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Proteomics and vhc

Alaa Kamnaksh, Sook-Kyung Kwon, Erzsebet Kovesdi, Farid Ahmed, Erin S Barry, Neil E Grunberg, Joseph Long, Denes Agoston
Mild traumatic brain injury, caused by the exposure to single or repeated blast overpressure, is a principal concern due to its pathological complexity and neurobehavioral similarities with posttraumatic stress disorder. In this study, we exposed rats to a single or multiple (five total; administered on consecutive days) mild blasts, assessed their behavior at 1 and 16 days postinjury) and performed histological and protein analyses of brains and plasma at an early (2 h) and a late (22 days) termination time point...
December 2012: Electrophoresis
Erzsebet Kovesdi, Andrea B Gyorgy, Sook-Kyung C Kwon, Daniel L Wingo, Alaa Kamnaksh, Joseph B Long, Christine E Kasper, Denes V Agoston
De novo hippocampal neurogenesis contributes to functional recovery following traumatic brain injury (TBI). Enriched environment (EEN) can improve the outcome of TBI by positively affecting neurogenesis. Blast induced traumatic brain injury (bTBI) characterized by memory impairment and increased anxiety levels, is a leading cause of chronic disability among soldiers. Using a rodent model of bTBI we asked: (a) whether long-term exposure to EEN after injury can ameliorate behavioral abnormalities and (b) what the effects of EEN are at the molecular and cellular levels and on de novo neurogenesis...
2011: Frontiers in Neuroscience
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