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https://www.readbyqxmd.com/read/28074677/the-effective-tool-for-self-assessment-of-adherence-to-treatment-in-patients-with-benign-prostatic-obstruction-and-overactive-bladder-symptoms
#1
Kirill Kosilov, Sergey Loparev, Irina Kuzina, Olga Shakirova, Natalya Zhuravskaya, Alexandra Lobodenko
PURPOSE: Study of validity of the Medication Adherence Self-Report Inventory (MASRI) for use in clinical practice to treat patients with benign prostatic obstruction (BPO) accompanied with overactive bladder (OAB) symptoms. METHODS: During 12 weeks of the randomized study, 452 patients with BPO and OAB symptoms (mean age of 61.3 (12.7)) were studied for adherence to the treatment with Tamsulosin, Solifenacin and Trospium using the MASRI. External monitoring instruments included the Brief Medication Questionnaire (BMQ) and the visual remaining pill count...
January 11, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28068846/impact-of-tamsulosin-and-nifedipine-on-contractility-of-pregnant-rat-ureters-in-vitro
#2
Lisette Haddad, Stéphanie Corriveau, Eric Rousseau, Simon Blouin, Jean-Charles Pasquier, Yves Ponsot, Marie-Ève Roy-Lacroix
OBJECTIVES: To evaluate the in vitro effect of tamsulosin and nifedipine on the contractility of pregnant rat ureters and to perform quantitative analysis of the pharmacological effects. Medical expulsive therapy (MET) is commonly used to treat urolithiasis. However, this treatment is seldom used in pregnant women since no studies support this practice. METHODS: This was an in vitro study on animal tissue derived from pregnant Sprague-Dawley rats. A total of 124 ureteral segments were mounted in an organ bath system and contractile response to methacholine (MCh) was assessed...
January 9, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28029383/pilot-results-from-a-randomized-trial-in-men-comparing-alpha-adrenergic-antagonist-versus-behavior-and-exercise-for-nocturia-and-sleep
#3
Theodore M Johnson, Camille P Vaughan, Patricia S Goode, Donald L Bliwise, Alayne D Markland, Carrie Huisingh, David T Redden, Gerald McGwin, Rina Eisenstein, Joseph G Ouslander, Muta Issa, Kathryn L Burgio
PURPOSE: Nocturia and sleep problems are common in older adults. We developed and tested a novel intervention, multicomponent behavioral treatment and exercise therapy (M-BET), that may reduce nocturia and improve sleep in men. We compared reductions in nocturia and improvement in sleep in men with M-BET versus an active drug comparator (α-blocker) used alone or in combination (M-BET + α-blocker) METHODS: This randomized, controlled trial was conducted in the ambulatory setting in 2 US Department of Veterans Affairs medical centers in men at least 40 years of age with nocturia (defined as ≥2 nightly episodes)...
October 28, 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/28007106/one-day-postoperative-intraocular-pressure-spikes-after-phacoemulsification-cataract-surgery-in-patients-taking-tamsulosin
#4
Levi N Bonnell, Jeffrey R SooHoo, Leonard K Seibold, Anne M Lynch, Brandie D Wagner, Richard S Davidson, Michael J Taravella
PURPOSE: To evaluate the relationship between 1-day postoperative intraocular pressure (IOP) after phacoemulsification cataract surgery and tamsulosin use. SETTING: University of Colorado Health Eye Center, Aurora, Colorado, USA. DESIGN: Retrospective cohort study. METHODS: Registry data from men who had cataract surgery were used. Patients taking tamsulosin at the time of surgery were included as cases, while patients with no history of tamsulosin use were used as controls...
December 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27981373/-combined-treatment-of-bps-with-tamsulosin-and-finasteride-literature-review-and-prescription-data
#5
K Höfner, S Ulrich, R Berges
Combined therapy of benign prostatic syndrome (BPS) with α1-blockers and 5α-reductase (5AR)-inhibitors is recommended according to two leading studies on doxazosin/finasteride and tamsulosin/dutasteride for all 10 in Germany possible combinations (five α1-blockers and two 5AR inhibitors). Because tamsulosin and finasteride predominate in the treatment of BPS in Germany, the role of the combination tamsulosin/finasteride and its scientific basis from clinical studies has been investigated. A pharmacoepidemiological extrapolation from receipts of pharmacy data centres showed a strong increase of the combination tamsulosin/finasteride since 2003...
December 15, 2016: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/27979545/re-finasteride-not-tamsulosin-increases-severity-of-erectile-dysfunction-and-decreases-testosterone-levels-in-men-with-benign-prostatic-hyperplasia
#6
https://www.readbyqxmd.com/read/27971355/cost-effectiveness-of-combination-therapy-with-dutasteride-tamsulosin-an-analysis-based-on-conduct-trial
#7
L A Vallejo-Aparicio, B Miñana López, F J Brenes, J M Molero, A Fernández-Pro, A Huerta, J M Cozar
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27958220/efficacy-and-safety-of-medium-to-long-term-use-of-tolterodine-extended-release-with-or-without-tamsulosin-in-patients-with-benign-prostate-hyperplasia-and-larger-prostate-size-a-double-blind-placebo-controlled-randomized-clinical-trial
#8
Jian-Liang Cai, Zhe Zhou, Yan Yang, Yi-Fu Yan, Shuo Jing, Yan-Qun Na
BACKGROUND: The medium-to-long-term use of antimuscarinics alone or in combination with an α-blocker in men with an enlarged prostate is still controversial. This double-blind, placebo-controlled, randomized clinical trial aimed to investigate the efficacy and safety of medium-to-long-term use of tolterodine extended release (ER) with or without tamsulosin in patients with benign prostate hyperplasia (BPH) and larger prostate size. METHODS: Totally, 152 patients (age ≥50 years) with BPH, International Prostate Symptom Score (IPSS) ≥12, quality-of-life (QoL) score ≥3, and total prostate volume ≥25 ml were enrolled in this study...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27928815/comparing-monotherapy-with-tadalafil-or-tamsulosin-and-their-combination-therapy-in-men-with-benign-prostatic-hyperplasia-a-randomized-clinical-trial
#9
Hossein Karami, Amin Hassanzadeh-Hadad, Morteza Fallah-Karkan
PURPOSE: To compare monotherapy with tadalafil or tamsulosin and their combination therapy in men with benignprostatic hyperplasia and erectile dysfunction by comparing IPSS score, prostate volume and Qmax and someother outcomes. MATERIALS AND METHODS: This randomized, single-blind, paralleled group clinical trial was done in 2013 on patientswho had referred to our hospital in Tehran. All patients with lower urinary tract symptoms, benign prostatichyperplasia and any grade of erectile dysfunction were recruited...
8, 2016: Urology Journal
https://www.readbyqxmd.com/read/27928809/efficacy-of-medical-expulsive-therapy-in-renal-calculi-less-than-or-equal-to-5-millimetres-in-size
#10
Sudarshan Daga, Vinayak G Wagaskar, Harshawardhan Tanwar, Umesh Shelke, Bhushan Patil, Sujata Patwardhan
PURPOSE: Natural history and modality of treatment for asymptomatic renal calculi less than or equal to 5 millimetres in size is still unknown. Many options are available ranging from medical expulsive therapy to minimally invasive surgery. Till date no study has focussed on this very common but asymptomatic issue. Hence, this study is undertaken to evaluate efficacy of medical expulsive therapy in renal calculi less than or equal to 5mm in size. MATERIALS AND METHODS: A prospective, parallel group, randomized study was carried out from 1st June 2014 to 31st May 2015, with total of 100 patients, 50 patients in each group...
8, 2016: Urology Journal
https://www.readbyqxmd.com/read/27915481/effects-of-combination-treatment-of-alpha-1-adrenergic-receptor-antagonists-on-voiding-dysfunction-study-on-target-organs-in-overactive-bladder-rats
#11
Il Gyu Ko, Bo Min Moon, Sung Eun Kim, Jun Jang Jin, Lakkyong Hwang, Eun Sang Ji, Chang Ju Kim, Tai Hyung Kim, Hyun Hee Choi, Kyung Jin Chung
PURPOSE: Overactive bladder (OAB) causes urinary urgency, usually accompanied by frequency and nocturia. Alpha 1-adrenergic receptor (α1-AR) antagonists are known to improve lower urinary tract symptoms associated with OAB. The α1-AR antagonists constitute a variety of drugs according to the receptor subtype affinity. This study investigated the efficacy of tamsulosin, naftopidil, and a combination of the two on OAB rats. METHODS: The OAB rat model was induced by an intraperitoneal injection of cyclophosphamide for 14 days...
November 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27896711/using-eq-5d-3l-and-oab-5d-to-assess-changes-in-the-health-related-quality-of-life-of-men-with-lower-urinary-tract-symptoms-associated-with-benign-prostatic-hyperplasia
#12
Zalmai Hakimi, Mike Herdman, Marco Pavesi, Nancy Devlin, Jameel Nazir, Chris Hoyle, Isaac A O Odeyemi
OBJECTIVES: To assess changes in the health status of men with lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH) using the EQ-5D-3L and OAB-5D instruments and to evaluate the sensitivity of the instruments. METHODS: Data were available from a large randomised phase III trial of men with moderate-to-severe storage and voiding LUTS/BPH (NEPTUNE). Men received a fixed-dose combination of solifenacin 6 mg plus oral controlled absorption system (OCAS™) formulation of tamsulosin (TOCAS, 0...
November 28, 2016: Quality of Life Research
https://www.readbyqxmd.com/read/27890522/design-and-challenges-of-a-randomized-clinical-trial-of-medical-expulsive-therapy-tamsulosin-for-urolithiasis-in-the-emergency-department
#13
Pamela K Burrows, Judd E Hollander, Allan B Wolfson, Michael C Kurz, Lorna Richards, Sara DiFiore, Phillip Watts, Nivedita Patkar, Jeremy Brown, Stephen Jackman, Ziya Kirkali, John W Kusek, Chloe Michel, Andrew C Meltzer
Urolithiasis or urinary stone disease has been estimated to affect about 1 in 11 Americans. Patients with urinary stone disease commonly present to the emergency department for management of their acute pain. In addition to providing analgesia, administration of drug (medical expulsive therapy) is often prescribed to assist passage of the urinary stone. In this methodology paper, we describe the design of a prospective, multi-center, randomized, double-blind placebo controlled clinical trial of the alpha-adrenergic blocker, tamsulosin, to evaluate its effectiveness as medical expulsive therapy...
January 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27871076/semi-rigid-ureteroscopy-for-proximal-ureteral-stones-does-adjunctive-tamsulosin-therapy-increase-the-chance-of-success
#14
Abul-Fotouh Ahmed, Aref Maarouf, Essam Shalaby, Saad Alshahrani, Mohamed El-Feky, Sabri Khaled, Abdullah Daoud, Ahmed Soliman, Esam Desoky, Hisham El-Helaly
OBJECTIVES: To assess the efficacy of adjunctive tamsulosin therapy in improving the success rate of laser-assisted semi-rigid ureteroscopy (URS) for removing proximal ureteral stones. PATIENTS AND METHODS: This prospective study included 165 patients with proximal ureteral stones ≥10 mm. The patients were randomly assigned to a tamsulosin group (Group I, n = 81) receiving tamsulosin 0.4 mg daily for 1 week pre-URS and a control group (Group II, n = 84) without tamsulosin therapy...
November 22, 2016: Urologia Internationalis
https://www.readbyqxmd.com/read/27846839/combination-therapy-only-shows-short-term-superiority-over-monotherapy-on-ureteral-stent-related-symptoms-outcome-from-a-randomized-controlled-trial
#15
Qinyu Liu, Banghua Liao, Ruochen Zhang, Tao Jin, Liang Zhou, Deyi Luo, Jiaming Liu, Hong Li, Kunjie Wang
BACKGROUND: Controversy remains on the superiority of combination therapy over monotherapy on ureteral stent-related symptoms (SRSs). We tend to explore if there is a necessity of combination therapy. METHODS: One hundred cases of unilateral upper urinary tract calculi with stent insertion (pre and post flexible ureteroscopy) were randomized into 4 groups, given non-treatment, solifenacin, tamsulosin or combination respectively. Eight times of follow-ups were given after each insertion...
November 15, 2016: BMC Urology
https://www.readbyqxmd.com/read/27836488/characterization-the-affinity-of-%C3%AE-1a-adrenoreceptor-by-cell-membrane-chromatography-with-frontal-analysis-and-stoichiometric-displacement-model
#16
Fen Wei, Sicen Wang, Nan Lv, Yusi Bu, Xiaoyu Xie
As a bionic chromatographic method, cell membrane chromatography (CMC) has been used widely in screening active components in traditional Chinese medicine. Nevertheless, few studies have characterized the affinity between drug and receptor by CMC model. In this study, the alpha 1 adrenoreceptor (α1A AR) high expression CMC method, combined with frontal analysis and stoichiometric displacement model respectively, was established for characterizing the affinity of seven alkaloids binding to the α1A AR. The results indicate that the seven alkaloids have similar interaction strengths with tamsulosin hydrochloride (α1A AR antagonist) between them and α1A AR...
January 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27812496/reversible-exacerbation-of-obstructive-sleep-apnea-by-%C3%AE-1-adrenergic-blockade-with-tamsulosin-a-case-report
#17
Mark Moran
: Obstructive sleep apnea (OSA) is characterized by repeated involuntary closure of the pharyngeal airspace during sleep. Normal activity of the genioglossus (GG) muscle is important in maintaining airway patency, and inhibition of GG activity can contribute to airway closure. Neurons in the hypoglossal motor nucleus (HMN) regulate GG activity. Adrenergic tone is an important regulator of HMN neuronal excitability. In laboratory models α1-adrenergic antagonists inhibit HMN neurons and GG activity, suggesting that α1-adrenergic antagonism might adversely affect patients with OSA...
2016: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/27809592/tamsulosin-solifenacin-and-their-combination-for-the-treatment-of-stent-related-symptoms-a-randomized-controlled-study
#18
Athanasios E Dellis, Athanasios G Papatsoris, Francis X Keeley, Aristotelis Bamias, Charalambos Deliveliotis, Andreas A Skolarikos
PURPOSE: To properly use the Ureteric Symptom Score Questionnaire (USSQ) to evaluate, in a randomized control study, the effect of tamsulosin, solifenacin, and their combination in improving symptoms and quality of life in patients with indwelling ureteral stents. MATERIALS AND METHODS: After institutional review board approval, 260 patients with a ureteral stent were randomly assigned to receive tamsulosin 0.4 mg, solifenacin 5 mg, or placebo and further randomized to receive their combination...
January 2017: Journal of Endourology
https://www.readbyqxmd.com/read/27774128/discovery-of-ono-7300243-from-a-novel-class-of-lysophosphatidic-acid-receptor-1-antagonists-from-hit-to-lead
#19
Masahiko Terakado, Hidehiro Suzuki, Kazuya Hashimura, Motoyuki Tanaka, Hideyuki Ueda, Hiroshi Kohno, Taku Fujimoto, Hiroshi Saga, Shinji Nakade, Hiromu Habashita, Yoshikazu Takaoka, Takuya Seko
Lysophosphatidic acid (LPA) evokes various physiological responses through a series of G protein-coupled receptors known as LPA1-6. A high throughput screen against LPA1 gave compound 7a as a hit. The subsequent optimization of 7a led to ONO-7300243 (17a) as a novel, potent LPA1 antagonist, which showed good efficacy in vivo. The oral dosing of 17a at 30 mg/kg led to reduced intraurethral pressure in rats. Notably, this compound was equal in potency to the α1 adrenoceptor antagonist tamsulosin, which is used in clinical practice to treat dysuria with benign prostatic hyperplasia (BPH)...
October 13, 2016: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27761703/intraoperative-floppy-iris-syndrome-and-its-association-with-various-concurrent-medications-bulbus-length-patient-age-and-gender
#20
Michael Wahl, Saskia M Tipotsch-Maca, Pia V Vecsei-Marlovits
PURPOSE: To evaluate the association between intraoperative floppy iris syndrome (IFIS) and concurrent medications containing selective alpha1A receptor antagonists as well as nonselective alpha1-adrenergic receptor antagonists, bulbus length, patient age and gender. METHODS: We performed a prospective data acquisition of IFIS occurrence and grading, and retrospective evaluation of concurrent medications, bulbus length, patient age and gender of all patients undergoing cataract surgery over a 6-month period...
January 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
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