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https://www.readbyqxmd.com/read/29780704/a-promising-result-of-locoregional-tumor-control-with-biologically-adaptive-radiotherapy-in-patients-with-locally-advanced-non-small-cell-lung-cancer
#1
EDITORIAL
Yukinori Matsuo
No abstract text is available yet for this article.
April 2018: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29780046/-study-of-dose-recalculation-method-on-overriding-lung-density-using-cbct-image-in-the-thorax
#2
Hiroshi Watanabe, Shuichi Ozawa, Atsuyuki Ohashi, Koji Ikenaga, Kentaro Miki, Akito Saito, Teiji Nishio, Yuji Murakami, Yasushi Nagata
It is a useful method for the adaptive radiotherapy (ART) to calculate absorbed dose accurately on the image set taken by on-board cone beam computed tomography (CBCT) attached to linac for image-guided radiation therapy (IGRT). For this purpose, a simple and accurate calculation method is necessary. Several papers report that it is possible to calculate easily and accurately by using several methods of researches in the neck and prostate, but the lung density varies greatly depending on patient thorax condition...
2018: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/29778738/risk-adapted-therapy-for-young-children-with-medulloblastoma-sjyc07-therapeutic-and-molecular-outcomes-from-a-multicentre-phase-2-trial
#3
Giles W Robinson, Vasilisa A Rudneva, Ivo Buchhalter, Catherine A Billups, Sebastian M Waszak, Kyle S Smith, Daniel C Bowers, Anne Bendel, Paul G Fisher, Sonia Partap, John R Crawford, Tim Hassall, Daniel J Indelicato, Frederick Boop, Paul Klimo, Noah D Sabin, Zoltan Patay, Thomas E Merchant, Clinton F Stewart, Brent A Orr, Jan O Korbel, David T W Jones, Tanvi Sharma, Peter Lichter, Marcel Kool, Andrey Korshunov, Stefan M Pfister, Richard J Gilbertson, Robert P Sanders, Arzu Onar-Thomas, David W Ellison, Amar Gajjar, Paul A Northcott
BACKGROUND: Young children with medulloblastoma have a poor overall survival compared with older children, due to use of radiation-sparing therapy in young children. Radiotherapy is omitted or reduced in these young patients to spare them from debilitating long-term side-effects. We aimed to estimate event-free survival and define the molecular characteristics associated with progression-free survival in young patients with medulloblastoma using a risk-stratified treatment strategy designed to defer, reduce, or delay radiation exposure...
May 16, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29778279/outcomes-after-surgical-resection-of-lower-eyelid-tumors-and-reconstruction-using-a-nasal-chondromucosal-graft-and-an-upper-eyelid-myocutaneous-flap
#4
S Lemaître, C Lévy-Gabriel, L Desjardins, M González-Candial, S Gardrat, R Dendale, N Cassoux, B Couturaud
INTRODUCTION: Surgical excision of large malignant lower eyelid tumors may cause important full-thickness eyelid defects. The reconstruction of such defects must restore the physiologic function of the eyelid and also re-establish an acceptable aesthetic result. MATERIALS AND METHODS: We report the outcomes of full-thickness excision of tumors extending over half of the horizontal lid length, followed by reconstruction using a nasal chondromucosal graft (coming from the ipsilateral ala of the nose) and an upper eyelid myocutaneous flap...
May 16, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29777595/a-ring-based-compensator-imrt-system-optimized-for-low-and-middle-income-countries-design-and-treatment-planning-study
#5
Jonathon Van Schelt, Daniel Smith, Nicholas Fong, Dolla Toomeh, Patricia A Sponseller, Derek W Brown, Meghan W Macomber, Nina A Mayr, Shilpen Patel, Adam Shulman, G V Subrahmanyam, K Govindarajan, Eric C Ford
PURPOSE: We propose a novel compensator-based IMRT system designed to provide a simple, reliable, and cost-effective adjunct technology, with the goal of expanding global access to advanced radiotherapy techniques. The system would employ easily-reusable tungsten bead compensators that operate independent of a gantry (e.g. mounted in a ring around the patient). Thereby the system can be retrofitted to existing linac and cobalt teletherapy units. This study explores the quality of treatment plans from the proposed system and the dependence on associated design parameters...
May 19, 2018: Medical Physics
https://www.readbyqxmd.com/read/29772061/an-image-guided-radiotherapy-decision-support-framework-incorporating-a-bayesian-network-and-visualization-tool
#6
Catriona Hargrave, Timothy Deegan, Tomasz Bednarz, Michael Poulsen, Fiona Harden, Kerrie Mengersen
PURPOSE: To describe a Bayesian network (BN) and complementary visualization tool, that aim to support decision-making during online cone-beam computed tomography (CBCT)-based image guide radiotherapy (IGRT) for prostate cancer patients. METHODS: The BN was created to represent relationships between observed prostate, proximal seminal vesicle (PSV), bladder and rectum volume variations, an image feature alignment score (FASTV _ OAR ), delivered dose and treatment plan compliance (TPC)...
May 17, 2018: Medical Physics
https://www.readbyqxmd.com/read/29772057/a-4d-global-respiratory-motion-model-of-the-thorax-based-on-ct-images-a-proof-of-concept
#7
H Fayad, M Gilles, T Pan, D Visvikis
PURPOSE: Respiratory motion reduces the sensitivity and specificity of medical images especially in the thoracic and abdominal areas. It may affect applications such as cancer diagnostic imaging and/or radiation therapy (RT). Solutions to this issue include modelling of the respiratory motion in order to optimize both diagnostic and therapeutic protocols. Personalised motion modeling required patient specific four dimensional (4D) imaging which in the case of 4D computed tomography (4D CT) acquisition is associated with an increased dose...
May 17, 2018: Medical Physics
https://www.readbyqxmd.com/read/29771683/an-individualized-strategy-to-estimate-the-effect-of-deformable-registration-uncertainty-on-accumulated-dose-in-the-upper-abdomen
#8
Yibing Wang, Steven F Petit, Eliana Vasquez Osorio, Vikas Gupta, Alejandra Méndez Romero, Ben J M Heijmen
In the abdomen, it is challenging to assess the accuracy of deformable image registration (DIR) for individual patients, due to the lack of clear anatomical landmarks, which can hamper clinical applications that require high accuracy DIR, such as adaptive radiotherapy. In this study, we propose and evaluate a methodology for estimating the impact of uncertainties in DIR on calculated accumulated dose in the upper abdomen, in order to aid decision making in adaptive treatment approaches. 
 Sixteen liver metastasis patients treated with SBRT were evaluated...
May 17, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29771238/on-the-direct-acquisition-of-beam-s-eye-view-images-in-mri-for-integration-with-external-beam-radiotherapy
#9
Keith Wachowicz, Brad Murray, B Gino Fallone
The recent interest in the integration of external beam radiotherapy with a magnetic resonance (MR) imaging unit offers the potential for real-time adaptive tumour tracking during radiation treatment. The tracking of large tumours which follow a rapid trajectory may best be served by the generation of a projection image from the perspective of the beam source, or "beam's eye view" (BEV). This type of image projection represents the path of the radiation beam, thus enabling rapid compensations for target translations, rotations and deformations, as well time-dependent critical structure avoidance...
May 17, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29765792/stereotactic-mri-guided-adaptive-radiation-therapy-smart-for-locally-advanced-pancreatic-cancer-a-promising-approach
#10
Elaine Luterstein, Minsong Cao, James Lamb, Ann C Raldow, Daniel A Low, Michael L Steinberg, Percy Lee
Locally advanced pancreatic cancer (LAPC) is characterized by poor prognosis and low response durability with standard-of-care chemotherapy or chemoradiotherapy treatment. Stereotactic body radiation therapy (SBRT), which has a shorter treatment course than conventionally fractionated radiotherapy and allows for better integration with systemic therapy, may confer a survival benefit but is limited by gastrointestinal toxicity. Stereotactic MRI-guided adaptive radiation therapy (SMART) has recently gained attention for its potential to increase treatment precision and thus minimize this toxicity through continuous real-time soft-tissue imaging during radiotherapy...
March 14, 2018: Curēus
https://www.readbyqxmd.com/read/29750135/pitfalls-of-ovarian-ablative-magnetic-resonance-guided-radiation-therapy-for-refractory-endometriosis
#11
Shyama Tetar, Anna Bruynzeel, Omar Bohoudi, Theodoor Nieboer, Frank Lagerwaard
In this case presentation, we describe the challenges of performing magnetic resonance-guided radiation therapy (MRgRT) with plan adaptation in a patient with advanced endometriosis, in whom several prior therapeutic attempts were unsuccessful and extensive pelvic irradiation was regarded as being too toxic. Treatment was delivered in two sessions, first for the seemingly only active right ovary, and at a later stage for the left ovary. Some logistical problems were encountered during the preparation of the first treatment, which were subsequently optimized for the second treatment by using transvaginal ultrasound to determine the optimum time point for simulation and delivery...
March 9, 2018: Curēus
https://www.readbyqxmd.com/read/29741773/phase-2-trial-of-neoadjuvant-chemotherapy-and-transoral-endoscopic-surgery-with-risk-adapted-adjuvant-therapy-for-squamous-cell-carcinoma-of-the-head-and-neck
#12
Jared M Weiss, Juneko E Grilley-Olson, Allison Mary Deal, Jose P Zevallos, Bhishamjit S Chera, Jennifer Paul, Mary Fleming Knowles, Dmitriy Usenko, Mark C Weissler, Samip Patel, David N Hayes, Trevor Hackman
BACKGROUND: The objective of this study was to demonstrate the feasibility and efficacy of induction chemotherapy, surgery, and pathology-guided adjuvant therapy to treat transorally resectable squamous head and neck cancer. METHODS: Patients had squamous head and neck cancer that was resectable by the transoral route and advanced-stage disease (American Joint Committee on Cancer stage III-IV, T3-T4 tumors, and/or positive lymph nodes). They received treatment with weekly carboplatin at an area under the curve of 2, plus paclitaxel 135 mg/m2 , and daily lapatinib 1000mg for 6 weeks followed by surgical resection...
May 9, 2018: Cancer
https://www.readbyqxmd.com/read/29731161/implications-of-improved-diagnostic-imaging-of-small-nodal-metastases-in-head-and-neck-cancer-radiotherapy-target-volume-transformation-and-dose-de-escalation
#13
REVIEW
Sven van den Bosch, Wouter V Vogel, Cornelis P Raaijmakers, Tim Dijkema, Chris H J Terhaard, Abrahim Al-Mamgani, Johannes H A M Kaanders
Diagnostic imaging continues to evolve, and now has unprecedented accuracy for detecting small nodal metastasis. This influences the tumor load in elective target volumes and subsequently has consequences for the radiotherapy dose required to control disease in these volumes. Small metastases that used to remain subclinical and were included in elective volumes, will nowadays be detected and included in high-dose volumes. Consequentially, high-dose volumes will more often contain low-volume disease. These target volume transformations lead to changes in the tumor burden in elective and "gross" tumor volumes with implications for the radiotherapy dose prescribed to these volumes...
May 3, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29729026/longevity-of-bond-strength-of-resin-cements-to-root-dentine-after-radiation-therapy
#14
P A Yamin, R D Pereira, F C Lopes, A M Queiroz, H F Oliveira, P C Saquy, M D Sousa-Neto
AIM: To evaluate the bond strength and adhesive interface between several resin cements and root dentine immediately and after 6 months of radiotherapy protocol. METHODOLOGY: Sixty maxillary canines were selected and randomly assigned to two groups (n=30): one group was not irradiated, and the other one was subjected to a cumulative radiation dose of 60 Gy. The teeth were sectioned to obtain roots with 16 mm length, and the canals were prepared with Reciproc system (R50) and filled using a lateral condensation technique with epoxy resin sealer...
May 4, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29727312/routine-adaptive-replanning-of-p16-positive-stage-n2b-oropharyngeal-cancer-quality-improvement-or-waste-of-time
#15
James H Zhu, Robert J Amdur, Bo Lu, Chihray Liu, Kathryn E Hitchcock, William M Mendenhall
PURPOSE/OBJECTIVE(S): To determine if routinely replanning patients treated for oropharyngeal cancer that is p16-positive and clinical neck stage N2b (AJCC 7th edition) is likely to result in dose changes that will improve patient outcomes to a meaningful degree. METHODS: In 10 consecutive patients treated with primary radiotherapy (RT) and concurrent weekly chemotherapy for p16-positive N2b oropharyngeal carcinoma, we prospectively evaluated dose changes from replanning for the final 4 or 2 weeks of RT of a 7-week RT program...
May 4, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29722594/stereotactic-body-radiotherapy-for-second-primary-lung-cancer-and-intra-parenchymal-lung-metastasis-in-patients-previously-treated-with-surgery-evaluation-of-indications-and-predictors-of-decreased-respiratory-function
#16
Takeaki Ishihara, Kazunari Yamada, Aya Harada, Haruhiro Yukiue, Masayuki Tanahashi, Hiroshi Niwa, Takashi Matsui, Koshi Yokomura, Yasuo Ejima, Ryohei Sasaki
BACKGROUND: The adaptation criteria for administration of stereotactic body radiotherapy (SBRT) to patients with lung cancer who previously underwent surgery and subsequently developed a second primary lung cancer (SPLC) or intra-parenchymal lung metastasis (IPLM) are controversial, unlike the criteria for repeat surgery. We aimed to evaluate the feasibility of SBRT for these patients. Factors associated with decreased respiratory function were also evaluated. MATERIAL AND METHODS: Sixty-nine patients with 89 lesions who underwent SBRT between 2008 and 2017 were analyzed...
May 3, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29707108/glioblastoma-specific-anti-tufm-nanobody-for-in-vitro-immunoimaging-and-cancer-stem-cell-targeting
#17
Neja Samec, Ivana Jovcevska, Jure Stojan, Alja Zottel, Mirjana Liovic, Michael P Myers, Serge Muyldermans, Jernej Šribar, Igor Križaj, Radovan Komel
Glioblastoma multiforme (GBM) is the most common and lethal form of brain tumor. The prognosis for patients remains poor, despite the combination of new preoperative and intraoperative neuroimaging, radical surgery, and recent advances in radiotherapy and chemotherapy. To improve GBM therapy and patient outcome, sustained drug delivery to glioma cells is needed, while minimizing toxicity to adjacent neurons and glia cells. This might be achieved through an anti-proteomic approach based on nanobodies, the single-domain antigen-binding fragments of heavy-chain antibodies of the camelid adaptive immune system...
April 3, 2018: Oncotarget
https://www.readbyqxmd.com/read/29706462/cost-effectiveness-analysis-of-stereotactic-body-radiotherapy-and-surgery-for-medically-operable-early-stage-non-small-cell-lung-cancer
#18
Adrien Paix, Georges Noel, Pierre-Emmanuel Falcoz, Pierre Levy
BACKGROUND: Projections estimate an increase of 50% of the incidence of lung cancer by 2030. Early-stage non-small cell lung cancer represented 19% of NSCLC cases diagnosed in the US between 2005 and 2011. There is rising evidence in favour of lung cancer screening, which will reduce the occurrence of later-stage lung cancers while raising the incidence of early-stage NSCLC. Current guidelines state that for early-stage NSCLC, surgical resection should be performed, and stereotactic body radiotherapy (SBRT) is an option for patients who are non-medically operable...
April 26, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29706107/adaptive-radiotherapy-in-head-and-neck-cancer-is-required-to-avoid-tumor-underdose
#19
J Castelli, A Simon, B Rigaud, E Chajon, J Thariat, K Benezery, E Vauleon, F Jegoux, O Henry, C Lafond, R de Crevoisier
No abstract text is available yet for this article.
April 28, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29699832/adaptive-radiotherapy-for-head-and-neck-cancers-fact-or-fallacy-to-improve-therapeutic-ratio
#20
Y Q Li, J S H Tan, J T S Wee, M L K Chua
Modern standards of precision radiotherapy, primarily driven by the technological advances of intensity modulation and image guidance, have led to increased versatility in radiotherapy planning and delivery. The ability to shape doses around critical normal organs, while simultaneously "painting" boost doses to the tumor have translated to substantial therapeutic gains in head and neck cancer patients. Recently, dose adaptation (or adaptive radiotherapy) has been proposed as a novel concept to enhance the therapeutic ratio of head and neck radiotherapy, facilitated in part by the onset of molecular and functional imaging...
April 23, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
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