Rita de Cássia Calderaro Coelho, Carlliane Lima E Lins Pinto Martins, Lucas Favacho Pastana, Juliana Carla Gomes Rodrigues, Kaio Evandro Cardoso Aguiar, Amanda de Nazaré Cohen-Paes, Laura Patrícia Albarello Gellen, Francisco Cezar Aquino de Moraes, Maria Clara Leite Calderaro, Letícia Almeida de Assunção, Natasha Monte, Esdras Edgar Batista Pereira, André Maurício Ribeiro-Dos-Santos, Ândrea Ribeiro-do-Santos, Rommel Mario Rodriguez Burbano, Sandro José de Souza, João Farias Guerreiro, Paulo Pimentel de Assumpção, Sidney Emanuel Batista Dos Santos, Marianne Rodrigues Fernandes, Ney Pereira Carneiro Dos Santos
Coronavirus disease 2019 (COVID-19) is an infection caused by SARS-CoV-2. Genome-wide association studies (GWASs) have suggested a strong association of genetic factors with the severity of the disease. However, many of these studies have been completed in European populations, and little is known about the genetic variability of indigenous peoples' underlying infection by SARS-CoV-2. The objective of the study is to investigate genetic variants present in the genes AQP3 , ARHGAP27 , ELF5L , IFNAR2 , LIMD1 , OAS1 and UPK1A, selected due to their association with the severity of COVID-19, in a sample of indigenous people from the Brazilian Amazon in order to describe potential new and already studied variants...
February 26, 2024: Viruses