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Linezolid and vancomycin

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https://www.readbyqxmd.com/read/27898030/assessment-of-the-activity-of-tigecycline-against-gram-positive-and-gram-negative-organisms-collected-from-italy-between-2012-and-2014-as-part-of-the-tigecycline-evaluation-and-surveillance-trial-t-e-s-t
#1
Stefania Stefani, Michael J Dowzicky
As part of the Tigecycline Evaluation and Surveillance Trial (T.E.S.T) we report the in vitro activity of tigecycline and its comparators against Gram-negative and Gram-positive organisms collected from Italian centers between 2012 and 2014. Minimum inhibitory concentrations were determined according to the broth microdilution methodology of the Clinical and Laboratory Standards Institute, and antimicrobial resistance was determined using the European Committee on Antimicrobial Susceptibility Testing interpretive criteria...
November 26, 2016: Pharmaceuticals
https://www.readbyqxmd.com/read/27895134/vancomycin-and-the-risk-of-aki-a-systematic-review-and-meta-analysis
#2
Abhisekh Sinha Ray, Ammar Haikal, Kassem A Hammoud, Alan S L Yu
BACKGROUND AND OBJECTIVES: Vancomycin has been in use for more than half a century, but whether it is truly nephrotoxic and to what extent are still highly controversial. The objective of this study was to determine the risk of AKI attributable to intravenous vancomycin. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a systematic review of randomized, controlled trials and cohort studies that compared patients treated with intravenous vancomycin with a control group of patients given a comparator nonglycopeptide antibiotic and in which kidney function or kidney injury outcomes were reported...
November 28, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27891339/bacteriological-profile-of-isolates-from-urine-samples-in-patients-of-benign-prostatic-hyperplasia-and-or-prostatitis-showing-lower-urinary-tract-symptoms
#3
Prem Prakash Mishra, Ved Prakash, Kashmir Singh, H Mog, Sumit Agarwal
INTRODUCTION: The incidence of Benign Prostatic Hyperplasia (BPH) or Prostatitis is increasing considerably worldwide. The Lower Urinary Tract Symptoms (LUTS) due to bacterial aetiology are one of the common factors for the complications among the patients. AIM: To determine the bacterial agents and their antibiotic sensitivity pattern from the urine samples of patients of BPH or Prostatitis showing symptoms of LUTS. MATERIALS AND METHODS: The cross-sectional study was carried out in the Department of Microbiology of Rohilkhand Medical College and Hospital of Northern India from June 2014 to May 2015...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27890418/comparative-in-vitro-activity-of-oritavancin-and-other-agents-against-methicillin-susceptible-and-methicillin-resistant-staphylococcus-aureus
#4
Debora Sweeney, Dean L Shinabarger, Francis F Arhin, Adam Belley, Greg Moeck, Chris M Pillar
Methicillin-resistant Staphylococcus aureus (MRSA) infections constitute a threat to the public health due to their prevalence and associated mortality and morbidity. Several agents have been recently approved to treat MRSA skin infections including lipoglycopeptides (dalbavancin, oritavancin, and telavancin), ceftaroline, and tedizolid. This study compared the MIC, minimum bactericidal concentration (MBC), and time-kill of these agents alongside daptomycin, linezolid, and vancomycin against MRSA (n=15); meropenem, cefazolin, and nafcillin were also included against methicillin-susceptible S...
November 12, 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27889013/methicillin-resistant-staphylococcus-aureus-infections-a-review-of-the-currently-available-treatment-options
#5
REVIEW
S M Purrello, J Garau, E Giamarellos, T Mazzei, F Pea, A Soriano, S Stefani
This review is the result of discussions that took place at the 5th MRSA Working Group Consensus Meeting and explores the possible treatment options available for different types of infections due to methicillin-resistant Staphylococcus aureus (MRSA), focusing on those antibiotics that could represent a valid alternative to vancomycin. In fact, whilst vancomycin remains a viable option, its therapy is moving towards individualised dosing. Other drugs, such as the new lipoglycopeptides (oritavancin, dalbavancin and telavancin) and fifth-generation cephalosporins (ceftaroline and ceftobiprole), are showing good in vitro potency and in vivo efficacy, especially for patients infected with micro-organisms with higher vancomycin minimum inhibitory concentrations (MICs)...
December 2016: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/27873126/resistance-to-non-glycopeptide-agents-in-serious-staphylococcus-aureus-infections
#6
REVIEW
Kyle C Molina, Vanthida Huang
The role of vancomycin in the treatment of serious Staphylococcus aureus infections, both methicillin-susceptible and methicillin-resistant, is becoming increasingly ineffective due to increasing MIC and failure. The development of reduced vancomycin susceptibility by S. aureus to glycopeptides highlights the need for clinicians to reexamine the roles of non-glycopeptide therapy. As the use of these alternative non-glycopeptides antimicrobials increases, it will become pertinent to monitor the rates of resistance...
December 2016: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/27867829/intrathecal-intraventricular-linezolid-in-multidrug-resistant-enterococcus-faecalis-ventriculitis
#7
Brian F Lich, Andrew K Conner, Joshua D Burks, Chad A Glenn, Michael E Sughrue
Background The use of intrathecal antibiotic therapy for the treatment of ventriculitis and/or meningitis has demonstrated efficacy especially when sterilization of the cerebrospinal fluid is not possible with intravenous antibiotics alone. Case Description We describe the successful treatment of Enterococcus faecalis ventriculitis utilizing intrathecal linezolid in a 32-year-old female patient with severe allergy to vancomycin, prohibitive bacterial susceptibilities, and failure of previous attempts to sterilize the cerebrospinal fluid despite multimodal treatment...
October 2016: Journal of Neurological Surgery Reports
https://www.readbyqxmd.com/read/27866673/surveillance-of-tedizolid-activity-and-resistance-in-vitro-susceptibility-of-gram-positive-pathogens-collected-over-5-years-from-the-united-states-and-europe
#8
Mekki Bensaci, Daniel Sahm
In vitro activity of tedizolid and comparators against 11,231 Gram-positive clinical isolates from the United States (84 centers) and Europe (115 centers) were summarized as part of the Surveillance of Tedizolid Activity and Resistance program between 2009 and 2013. Susceptibility testing was performed according to Clinical Laboratory and Standards Institute (CLSI) guidelines. Minimum inhibitory concentration (MIC) interpretations were based on CLSI and European Committee on Antimicrobial Susceptibility Testing criteria...
October 8, 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27856079/in-vitro-activity-of-ceftobiprole-on-440-staphylococcus-aureus-strains-isolated-from-bronchopulmonary-infections
#9
E Hodille, L Delouere, C Bouveyron, H Meugnier, M Bes, A Tristan, F Laurent, F Vandenesch, G Lina, O Dumitrescu
OBJECTIVE: We assessed the in vitro activity of ceftobiprole on 440 Staphylococcus aureus clinical strains isolated from bronchopulmonary infections (2010-2014). METHODS: S. aureus isolates were characterized for methicillin resistance, PVL status, and clonal complex. All isolates were tested for minimal inhibitory concentrations (MIC) determination by broth microdilution method for ceftobiprole, ceftaroline fosamil, and comparator antibiotics (linezolid, tigecycline, vancomycin, and daptomycin)...
November 14, 2016: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/27855057/-sensitivity-and-antibiotic-resistance-in-infections-of-the-musculoskeletal-system
#10
Argenis Mata-Hernández, Adrián Huematzin Rivera-Villa, Adrián Miguel-Pérez, José Manuel Pérez-Atanasio, Rubén Torres-González
BACKGROUND: Infections of the musculoskeletal system are a devastating complication for patients, due to it's long rehabilitation process and even sometimes the removal of the implant, the chronicity of infection, is often due to lack of coverage in empirical antibiotics. METHODS: A retrospective, observational, descriptive cohort study was performed. All cultures form musculoskeletal system infected patients reported of sensitivity and resistance of germs isolated were analyzed...
2016: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/27852379/-investigation-of-molecular-epidemiology-of-methicillin-resistant-staphylococcus-aureus-in-department-of-critical-care-medicine
#11
Y X Qin, Q D Li, X Y Wan, L Y Bi, J Wang
Objective: To investigate the feature of antimicrobial resistance, homology and other molecular epidemiology of methicillin-resistant staphylococcus aureus(MRSA) in Department of Critical Care Medicine(ICU). Methods: From October 2010 to December 2011, 149 strains of MRSA were collected and identified through sputum culture of patients from 10 ICUs of 10 teaching hospitals distributed in 9 chinese central city of China. Susceptibility testing to 18 kinds of antibiotic was performed, the method of pulsed field gel electrophoresis (PFGE) was used to analyze the homology, and the technique of multilocus sequencing typing (MLST) was used to identify the sequence type (ST)...
November 8, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27850343/705-linezolid-vs-vancomycin-for-treatment-of-nosocomial-pneumonia-due-to-methicillin-resistant-s-aureus
#12
Hiroaki Takada, Toru Hifumi, Yuichi Koido, Yasuhiro Kuroda, Hiroshi Kato
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27850313/674-length-of-stay-in-patients-with-influenza-and-bacterial-pneumonia-receiving-vancomycin-or-linezolid
#13
Carly Stoneman, Shauna Winters, Lauren Labeff, Eric Heidel, Leslie Hamilton
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27850309/670-implementation-of-mrsa-pcr-testing-to-decrease-vancomycin-and-linezolid-utilization
#14
Jeffery Spray, Brittina Powers, Larissa Coyle, Marcia Brackbill
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27835845/pronounced-heterogeneity-observed-in-high-level-daptomycin-resistant-viridans-group-streptococci
#15
Ronda L Akins, Katie E Barber, Kelli L Palmer
Viridans group streptococci (VGS) have demonstrated high-level daptomycin resistance (HLDR) upon daptomycin exposure. This study evaluated the extent of heterogeneity and whether dose escalation or combination therapy could prevent resistance development. Five VGS strains (daptomycin MICs 0.25-2mg/L) were evaluated. In vitro models utilised simulated daptomycin dosages of 4, 6, 8 and 12mg/kg with estimated fCmax of 4.1, 6.6, 8.6 and 12.9mg/L, respectively. Time-kill studies included fCmax simulations of daptomycin alone or combined with ceftriaxone, gentamicin, linezolid, rifampicin or vancomycin...
December 2016: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/27832976/linezolid-versus-vancomycin-for-nosocomial-pneumonia-due-to-methicillin-resistant-staphylococcus-aureus-in-the-elderly-a-retrospective-cohort-analysis-effectiveness-of-linezolid-in-the-elderly
#16
Hiroaki Takada, Toru Hifumi, Naoki Nishimoto, Takashi Kanemura, Hayato Yoshioka, Ichiro Okada, Nobuaki Kiriu, Junichi Inoue, Yuichi Koido, Hiroshi Kato
OBJECTIVES: Several reports have compared the efficacy of linezolid (LZD) in Methicillin-resistant Staphylococcus aureus (MRSA) infections with that of vancomycin (VCM); however, these two antibiotics for the treatment of nosocomial MRSA pneumonia in elderly patients has not been well evaluated. The purpose of this study is to evaluate the efficacy and safety of LZD compared with VCM for the treatment of elderly patients with nosocomial MRSA pneumonia in a retrospective chart review of a cohort...
October 29, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27825734/predominance-of-sccmec-types-iv-and-v-among-biofilm-producing-device-associated-staphylococcus-aureus-strains-isolated-from-tertiary-care-hospitals-in-mysuru-india
#17
Pradeep Halebeedu Prakash, Vineeth Rajan, Shubha Gopal
INTRODUCTION: Device associated infections caused by Staphylococcus aureus in hospitalised patients is a serious healthcare problem. The present study was designed to determine the prevalence of biofilm-producing MRSA in device-associated infections. METHODS: Device-associated S. aureus strains (n=200) obtained from two tertiary care hospitals in Mysuru city, India were screened for biofilm production, antibiotic resistance, Panton-Valentine Leucocidin genes, SCCmec-types, spa-types, and intercellular adhesion (icaAD) dependent and independent genes...
November 5, 2016: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/27818775/characterization-and-antimicrobial-susceptibility-of-one-antibiotic-sensitive-and-one-multidrug-resistant-corynebacterium-kroppenstedtii-strain-isolated-from-patients-with-granulomatous-mastitis
#18
I Fernández-Natal, D Rodríguez-Lázaro, T Marrodán-Ciordia, J A Sáez-Nieto, S Valdezate, H Rodríguez-Pollán, A Tauch, F Soriano
Human infections associated with Corynebacterium kroppenstedtii are rarely reported, and this organism is usually described as antibiotic sensitive. Almost all published cases of C. kroppenstedtii infections have been associated with breast pathology in women and have been described in New Zealand, France, Canada, India and Japan. Here we describe the microbiologic characteristics of two strains isolated from two women diagnosed of granulomatous mastitis in Spain. One C. kroppenstedtii isolate was antibiotic sensitive while the other was multidrug resistant...
November 2016: New Microbes and New Infections
https://www.readbyqxmd.com/read/27803456/linezolid-induced-thrombocytopenia-is-caused-by-suppression-of-platelet-production-via-phosphorylation-of-myosin-light-chain-2
#19
Masataka Tajima, Yoshinori Kato, Jun Matsumoto, Iori Hirosawa, Mariko Suzuki, Yuki Takashio, Mao Yamamoto, Yoshifumi Nishi, Harumi Yamada
Linezolid (LZD) is an antimicrobial that is commonly used for treatment of vancomycin-resistant Enterococci and methicillin-resistant Staphylococcus aureus infections. However, the development of thrombocytopenia, one of the most frequent adverse side effects of this antimicrobial, can lead to discontinuation of LZD treatment. While clinical studies indicate that risk factors for the development of LZD-induced thrombocytopenia include treatment for >14 consecutive days, renal dysfunction, and chronic liver disease, the fundamental mechanism governing the pathogenesis of this disorder remains unclear...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27793509/toxin-profiles-pcr-ribotypes-and-resistance-patterns-of-clostridium-difficile-a-multicentre-study-in-china-2012-2013
#20
Qiong Gao, Shi Wu, Haihui Huang, Yuxing Ni, Ye Chen, Yunjian Hu, Yunsong Yu
A total of 178 clinical isolates of Clostridium difficile were collected from five major teaching hospitals representing northern, eastern and southern China from August 2012 to July 2013. Among the 178 isolates, 162 (91.0%) were toxigenic, including 66 (40.7%) toxin A-negative, toxin B-positive, 95 (58.6%) toxin A-positive, toxin B-positive and only 1 (0.6%) toxin A-, toxin B- and binary toxin-positive. Twenty-nine different PCR ribotypes were identified, of which 017 (21.0%), 012 (17.3%) and novel type H (16...
October 17, 2016: International Journal of Antimicrobial Agents
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