSCLC) and breast cancer, as assessed by volumetric analysis by MRI...
July 7, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28684728/a-rare-case-of-sarcomatoid-carcinoma-of-the-lung-with-spine-metastasis-including-a-literature-review
#19
Hafiza Sobia Arshad, Rizwan Ahmed Dudekula, Masooma Niazi, Sandeep Malik, Misbahuddin Khaja
BACKGROUND Sarcomatoid carcinoma is a rare, aggressive, malignant cancer composed of sarcoma and sarcoma-like components, and can occur in different organs such as the thyroid gland, bone, skin, breast, pancreas, liver, urinary tract, and lung. Pulmonary sarcomatoid carcinoma accounts for only a small percentage of lung cancers and has histological variants that include pleomorphic carcinoma, giant cell carcinoma, spindle cell carcinoma, carcinosarcoma, and pulmonary blastoma. CASE REPORT Here, we present a case of sarcomatoid carcinoma in a 63-year-old HIV-positive Hispanic male who presented with back pain, dry cough, and weight loss...
July 7, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28673886/newly-diagnosed-sellar-tumors-in-cancer-patients-a-diagnostic-challenge-and-management-dilemma
#20
Carlos R Goulart, Smita Upadhyay, Leo F S Ditzel Filho, Andre Beer-Furlan, Ricardo L Carrau, Luciano M Prevedello, Daniel M Prevedello
OBJECTIVE: The use of PET CT for staging in cancer patients and the widespread use of MRI led to an increased incidence of incidental sellar mass detection. The imaging findings can be suggestive of a benign pituitary tumor but metastasis can never be completely ruled out with non-invasive work-up. Appropriate diagnosis of these sellar masses is critical as the treatment paradigm might change in the presence of a pituitary metastasis. Moreover, definitive tissue diagnosis might prevent unnecessary radiotherapy to the skull base or even the need for systemic treatment when benign pituitary disease is confirmed...
June 30, 2017: World Neurosurgery
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