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Jan Langmaier, Martin Pižl, Zdeněk Samec, Stanislav Záliš
Ion transfer voltammetry is used to estimate the acid dissociation constants Ka1 and Ka2 of the mono- and diprotonated forms of the biguanide drugs metformin (MF), phenformin (PF), and 1-phenylbiguanide (PB) in an aqueous solution. Measurements gave the pKa1 values for MFH(+), PFH(+), and PBH(+) characterizing the basicity of MF, PF, and PB, which are significantly higher than those reported in the literature. As a result, the monoprotonated forms of these biguanides should prevail in a considerably broader range of pH 1-15 (MFH(+), PFH(+)) and 2-13 (PBH(+))...
September 22, 2016: Journal of Physical Chemistry. A
Mauro Dobran, Davide Nasi, Denise Brunozzi, Lucia di Somma, Maurizio Gladi, Maurizio Iacoangeli, Massimo Scerrati
BACKGROUND: The surgical management of thoracolumbar burst fractures frequently involves posterior pedicle screw fixation. However, the application of short- or long-segment instrumentation is still controversial. The aim of this study was to compare the outcome of the short-segment fixation with inclusion of the fracture level (SSFIFL) versus the traditional long-segment fixation (LSF) for the treatment of unstable thoracolumbar junction fractures. METHODS: From December 2009 to February 2014, 60 patients with unstable thoracolumbar junction fractures (T11-L2) were divided into two groups according to the number of instrumented levels...
October 2016: Acta Neurochirurgica
Misao Sasaki, Teruaki Suyama, Takahiro Tanaka, Shuichiro Yokoyama
We point out that the gravitational-wave event GW150914 observed by the LIGO detectors can be explained by the coalescence of primordial black holes (PBHs). It is found that the expected PBH merger rate would exceed the rate estimated by the LIGO Scientific Collaboration and the Virgo Collaboration if PBHs were the dominant component of dark matter, while it can be made compatible if PBHs constitute a fraction of dark matter. Intriguingly, the abundance of PBHs required to explain the suggested lower bound on the event rate, >2  events  Gpc^{-3} yr^{-1}, roughly coincides with the existing upper limit set by the nondetection of the cosmic microwave background spectral distortion...
August 5, 2016: Physical Review Letters
Xiang Jiang, Fei Kuang, Fansheng Kong, Chunyan Yan
Benincasa hispida is a popular vegetable in China. Our previous experiments suggested that polysaccharides isolated from B. hispida fruits (PBH) have antiglycation effect and DPPH free radical scavenging activity. Ultrasonic treatments can be used to extract polysaccharides from Benincasa hispida (PBH). The aim of this study was to investigate the correlation between the ultrasonic treatment conditions and the antiglycation activity of PBH. A mathematical model was generated with an artificial neural network (ANN) toolbox from MATLAB to analyze the effects of ultrasonic treatment conditions on antiglycation activity...
October 20, 2016: Carbohydrate Polymers
Shirin Shahbazi, Maryam Khorasani, Reza Mahdian
OBJECTIVES: The ectopic expression of coagulation Factor VII has been shown in various cancers. Recently, F7 gene has been identified as a direct target of the androgen receptor in breast cancer. In this study, we examined the mRNA expression of F7 and AR in clinical sample series of prostate cancer and BPH. MATERIAL AND METHODS: All the prostate cancer patients were new cases with no medical history of surgery or chemotherapy. The tissue samples were assigned as either prostate cancer tumor (n= 45) harboring at least 80% tumor cell content, or BPH (n= 36)...
July 8, 2016: Cancer Biomarkers: Section A of Disease Markers
Mehdi Khemiss, Mohamed Ben Khelifa, Mohamed Ben Rejeb, Helmi Ben Saad
OBJECTIVE: To compare the periodontal bone height (PBH) of exclusive narghile smokers (ENS) with that of exclusive cigarette smokers (ECS). METHODS: Tunisian males aged 20-35 years who have been ENS for more than five narghile-years or ECS for more than five pack-years were recruited to participate in this comparative cross-sectional study. Information about oral health habits and tobacco consumption were gathered using a predetermined questionnaire. Plaque levels were recorded in four sites using the plaque index of Loe and Silness...
2016: Libyan Journal of Medicine
Cody A Melton, M Chandler Bennett, Lubos Mitas
We investigate the inclusion of variable spins in electronic structure quantum Monte Carlo, with a focus on diffusion Monte Carlo with Hamiltonians that include spin-orbit interactions. Following our previous introduction of fixed-phase spin-orbit diffusion Monte Carlo, we thoroughly discuss the details of the method and elaborate upon its technicalities. We present a proof for an upper-bound property for complex nonlocal operators, which allows for the implementation of T-moves to ensure the variational property...
June 28, 2016: Journal of Chemical Physics
Simeon Bird, Ilias Cholis, Julian B Muñoz, Yacine Ali-Haïmoud, Marc Kamionkowski, Ely D Kovetz, Alvise Raccanelli, Adam G Riess
We consider the possibility that the black-hole (BH) binary detected by LIGO may be a signature of dark matter. Interestingly enough, there remains a window for masses 20M_{⊙}≲M_{bh}≲100M_{⊙} where primordial black holes (PBHs) may constitute the dark matter. If two BHs in a galactic halo pass sufficiently close, they radiate enough energy in gravitational waves to become gravitationally bound. The bound BHs will rapidly spiral inward due to the emission of gravitational radiation and ultimately will merge...
May 20, 2016: Physical Review Letters
Davide Nasi, Mauro Dobran, Maurizio Iacoangeli, Lucia Di Somma, Maurizio Gladi, Massimo Scerrati
BACKGROUND: Paradoxical brain herniation (PBH) is a rare and potentially life-threatening complication of decompressive craniectomy (DC) and results from the combined effects of brain gravity, atmospheric pressure and intracranial hypotension causing herniation in the direction opposite to the site of the DC with subsequent brainstem compression. To date, the cases of PBH reported in literature are spontaneous or provoked by a lumbar puncture, a cerebrospinal fluid (CSF) shunt, or ventriculostomy...
July 2016: World Neurosurgery
Damianos G Paschalidis, William T A Harrison
The gel-mediated syntheses and crystal structures of [N'-(pyridin-2-ylmethylidene-κN)benzohydrazide-κ(2) N',O]tris(thiocyanato-κN)praseodymium(III) mono-hydrate, [Pr(NCS)3(C13H11N3O)2]·H2O, (I), and aqua(nitrato-κ(2) O,O')[N'-(pyri-din-2-ylmethylidene-κN)benzohydrazide-κ(2) N',O](thiocyanato-κN)neo-dym-ium(III) nitrate 2.33-hydrate, [Nd(NCS)(NO3)(C13H11N3O)2(H2O)]NO3·2.33H2O, (II), are reported. The Pr(3+) ion in (I) is coordinated by two N,N,O-tridentate N'-(pyridin-2-ylmethylidene)benzohydrazide (pbh) ligands and three N-bonded thio-cyanate ions to generate an irregular PrN7O2 coordination polyhedron...
February 1, 2016: Acta Crystallographica. Section E, Crystallographic Communications
Z Saker, O Tsintsadze, I Jiqia, L Managadze, A Chkhotua
MDM2, Bcl-2 and Bax are well recognized markers of apoptosis. The goal of the current study was evaluation of the activity of these markers in different cells of BPH, PCa and hormonally treated prostate cancer (CRPCa) tissues. Activity of the markers has been evaluated in: 39 BPH, 28 prostate cancer (PCa) and 10 castration resistant PCa (CRPCa) tissues. Possible association of intensity of the expression with the disease clinical parameters has been assessed. Activity of MDM2 was higher in PCa and CRPCa as compared with BPH...
December 2015: Georgian Medical News
Leonel R Jimenez, Wiley A Hall, Matthew S Rodriquez, William J Cooper, Jeanette Muhareb, Tom Jones, Spencer S Walse
A novel analytical approach involving solvent extraction with methyl tert-butyl ether (MTBE) followed by GC was developed to quantify residues that result from the postharvest fumigation of almonds and walnuts with propylene oxide (PPO). Verification and quantification of PPO, propylene chlorohydrin (PCH) [1-chloropropan-2-ol (PCH-1) and 2-chloropropan-1-ol (PCH-2)], and propylene bromohydrin (PBH) [1-bromopropan-2-ol (PBH-1) and 2-bromopropan-1-ol (PBH-2)] was accomplished with a combination of electron impact ionization MS (EIMS), negative ion chemical ionization MS (NCIMS), and electron capture detection (ECD)...
September 2015: Journal of AOAC International
Vikas Moolchandani, Larry L Augsburger, Abhay Gupta, Mansoor A Khan, John Langridge, Stephen W Hoag
This study is the second in a series that examines the characterizing and selection of suitable grades of lactose for capsule formulation development. Based upon the previous study, four grades were selected for further study. The effects of drug load and operational variables on formulations derived from these four lactose types were evaluated for physicochemical and mechanical attributes of plugs and their capsules on an instrumented dosing-disc capsule filling machine (H&H KFM/3) using acetaminophen as a model, highly soluble and poorly compressible drug...
2016: Drug Development and Industrial Pharmacy
Tatiana Sadak, Anna Korpak, Soo Borson
UNLABELLED: Improving the quality of health care for individuals living with dementia is a central goal of the National Alzheimer's Plan, and requires the participation of informed family caregivers as active members of the patient's health care team. "Caregiver activation" is an emerging concept for which dementia-specific measures are lacking. We developed and validated a new self-report index of caregiver activation, Partnering for Better Health - Living with Chronic Illness: Dementia ( PBH-LCI: D)...
July 2015: Geriatric Nursing
Ghassan Alya, Adnan Ekhtiar, George Saour
PURPOSE: The radioprotectors currently available are generally poorly tolerated in human beings; thus, their use has been restricted due to their side effects and their limited clinical tolerance. In a search for fewerand/or without side effects agents, the radioprotective effects of partial body hyperthermia (PBH) were tested on Wistar rats of both sexes at different ages. MATERIALS AND METHODS: PBH (43 °C, 1 h) was carried out by immersion of each animal's lower parts and legs in a thermostatically controlled water bath 20 h prior to irradiation with a lethal single exposure dose of 9 Gy of gamma irradiation...
2015: International Journal of Hyperthermia
Tulip Lifa, William Tieu, Rosalie K Hocking, Rachel Codd
A metal-templated synthesis (MTS) approach was used to preorganize the forward endo-hydroxamic acid monomer 4-[(5-aminopentyl)(hydroxy)amino]-4-oxobutanoic acid (for-PBH) about iron(III) in a 1:3 metal/ligand ratio to furnish the iron(III) siderophore for-[Fe(DFOE)] (ferrioxamine E) following peptide coupling. Substitution of for-PBH with the reverse (retro) hydroxamic acid analogue 3-(6-amino-N-hydroxyhexanamido)propanoic acid (ret-PBH) furnished ret-[Fe(DFOE)] (ret-ferrioxamine E). As isomers, for-[Fe(DFOE)] and ret-[Fe(DFOE)] gave identical mass spectrometry signals ([M + H(+)](+), m/zcalc 654...
April 6, 2015: Inorganic Chemistry
Weigang Hu, Guichao Li, Jinsong Ye, Jiazhou Wang, Jiayuan Peng, Min Gong, Xiaoli Yu, Matthew T Studentski, Ying Xiao, Zhen Zhang
BACKGROUND AND PURPOSE: To report preliminary results of passive breath gating (PBG) equipment for cone-beam CT image-guided gated RapidArc gastric cancer treatments. MATERIAL AND METHODS: Home-developed PBG equipment integrated with the real-time position management system (RPM) for passive patient breath hold was used in CT simulation, online partial breath hold (PBH) CBCT acquisition, and breath-hold gating (BHG) RapidArc delivery. The treatment was discontinuously delivered with beam on during BH and beam off for free breathing (FB)...
January 2015: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Feng Guo, Xun Liang, Jingning Huan
OBJECTIVE: To explore the relationship between continuous thrombocytopenia and sepsis in patients with severe burns. METHODS: Clinical data of 148 severely burned patients admitted to our,two burn centers from January 2007 to December 2011 and conforming to the study criteria were retrospectively analyzed. All patients were divided into sepsis group (n =44) and non-sepsis group (n = 104) according to the presence or absence of sepsis within post burn day (PBD) 30...
August 2014: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
Kieran Samuk, Davis Iritani, Dolph Schluter
Uncovering factors that shape variation in brain morphology remains a major challenge in evolutionary biology. Recently, it has been shown that brain size is positively associated with level of parental care behavior in various taxa. One explanation for this pattern is that the cognitive demands of performing complex parental care may require increased brain size. This idea is known as the parental brain hypothesis (PBH). We set out to test the predictions of this hypothesis in wild populations of threespine stickleback (Gasterosteus aculeatus)...
August 2014: Ecology and Evolution
Feng Guo, Xun Liang, Jingning Huan
OBJECTIVE: To explore the relationship between continuous thrombocytopenia and sepsis in patients with severe burns. METHODS: Clinical data of 148 severely burned patients admitted to our,two burn centers from January 2007 to December 2011 and conforming to the study criteria were retrospectively analyzed. All patients were divided into sepsis group (n =44) and non-sepsis group (n = 104) according to the presence or absence of sepsis within post burn day (PBD) 30...
August 2014: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
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