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https://www.readbyqxmd.com/read/28474300/uncertainty-of-cosmetic-evaluation-after-accelerated-partial-breast-irradiation-interim-analysis-of-a-japanese-prospective-multi-institutional-feasibility-study
#1
Eisaku Yoden, Takayuki Nose, Yuki Otani, Shuuji Asahi, Iwao Tsukiyama, Takushi Dokiya, Toshiaki Saeki, Ichirou Fukuda, Hiroshi Sekine, Naoto Shikama, Yu Kumazaki, Takao Takahashi, Ken Yoshida, Tadayuki Kotsuma, Norikazu Masuda, Kazutaka Nakashima, Taisei Matsumura, Shino Nakagawa, Seiji Tachiiri, Yoshio Moriguchi, Jun Itami, Masahiko Oguchi
PURPOSE: We conducted a multi-institutional prospective study on accelerated partial breast irradiation (APBI) using interstitial brachytherapy. The clinical results over a minimum follow-up period of 30 months are presented here. MATERIALS AND METHODS: Forty-six patients with breast cancer were treated with breast-conserving surgery and postoperative APBI. After confirmation of negative surgical margins and negative lymph nodes, a high-dose-rate brachytherapy protocol of 36 Gy/6 fractions was carried out...
May 4, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28458578/intraoperative-radiation-therapy-for-breast-cancer-patients-current-perspectives
#2
REVIEW
Sunil W Dutta, Shayna L Showalter, Timothy N Showalter, Bruce Libby, Daniel M Trifiletti
Accelerated partial breast irradiation (APBI) provides an attractive alternative to whole breast irradiation (WBI) through normal tissue radiation exposure and reduced treatment duration. Intraoperative radiation therapy (IORT) is a form of APBI with the shortest time interval, as it delivers the entirety of a planned radiation course at the time of breast surgery. However, faster is not always better, and IORT has been met with healthy skepticism. Patients treated with IORT have an increased compliance and overall satisfaction when compared to patients treated with WBI...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28445590/long-term-radiographic-findings-of-breast-brachytherapy-implications-of-surgical-volume
#3
Audrey S Wallace, Vladislav Tchatalbachev, Jay Nelson, Zhenyu Wang, Paul Dale, Gregory B Biedermann
PURPOSE: Little is known about long-term radiographic findings after treatment with accelerated partial breast irradiation (APBI). METHODS: Univariate and multivariate analysis of factors leading to formation and resolution of seroma were performed in patients treated with lumpectomy and APBI. RESULTS: Post-treatment images of 129 patients were reviewed by one radiologist. Median surgical excision volume was 108.9 cc (range 20.5-681.9). Primary mode of imaging was mammogram...
April 26, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28274398/lower-mean-heart-dose-with-deep-inspiration-breath-hold-whole-breast-irradiation-compared-with-brachytherapy-based-accelerated-partial-breast-irradiation-for-women-with-left-sided-tumors
#4
COMPARATIVE STUDY
Emma B Holliday, Steve M Kirsner, Howard D Thames, Bryan E Mason, Christopher L Nelson, Elizabeth S Bloom
PURPOSE: For left-sided breast cancer, radiation to the heart is a concern. We present a comparison of mean heart and coronary artery biologically effective dose (BED) between accelerated partial breast irradiation (APBI) and whole breast irradiation with deep inspiration breath-hold technique (DIBH-WBI). METHODS AND MATERIALS: A total of 100 patients with left-sided, early-stage breast cancer were identified. Fifty underwent single-entry catheter-based APBI and 50 underwent DIBH-WBI...
March 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28274211/redefining-radiotherapy-for-early-stage-breast-cancer-with-single-dose-ablative-treatment-a-study-protocol
#5
R K Charaghvandi, B van Asselen, M E P Philippens, H M Verkooijen, C H van Gils, P J van Diest, R M Pijnappel, M G G Hobbelink, A J Witkamp, T van Dalen, E van der Wall, T C van Heijst, R Koelemij, M van Vulpen, H J G D van den Bongard
BACKGROUND: A shift towards less burdening and more patient friendly treatments for breast cancer is currently ongoing. In low-risk patients with early-stage disease, accelerated partial breast irradiation (APBI) is an alternative for whole breast irradiation following breast-conserving surgery. MRI-guided single dose ablative APBI has the potential to offer a minimally burdening, non-invasive treatment that could replace current breast-conserving therapy. METHODS: The ABLATIVE study is a prospective, single arm, multicenter study evaluating preoperative, single dose, ablative radiation treatment in patients with early-stage breast cancer...
March 9, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28262584/accelerated-partial-breast-irradiation-using-intensity-modulated-radiotherapy-versus-whole-breast-irradiation-health-related-quality-of-life-final-analysis-from-the-florence-phase-3-trial
#6
Icro Meattini, Calogero Saieva, Guido Miccinesi, Isacco Desideri, Giulio Francolini, Vieri Scotti, Livia Marrazzo, Stefania Pallotta, Fiammetta Meacci, Cristina Muntoni, Benedetta Bendinelli, Luis Jose Sanchez, Marco Bernini, Lorenzo Orzalesi, Jacopo Nori, Simonetta Bianchi, Lorenzo Livi
BACKGROUND: Accelerated partial breast irradiation (APBI) represents a valid option for selected early breast cancer (BC). We recently published the 5-year results of the APBI-IMRT-Florence phase 3 randomised trial (NCT02104895), showing a very low rate of disease failure, with acute and early-late toxicity in favour of APBI. We present the early and 2-year follow-up health-related quality of life (HRQoL) results. METHODS: Eligible patients were women aged more than 40 years with early BC suitable for breast-conserving surgery...
March 2, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28244410/preoperative-accelerated-partial-breast-irradiation-for-early-stage-breast-cancer-preliminary-results-of-a-prospective-phase-2-trial
#7
Elizabeth Nichols, Susan B Kesmodel, Emily Bellavance, Cynthia Drogula, Katherine Tkaczuk, Randi J Cohen, Wendla Citron, Michelle Morgan, Paul Staats, Steven Feigenberg, William F Regine
PURPOSE: To assess the feasibility of utilizing 3-dimensional conformal accelerated partial-breast irradiation (APBI) in the preoperative setting followed by standard breast-conserving therapy. PATIENTS AND METHODS: This was a prospective trial testing the feasibility of preoperative APBI followed by lumpectomy for patients with early-stage invasive ductal breast cancer. Eligible patients had T1-T2 (<3 cm), N0 tumors. Patients received 38.5 Gy in 3.85-Gy fractions delivered twice daily...
March 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28132391/accelerated-partial-breast-irradiation-compared-with-whole-breast-radiation-therapy-a-breast-cancer-cohort-study-measuring-change-in-radiation-side-effects-severity-and-quality-of-life
#8
M Pérez, M Schootman, L E Hall, D B Jeffe
PURPOSE: Radiotherapy (RT) after breast-conserving surgery for early-stage breast cancer patients has similar survival benefits with whole breast RT (WBRT) or accelerated partial breast irradiation (APBI). However, the impact of RT type and side-effects severity on change in quality of life (QOL) is unknown. We examined changes in RT side-effects severity and QOL by RT type. METHODS: We analyzed data from a cohort of 285 newly diagnosed early-stage breast cancer patients with tumor size ≤3...
April 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28115956/whole-breast-irradiation-vs-apbi-using-multicatheter-brachytherapy-in-early-breast-cancer-simulation-of-treatment-costs-based-on-phase-3-trial-data
#9
Aleksandra Harat, Maciej Harat, Roman Makarewicz
PURPOSE: A recent large phase 3 trial demonstrated that the efficacy of accelerated partial-breast irradiation (APBI) in the treatment of early breast cancer is non-inferior to that of whole breast irradiation (WBI) commonly used in this indication. The aim of this study was to compare the costs of treatment with APBI and WBI in a population of patients after conserving surgery for early breast cancer, and to verify if the use of APBI can result in direct savings of a public payer. MATERIAL AND METHODS: The hereby presented cost analysis was based on the results of GEC-ESTRO trial...
December 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28115955/clinical-outcomes-toxicity-and-cosmesis-in-breast-cancer-patients-with-close-skin-spacing-treated-with-accelerated-partial-breast-irradiation-apbi-using-multi-lumen-catheter-applicators
#10
Mani Akhtari, Mirna Abboud, Sean Szeja, Ramiro Pino, Gary D Lewis, Barbara L Bass, Darlene M Miltenburg, E Brian Butler, Bin S Teh
PURPOSE: Accelerated partial breast irradiation (APBI) using a single-lumen device is associated with better cosmetic outcomes if the spacing between the applicator and skin is > 7 mm. However, there are no reports addressing the late toxicity and clinical outcomes in patients treated with single-entry multi-lumen/catheter applicators who had close skin spacing (7 mm or less). We undertook this study to report clinical outcome, acute and late toxicity as well as cosmesis of early stage breast cancer patients with close skin spacing treated with APBI using multi-lumen or multi-catheter devices...
December 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28114948/current-controversies-in-radiotherapy-for-breast-cancer
#11
REVIEW
David Krug, René Baumann, Wilfried Budach, Jürgen Dunst, Petra Feyer, Rainer Fietkau, Wulf Haase, Wolfgang Harms, Marc D Piroth, Marie-Luise Sautter-Bihl, Felix Sedlmayer, Rainer Souchon, Frederik Wenz, Rolf Sauer
Multimodal treatment approaches have substantially improved the outcome of breast cancer patients in the last decades. Radiotherapy is an integral component of multimodal treatment concepts used in curative and palliative intention in numerous clinical situations from precursor lesions such as ductal carcinoma in situ (DCIS) to advanced breast cancer. This review addresses current controversial topics in radiotherapy with special consideration of DCIS, accelerated partial breast irradiation (APBI) and regional nodal irradiation (RNI) and provides an update on the clinical practice guidelines of the Breast Cancer Expert Panel of the German Society of Radiation Oncology (DEGRO)...
January 23, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28094198/late-side-effects-and-cosmetic-results-of-accelerated-partial-breast-irradiation-with-interstitial-brachytherapy-versus-whole-breast-irradiation-after-breast-conserving-surgery-for-low-risk-invasive-and-in-situ-carcinoma-of-the-female-breast-5-year-results
#12
Csaba Polgár, Oliver J Ott, Guido Hildebrandt, Daniela Kauer-Dorner, Hellen Knauerhase, Tibor Major, Jaroslaw Lyczek, José Luis Guinot, Jürgen Dunst, Cristina Gutierrez Miguelez, Pavel Slampa, Michael Allgäuer, Kristina Lössl, Bülent Polat, György Kovács, Arnt-René Fischedick, Rainer Fietkau, Alexandra Resch, Anna Kulik, Leo Arribas, Peter Niehoff, Ferran Guedea, Annika Schlamann, Richard Pötter, Christine Gall, Wolfgang Uter, Vratislav Strnad
BACKGROUND: We previously confirmed the non-inferiority of accelerated partial breast irradiation (APBI) with interstitial brachytherapy in terms of local control and overall survival compared with whole-breast irradiation for patients with early-stage breast cancer who underwent breast-conserving surgery in a phase 3 randomised trial. Here, we present the 5-year late side-effects and cosmetic results of the trial. METHODS: We did this randomised, controlled, phase 3 trial at 16 centres in seven European countries...
February 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28070767/strut-adjusted-volume-implant-savi-brachytherapy-based-accelerated-partial-breast-irradiation-apbi-in-african-american-women
#13
Amir Isbell, Jacquelyn Dunmore-Griffith, Olubunmi Abayomi
PURPOSE: To examine the clinical outcomes of postmenopausal African American (AA) women treated with strut-adjusted volume implant brachytherapy-based accelerated partial breast irradiation for early-stage node-negative breast cancer. METHODS: From January 2011 through April 2015, a total of 50 AA patients, meeting criteria to receive APBI as defined by the National Surgical Adjuvant Breast and Bowel Project B-39 (NASBP B-39), completed treatment with the SAVI breast brachytherapy device at Howard University Hospital...
January 9, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28063816/trends-in-the-use-of-implantable-accelerated-partial-breast-irradiation-for-ductal-carcinoma-in-situ-implications-of-the-recent-amendments-to-the-american-society-for-radiation-oncology-consensus-guidelines
#14
Waqar Haque, Vivek Verma, Anam Haque, E Brian Butler, Bin S Teh
PURPOSE: In 2009, the American Society for Radiation Oncology (ASTRO) published consensus recommendations that stated ductal carcinoma in situ (DCIS) patients were in a "cautionary" group for accelerated partial breast irradiation (APBI) and should not receive APBI outside of a clinical trial. However, very recently, ASTRO placed low-risk DCIS patients in the "suitable" category. Given this recent change, we aimed to use the Surveillance, Epidemiology, and End Results (SEER) database to evaluate past patterns of implantable APBI (IAPBI) utilization in women with DCIS...
January 4, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28048645/su-f-t-404-dosimetric-advantages-of-flattening-free-beams-to-prone-accelerated-partial-breast-irradiation
#15
P Galavis, D Barbee, G Jozsef
PURPOSE: Prone accelerated partial breast irradiation (APBI) results in dose reduction to the heart and lung. Flattening filter free beams (FFF) reduce out of field dose due to the reduced scatter from the removal of the flattening filter and reduce the buildup region. The aim of this work is to evaluate the dosimetric advantages of FFF beams to prone APBI target coverage and reduction in dose to organs at risk. METHODS: Fifteen clinical prone APBI cases using flattened photon beams were retrospectively re-planned in Eclipse-TPS using FFF beams...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048639/tu-h-209-02-quality-assurance-and-qmp-for-brachytherapy-treatment-delivery-and-treatment-planning-system
#16
M Chilukuri
Learnings Objectives: 1. Although brachytherapy is the oldest form of radiation therapy, the rapid advancement of the methods of dose calculation, treatment planning and treatment delivery pushes us to keep updating our knowledge and experience to new procedures all the time. Our purpose is to present the newest applicators used in Accelerated Partial Breast Irradiation (APBI) and the techniques of using them for a maximum effective treatment. Our objective will be to get the user familiar with the Savi, Contura and ML Mammosite from the detailed description and measurements to cavity eval and choice or size, to acceptance tests and use of each...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048623/tu-fg-201-10-quality-management-of-accelerated-partial-breast-irradiation-apbi-plans
#17
H Ji, V Lorio, G Cernica, J Han, M Nurhussien, N Nasr, R Hong
PURPOSE: Since 2008, over 700 patients received high dose rate (HDR) APBI treatment at Virginia Hospital Center. The complexity involved in the planning process demonstrated a broad variation between patient geometry across all applicators, in relation to anatomical regions of interest. A quality management program instituting various metrics was implemented in March 2013 with the goal of ensuring an optimal plan is achieved for each patient. METHODS: For each plan, an in-house complexity index, geometric conformity index, and plan quality index were defined...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048104/su-f-t-58-dosimetric-evaluation-of-breast-tissue-composition-for-electronic-brachytherapy-bet-source-in-high-dose-rate-accelerated-partial-breast-apbi-irradiation
#18
W Taylor, D Johnson, S Ahmad, Y Chen
PURPOSE: To quantitatively evaluate the dosimetric impact of differing breast tissue compositions for electronic brachytherapy source for high dose rate accelerated partial breast irradiation. METHODS: A series of Monte Carlo Simulation were created using the GEANT4 toolkit (version 10.0). The breast phantom was modeled as a semi-circle with a radius of 5.0 cm. A water balloon with a radius of 1.5 cm was located in the phantom with the Xoft AxxentTM EBT source placed at center as a point source...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047974/tu-h-209-03-planning-and-treatment-delivery-for-apbi-using-savi-contura-and-ml-mammosite
#19
S Pella
Learnings Objectives: 1. Although brachytherapy is the oldest form of radiation therapy, the rapid advancement of the methods of dose calculation, treatment planning and treatment delivery pushes us to keep updating our knowledge and experience to new procedures all the time. Our purpose is to present the newest applicators used in Accelerated Partial Breast Irradiation (APBI) and the techniques of using them for a maximum effective treatment. Our objective will be to get the user familiar with the Savi, Contura and ML Mammosite from the detailed description and measurements to cavity eval and choice or size, to acceptance tests and use of each...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047861/su-f-t-317-skin-exposure-outside-the-treatment-field-during-treatment-of-breast-cancer-with-tri-co-60-mr-igrt-system
#20
J Park, J Kim, S Park, S Kim, K Shin
PURPOSE: To investigate exposure outside the treatment field when treating breast cancer with tri-Co-60 magnetic resonance (MR) image guided radiation therapy (IGRT) system. METHODS: A total of 7 patients who treated with accelerated partial breast irradiation (APBI) technique were selected prospectively for this study (prescription dose = 38.5 Gy in 10 fractions). Every patient treated with two plans, one was an initial plan and the other was an adaptive plan generated after finishing 5 fractions (a total of 14 plans)...
June 2016: Medical Physics
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