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https://www.readbyqxmd.com/read/28342937/molecular-epidemiology-of-staphylococcus-aureus-nasal-colonization-among-patients-and-their-parents-guardian-in-an-iranian-referral-hospital
#1
Babak Pourakbari, Mahmoud Khodabandeh, Shima Mahmoudi, Farah Sabouni, Alireza Aziz-Ahari, Abbas Bahador, Sepideh Keshavarz Valian, Reihaneh Hosseinpour Sadeghi, Setareh Mamishi
INTRODUCTION: Carriage of Staphylococcus aureus in the nose appears to play a key role in the epidemiology and pathogenesis of infection. It is important to investigate the genetic relatedness of S. aureus and MRSA clones in different geographic regions. The aim of this study was to assess the nasal carriage rate of S. aureus, including MRSA strains in both hospitalized children and general adult population (parents/guardian). In addition, antibiotic susceptibility pattern and molecular diversity of S...
March 22, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28333257/comparative-effectiveness-of-linezolid-versus-vancomycin-as-definitive-antibiotic-therapy-for-heterogeneously-resistant-vancomycin-intermediate-coagulase-negative-staphylococcal-central-line-associated-bloodstream-infections-in-a-neonatal-intensive-care-unit
#2
A C Blanchard, E Fortin, C Laferrière, I Goyer, A Moussa, J Autmizguine, C Quach
Objectives: Heterogeneously resistant vancomycin-intermediate coagulase-negative staphylococci (hVICoNS) are emerging pathogens causing central-line-associated bloodstream infections (CLABSIs) in neonatal intensive care unit (NICU) patients. Given the burden of disease associated with CLABSI and the current lack of therapeutic guidelines, we aimed to compare the effectiveness of linezolid versus vancomycin used as the definitive antibiotic therapy for hVICoNS CLABSI. Methods: We performed a retrospective cohort study of infants with hVICoNS CLABSI from a single NICU between 2009 and 2014, treated with either linezolid or vancomycin as definitive antibiotic therapy...
March 3, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28332345/high-incidence-of-virulence-factors-among-clinical-enterococcus-faecalis-isolates-in-southwestern-iran
#3
Hamid Heidari, Somayeh Hasanpour, Hadi Sedigh Ebrahim-Saraie, Mohammad Motamedifar
BACKGROUND: Over the past two decades, enterococci have emerged as an important agent responsible for hospital acquired infection. Several virulence factors contribute to the adherence, colonization, evasion of the host immune response, and pathogenicity and severity of the infection. Enterococcus faecalis is the most common and virulent species causing infections in hospitalized patients. The aim of the present study was to examine the prevalence of genes encoding virulence factors and antimicrobial resistance patterns of E...
March 13, 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28330484/antibiotic-resistance-and-biofilm-production-among-the-strains-of-staphylococcus-aureus-isolated-from-pus-wound-swab-samples-in-a-tertiary-care-hospital-in-nepal
#4
Ankit Belbase, Narayan Dutt Pant, Krishus Nepal, Bibhusan Neupane, Rikesh Baidhya, Reena Baidya, Binod Lekhak
BACKGROUND: The increasing drug resistance along with inducible clindamycin resistance, methicillin resistance and biofilm production among the strains of Staphylococcus aureus are present as the serious problems to the successful treatment of the infections caused by S. aureus. So, the main objectives of this study were to determine the antimicrobial susceptibility patterns along with the rates of inducible clindamycin resistance, methicillin resistance and biofilm production among the strains of S...
March 23, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28326447/in-vitro-activity-of-tedizolid-and-linezolid-against-staphylococcus-epidermidis-isolated-from-prosthetic-joint-infections
#5
C Littorin, B Hellmark, Å Nilsdotter-Augustinsson, B Söderquist
Prosthetic joint infections (PJIs) are rare but long-lasting and are serious complications without any spontaneous resolution, requiring additional surgery and long-term treatment with antibiotics. Staphylococci are the most important aetiological agents of PJIs, and among the coagulase-negative staphylococci Staphylococcus epidermidis is the most common. However, S. epidermidis often displays multidrug resistance (MDR), demanding additional treatment options. The objective was to examine the effectiveness of tedizolid and linezolid against S...
March 22, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28321212/microbiological-characteristics-and-clinical-features-of-cardiac-implantable-electronic-device-infections-at-a-tertiary-hospital-in-china
#6
Ruobing Wang, Xuebin Li, Qi Wang, Yawei Zhang, Hui Wang
The incidence of cardiac implantable electronic device (CIED) infections is rapidly increasing worldwide. However, the microbiological characteristics and clinical features of symptomatic CIED infections are not well described. The present study included patients with CIED infections in China, and their pocket tissues were collected for clinical microbiological determination. A total of 219 patients with CIED infections were investigated; of these patients, 145 (66.2%) were positive for CIED infection in pocket tissue cultures and 24 (11...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28303819/prevalence-and-genetic-mechanisms-of-antimicrobial-resistance-in-staphylococcus-species-a-multicentre-report-of-the-indian-council-of-medical-research-antimicrobial-resistance-surveillance-network
#7
Sunanda Rajkumar, Sujatha Sistla, Meerabai Manoharan, Madhan Sugumar, Niveditha Nagasundaram, Subhash Chandra Parija, Pallab Ray, Yamuna Devi Bakthavatchalam, Balaji Veeraraghavan, Arti Kapil, Kamini Walia, V C Ohri
PURPOSE: Routine surveillance of antimicrobial resistance (AMR) is an essential component of measures aimed to tackle the growing threat of resistant microbes in public health. This study presents a 1-year multicentre report on AMR in Staphylococcus species as part of Indian Council of Medical Research-AMR surveillance network. MATERIALS AND METHODS: Staphylococcus species was routinely collected in the nodal and regional centres of the network and antimicrobial susceptibility testing was performed against a panel of antimicrobials...
January 2017: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28293153/susceptibility-profile-of-methicillin-resistant-staphylococcus-aureus-to-linezolid-in-clinical-isolates
#8
Ali Shariq, Syed Bilal Tanvir, Atif Zaman, Salman Khan, Armeena Anis, Misha Aftab Khan, Sumaira Ahmed
OBJECTIVE: To determine the resistance and sensitivity pattern of methicillin-resistant Staphylococcus aureus (MRSA) isolates to linezolid (LZD) along with its prevalence in a tertiary care hospital of Karachi, Pakistan. MATERIALS AND METHODS: A cross-sectional study was carried out. This study lasted for about 1 year. Prevalence and sensitivity of LZD, vancomycin, and oxacillin was tested against isolates of MRSA. RESULTS: Out of total 369 specimens 165 were found to be MRSA making the prevalence in our study 44...
January 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/28273381/role-of-combination-antimicrobial-therapy-for-vancomycin-resistant-enterococcus-faecium-infections-review-of-the-current-evidence
#9
Juwon Yim, Jordan R Smith, Michael J Rybak
Enterococcus species are the second most common cause of nosocomial infections in the United States and are particularly concerning in critically ill patients with preexisting comorbid conditions. Rising resistance to antimicrobials that were historically used as front-line agents for treatment of enterococcal infections, such as ampicillin, vancomycin, and aminoglycosides, further complicates the treatment of these infections. Of particular concern are Enterococcus faecium strains that are associated with the highest rate of vancomycin resistance...
March 8, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28267763/molecular-characterization-of-vancomycin-resistant-enterococcus-faecium-isolates-from-bermuda
#10
Patrick Eberechi Akpaka, Shivnarine Kissoon, Clyde Wilson, Padman Jayaratne, Ashley Smith, George R Golding
Molecular characteristics of vancomycin resistant enterococci isolates from Bermuda Island is currently unknown. This study was conducted to investigate phenotypic and genotypic characteristics of VRE isolates from Bermuda Island using the chromogenic agar, E-tests, polymerase chain reaction (PCR), pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST). Eighteen E. faecium isolates were completely analyzed and were all resistant to vancomycin, susceptible to linezolid and quinupristin/dalfopristin, positive for vanA and esp genes...
2017: PloS One
https://www.readbyqxmd.com/read/28264856/effect-of-continuous-and-sequential-therapy-among-veterans-receiving-daptomycin-or-linezolid-for-vancomycin-resistant-enterococcus-faecium-bacteremia
#11
Nicholas S Britt, Emily M Potter, Nimish Patel, Molly E Steed
Vancomycin-resistant Enterococcus faecium bloodstream infections (VREF-BSI) cause significant mortality, highlighting the need to optimize treatment. We compared the effectiveness and safety of daptomycin (DAP) and linezolid (LZD) as continuous or sequential therapy for VREF-BSI in a national, retrospective, propensity score (PS) matched cohort study of hospitalized Veterans Affairs patients (2004-2014). We compared clinical outcomes and adverse events among patients treated with continuous LZD, continuous DAP, or sequential LZD followed by DAP (LZD-DAP)...
March 6, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28264610/corynebacterium-species-causing-breast-abscesses-among-patients-attending-a-tertiary-care-hospital-in-chennai-south-india
#12
Indira Poojary, Ann Kurian, Jayalekshmi V A, Debora Devapriya J, Thirunarayan M A
BACKGROUND: Corynebacterium species other than Corynebacterium diphtheriae were mostly considered contaminants in the past, but there are reports of their association with wide variety of human infections lately. In this study, we look into Corynebacterium species isolated from breast abscess patients and assess their antimicrobial susceptibility pattern and treatment outcomes. MATERIAL AND METHODS: Pus samples from suspected breast abscess cases were examined from October 2014 to September 2015...
March 6, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28259072/a-rare-case-of-acute-osteomyelitis-due-to-panton-valentine-leukocidin-positive-community-acquired-methicillin-resistant-staphylococcus-aureus-in-a-young-healthy-adult
#13
Toshiyuki Takemori, Osamu Nakamura, Yoshiki Yamagami, Hideki Nishimura, Teruya Kawamoto, Toshihiro Akisue, Tetsuji Yamamoto
INTRODUCTION: Most community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections affect skin or soft tissues, while invasive and life-threatening illnesses including osteomyelitis are less common. CA-MRSA infections occur especially in the pediatric age group, while the occurrence of CA-MRSA osteomyelitis in adults is uncommonly reported. PRESENTATION OF CASES: A rare case of acute osteomyelitis of the femur caused by Panton-Valentine leukocidin (PVL)-positive CA-MRSA in a 37-year-old man in good health is presented...
February 17, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28257904/in-vitro-activity-of-ceftaroline-and-comparator-agents-against-gram-positive-and-gram-negative-clinical-isolates-from-cancer-patients
#14
Kenneth V I Rolston, Mohamed A Jamal, Lior Nesher, Samuel A Shelburne, Issam Raad, Randall A Prince
Bacterial infections are common in cancer patients. Ceftaroline (CFT) is a broad-spectrum cephalosporin with activity against most Gram-positive organisms (GPOs) and many Gram-negative organisms. In this study, the in vitro activity of CFT was compared with vancomycin (VAN), daptomycin (DAP), linezolid (LZD), trimethoprim/sulphamethoxazole (SXT) and tigecycline (TIG) against bacteria (predominantly blood culture isolates) isolated from cancer patients in 2014 and 2015. CFT was active against methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant S...
February 28, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28257884/development-of-advanced-biantibiotic-loaded-bone-cement-spacers-for-arthroplasty-associated-infections
#15
F J Parra-Ruíz, A González-Gómez, M Fernández-Gutiérrez, J Parra, J García-García, G Azuara, B De la Torre, J Buján, B Ibarra, L Duocastella-Codina, M Molina-Crisol, B Vázquez-Lasa, J San Román
The incidence increase of infections in patients with hip or knee implants with resistant pathogens (mainly some S. coagulase-negative and gram positive bacteria) demands advanced antibiotic loaded formulations. In this paper, we report the design of new biantibiotic acrylic bone cements for in situ delivery. They include a last generation antibiotic (daptomycin or linezolid) in combination with vancomycin and are performed based on a novel modification of the Palacos R(®) acrylic bone cement, which is based on two components, a liquid (methyl methacrylate) and a solid (polymeric phase)...
February 28, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28249208/diphenylurea-derivatives-for-combating-methicillin-and-vancomycin-resistant-staphylococcus-aureus
#16
Ibrahim H Eissa, Haroon Mohammad, Omar A Qassem, Waleed Younis, Tamer M Abdelghany, Ahmed Elshafeey, Mahmoud M Abd Rabo Moustafa, Mohamed N Seleem, Abdelrahman S Mayhoub
A new class of diphenylurea was identified as a novel antibacterial scaffold with an antibacterial spectrum that includes highly resistant staphylococcal isolates, namely methicillin- and vancomycin-resistant Staphylococcus aureus (MRSA & VRSA). Starting with a lead compound 3 that carries an aminoguanidine functionality from one side and a n-butyl moiety on the other ring, several analogues were prepared. Considering the pharmacokinetic parameters as a key factor in structural optimization, the structure-activity-relationships (SARs) at the lipophilic side chain were rigorously examined leading to the discovery of the cycloheptyloxyl analogue 21n as a potential drug-candidate...
April 21, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28247627/-five-year-analysis-of-microbial-landscape-of-transplantation-and-dialysis-center-20112015
#17
A B Zulkarnaev, A V Vatazin, E V Rusanova, V A Fedulkina, S A Pasov
INTRODUCTION: Treatment of bacterial infections is pressing and difficult task of modern transplantology. AIM: To analyze the spectrum of bacterial microflora and bacterial sensitivity to antibiotics in patients of the transplantation and dialysis center. RESULTS: The study analyzed the results of bacteriological tests performed in 534 patients with chronic kidney disease stage 5 in 2011-2015. Biomaterials for the examination included urine, blood, wound discharge and sputum...
August 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28236797/community-acquired-pneumonia-caused-by-methicillin-resistant-staphylococcus-aureus-in-critically-ill-patients-systematic-review
#18
Nuria Carballo, Marta De Antonio-Cuscó, Daniel Echeverría-Esnal, Sonia Luque, Esther Salas, Santiago Grau
INTRODUCTION: Community-acquired pneumonia (CAP) is associated with high morbidity and mortality rates. Despite methicillin-resistant Staphylococcus aureus (MRSA) having often been associated with nosocomial pneumonia, the condition of some MRSA CAP patients is severe enough to warrant their being admitted to ICU. OBJECTIVE: The purpose of this study is to conduct a systematic review of the literature on antibiotic treatment of MRSA CAP in critically-ill patients...
March 1, 2017: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/28235571/efficacy-of-rifampicin-combination-therapy-for-the-treatment-of-enterococcal-infections-assessed-in-vivo-using-a-galleria-mellonella-infection-model
#19
Kirsty Skinner, Jonathan A T Sandoe, Ranjith Rajendran, Gordon Ramage, Sue Lang
Enterococci are a leading cause of healthcare-associated infection worldwide and display increasing levels of resistance to many of the commonly used antimicrobials, making treatment of their infections challenging. Combinations of antibiotics are occasionally employed to treat serious infections, allowing for the possibility of synergistic killing. The aim of this study was to evaluate the effects of different antibacterial combinations against enterococcal isolates using an in vitro approach and an in vivo Galleria mellonella infection model...
February 21, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28225903/sphygmomanometers-and-thermometers-as-potential-fomites-of-staphylococcus-haemolyticus-biofilm-formation-in-the-presence-of-antibiotics
#20
Bruna Pinto Ribeiro Sued, Paula Marcele Afonso Pereira, Yuri Vieira Faria, Juliana Nunes Ramos, Vanessa Batista Binatti, Kátia Regina Netto Dos Santos, Sérgio Henrique Seabra, Raphael Hirata, Verônica Viana Vieira, Ana Luíza Mattos-Guaraldi, José Augusto Adler Pereira
BACKGROUND: The association between Staphylococcus haemolyticus and severe nosocomial infections is increasing. However, the extent to which fomites contribute to the dissemination of this pathogen through patients and hospital wards remains unknown. OBJECTIVES: In the present study, sphygmomanometers and thermometers were evaluated as potential fomites of oxacillin-resistant S. haemolyticus (ORSH). The influence of oxacillin and vancomycin on biofilm formation by ORSH strains isolated from fomites was also investigated...
March 2017: Memórias do Instituto Oswaldo Cruz
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