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https://www.readbyqxmd.com/read/27898749/-dosimetric-comparison-of-different-techniques-for-external-beam-accelerated-partial-breast-irradiation
#1
Gábor Stelczer, Tibor Major, Norbert Mészáros, Csaba Polgár, Csilla Pesznyák
The aim of this article is to evaluate and compare four different radiotherapy techniques of accelerated partial breast irradiation (APBI) considering planning quality, dosimetric and practical aspects. The investigated techniques are three dimensional conformal radiotherapy (3D-CRT), "step and shoot" (SS) and "sliding window" (SW) intensity-modulated radiotherapy, intensity-modulated arc therapy (RA). CT scans of 10 patients previously treated with APBI were selected for the study. Surgical clips were placed on the borders of the tumour bed during breast conserving surgery...
November 29, 2016: Magyar Onkologia
https://www.readbyqxmd.com/read/27872946/implementation-of-image-guided-intensity-modulated-accelerated-partial-breast-irradiation-three-year-results-of-a%C3%A2-phase%C3%A2-ii-clinical-study
#2
Norbert Mészáros, Tibor Major, Gábor Stelczer, Zoltán Zaka, Emőke Mózsa, Dávid Pukancsik, Zoltán Takácsi-Nagy, János Fodor, Csaba Polgár
PURPOSE: To report 3‑year results of accelerated partial breast irradiation (APBI) using image-guided intensity-modulated radiotherapy (IG-IMRT) following breast conserving surgery (BCS) for low-risk early invasive breast cancer. PATIENTS AND METHODS: Between July 2011 and March 2014, 60 patients with low-risk early invasive breast cancer underwent BCS and were enrolled in this phase II prospective study. The total dose was 36.9 Gy (9 fractions of 4.1 Gy, two fractions/day)...
November 21, 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/27869081/long-term-update-of-nrg-oncology-rtog-0319-a-phase-1-and-2%C3%A2-trial-to-evaluate-3-dimensional-conformal-radiation-therapy-confined-to-the-region-of%C3%A2-the%C3%A2-lumpectomy-cavity-for-stage-i-and-ii-breast%C3%A2-carcinoma
#3
Rachel Rabinovitch, Jennifer Moughan, Frank Vicini, Helen Pass, John Wong, Susan Chafe, Ivy Petersen, Douglas W Arthur, Julia White
PURPOSE: NRG Oncology RTOG 0319 was the first cooperative group trial in the United States to evaluate 3-dimensional conformal radiation therapy (3D-CRT) accelerated partial breast irradiation (APBI). This report updates secondary endpoints of toxicity and efficacy. METHODS AND MATERIALS: Patients with stage I or II invasive breast cancer (tumor size ≤3 cm, ≤3 positive lymph nodes, negative margins) were eligible for 3D-CRT APBI: 38.5 Gy in 10 twice-daily fractions...
December 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27837457/external-radiotherapy-for-breast-cancer-in-the-elderly
#4
REVIEW
Francesca Maria Giugliano, Sara Falivene, Emanuela Esposito, Rossella Di Franco, Matteo Muto, Massimiliano D'Aiuto, Paolo Muto
BACKGROUND: Breast cancer is the most common malignancy amongst elderly women and the main cause of mortality. A specific management for elderly woman is not clear because clinical trials are usually not customized for this subset of patients. AIMS: The aim of this paper is to provide an overview of the available information on the main issues in the field of breast cancer radiotherapy in the elderly population. MATERIALS AND METHODS: Authors discuss on different radiation treatments for breast cancer in the elderly, based on the data of the literature with a focus on new strategy: hypo-fractionation, accelerated partial breast irradiation, and the utility of a dose boost...
November 11, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27803959/accelerated-partial-breast-irradiation-with-external-beam-radiotherapy-first-results-of-the-german-phase%C3%A2-2-trial
#5
Oliver J Ott, Vratislav Strnad, Wilhelm Stillkrieg, Wolfgang Uter, Matthias W Beckmann, Rainer Fietkau
BACKGROUND AND PURPOSE: To evaluate the feasibility and efficacy of external beam three-dimensional (3D) conformal accelerated partial breast irradiation (APBI) for selected patients with early breast cancer. PATIENTS AND METHODS: Between 2011 and 2016, 72 patients were recruited for this prospective phase 2 trial. Patients were eligible for APBI if they had histologically confirmed breast cancer or pure ductal carcinoma in situ (DCIS), a tumor diameter ≤3 cm, clear resection margins ≥2 mm, no axillary lymph node involvement, no distant metastases, tumor bed clips, and were aged ≥50 years...
November 1, 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/27788951/magnetic-resonance-image-guided-radiation-therapy-for-external-beam-accelerated-partial-breast-irradiation-evaluation-of-delivered-dose-and-intrafractional-cavity-motion
#6
Sahaja Acharya, Benjamin W Fischer-Valuck, Thomas R Mazur, Austen Curcuru, Karl Sona, Rojano Kashani, Olga Green, Laura Ochoa, Sasa Mutic, Imran Zoberi, H Harold Li, Maria A Thomas
PURPOSE: To use magnetic resonance image guided radiation therapy (MR-IGRT) for accelerated partial-breast irradiation (APBI) to (1) determine intrafractional motion of the breast surgical cavity; and (2) assess delivered dose versus planned dose. METHODS AND MATERIALS: Thirty women with breast cancer (stages 0-I) who underwent breast-conserving surgery were enrolled in a prospective registry evaluating APBI using a 0.35-T MR-IGRT system. Clinical target volume was defined as the surgical cavity plus a 1-cm margin (excluding chest wall, pectoral muscles, and 5 mm from skin)...
November 15, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27777879/accelerated-partial-breast-irradiation-past-present-and-future
#7
Anne W Tann, Sandra S Hatch, Melissa M Joyner, Lee R Wiederhold, Todd A Swanson
Accelerated partial breast irradiation (APBI) focuses higher doses of radiation during a shorter interval to the lumpectomy cavity, in the setting of breast conserving therapy for early stage breast cancer. The utilization of APBI has increased in the past decade because of the shorter treatment schedule and a growing body of outcome data showing positive cosmetic outcomes and high local control rates in selected patients undergoing breast conserving therapy. Technological advances in various APBI modalities, including intracavitary and interstitial brachytherapy, intraoperative radiation therapy, and external beam radiation therapy, have made APBI more accessible in the community...
October 10, 2016: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27675232/dosimetric-comparison-of-robotic-imrt-and-partial-arc-vmat-in-accelerated-partial-breast-irradiation-apbi-for-early-breast-cancer
#8
S Y Kim, J H Kim, J Y Woo, J G Baek, K S Park, M J Kim, J H Cho
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674935/discrepancies-in-accelerated-partial-breast-irradiation-apbi-treatment-outcomes-in-younger-women-when-using-claims-versus-a-database-promis-with-actual-recurrence-rates
#9
R R Kuske, J Demanes, B M Anderson, P Y Chen, J K Hayes, C A Quiet, J Wang, D Veruttipong, M Kamrava
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674723/five-year-outcomes-of-accelerated-partial-breast-irradiation-apbi-from-a-large-community-based-practice
#10
N A Madden, J Buckner, I Abdalla
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27672743/outcomes-of-node-positive-breast-cancer-patients-treated-with-accelerated-partial-breast-irradiation-via-multicatheter-interstitial-brachytherapy-the-pooled-registry-of-multicatheter-interstitial-sites-promis-experience
#11
Mitchell Kamrava, Robert R Kuske, Bethany Anderson, Peter Chen, John Hayes, Coral Quiet, Pin-Chieh Wang, Darlene Veruttipong, Margaret Snyder, David J Demanes
OBJECTIVES: To report outcomes for breast-conserving therapy using adjuvant accelerated partial breast irradiation (APBI) with interstitial multicatheter brachytherapy in node-positive compared with node-negative patients. MATERIALS AND METHODS: From 1992 to 2013, 1351 patients (1369 breast cancers) were treated with breast-conserving surgery and adjuvant APBI using interstitial multicatheter brachytherapy. A total of 907 patients (835 node negative, 59 N1a, and 13 N1mic) had >1 year of data available and nodal status information and are the subject of this analysis...
September 26, 2016: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27666436/outcomes-according-to-breast-cancer-subtype-in-patients-treated-with-accelerated-partial-breast-irradiation
#12
J Ben Wilkinson, Chirag Shah, Mitual Amin, Laura Nadeau, Simona F Shaitelman, Peter Y Chen, Inga S Grills, Alvaro A Martinez, Christina K Mitchell, Michelle F Wallace, Frank A Vicini
BACKGROUND: The purpose of the study was to determine outcomes for patients treated with accelerated partial breast irradiation (APBI) on the basis of breast cancer subtype (BCST). PATIENTS AND METHODS: Our single-institution, institutional review board-approved APBI database was queried for patients who had complete testing results for the estrogen (ER), progesterone (PR), and HER2/neu receptors to determine outcomes for each BCST. Women were assigned as luminal A (LA), luminal B (LB), HER2, and basal BCST using their ER, PR, and HER2/neu receptor status...
July 28, 2016: Clinical Breast Cancer
https://www.readbyqxmd.com/read/27660474/accelerated-partial-breast-irradiation-in-an-asian-population-dosimetric-findings-and-preliminary-results-of-a-multicatheter-interstitial-program
#13
Yaling Vicky Koh, Poh Wee Tan, Shaik Ahmad Buhari, Philip Iau, Ching Wan Chan, Liang Shen, Sing Huang Tan, Johann I-Hsiung Tang
INTRODUCTION: Accelerated partial breast irradiation (APBI) using the multicatheter method has excellent cosmesis and low rates of long-term toxicity. However, there are few studies looking at the feasibility of this procedure and the outcomes in an Asian population. This study aims to look at outcomes at our hospital. METHODS: We identified 121 patients treated with APBI at our center between 2008 and 2014. The median follow-up for our patient group was 30 months (range 3...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27648085/modelling-the-radiobiological-effect-of-intraoperative-x-ray-brachytherapy-for-breast-cancer-using-an-air-filled-spherical-applicator
#14
Kris Armoogum, Simon Evans, David Morgan
PURPOSE: We present a framework, in which we compare a conventional standard dose of 50 Gy in 25 fractions with accelerated partial breast irradiation (APBI) using electronic brachytherapy (eBT). We discuss how radiobiological modelling enables us to establish a framework, within which we can compare external beam radiotherapy (EBRT). This leads to a determination of the shell of isoeffect in breast tissue, at which very low kV eBT can be considered to be clinically equivalent to standard EBRT...
August 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/27635622/evaluating-candidacy-for-hypofractionated-radiation-therapy-accelerated-partial-breast-irradiation-and-endocrine-therapy-after-breast-conserving-surgery-a-surveillance-epidemiology-and-end-results-seer-analysis
#15
Bindu V Manyam, Rahul Tendulkar, Sheen Cherian, Frank Vicini, Shahed N Badiyan, Chirag Shah
PURPOSE/OBJECTIVE(S): After breast conserving surgery, adjuvant radiation therapy represents the standard of care for most patients. However, multiple options exist beyond standard fractionated whole breast irradiation including hypofractionated whole breast irradiation (HFRT), accelerated partial breast irradiation (APBI), and endocrine therapy (ET) alone, which can limit treatment duration, and potentially reduce morbidity and cost. Limited data are available on the percentage of patients eligible for these alternatives; therefore, a Surveillance Epidemiology and End Results (SEER) analysis was performed to assess candidacy for these alternative options in women with early stage breast cancer...
September 15, 2016: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27614660/feasibility-and-full-course-dosimetry-of-an-intraoperatively-placed-multichannel-brachytherapy-catheter-for-accelerated-partial-breast-irradiation
#16
Bradley J Stish, Deanna H Pafundi, Tina J Hieken, Thomas J Whitaker, Keith M Furutani, James W Jakub, Judy C Boughey, Amy C Degnim, Luke B McLemore, Benjamin Mou, Robert W Mutter, Sean S Park
PURPOSE: Determine feasibility and resultant dosimetry of an intraoperatively placed multichannel intracavitary brachytherapy catheter for accelerated partial breast irradiation (APBI). METHODS: Patients with breast cancer underwent intraoperative brachytherapy catheter placement based on frozen section analysis with immediate postoperative APBI. The planning target volume evaluation (PTVEval) and organs at risk were contoured on daily pretreatment CT scans for each patient, and the original treatment plan was applied to assess full-course dosimetry...
September 7, 2016: Brachytherapy
https://www.readbyqxmd.com/read/27614526/-partial-breast-irradiation-technique-with-external-beam-radiation-therapy-and-brachytherapy
#17
M-E Chand-Fouché, D Lam Cham Kee, M Gautier, J-M Hannoun-Levi
Accelerated Partial Breast Irradiation (APBI) appears to be an efficient therapeutic modality provided that it uses strict selection criteria and a reliable and well-managed technique. The techniques that enable to deliver postoperative APBI are interstitial brachytherapy, endocavitary brachytherapy and external beam radiation therapy. Once an appropriate selection of the candidates is made, each radiation technique needs an exact target volume definition and a strict compliance with its own dosimetric constraints...
October 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/27596252/association-between-renin-and-atherosclerotic-burden-in-subjects-with-and-without-type-2-diabetes
#18
Isabel Gonçalves, Andreas Edsfeldt, Helen M Colhoun, Angela C Shore, Carlo Palombo, Andrea Natali, Gunilla Nordin Fredrikson, Harry Björkbacka, Maria Wigren, Eva Bengtsson, Gerd Östling, Kunihiko Aizawa, Francesco Casanova, Margaretha Persson, Kim Gooding, Phil Gates, Faisel Khan, Helen C Looker, Fiona Adams, Jill Belch, Silvia Pinnola, Elena Venturi, Michaela Kozakova, Li-Ming Gan, Volker Schnecke, Jan Nilsson
BACKGROUND: Activation of the renin-angiotensin-aldosterone-system (RAAS) has been proposed to contribute to development of vascular complications in type 2 diabetes (T2D). The aim of the present study was to determine if plasma renin levels are associated with the severity of vascular changes in subjects with and without T2D. METHODS: Renin was analyzed by the Proximity Extension Assay in subjects with (n = 985) and without (n = 515) T2D participating in the SUMMIT (SUrrogate markers for Micro- and Macro-vascular hard endpoints for Innovative diabetes Tools) study and in 205 carotid endarterectomy patients...
2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27552811/assessment-of-dose-variation-for-accelerated-partial-breast-irradiation-using-rigid-and-deformable-image-registrations
#19
Vikneswary Batumalai, Lois Holloway, Amy Walker, Michael Jameson, Geoff P Delaney
PURPOSE: The aim of this study was to estimate the delivered dose to the target and organs at risk (OAR) for external beam accelerated partial-breast irradiation (APBI) accounting for day-to-day setup uncertainties, using rigid and deformable image registration. METHODS AND MATERIALS: One planning computed tomography (CT) scan and 5 cone beam CT scans for each of 25 patients previously treated with tangential breast radiation therapy were used. All cone beam CT scans were registered to the planning CT scan using 3 techniques: (1) rigid registration based on bony anatomy only, (2) rigid registration based on soft-tissue only, and (3) deformable image registration...
June 23, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/27544819/multicatheter-interstitial-brachytherapy-versus-intensity-modulated-external-beam-therapy-for-accelerated-partial-breast-irradiation-a-comparative-treatment-planning-study-with-respect-to-dosimetry-of-organs-at-risk
#20
Tibor Major, Gábor Stelczer, Csilla Pesznyák, Norbert Mészáros, Csaba Polgár
OBJECTIVE: To dosimetrically compare multicatheter interstitial brachytherapy (MIBT) and intensity modulated radiotherapy (IMRT) for accelerated partial breast irradiation (APBI) with special focus on dose to normal tissues and organs at risk (OAR-s). MATERIAL AND METHODS: Thirty-four patients with early stage breast cancer treated with MIBT were selected for the study. For each patient an additional IMRT treatment plan was created using the same CT data and contours as used in MIBT plans...
August 17, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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