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https://www.readbyqxmd.com/read/29341324/beta-testing-the-potential-link-between-the-alpha-antagonist-tamsulosin-and-dementia
#1
Sudeep S Gill, Anthony D Bai
No abstract text is available yet for this article.
January 17, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29334287/efficacy-and-safety-of-alpha-blockers-in-medical-expulsive-therapy-for-ureteral-stones-a-mixed-treatment-network-meta-analysis-and-trial-sequential-analysis-of-randomized-controlled-clinical-trials
#2
Kannan Sridharan, Gowri Sivaramakrishnan
Alpha blockers (AB) are the main group of drugs used for medical expulsive therapy (MET) in patients with ureteral stones. However, there is no consensus on the relative efficacy and safety of individual AB in MET. Areas covered: The present work is a network meta-analysis of randomized controlled trials comparing AB with either placebo or standard of care in patients with ureteral stones. Electronic databases of Medline, Cochrane CENTRAL and Google Scholar were searched for eligible clinical studies. Inverse variance heterogeneity model was used for mixed treatment comparisons...
January 15, 2018: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/29321112/the-evaluation-and-management-of-urolithiasis-in-the-emergency-department-a-review-of-the-literature
#3
REVIEW
Michael Gottlieb, Brit Long, Alex Koyfman
BACKGROUND: Urolithiasis is a common condition in the U.S. Patients frequently present to the emergency department (ED) for care, including analgesia and treatments to facilitate stone passage. OBJECTIVE: With the new evidence concerning the evaluation and treatment of urolithiasis, this review summarizes current literature regarding the ED management of urolithiasis. DISCUSSION: Urolithiasis occurs primarily through supersaturation of urine and commonly presents with flank pain, hematuria, and nausea/vomiting...
January 5, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29316005/tamsulosin-and-the-risk-of-dementia-in-older-men-with-benign-prostatic-hyperplasia
#4
Yinghui Duan, James J Grady, Peter C Albertsen, Z Helen Wu
PURPOSE: Clinicians use tamsulosin, an α1-adrenoceptor antagonist, to manage symptomatic benign prostatic hyperplasia (BPH). Because α1-adrenoceptors are also present in the brain, the potential exists for adverse effects on cognitive functions. We explored the association between tamsulosin use and dementia risk. METHODS: We used Medicare data (2006-2012) to conduct a cohort study among patients aged ≥65 years and diagnosed with BPH. Men taking tamsulosin (n = 253 136) were matched at a 1:1 ratio using propensity-scores to each of 6 comparison cohorts: patients who used no BPH-medication (n = 180 926), and patients who used the following alternative-BPH-medications: doxazosin (n = 28 581), terazosin (n = 23 858), alfuzosin (n = 17 934), dutasteride (n = 34 027), and finasteride (n = 38 767)...
January 9, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29312606/induction-of-renal-artery-hyperresponsiveness-by-alpha1-adrenoceptor-in-hepatorenal-syndrome
#5
Xiaogang Zhang, Xinsen Xu, Yina Jiang, Jianyu He, Wenjing Wang, Wei Li, Xufeng Zhang, Yi Lv
Objective: To investigate the potential role of alpha1-adrenoceptor (α1-AR) in the pathogenesis of hepatorenal syndrome. Methods: Hepatorenal syndrome was induced in male rats by intraperitoneal injection of D-galactosamine and orally treatment with α1-AR antagonist tamsulosin. Hyperresponsiveness of the renal artery contraction was evaluated by the laser-Doppler flowmetry and multimyograph system, while renal blood flow (cortical and medullary perfusion) was simultaneously measured...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29309472/purls-tamsulosin-for-patients-with-ureteral-stones
#6
Pamela Hughes, Corey Lyon
A 54-year-old man presents to the emergency department with acute onset left flank pain that radiates to the groin. A computed tomography scan of the abdomen/pelvis without contrast reveals a 7-mm distal ureteral stone. He is deemed appropriate for outpatient management. In addition to pain medications, should you prescribe tamsulosin?
January 2018: Journal of Family Practice
https://www.readbyqxmd.com/read/29299773/a-comparative-epidemiological-study-of-acute-renal-colic-presentations-to-emergency-departments-in-doha-qatar-and-melbourne-australia
#7
Sameer A Pathan, Biswadev Mitra, Zain A Bhutta, Isma Qureshi, Elle Spencer, Asmaa A Hameed, Sana Nadeem, Ramsha Tahir, Shahzad Anjum, Peter A Cameron
BACKGROUND: This study aimed to compare the epidemiology, clinical presentations, management, and outcomes of renal colic presentations in two major academic centers from geographically diverse populations: Qatar (a country in the Afro-Asian stone belt) and South-Eastern Australia (not within a stone belt). METHODS: We undertook a retrospective cohort study of patients with renal colic who presented to the Hamad General Hospital Emergency Department (HGH-ED), Qatar, and The Alfred ED, Melbourne, Australia, during a period of 1 year from August 1, 2012, to July 31, 2013...
January 3, 2018: International Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29275609/-the-study-of-renal-safety-in-elderly-patients-with-benign-prostatic-hyperplasia-treated-with-%C3%AE-receptor-blockers
#8
Z G Ji, D X Dong, Y Xie, Y Zhou, Z E Zhou
Objective: To investigate the renal safety in patients with benign prostatic hyperplasia treated with tamsulosin hydrochloride. Methods: A retrospective analysis of 10 cases of patients, who had renal dysfunction after treatment with long-term tamsulosin hydrochloride. Results: The average duration of oral medicine was 2 to 24 months with an average of 7.2 months. The serum creatinine after discontinuation of tamsulosin hydrochloride decreased from 132.5 μmol/L (100-208 μmol/L, normal 59-104 μmol/L) to 95...
December 12, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29231500/-impacts-of-electroacupuncture-on-benign-prostatic-hyperplasia-and-the-levels-of-estrogen-and-androgen-in-patients
#9
Ruwen Zheng, Hui Hu
OBJECTIVE: To discuss the therapeutic effects of electroacupuncture on benign prostatic hyperplasia and the impacts on hormone levels in the patients. METHODS: Sixty patients were randomized into an electroacupuncture group and a medication group, 30 cases in each one. In the electroacupuncture group, electroacupuncture was applied to Zhongji (CV 3) and Qugu (CV 2), once a day, 5 times a week. In the medication group, tamsulosin hydrochloride sustained-release capsules were prescribed for oral administration, 0...
June 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231344/-the-effect-of-drug-oil-moxibustion-for-contents-of-zinc-and-c-reactive-protein-in-succus-prostaticus-of-chronic-nonbacterial-prostatitis
#10
Wenjun Ma, Qinglin Hu, Lei Diao, Youjin Cai, Jun Feng
OBJECTIVE: To observe the clinical effects differences and partial mechanism for chronic nonbacterial prostatitis (CNP) among drug oil moxibustion, simple moxibustion, and conventional western medicine. METHODS: A total of 120 patients who met the criteria of inclusion were randomly assigned into a drug oil moxibustion group, a moxibustion group and a western medication group, 40 cases in each one. Moxibustion was used at Guanyuan (CV 4), Zhongji (CV 3), Qihai (CV 6) and bilateral Yinlingquan (SP 9), Sanyinjiao (SP 6), Shenshu (BL 23), Mingmen (GV 4), Pangguangshu (BL 28), Ciliao (BL 32), and Zhibian (BL 54), etc...
August 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29204267/tamsulosin-induced-diarrhea-a-case-report
#11
Arunkumar D Rana, Kinjal Dodiya, Manish J Barvaliya, Sameer Shah, Bhargav M Purohit, Chandrabhanu Rajkishor Tripathi
No abstract text is available yet for this article.
December 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29193937/-tamsulosin-oxybutynin-or-their-combination-in-the-treatment-of-ureteral-stent-related-symptoms
#12
Efraín Maldonado-Alcaraz, Jorge Moreno-Palacios, Virgilio A López-Sámano, Claudia Landa-Salas, León O Torres-Mercado, Carlos GarcíaCruz
BACKGROUND: The aim of this paper is to compare the efficacy of tamsulosin, oxybutynin or their combination for the treatment of symptoms related to double J stent (DJS). METHODS: Randomized clinical non-blinded trial with three arms (tamsulosin, oxybutynin or combination) to assess the improvement of ureteral related symptoms with DJS with the questionnaire of Ureteral Stent Symptom Questionnaire (USSQ) and the adverse effects of treatment. Evaluations were made at 7 and 21 days after the placement of DJS...
September 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29186989/treatment-of-distal-ureteral-calculi-using-extracorporeal-physical-vibrational-lithecbole-epvl-combined-with-tamsulosin-a-new-option-to-speed-up-obstruction-relief
#13
Guanlin Liu, Yue Cheng, Weijie Wu, Xiaolong Jia, Jiasheng Hu, Guohai Xie, Xueqin Chen
INTRODUCTION: The obstruction of the urinary tract by calculi at the narrowest anatomical areas leads to impaired drainage and severe pain. The aim of this study was to evaluate a new technology, extracorporeal physical vibrational lithecbole (EPVL) combined with tamsulosin, as a treatment for distal ureteral calculi (DUC). MATERIALS AND METHOD: Between July 2013 and July 2014, 672 patients diagnosed with DUC were randomly divided into 3 groups; a group receiving EPVL plus 0...
November 30, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29183356/outcome-of-uncomplicated-ureteric-calculi-managed-with-medical-expulsive-therapy-in-the-outpatient-clinic-of-a-urology-unit-in-sri-lanka
#14
Malaka Dharmakeerthi Jayawardene, Balasingam Balagobi, A L A M C Ambegoda, Sanjeewa Vidanapathirana, G W A S K Wijayagunawardane, V Senthan, D D Ranasinghe, Anuruddha M Abeygunasekera
OBJECTIVE: Although medical expulsive therapy (MET) is shown to be effective for ureteric calculi, the optimum duration and the stone size suitable for MET are not well established yet. The objectives of the study were to determine the optimum duration and maximum stone size suitable for MET. RESULTS: All patients with radiologically confirmed uncomplicated ureteric calculi treated with MET using tamsulosin over a period of 6 months in the outpatient setting were followed up...
November 28, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29164564/role-of-silodosin-in-patients-with-luts-bpe-non-responding-to-medical-treatment-with-tamsulosin-a-prospective-open-label-pilot-study
#15
S Masciovecchio, A B Di Pasquale, G Ranieri, G Romano, L Di Clemente
OBJECTIVE: Lower urinary tract symptoms (LUTS) are frequently experienced in association with benign prostatic enlargement (BPE). Current guidelines state that alpha-blockers should be considered the first-line therapy of LUTS associated with BPE in most patients. However, in clinical practice treatment efficacy differs among individuals and, therefore, intra-class switch from one alpha-blocker to another, is frequently applied. In particular, switching to silodosin in clinical practice appears an intriguing therapeutic strategy due to the peculiar pharmacological properties of this molecule...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29162627/a-therapeutic-combination-of-gpcr-modulators-that-protects-photoreceptors-from-degeneration
#16
Tivadar Orban, Henri Leinonen, Tamar Getter, Zhiqian Dong, Wenyu Sun, Songqi Gao, Alexander Veenstra, Hossein Heidari-Torkabadi, Timothy S Kern, Philip D Kiser, Krzysztof Palczewski
Degeneration of retinal photoreceptor cells can arise from environmental and/or genetic causes. Since photoreceptor cells, the retinal pigment epithelium (RPE), neurons and glial cells of the retina are intimately associated; all cell types eventually are affected by retinal degenerative diseases. Such diseases often originate either in rod and/or cone photoreceptor cells or the RPE. Of these, cone cells located in the central retina are especially important for daily human activity. Here we describe the protection of cone cells by a combination therapy consisting of the G protein-coupled receptor modulators metoprolol, tamsulosin, and bromocriptine...
November 21, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29161773/silodosin-for-the-treatment-of-lower-urinary-tract-symptoms-in-men-with-benign-prostatic-hyperplasia
#17
REVIEW
Jae Hung Jung, Jiye Kim, Roderick MacDonald, Balaji Reddy, Myung Ha Kim, Philipp Dahm
BACKGROUND: A variety of alpha-blockers are used for treating lower urinary tract symptoms (LUTS) in men with benign prostatic hyperplasia (BPH). Silodosin is a novel, more selective alpha-blocker, which is specific to the lower urinary tract and may have fewer side effects than other alpha-blockers. OBJECTIVES: To assess the effects of silodosin for the treatment of LUTS in men with BPH. SEARCH METHODS: We performed a comprehensive search using multiple databases (Cochrane Library, MEDLINE, EMBASE, Scopus, Google Scholar, and Web of Science), trials registries, other sources of grey literature, and conference proceedings with no restrictions on the language of publication or publication status up until 13 June 2017...
November 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29137830/efficacy-and-safety-of-tamsulosin-in-medical-expulsive-therapy-for-distal-ureteral-stones-with-renal-colic-a-multicenter-randomized-double-blind-placebo-controlled-trial
#18
Zhangqun Ye, Guohua Zeng, Huan Yang, Kun Tang, Xiaochun Zhang, Hong Li, Weibing Li, Zhong Wu, Lingwu Chen, Xingfa Chen, Xiankui Liu, Yaoliang Deng, Tiejun Pan, Jinchun Xing, Shusheng Wang, Yue Cheng, Xiaojian Gu, Wenxi Gao, Jianggen Yang, Yonghai Zhang, Qiwu Mi, Lin Qi, Jiongming Li, Weilie Hu, Peiyu Liang, Zhaolin Sun, Changbao Xu, Yongfu Long, Yongbin Liao, Siping Liu, Guoqing Liu, Xun Xu, Wei He, Zhiqiang Chen, Hua Xu
BACKGROUND: Recent large high-quality trials have questioned the clinical effectiveness of medical expulsive therapy using tamsulosin for ureteral stones. OBJECTIVE: To evaluate the efficacy and safety of tamsulosin for distal ureteral stones compared with placebo. DESIGN, SETTING, AND PARTICIPANTS: We conducted a double-blind, placebo-controlled study of 3296 patients with distal ureteral stones, across 30 centers, to evaluate the efficacy and safety of tamsulosin...
November 11, 2017: European Urology
https://www.readbyqxmd.com/read/29135144/-the-use-of-prostadoz-in-patients-with-benign-prostatic-hyperplasia-and-coexistent-high-grade-prostatic-intraepithelial-neoplasia
#19
A G Antonov, V V Gordeev, S B Fedorchuk, D O Laptev
INTRODUCTION: In recent years there has been an increasing interest in the drug treatment of benign prostatic hyperplasia (BPH) to improve the patients quality of life without surgical treatment. In this connection, phytotherapeutic drugs and biologically active dietary supplements (BADS), consisting of a combination of microelements, vitamins and plant extracts, have been increasingly used in addition to synthetic preparations. OBJECTIVE: To investigate the clinical effectiveness of dietary supplement ProstaDoz in the treatment of BPH with coexistent high-grade prostatic intraepithelial neoplasia (PIN)...
October 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29135141/-effectiveness-of-omnic-and-omnic-ocas-in-patients-with-lower-urinary-tract-symptoms-secondary-to-benign-prostatic-hyperplasia-multi-center-observing-program
#20
B U Shalekenov, Y A Kuandykov, S B Shalekenov
AIM: To investigate the effectiveness and safety of six-month treatment course of Omnic and Omnic Ocas in patients with lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) in a routine urology practice in Kazakhstan. DESIGN: This was a multicenter prospective observational program involving the collection of data from patients with LUTS caused by BPH, who received Omnic Ocas or Omnic as the first line treatment. MATERIALS AND METHODS: The program comprised 1513 patients with a verified diagnosis of LUTS/BPH, who received Omnic Ocas or Omnic (tamsulosin) administered by urologists at hospitals in the Republic of Kazakhstan...
October 2017: Urologii︠a︡
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