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Lung cancer MRI

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https://www.readbyqxmd.com/read/27872484/co-occurrence-of-local-anisotropic-gradient-orientations-collage-a-new-radiomics-descriptor
#1
Prateek Prasanna, Pallavi Tiwari, Anant Madabhushi
In this paper, we introduce a new radiomic descriptor, Co-occurrence of Local Anisotropic Gradient Orientations (CoLlAGe) for capturing subtle differences between benign and pathologic phenotypes which may be visually indistinguishable on routine anatomic imaging. CoLlAGe seeks to capture and exploit local anisotropic differences in voxel-level gradient orientations to distinguish similar appearing phenotypes. CoLlAGe involves assigning every image voxel an entropy value associated with the co-occurrence matrix of gradient orientations computed around every voxel...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27863343/acrometastasis-following-colorectal-cancer-a-case-report-and-review-of-literature
#2
Kozar Agha, Khalid Akbari, Syed Husain Abbas, Simon Middleton, Daniel McGrath
INTRODUCTION: Colorectal cancer commonly metastasises to the liver, peritoneum and lungs. Bony metastases are uncommon in colorectal cancer and in particular metastases to the hands or feet (acrometastasis) are an extremely rare occurrence. CASE PRESENTATION: A 65-year-old male with a colonic malignancy underwent elective anterior resection. Intra-operatively he was found to have a pelvic collection necessitating an end colostomy. Histology confirmed complete Dukes B tumour excision with no evidence of lymph node metastases...
November 10, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27835905/cxcr4-antagonists-suppress-small-cell-lung-cancer-progression
#3
Sanaz Taromi, Gian Kayser, Julie Catusse, Dominik von Elverfeldt, Wilfried Reichardt, Friederike Braun, Wolfgang A Weber, Robert Zeiser, Meike Burger
Small cell lung cancer (SCLC) is an aggressive tumor with poor prognosis due to early metastatic spread and development of chemoresistance. Playing a key role in tumor-stroma interactions the CXCL12-CXCR4 axis may be involved in both processes and thus represent a promising therapeutic target in SCLC treatment. In this study we investigated the effect of CXCR4 inhibition on metastasis formation and chemoresistance using an orthotopic xenograft mouse model. This model demonstrates regional spread and spontaneous distant metastases closely reflecting the clinical situation in extensive SCLC...
November 9, 2016: Oncotarget
https://www.readbyqxmd.com/read/27814824/acr-appropriateness-criteria-%C3%A2-stage-i-breast-carcinoma
#4
Phan Tuong Huynh, Sergy V Lemeshko, Mary C Mahoney, Mary S Newell, Lisa Bailey, Lora D Barke, Carl D'Orsi, Jennifer A Harvey, Mary K Hayes, Peter M Jokich, Su-Ju Lee, Constance D Lehman, Martha B Mainiero, David A Mankoff, Samir B Patel, Handel E Reynolds, M Linda Sutherland, Bruce G Haffty
Stage I breast carcinoma is classified when an invasive breast carcinoma is ≤2 cm in diameter (T1), with no regional (axillary) lymph node metastases (N0) and no distant metastases (M0). The most common sites for metastases from breast cancer are the skeleton, lung, liver, and brain. In general, women and health care professionals prefer intensive screening and surveillance after a diagnosis of breast cancer. Screening protocols include conventional imaging such as chest radiography, bone scan, ultrasound of the liver, and MRI of brain...
November 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/27793323/extramammary-findings-in-diagnostic-breast-magnetic-resonance-imaging-among-patients-with-known-breast-cancer-incidence-and-cost-analysis
#5
Lisa M Hayes, Julia S Frebault, Jeffrey Landercasper, Andrew J Borgert, Choua A Vang, Jeanne M Johnson, Jared H Linebarger
BACKGROUND: Extramammary findings (EMFs) are common on breast magnetic resonance imaging (MRI). METHODS: A retrospective review of breast MRIs in breast cancer patients between January 2009 and December 2014 was performed to identify EMF occurrences, resultant evaluation, and added cost. RESULTS: EMFs were noted in 185 (59%) of 316 MRIs. Overall, 201 new EMFs were identified with 178 (89%) benign and 23 (11%) malignant. New malignant findings included 19 metastatic nodes (18 axillary, 1 internal mammary) and 4 primary malignancies (2 thyroid, 2 lung)...
September 30, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27793056/the-implication-of-tumor-biomarker-ca19-9-in-the-diagnosis-of-intracranial-epidermoid-cyst
#6
Yongjie Wang, Wei Yan, Qun Wu, Gao Chen, Jianmin Zhang
OBJECT: The diagnosis of intracranial epidermoid cyst (IEC) relies solely on MRI, which is time and money consuming. The application of tumor biomarkers in IEC has never been systematically studied. Here we screened a group of commonly used tumor biomarkers to assess their diagnostic value in IEC. RESULTS: Serum tumor biomarkers were assessed in 42 IECs and 42 paired healthy controls. Only serum CA19-9 level was significantly higher in the IEC group (median 20.3U/ml vs...
October 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27790371/total-or-partial-vertebrectomy-for-lung-cancer-invading-the-spine
#7
Soichi Oka, Hiroki Matsumiya, Shuichi Shinohara, Taiji Kuwata, Masaru Takenaka, Yasuhiro Chikaishi, Ayako Hirai, Naoko Imanishi, Koji Kuroda, Sohsuke Yamada, Hidetaka Uramoto, Eiichiro Nakamura, Fumihiro Tanaka
BACKGROUND: Surgery for lung cancer invading the spine remains challenging associated with high morbidity and mortality. However, recent advances in surgical techniques as well as in perioperative care may improve outcomes of lung cancer surgery with vertebrectomy. We describe our surgical approach and assess the outcome lung cancer invading the spine. METHODS: We retrospectively reviewed our recent experiences of lung cancer with vertebral invasion, in which we have performed total or partial vertebrectomy from January 2011 through April 2015...
December 2016: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/27784748/gemcitabine-mechanism-of-action-confounds-early-assessment-of-treatment-response-by-3-deoxy-3-18f-fluorothymidine-in-preclinical-models-of-lung-cancer
#8
Sonja Schelhaas, Annelena Held, Lydia Wachsmuth, Sven Hermann, Davina J Honess, Kathrin Heinzmann, Donna-Michelle Smith, John R Griffiths, Cornelius Faber, Andreas H Jacobs
3'-Deoxy-3'-[(18)F]fluorothymidine positron emission tomography ([(18)F]FLT PET) and diffusion weighted magnetic resonance imaging (DW-MRI) are promising approaches to monitor tumor therapy response. Here, we employed these two imaging modalities to evaluate the response of lung carcinoma xenografts in mice after gemcitabine therapy. Caliper measurements revealed that H1975 xenografts responded to gemcitabine treatment, whereas A549 growth was not affected. In both tumor models uptake of [(18)F]FLT was significantly reduced 6 h after drug administration...
October 26, 2016: Cancer Research
https://www.readbyqxmd.com/read/27776644/hybrid-imaging-for-detection-of-carcinoma-of-unknown-primary-a-preliminary-comparison-trial-of-whole-body-pet-mri-versus-pet-ct
#9
Verena Ruhlmann, Marcus Ruhlmann, Alexander Bellendorf, Johannes Grueneisen, Lino M Sawicki, Hong Grafe, Michael Forsting, Andreas Bockisch, Lale Umutlu
PURPOSE: The aim of this study is to evaluate and compare the diagnostic potential of integrated whole-body [18F]FDG-PET/MRI to [18F]FDG-PET/CT for detection of a potential primary cancer and metastases in patients suspected for cancer of unknown primary (CUP). METHODS: A total of 20 patients (15 male, 5 female, age 53±13 years) suspect for CUP underwent a dedicated head and neck & whole-body [18F]FDG-PET/CT (Biograph mCT 128, Siemens Healthcare) and a subsequent simultaneous [18F]FDG-PET/MRI examination (Biograph mMR, Siemens Healthcare)...
November 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27770953/superparamagnetic-iron-oxide-nanoparticles-conjugated-with-folic-acid-for-dual-target-specific-drug-delivery-and-mri-in-cancer-theranostics
#10
Yinping Huang, Kaili Mao, Baolin Zhang, Yingzheng Zhao
Monodispersed SPIONs (superparamagnetic iron oxide nanoparticles) co-coated with PEG and PEI polymers were prepared by an improved polyol method. To accomplish cancer-specific targeting properties, FA (folic acid) was then modified on the SPIONs via EDC/NHS method (FA-SPIONs). Doxorubicin (DOX) as an example anticancer drug was loaded within FA-SPIONs (DOX@FA-SPIONs), the DOX release rate of DOX@FA-SPIONs was much high in low pH PBS. The SPIONs, FA-SPIONs and DOX@FA-SPIONs with mean hydrodynamic diameters of 23, 40 and 67nm, respectively, performed excellent colloidal stability in PBS...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27762331/dce-mri-perfusion-and-permeability-parameters-as-predictors-of-tumor-response-to-ccrt-in-patients-with-locally-advanced-nsclc
#11
Xiuli Tao, Lvhua Wang, Zhouguang Hui, Li Liu, Feng Ye, Ying Song, Yu Tang, Yu Men, Tryphon Lambrou, Zihua Su, Xiao Xu, Han Ouyang, Ning Wu
In this prospective study, 36 patients with stage III non-small cell lung cancers (NSCLC), who underwent dynamic contrast-enhanced MRI (DCE-MRI) before concurrent chemo-radiotherapy (CCRT) were enrolled. Pharmacokinetic analysis was carried out after non-rigid motion registration. The perfusion parameters [including Blood Flow (BF), Blood Volume (BV), Mean Transit Time (MTT)] and permeability parameters [including endothelial transfer constant (K(trans)), reflux rate (Kep), fractional extravascular extracellular space volume (Ve), fractional plasma volume (Vp)] were calculated, and their relationship with tumor regression was evaluated...
October 20, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27743742/capecitabine-and-oxaliplatin-before-during-and-after-radiotherapy-for-high-risk-rectal-cancer
#12
Finn Ole Larsen, Alice Markussen, Benny V Jensen, Anne L Fromm, Kirsten K Vistisen, Vibeke K Parner, Dorte Linnemann, Rasmus H Hansen, Helle H Johannesen, Jakob V Schou
PURPOSE: To evaluate the effect of capecitabine and oxaliplatin before, during, and after radiotherapy for high-risk rectal cancer. PATIENTS AND METHODS: Patients with rectum cancer T4 or T3 involving the mesorectal fascia was included in a prospective phase 2 trial. Liver or lung metastases were accepted if the surgeons found them resectable. The patients received 6 weeks of capecitabine and oxaliplatin before chemoradiotherapy (CRT), continued capecitabine and oxaliplatin during radiotherapy, and received 4 weeks of capecitabine and oxaliplatin after CRT...
September 14, 2016: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/27738498/in-vivo-evaluation-of-riboflavin-receptor-targeted-fluorescent-uspio-in-mice-with-prostate-cancer-xenografts
#13
Jabadurai Jayapaul, Susanne Arns, Matt Bunker, Marek Weiler, Sandra Rutherford, Peter Comba, Fabian Kiessling
: Riboflavin (Rf) receptors bind and translocate Rf and its phosphorylated forms (e.g. flavin mononucleotide, FMN) into cells where they mediate various cellular metabolic pathways. Previously, we showed that FMN-coated ultrasmall superparamagnetic iron oxide (FLUSPIO) nanoparticles are suitable for labeling metabolically active cancer and endothelial cells in vitro. In this study, we focused on the in vivo application of FLUSPIO using prostate cancer xenografts. Size, charge, and chemical composition of FLUSPIO were evaluated...
2016: Nano Research
https://www.readbyqxmd.com/read/27725029/safety-of-intra-arterial-injection-with-tumor-activated-t-cells-to-the-rabbit-brain-evaluated-by-mri-and-spect-ct
#14
Johan Lundberg, Emma Jussing, Zhenjiang Liu, Qingda Meng, Martin Rao, Erik Samén, Rikard Grankvist, Peter Damberg, Ernest Dodoo, Markus Maeurer, Staffan Holmin
Glioblastoma (GBM) is the most common and most severe form of malignant gliomas. The prognosis is poor with current combinations of pharmaceutical-, radio- and surgical therapy. A continuous search for new treatments has therefore been ongoing for many years. Therapy with tumor-infiltrating lymphocytes (TIL) is a clinically promising strategy to treat various cancers, including GBM. An endovascular intra-arterial injection of TIL as a method of delivery may, instead of intravenous infusion, result in better retention of effector cells within the tumor...
October 7, 2016: Cell Transplantation
https://www.readbyqxmd.com/read/27693535/intracranial-activity-of-cabozantinib-in-met-exon-14-positive-nsclc-with-brain-metastases
#15
Samuel J Klempner, Ali Borghei, Behrooz Hakimian, Siraj M Ali, Sai-Hong Ignatius Ou
INTRODUCTION: A significant portion of NSCLCs with MET Proto-Oncogene, Receptor Tyrosine Kinase gene (MET) exon 14 skipping alterations are sensitive to small-molecule mesenchymal-epithelial transition tyrosine kinase inhibitors. However, the incidence and management of brain metastases in this molecular subset is unknown and represents an unmet clinical need. METHODS: Hybrid capture-based comprehensive genomic profiling identified a patient with a MET exon 14 skipping alteration, and serial magnetic resonance imaging was utilized to follow intracranial disease during crizotinib and subsequent cabozantinib therapy...
September 28, 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27693090/evaluation-of-lung-tumor-response-to-therapy-current-and-emerging-techniques
#16
E Coche
Lung tumor response to therapy may be evaluated in most instances by morphological criteria such as RECIST 1.1 on computed tomography (CT) or magnetic resonance imaging (MRI). However, those criteria are limited because they are based on tumoral dimensional changes and do not take into account other morphologic criteria such as density evaluation, functional or metabolic changes that may occur following conventional or targeted chemotherapy. New techniques such as dual-energy CT, PET-CT, MRI including diffusion-weighted MRI has to be considered into the new technical armamentarium for tumor response evaluation...
October 2016: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/27693089/contribution-of-magnetic-resonance-imaging-in-lung-cancer-imaging
#17
A Khalil, M Majlath, V Gounant, A Hess, J P Laissy, M P Debray
Lung cancer is the leading cause of cancer death worldwide. Prognosis and treatment outcomes are known to be related to the disease stage at the time of diagnosis. Therefore, an accurate assessment of the extent of disease is critical to determine the most appropriate therapy. Currently available imaging modalities for diagnosis and follow-up consist of morphological and functional imaging. Morphological investigations are mainly performed with CT-scan and in some cases with MRI. In this review, we describe the contribution of MRI in lung cancer staging focusing on solid pulmonary nodule characterization and TNM staging assessment using chest and whole-body MRI examinations, detailing in each chapter current recommendations and future developments...
October 2016: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/27686542/-using-3-0-t-mr-to-dynamically-observe-ablated-lung-tumors-after-percutaneous-cryotherapy-therapy
#18
J Li, J R Qu, H K Zhang, J C Xiao, L N Jiang, Y Zhao, H L Li
Objective: To initially explore MRI features and its changing trends including of lung tumors after Argon-Helium cryoablation therapy, and enhance the recognition of MR findings of lung tumors postcryoablation. Methods: Twenty-three cases of patients with twenty six nodules of pulmonary malignance who received Argon-Helium cryoablation therapy in Henan Cancer Hospital from July 2014 to January 2016 were enrolled.All patients underwent unenhanced and dynamic contrast-enhanced MRI scans at pre-and 1-day, 1-week, 1-, 3-, 6-, 12-month postcryoablation...
September 20, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27665148/screening-for-lung-cancer-does-mri-have-a-role
#19
Juergen Biederer, Yoshiharu Ohno, Hiroto Hatabu, Mark L Schiebler, Edwin J R van Beek, Jens Vogel-Claussen, Hans-Ulrich Kauczor
While the inauguration of national low dose computed tomographic (LDCT) lung cancer screening programs has started in the USA, other countries remain undecided, awaiting the results of ongoing trials. The continuous technical development achieved by stronger gradients, parallel imaging and shorter echo time has made lung magnetic resonance imaging (MRI) an interesting alternative to CT. For the detection of solid lesions with lung MRI, experimental and clinical studies have shown a threshold size of 3-4mm for nodules, with detection rates of 60-90% for lesions of 5-8mm and close to 100% for lesions of 8mm or larger...
September 16, 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27661665/pancreatic-resection-for-renal-cell-carcinoma-metastasis-an-exceptionally-rare-coexistence
#20
Stergios Boussios, Ioannis Zerdes, Ourania Batsi, Vasilios P Papakostas, Esmeralda Seraj, George Pentheroudakis, George K Glantzounis
INTRODUCTION: Pancreatic metastases are uncommon and only found in a minority of patients with widespread metastatic disease at autopsy. The most common primary cancer site resulting in pancreatic metastases is the kidney, followed by colorectal cancer, melanoma, breast cancer, lung carcinoma and sarcoma. PRESENTATION OF CASE: Herein, we report a 63-year-old male patient who presented -3.5 years after radical nephrectomy performed for renal cell carcinoma (RCC)-with a well-defined lobular, round mass at the body of the pancreas demonstrated by abdominal Magnetic Resonance Imaging (MRI)...
2016: International Journal of Surgery Case Reports
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