keyword
https://read.qxmd.com/read/37753548/stability-assessment-of-anti-bacterial-antibodies-in-immunoglobulin-g-depleted-serum-with-validated-immunoassays
#1
JOURNAL ARTICLE
Andrea Engelmaier, Harald A Butterweck, Alfred Weber
Aim: To investigate the stability of the anti-pneumococcal (PCP) and anti-haemophilus type B (Hib) immunoglobulins (IgGs) in human IgG-depleted serum samples frozen at -20°C. Materials & methods: Modified commercially available immunoassays (ELISAs) were bioanalytically validated. These ELISAs were used to measure levels of the two anti-bacterial IgG in samples kept at -20°C for up to 15 months. Human IgG-depleted serum was spiked with GAMMAGARD Liquid to obtain those samples. Results: Both ELISAs passed the validation test...
September 27, 2023: Immunotherapy
https://read.qxmd.com/read/36977996/a-case-report-of-an-atypical-haemolytic-uremic-syndrome-in-pregnancy-something-wicked-this-way-comes
#2
JOURNAL ARTICLE
Stefano Catarci, Bruno Antonio Zanfini, Mariangela Di Muro, Emanuele Capone, Luciano Frassanito, Maria Teresa Santantonio, Gaetano Draisci
BACKGROUND: Atypical Haemolytic Uremic Syndrome is an acute life-threatening condition, characterized by the clinical triad of microangiopathic hemolytic anaemia, thrombocytopenia, kidney injury. Management of pregnants affected by Atypical Haemolytic Uremic Syndrome can be a serious concern for obstetric anesthesiologist in the delivery room and in the intensive care unit. CASE PRESENTATION: A 35-year-old primigravida with a monochorionic diamniotic twin pregnancy, presented with an acute haemorrhage due to retained placenta after elective caesarean section and underwent surgical exploration...
March 28, 2023: BMC Anesthesiology
https://read.qxmd.com/read/35403683/defective-monocyte-enzymatic-function-and-an-inhibitory-immune-phenotype-in-hiv-exposed-uninfected-african-infants-in-the-era-of-antiretroviral-therapy
#3
JOURNAL ARTICLE
Louise Afran, Kondwani C Jambo, Wilfred Nedi, David J C Miles, Anmol Kiran, Dominic H Banda, Ralph Kamg'ona, Dumizulu Tembo, Annette Pachnio, Eleni Nastouli, Brigit Ferne, Henry C Mwandumba, Paul Moss, David Goldblatt, Sarah Rowland-Jones, Adam Finn, Robert S Heyderman
BACKGROUND: HIV-Exposed Uninfected (HEU) infants are a rapidly expanding population in sub-Saharan Africa, highly susceptible to encapsulated bacterial disease in the first year of life. The mechanism of this increased risk is still poorly understood. We investigated if HIV-exposure dysregulates HEU immunity, vaccine-antibody production and human herpes virus (HHV) amplify this effect. METHODS: 34 HIV-infected and 44 HIV-uninfected pregnant women were recruited into the birth cohort, followed up to 6 weeks of age; and 43 HIV-infected and 61 HIV-uninfected mother-infant pairs into a longitudinal infant cohort, at either: 5-7 to 14-15; or 14-15 to 18-23 weeks of age...
April 11, 2022: Journal of Infectious Diseases
https://read.qxmd.com/read/33557365/trough-concentrations-of-specific-antibodies-in-primary-immunodeficiency-patients-receiving-intravenous-immunoglobulin-replacement-therapy
#4
JOURNAL ARTICLE
Ori Hassin, Yahya Abu Freih, Ran Hazan, Atar Lev, Keren S Zrihen, Raz Somech, Arnon Broides, Amit Nahum
Immunoglobulin replacement therapy is a mainstay therapy for patients with primary immunodeficiency (PID). The content of these preparations was studied extensively. Nevertheless, data regarding the effective specific antibodies content (especially in the nadir period), and, in different groups of PID patients is limited. We studied trough IgG concentrations as well as anti-Pneumococcus, anti-Haemophilus influenzae b, anti-Tetanus, and anti-Measles antibody concentrations in 17 PID patients receiving intravenous immunoglobulin (IVIg) compared with healthy controls matched for age and ethnicity...
February 4, 2021: Journal of Clinical Medicine
https://read.qxmd.com/read/33356678/utility-of-immunology-microbiology-and-helminth-investigations-in-clinical-assessment-of-severe-asthma
#5
JOURNAL ARTICLE
Andrew Singer, F Runa Ali, Simon Quantrill, Nathan North, Mike Stevens, Jonathan Lambourne, Sofia Grigoriadou, Paul E Pfeffer
Objective: Systematic assessment of patients with potential severe asthma is key to identification of treatable traits and optimal management. Assessment of anti-microbial immune function is part of that assessment at many centres although there is little evidence-base on its added value in clinical assessment of this patient group. As part of reviewing our local pathway we have retrospectively reviewed these tests in 327 consecutive referrals to our severe asthma service, in an evaluation to describe the utility of these tests and allow refinement of the local guideline for patient assessment...
December 23, 2020: Journal of Asthma
https://read.qxmd.com/read/31514307/anti-haemophilus-activity-of-selected-essential-oils-detected-by-tlc-direct-bioautography-and-biofilm-inhibition
#6
JOURNAL ARTICLE
Viktória Lilla Balázs, Barbara Horváth, Erika Kerekes, Kamilla Ács, Béla Kocsis, Adorján Varga, Andrea Böszörményi, Dávid U Nagy, Judit Krisch, Aleksandar Széchenyi, Györgyi Horváth
Essential oils (EOs) are becoming increasingly popular in medical applications because of their antimicrobial effect. Direct bioautography (DB) combined with thin layer chromatography (TLC) is a screening method for the detection of antimicrobial compounds in plant extracts, for example, in EOs. Due to their lipophilic character, the common microbiological assays (etc. disk diffusion) could not provide reliable results. The aim of this study was the evaluation of antibacterial and anti-biofilm properties of the EO of cinnamon bark, clove, peppermint, thyme, and their main components against Haemophilus influenzae and H...
September 11, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/30958343/circulating-innate-and-adaptive-immunity-against-anti-haemophilus-influenzae-type-b
#7
REVIEW
Adi E Zarei, Mustafa H Linjawi, Elrashdy M Redwan
Haemophilus influenzae type b (Hib) are one of most dangerous microbes that occupies the paediatric nasopharyngeal as a commensal opportunistic bacterium, which may lead to meningitis in uncontrolled infection. Colonisation of pharyngeal tissues is the starting point for most H. influenzae infections, which may develop into invasive diseases, such meningitis. The vaccination against Hib in specific, as well as against most of vaccines preventable diseases; in general, play a major role in reducing children (< 5 years old) Hib meningitis from 57/100,000 to the lowest known Hib meningitis incidents in the history...
2019: Human Antibodies
https://read.qxmd.com/read/29522908/pharmacokinetics-of-a-novel-human-intravenous-immunoglobulin-10-in-patients-with-primary-immunodeficiency-diseases-analysis-of-a-phase-iii-multicentre-prospective-open-label-study
#8
MULTICENTER STUDY
Isaac R Melamed, Michael Borte, Laurenz Trawnicek, Ai-Lan Kobayashi, Roger H Kobayashi, Alan Knutsen, Sudhir Gupta, William Smits, Anna Pituch-Noworolska, Magdalena Strach, Grazyna Pulka, Hans D Ochs, James N Moy
Intravenous immunoglobulin (IVIG) therapy is commonly used to treat patients with primary antibody deficiency. This prospective, open-label, non-randomised, multicentre, phase III trial investigated the pharmacokinetics of a new 10% liquid IVIG product (panzyga®; Octapharma) in 51 patients aged 2-75 years with common variable immunodeficiency (n = 43) or X-linked agammaglobulinaemia (n = 8). Patients were treated with IVIG 10% every 3 (n = 21) or 4 weeks (n = 30) at a dose of 200-800 mg/kg for 12 months...
June 15, 2018: European Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/27639067/early-intravenous-immunoglobulin-replacement-in-hypogammaglobulinemic-heart-transplant-recipients-results-of-a-clinical-trial
#9
JOURNAL ARTICLE
Elizabeth Sarmiento, Pablo Diez, Mauricio Arraya, Maria Jaramillo, Leticia Calahorra, Juan Fernandez-Yañez, Jesus Palomo, Iago Sousa, Javier Hortal, Jose Barrio, Roberto Alonso, Patricia Muñoz, Joaquin Navarro, Jose Vicario, Eduardo Fernandez-Cruz, Javier Carbone
BACKGROUND: Immunoglobulin G (IgG) hypogammaglobulinemia (HGG) is a risk factor for development of severe infections after heart transplantation. We performed a clinical trial to preliminarily evaluate the efficacy and safety of early administration of intravenous immunoglobulin (IVIG) for prevention of severe infection in heart recipients with post-transplant IgG HGG. METHODS: Twelve heart recipients with IgG HGG detected in a screening phase of the clinical trial (IgG <500 mg/dL) were recruited...
December 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/27187042/ige-anti-haemophilus-influenzae-type-b-hib-antibodies-detected-in-serum-of-hib-vaccinated-asthmatic-and-non-asthmatic-pediatric-patients
#10
JOURNAL ARTICLE
Tamar A Smith-Norowitz, Tehila A Saadia, Natalie Banniettis, Yitzchok M Norowitz, Rauno Joks, Margaret R Hammerschlag, Helen G Durkin, Stephan Kohlhoff
BACKGROUND: Haemophilus influenzae type b (Hib) bacterium causes severe illness in infants and children, but has largely been eliminated by introducing a universal Hib conjugate vaccine. While effects of certain vaccinations on atopic disease have been studied, little is known about the relationship between Hib vaccination and diseases of altered immunoglobulin E (IgE) regulation (asthma or atopy). As such, it is necessary to provide more evidence concerning Hib vaccination as a possible risk factor for atopic disease...
April 2018: Minerva Pediatrica
https://read.qxmd.com/read/26923083/comparison-of-the-immunogenicity-and-safety-of-pentavalent-vaccine-quinvaxem-in-a-compact-prefilled-auto-disabled-cpad-injection-system-versus-single-dose-vials-in-healthy-infants-a-phase-3-open-label-randomized-parallel-group-non-inferiority-study
#11
RANDOMIZED CONTROLLED TRIAL
Maria Rosario Z Capeding, Edison Alberto, Amanda Versteilen, Martina Rauscher, Partha Bagchi, Patricia Ibarra de Palacios
OBJECTIVE: To evaluate non-inferiority of three doses of Quinvaxem in a compact prefilled auto-disabled (cPAD) injection system versus Quinvaxem in a single-dose vial administered with conventional syringe in terms of seroconversion/seroprotection rates for all antibodies (anti-hepatitis B (HB), anti-Haemophilus influenzae type b polyribosylribitol phosphate (Hib PRP), anti-diphtheria, anti-tetanus, anti-Bordetella pertussis) at 1 month after primary vaccination. METHODS: Four hundred healthy infants aged 42-65 days were randomized (1:1) to receive Quinvaxem in cPAD or single-dose vial at 6, 10, and 12 weeks of age...
May 2016: International Journal of Infectious Diseases: IJID
https://read.qxmd.com/read/26844500/invasive-haemophilus-influenzae-serotype-f-case-reports-in-mazovia-province-poland
#12
JOURNAL ARTICLE
Anna Golebiewska, Alicja Kuch, Agnieszka Gawrońska, Piotr Albrecht, Anna Skoczyńska, Andrzej Radzikowski, Ewa Kutylowska, Wojciech Feleszko
After successful introduction of anti-Haemophilus influenzae (Hi) serotype b vaccination program in Poland, invasive non-b or nontypeable H. influenzae infections have been reported more frequently alike in other countries all over the world. In this paper, we report 2 cases of H. influenzae serotype f (Hif) meningitis with severe clinical presentations which are rarely seen in previously healthy children.The first case is a 6-year-old girl who was admitted to pediatric ward with signs of meningitis. Laboratory tests confirmed bacteremic meningitis caused by Hif...
February 2016: Medicine (Baltimore)
https://read.qxmd.com/read/26372451/five-year-antibody-persistence-and-safety-after-a-single-dose-of-combined-haemophilus-influenzae-type-b-neisseria-meningitidis-serogroup-c-tetanus-toxoid-conjugate-vaccine-in-haemophilus-influenzae-type-b-primed-toddlers
#13
RANDOMIZED CONTROLLED TRIAL
Robert Booy, Terry Nolan, Graham Reynolds, Peter Richmond, Michael Nissen, Helen Marshall, Tanya Stoney, Marie Van Der Wielen, Devayani Kolhe, Jacqueline M Miller
BACKGROUND: Antibody persistence is evaluated in healthy Australian children 4 and 5 years postvaccination with a single dose of combined Haemophilus influenzae type b-Neisseria meningitidis serogroup C tetanus toxoid conjugate vaccine (Hib-MenC-TT) compared with separately administered Hib-TT and MenC-CRM197 vaccines (Hib + MCC). METHODS: This is another follow-up of a phase III, open, randomized, controlled study (NCT00326118), in which 433 Hib-primed but MenC naïve toddlers aged 12-18 months were randomized 3:1 to receive Hib-MenC-TT or Hib + MCC vaccines...
December 2015: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/26328602/salivary-functional-antibody-secretion-is-reduced-in-older-adults-a-potential-mechanism-of-increased-susceptibility-to-bacterial-infection-in-the-elderly
#14
JOURNAL ARTICLE
Jennifer L J Heaney, Anna C Phillips, Douglas Carroll, Mark T Drayson
BACKGROUND: Bacterial infections in the elderly are common and associated with high morbidity and mortality, with pneumonia the second commonest cause of death. Reductions in antibodies against specific bacterial antigens in saliva and serum could contribute to infection risk in older adults, although they have yet to be examined in relation to age. METHOD: IgG, IgA and IgM antibody levels in paired saliva and serum samples were measured against 12 pneumococcal, 4 meningococcal and haemophilus polysaccharide antigens and diphtheria and tetanus toxoids in healthy younger (n = 28, 21-34 years) and older (n = 44, 60-80 years) adults...
December 2015: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/26308112/concomitant-use-of-vaqta-with-pedvaxhib-and-infanrix-in-12-to-17-month-old-children
#15
RANDOMIZED CONTROLLED TRIAL
Maria Petrecz, Keith P Ramsey, Jon E Stek, Jason C Martin, Stephanie O Klopfer, Barbara Kuter, Florian P Schödel, Andrew W Lee
Open-label, multicenter, randomized study (NCT00289913) evaluated immunogenicity, safety, and tolerability of Vaqta (hepatitis A vaccine) administered with PedvaxHIB (Haemophilus b conjugate vaccine [Meningococcal protein conjugate]) & Infanrix (diphtheria/tetanus/acellular pertussis vaccine) in healthy, 15-month-old children. Five groups were evaluated: Group 1 received Vaqta/Infanrix PedvaxHIB on Day-1 and Vaqta at Week-24; Group 2 received Infanrix PedvaxHIB on Day-1, Vaqta at Week-4, and Vaqta at Week-28; Group 3 received Vaqta/PedvaxHIB on Day-1 and Vaqta Week-24; Group 4 received PedvaxHIB on Day-1, Vaqta at Week-4, and Vaqta at Week-28; and Group 5 (safety only) received Vaqta on Day-1 and Vaqta at Week-24...
2016: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/26212006/phid-cv-induces-anti-protein-d-antibodies-but-does-not-augment-pulmonary-clearance-of-nontypeable-haemophilus-influenzae-in-mice
#16
JOURNAL ARTICLE
Matthew K Siggins, Simren K Gill, Paul R Langford, Yanwen Li, Shamez N Ladhani, John S Tregoning
BACKGROUND: A recently-licensed 10-valent pneumococcal conjugate vaccine (PHiD-CV; Synflorix, GSK) uses Protein D from Haemophilus influenzae as a carrier protein. PHiD-CV therefore has the potential to provide additional protection against nontypeable H. influenzae (NTHi). NTHi frequently causes respiratory tract infections and is associated with significant morbidity and mortality worldwide and there is currently no vaccine. METHODS: We developed mouse models of NTHi infection and influenza/NTHi superinfection...
September 11, 2015: Vaccine
https://read.qxmd.com/read/26207607/platelet-activating-factor-receptor-gateway-for-bacterial-chronic-airway-infection-in-chronic-obstructive-pulmonary-disease-and-potential-therapeutic-target
#17
REVIEW
Shakti Dhar Shukla, Sukhwinder Singh Sohal, Ronan F O'Toole, Mathew Suji Eapen, Eugene Haydn Walters
The authors established that cigarette smoke increases airway epithelial platelet activating factor receptor (PAFr) expression and that PAFr is markedly up-regulated in the lungs of chronic obstructive pulmonary disease (COPD) patients. Crucially, PAFr is used by the two key bacterial species involved in chronic infection and acute exacerbations in COPD, that is, Streptococcus pneumoniae and Haemophilus influenzae, as a receptor for lung epithelial colonization. The cognate adhesin of PAFr, phosphorylcholine (ChoP), in the cell wall of these bacterial species may be a key effector that underpins host colonization...
August 2015: Expert Review of Respiratory Medicine
https://read.qxmd.com/read/26202987/phosphocholine-modified-macromolecules-and-canonical-nicotinic-agonists-inhibit-atp-induced-il-1%C3%AE-release
#18
JOURNAL ARTICLE
Andreas Hecker, Mira Küllmar, Sigrid Wilker, Katrin Richter, Anna Zakrzewicz, Srebrena Atanasova, Verena Mathes, Thomas Timm, Sabrina Lerner, Jochen Klein, Andreas Kaufmann, Stefan Bauer, Winfried Padberg, Wolfgang Kummer, Sabina Janciauskiene, Martin Fronius, Elke K H Schweda, Günter Lochnit, Veronika Grau
IL-1β is a potent proinflammatory cytokine of the innate immune system that is involved in host defense against infection. However, increased production of IL-1β plays a pathogenic role in various inflammatory diseases, such as rheumatoid arthritis, gout, sepsis, stroke, and transplant rejection. To prevent detrimental collateral damage, IL-1β release is tightly controlled and typically requires two consecutive danger signals. LPS from Gram-negative bacteria is a prototypical first signal inducing pro-IL-1β synthesis, whereas extracellular ATP is a typical second signal sensed by the ATP receptor P2X7 that triggers activation of the NLRP3-containing inflammasome, proteolytic cleavage of pro-IL-1β by caspase-1, and release of mature IL-1β...
September 1, 2015: Journal of Immunology
https://read.qxmd.com/read/26169732/glycans-as-vaccine-antigens-and-adjuvants-immunological-considerations
#19
REVIEW
Stephanie Zimmermann, Bernd Lepenies
Carbohydrates can be found on the cell surface of nearly every cell ranging from bacteria to fungi right up to mammalian cells. Carbohydrates and their interactions with carbohydrate-binding proteins play crucial roles in multiple biological processes including immunity, homeostasis, cellular communication, cell migration, and the regulation of serum glycoprotein levels. In the last decades, the interest in exploiting the biological activity of glycans as vaccine components has considerably increased. On the one hand, carbohydrates display epitopes to generate protective antibodies against pathogen-derived cell wall structures and on the other hand, glycans have the potential to stimulate the immune system; thus they can act as potent vaccine adjuvants...
2015: Methods in Molecular Biology
https://read.qxmd.com/read/26039632/il-17a-and-the-promotion-of-neutrophilia-in-acute-exacerbation-of-chronic-obstructive-pulmonary-disease
#20
JOURNAL ARTICLE
Abraham B Roos, Sanjay Sethi, Jake Nikota, Catherine T Wrona, Michael G Dorrington, Caroline Sandén, Carla M T Bauer, Pamela Shen, Dawn Bowdish, Christopher S Stevenson, Jonas S Erjefält, Martin R Stampfli
RATIONALE: Nontypeable Haemophilus influenzae (NTHi) causes acute exacerbation of chronic obstructive pulmonary disease (AECOPD). IL-17A is central for neutrophilic inflammation and has been linked to COPD pathogenesis. OBJECTIVES: We investigated whether IL-17A is elevated in NTHi-associated AECOPD and required for NTHi-exacerbated pulmonary neutrophilia induced by cigarette smoke. METHODS: Experimental studies with cigarette smoke and NTHi infection were pursued in gene-targeted mice and using antibody intervention...
August 15, 2015: American Journal of Respiratory and Critical Care Medicine
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