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https://www.readbyqxmd.com/read/29629185/evaluation-of-spine-mris-in-athletes-participating-in-the-rio-de-janeiro-2016-summer-olympic-games
#1
Michael S Wasserman, Ali Guermazi, Mohamed Jarraya, Lars Engbretsen, Mohamad AbdelKader, Frank W Roemer, Daichi Hayashi, Michel D Crema, Asim Z Mian
Background/aim: In high-level Olympic athletes, many spinal pathologies arise from overuse, while others are the result of acute injury. Our aim is to analyse the epidemiology of spinal pathologies detected on MRI in athletes participating in the 2016 Rio de Janeiro Summer Olympics. Methods: In this retrospective study, all spine MRIs performed during the 2016 Rio Games were analysed. Descriptive data from the MRIs were tabulated and analysed for disc degeneration, spinal canal and/or neural foraminal narrowing, and acute/chronic fractures...
2018: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/29625464/safety-studies-for-a-44-channel-suprachoroidal-retinal-prosthesis-a-chronic-passive-study
#2
Carla J Abbott, David A X Nayagam, Chi D Luu, Stephanie B Epp, Richard A Williams, Cesar M Salinas-LaRosa, Joel Villalobos, Ceara McGowan, Mohit N Shivdasani, Owen Burns, Jason Leavens, Jonathan Yeoh, Alice A Brandli, Patrick C Thien, Jenny Zhou, Helen Feng, Chris E Williams, Robert K Shepherd, Penelope J Allen
Purpose: Following successful clinical outcomes of the prototype suprachoroidal retinal prosthesis, Bionic Vision Australia has developed an upgraded 44-channel suprachoroidal retinal prosthesis to provide a wider field of view and more phosphenes. The aim was to evaluate the preclinical passive safety characteristics of the upgraded electrode array. Methods: Ten normal-sighted felines were unilaterally implanted with an array containing platinum electrodes (44 stimulating and 2 returns) on a silicone carrier near the area centralis...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29606725/sacrocaudal-sacrococcygeal-intervertebral-disc-protrusion-in-2-cats
#3
Gianluca Magi, Giunio Bruto Cherubini, Olivier Taeymans
One cat was presented for investigation of urinary retention and constipation and a second cat was presented with decreased appetite, reluctance to jump, reduced level of activity, and constipation. Magnetic resonance imaging revealed dorsal bulging of the hypo-intense intervertebral disc at S3-Cd1 on fast spin echo T2. Dorsal laminectomy was performed and both cats recovered with resolution of neurological signs.
April 2018: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/29605701/the-role-of-posterior-screw-fixation-in-single-level-transforaminal-lumbar-interbody-fusion-during-whole-body-vibration-a-finite-element-study
#4
Wei Fan, Li-Xin Guo
OBJECTIVE: Very few studies have evaluated the need for supplementary instrumentation after lumbar interbody fusion under the condition of whole body vibration (WBV) that is typically present in vehicles. This study aimed to determine the effect of posterior pedicle screw fixation on dynamic response of the whole lumbar spine to vertical WBV after transforaminal lumbar interbody fusion (TLIF). METHODS: A previously validated non-linear, osteoligamentous finite element (FE) model of the intact L1-sacrum human lumbar spine was modified to simulate single-level (L4-L5) TLIF without and with bilateral pedicle screw fixation (BPSF)...
March 29, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29593901/frequent-benign-nontraumatic-noninflammatory-causes-of-low-back-pain-in-adolescents-mri-findings
#5
Aikaterini Solomou, Pantelis Kraniotis, Aspasia Rigopoulou, Theodore Petsas
Introduction: Low back pain (LBP) is common in children and adolescents. There are many factors that cause LBP, including structural disorders, degenerative changes, Scheuermann's disease, fractures, inflammation, and tumors. Magnetic Resonance Imaging is the gold standard for diagnosing spinal abnormalities and is mandatory when neurological symptoms exist. The study focuses on common MRI findings in adolescents with persistent LBP, without history of acute trauma or evidence of either inflammatory or rheumatic disease...
2018: Radiology Research and Practice
https://www.readbyqxmd.com/read/29467092/the-effect-of-computer-assisted-reporting-on-interreader-variability-of-lumbar-spine-mri-degenerative-findings-five-readers-with-30-disc-levels
#6
Benjamin Wang, Daniel I Rosenthal, Chun Xu, Pari V Pandharipande, H Benjamin Harvey, Tarik K Alkasab, Ambrose J Huang
PURPOSE: The aim of this study was to assess differences in interreader variability among radiologists after the implementation of a computer-assisted reporting (CAR) tool for the interpretation of degenerative disc disease on lumbar spine MRI. METHODS: Thirty lumbar spine MRI examinations were selected from the radiology database. Five fellowship-trained musculoskeletal radiologists evaluated each L4-L5 disc in a blinded fashion and reported the findings using a traditional free dictation approach...
February 19, 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29429465/-effect-of-vitamin-a-as-an-adjuvant-therapy-for-pneumonia-in-children-a-meta-analysis
#7
Nan Hu, Qu-Bei Li, Shan-Ye Zou
OBJECTIVE: To investigate the effect and safety of vitamin A supplementation in children with pneumonia through a systematic review. METHODS: Cochrane Library, EMbase, PubMed, China Biology Medicine disc, CNKI, and Wanfang Data were searched for randomized controlled trials (RCTs) on vitamin A as an adjuvant therapy for pneumonia in children. Two reviewers independently screened the studies and evaluated their quality according to the inclusion and exclusion criteria...
February 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29401181/retinal-nerve-fiber-layer-protrusion-associated-with-tilted-optic-discs
#8
Jaclyn Chiang, Michael Yapp, Angelica Ly, Michael P Hennessy, Michael Kalloniatis, Barbara Zangerl
SIGNIFICANCE: This study resulted in the identification of an optic nerve head (ONH) feature associated with tilted optic discs, which might potentially contribute to ONH pathologies. Knowledge of such findings will enhance clinical insights and drive future opportunities to understand disease processes related to tilted optic discs. PURPOSE: The aim of this study was to identify novel retinal nerve fiber layer (RNFL) anomalies by evaluating tilted optic discs using optical coherence tomography...
February 3, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29390319/the-influence-of-artificial-nucleus-pulposus-replacement-on-stress-distribution-in-the-cartilaginous-endplate-in-a-3-dimensional-finite-element-model-of-the-lumbar-intervertebral-disc
#9
Yu Wang, Xiao-Dong Yi, Chun-De Li
OBJECTIVE: This study aimed to investigate the effects involved with the artificial nucleus pulposus (NP) replacement on stress distribution of the cartilaginous endplate (CEP) in a 3-dimensional lumbar intervertebral disc (IVD) model using a finite element (FE) analysis. METHODS: A healthy male volunteer was recruited for the purposes of the study and a spiral computed tomography scan was subsequently conducted to obtain the data information in relation to the L4/5 motion segment...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29248773/spine-surgery-complicated-by-an-engorged-lumbar-epidural-venous-plexus-from-cerebrospinal-fluid-overshunting-a-case-report-and-review-of-the-literature
#10
Vance L Fredrickson, Arati Patel, Martin H Pham, Ben A Strickland, Ifije Ohiorhenuan, Thomas Chen
BACKGROUND: Overshunting of cerebrospinal fluid may lead to intracranial hypotension and dilation of spinal epidural veins. Radiculopathy may rarely occur secondary to engorged spinal epidural veins. In addition, the cause of radiculopathy may be obscured by concomitant spinal degenerative changes. We present a case and review the pathogenesis as well as the current clinical literature. CASE DESCRIPTION: A 29-year-old woman presented with positional headaches from intracranial hypotension in the setting of cerebrospinal fluid overshunting...
March 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29229402/full-field-strain-distribution-in-multi-vertebra-spine-segments-an-in-vitro-application-of-digital-image-correlation
#11
Marco Palanca, Miguel Marco, Maria Luisa Ruspi, Luca Cristofolini
The biomechanics of the spine is experimentally assessed in terms of range of motion and overall stiffness. Quantification of the surface strain distribution is currently limited either to the vertebrae or the discs, whereas a full-field approach to measure the strain distribution in a multi-vertebra segment is currently missing. The aim of this work was to explore the feasibility of using Digital Image Correlation (DIC) to measure the strain distribution simultaneously on the vertebral bodies and the intervertebral discs of spine segments in different loading configurations...
February 2018: Medical Engineering & Physics
https://www.readbyqxmd.com/read/29202297/finite-element-investigation-of-the-effect-of-nucleus-removal-on-vibration-characteristics-of-the-lumbar-spine-under-a-compressive-follower-preload
#12
Wei Fan, Li-Xin Guo
Previous studies have reported the effect of removing the nucleus on biomechanical responses of the human spine to static loadings. However, few studies have dealt with the whole-body vibration condition. The purpose of this study was to investigate the effect of a single-level (L4-L5) nucleus removal on vibration characteristics of the whole lumbar spine in the presence of a physiologic compressive preload, and also to evaluate the preload effect on the vibration characteristics. A 3-D non-linear finite element model of the lumbar spine (L1 to sacrum) subjected to the physiologic conditions of a compressive follower preload was developed and validated...
February 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29154999/kinematic-analysis-of-the-space-available-for-cord-and-disc-bulging-of-the-thoracic-spine-using-kinematic-magnetic-resonance-imaging-kmri
#13
Permsak Paholpak, Ishan Shah, Lou-Anne Acevedo-Moreno, Koji Tamai, Jeffrey C Wang, Zorica Buser
BACKGROUND CONTEXT: The thoracic spine was previously known as a relatively stable region in human spine. Several studies reported that the motion of the thoracic spine and changes in the cross-sectional area of the spinal cord changed with positions in the sagittal plane. The kinematic relationship between the thoracic disc and the space available for cord (SAC) with the positional change is still not well investigated. PURPOSE: The objective of this study was to evaluate the kinematic change of the intervertebral disc and space available for the spinal cord of the thoracic spine using kinematic magnetic resonance imaging (kMRI)...
November 14, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29147797/is-it-appropriate-to-measure-age-related-lumbar-disc-degeneration-on-the-mid-sagittal-mr-image-a-quantitative-image-study
#14
Xiaojian Hu, Mingjian Chen, Jianjiang Pan, Liang Liang, Yue Wang
PURPOSE: Even though phenotypes of disc degeneration vary on different sagittal magnetic resonance images (MRI), measurements typically are acquired on the mid-sagittal MRI. This study investigated the appropriateness of using the mid-sagittal MRI to measure various phenotypes of age-related disc degeneration. METHODS: Lumbar spine MRIs of 66 subjects (mean age 50.3 years, standard deviation 16.5 years, range 22-84 years) were studied. An image analysis program Spine Explorer was used to obtain quantitative measurements for disc height, bulging, and signal on para- and mid-sagittal T2-weighted MRIs...
November 17, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29141001/the-associations-between-magnetic-resonance-imaging-findings-and-low-back-pain-a-10-year-longitudinal-analysis
#15
Juichi Tonosu, Hiroyuki Oka, Akiro Higashikawa, Hiroshi Okazaki, Sakae Tanaka, Ko Matsudaira
PURPOSE: To conduct a 10-year longitudinal analysis of the relationship between magnetic resonance imaging (MRI) findings and low back pain (LBP). MATERIALS AND METHODS: Ninety-one volunteers with a history of LBP, but without current LBP were recruited between 2005 and 2006. Participants' baseline demographics and MRI findings were recorded. All volunteers were invited for a follow-up MRI in 2016; of these, 49 volunteers (53.8%) participated in the follow-up. We enquired whether they had LBP history during the 10 years between the baseline and follow-up examinations...
2017: PloS One
https://www.readbyqxmd.com/read/29038477/long-non-coding-hcg18-promotes-intervertebral-disc-degeneration-by-sponging-mir-146a-5p-and-regulating-traf6-expression
#16
Yanhai Xi, Tingwang Jiang, Weiheng Wang, Jiangming Yu, Yang Wang, Xueming Wu, Yunfei He
Intervertebral disc degeneration (IDD) is associated with the deterioration of nucleus pulposus (NP) cells due to hypertrophic differentiation and calcification. Emerging studies have shown that long noncoding RNAs (lncRNAs) play critical roles in the development of IDD. Using bioinformatics prediction, we hereby sought to identify the lncRNAs that regulate the expression of microRNA-146a-5p (miR-146a-5p), an IDD-related inflammatory factor. Our study demonstrated that lncRNA HCG18 acted as an endogenous sponge to down-regulate miR-146a-5p expression in the NP cells by directly binding to miR-146a-5p...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29019806/lumbar-vertebral-endplate-defects-on-magnetic-resonance-images-classification-distribution-patterns-and-associations-with-modic-changes-and-disc-degeneration
#17
Zhiyun Feng, Yuanhao Liu, Ge Yang, Michele C Battié, Yue Wang
STUDY DESIGN: A cross-sectional MR imaging study. OBJECTIVE: To classify and characterize endplate defects using routine lumbar MR images, and to determine associations of endplate defects with Modic Changes (MCs) and disc degeneration. SUMMARY OF BACKGROUND DATA: Previously, a cadaveric study revealed that endplate lesions were common and associated with back pain history. New in vivo approaches appropriate for clinical studies are needed to further this potentially important line of research on the clinical significance of endplate lesions, including their relation with MCs, disc degeneration and back pain...
October 10, 2017: Spine
https://www.readbyqxmd.com/read/28938891/treatment-of-lumbar-degenerative-disc-disease-associated-radicular-pain-with-culture-expanded-autologous-mesenchymal-stem-cells-a-pilot-study-on-safety-and-efficacy
#18
Christopher Centeno, Jason Markle, Ehren Dodson, Ian Stemper, Christopher J Williams, Matthew Hyzy, Thomas Ichim, Michael Freeman
BACKGROUND: Degenerative disc disease (DDD) is a common cause of lower back pain with radicular symptoms and has a significant socioeconomic impact given the associated disability. Limited effective conservative therapeutic options result in many turning to surgical alternatives for management, which vary in the rate of success and also carry an increased risk of morbidity and mortality associated with the procedures. Several animal based studies and a few human pilot studies have demonstrated safety and suggest efficacy in the treatment of DDD with mesenchymal stem cells (MSCs)...
September 22, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28934798/clinical-course-of-cervical-percutaneous-epidural-neuroplasty-in-single-level-cervical-disc-disease-with-12-month-follow-up
#19
Chang Hyun Oh, Gyu Yeul Ji, Dong Ah Shin, Pyung Goo Cho, Seung Hwan Yoon
BACKGROUND: Cervical disc disease is a common and occasionally disabling condition, occurring as a natural consequence of aging in the vast majority of the adult population. Percutaneous epidural neuroplasty (PEN) has been used to deliver highly concentrated drugs for chronic neck pain and to prevent scarring in cases refractory to conventional epidural blocks. However, the clinical course after PEN in cervical disc disease is not well-documented. OBJECTIVE: The purpose of this study was to evaluate the efficacy of cervical PEN for single-level cervical disc disease...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28934161/improving-the-process-of-adjusting-the-parameters-of-finite-element-models-of-healthy-human-intervertebral-discs-by-the-multi-response-surface-method
#20
Fátima Somovilla Gómez, Rubén Lostado Lorza, Marina Corral Bobadilla, Rubén Escribano García
The kinematic behavior of models that are based on the finite element method (FEM) for modeling the human body depends greatly on an accurate estimate of the parameters that define such models. This task is complex, and any small difference between the actual biomaterial model and the simulation model based on FEM can be amplified enormously in the presence of nonlinearities. The current paper attempts to demonstrate how a combination of the FEM and the MRS methods with desirability functions can be used to obtain the material parameters that are most appropriate for use in defining the behavior of Finite Element (FE) models of the healthy human lumbar intervertebral disc (IVD)...
September 21, 2017: Materials
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