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https://www.readbyqxmd.com/read/29755855/association-of-hsp90b1-genetic-polymorphisms-with-efficacy-of-glucocorticoids-and-improvement-of-hrqol-in-systemic-lupus-erythematosus-patients-from-anhui-province
#1
Xiu-Xiu Sun, Su-Su Li, Man Zhang, Qiao-Mei Xie, Jian-Hua Xu, Sheng-Xiu Liu, Yuan-Yuan Gu, Fa-Ming Pan, Jin-Hui Tao, Sheng-Qian Xu, Shuang Liu, Jing Cai, De-Guang Wang, Long Qian, Chun-Huai Wang, Li Lian, Hui Xiao, Pei-Ling Chen, Chun-Mei Liang, You-Bing Fang, Qiang Zhou, Hai-Liang Huang, Hong Su, Hai-Feng Pan, Dong-Qing Ye, Yan-Feng Zou
Objective: The aim of this study was to investigate the associations between HSP90B1 gene polymorphisms and the efficacy of glucocorticoids (GCs) and the improvement of health-related quality of life (HRQoL) in Anhui patients with systemic lupus erythematosus (SLE). Method: A total of 305 patients with SLE were recruited to the study. These patients were treated with GCs for 12 weeks and classified into two groups (sensitivity and insensitivity) according to the response to GCs measured by the scores on SLE disease activity index (SLEDAI)...
2018: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29689388/neutrophil-and-platelet-to-lymphocyte-ratios-in-associating-with-blood-glucose-admission-predict-the-functional-outcomes-of-patients-with-primary-brainstem-hemorrhage
#2
F Zhang, H Li, C Tao, J Zheng, X Hu, S Lin, J Qian, C You, M Yang
BACKGROUND: Due to lack of markers for predicting the prognosis as well as the under mechanism is unrevealed, patients with primary brainstem hemorrhage (PBH) were currently treated by multi-strategies but most of them have poor outcomes by comparing with supratentorial intracranial hemorrhage patients. Recently, it has been reported that the ratio of neutrophil to lymphocyte (NLR) represents a novel composite inflammatory marker to predict the prognosis of patients with intracranial hemorrhage, where majority are supratentorial hemorrhage...
April 21, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29429444/safety-and-affordability-of-an-elective-saturday-list-at-pietersburg-hospital-limpopo-south-africa
#3
M M Z U Bhuiyan, R Mavhungu
BACKGROUND: The backlog of patients waiting for operations continues to be a problem in many public hospitals in South Africa (SA), with elective surgery procedures being postponed for up to 2 years. OBJECTIVE: To determine the rate of death in hospital or out of hospital within 30 days of an elective procedure performed on a Saturday, and to determine the cost incurred by paying staff members who perform these operations. METHOD: A prospective, observational descriptive cohort study of all patients undergoing inpatient general surgery operations during weekdays and weekends between 1 September 2015 and 31 August 2016 (1 year) at Pietersburg Hospital (PBH), Limpopo, SA...
February 1, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29355439/design-and-clinical-evaluation-of-a-novel-low-glucose-prediction-algorithm-with-mini-dose-stable-glucagon-delivery-in-post-bariatric-hypoglycemia
#4
Alejandro J Laguna Sanz, Christopher M Mulla, Kristen M Fowler, Emilie Cloutier, Allison B Goldfine, Brett Newswanger, Martin Cummins, Sunil Deshpande, Steven J Prestrelski, Poul Strange, Howard Zisser, Francis J Doyle, Eyal Dassau, Mary-Elizabeth Patti
BACKGROUND: Postbariatric hypoglycemia (PBH) is a complication of bariatric surgery with limited therapeutic options. We developed an event-based system to predict and detect hypoglycemia based on continuous glucose monitor (CGM) data and recommend delivery of minidose liquid glucagon. METHODS: We performed an iterative development clinical study employing a novel glucagon delivery system: a Dexcom CGM connected to a Windows tablet running a hypoglycemia prediction algorithm and an Omnipod pump filled with an investigational stable liquid glucagon formulation...
February 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29341709/probing-primordial-black-hole-dark-matter-with-gravitational-waves
#5
Ely D Kovetz
Primordial black holes (PBHs) have long been suggested as a candidate for making up some or all of the dark matter in the Universe. Most of the theoretically possible mass range for PBH dark matter has been ruled out with various null observations of expected signatures of their interaction with standard astrophysical objects. However, current constraints are significantly less robust in the 20  M_{⊙}≲M_{PBH}≲100  M_{⊙} mass window, which has received much attention recently, following the detection of merging black holes with estimated masses of ∼30  M_{⊙} by LIGO and the suggestion that these could be black holes formed in the early Universe...
September 29, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29310320/in-situ-synthesized-and-embedded-silver-nanoclusters-into-poly-vinyl-alcohol-borax-hydrogel-as-a-novel-dual-mode-on-and-off-fluorescence-sensor-for-fe-iii-and-thiosulfate
#6
Nahid Pourreza, Matineh Ghomi
Herein, a novel method has been developed for in situ synthesis and embedding of silver nanoclusters (AgNCs) into polyvinyl alcohol and borax hydrogel (PBH) without adding any reducing agent. A three-dimensional network of polyvinyl alcohol and borax is formed, and at the same time the silver ions penetrate into the hydrogel, reduced to silver and trapped into the hydrogel bed. The characteristics of this hydrogel nanocomposite were investigated by energy dispersive X-ray spectroscopy and transmission electron microscopy (TEM)...
March 1, 2018: Talanta
https://www.readbyqxmd.com/read/29177012/crispr-like-sequences-in-helicobacter-pylori-and-application-in-genotyping
#7
Khotchawan Bangpanwimon, Jaksin Sottisuporn, Pimonsri Mittraparp-Arthorn, Warattaya Ueaphatthanaphanich, Attapon Rattanasupar, Christine Pourcel, Varaporn Vuddhakul
Background: Many bacteria and archaea possess a defense system called clustered regularly interspaced short palindromic repeats (CRISPR) associated proteins (CRISPR-Cas system) against invaders such as phages or plasmids. This system has not been demonstrated in Helicobacter pylori . The numbers of spacer in CRISPR array differ among bacterial strains and can be used as a genetic marker for bacterial typing. Results: A total of 36 H. pylori isolates were collected from patients in three hospitals located in the central (PBH) and southern (SKH) regions of Thailand...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/29166709/-effects-of-dexmedetomidine-on-myocardium-of-rats-with-severe-burn-at-early-stage
#8
D Wang, P L Yang, X Zhang, Y Liu
Objective: To investigate the effects of dexmedetomidine on myocardium of rats at early stage after severe burn. Methods: Twenty specific pathogen free male SD rats were immersed in 90 ℃ hot water for 20 s, causing 30% total body surface area (TBSA) full-thickness scald (hereafter referred to as burn) on the back. And then they were divided into burn resuscitation group (BR) and burn resuscitation+ dexmedetomidine group (BRD) according to the random number table, with 10 rats in each group. Sodium lactate Ringer's solution (2 mL·kg(-1)·%TBSA(-1)) were intraperitoneally injected into rats of both groups after burn...
November 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29115156/development-and-evaluation-of-novel-recombinant-adenovirus-based-vaccine-candidates-for-infectious-bronchitis-virus-and-mycoplasma-gallisepticum-in-chickens
#9
Dongchao Zhang, Yuqing Long, Meng Li, Jianfang Gong, Xiaohui Li, Jing Lin, Jiali Meng, Keke Gao, Ruili Zhao, Tianming Jin
Avian infectious bronchitis caused by the infectious bronchitis virus (IBV), and mycoplasmosis caused by Mycoplasma gallisepticum (MG) are two major respiratory diseases in chickens that have resulted in severe economic losses in the poultry industry. We constructed a recombinant adenovirus that simultaneously expresses the S1 spike glycoprotein of IBV and the TM-1 protein of MG (pBH-S1-TM-1-EGFP). For comparison, we constructed two recombinant adenoviruses (pBH-S1-EGFP and pBH-TM-1-EGFP) that express either the S1 spike glycoprotein or the TM-1 protein alone...
April 2018: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28984075/association-of-glucocorticoid-receptor-gene-polymorphisms-with-systemic-lupus-erythematosus-in-a-chinese-population
#10
Yang-Fan Chen, Jian-Hua Xu, Yan-Feng Zou, Li Lian, Fen Wang, Shan-Yu Chen, Jing Cai, Mu Li
OBJECTIVES: To identify the association of glucocorticoid receptor (GR) gene polymorphism with systemic lupus erythematosus (SLE). METHODS: A case-control study was carried out, in which 400 Chinese patients with SLE and 400 normal people were enrolled. DNA was extracted using a genomic DNA extraction kit, and tagged single nucleotide polymorphisms (SNPs) were identified by Haploview (4.0) Project from the Chinese HapMap Project. Eighteen tagged SNPs of the GR gene were genotyped by the Multiplex SNaPshot technique...
December 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28949605/primordial-black-holes-and-r-process-nucleosynthesis
#11
George M Fuller, Alexander Kusenko, Volodymyr Takhistov
We show that some or all of the inventory of r-process nucleosynthesis can be produced in interactions of primordial black holes (PBHs) with neutron stars (NSs) if PBHs with masses 10^{-14}  M_{⊙}<M_{PBH}<10^{-8}  M_{⊙} make up a few percent or more of dark matter. A PBH captured by a NS sinks to the center of the NS and consumes it from the inside. When this occurs in a rotating millisecond-period NS, the resulting spin-up ejects ∼0.1  M_{⊙}-0.5  M_{⊙} of relatively cold neutron-rich material...
August 11, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28797801/dimeric-and-trimeric-homo-and-heteroleptic-hydroxamic-acid-macrocycles-formed-using-mixed-ligand-fe-iii-based-metal-templated-synthesis
#12
Athavan Sresutharsan, William Tieu, Tomas Richardson-Sanchez, Cho Zin Soe, Rachel Codd
Macrocyclic hydroxamic acids coordinate Fe(III) with high affinity as part of siderophore-mediated bacterial iron acquisition. Trimeric hydroxamic acid macrocycles, such as desferrioxamine E (DFOE), are prevalent in nature, with fewer dimeric macrocycles identified, including putrebactin (pbH2 ), avaroferrin (avH2 ), bisucaberin (bsH2 ) and alcaligin (alH2 ). This work used metal-templated synthesis (MTS) to pre-assemble complexes between one equivalent of Fe(III) and two equivalents of 4-((4-aminobutyl)(hydroxy)amino)-4-oxobutanoic acid (BBH) or 4-((5-aminopentyl)(hydroxy)amino)-4-oxobutanoic acid (PBH)...
December 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28777598/primordial-black-holes-from-supersymmetry-in-the-early-universe
#13
Eric Cotner, Alexander Kusenko
Supersymmetric extensions of the standard model generically predict that in the early Universe a scalar condensate can form and fragment into Q balls before decaying. If the Q balls dominate the energy density for some period of time, the relatively large fluctuations in their number density can lead to formation of primordial black holes (PBH). Other scalar fields, unrelated to supersymmetry, can play a similar role. For a general charged scalar field, this robust mechanism can generate black holes over the entire mass range allowed by observational constraints, with a sufficient abundance to account for all dark matter in some parameter ranges...
July 21, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28776922/efficacy-and-pharmacokinetics-of-subcutaneous-exendin-9-39-in-patients-with-post-bariatric-hypoglycaemia
#14
Colleen M Craig, Li-Fen Liu, Thi Nguyen, Candice Price, Justus Bingham, Tracey L McLaughlin
AIM: To evaluate the efficacy, pharmacokinetic (PK) profile and tolerability of subcutaneous (s.c.). exendin 9-39 (Ex-9) injection in patients with post-bariatric hypoglycaemia (PBH). METHODS: Nine women who had recurrent symptomatic hypoglycaemia after undergoing Roux-en-Y gastric bypass were enrolled in this 2-part, single-blind, single-ascending-dose study. In Part 1, a single participant underwent equimolar low-dose intravenous (i.v.) vs s.c. Ex-9 administration; in Part 2, 8 participants were administered single ascending doses of s...
February 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28732671/psoas-hitch-ureteral-reimplantation-after-surgery-for-locally-advanced-and-locally-recurrent-colorectal-cancer-complications-and-oncological-outcome
#15
F van den Heijkant, T A Vermeer, E J E J Vrijhof, G A P Nieuwenhuijzen, E L Koldewijn, H J T Rutten
INTRODUCTION: The most important prognostic factor for oncological outcome of rectal cancer is radical surgical resection. In patients with locally advanced T4 rectal cancer (LARC) or locally recurrent rectal cancer (LRRC) (partial) resection of the urinary tract is frequently required to achieve radical resection. The psoas bladder hitch (PBH) technique is the first choice for reconstruction of the ureter after partial resection and this bladder-preserving technique should not influence the oncological outcome...
October 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28721283/stereological-comparison-of-intraprostatic-injection-of-alcohol-and-bleomycin-with-finasteride-gavages-in-rats
#16
Ali Eslahi, Ali Noorafshan, Ali-Reza Safarpour, Masood Sepehrimanesh, Ali Ariafara, Elham Nadimi
INTRODUCTION: Resection of the prostate is one of the standard surgical treatments for symptomatic Benign Prostatic Hyperplasia (BPH). To evaluate minimally invasive treatments, intraprostatic injections of ethanol and bleomycin were compared with oral finasteride administration in rats with BPH. MATERIAL AND METHODS: The rats were divided into six groups. The control rats received no BPH/no treatment. BPH was induced using injections of testosterone (2 mg/day/rat for 4 weeks) in groups II-VI...
June 30, 2017: Central European Journal of Urology
https://www.readbyqxmd.com/read/28650492/exploiting-the-biosynthetic-machinery-of-streptomyces-pilosus-to-engineer-a-water-soluble-zirconium-iv-chelator
#17
Tomas Richardson-Sanchez, William Tieu, Michael P Gotsbacher, Thomas J Telfer, Rachel Codd
The water solubility of a natural product-inspired octadentate hydroxamic acid chelator designed to coordinate Zr(iv)-89 has been improved by using a combined microbiological-chemical approach to engineer four ether oxygen atoms into the main-chain region of a methylene-containing analogue. First, an analogue of the trimeric hydroxamic acid desferrioxamine B (DFOB) that contained three main-chain ether oxygen atoms (DFOB-O3 ) was generated from cultures of the native DFOB-producer Streptomyces pilosus supplemented with oxybis(ethanamine) (OBEA), which competed against the native 1,5-diaminopentane (DP) substrate during DFOB assembly...
July 21, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28564674/association-of-a-policy-mandating-physician-patient-communication-with-racial-ethnic-disparities-in-postmastectomy-breast-reconstruction
#18
Elham Mahmoudi, Yiwen Lu, Allan K Metz, Adeyiza O Momoh, Kevin C Chung
Importance: With the stabilization of breast cancer incidence and substantial improvement in survival, more attention has focused on postmastectomy breast reconstruction (PBR). Despite its demonstrated benefits, wide disparities in the use of PBR remain. Physician-patient communication has an important role in disparities in health care, especially for elective surgical procedures. Recognizing this, the State of New York enacted Public Health Law (NY PBH Law) 2803-o in 2011 mandating that physicians communicate about reconstructive surgery with patients undergoing mastectomy...
August 1, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28392017/medical-nutrition-therapy-for-post-bariatric-hypoglycemia-practical-insights
#19
Emmy Suhl, Sue-Ellen Anderson-Haynes, Christopher Mulla, Mary-Elizabeth Patti
Hypoglycemia is increasingly recognized as a complication of bariatric surgery. Although medications are often required, medical nutrition therapy remains the key cornerstone for successful prevention of hypoglycemia in patients with post-bariatric hypoglycemia (PBH). We provide suggested approaches to the dietary management of PBH, incorporating data from both the medical literature and extensive clinical experience in an academic referral center for PBH. The overall goal of medical nutrition therapy for PBH is to reduce postprandial surges in glucose, which often trigger surges in insulin secretion and promote subsequent hypoglycemia...
May 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28370072/expression-profiling-of-sudanese-visceral-leishmaniasis-patients-pre-and-post-treatment-with-sodium-stibogluconate
#20
M A M Salih, M Fakiola, P A Lyons, B M Younis, A M Musa, A M Elhassan, D Anderson, G Syn, M E Ibrahim, J M Blackwell, H S Mohamed
Visceral leishmaniasis (VL) in Sudan caused by Leishmania donovani is fatal in susceptible individuals if untreated. Treatment with sodium stibogluconate (SSG) leads to post-kala-azar dermal leishmaniasis (PKDL) in 58% of patients. Here, Affymetrix microarrays were used to identify genes differentially expressed in lymph nodes (N=9 paired samples) pre- and post-treatment with SSG. Using the Bioconductor package limma, 438 genes from 28 869 post-quality-control probe sets were differentially expressed (Pnominal ≤...
June 2017: Parasite Immunology
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