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Bioresorbable scaffold

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https://www.readbyqxmd.com/read/29777297/optical-coherence-tomography-in-stemi-with-bioresorbable-scaffold-possible-cause-of-coronary-flow-impairment-a-sub-study-from-the-prague-19-trial
#1
Marco Loffi, Petr Tousek, Tomas Budesinsky, Libor Lisa, Andrea Santangelo, Petr Widimsky, Viktor Kocka
This study assessed the Optical Coherence Tomography (OCT) impact on the coronary flow in ST-elevation myocardial infarction (STEMI) after bioresorbable scaffold implantation. Only few data about OCT use in STEMI are available and coronary flow before and after OCT is not well studied yet. 54 patients with OCT performed at the end of procedure from the Prague 19 trial were selected and coronary flow was evaluated as TIMI frame count (TFC) before and just after OCT. Significant increase in TIMI frame count after OCT [from 9...
May 18, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29774520/implantation-of-bioresorbable-scaffolds-under-guidance-of-optical-coherence-tomography-feasibility-and-pilot-clinical-results-of-a-systematic-protocol
#2
Juan Luis Gutiérrez-Chico, Carlos Cortés, Michele Schincariol, Ula Limon, Meric Yalcinli, María-Alexandra Durán-Cortés, Milosz Jaguszewski
BACKGROUND: We hypothesise that a comprehensive optical coherence tomography (OCT)-guided implantation protocol for bioresorbable scaffolds (BRS) might improve expansion and apposition, thus translating into better clinical outcomes, particularly reducing thrombotic events. METHODS: Patients considered suitable for BRS therapy in de novo coronary lesions underwent OCT. The predominant type of plaque was classified as lipidic, fibrous or calcific, undergoing tailored plaque preparation accordingly...
May 18, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/29756198/bioresorbable-vascular-scaffolds-for-a-long-diffuse-coronary-lesion-insights-from-optical-coherence-tomography-at-25-month-follow-up
#3
Sandeep Basavarajaiah, Toru Naganuma, Richard Watkin
No abstract text is available yet for this article.
2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29743023/three-years-outcomes-of-diabetic-patients-treated-with-coronary-bioresorbable-scaffolds
#4
Remzi Anadol, Katharina Schnitzler, Liv Lorenz, Melissa Weissner, Helen Ullrich, Alberto Polimeni, Thomas Münzel, Tommaso Gori
BACKGROUND: Diabetes is among the strongest predictors of outcome after coronary artery stenting and the incidence of negative outcomes is still high in this specific group. Data of long-term outcomes comparing diabetic patients with non-diabetic patients treated with bioresorbable scaffolds are still incomplete. This work evaluates the long-term outcomes after implantation of a coronary bioresorbable scaffold (BRS) in diabetic patients compared to non-diabetics. METHODS: Patients who received at least one Absorb BRS in the time of May 2012 to December 2014 were enrolled into this single-center registry...
May 10, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29742143/mid-term-outcomes-of-the-absorb-bvs-versus-second-generation-des-a-systematic-review-and-meta-analysis
#5
Cordula M Felix, Victor J van den Berg, Sanne E Hoeks, Jiang Ming Fam, Mattie Lenzen, Eric Boersma, Peter C Smits, Patrick W Serruys, Yoshinobu Onuma, Robert Jan M van Geuns
BACKGROUND: Bioresorbable Vascular Scaffolds (BVS) were introduced to overcome some of the limitations of drug-eluting stent (DES) for PCI. Data regarding the clinical outcomes of the BVS versus DES beyond 2 years are emerging. OBJECTIVE: To study mid-term outcomes. METHODS: We searched online databases (PubMed/Medline, Embase, CENTRAL), several websites, meeting presentations and scientific session abstracts until August 8th, 2017 for studies comparing Absorb BVS with second-generation DES...
2018: PloS One
https://www.readbyqxmd.com/read/29741484/comparison-of-acute-thrombogenicity-for-magnesium-versus-stainless-steel-stents-in-a-porcine-arteriovenous-shunt-model
#6
Michael J Lipinski, Eduardo Acampado, Qi Cheng, Lila Adams, Sho Torii, Jiaxiang Gai, Rebecca Torguson, David G Hellinga, Michael Joner, Claus Harder, Philine Zumstein, Aloke V Finn, Frank D Kolodgie, Renu Virmani, Ron Waksman
Aims The aetiology for reduced thrombogenicity of the Magmaris resorbable magnesium scaffold (RMS) when compared with the Absorb bioresorbable vascular scaffold remains unclear. We therefore investigated whether the Magmaris RMS has platelet-repelling properties by comparing its acute thrombogenicity with an equivalent stainless steel stent in an arteriovenous shunt model. Methods and Results An ex vivo porcine carotid jugular arteriovenous shunt was established and connected to Sylgard tubing containing the Magmaris RMS with sirolimus-eluting PLLA coating and an equivalent 316L stainless steel stent with sirolimus-eluting PLLA coating...
May 8, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29732926/imaging-guided-pre-dilatation-stenting-post-dilatation-ipsp-a-protocolized-approach-highlighting-the-importance-of-intravascular-imaging-for-implantation-of-bioresorbable-scaffolds
#7
Ziad A Ali, Keyvan Karimi Galougahi, Richard Shlofmitz, Akiko Maehara, Gary S Mintz, Alexandre Abizaid, Daniel Chamié, Jonathan Hill, Patrick W Serruys, Yoshinobu Onuma, Gregg W Stone
The advent of the fully bioresorbable vascular scaffold (BVS) is the latest step in a series of advancements in the design of intracoronary stents over the past few decades. The novelty of this technology is in providing temporary vessel scaffolding and local antiproliferative therapy to prevent neointimal hyperplasia after percutaneous coronary intervention followed by gradual resorption of the scaffold to restore the native vessel anatomy and physiology-a process termed vascular reparative therapy. Areas covered: The first generation of BVS has not been able to fully match the high benchmark in safety and efficacy set by contemporary metallic drug-eluting stents...
May 7, 2018: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29699747/meta-analysis-comparing-outcomes-after-everolimus-eluting-bioresorbable-vascular-scaffolds-versus-everolimus-eluting-metallic-stents-in-patients-with-acute-coronary-syndromes
#8
Roberta De Rosa, Angelo Silverio, Attilio Varricchio, Giuseppe De Luca, Marco Di Maio, Ilaria Radano, Marta Belmonte, Maria Carmen De Angelis, Elisabetta Moscarella, Rodolfo Citro, Federico Piscione, Gennaro Galasso
Acute coronary syndromes (ACS) may represent an intriguing clinical scenario for implantation of bioresorbable vascular scaffold (BRS). Nevertheless, the knowledge about the performance of these devices in patients with ACS is limited. Therefore, we performed a meta-analysis of clinical studies aiming to assess the safety and efficacy of everolimus-eluting-BRS versus everolimus-eluting-metallic stents (EES) in ACS patients undergoing percutaneous coronary intervention. Six studies enrolling 2,318 patients were included and analyzed for the risk of primary safety outcome (stent or scaffold thrombosis [ST/ScT]), primary efficacy outcome (target lesion revascularisation [TLR]), and secondary outcomes (myocardial infarction, cardiac death, all-cause death)...
March 27, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29699615/long-term-assessment-of-bioresorbable-coronary-scaffolds-disappearing-stents-reappearing-atherosclerosis
#9
EDITORIAL
Stephan Windecker, Raffaele Piccolo, Yasushi Ueki
No abstract text is available yet for this article.
May 1, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29699614/neoatherosclerosis-5-years-after-bioresorbable-vascular-scaffold-implantation
#10
Noriaki Moriyama, Koki Shishido, Yutaka Tanaka, Shohei Yokota, Takahiro Hayashi, Hirokazu Miyashita, Tatsuya Koike, Hiroaki Yokoyama, Takuma Takada, Takashi Nishimoto, Tomoki Ochiai, Kazuki Tobita, Futoshi Yamanaka, Shingo Mizuno, Masato Murakami, Saeko Takahashi, Shigeru Saito
BACKGROUND: Data regarding neoatherosclerosis after everolimus-eluting bioresorbable vascular scaffold (BVS) (ABSORB BVS Rev. 1.1, Abbott Vascular, Santa Clara, California) implantation are limited. OBJECTIVES: This study investigated the findings of neoatherosclerosis at 5 years after BVS 1.1 implantation by using multi-imaging modalities, including optical coherence tomography (OCT). METHODS: Patients included in the ABSORB EXTEND (ABSORB EXTEND Clinical Investigation) trial at Shonan Kamakura General Hospital underwent OCT at baseline after the index procedure and at 1 and 5 years...
May 1, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29696533/tirofiban-positively-regulates-%C3%AE-1-integrin-and-favours-endothelial-cell-growth-on-polylactic-acid-biopolymer-vascular-scaffold-bvs
#11
Arturo Giordano, Simona Romano, Nicola Corcione, Giacomo Frati, Giuseppe Biondi Zoccai, Paolo Ferraro, Stefano Messina, Stefano Ottolini, Maria Fiammetta Romano
An unexpectedly high incidence of thrombosis in patients that received the polylactic acid bioresorbable vascular scaffold (BVS) suggests a delayed/incomplete endothelial repair with this stent. The anti-platelet agent tirofiban stimulates endothelial cell migration and proliferation, mediated by VEGF production. We investigated the tirofiban effect on the migration and adhesion of endothelial cells to BVS, in vitro. We performed human umbilical endothelial cell (HUVEC) cultures in the presence of BVS. Tirofiban, similarly to VEGF, increased the ability of HUVEC to grow on the vascular scaffold, compared to unstimulated or abciximab-treated cells...
April 25, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29691092/bioresorbable-vascular-scaffold-restenosis-treated-with-sirolimus-eluting-balloon-optical-coherence-tomography-findings
#12
Javier Cuesta, Marcos García-Guimaraes, Teresa Bastante, Fernando Rivero, Ramón Maruri, Fernando Alfonso
No abstract text is available yet for this article.
April 21, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29688175/implantation-techniques-pre-dilatation-sizing-and-post-dilatation-and-the-incidence-of-scaffold-thrombosis-and-revascularization-in-lesions-treated-with-an-everolimus-eluting-bioresorbable-vascular-scaffold-insights-from-the-aida-trial
#13
Ruben Yannick G Tijssen, Robin P Kraak, Joelle Elias, Ivo M van Dongen, Deborah Nancy Kalkman, Martina Nassif, Yohei Sotomi, Taku Asano, Yuki Katagiri, Carlos Collet, Jan J Piek, Jose P S Henriques, Robbert J de Winter, Jan G Tijssen, Yoshinobu Onuma, Patrick W Serruys, Joanna J Wykrzykowska
AIMS: Absorb bioresorbable vascular scaffold (Absorb BVS) specific implantation strategies have been proposed to optimize outcomes. We analyzed whether the occurrence of definite scaffold thrombosis (ScT) and target lesion revascularization (TLR) in Absorb-treated AIDA patients was influenced by scaffold implantation techniques. METHODS AND RESULTS: Absorb BVS implantation in 1074 lesions was graded according to definitions of optimal implantation based on pre-dilatation, sizing, and post-dilatation (PSP)...
April 24, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29678390/bioresorbable-vascular-scaffolds-time-to-absorb-past-lessons-or-fade-away
#14
Aurélien de Pommereau, Quentin de Hemptinne, Olivier Varenne, Fabien Picard
No abstract text is available yet for this article.
April 17, 2018: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/29672785/-tissue-engineering-of-adipose-tissue-with-biodegradable-biomaterials-for-soft-tissue-reconstruction
#15
Silvan Klein, Thiha Aung, Robert Michael Haas, Fabian Medved, Stefan M Schiller, Oliver Felthaus, Jürgen H Dolderer
Soft tissue defects resulting from injuries, tumor resection, congenital anomalies or chronic wounds pose a great challenge to reconstructive surgery. The current gold standard in therapy of such defects is the tissue transplantation in terms of free or local flaps. Unfortunately, donor site morbidity remains a considerable risk of flap surgery. Therefore, tissue engineering of autologous vascularized long term stable adipose tissue constructs could enrich the therapeutic possibilities of soft tissue defects...
April 2018: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/29668079/co-culture-of-adipose-derived-stem-cells-and-chondrocytes-on-three-dimensionally-printed-bioscaffolds-for-craniofacial-cartilage-engineering
#16
Robert J Morrison, Hassan B Nasser, Khaled N Kashlan, David A Zopf, Derek J Milner, Colleen L Flanangan, Matthew B Wheeler, Glenn E Green, Scott J Hollister
OBJECTIVES/HYPOTHESIS: Reconstruction of craniofacial cartilagenous defects are among the most challenging surgical procedures in facial plastic surgery. Bioengineered craniofacial cartilage holds immense potential to surpass current reconstructive options, but limitations to clinical translation exist. We endeavored to determine the viability of utilizing adipose-derived stem cell-chondrocyte co-culture and three-dimensional (3D) printing to produce 3D bioscaffolds for cartilage tissue engineering...
April 18, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29667581/relation-between-bioresorbable-scaffold-sizing-using-qca-dmax-and-long-term-clinical-outcomes-in-1-232-patients-from-3-study-cohorts-absorb-cohort-b-absorb-extend-and-absorb-ii
#17
Yuki Katagiri, Yoshinobu Onuma, Taku Asano, Ply Chichareon, Carlos Collet, Yosuke Miyazaki, Jan J Piek, Joanna J Wykrzykowska, Alexandre Abizaid, John A Ormiston, Bernard Chevalier, Patrick W Serruys
AIMS: This study sought to investigate the long-term clinical outcomes related to scaffold sizing based on quantitative coronary angiography. METHODS AND RESULTS: A total of 1,248 patients who received Absorb bioresorbable scaffolds in the ABSORB Cohort B, ABSOR EXTEND, ABSORB II trials were included in the analysis. The incidence of MACE (a composite of cardiac death, any myocardial infarction [MI], and ischemia-driven target lesion revascularization [ID-TLR]) was analysed according to the Dmax subclassification of oversized scaffold group versus non-oversized (any undersize) scaffold group...
April 17, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29661987/review-of-the-latest-percutaneous-devices-in-critical-limb-ischemia
#18
REVIEW
Leila Haghighat, Sophia Elissa Altin, Robert R Attaran, Carlos Mena-Hurtado, Christopher J Regan
Critical limb ischemia (CLI) is a terminal stage of peripheral arterial disease that, in the absence of intervention, may lead to lower extremity amputation or death. Endovascular interventions have become a first-line approach to the management of CLI and have advanced considerably within the past decade. This review summarizes the types of percutaneous devices and the techniques that are available for the management of CLI and the data supporting their use. These include devices that establish and maintain vessel patency, including percutaneous transluminal angioplasty, drug-coated balloons, bare metal stents, drug-eluting stents, bioresorbable vascular scaffolds, and atherectomy; devices that provide protection from embolization; and, cell-based therapies...
April 14, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29656280/real-world-bioresorbable-vascular-scaffold-experience-compared-with-second-generation-metallic-drug-eluting-stents-in-complex-coronary-lesions
#19
Naotaka Okamoto, Hiroshi Ueda, Takahiro Yoshimura, Surbhi Chamaria, Samit Bhatheja, Yuliya Vengrenyuk, Samaneh Rabiei, Yonandy Barrientos, Vishal Kapur, Nitin Barman, Joseph Sweeny, Usman Baber, Roxana Mehran, Samin K Sharma, Annapoorna S Kini
OBJECTIVES: The aim of the study was to compare the acute outcomes of Absorb bioresorbable vascular scaffolds (BVS) and second-generation drug-eluting stent (DES) implantation in routine clinical practice. There is a paucity of data regarding BVS use in a real-world patient population. METHODS: The study population comprised 40 consecutive patients who underwent percutaneous coronary intervention (PCI) with BVS implantation at a tertiary-care center in New York, New York between July and December of 2016...
April 15, 2018: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29649071/predictors-of-early-scaffold-thrombosis-results-from-the-multicenter-prospective-german-austrian-absorb-registry
#20
Jochen Wöhrle, Holger M Nef, Christoph Naber, Stephan Achenbach, Thomas Riemer, Julinda Mehilli, Thomas Münzel, Steffen Schneider, Sinisa Markovic, Julia Seeger, Wolfgang Rottbauer, Thomas Pfannebecker, Gert Richardt, Ralf Zahn, Tommaso Gori, Johannes Kastner, Axel Schmermund, Christian W Hamm
BACKGROUND: In randomized clinical trials, the risk of thrombotic events with the absorb bioresorbable vascular scaffold (BVS) was significantly higher than with metallic drug-eluting stents. We evaluated predictors of scaffold thrombosis in the large-scale, multicenter German-Austrian ABSORB RegIstRy. METHODS AND RESULTS: 3178 patients with treatment of 4252 lesions using 5020 scaffolds were included. Follow-up rate at 6 months was 97.4%. Forty-five (1.42%) patients experienced definite/probable scaffold thrombosis during follow-up...
April 11, 2018: Coronary Artery Disease
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