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Pulmonary functional MRI

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https://www.readbyqxmd.com/read/28426728/pulmonary-vascular-volume-impaired-left-ventricular-filling-and-dyspnea-the-mesa-lung-study
#1
Carrie P Aaron, Eric A Hoffman, Joao A C Lima, Steven M Kawut, Alain G Bertoni, Jens Vogel-Claussen, Mohammadali Habibi, Katja Hueper, David R Jacobs, Ravi Kalhan, Erin D Michos, Wendy S Post, Martin R Prince, Benjamin M Smith, Bharath Ambale-Venkatesh, Chia-Ying Liu, Filip Zemrak, Karol E Watson, Matthew Budoff, David A Bluemke, R Graham Barr
BACKGROUND: Evaluation of impaired left ventricular (LV) filling has focused on intrinsic causes of LV dysfunction; however, pulmonary vascular changes may contribute to reduced LV filling and dyspnea. We hypothesized that lower total pulmonary vascular volume (TPVV) on computed tomography (CT) would be associated with dyspnea and decrements in LV end-diastolic volume, particularly among ever-smokers. METHODS: The Multi-Ethnic Study of Atherosclerosis recruited adults without clinical cardiovascular disease in 2000-02...
2017: PloS One
https://www.readbyqxmd.com/read/28424613/the-relationship-between-cerebral-small-vessel-disease-hippocampal-volume-and-cognitive-functioning-in-patients-with-copd-an-mri-study
#2
Fiona A H M Cleutjens, Rudolf W H M Ponds, Martijn A Spruit, Saartje Burgmans, Heidi I L Jacobs, Ed H B M Gronenschild, Julie Staals, Frits M E Franssen, Jeanette B Dijkstra, Lowie E G W Vanfleteren, Paul A Hofman, Emiel F M Wouters, Daisy J A Janssen
The neural correlates of cognitive impairment in chronic obstructive pulmonary disease (COPD) are not yet understood. Structural brain abnormalities could possibly be associated with the presence of cognitive impairment through cigarette smoke, inflammation, vascular disease, or hypoxemia in these patients. This study aimed to investigate whether macrostructural brain magnetic resonance imaging (MRI) features of cerebral small vessel disease (SVD) and hippocampal volume (HCV) are related to cognitive performance in patients with COPD...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28414679/misses-opportunity-tof-diagnoses-in-4th-decade-of-life
#3
O Baniahmad, T Jarreau, A Johnson
CASE: A 40 year old woman with a history of HIV, congestive heart failure secondary to an unknown congenital heart defect, and hypertension presented to our emergency department with worsening edema. On room air, oxygen saturation was 55 percent . On 5L of oxygen via nasal cannula, oxygen saturation was 88 percent . Physical examination was notable for central cyanosis, facial and lid edema, a II/VI holosystolic murmur across right chest radiating to entire right back hemithorax, decreased breath sounds at bases with pulmonary crackles, clubbing of fingers and edema of bilateral lower extremities...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28409073/facial-paralysis-and-hearing-loss-a-rare-manifestation-of-prostate-cancer-metastases
#4
Uroosa Ibrahim, Amina Saqib, Farhan Mohammad, Muhammad R Raza, Nikhil Nalluri, Frank Forte
Dural prostate metastases (DPM) are a rare manifestation of metastatic prostate cancer seen in approximately one to six percent of cases. Presenting symptoms may include signs of elevated intracranial pressure, headache, altered mental status, or cranial nerve palsies. Hearing loss, sensory changes, dysarthria, and dysphagia are rare symptoms in DPM that were present in our patient. We present a case of a 58-year-old male with a known diagnosis of adenocarcinoma of the prostate presenting with symptoms of acute exacerbation of chronic obstructive pulmonary disease (COPD), sub-acute right-sided hearing loss, and right-sided facial paralysis...
March 3, 2017: Curēus
https://www.readbyqxmd.com/read/28403885/lung-structure-and-function-similarities-between-primary-ciliary-dyskinesia-and-mild-cystic-fibrosis-a-pilot-study
#5
Marco Maglione, Silvia Montella, Carmine Mollica, Vincenzo Carnovale, Paola Iacotucci, Fabiola De Gregorio, Antonella Tosco, Mariarosaria Cervasio, Valeria Raia, Francesca Santamaria
BACKGROUND: Primary ciliary dyskinesia (PCD) and cystic fibrosis (CF) are increasingly compared. There are no chest magnetic resonance imaging (MRI) comparative studies of PCD and CF. We assessed clinical, functional, microbiological and MRI findings in PCD and mild CF patients in order to evaluate different expression of lung disease. METHODS: Twenty PCD (15.1 years) and 20 CF subjects with mild respiratory impairment (16 years, 70% with pancreatic insufficiency) underwent MRI, spirometry, and sputum cultures when clinically stable...
April 12, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28398019/epidemiology-anatomy-pathophysiology-and-clinical-evaluation-of-functional-tricuspid-regurgitation
#6
Yee-Ping Sun, Patrick T O' Gara
Tricuspid regurgitation (TR) is commonly encountered in the management of patients with a variety of cardiovascular diseases. Primary TR is the result of structural abnormalities of the valve or chordal attachments whereas functional TR results from alterations in right ventricular (RV) or right atrial (RA) size, shape or function. The vast majority of TR cases seen in practice are functional in nature and usually results from left-sided heart disease (e.g., mitral valve disease, left ventricular (LV) systolic dysfunction) and/or pulmonary vascular disease, though it also manifests in the presence of isolated chronic atrial fibrillation (AF)...
April 10, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28384123/magnetic-resonance-imaging-with-hyperpolarized-agents-methods-and-applications
#7
Erin Adamson, Kai Ludwig, David Mummy, Sean B Fain
In the past decade, hyperpolarized (HP) contrast agents have been under active development for MRI applications to address the twin challenges of functional and quantitative imaging. Both HP helium (<sup>3</sup>He) and xenon (<sup>129</sup>Xe) gases have reached the stage where they are under study in clinical research. HP <sup>129</sup>Xe, in particular, is poised for larger scale clinical research to investigate asthma, chronic obstructive pulmonary disease, and fibrotic lung diseases...
April 6, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28291826/endothelial-progenitor-cells-in-chronic-obstructive-pulmonary-disease-and-emphysema
#8
Margaret F Doyle, Russell P Tracy, Megha A Parikh, Eric A Hoffman, Daichi Shimbo, John H M Austin, Benjamin M Smith, Katja Hueper, Jens Vogel-Claussen, Joao Lima, Antoinette Gomes, Karol Watson, Steven Kawut, R Graham Barr
Endothelial injury is implicated in the pathogenesis of COPD and emphysema; however the role of endothelial progenitor cells (EPCs), a marker of endothelial cell repair, and circulating endothelial cells (CECs), a marker of endothelial cell injury, in COPD and its subphenotypes is unresolved. We hypothesized that endothelial progenitor cell populations would be decreased in COPD and emphysema and that circulating endothelial cells would be increased. Associations with other subphenotypes were examined. The Multi-Ethnic Study of Atherosclerosis COPD Study recruited smokers with COPD and controls age 50-79 years without clinical cardiovascular disease...
2017: PloS One
https://www.readbyqxmd.com/read/28280107/ventilation-heterogeneity-measured-by-multiple-breath-inert-gas-testing-is-not-affected-by-inspired-oxygen-concentration-in-healthy-humans
#9
Susan Roberta Hopkins, Ann R Elliott, Gordon Kim Prisk, Chantal Darquenne
Multiple breath washout (MBW) and oxygen-enhanced MRI techniques use acute exposure to 100% oxygen to measure ventilation heterogeneity. Implicit is the assumption that breathing 100% oxygen does not induce changes in ventilation heterogeneity, however, this is untested. We hypothesized that ventilation heterogeneity decreases with increasing inspired oxygen concentration in healthy subjects. We performed MBW in 8 healthy subjects (4 female, 4 male, Age=43±15y) with normal pulmonary function (FEV1=98±6% predicted) using 10% Argon as a tracer gas and oxygen concentrations of 12...
March 9, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28277913/observed-to-expected-mri-fetal-lung-volume-can-predict-long-term-lung-morbidity-in-infants-with-congenital-diaphragmatic-hernia
#10
Hiroyuki Tsuda, Tomomi Kotani, Mayo Miura, Yumiko Ito, Shima Hirako, Tomoko Nakano, Kenji Imai, Fumitaka Kikkawa
OBJECTIVE: Congenital diaphragmatic hernia (CDH) causes pulmonary hypoplasia and pulmonary hypertension, which are associated with long-term respiratory problems in infants. The aim of this study was to establish a marker for predicting lung function at 1 year of age in infants with CDH. MATERIAL AND METHODS: Infants with isolated CDH who were delivered after 35 weeks of gestation from April 2008 to June 2016 at Nagoya University Hospital were registered. Regarding alive infants with CDH, only those who underwent follow-up for at least 1 year were registered...
February 24, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28214964/speckle-tracking-in-alcapa-patients-after-surgical-repair-as-predictor-of-residual-coronary-disease
#11
Biagio Castaldi, Vladimiro Vida, Elena Reffo, Massimo Padalino, Queenette Daniels, Giovanni Stellin, Ornella Milanesi
Surgical re-implantation of the left coronary artery (LCA) is the treatment of choice in anomalous origin of left coronary artery from pulmonary artery (ALCAPA). Despite normalization of left ventricular function after surgery, residual coronary lesions or myocardial fibrosis may be found. The aim of this study was to detect regional left ventricular dysfunction predictive of coronary lesions or residual myocardial fibrosis using speckle tracking. We enrolled ten patients treated with surgical re-implantation of LCA for ALCAPA...
February 18, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28207845/reproducibility-and-comparison-of-oxygen-enhanced-t1-quantification-in-copd-and-asthma-patients
#12
Simon M F Triphan, Bertram J Jobst, Angela Anjorin, Oliver Sedlaczek, Ursula Wolf, Maxim Terekhov, Christian Hoffmann, Sebastian Ley, Christoph Düber, Jürgen Biederer, Hans-Ulrich Kauczor, Peter M Jakob, Mark O Wielpütz
T1 maps have been shown to yield useful diagnostic information on lung function in patients with chronic obstructive pulmonary disease (COPD) and asthma, both for native T1 and ΔT1, the relative reduction while breathing pure oxygen. As parameter quantification is particularly interesting for longitudinal studies, the purpose of this work was both to examine the reproducibility of lung T1 mapping and to compare T1 found in COPD and asthma patients using IRSnapShotFLASH embedded in a full MRI protocol. 12 asthma and 12 COPD patients (site 1) and further 15 COPD patients (site 2) were examined on two consecutive days...
2017: PloS One
https://www.readbyqxmd.com/read/28206676/thoracic-ct-mri-co-registration-for-regional-pulmonary-structure-function-measurements-of-obstructive-lung-disease
#13
Fumin Guo, Sarah Svenningsen, Miranda Kirby, Dante P I Capaldi, Khadija Sheikh, Aaron Fenster, Grace Parraga
PURPOSE: Recent pulmonary imaging research has revealed that in patients with chronic obstructive pulmonary disease (COPD) and asthma, structural and functional abnormalities are spatially heterogeneous. This novel information may help optimize treatment in individual patients, monitor interventional efficacy and develop new treatments. Moreover, by automating the measurement of regional biomarkers for the 19 different anatomical lung segments, there is an opportunity to embed imaging biomarkers into clinically-acceptable clinical workflows and improve lung disease clinical care...
February 16, 2017: Medical Physics
https://www.readbyqxmd.com/read/28167746/randomised-controlled-trial-examining-the-effect-of-an-outpatient-exercise-training-programme-on-haemodynamics-and-cardiac-mr-parameters-of-right-ventricular-function-in-patients-with-pulmonary-arterial-hypertension-the-expah-study-protocol
#14
Karen S W Chia, Steven G Faux, Peter K K Wong, Cameron Holloway, Hassan Assareh, Craig S McLachlan, Eugene Kotlyar
INTRODUCTION: Pulmonary hypertension (PH) is a potentially life-threatening condition characterised by elevated pulmonary artery pressure. Early stage PH patients are often asymptomatic. Disease progression is associated with impairment of right ventricular function and progressive dyspnoea. Current guidelines recommend exercise training (grade IIa, level B). However, many questions remain regarding the mechanisms of improvement, intensity of supervision and optimal frequency, duration and intensity of exercise...
February 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28159433/-mri-of-the-pulmonary-parenchyma-towards-clinical-applicability
#15
REVIEW
G Dournes, J Macey, E Blanchard, P Berger, F Laurent
Lung parenchyma has long been considered out of the scope of magnetic resonance imaging (MRI) clinical applicability. However, technological advances have emerged to soluce the technical difficulties and thus, applications in clinical practice have become realistic. Nevertheless, various approaches have been proposed and there is a need to synthetize the most recent literature data in order to envision a rationale to build lung MR protocols for clinical use. In addition, these technological innovations may modify the usual paradigms of lung MRI, which are still not consensual...
February 2017: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/28120553/what-makes-a-good-pediatric-transplant-lung-insights-from-in-vivo-lung-morphometry-with-hyperpolarized-3-he-magnetic-resonance-imaging
#16
Emily F Fishman, James D Quirk, Stuart C Sweet, Jason C Woods, David S Gierada, Mark S Conradi, Marilyn J Siegel, Dmitriy A Yablonskiy
Obtaining information on transplanted lung microstructure is an important part of the current care for monitoring transplant recipients. However, until now this information was only available from invasive lung biopsy. The objective of this study was to evaluate the use of an innovative non-invasive technique, in vivo lung morphometry with hyperpolarized ³He MRI-to characterize lung microstructure in the pediatric lung transplant population. This technique yields quantitative measurements of acinar airways' (alveolar ducts and sacs) parameters, such as acinar airway radii and alveolar depth...
May 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28051771/proarrhythmic-remodelling-of-the-right-ventricle-in-a-porcine-model-of-repaired-tetralogy-of-fallot
#17
David Benoist, Virginie Dubes, François Roubertie, Stephen H Gilbert, Sabine Charron, Marion Constantin, Delphine Elbes, Delphine Vieillot, Bruno Quesson, Hubert Cochet, Michel Haïssaguerre, Caroline Rooryck, Pierre Bordachar, Jean-Benoit Thambo, Olivier Bernus
OBJECTIVE: The growing adult population with surgically corrected tetralogy of Fallot (TOF) is at risk of arrhythmias and sudden cardiac death. We sought to investigate the contribution of right ventricular (RV) structural and electrophysiological remodelling to arrhythmia generation in a preclinical animal model of repaired TOF (rTOF). METHODS AND RESULTS: Pigs mimicking rTOF underwent cardiac MRI functional characterisation and presented with pulmonary regurgitation, RV hypertrophy, dilatation and dysfunction compared with Sham-operated animals (Sham)...
October 8, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28048615/tu-h-202-04-the-vampire-challenge-preliminary-results-from-a-multi-institutional-study-of-ct-ventilation-image-accuracy
#18
J Kipritidis
CT ventilation imaging is an exciting functional imaging modality that combines four-dimensional computed tomography (4DCT) and deformable image registration (DIR) to provide exquisite ventilation maps of the lung. CT ventilation imaging can be used for: (1) Functional avoidance in thoracic radiation therapy, (2) Imaging longitudinal changes in regional lung function for treatment assessment and adaptation, (3) Image-assisted diagnosis of non-oncologic respiratory diseases. CT ventilation imaging uses CT, a predominantly anatomic imaging modality, and through imaging processing creates functional images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048557/tu-h-202-00-ct-ventilation-imaging-the-new-clinical-reality-of-functional-avoidance-and-response-assessment-in-lung-cancer-radiation-therapy
#19
Paul Keall
CT ventilation imaging is an exciting functional imaging modality that combines four-dimensional computed tomography (4DCT) and deformable image registration (DIR) to provide exquisite ventilation maps of the lung. CT ventilation imaging can be used for: (1) Functional avoidance in thoracic radiation therapy, (2) Imaging longitudinal changes in regional lung function for treatment assessment and adaptation, (3) Image-assisted diagnosis of non-oncologic respiratory diseases. CT ventilation imaging uses CT, a predominantly anatomic imaging modality, and through imaging processing creates functional images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048395/we-fg-206-07-assessing-the-lung-function-of-patients-with-non-small-cell-lung-cancer-using-hyperpolarized-xenon-129-dissolved-phase-mri
#20
K Qing, J Mugler, Q Chen
PURPOSE: Hyperpolarized xenon-129 dissolved-phase MRI is the first imaging technique that allows 3-dimensional regional mapping of ventilation and gas uptake by tissue and blood the in human lung. Multiple outcome measures can be produced from this method. Existing studies in subjects with major lung diseases compared to healthy controls demonstrated high sensitivities of this method to pulmonary physiological factors including ventilation, alveolar tissue density, surface-to-volume ratio, pulmonary perfusion and gas-blood barrier thickness...
June 2016: Medical Physics
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