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https://www.readbyqxmd.com/read/28433508/organs-at-risk-in-lung-sbrt
#1
REVIEW
F De Rose, D Franceschini, G Reggiori, A Stravato, P Navarria, A M Ascolese, S Tomatis, P Mancosu, M Scorsetti
Lung stereotactic body radiotherapy (SBRT) is an accurate and precise technique to treat lung tumors with high 'ablative' doses. Given the encouraging data in terms of local control and toxicity profile, SBRT has currently become a treatment option for both early stage lung cancer and lung oligometastatic disease in patients who are medically inoperable or refuse surgical resection. Dose-adapted fractionation schedules and ongoing prospective trials should provide further evidence of SBRT safety trying to reduce toxicities and complications...
April 19, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28428149/local-control-and-toxicity-of-adaptive-radiotherapy-using-weekly-ct-imaging-results-from-the-lartia-trial-in-stage-iii-nsclc
#2
Sara Ramella, Michele Fiore, Sonia Silipigni, Maria Cristina Zappa, Massimo Jaus, Antonio Maria Alberti, Paolo Matteucci, Elisabetta Molfese, Patrizia Cornacchione, Carlo Greco, Lucio Trodella, Edy Ippolito, Rolando Maria D'Angelillo
INTRODUCTION: Anatomical change of tumor during radiotherapy contributes to target missing. However, in case of tumor shrinkage adaptation of volume could results in an increased incidence of recurrences in the area of target reduction. This study aims to investigate the incidence of failure of adaptive approach and in particular the risk of local recurrence in the area excluded after replanning. METHODS: In this prospective study, LA-NSCLC patients treated with concomitant chemoradiation underwent weekly chest-CT simulation during treatment...
April 17, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28427523/combination-of-immune-checkpoint-inhibitors-and-radiotherapy-review-of-the-literature
#3
REVIEW
Alessandro Sindoni, Fabio Minutoli, Giorgio Ascenti, Stefano Pergolizzi
Literature experiences in cancer treatment usually deal with either targeting the tumour cell or the immune system, which often fail to reach the curative purposes in many solid tumours. On the other hand, one mechanism of radiation-induced tumour control is the activation of the adaptive immune system by tumour antigen release following radiotherapy. So, combining radiation therapy with immune checkpoint blockade treatment at the same time may represent a way to stimulate the adaptive immune system, with further amplification of immune responses reached through systemic immune checkpoint blockade...
May 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28425431/characterization-of-spatial-distortion-in-a-0-35t-mri-guided-radiotherapy-system
#4
John S Ginn, Nzhde Agazaryan, Minsong Cao, Umar Baharom, Daniel Low, Yingli Yang, Yu Gao, Peng Hu, Percy Lee, James Lamb
Spatial distortion results in image deformation that can degrade accurate targeting and dose calculations in MRI-guided adaptive radiotherapy. The authors present a comprehensive assessment of a 0.35T MRI-guided radiotherapy system's spatial distortion using two commercially-available phantoms with regularly spaced markers. Images of the spatial integrity phantoms were acquired using five clinical protocols on the MRI-guided radiotherapy machine with the radiotherapy gantry positioned at various angles. Software was developed to identify and localize all phantom markers using a template matching approach...
April 20, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28421162/r-ideal-a-framework-for-systematic-clinical-evaluation-of-technical-innovations-in-radiation-oncology
#5
Helena M Verkooijen, Linda G W Kerkmeijer, Clifton D Fuller, Robbert Huddart, Corinne Faivre-Finn, Marcel Verheij, Stella Mook, Arjun Sahgal, Emma Hall, Chris Schultz
The pace of innovation in radiation oncology is high and the window of opportunity for evaluation narrow. Financial incentives, industry pressure, and patients' demand for high-tech treatments have led to widespread implementation of innovations before, or even without, robust evidence of improved outcomes has been generated. The standard phase I-IV framework for drug evaluation is not the most efficient and desirable framework for assessment of technological innovations. In order to provide a standard assessment methodology for clinical evaluation of innovations in radiotherapy, we adapted the surgical IDEAL framework to fit the radiation oncology setting...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28419303/tumor-microtubes-convey-resistance-to-surgical-lesions-and-chemotherapy-in-gliomas
#6
Sophie Weil, Matthias Osswald, Gergely Solecki, Julia Grosch, Erik Jung, Dieter Lemke, Miriam Ratliff, Daniel Hänggi, Wolfgang Wick, Frank Winkler
Background: Primary and adaptive resistance against chemo- and radiotherapy, and local recurrence after surgery limit the benefits from these standard treatments in glioma patients. Recently we found that glioma cells can extend ultra-long membrane protrusions, "tumor microtubes" (TMs), for brain invasion, proliferation, and interconnection of single cells to a syncytium that is resistant to radiotherapy. We wondered whether TMs also convey resistance to the other two standard treatment modalities...
April 17, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28418763/long-term-follow-up-of-contemporary-treatment-in-early-stage-hodgkin-lymphoma-updated-analyses-of-the-german-hodgkin-study-group-hd7-hd8-hd10-and-hd11-trials
#7
Stephanie Sasse, Paul J Bröckelmann, Helen Goergen, Annette Plütschow, Horst Müller, Stefanie Kreissl, Carolin Buerkle, Sven Borchmann, Michael Fuchs, Peter Borchmann, Volker Diehl, Andreas Engert
Purpose Combined-modality treatment is widely considered the standard of care in early-stage Hodgkin lymphoma (HL), and treatment intensity has been reduced over the last years. Long-term follow-up is important to judge both efficacy and safety of the different therapies used. Patients and Methods We analyzed updated follow-up data on 4,276 patients treated within the German Hodgkin Study Group trials HD7 and HD10 for early-stage favorable HL and HD8 and HD11 for early-stage unfavorable HL between 1993 and 2003...
April 18, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28416263/the-keys-to-conservative-treatment-of-early-stage-squamous-cell-carcinoma-of-the-tonsillar-region
#8
O Laccourreye, P Castelnau-Marchand, F Rubin, C Badoual, P Halimi, P Giraud
To analyze the medical literature devoted to work-up, epidemiology, local control, survival, complications and sequelae after conservative treatment for early-stage squamous cell carcinoma of the tonsillar region. An analysis of the PubMed (1975-2016) database was performed using the following keywords and associations: "tonsil/tonsillar region/oropharynx" AND "squamous cell carcinoma" AND "early-stage (I-II; T1-2N0M0)" AND "radiation therapy/radiotherapy" OR "conservative surgery/oropharyngectomy/transoral surgery/radical tonsillectomy"...
April 14, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/28414799/comprehensive-evaluation-of-ten-deformable-image-registration-algorithms-for-contour-propagation-between-ct-and-cone-beam-ct-images-in-adaptive-head-neck-radiotherapy
#9
Xin Li, Yuyu Zhang, Yinghua Shi, Shuyu Wu, Yang Xiao, Xuejun Gu, Xin Zhen, Linghong Zhou
Deformable image registration (DIR) is a critical technic in adaptive radiotherapy (ART) for propagating contours between planning computerized tomography (CT) images and treatment CT/cone-beam CT (CBCT) images to account for organ deformation for treatment re-planning. To validate the ability and accuracy of DIR algorithms in organ at risk (OAR) contour mapping, ten intensity-based DIR strategies, which were classified into four categories-optical flow-based, demons-based, level-set-based and spline-based-were tested on planning CT and fractional CBCT images acquired from twenty-one head & neck (H&N) cancer patients who underwent 6~7-week intensity-modulated radiation therapy (IMRT)...
2017: PloS One
https://www.readbyqxmd.com/read/28410679/dual-energy-imaging-method-to-improve-the-image-quality-and-the-accuracy-of-dose-calculation-for-cone-beam-computed-tomography
#10
Kuo Men, Jianrong Dai, Xinyuan Chen, Minghui Li, Ke Zhang, Peng Huang
PURPOSE: To improve the image quality and accuracy of dose calculation for cone-beam computed tomography (CT) images through implementation of a dual-energy cone-beam computed tomography method (DE-CBCT), and evaluate the improvement quantitatively. METHODS: Two sets of CBCT projections were acquired using the X-ray volumetric imaging (XVI) system on a Synergy (Elekta, Stockholm, Sweden) system with 120kV (high) and 70kV (low) X-rays, respectively. Then, the electron density relative to water (relative electron density (RED)) of each voxel was calculated using a projection-based dual-energy decomposition method...
April 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28398879/parthenolide-selectively-sensitizes-prostate-tumor-tissue-to-radiotherapy-while-protecting-healthy-tissues-in-vivo
#11
Katherine L Morel, Rebecca J Ormsby, Eva Bezak, Christopher J Sweeney, Pamela J Sykes
Radiotherapy is widely used in cancer treatment, however the benefits can be limited by radiation-induced damage to neighboring normal tissues. Parthenolide (PTL) exhibits anti-inflammatory and anti-tumor properties and selectively induces radiosensitivity in prostate cancer cell lines, while protecting primary prostate epithelial cell lines from radiation-induced damage. Low doses of radiation have also been shown to protect from subsequent high-dose-radiation-induced apoptosis as well as DNA damage. These properties of PTL and low-dose radiation could be used to improve radiotherapy by killing more tumor cells and less normal cells...
March 3, 2017: Radiation Research
https://www.readbyqxmd.com/read/28398630/mitigating-differential-baseline-shifts-in-locally-advanced-lung-cancer-patients-using-an-average-anatomy-model
#12
Mehrsima Abdoli, Simon R van Kranen, Uros Stankovic, Maddalena M G Rossi, Jose S A Belderbos, Jan-Jakob Sonke
BACKGROUND AND PURPOSE: Differential baseline shifts between primary tumor and involved lymph nodes in locally advanced lung cancer patients compromise the accuracy of radiotherapy. The purpose of this study was to evaluate the performance of an average anatomy model (AAM) derived from repeat imaging and deformable registration to reduce these geometrical uncertainties. METHODS AND MATERIALS: An in-house implementation of a B-Spline deformable image registration (DIR) algorithm was first validated using three different validation approaches: 1) a circle method to test the consistency of the DIR, 2) fiducial marker target registration error, and 3) the recovery of a known deformation vector field (DVF)...
April 11, 2017: Medical Physics
https://www.readbyqxmd.com/read/28391984/-french-national-survey-on-incoming-phone-calls-in-oncology-departments
#13
Florence Joly, Aline Guillot, Yann-Alexandre Vano, Dominique Spaeth, Delphine Topart, Pascal Roffet, Rachid El Amarti, Ali Hasbini, Aude Fléchon
INTRODUCTION: Oral therapies have shifted the follow-up of patients with cancer from hospital to home. As a consequence, the number of incoming calls has increased. To understand the source, reasons, management and burden of calls, we underwent a French national survey. The objective was to describe the way calls are managed in oncology departments. METHODS: The study was a prospective survey in a representative sample of French oncology specialists using oral therapies...
April 6, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/28391003/surgery-alone-is-sufficient-therapy-for-children-and-adolescents-with-low-risk-synovial-sarcoma-a-joint-analysis-from-the-european-paediatric-soft-tissue-sarcoma-study-group-and-the-children-s-oncology-group
#14
Andrea Ferrari, Yueh-Yun Chi, Gian Luca De Salvo, Daniel Orbach, Bernadette Brennan, R Lor Randall, M Beth McCarville, Jennifer O Black, Rita Alaggio, Douglas S Hawkins, Gianni Bisogno, Sheri L Spunt
BACKGROUND: Multimodal risk-adapted treatment is used in paediatric protocols for synovial sarcoma (SS). Retrospective analyses suggest that low-risk SS patients can be safely treated with surgery alone, but no prospective studies have confirmed the safety of this approach. This analysis pooled data from the two prospective clinical trials to assess outcomes in SS patients treated with a surgery-only approach and to identify predictors of treatment failure. METHODS: Patients with localised SS enrolled on the European paediatric Soft tissue sarcoma Study Group (EpSSG) NRSTS2005 and on the Children Oncology Group (COG) ARST0332 trials, treated with surgery alone were eligible for this analysis...
April 6, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28380247/a-new-ct-reconstruction-technique-using-adaptive-deformation-recovery-and-intensity-correction-adric
#15
You Zhang, Jianhua Ma, Puneeth Iyenga, Yuncheng Zhong, Jing Wang
PURPOSE: Sequential same-patient CT images may involve deformation-induced and non-deformation-induced voxel intensity changes. An adaptive deformation recovery and intensity correction (ADRIC) technique was developed to improve the CT reconstruction accuracy, and to separate deformation from non-deformation-induced voxel intensity changes between sequential CT images. MATERIALS AND METHODS: ADRIC views the new CT volume as a deformation of a prior high-quality CT volume, but with additional non-deformation-induced voxel intensity changes...
April 5, 2017: Medical Physics
https://www.readbyqxmd.com/read/28376237/use-of-image-registration-and-fusion-algorithms-and-techniques-in-radiotherapy-report-of-the-aapm-radiation-therapy-committee-task-group-no-132
#16
Kristy K Brock, Sasa Mutic, Todd R McNutt, Hua Li, Marc L Kessler
Image registration and fusion algorithms exist in almost every software system that creates or uses images in radiotherapy. Most treatment planning systems support some form of image registration and fusion to allow the use of multimodality and time-series image data and even anatomical atlases to assist in target volume and normal tissue delineation. Treatment delivery systems perform registration and fusion between the planning images and the in-room images acquired during the treatment to assist patient positioning...
April 4, 2017: Medical Physics
https://www.readbyqxmd.com/read/28373101/aptamer-delivery-of-sirna-radiopharmaceutics-and-chemotherapy-agents-in-cancer
#17
Carlos E B de Almeida, Lais Nascimento Alves, Enrique T Paulino, Januário Bispo Cabral-Neto, Sotiris Missailidis
Aptamers are oligonucleotide reagents with high affinity and specificity, which among other therapeutic and diagnostic applications have the capability of acting as delivery agents. Thus, aptamers are capable of carrying small molecules, nanoparticles, radiopharmaceuticals or fluorescent agents as well as nucleic acid therapeutics specifically to their target cells. In most cases, the molecules may possess interesting therapeutic properties, but their lack of specificity for a particular cell type, or ability to internalise in such a cell, hinders their clinical development, or cause unwanted side effects...
March 31, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28365830/optimal-therapy-for-early-stage-hodgkin-s-lymphoma-risk-adapting-response-adapting-and-role-of-radiotherapy
#18
REVIEW
Andrea Riccardo Filippi, Mario Levis, Rahul Parikh, Bradford Hoppe
PURPOSE OF REVIEW: The aim of this article is to discuss the current role of radiotherapy (RT) for early-stage Hodgkin's lymphoma (HL) in the context of risk-adapted and response-adapted treatment strategy, and describe changes in RT technical approach. RECENT FINDINGS: In low-risk patients, RT could be omitted but, at the price of a lower progression-free survival, and its role is still debated. Ongoing trials are combining new agents with chemotherapy alone or response-adapted combined modality therapy, and results are awaited...
May 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/28365084/perianal-synovial-sarcoma-treated-postoperatively-with-iodine-125-brachytherapy-technical-details
#19
Susan Tovey, Clare Stannard, Gerrie Maree, Robin Hiscock, Charlie Thomson, Eugenio Panieri, Paul Goldberg
PURPOSE: A 23-year-old lady had an incompletely excised perianal sarcoma. Brachytherapy as the sole treatment, rather than further surgery or external beam radiotherapy, was considered to be the best option with the least morbidity. METHODS AND MATERIALS: Although brachytherapy techniques with iridium-192 for anal and rectal carcinoma are well described using a perianal template, the size of the template was not suitable for a two-plane implant that needed to be in situ for about 4 days...
March 29, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28358667/optimizing-sabr-delivery-for-synchronous-multiple-lung-tumors-using-volumetric-modulated-arc-therapy
#20
Hilâl Tekatli, Shyama U Tetar, Timothy K Nguyen, Andrew Warner, Wilko F Verbakel, David A Palma, Max Dahele, Stewart Gaede, Cornelis Haasbeek, Femke O Spoelstra, Patricia F de Haan, Ben J Slotman, Suresh Senan
BACKGROUND: Volumetric-modulated arc therapy (VMAT) delivery for stereotactic ablative radiotherapy (SABR) of multiple lung tumors allows for faster treatments. We report on clinical outcomes and describe a general approach for treatment planning. MATERIAL AND METHODS: Patients undergoing multi iso-center VMAT-based SABR for ≥2 lung lesions between 2009 and 2014 were identified from the VU University Medical Center and London Health Sciences Centre. Patients were eligible if the start date of the SABR treatment for the different lesions was within a time range of 30 days...
April 2017: Acta Oncologica
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