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https://www.readbyqxmd.com/read/29229402/full-field-strain-distribution-in-multi-vertebra-spine-segments-an-in-vitro-application-of-digital-image-correlation
#1
Marco Palanca, Miguel Marco, Maria Luisa Ruspi, Luca Cristofolini
The biomechanics of the spine is experimentally assessed in terms of range of motion and overall stiffness. Quantification of the surface strain distribution is currently limited either to the vertebrae or the discs, whereas a full-field approach to measure the strain distribution in a multi-vertebra segment is currently missing. The aim of this work was to explore the feasibility of using Digital Image Correlation (DIC) to measure the strain distribution simultaneously on the vertebral bodies and the intervertebral discs of spine segments in different loading configurations...
December 8, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/29202297/finite-element-investigation-of-the-effect-of-nucleus-removal-on-vibration-characteristics-of-the-lumbar-spine-under-a-compressive-follower-preload
#2
Wei Fan, Li-Xin Guo
Previous studies have reported the effect of removing the nucleus on biomechanical responses of the human spine to static loadings. However, few studies have dealt with the whole-body vibration condition. The purpose of this study was to investigate the effect of a single-level (L4-L5) nucleus removal on vibration characteristics of the whole lumbar spine in the presence of a physiologic compressive preload, and also to evaluate the preload effect on the vibration characteristics. A 3-D non-linear finite element model of the lumbar spine (L1 to sacrum) subjected to the physiologic conditions of a compressive follower preload was developed and validated...
November 26, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29154999/kinematic-analysis-of-the-space-available-for-cord-and-disc-bulging-of-the-thoracic-spine-using-kinematic-magnetic-resonance-imaging-kmri
#3
Permsak Paholpak, Ishan Shah, Lou-Anne Acevedo-Moreno, Koji Tamai, Jeffrey C Wang, Zorica Buser
BACKGROUND CONTEXT: The thoracic spine was previously known as a relatively stable region in human spine. Several studies reported motion of the thoracic spine and changes in the cross-sectional area of the spinal cord changed with positions in sagittal plane. The kinematic relationship between the thoracic disc and space available for cord with the positional change is still not well investigated. PURPOSE: To evaluate the kinematic change of the intervertebral disc and space available for the spinal cord of the thoracic spine using kMRI...
November 14, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29147797/is-it-appropriate-to-measure-age-related-lumbar-disc-degeneration-on-the-mid-sagittal-mr-image-a-quantitative-image-study
#4
Xiaojian Hu, Mingjian Chen, Jianjiang Pan, Liang Liang, Yue Wang
PURPOSE: Even though phenotypes of disc degeneration vary on different sagittal magnetic resonance images (MRI), measurements typically are acquired on the mid-sagittal MRI. This study investigated the appropriateness of using the mid-sagittal MRI to measure various phenotypes of age-related disc degeneration. METHODS: Lumbar spine MRIs of 66 subjects (mean age 50.3 years, standard deviation 16.5 years, range 22-84 years) were studied. An image analysis program Spine Explorer was used to obtain quantitative measurements for disc height, bulging, and signal on para- and mid-sagittal T2-weighted MRIs...
November 17, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29141001/the-associations-between-magnetic-resonance-imaging-findings-and-low-back-pain-a-10-year-longitudinal-analysis
#5
Juichi Tonosu, Hiroyuki Oka, Akiro Higashikawa, Hiroshi Okazaki, Sakae Tanaka, Ko Matsudaira
PURPOSE: To conduct a 10-year longitudinal analysis of the relationship between magnetic resonance imaging (MRI) findings and low back pain (LBP). MATERIALS AND METHODS: Ninety-one volunteers with a history of LBP, but without current LBP were recruited between 2005 and 2006. Participants' baseline demographics and MRI findings were recorded. All volunteers were invited for a follow-up MRI in 2016; of these, 49 volunteers (53.8%) participated in the follow-up. We enquired whether they had LBP history during the 10 years between the baseline and follow-up examinations...
2017: PloS One
https://www.readbyqxmd.com/read/29038477/long-non-coding-hcg18-promotes-intervertebral-disc-degeneration-by-sponging-mir-146a-5p-and-regulating-traf6-expression
#6
Yanhai Xi, Tingwang Jiang, Weiheng Wang, Jiangming Yu, Yang Wang, Xueming Wu, Yunfei He
Intervertebral disc degeneration (IDD) is associated with the deterioration of nucleus pulposus (NP) cells due to hypertrophic differentiation and calcification. Emerging studies have shown that long noncoding RNAs (lncRNAs) play critical roles in the development of IDD. Using bioinformatics prediction, we hereby sought to identify the lncRNAs that regulate the expression of microRNA-146a-5p (miR-146a-5p), an IDD-related inflammatory factor. Our study demonstrated that lncRNA HCG18 acted as an endogenous sponge to down-regulate miR-146a-5p expression in the NP cells by directly binding to miR-146a-5p...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29019806/lumbar-vertebral-endplate-defects-on-magnetic-resonance-images-classification-distribution-patterns-and-associations-with-modic-changes-and-disc-degeneration
#7
Zhiyun Feng, Yuanhao Liu, Ge Yang, Michele C Battié, Yue Wang
STUDY DESIGN: A cross-sectional MR imaging study. OBJECTIVE: To classify and characterize endplate defects using routine lumbar MR images, and to determine associations of endplate defects with Modic Changes (MCs) and disc degeneration. SUMMARY OF BACKGROUND DATA: Previously, a cadaveric study revealed that endplate lesions were common and associated with back pain history. New in vivo approaches appropriate for clinical studies are needed to further this potentially important line of research on the clinical significance of endplate lesions, including their relation with MCs, disc degeneration and back pain...
October 10, 2017: Spine
https://www.readbyqxmd.com/read/28938891/treatment-of-lumbar-degenerative-disc-disease-associated-radicular-pain-with-culture-expanded-autologous-mesenchymal-stem-cells-a-pilot-study-on-safety-and-efficacy
#8
Christopher Centeno, Jason Markle, Ehren Dodson, Ian Stemper, Christopher J Williams, Matthew Hyzy, Thomas Ichim, Michael Freeman
BACKGROUND: Degenerative disc disease (DDD) is a common cause of lower back pain with radicular symptoms and has a significant socioeconomic impact given the associated disability. Limited effective conservative therapeutic options result in many turning to surgical alternatives for management, which vary in the rate of success and also carry an increased risk of morbidity and mortality associated with the procedures. Several animal based studies and a few human pilot studies have demonstrated safety and suggest efficacy in the treatment of DDD with mesenchymal stem cells (MSCs)...
September 22, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28934798/clinical-course-of-cervical-percutaneous-epidural-neuroplasty-in-single-level-cervical-disc-disease-with-12-month-follow-up
#9
Chang Hyun Oh, Gyu Yeul Ji, Dong Ah Shin, Pyung Goo Cho, Seung Hwan Yoon
BACKGROUND: Cervical disc disease is a common and occasionally disabling condition, occurring as a natural consequence of aging in the vast majority of the adult population. Percutaneous epidural neuroplasty (PEN) has been used to deliver highly concentrated drugs for chronic neck pain and to prevent scarring in cases refractory to conventional epidural blocks. However, the clinical course after PEN in cervical disc disease is not well-documented. OBJECTIVE: The purpose of this study was to evaluate the efficacy of cervical PEN for single-level cervical disc disease...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28934161/improving-the-process-of-adjusting-the-parameters-of-finite-element-models-of-healthy-human-intervertebral-discs-by-the-multi-response-surface-method
#10
Fátima Somovilla Gómez, Rubén Lostado Lorza, Marina Corral Bobadilla, Rubén Escribano García
The kinematic behavior of models that are based on the finite element method (FEM) for modeling the human body depends greatly on an accurate estimate of the parameters that define such models. This task is complex, and any small difference between the actual biomaterial model and the simulation model based on FEM can be amplified enormously in the presence of nonlinearities. The current paper attempts to demonstrate how a combination of the FEM and the MRS methods with desirability functions can be used to obtain the material parameters that are most appropriate for use in defining the behavior of Finite Element (FE) models of the healthy human lumbar intervertebral disc (IVD)...
September 21, 2017: Materials
https://www.readbyqxmd.com/read/28822738/a-study-of-the-damage-behaviour-of-porcine-intervertebral-discs-in-a-bioreactor-environment
#11
M Azarnoosh, M Stoffel, B Markert
The intervertebral discs are cartilaginous, articulating structures that lie between vertebral bodies, allowing flexibility, transmission, modification, and also distribution of the forces to the spinal column. Disc degeneration is characterised by progressive loss of disc height and exaggerated radial bulging. Therefore, the spine becomes shorter, stiffer, and less mobile. In the last several decades, there is a strong need for a tissue engineering strategy that alleviates pain and restores spine function by directly addressing the underlying biological causes of disc degeneration...
August 9, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28781913/nursing-review-section-of-surgical-neurology-international-evaluation-of-cervical-disc-disease-and-when-surgery-is-warranted
#12
REVIEW
Nancy E Epstein, Renee D Hollingsworth
BACKGROUND: Patients with cervical disc disease may present with radiculopathy (root compression), myelopathy (cord compression), or myeloradiculopathy. These complaints must be correlated with x-ray, magnetic resonance (MR) imaging, and computed tomographic (CT) scans. Although most patients can be managed nonsurgically, those with significant neurological deficits and larger disc herniations may require surgery. METHODS: The symptoms of cervical radiculopathy include pain radiating down one or both arms, while myelopathy may result in more diffuse numbness tingling or weakness in the upper and/or lower extremities...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28781912/nursing-review-section-of-surgical-neurology-international-part-1-lumbar-disc-disease
#13
Nancy E Epstein, Renee D Hollingsworth
BACKGROUND: Patients with lumbar disc disease may present with low back pain, pain that radiates down into the lower extremity (radiculopathy), and leg pain that increases with ambulation (neurogenic claudication). Patients may first undergo diagnostic studies [(magnetic resonance imaging (MRI) and computed tomographic (CT) examinations] to determine whether there is any significant nerve root or thecal sac compression. METHODS: Increasingly, patients with low back pain with/without radiculopathy are being screened by nurses rather than by neurologists or neurosurgeons/orthopedists...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28772379/determination-of-material-strengths-by-hydraulic-bulge-test
#14
Hankui Wang, Tong Xu, Binan Shou
The hydraulic bulge test (HBT) method is proposed to determine material tensile strengths. The basic idea of HBT is similar to the small punch test (SPT), but inspired by the manufacturing process of rupture discs-high-pressure hydraulic oil is used instead of punch to cause specimen deformation. Compared with SPT method, the HBT method can avoid some of influence factors, such as punch dimension, punch material, and the friction between punch and specimen. A calculation procedure that is entirely based on theoretical derivation is proposed for estimate yield strength and ultimate tensile strength...
December 30, 2016: Materials
https://www.readbyqxmd.com/read/28733922/effect-of-collagen-fibre-orientation-on-intervertebral-disc-torsion-mechanics
#15
Bo Yang, Grace D O'Connell
The intervertebral disc is a complex fibro-cartilaginous material, consisting of a pressurized nucleus pulposus surrounded by the annulus fibrosus, which has an angle-ply structure. Disc injury and degeneration are noted by significant changes in tissue structure and function, which significantly alters stress distribution and disc joint stiffness. Differences in fibre orientation are thought to contribute to changes in disc torsion mechanics. Therefore, the objective of this study was to evaluate the effect of collagen fibre orientation on internal disc mechanics under compression combined with axial rotation...
December 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28664021/abdominal-flank-bulging-after-lateral-retroperitoneal-approach-a-case-report
#16
Jeong-Hoon Choi, Jee-Soo Jang, Il-Tae Jang
The lateral transpsoas approach to access the vertebrae obviates the need for an approach surgeon and minimizes muscular disruption, thus allowing for quicker recovery. Several reports on the lateral transpsoas procedure have described few complications. However, the development of an unsightly and painful abdominal flank bulge is a largely under-recognized and very rare complication of the lateral transpsoas approach. A 59-year-old man suffered from back pain and bilateral posterior leg pain. Computed tomography (CT) scan and MRI showed retrolisthesis at L3-4, L2 wedge vertebrae with kyphosis, left L4 screw loosening, and L3-4 disc herniation with central canal stenosis...
January 2017: NMC Case Report Journal
https://www.readbyqxmd.com/read/28663652/clonidine-as-an-adjuvant-in-fluoroscopic-guided-transforaminal-epidural-steroid-injection-in-a-patient-of-chronic-lumbosacral-radiculopathy
#17
Nandita Mehta, Misbah Salaria, A Q Salaria
Transforaminal epidural steroid injection (TFESI) is a minimally invasive modality used to treat patients with lumbosacral radiculopathy secondary to prolapsed intervertebral disc or spinal canal stenosis. In this case report, we describe the management of a patient with chronic lumbosacral radiculopathy secondary to intervertebral disc herniation which was seen as a right paracentral disc protrusion at levels L4-L5, L5-S1 causing thecal sac indentation, effacement of the right lateral recess and right exiting nerve root impingement as was seen on the magnetic resonance image...
April 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28625905/influence-of-magnetic-resonance-imaging-features-on-surgical-decision-making-in-degenerative-cervical-myelopathy-results-from-a-global-survey-of-aospine-international-members
#18
Aria Nouri, Allan R Martin, Anick Nater, Christopher D Witiw, So Kato, Lindsay Tetreault, Hamed Reihani-Kermani, Carlo Santaguida, Michael G Fehlings
OBJECTIVE: We conducted a survey to understand how specific pathologic features on magnetic resonance imaging (MRI) influence surgeons toward an anterior or posterior surgical approach in degenerative cervical myelopathy (DCM). METHODS: A questionnaire was sent out to 6179 AOSpine International members via e-mail. This included 18 questions on a 7-point Likert scale regarding how MRI features influence the respondent's decision to perform an anterior or posterior surgical approach...
September 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28606581/the-effect-of-single-level-disc-degeneration-on-dynamic-response-of-the-whole-lumbar-spine-to-vertical-vibration
#19
Li-Xin Guo, Wei Fan
OBJECTIVE: The objective of this study was to investigate the effect of single-level disc degeneration on dynamic response of the whole lumbar spine to vertical whole body vibration that is typically present when driving vehicles. METHODS: Ligamentous finite element models of the lumbar L1-S1 motion segment in different grades of degeneration (healthy, mild, and moderate) at the L4-L5 level were developed with consideration of changing disc height and material properties of the nucleus pulpous...
September 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28576456/clinical-fundoscopic-tomographic-and-angiographic-characteristics-of-dome-shaped-macula-classified-by-bulge-height
#20
J Fajardo Sánchez, C E Chau Ramos, J A Roca Fernández, J L Urcelay Segura
OBJECTIVE: To classify dome shaped macula cases by their bulge height (BH). To analyse the characteristics associated with the groups formed by this classification. METHODS: Observational, descriptive and cross-sectional study on 15 selected eyes with dome shaped macula and high myopia. Using Caillaux method and optical coherence tomography images, 3groups were determined by their BH: low (50-350 μ), medium (351-650 μ), and high (>650 μ), and a study of visual acuity, axial length, presence of subfoveal serous detachment, and images by fluorescein angiography and optic coherence tomography, as main variables...
May 30, 2017: Archivos de la Sociedad Española de Oftalmología
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