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Satoshi Watanabe, Moritoshi Hirono
Oscillatory neural activities have been implicated in various types of information processing in the CNS. The procerebral (PC) lobe of the land mollusk Limax valentianus shows an ongoing oscillatory local field potential (LFP). Olfactory input increases both the frequency and spatial synchrony of the LFP oscillation by a nitric oxide (NO)-mediated mechanism, but how NO modulates the activity in a specific manner has been unclear. In the present study, we used electrical stimulation and NO uncaging to systematically analyze the response of the LFP oscillation and found phase-dependent effects on phase shifting and synchrony...
September 2016: ENeuro
Nathanael Raschzok, Eckart Schott, Anja Reutzel-Selke, Iman Damrah, Safak Gül-Klein, Benjamin Strücker, Igor Maximilian Sauer, Johann Pratschke, Dennis Eurich, Martin Stockmann
BACKGROUND: The new directly acting antivirals (DAAs) enable all-oral interferon-free treatment of chronic hepatitis C virus (HCV) infection. We here investigated the effect of DAAs on the enzymatic liver function of liver transplant recipients with recurrent hepatitis C. METHODS: Twenty-one patients with elevated liver enzymes or advanced fibrosis/compensated cirrhosis caused by recurrent HCV were treated with sofosbuvir either in combination with simeprevir, or in combination with ribavirin or daclatasvir with or without ribavirin for 12 weeks...
December 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
Yuko Suenaga, Ryota Matsuo
The terrestrial slug Limax can form an odor-aversion memory by the single simultaneous presentation of a food odor and an aversive stimulus. We have previously demonstrated that the long-term retention of this memory was impaired by a high-dose injection of a protein synthesis inhibitor 30min prior to the conditioning. However, the onset of amnesia was delayed if the dose of the inhibitor was reduced or a less potent protein synthesis inhibitor was used. We thus speculated that the persistence of memory depends on the amount of newly synthesized protein following learning...
September 6, 2016: Neuroscience Letters
Felix Oldhafer, Kristina I Ringe, Kai Timrott, Moritz Kleine, Wolf Ramackers, Sebastian Cammann, Mark D Jäger, Juergen Klempnauer, Hueseyin Bektas, Florian W R Vondran
BACKGROUND: The two-stage liver resection combining in situ liver transection with portal vein ligation, also referred to as ALPPS (Associating Liver Partition and Portal vein ligation for Staged hepatectomy), has been described as a promising method to increase the resectability of liver tumors. However, one of the most important issues regarding the safety of this procedure is the optimal timing of the second stage at the point of sufficient hypertrophy of the future liver remnant. The recently developed liver maximum function capacity test (LiMAx) can be applied to monitor the liver function postoperatively and hence could be a useful tool for decision-making regarding the timing of the second stage of ALPPS...
2016: Patient Safety in Surgery
Florian Wolfgang Rudolf Vondran, Carsten Schumacher, Kai Johanning, Björn Hartleben, Wolfgang Knitsch, Olaf Wiesner, Elmar Jaeckel, Michael Peter Manns, Juergen Klempnauer, Hueseyin Bektas, Frank Lehner
Background. Despite aggressive intensive medical management acute liver failure (ALF) may require high-urgency liver transplantation (LTx). Available prognostic scores do not apply for all patients; reliable tools to identify individuals in need of LTx are highly required. The liver maximum function capacity test (LiMAx) might represent an appropriate option. Referring to a case of ALF after Amanita phalloides-intoxication the potential of the LiMAx-test in this setting is discussed. Presentation of Case. LiMAx was performed in a 27-year-old patient prior to and after high-urgency LTx...
2016: Case Reports in Transplantation
Ryota Matsuo, Marin Tanaka, Rena Fukata, Suguru Kobayashi, Hitoshi Aonuma, Yuko Matsuo
The terrestrial slug Limax can learn to avoid the odor of some food (e.g. carrot juice) by the simultaneous presentation of an aversive stimulus (e.g. bitterness of quinidine). This type of associative memory critically depends on the higher olfactory center, the procerebrum in the central nervous system. The modulation of the local field potential (LFP) oscillation recorded on the procerebrum has been thought to reflect the information processing of the odor that elicits the behavioral change, such as avoidance of the aversively learned odor or approaching an attractive food's odor...
May 17, 2016: Journal of Comparative Neurology
Jan Bednarsch, Elisabeth Blüthner, Maciej Malinowski, Daniel Seehofer, Johann Pratschke, Martin Stockmann
BACKGROUND: Postoperative bile leakage (PBL) is a major surgical complication after partial liver resection resulting in increased perioperative morbidity and mortality. Previous experimental studies have shown an adverse effect on functional liver regeneration, but there are still no data available concerning these effects in humans. MATERIALS AND METHODS: A retrospective matched pair analysis was carried out comparing the postoperative course of 51 patients with PBL to 51 patients without PBL...
September 2016: World Journal of Surgery
Yurika Koga, Yuko Matsuo, Ryota Matsuo
Terrestrial pulmonates can form odor-aversion memories once a food odor is presented in combination with an aversive stimulus. Most of the olfactory information ascends via a tentacular ganglion located in the tip of the two pairs of tentacles, and is then transmitted to the higher olfactory center, the procerebrum. The procerebrum is the locus of memory storage and has been shown to be necessary for odor-aversion learning. However, it is unknown whether the procerebrum is the sole locus in which the memory engram resides...
February 2016: Zoological Science
Andreas Kirschbaum, Christian Meyer, Detlef K Bartsch
No abstract text is available yet for this article.
December 16, 2015: Journal of Cardiothoracic Surgery
Andreas Kirschbaum, Peter Rexin, Anja Rinke, Detlef K Bartsch
No abstract text is available yet for this article.
December 16, 2015: Journal of Cardiothoracic Surgery
Maciej Malinowski, Johan Friso Lock, Daniel Seehofer, Bernhard Gebauer, Antje Schulz, Lina Demirel, Jan Bednarsch, Victoria Stary, Peter Neuhaus, Martin Stockmann
PURPOSE: Post-hepatectomy liver failure (PHLF) is the major risk factor for mortality after hepatectomy. Preoperative planning of the future liver remnant volume reduces PHLF rates; however, future liver remnant function (FLR-F) might have an even stronger predictive value. In this preliminary study, we used a new method to calculate FLR-F by the LiMAx test and computer tomography-assisted volumetric-analysis to visualize liver function changes after portal vein embolization (PVE) before extended hepatectomy...
September 2016: Surgery Today
Jan Bednarsch, Mario Menk, Maciej Malinowski, Steffen Weber-Carstens, Johann Pratschke, Martin Stockmann
Temporary extracorporeal membrane oxygenation (ECMO) has been established as an essential part of therapy in patients with pulmonary or cardiac failure. As physiological gaseous exchange is artificially altered in this patient group, it is debatable whether a (13) C-breath test can be carried out. In this proof of technical feasibility report, we assess the viability of the (13) C-breath test LiMAx (maximum liver function capacity) in patients on ECMO therapy. All breath probes for the test device were obtained directly via the membrane oxygenator...
July 2016: Artificial Organs
Maximilian Jara, Jan Bednarsch, Maciej Malinowski, Johann Pratschke, Martin Stockmann
PURPOSE: Chemotherapy-associated liver injury of patients undergoing therapy for colorectal liver metastases stimulates concerns on surgical safety. No common guidelines for the optimal timing of liver surgery after the application of systemic chemotherapy (chemotherapy-free interval) have been established and effects on individual liver function remain unexplored. METHODS: Maximum liver function capacity (LiMAx) and indocyanine green plasma disappearance rate (ICG-PDR) were measured in 20 patients with colorectal cancer receiving adjuvant oxaliplatin-based chemotherapy (OBC) prior to the first and after the last treatment course as well as 4 and 8 weeks thereafter...
February 2016: Langenbeck's Archives of Surgery
Satoshi Watanabe, Fumihito Takanashi, Kohei Ishida, Suguru Kobayashi, Yoshiichiro Kitamura, Yuuta Hamasaki, Minoru Saito
Nitric oxide (NO) modulates the dynamics of central olfactory networks and has been implicated in olfactory processing including learning. Land mollusks have a specialized olfactory lobe in the brain called the procerebral (PC) lobe. The PC lobe produces ongoing local field potential (LFP) oscillation, which is modulated by olfactory stimulation. We hypothesized that NO should be released in the PC lobe in response to olfactory stimulation, and to prove this, we applied an NO electrode to the PC lobe of the land slug Limax in an isolated tentacle-brain preparation...
2015: PloS One
Mohammad Reza Mahmoudi, Behnaz Rahmati, Seyed Hosssen Seyedpour, Panagiotis Karanis
This study was conducted to determine the presence and molecular identity of Acanthamoeba species in the surface water resources of four provinces in Iran, namely Guilan, Mazandaran (North of Iran), Alborz, and Tehran (capital city), using culture- and molecular-based methods. During March to November 2014, 49 surface water samples were collected from environmental water sources-the distinct surface waters of Guilan, Mazandaran, Alborz, and Tehran provinces, in Iran. For the isolation of Acanthamoeba species, approximately 500 ml of the water samples were filtered through a cellulose nitrate membrane with a pore size of 0...
December 2015: Parasitology Research
D Geisel, L Lüdemann, B Hamm, T Denecke
UNLABELLED: Preoperative assessment of liver function and prediction of postoperative functional reserve are important in patients scheduled for liver resection. While determination of absolute liver function currently mostly relies on laboratory tests and clinical scores, postoperative remnant liver function is estimated volumetrically using imaging data obtained with computed tomography (CT) or magnetic resonance imaging (MRI). Accurate estimation of hepatic function is also relevant for intensive care patients, oncologic patients, and patients with diffuse liver disease...
October 2015: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
Ryota Matsuo, Rena Fukata, Moeko Kumagai, Asuka Kobayashi, Suguru Kobayashi, Yuko Matsuo
Terrestrial mollusks can form an odor aversion memory following the simultaneous presentation of a food odor and an aversive stimulus. The local field potential oscillation recorded on the surface of the procerebrum (PC; the higher olfactory center) exhibits a frequency change in response to the detection of a learned odor; such a change is thus considered to reflect the internal state of the brain during memory recall. Thus far, dopamine and serotonin have been demonstrated to change the oscillatory frequency...
January 1, 2016: Journal of Comparative Neurology
Maximilian Jara, Tim Reese, Maciej Malinowski, Erika Valle, Daniel Seehofer, Gero Puhl, Peter Neuhaus, Johann Pratschke, Martin Stockmann
OBJECTIVES: Post-hepatectomy liver failure has a major impact on patient outcome. This study aims to explore the impact of the integration of a novel patient-centred evaluation, the LiMAx algorithm, on perioperative patient outcome after hepatectomy. METHODS: Trends in perioperative variables and morbidity and mortality rates in 1170 consecutive patients undergoing elective hepatectomy between January 2006 and December 2011 were analysed retrospectively. Propensity score matching was used to compare the effects on morbidity and mortality of the integration of the LiMAx algorithm into clinical practice...
July 2015: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Alexander S Berezin, Yury A Skorik
Novel water-soluble chitosan-isoniazid conjugates were synthesized by two methods: (1) the carbodiimide method using isoniazid (INH) and N-(2-carboxyethyl)chitosan (CEC), and (2) the reaction between INH and N-(3-chloro-2-hydroxypropyl)chitosan (CHPC). The solubility of the conjugates under physiological conditions was enhanced by phosphorylation. Method (1) is preferable in terms of obtaining conjugates with a high content of active substance; depending on reaction conditions, the degree of substitution in the INH-CEC conjugates varies from 0...
August 20, 2015: Carbohydrate Polymers
Yun-hai Guo, Shan Lv, Wen-biao Gu, He-xiang Liu, Ying Wu, Yi Zhang
OBJECTIVE: To investigate the species distribution and infection status of host snails of Angiostongylus cantonensis in Shanghai. METHODS: From August 2012 to October 2014, 10 districts or counties were selected for this investigation in Shanghai, including Jiading, Qingpu, Putuo, Baoshan, Yangpu, Minhang, Songjiang, Jinshan, Chongming, and Pudong. All of the snails were examined by lung-microscopy and tissue homogenate methods. RESULTS: Totally 1074 snail samples were identified, belonging to 8 families, 10 species, including Pomacea canaliculata (133), Achatina fulica (25), Cipangopaludina chinensis (183), Bellamya aeruginosa (78), Physa acuta (349), Radix swinhoei (224), Bradybaena similaris (45), B...
December 2014: chinese Journal of Parasitology & Parasitic Diseases
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