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https://www.readbyqxmd.com/read/28742055/kinetic-validation-of-the-limax-test-during-10-000-intravenous-13c-methacetin-breath-tests
#1
Tom Moses Rubin, Karsten Heyne, Axel Luchterhand, Jan Bednarsch, Florian W Vondran, Georgios Polychronidis, Maciej Malinowski, Alen Nikolic, Hans-Michael Tautenhahn, Maximilian Jara, Tilo Wuensch, Martin Stockmann, Johan Friso Lock
The LiMAx test, a novel 13C-methacetin-breath-test, has proven clinical validity in determining the hepatic metabolic capacity. In contrast to prior 13C-methacetin-breath-test protocols, the LiMAx-test is performed by intravenous body-weight adjusted substrate administration. Furthermore, the DOB kinetics (Delta over Baseline of the time dependent exhaled 13CO2/12CO2-ratio) are measured online at bedside with a high time resolution in order to determine the DOB maximum. The aim of this study was to analyze the recorded DOB kinetics in a large population for further refinement of the test protocol...
July 25, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28717946/spontaneous-shedding-of-metastrongyloid-third-stage-larvae-by-experimentally-infected-limax-maximus
#2
Gary Conboy, Nicole Guselle, Roland Schaper
No abstract text is available yet for this article.
July 17, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28711678/linezolid-in-liver-failure-exploring-the-value-of-the-maximal-liver-function-capacity-limax-test-in-a-pharmacokinetic-pilot-study
#3
Sebastian G Wicha, Otto R Frey, Anka C Roehr, Johann Pratschke, Martin Stockmann, Rawan Alraish, Tilo Wuensch, Magnus Kaffarnik
BACKGROUND: Patients in the intensive care unit frequently require antibiotic treatment. Liver impairment possesses substantial challenges for dose selection in these patients. The aim of the present pilot study was to assess the novel maximal liver function capacity (LiMAx test) in comparison to conventional liver function markers as covariates of drug clearance in liver failure using linezolid as model drug. METHODS: 28 patients with different degrees of liver failure were recruited and LiMAx test, plasma, dialysis and urine sampling was performed under linezolid steady-state therapy (600 mg BID)...
July 12, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28687596/expression-and-light-dependent-translocation-of-%C3%AE-arrestin-in-the-visual-system-of-the-terrestrial-slug-limax-valentianus
#4
Ryota Matsuo, Yuka Takatori, Shun Hamada, Mitsumasa Koyanagi, Yuko Matsuo
Vertebrates, cephalopods, and arthropods are equipped with eyes having the highest spatiotemporal resolution among the animal phyla. In parallel, it is only the animals in these three phyla that have visual arrestin specialized for the termination of visual signaling triggered by opsin, in addition to ubiquitously expressed β-arrestin that serves in terminating general G protein-coupled receptor signaling. Indeed, visual arrestin in Drosophila and rodents translocates to the opsin-rich subcellular region in response to light to reduce the overall sensitivity of photoreceptors in an illuminated environment (i...
July 7, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28615470/identification-of-the-group-b-streptococcus-capsule-type-using-a-dual-phenotypic-genotypic-assay
#5
Areej Alhhazmi, Armaan Pandey, Gregory J Tyrrell
The Group B streptococcus (GBS) capsular polysaccharide (CPS) is an important virulence factor which is also used for GBS typing. There are 10 CPS types (Ia, Ib and II-IX). GBS that do not phenotypically type are considered non-typable. All genes required for CPS synthesis are found on the GBS cps operon, which contains a highly variable CPS-determining region (cpsG-cpsK).The objective of this study was development of an assay to detect sialic acid on the GBS cell surface followed by a genotypic PCR CPS typing assay...
June 14, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28542386/correlation-between-plasma-endothelin-1-levels-and-severity-of-septic-liver-failure-quantified-by-maximal-liver-function-capacity-limax-test-a-prospective-study
#6
Magnus F Kaffarnik, Navid Ahmadi, Johan F Lock, Tilo Wuensch, Johann Pratschke, Martin Stockmann, Maciej Malinowski
AIM: To investigate the relationship between the degree of liver dysfunction, quantified by maximal liver function capacity (LiMAx test) and endothelin-1, TNF-α and IL-6 in septic surgical patients. METHODS: 28 septic patients (8 female, 20 male, age range 35-80y) were prospectively investigated on a surgical intensive care unit. Liver function, defined by LiMAx test, and measurements of plasma levels of endothelin-1, TNF-α and IL-6 were carried out within the first 24 hours after onset of septic symptoms, followed by day 2, 5 and 10...
2017: PloS One
https://www.readbyqxmd.com/read/28516292/limax-test-improves-diagnosis-of-chemotherapy-associated-liver-injury-before-resection-of-colorectal-liver-metastases
#7
Johan F Lock, Tilman Westphal, Tom Rubin, Maciej Malinowski, Antje Schulz, Maximilian Jara, Jan Bednarsch, Martin Stockmann
BACKGROUND: Chemotherapy of colorectal liver metastases (CLMs) prior to liver resection implies the risk of chemotherapy-associated liver injury, leading to increased postoperative morbidity and mortality OBJECTIVE: The aim of this study was to evaluate the LiMAx (liver maximum capacity) test for diagnosis of chemotherapy-associated liver injury. METHODS: This was a retrospective analysis of patients with CLMs, prior to liver resection. We performed preoperative assessment of liver function using biochemical parameters and the LiMAx test...
May 17, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28293872/effect-of-high-laser-output-on-the-central-bronchi-and-pulmonary-artery
#8
A Kirschbaum, P Rexin, D K Bartsch, K Quint
A diode-pump Nd:YAG high-power laser (wavelength 1320 nm, power 100 W) is routinely used to surgically remove lung metastases. Even pulmonary lesions in central locations are resectable via this method, yet it also carries a potential risk of damaging the larger bronchi and vessels in the vicinity. Studies investigating the safety of using high-power lasers are lacking. We therefore aimed to examine the direct effects of a 100-watt laser on the bronchi and pulmonary artery at a standard working velocity. From freshly slaughtered pigs, we isolated cylindrical specimens of the trachea, the main and lobar bronchi, and the central pulmonary artery from the both lungs...
May 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28241370/evolution-of-laparoscopic-liver-surgery-as-standard-procedure-for-hcc-in-cirrhosis
#9
Daniel Seehofer, Robert Sucher, Moritz Schmelzle, Robert Öllinger, Andri Lederer, Timm Denecke, Eckart Schott, Johann Pratschke
Patients with hepatocellular carcinoma (HCC) in cirrhosis have an increased risk for postoperative complications including liver failure. However, there is some evidence that the use of laparoscopy markedly decreases this risk. Patients Between 2010 - 2015, a total of 21 laparoscopic liver resections were performed for HCC in Child-A cirrhosis at our center. Mean MELD score was 9 (6 - 12), and the mean LiMAx was 261 µg/h/kg (101 - 489). All resections were performed by conventional laparoscopy using 4 - 6 trocars...
May 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/28196354/effect-of-age-on-liver-function-in-patients-undergoing-partial-hepatectomy
#10
T M Lodewick, P H Alizai, R M van Dam, A A J Roeth, M Schmeding, C Heidenhain, A Andert, N Gassler, C H C Dejong, U P Neumann
BACKGROUND: Postresectional liver failure is the most frequent cause of fatal outcome following liver surgery. Diminished preoperative liver function in the elderly might contribute to this. Therefore, the aim of the present study was to evaluate preoperative liver function in patients <60 or >70 years of age scheduled for liver resection. METHODS: All consecutive patients aged <60 or >70 years who are about to undergo elective liver surgery between 2011 and 2013 and underwent the methacetin breath liver function test (LiMAx) preoperatively were included...
2017: Digestive Surgery
https://www.readbyqxmd.com/read/28143510/gastropod-derived-haemocyte-extracellular-traps-entrap-metastrongyloid-larval-stages-of-angiostrongylus-vasorum-aelurostrongylus-abstrusus-and-troglostrongylus-brevior
#11
Malin K Lange, Felipe Penagos-Tabares, Tamara Muñoz-Caro, Ulrich Gärtner, Helena Mejer, Roland Schaper, Carlos Hermosilla, Anja Taubert
BACKGROUND: Phagocyte-derived extracellular traps (ETs) were recently demonstrated mainly in vertebrate hosts as an important effector mechanism against invading parasites. In the present study we aimed to characterize gastropod-derived invertebrate extracellular phagocyte trap (InEPT) formation in response to larval stages of important canine and feline metastrongyloid lungworms. Gastropod haemocytes were isolated from the slug species Arion lusitanicus and Limax maximus, and the snail Achatina fulica, and exposed to larval stages of Angiostrongylus vasorum, Aelurostrongylus abstrusus and Troglostrongylus brevior and investigated for gastropod-derived InEPT formation...
January 31, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/27785464/phase-dependent-modulation-of-oscillatory-phase-and-synchrony-by-long-lasting-depolarizing-inputs-in-central-neurons
#12
Satoshi Watanabe, Moritoshi Hirono
Oscillatory neural activities have been implicated in various types of information processing in the CNS. The procerebral (PC) lobe of the land mollusk Limax valentianus shows an ongoing oscillatory local field potential (LFP). Olfactory input increases both the frequency and spatial synchrony of the LFP oscillation by a nitric oxide (NO)-mediated mechanism, but how NO modulates the activity in a specific manner has been unclear. In the present study, we used electrical stimulation and NO uncaging to systematically analyze the response of the LFP oscillation and found phase-dependent effects on phase shifting and synchrony...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27632190/the-impact-of-directly-acting-antivirals-on-the-enzymatic-liver-function-of-liver-transplant-recipients-with-recurrent-hepatitis-c
#13
Nathanael Raschzok, Eckart Schott, Anja Reutzel-Selke, Iman Damrah, Safak Gül-Klein, Benjamin Strücker, Igor Maximilian Sauer, Johann Pratschke, Dennis Eurich, Martin Stockmann
BACKGROUND: The new directly acting antivirals (DAAs) enable all-oral interferon-free treatment of chronic hepatitis C virus (HCV) infection. We here investigated the effect of DAAs on the enzymatic liver function of liver transplant recipients with recurrent hepatitis C. METHODS: Twenty-one patients with elevated liver enzymes or advanced fibrosis/compensated cirrhosis caused by recurrent HCV were treated with sofosbuvir either in combination with simeprevir, or in combination with ribavirin or daclatasvir with or without ribavirin for 12 weeks...
December 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/27497918/length-of-the-memory-retention-period-depends-on-the-extent-of-protein-synthesis-in-the-terrestrial-slug-limax
#14
Yuko Suenaga, Ryota Matsuo
The terrestrial slug Limax can form an odor-aversion memory by the single simultaneous presentation of a food odor and an aversive stimulus. We have previously demonstrated that the long-term retention of this memory was impaired by a high-dose injection of a protein synthesis inhibitor 30min prior to the conditioning. However, the onset of amnesia was delayed if the dose of the inhibitor was reduced or a less potent protein synthesis inhibitor was used. We thus speculated that the persistence of memory depends on the amount of newly synthesized protein following learning...
September 6, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27293483/monitoring-of-liver-function-in-a-73-year-old-patient-undergoing-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-case-report-applying-the-novel-liver-maximum-function-capacity-test
#15
Felix Oldhafer, Kristina I Ringe, Kai Timrott, Moritz Kleine, Wolf Ramackers, Sebastian Cammann, Mark D Jäger, Juergen Klempnauer, Hueseyin Bektas, Florian W R Vondran
BACKGROUND: The two-stage liver resection combining in situ liver transection with portal vein ligation, also referred to as ALPPS (Associating Liver Partition and Portal vein ligation for Staged hepatectomy), has been described as a promising method to increase the resectability of liver tumors. However, one of the most important issues regarding the safety of this procedure is the optimal timing of the second stage at the point of sufficient hypertrophy of the future liver remnant. The recently developed liver maximum function capacity test (LiMAx) can be applied to monitor the liver function postoperatively and hence could be a useful tool for decision-making regarding the timing of the second stage of ALPPS...
2016: Patient Safety in Surgery
https://www.readbyqxmd.com/read/27274881/application-of-the-liver-maximum-function-capacity-test-in-acute-liver-failure-a-helpful-tool-for-decision-making-in-liver-transplantation
#16
Florian Wolfgang Rudolf Vondran, Carsten Schumacher, Kai Johanning, Björn Hartleben, Wolfgang Knitsch, Olaf Wiesner, Elmar Jaeckel, Michael Peter Manns, Juergen Klempnauer, Hueseyin Bektas, Frank Lehner
Background. Despite aggressive intensive medical management acute liver failure (ALF) may require high-urgency liver transplantation (LTx). Available prognostic scores do not apply for all patients; reliable tools to identify individuals in need of LTx are highly required. The liver maximum function capacity test (LiMAx) might represent an appropriate option. Referring to a case of ALF after Amanita phalloides-intoxication the potential of the LiMAx-test in this setting is discussed. Presentation of Case. LiMAx was performed in a 27-year-old patient prior to and after high-urgency LTx...
2016: Case Reports in Transplantation
https://www.readbyqxmd.com/read/27187577/octopaminergic-system-in-the-central-nervous-system-of-the-terrestrial-slug-limax
#17
Ryota Matsuo, Marin Tanaka, Rena Fukata, Suguru Kobayashi, Hitoshi Aonuma, Yuko Matsuo
The terrestrial slug Limax can learn to avoid the odor of some food (e.g., carrot juice) by the simultaneous presentation of an aversive stimulus (e.g., bitterness of quinidine). This type of associative memory critically depends on the higher olfactory center, the procerebrum in the central nervous system. The modulation of the local field potential (LFP) oscillation recorded on the procerebrum has been thought to reflect the information processing of the odor that elicits the behavioral change, such as avoidance of the aversively learned odor or approaching an attractive food's odor...
December 15, 2016: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/27164934/regeneration-of-liver-function-capacity-after-partial-liver-resection-is-impaired-in-case-of-postoperative-bile-leakage
#18
Jan Bednarsch, Elisabeth Blüthner, Maciej Malinowski, Daniel Seehofer, Johann Pratschke, Martin Stockmann
BACKGROUND: Postoperative bile leakage (PBL) is a major surgical complication after partial liver resection resulting in increased perioperative morbidity and mortality. Previous experimental studies have shown an adverse effect on functional liver regeneration, but there are still no data available concerning these effects in humans. MATERIALS AND METHODS: A retrospective matched pair analysis was carried out comparing the postoperative course of 51 patients with PBL to 51 patients without PBL...
September 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/26853872/olfactory-memory-storage-and-or-retrieval-requires-the-presence-of-the-exact-tentacle-used-during-memory-acquisition-in-the-terrestrial-slug-limax
#19
Yurika Koga, Yuko Matsuo, Ryota Matsuo
Terrestrial pulmonates can form odor-aversion memories once a food odor is presented in combination with an aversive stimulus. Most of the olfactory information ascends via a tentacular ganglion located in the tip of the two pairs of tentacles, and is then transmitted to the higher olfactory center, the procerebrum. The procerebrum is the locus of memory storage and has been shown to be necessary for odor-aversion learning. However, it is unknown whether the procerebrum is the sole locus in which the memory engram resides...
February 2016: Zoological Science
https://www.readbyqxmd.com/read/26739618/video-thoracoscopic-resection-of-lung-metastases-using-the-nd-yag-laser-limax%C3%A2-120
#20
Andreas Kirschbaum, Christian Meyer, Detlef K Bartsch
No abstract text is available yet for this article.
December 16, 2015: Journal of Cardiothoracic Surgery
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