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JOURNAL ARTICLE
Haojun Li, Runa Zhao, Yingna Pan, Hui Tian, Wenlong Chen
Limax maximus, or great gray slug, is a common agriculture pest. The pest infests crops during their growth phase, creating holes in vegetable leaves, particularly in seedlings and tender leaves. A study was conducted to assess the insecticidal activity of Ageratina adenophora extract against these slugs. Factors such as fecundity, growth, hatching rate, offspring survival rate, protective enzyme activity, and detoxifying enzyme activity were examined in slugs exposed to the extract's sublethal concentration (LC50) for two different durations (24 and 48 h)...
2024: PloS One
#2
JOURNAL ARTICLE
Thomas Köhler, Elke Schwier, Janina Praxenthaler, Carmen Kirchner, Günther Winde, Björn Koos, Dietrich Henzler
PURPOSE: Liver function of intensive care patients is routinely monitored by static blood pathology. For specific indications, liver specific cytochrome activity may be measured by the commercially available maximum liver function capacity (LiMAx) test via quantification of the cytochrome P450 1A2 (CYP1A2) dependent C-methacetin metabolism. Sedation with the volatile anesthetic isoflurane was suspected to abrogate the correlation of LiMAx test with global liver function. We hypothesized that isoflurane has a CYP1A2-activity and LiMAx test result decreasing effect...
April 8, 2024: Intensive Care Medicine Experimental
#3
JOURNAL ARTICLE
M A Cortes, W Bert, M Couvreur, D De Waele, P R Singh
A survey for slug- and snail-associated nematodes was conducted in forests, parks, botanical gardens, and nature reserves at 13 localities in Belgium to uncover more diversity of gastropod mollusc-associated nematodes and to characterise Pellioditis populations found in the country. A total of 319 slugs and snails belonging to nine species were examined. Arion vulgaris was the most commonly found mollusc species in this study (eight locations), and 19.4% of the examined mollusc specimens were found infected by nematodes...
March 21, 2024: Journal of Helminthology
#4
JOURNAL ARTICLE
Jonas Santol, Markus Ammann, Tim Reese, Anna E Kern, Valerie Laferl, Felix Oldhafer, Yawen Dong, Benedikt Rumpf, Marjan Vali, Bengt Wiemann, Gregor Ortmayr, Sarah E Brunner, Joel Probst, Monika Aiad, Anna S Jankoschek, Mariel Gramberger, Madita M Tschoegl, Mohamed Salem, Niccolò Surci, Rebecca Thonhauser, Vulnet Mazari, Thomas Hoblaj, Sabine Thalhammer, Moritz Schmelzle, Karl J Oldhafer, Thomas Gruenberger, Patrick Starlinger
INTRODUCTION: Posthepatectomy liver failure (PHLF) remains the main reason for short-term mortality after liver surgery. APRI+ALBI, aspartate aminotransferase to platelet ratio (APRI) combined with albumin-bilirubin grade (ALBI), score and the liver function maximum capacity test (LiMAx) are both established preoperative (preop) liver function tests. The aim of this study was to compare both tests for their predictive potential for clinically significant PHLF grade B and C (B+C). MATERIALS AND METHODS: 352 patients were included from 4 European centers...
February 21, 2024: European Journal of Surgical Oncology
#5
JOURNAL ARTICLE
Yuko Matsuo, Airi Kawakami, Ryota Matsuo
Terrestrial gastropods have a lens-bearing eye on the tip of their tentacles. There are two morphologically distinct photoreceptors, called Type-I and Type-II photoreceptors, in the retina. Type-I photoreceptors are equipped with highly developed photoreceptive microvilli in their outer rhabdomeric segment, whereas Type-II photoreceptors have short and fewer microvilli. Although both types of photoreceptors send afferent projections directly to the brain, their destinations in the brain, called optic neuropiles, have not been sufficiently investigated...
March 2024: Journal of Comparative Neurology
#6
JOURNAL ARTICLE
Felix Rühlmann, Azadeh Azizian, Christian Moosmann, Markus Bernhardt, Jan Keck, Hannah Flebbe, Omar Al-Bourini, Ali Seif Amir Hosseini, Marian Grade, Thomas Lorf, Michael Ghadimi, Thorsten Perl, Jochen Gaedcke
BACKGROUND: Postoperative liver failure (PLF) is a severe complication after major liver resection (MLR). To increase the safety of patients, clinical bedside tests are of great importance. However, limitations of their applicability and validity impair their value. METHODS: Preoperative measurements of the liver maximum capacity (LiMAx) were performed in n = 40 patients, who underwent MLR (≥3 segments). Matched postoperative LiMAx was measured in n = 21 patients...
January 23, 2024: Biomedicines
#7
JOURNAL ARTICLE
Ryota Matsuo, Mitsumasa Koyanagi, Tomohiro Sugihara, Taishi Shirata, Takashi Nagata, Keiichi Inoue, Yuko Matsuo, Akihisa Terakita
BACKGROUND: Rhabdomeric photoreceptors of eyes in the terrestrial slug Limax are the typical invertebrate-type but unique in that three visual opsins (Gq-coupled rhodopsin, xenopsin, Opn5A) and one retinochrome, all belonging to different groups, are co-expressed. However, molecular properties including spectral sensitivity and G protein selectivity of any of them are not determined, which prevents us from understanding an advantage of multiplicity of opsin properties in a single rhabdomeric photoreceptor...
December 18, 2023: BMC Biology
#8
JOURNAL ARTICLE
Haifaa A Mahjoub, Daniela Bedenice, Henrik Stryhn, Jenny Yu, Spencer J Greenwood, Gary A Conboy
OBJECTIVE: This study determined the in vitro efficacy of 6 common anthelmintics (eprinomectin, ivermectin, milbemycin oxime, moxidectin, selamectin, and fenbendazole) on motility (viability) of infectious third-stage larvae (L3) of Crenosoma vulpis, Angiostrongylus vasorum, and Aelurostrongylus abstrusus, which are important causes of canine and feline cardiopulmonary disease. SAMPLES: First-stage larvae (L1) from C vulpis, An vasorum, and Ae abstrusus. PROCEDURES: Naïve Limax maximus slugs were fed 1,000 to 2,000 L1 and held at 16 °C for at least 4 weeks to produce live L3...
December 22, 2023: American Journal of Veterinary Research
#9
JOURNAL ARTICLE
Georgios Makridis, Tim Reese, Zoltán S Zádori, Anna I Suling, Maria Stark, Katja Horling, Roland Brüning, Martin A Schneider, Michael Beumer, Karl J Oldhafer
BACKGROUND: As prevention of posthepatectomy-liver-failure is crucial, there is need of dynamic assessment of liver function, even intraoperatively. 13 C-methacetin-breath-test estimates the organ's microsomal functional capacity. This is its first intraoperative evaluation in major liver surgery. METHODS: 30 patients planed for resection of ≥3 liver segments, between March-November 2019, were prospectively enrolled in this "single-center", pilot study. Using the 13 C-methacetin-breath-test, liver function was assessed four times: preoperatively, intraoperatively before and after resection and postoperatively...
September 6, 2023: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
#10
JOURNAL ARTICLE
Karin Senk, Carolina Rio Bartulos, Juliane Wilcke, Ingo Einspieler, Lukas Lürken, Wolf Baeumler, Christian Stroszczynski, Philipp Wiggermann
BACKGROUND: Local ablation is an important treatment for liver cancer in cases of cirrhosis. Liver failure may occur after ablation, especially in advanced liver diseases. Currently, there is no standardization for peri-interventional risk assessment. The liver maximum capacity test (LiMAx) is used to assess functional liver capacity, but there is a lack of exploration of its use in this context. OBJECTIVE: The aim of this study was to retrospectively evaluate the usefulness of peri-interventional LiMAx measurements in patients with primary or secondary liver cancer who underwent ablation treatment...
August 25, 2023: Clinical Hemorheology and Microcirculation
#11
JOURNAL ARTICLE
Louis M J Vandekerckhove, Stijn Herregodts, Jimmy H Saunders, Bart J G Broeckx
OBJECTIVE: While it has been known for a long time that laxity in the hip joint is the primary cause of degenerative changes later on in canine hip dysplasia, limited data are available on the fundamental characteristics that define the procedure used to quantify this. The aim of this study was to evaluate the force-laxity relation to assess the repeatability of repeated cycles of stress on the hip joint and determine the force necessary tomeasure a sufficient proportion of laxity present in hip joints...
August 23, 2023: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
#12
JOURNAL ARTICLE
Florian Primavesi, Manuel Maglione, Federica Cipriani, Timm Denecke, Christian E Oberkofler, Patrick Starlinger, Bobby V M Dasari, Jan Heil, Olivia Sgarbura, Kjetil Søreide, Rafael Diaz-Nieto, Constantino Fondevila, Adam E Frampton, Dominik Geisel, Benjamin Henninger, Amelia J Hessheimer, Mickaël Lesurtel, Damian Mole, Robert Öllinger, Pim Olthof, Thomas Reiberger, Andreas A Schnitzbauer, Christoph Schwarz, Ernesto Sparrelid, Martin Stockmann, Stéphanie Truant, Luca Aldrighetti, Eva Braunwarth, Mathieu D'Hondt, Michelle L DeOliveira, Joris Erdmann, David Fuks, Thomas Gruenberger, Klaus Kaczirek, Hassan Malik, Dietmar Öfner, Nuh N Rahbari, Georg Göbel, Ajith K Siriwardena, Stefan Stättner
BACKGROUND: Posthepatectomy liver failure (PHLF) contributes significantly to morbidity and mortality after liver surgery. Standardized assessment of preoperative liver function is crucial to identify patients at risk. These European consensus guidelines provide guidance for preoperative patient assessment. METHODS: A modified Delphi approach was used to achieve consensus. The expert panel consisted of hepatobiliary surgeons, radiologists, nuclear medicine specialists, and hepatologists...
August 12, 2023: British Journal of Surgery
#13
JOURNAL ARTICLE
Kat L Parmar, Derek O'Reilly, Juan Valle, Michael Braun, Lee Malcomson, Robert P Jones, Fady Balaa, Myrddin Rees, Fenella K S Welsh, Rafik Filobbos, Andrew G Renehan
INTRODUCTION: Liver resection is the only curative treatment for colorectal liver metastases (CLM). Resectability decision-making is therefore a key determinant of outcomes. Wide variation has been demonstrated in resectability decision-making, despite the existence of criteria. This paper summarises a study protocol to evaluate the potential added value of two novel assessment tools in assessing CLM technical resectability: the Hepatica preoperative MR scan (MR-based volumetry, Couinaud segmentation, liver tissue characteristics and operative planning tool) and the LiMAx test (hepatic functional capacity)...
March 30, 2023: BMJ Open
#14
JOURNAL ARTICLE
M Viketoft, N E Zygouridis, S Emery
Slugs are important agricultural pests causing yearly yield losses. However, parasitizing helminths potentially could affect the size of the slug population. Here, a survey of terrestrial slug-parasitic helminths (nematodes and trematodes) was conducted for the first time in Sweden. In total, 268 terrestrial slugs were collected from 27 agricultural field edges in three seasons over 2020 and 2021 and dissected for presence of helminth parasites. Slugs belonging to the genus Arion were molecularly identified by mitochondrial DNA cytochrome c oxidase subunit I (COI) while parasites were identified using ribosomal RNA (18S)...
February 23, 2023: Journal of Helminthology
#15
JOURNAL ARTICLE
Robbie Rae
Avoidance of pathogens and parasites is the first line of defense to survive. Several slug species avoid the parasitic nematode Phasmarhabditis hermaphrodita to reduce infection however, there is nothing known about whether slugs avoid other members of the Phasmarhabditis genus. I exposed two slug species (Deroceras invadens and Limax maculatus) to Phasmarhabditis californica and P. neopapillosa. D. invadens avoided P. californica but was strangely attracted to P. neopapillosa. L. maculatus did not avoid P...
February 7, 2023: Journal of Invertebrate Pathology
#16
JOURNAL ARTICLE
Janett Fischer, Stella Wellhöner, Sebastian Ebel, Thomas Lincke, Albrecht Böhlig, Florian Gerhardt, Rhea Veelken, Holger Goessmann, Karen Geva Steinhoff, Timm Denecke, Osama Sabri, Thomas Berg, Florian van Bömmel
Transarterial chemoembolization (TACE) and transarterial radioembolization (TARE) are recommended to treat patients with early or intermediate hepatocellular carcinoma (HCC). The liver maximum capacity test (LiMAx) has been supposed to predict the risk of post-interventional liver failure. We investigated the correlation of LiMAx with short-term survival as primary endpoint and the occurrence of adverse events after therapy as secondary endpoint. Our study cohort prospectively included 69 patients receiving TACE (n = 57) or TARE (n = 12)...
October 28, 2022: Cancers
#17
REVIEW
Matthias Buechter, Guido Gerken
Acute and chronic liver disease is a relevant problem worldwide. Liver function plays a crucial role in the course of liver diseases not only in estimating prognosis but also with regard to therapeutic interventions. Within this review, we discuss and evaluate different tools from screening to diagnosis and give insights from personal experiences, controlled clinical studies and future perspectives. Finally, we offer our novel diagnostic algorithm to screen patients with presumptive acute or chronic liver disease in the daily clinical routine...
October 5, 2022: Journal of Personalized Medicine
#18
JOURNAL ARTICLE
Janina Praxenthaler, Elke Schwier, Simon Altmann, Carmen Kirchner, Julian Bialas, Dietrich Henzler, Thomas Köhler
BACKGROUND: Sepsis is often associated with liver dysfunction, which is an indicator of poor outcomes. Specific diagnostic tools that detect hepatic dysfunction in its early stages are scarce. So far, the immune modulatory effects of hemoadsorption with CytoSorb® on liver function are unclear. METHOD: We assessed the hepatic function by using the dynamic LiMAx® test and biochemical parameters in 21 patients with sepsis or septic shock receiving CytoSorb® in a prospective, observational study...
September 20, 2022: Biomedicines
#19
JOURNAL ARTICLE
Thomas Minor, Charlotte von Horn, Hristo Zlatev, Fuat Saner, Melanie Grawe, Bastian Lüer, Eva-Maria Huessler, Nils Kuklik, Andreas Paul
Abrupt return to normothermia has been shown a genuine factor contributing to graft dysfunction after transplantation. This study tested the concept to mitigate reperfusion injury of liver grafts by gentle warming-up using ex vivo machine perfusion prior to reperfusion. In a single center randomized controlled study, livers were assigned to conventional static cold storage (SCS) alone or to SCS followed by 90 min of ex vivo machine perfusion including controlled oxygenated rewarming (COR) by gentle and protracted elevation of the perfusate temperature from 10°C to 20°C...
October 17, 2022: Clinical and Translational Science
#20
JOURNAL ARTICLE
Catherine Leyh, Niklas Heucke, Clemens Schotten, Matthias Büchter, Lars P Bechmann, Marc Wichert, Alexander Dechêne, Ken Herrmann, Dominik Heider, Svenja Sydor, Peter Lemmer, Johannes M Ludwig, Josef Pospiech, Jens Theysohn, Robert Damm, Christine March, Maciej Powerski, Maciej Pech, Mustafa Özcürümez, Jochen Weigt, Verena Keitel, Christian M Lange, Hartmut Schmidt, Ali Canbay, Jan Best, Guido Gerken, Paul P Manka
BACKGROUND AND AIMS: Radioembolization (RE) has recently demonstrated a non-inferior survival outcome compared to systemic therapy for advanced hepatocellular carcinoma (HCC). Therefore, current guidelines recommend RE for patients with advanced HCC and preserved liver function who are unsuitable for transarterial chemoembolization (TACE) or systemic therapy. However, despite the excellent safety profile of RE, post-therapeutic hepatic decompensation remains a serious complication that is difficult to predicted by standard laboratory liver function parameters or imaging modalities...
September 21, 2022: Cancers
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