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https://www.readbyqxmd.com/read/29727853/strategic-grazing-management-towards-sustainable-intensification-at-tropical-pasture-based-dairy-systems
#1
Guilhermo F S Congio, Camila D A Batalha, Marília B Chiavegato, Alexandre Berndt, Patrícia P A Oliveira, Rosa T S Frighetto, Thomas M R Maxwell, Pablo Gregorini, Sila C Da Silva
Agricultural systems are responsible for environmental impacts that can be mitigated through the adoption of more sustainable principles. Our objective was to investigate the influence of two pre-grazing targets (95% and maximum canopy light interception during pasture regrowth; LI95% and LIMax , respectively) on sward structure and herbage nutritive value of elephant grass cv. Cameroon, and dry matter intake (DMI), milk yield, stocking rate, enteric methane (CH4 ) emissions by Holstein × Jersey dairy cows...
May 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29441415/novel-approach-to-study-gastropod-mediated-innate-immune-reactions-against-metastrongyloid-parasites
#2
Felipe Penagos-Tabares, Malin K Lange, Anika Seipp, Ulrich Gärtner, Helena Mejer, Anja Taubert, Carlos Hermosilla
The anthropozoonotic metastrongyloid nematodes Angiostrongylus cantonensis and Angiostrongylus costaricensis, as well as Angiostrongylus vasorum, Crenosoma vulpis, Aelurostrongylus abstrusus and Troglostrongylus brevior are currently considered as emerging gastropod-borne parasites and have gained growing scientific attention in the last years. However, the knowledge on invertebrate immune responses and on how metastrongyloid larvae are attacked by gastropod immune cells is still limited. This work aims to describe an in vitro system to investigate haemocyte-derived innate immune responses of terrestrial gastropods induced by vital axenic metastrongyloid larvae...
April 2018: Parasitology Research
https://www.readbyqxmd.com/read/29386168/-effects-of-lameness-at-the-time-of-drying-off-on-the-lactation-and-fertility-performance-of-the-following-lactation
#3
M Hässig, C Degen Aguayo Aparicio, K Nuss
The aim of the study was to clarify how lameness and its severity in dairy cows at the time of drying off will affect the milk performance and fertility in the following lactation when treated appropriately at the time of drying off. The lameness scoring and a gait assessment took place during drying off, in the 1st week after calving, as well as 2 months after calving. Each lame cow was compared with a non-lame control cow from the same farm. The milk and fertility data of the following lactation were compared with those of the previous lactation...
February 2018: Schweizer Archiv Für Tierheilkunde
https://www.readbyqxmd.com/read/29386167/-correlation-of-a-lameness-scoring-system-and-claw-lesion
#4
M Hässig, C Degen Aguayo Aparicio, K Nuss
The aim of this study was to investigate the relationship between lameness scoring and clinical findings. The lameness scoring and a gait assessment took place during drying off, the first week after calving and two months after calving in 29 lame and 27 free of lameness cows. In between the farmer scored the lamness. Most of the lameness occurred in the hind limbs and were most frequently caused by dermatitis digitalis, Mortellaro, Limax, and Rusterholz sole ulcer. The mean duration of lameness after treatment was 26 days (median 16 days) and was significantly longer in case of horn lesions than in skin lesions (including interdigital dermatitis)...
February 2018: Schweizer Archiv Für Tierheilkunde
https://www.readbyqxmd.com/read/29382276/the-predictive-value-of-the-maximal-liver-function-capacity-test-for-the-isolation-of-primary-human-hepatocytes
#5
Rebeka D Major, Martin Kluge, Maximilian Jara, Maximilian Nösser, Rosa Horner, Joseph Gassner, Benjamin Struecker, Peter Tang, Steffen Lippert, Anja Reutzel-Selke, Dominik Geisel, Timm Denecke, Martin Stockmann, Johann Pratschke, Igor M Sauer, Nathanael Raschzok
The need for primary human hepatocytes is constantly growing for basic research, as well as for therapeutic applications. However, the isolation outcome strongly depends on the quality of liver tissue, and we are still lacking a preoperative test that allows the prediction of the hepatocyte isolation outcome. In this study, we evaluated the "maximal liver function capacity test" (LiMAx) as predictive test for the quantitative and qualitative outcome of hepatocyte isolation. This test is already used in clinical routine to measure preoperative and to predict postoperative liver function...
March 2018: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/29326811/impact-of-liver-volume-and-liver-function-on-posthepatectomy-liver-failure-after-portal-vein-embolization-a-multivariable-cohort-analysis
#6
Patrick H Alizai, Annabel Haelsig, Philipp Bruners, Florian Ulmer, Christian D Klink, Cornelis H C Dejong, Ulf P Neumann, Maximilian Schmeding
Background: Liver failure remains a life-threatening complication after liver resection, and is difficult to predict preoperatively. This retrospective cohort study evaluated different preoperative factors in regard to their impact on posthepatectomy liver failure (PHLF) after extended liver resection and previous portal vein embolization (PVE). Methods: Patient characteristics, liver function and liver volumes of patients undergoing PVE and subsequent liver resection were analyzed...
January 2018: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/29219042/context-dependent-passive-avoidance-learning-in-the-terrestrial-slug-limax
#7
Yuko Fujisaki, Ryota Matsuo
The terrestrial slug Limax has been used as a model animal for studying the neural mechanisms underlying associative olfactory learning. The slug also innately exhibits negative phototactic behavior using its eyes. In the present study, we developed an experimental paradigm for quantification of slug's negative phototaxis behavior, and investigated whether the nature of the negative phototaxis can be modified by learning experience. The experimental set-up consists of light and dark compartments, between which the slug can move freely...
December 2017: Zoological Science
https://www.readbyqxmd.com/read/29156356/limax-extract-ameliorates-cigarette-smoke-induced-chronic-obstructive-pulmonary-disease-in-mice
#8
Xue Liang, Jian Wang, Ruijuan Guan, Li Zhao, Defu Li, Zhen Long, Qian Yang, Jingyi Xu, Ziyi Wang, Jinkui Xie, Wenju Lu
Chronic obstructive pulmonary disease (COPD) is a chronic, progressive and lethal lung disease with few treatments. Limax, a mollusk with lung, has been widely used to control phlegm and cough in China, yet whether Limax has a positive effect on COPD is unknown. This study investigated the effects of water-soluble extract from Limax on COPD development and the underlying mechanisms. The results showed that Limax extract improved lung function, relieved emphysema and suppressed the inflammation in the lungs of CS-challenged mice, as evidenced by diminished release of IL-6, KC, TNF-α, IFN-γ, Muc5AC, IL-17 and diminished mRNA expression of Muc5B...
January 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/28885204/quantitative-evaluation-of-real-time-maximum-liver-capacity-limax-and-time-intensity-curve-tic-analysis-in-ceus-based-microperfusion
#9
M Haimerl, K Brünn, S Poelsterl, L P Beyer, I Wiesinger, C Stroszczynski, E-M Jung, P Wiggermann
PURPOSE: To compare the diagnostic performance of real-time maximum liver capacity (LiMAx) with dynamic contrast-enhanced ultrasound (CEUS)-based liver microcirculation. MATERIALS AND METHODS: 23 patients underwent liver function capacity (LiMAx) test and consecutive or previous CEUS examinations. A bolus injection of 1.4 ml sulfur hexafluoride microbubbles was administered for CEUS measurements (1-6 MHz) and quantitative perfusion analysis (TIC) was performed with an integrated perfusion software using stored cine-loops...
2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28844397/functional-considerations-in-alpps-consequences-for-clinical-management
#10
Martin Stockmann, Jan Bednarsch, Maciej Malinowski, Elisabeth Blüthner, Johann Pratschke, Daniel Seehofer, Maximilian Jara
BACKGROUND: Since perioperative morbidity and mortality in ALPPS are extraordinarily high, a deeper understanding of actual liver function during the procedure is essential to make the approach safer. METHODS: Data from 17 patients who underwent ALLPS were analyzed regarding their course of liver function capacity assessed with the LiMAx test and compared to an equal-sized matched cohort of patients that underwent PVE. RESULTS: A comparison of LiMAx prior to and following ALPPS Step I (330 [258-385] vs...
November 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28841541/use-of-the-liver-maximum-function-capacity-test-limax-for-the-management-of-liver-resection-in-cirrhosis-a-case-of-hypopharyngeal-cancer-liver-metastasis
#11
S Cammann, F Oldhafer, K I Ringe, W Ramackers, K Timrott, M Kleine, J Klempnauer, F Lehner, H Bektas, F W R Vondran
INTRODUCTION: The presence of liver cirrhosis goes along with a higher chance for the need of liver resection. As established laboratory parameters often underestimate the degree of cirrhosis this is associated with an increased risk for postoperative liver failure due to the preoperatively impaired liver function. Known liver function tests are unlikely to be performed in daily use because of high cost or expenditure of time. Liver maximum function capacity test (LiMAx) provides a novel tool for measurement of liver function and references for the safety of liver resection...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28840295/liver-function-quantified-by-limax-test-after-major-abdominal-surgery-comparison-between-open-and-laparoscopic-approach
#12
Magnus Kaffarnik, Gabriel Stoeger, Julia Liebich, Christian Grieser, Johann Pratschke, Martin Stockmann
INTRODUCTION: Major abdominal surgery may lead to a systemic inflammatory response (SIRS) with a risk of organ failure. One possible trigger for a postoperative hepatic dysfunction is an altered hepatic blood flow during SIRS, resulting in a decreased oxygen delivery. This pilot study investigated the role of liver dysfunction measured by the LiMAx test after major abdominal surgery, focussing on open and laparoscopic surgical approaches. METHODS: We prospectively investigated 25 patients (7 females and 18 males, age range 55-72 years) scheduled for upper abdominal surgery...
February 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/28742055/kinetic-validation-of-the-limax-test-during-10-000-intravenous-13-c-methacetin-breath-tests
#13
Tom Moses Rubin, Karsten Heyne, Axel Luchterhand, Jan Bednarsch, Florian W R Vondran, Georgios Polychronidis, Maciej Malinowski, Alen Nikolic, Hans-Michael Tautenhahn, Maximilian Jara, Tilo Wünsch, Martin Stockmann, Johan Friso Lock
The maximal liver function capacity (LiMAx) test, a novel13 C-methacetin breath test, has proven clinical validity in determining hepatic metabolic capacity. In contrast to prior13 C-methacetin breath test protocols, the LiMAx test is performed by intravenous body-weight-adjusted substrate administration. Furthermore, the DOB kinetics (delta over baseline of the time-dependent exhaled13 CO2 /12 CO2 ratio) are measured online at the bedside with a high time resolution in order to determine the maximum DOB. The aim of this study was to analyze the recorded DOB kinetics in a large population for further refinement of the test protocol...
November 29, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28717946/spontaneous-shedding-of-metastrongyloid-third-stage-larvae-by-experimentally-infected-limax-maximus
#14
Gary Conboy, Nicole Guselle, Roland Schaper
No abstract text is available yet for this article.
August 2017: Parasitology Research
https://www.readbyqxmd.com/read/28711678/linezolid-in-liver-failure-exploring-the-value-of-the-maximal-liver-function-capacity-limax-test-in-a-pharmacokinetic-pilot-study
#15
Sebastian G Wicha, Otto R Frey, Anka C Roehr, Johann Pratschke, Martin Stockmann, Rawan Alraish, Tilo Wuensch, Magnus Kaffarnik
Patients in the intensive care unit frequently require antibiotic treatment. Liver impairment poses substantial challenges for dose selection in these patients. The aim of the present pilot study was to assess the novel maximal liver function capacity (LiMAx test) in comparison with conventional liver function markers as covariates of drug clearance in liver failure using linezolid as a model drug. A total of 28 patients with different degrees of liver failure were recruited. LiMAx test as well as plasma, dialysate and urine sampling were performed under linezolid steady-state therapy (600 mg twice daily)...
October 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28687596/expression-and-light-dependent-translocation-of-%C3%AE-arrestin-in-the-visual-system-of-the-terrestrial-slug-limax-valentianus
#16
Ryota Matsuo, Yuka Takatori, Shun Hamada, Mitsumasa Koyanagi, Yuko Matsuo
Vertebrates, cephalopods, and arthropods are equipped with eyes having the highest spatiotemporal resolution among the animal phyla. In parallel, it is only the animals in these three phyla that have visual arrestin specialized for the termination of visual signaling triggered by opsin, in addition to ubiquitously expressed β-arrestin that serves in terminating general G protein-coupled receptor signaling. Indeed, visual arrestin in Drosophila and rodents translocates to the opsin-rich subcellular region in response to light to reduce the overall sensitivity of photoreceptors in an illuminated environment (i...
July 7, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28615470/identification-of-group-b-streptococcus-capsule-type-by-use-of-a-dual-phenotypic-genotypic-assay
#17
Areej Alhhazmi, Armaan Pandey, Gregory J Tyrrell
The group B streptococcus (GBS) capsular polysaccharide (CPS) is an important virulence factor which is also used for GBS typing. There are 10 CPS types (Ia, Ib, and II to IX). GBS that do not phenotypically type are considered nontypeable. All genes required for CPS synthesis are found on the GBS cps operon, which contains a highly variable CPS-determining region ( cpsG-cpsK ). The objective of this study was development of an assay to detect sialic acid on the GBS cell surface, followed by a genotypic PCR CPS typing assay...
September 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28542386/correlation-between-plasma-endothelin-1-levels-and-severity-of-septic-liver-failure-quantified-by-maximal-liver-function-capacity-limax-test-a-prospective-study
#18
Magnus F Kaffarnik, Navid Ahmadi, Johan F Lock, Tilo Wuensch, Johann Pratschke, Martin Stockmann, Maciej Malinowski
AIM: To investigate the relationship between the degree of liver dysfunction, quantified by maximal liver function capacity (LiMAx test) and endothelin-1, TNF-α and IL-6 in septic surgical patients. METHODS: 28 septic patients (8 female, 20 male, age range 35-80y) were prospectively investigated on a surgical intensive care unit. Liver function, defined by LiMAx test, and measurements of plasma levels of endothelin-1, TNF-α and IL-6 were carried out within the first 24 hours after onset of septic symptoms, followed by day 2, 5 and 10...
2017: PloS One
https://www.readbyqxmd.com/read/28516292/limax-test-improves-diagnosis-of-chemotherapy-associated-liver-injury-before-resection-of-colorectal-liver-metastases
#19
Johan F Lock, Tilman Westphal, Tom Rubin, Maciej Malinowski, Antje Schulz, Maximilian Jara, Jan Bednarsch, Martin Stockmann
BACKGROUND: Chemotherapy of colorectal liver metastases (CLMs) prior to liver resection implies the risk of chemotherapy-associated liver injury, leading to increased postoperative morbidity and mortality OBJECTIVE: The aim of this study was to evaluate the LiMAx (liver maximum capacity) test for diagnosis of chemotherapy-associated liver injury. METHODS: This was a retrospective analysis of patients with CLMs, prior to liver resection. We performed preoperative assessment of liver function using biochemical parameters and the LiMAx test...
September 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28293872/effect-of-high-laser-output-on-the-central-bronchi-and-pulmonary-artery
#20
A Kirschbaum, P Rexin, D K Bartsch, K Quint
A diode-pump Nd:YAG high-power laser (wavelength 1320 nm, power 100 W) is routinely used to surgically remove lung metastases. Even pulmonary lesions in central locations are resectable via this method, yet it also carries a potential risk of damaging the larger bronchi and vessels in the vicinity. Studies investigating the safety of using high-power lasers are lacking. We therefore aimed to examine the direct effects of a 100-watt laser on the bronchi and pulmonary artery at a standard working velocity. From freshly slaughtered pigs, we isolated cylindrical specimens of the trachea, the main and lobar bronchi, and the central pulmonary artery from the both lungs...
May 2017: Lasers in Medical Science
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