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Corinna Lang-Schwarz, Balint Melcher, Franziska Haumaier, Klaus Lang-Schwarz, Thomas Rupprecht, Michael Vieth, William Sterlacci
Tumor budding is an independent prognostic factor in colorectal cancer (CRC) and has recently been well defined by the International Concensus Conference on Tumor Budding (ITBCC). Tumor infiltrating lymphocytes (TILs) are also an issue in different human cancers and correlate with prognosis in CRC. Here we evaluate the combination of budding and TILs in CRC with regard to prognosis. Hematoxylin and Eosin (H&E) stained slides of 501 CRC patients, diagnosed between 2005 and 2010 were reevaluated for tumor budding according to the ITBCC-criteria...
May 19, 2018: Human Pathology
Eva Karamitopoulou, Martin Wartenberg, Inti Zlobec, Silvia Cibin, Mathias Worni, Beat Gloor, Alessandro Lugli
AIMS: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with rising incidence. Biomarkers that would help the prognostic stratification of patients are needed urgently. Although tumour budding (BD) is a strong and independent prognostic factor in PDAC it is not included in histopathology reports, due partly to the lack of a standardised scoring system. The aim of the present work is to assess the reliability and reproducibility of the BD scoring system proposed recently by the International Tumour Budding Consensus Conference (ITBCC) 2016 in a well-characterised PDAC cohort (n = 120) with complete clinicopathological and follow-up information...
March 1, 2018: Histopathology
Wojciech Marlicz, Karolina Skonieczna-Zydecka, Igor Łoniewski
No abstract text is available yet for this article.
January 2018: American Journal of Gastroenterology
(no author information available yet)
No abstract text is available yet for this article.
July 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Jesper Holst Pedersen, Jens Benn Sørensen, Zaigham Saghir, Øystein Fløtten, Odd Terje Brustugun, Haseem Ashraf, Trond-Eirik Strand, Signe Friesland, Hirsh Koyi, Lars Ek, Sven Nyrén, Per Bergman, Antti Jekunen, Eeva-Maija Nieminen, Tomas Gudbjartsson
INTRODUCTION: We review the current knowledge of CT screening for lung cancer and present an expert-based, joint protocol for the proper implementation of screening in the Nordic countries. MATERIALS AND METHODS: Experts representing all the Nordic countries performed literature review and concensus for a joint protocol for lung cancer screening. RESULTS AND DISCUSSION: Areas of concern and caution are presented and discussed. We suggest to perform CT screening pilot studies in the Nordic countries in order to gain experience and develop specific and safe protocols for the implementation of such a program...
October 2017: Acta Oncologica
Gabriel Samasca, Aaron Lerner, Anamaria Girbovan, Genel Sur, Iulia Lupan, Peter Makovicky, Torsten Matthias, Hugh J Freeman
BACKGROUND: New treatments in coeliac disease are being vigorously pursued to either replace or facilitate the difficult-tofollow gluten-free diet. DESIGN: The present review intends to summarise the challenges in gluten-free diet adherence during the transitional period, as reflected in the last Prague consensus, published in 2016. RESULTS: The honourable panel members recommended that dietary adherence and the consequences of nonadherence represent key components for discussion in the transitional period setting...
May 2017: European Journal of Clinical Investigation
Gul Kanyilmaz, Meryem Aktan, Mehmet Koc, Hikmettin Demir, Lütfi Saltuk Demir
AIMS: To evaluate the incidental dose to the internal mammary chain (IMC) in patients treated with three-dimensional conformal radiotherapy, to estimate the predictors affecting the magnitude of IMC receiving dose and to determine the predictive role of clinical parameters on survival. MATERIALS AND METHODS: Between 2009 and 2015, 348 patients undergoing RT for breast cancer were retrospectively analyzed. All patients underwent our department's routine procedure for breast cancer...
June 2017: La Radiologia Medica
Rhian E Davies, Ian C Gilchrist
Patients with atrial fibrillation (AF) when stented with thin-strut colbalt chrome stents may have a similar outcome to patients without AF. Management of patients with AF potentially place patients at enhanced bleeding risk with triple antithrombotic therapy, or potential thrombotic risk if either oral anticoagulation is held or anti-platelet therapy is truncated. Guideline-based oral anticoagulation for AF is expanding this patient group presenting to the cardiac catheterization laboratory, yet management decisions are still based on limited studies and rely on expert concensus...
September 2016: Catheterization and Cardiovascular Interventions
Tamar Rubin, Jacqueline Clayton, Denise Adams, Rabin Persad, Sunita Vohra
BACKGROUND: Heterogeneity has been noted in the selection and reporting of disease-specific, pediatric outcomes in randomized controlled trials (RCTs). The consequence is invalid results or difficulty comparing results across trials. The primary objective of this systematic review was to assess primary outcome and outcome measure selection and reporting, in pediatric eosinophilic esophagitis (EoE) treatment trials. As secondary objectives, we compared trial disease definition to established concensus guidelines, and the efficacy of current EoE treatments...
2016: Allergy, Asthma, and Clinical Immunology
Norhayati Mohd Zain, Vengkatha Priya Seriramulu, Kanaga Kumari Chelliah
BACKGROUND: Bone mineral density (BMD) is a lifetime marker of estrogen in a woman's body and has been associated with increased breast cancer risk. Nonetheless the actual association is still debatable. Furthermore, estrogen is very crucial in maintaining human bone density and gradually decreases over age. A systematic search was conducted to assess any association of BMD with breast cancer risk factors among premenopausal and postmenopausal women. MATERIALS AND METHODS: Review identification was performed through databases searching on MEDLINE, CINAHL and SCOPUS and 19 qualified studies were elected...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
(no author information available yet)
No abstract text is available yet for this article.
May 25, 2016: Zhonghua Fu Chan Ke za Zhi
Ferhat Gürkan Aslan, Tercan Us, Nilgün Kaşifoğlu, Sabit Sinan Özalp, Yurdanur Akgün, Tufan Öge
Human papillomavirus (HPV) infections have a broad range of clinical spectrum from subclinical or asymptomatic infection to anogenital carcinoma. The detection of HPV-DNA and determination of the risk groups in cervical cancer (CC) screening is very important because CC is considered to be a preventable illness which is the third most common cancer type of women in the world. The aims of this study were to investigate the presence of HPV-DNA in women by two different molecular methods and to compare their results together with the results of cytology, in Eskişehir, Central Anatolia, Turkey...
January 2016: Mikrobiyoloji Bülteni
G A Desteli, N U Dogan, T Gursu, A Ayhan
Uterine clear cell carcinoma (UCC) is an aggressive variant of endometrial cancer. Comprehensive surgical staging is strongly recommended for these patients as an upstaging to Stage 3-4 occur in 35-50% of patients. Stage 1A (no myometrial invasion) according to FIGO 1988 staging system are seen very rarely in patients. In most of the studies, regarding adjuvant treatment, clear cell carcinoma were all evaluated with papillary serous carcinoma (PSC). Studies on clear cell histology are low in number and also a limited number of patients were included...
2016: European Journal of Gynaecological Oncology
Wei-cheng Deng, Zhen Yang, Hui-qun Xie, Yong-long Li, Jia-xin Liu, Guo-jian Ding, Yong-hui Zhu, Qun-shan Jing, Guo-qing Kong, Dan-dan Lin, Jian-bing Liu, Guang-hui Ren
In order to further standardize the diagnosis and treatment of schistosomiasis japonica in China, on the basis of evidence-based medicine, the experts on schistosomiasis control from Hunan, Hubei and Jiangxi provinces summarized their consensuses on the disease after the discussion on the current situation and progress of clinical diagnosis and treatment of schistosomiasis in China, with the reference to the Diagnostic Criteria for Schistosomiasis (WS261-2006), which aimed to establish the therapeutic standards or guideline of schistosomiasis in China...
October 2015: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
David M Moore, Connail McCrory
Chronic pain remains a challenging clinical problem with a growing socio-economic burden for the state. Its prevalence is high and many of the patients are of work age. Our knowledge regarding the pathophysiology of chronic pain is poor. The consensus view is that the central nervous system plays a key role in the persistence of pain after an initiating event has long ceased. However the specifics of this biological response to an initiating event remains unclear. There is a growing body of evidence to support the concept that a central neuroimmune response is initiated and a number of small peptides have been implicated in this process following cerebrospinal fluid analysis in patients with chronic pain...
2017: Current Neuropharmacology
G Kristiansen, L Egevad, M Amin, B Delahunt, J R Srigley, P A Humphrey, J I Epstein
In 2005 the International Society of Urological Pathology (ISUP) held a concensus conference on Gleason grading in order to bring this grading system up to the current state of contemporary practice; however, it became clear that further modifications on the grading of prostatic carcinoma were necessary. The International Society of Urological Pathology therefore held a further consensus conference in 2014 to clarify these points. This article presents the essential results of the Chicago grading meeting.
February 2016: Der Pathologe
Somanath Padhi, Kandasamy Ravichandran, Jayaprakash Sahoo, Renu G'Boy Varghese, Aneesh Basheer
BACKGROUND: Hemophagocytic lymphohistiocytosis (HLH) is an uncommon, potentially fatal, hyperinflammatory syndrome that may rarely complicate the clinical course of disseminated Mycobacterium tuberculosis (MTB). The clinical course of tuberculosis-associated HLH (TB-HLH) has been reported to be unpredictable. MATERIALS AND METHODS: Here we describe the clinicopathological features, laboratory parameters, management, and outcome data of a patient who satisfied the 2004 diagnostic criteria for HLH secondary to disseminated MTB; we also do a systematic review of the international literature on TB-HLH...
November 2015: Lung India: Official Organ of Indian Chest Society
Tetsuya Kai, Natsuki Ishibe, Yuji Soeda, Mariko Tanaka, Sumio Hoka
We successfully managed two fetuses complicated with suspected airway obstruction after birth by the EXIT (ex utero intrapartum treatment) procedure, whose placental circulation was maintained till their airway was secured during the cesarean section. The first fetus was suspected to have airway obstruction due to a large neck mass. At 36 weeks of gestation, the EXIT procedure was undertaken performing the tracheal intubation successfully by laryngoscope. The second fetus with micrognathia was expected to have airway obstruction after birth...
April 2015: Masui. the Japanese Journal of Anesthesiology
Björn Klinge, Thomas Flemming, Jan Cosyn, Hugo De Bruyn, Barbara M Eisner, Margareta Hultin, Flemming Isidor, Niklaus P Lang, Bodil Lund, Jürg Meyle, Andrea Mombelli, Jose Manuel Navarro, Bjarni Pjetursson, Stefan Renvert, Henning Schliephake
INTRODUCTION: The assignment for this working group was to update the existing knowledge regarding factors considered being of special relevance for the patient undergoing implant therapy. This included areas where conflicting opinions exists since long or recently has been expressed, like the role of antibiotic prophylaxis in dental implant surgery and peri-implantitis. Also areas with growing interest and concern such as patient-reported outcome measures (PROMs) and health-economy was included in this review...
September 2015: Clinical Oral Implants Research
Ebru H Biberoglu, Filiz Tanrıkulu, Mehmet Erdem, Ahmet Erdem, Kutay Omer Biberoglu
Vaginal progesterone (P) has been suggested to be used for luteal phase support (LPS) in controlled ovarian stimulation (COH)-intrauterine insemination (IUI) cycles, however, no concensus exists about the best P dose. Therefore, considering the fecundability rate as the primary end point, our main objective was to find the optimal dose of P in COH-IUI cycles, comparing the two groups of women, each of which comprised of 100 women either on 300 mg or 600 mg of intravaginal P tablets, in a prospective randomized study design...
2016: Gynecological Endocrinology
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