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Degenerated Disc Disease

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https://www.readbyqxmd.com/read/29028103/expressions-of-il-1%C3%AE-and-mmp-9-in-degenerated-lumbar-disc-tissues-and-their-clinical-significance
#1
P-B Li, W-J Tang, K Wang, K Zou, B Che
OBJECTIVE: To observe the expression levels of interleukin-1α (IL-1α) and matrix metalloproteinase-9 (MMP-9) in degenerated lumbar disc tissues and to investigate their clinical significance. PATIENTS AND METHODS: Fifty patients with lumbar disc degeneration received the operative treatment were divided into three groups according to the magnetic resonance imaging (MRI) results: protrusion group, extrusion group, and free group. The degenerated intervertebral disc tissues were taken, and the normal intervertebral disc tissues of 20 patients received the operative treatment due to lumbar bursting fracture, and were selected as the control group...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29019878/a-comparison-of-anterior-cervical-discectomy-and-fusion-combined-with-cervical-disc-arthroplasty-and-cervical-disc-arthroplasty-for-the-treatment-of-skip-level-cervical-degenerative-disc-disease-a-retrospective-study
#2
Ting-Kui Wu, Bei-Yu Wang, Ming-Dan Deng, Ying Hong, Xin Rong, Hua Chen, Yang Meng, Hao Liu
Anterior cervical discectomy and fusion (ACDF) has been widely performed for the treatment of multilevel cervical degenerative disc disease (CDDD). In recent decades, cervical disc arthroplasty (CDA) and hybrid surgery (HS) have been developed to overcome the shortcomings of ACDF. Controversy still remains with regard to the optimal surgical procedure for skip-level CDDD.A total of 55 patients who received surgical treatment for skip-level CDDD in our department were reviewed. The patients were divided into the HS group (n = 29) and the CDA group (n = 26)...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29019591/x-ray-dynamic-observation-of-cervical-degenerative-disease-induced-by-unbalanced-dynamic-and-static-forces-in-rats-1
#3
Hua Xie, Yongjing Huang, Luming Nong, Nanwei Xu, Gongming Gao, Dong Zhou
PURPOSE: To investigate dynamically the X-ray appearance of cervical degenerative disease induced by unbalanced dynamic and static forces in rats. METHODS: A total of 60 Sprague Dawley rats were randomized into test (n=45) and control (n=15) groups, which were randomly subdivided into the one-, three- and six-month post-operative groups. The test group included 10, 15 and 20 rats at the respective corresponding post-operative stage and the control group included five rats at each time-point...
September 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28986691/spinal-motion-preservation-surgery-indications-and-applications
#4
REVIEW
Ioannis D Gelalis, Dimitrios V Papadopoulos, Dionysios K Giannoulis, Andreas G Tsantes, Anastasios V Korompilias
Fusion is one of the most commonly performed spinal procedures, indicated for a wide range of spinal problems. Elimination of motion though results in accelerated degeneration of the adjacent level, known as adjacent level disease. Motion preservation surgical methods were developed in order to overcome this complication. These methods include total disc replacement, laminoplasty, interspinous implants and dynamic posterior stabilization systems. The initial enthusiasm about these methods was followed by certain concerns about their clinical usefulness and their results...
October 6, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28970490/mast-cell-intervertebral-disc-cell-interactions-regulate-inflammation-catabolism-and-angiogenesis-in-discogenic-back-pain
#5
Matthew G Wiet, Andrew Piscioneri, Safdar N Khan, Megan N Ballinger, Judith A Hoyland, Devina Purmessur
Low back pain (LBP) is a widespread debilitating disorder of significant socio-economic importance and intervertebral disc (IVD) degeneration has been implicated in its pathogenesis. Despite its high prevalence the underlying causes of LBP and IVD degeneration are not well understood. Recent work in musculoskeletal degenerative diseases such as osteoarthritis have revealed a critical role for immune cells, specifically mast cells in their pathophysiology, eluding to a potential role for these cells in the pathogenesis of IVD degeneration...
October 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28962127/multimodal-quantitative-magnetic-resonance-imaging-for-lumbar-intervertebral-disc-degeneration
#6
Wei Wang, Jin Hou, Deyong Lv, Wen Liang, Xinqing Jiang, Hongbin Han, Xianyue Quan
The present study investigated the application of the T1ρ and T2 relaxation mapping magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) in the evaluation of intervertebral disc degeneration (IDD). A total of 93 asymptomatic subjects were imaged with T1ρ and T2 mapping, as well as DWI. Pfirrmann grading was performed and correlation analysis was conducted for T1ρ, T2 and DWI results with the grading results and age. Pfirrmann grading indicated 69 cases of grade I, 240 cases of grade II, 101 cases of grade III, 43 cases of grade IV and 12 cases of grade V...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28944876/nutrient-deprivation-induces-apoptosis-of-nucleus-pulposus-cells-via-activation-of-the-bnip3-aif-signalling-pathway
#7
Jie Liu, Chao Yuan, Luqiao Pu, Jian Wang
Nutrient deprivation (ND)‑induced nucleus pulposus (NP) cell death serves an important role in intervertebral disc degeneration disease. However, the underlying mechanisms have yet to be thoroughly elucidated. The present study created a cell culture model under ND conditions to investigate the roles of the nutrient‑sensitive protein B‑cell lymphoma 2/adenovirus E1B 19 kDa‑interacting protein (BNIP3) and the mitochondrial pro‑death protein apoptosis‑inducing factor (AIF) in the death pathway of NP cells...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28941528/dominant-optic-atrophy-and-leber-s-hereditary-optic-neuropathy-update-on-clinical-features-and-current-therapeutic-approaches
#8
Bo Young Chun, Joseph F Rizzo
Dominant optic atrophy (DOA) and Leber hereditary optic neuropathy (LHON) are the two most common inherited optic neuropathies encountered in clinical practice. This review provides a summary of recent advances in the understanding of the clinical manifestations, current treatments, and ongoing clinical trials of these two optic neuropathies. Substantial progress has been made in the understanding of the clinical, genetic, and pathophysiological basis of DOA and LHON. Pathogenic OPA1 gene mutations in DOA and 3 primary mutations of mitochondrial DNA in LHON-induced mitochondrial dysfunction, which in turn leads to increased reactive oxygen species levels in mitochondria and possibly insufficient ATP production...
May 2017: Seminars in Pediatric Neurology
https://www.readbyqxmd.com/read/28938891/treatment-of-lumbar-degenerative-disc-disease-associated-radicular-pain-with-culture-expanded-autologous-mesenchymal-stem-cells-a-pilot-study-on-safety-and-efficacy
#9
Christopher Centeno, Jason Markle, Ehren Dodson, Ian Stemper, Christopher J Williams, Matthew Hyzy, Thomas Ichim, Michael Freeman
BACKGROUND: Degenerative disc disease (DDD) is a common cause of lower back pain with radicular symptoms and has a significant socioeconomic impact given the associated disability. Limited effective conservative therapeutic options result in many turning to surgical alternatives for management, which vary in the rate of success and also carry an increased risk of morbidity and mortality associated with the procedures. Several animal based studies and a few human pilot studies have demonstrated safety and suggest efficacy in the treatment of DDD with mesenchymal stem cells (MSCs)...
September 22, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28938108/cervical-arthroplasty-versus-anterior-cervical-fusion-for-symptomatic-adjacent-segment-disease-after-anterior-cervical-fusion-surgery-review-of-treatment-in-41-patients
#10
Sang-Bok Lee, Kyoung-Suok Cho
OBJECTIVE: The purpose of this study is to compare the efficacy and safety of anterior cervical discectomy and fusion (ACDF) and cervical total disc replacement (CTDR) as revision surgeries for symptomatic adjacent segment degeneration (ASD) in cases with previous ACDF. PATIENTS AND METHODS: Between 2010 and 2014, 41 patients with previous cervical fusion surgery underwent ACDF or CTDR for symptomatic ASD. Twenty-two patients in the ACDF group underwent 26 ACDFs, and 19 patients in the CTDR group underwent 25 arthroplasties for symptomatic ASD...
August 4, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28937877/changes-in-peripapillary-nerve-fiber-layer-thickness-after-adjuvant-stereotactic-radiotherapy-in-patients-with-neovascular-age-related-macular-degeneration
#11
Mahdy Ranjbar, Maximilian Kurz, Annekatrin Holzhey, Dirk Rades, Salvatore Grisanti
PURPOSE: To evaluate the effect of stereotactic radiotherapy (SRT) in conjunction with intravitreal injections (IVI) of anti-vascular endothelial growth factor (anti-VEGF) drugs on peripapillary retinal nerve fiber layer (pRNFL) thickness in patients with neovascular age-related macular degeneration (nAMD). METHODS: This was a retrospective, observational case series of patients with nAMD, who underwent SRT and subsequently had at least 12 months of complete follow-up...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28926646/vascular-hypoperfusion-in-acute-optic-neuritis-is-a-potentially-new-neurovascular-model-for-demyelinating-diseases
#12
Ta-Ching Chen, Chao-Yuan Yeh, Chao-Wen Lin, Chung-May Yang, Chang-Hao Yang, I-Hung Lin, Pao-Yang Chen, Jung-Yu Cheng, Fung-Rong Hu
PURPOSE: Optic neuritis is highly correlated with multiple sclerosis and is a major cause of acute visual loss and long-term neuronal degeneration. Primary cerebral hypoperfusion has been reported in brain demyelinating diseases. This study investigated whether peripapillary perfusion is changed in patients with acute optic neuritis (AON). METHODS: This three-year cohort study was conducted from September 1 2012, to August 31, 2015. Two hundred and forty-one patients with non-glaucomatous acute optic neuropathy were screened, and 42 non-highly myopic patients who had suffered their first episode of unilaterally idiopathic AON were studied...
2017: PloS One
https://www.readbyqxmd.com/read/28894375/impact-of-t1-slope-on-surgical-and-adjacent-segment-degeneration-after-bryan-cervical-disc-arthroplasty
#13
Peng Yang, Yongqian Li, Jia Li, Yong Shen
BACKGROUND: This retrospective study investigated an association between preoperative T1 slope and surgical and adjacent segment degeneration (SASD) after Bryan cervical disc arthroplasty (BCDA) in patients with cervical degenerative disc disease. METHODS: Based on preoperative standing lateral radiographs, 90 patients were classified according to T1 slope that was higher or lower than the 50th percentile (high T1 or low T1, 28 and 62 patients, respectively). Patients were also classified as SASD or non-SASD (38 and 52 patients, respectively) determined by radiographs at final follow-up...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28881110/endoscopic-spine-surgery
#14
REVIEW
Gun Choi, Chetan S Pophale, Bhupesh Patel, Priyank Uniyal
Surgical treatment of the degenerative disc disease has evolved from traditional open spine surgery to minimally invasive spine surgery including endoscopic spine surgery. Constant improvement in the imaging modality especially with introduction of the magnetic resonance imaging, it is possible to identify culprit degenerated disc segment and again with the discography it is possible to diagnose the pain generator and pathological degenerated disc very precisely and its treatment with minimally invasive approach...
September 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28870839/long-term-clinical-results-following-charite-iii-lumbar-total-disc-replacement
#15
Shibao Lu, Siyuan Sun, Chao Kong, Wenzhi Sun, Hailiang Hu, Qingyi Wang, Yong Hai
BACKGROUND CONTEXT: The lumbar total disc replacement (TDR) operation represents an alternative to lumbar fusion for the treatment of symptomatic lumbar intervertebral disc degeneration, and has gained increasing attention in recent years. PURPOSE: To assess clinical outcomes in a cohort of patients with TDR and the long-term survival rate of the prostheses. STUDY DESIGN: A retrospective, single-center clinical study. PATIENT SAMPLE: Thirty patients with a total of 35 prostheses after an average follow-up (FU) of 15...
September 1, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28845390/melatonin-modulates-prohibitin-and-cytoskeleton-in-the-retinal-pigment-epithelium
#16
Srinivas R Sripathi, Cameron L Prigge, Beth Elledge, Weilue He, Johnpaul Offor, Diana R Gutsaeva, Wan Jin Jahng
The retinal pigment epithelium (RPE) plays imperative roles in normal retinal function by photoreceptor protection from light and phagocytosis of rod and cone outer segments during disc shedding. Melatonin is the free radical scavenger and circadian determinant to protect the RPE and retina from oxidative stress and regulate the circadian clock. The current study tested the hypothesis whether melatonin could affect cytoskeletal structure within RPE. Our Western blot analysis demonstrated that melatonin treatment up-regulated prohibitin 3-fold compared to control...
July 2017: International Journal of Scientific and Engineering Research
https://www.readbyqxmd.com/read/28843706/variation-of-facet-joint-orientation-and-tropism-in-lumbar-degenerative-spondylolisthesis-and-disc-herniation-at-l4-l5-a-systematic-review-and-meta-analysis
#17
REVIEW
Ziyang Liu, Yuchen Duan, Xin Rong, Beiyu Wang, Hua Chen, Hao Liu
Although degenerative spondylolisthesis (DS) and lumber disc herniation (LDH) are common causes of back pain, the associations between the lumbar facet joint angle orientation and tropism in these conditions are still contentious. The objective of the meta-analysis was to identify the role of facet joint orientation and tropism on the development of lumbar degenerative disease, including DS and LDH. Electronic searches of PubMed and Embase were conducted up to April 2017. P value<0.05 was regarded as significant...
October 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28842479/tnf-%C3%AE-promotes-nuclear-enrichment-of-tonebp-nfat5-to-selectively-control-inflammatory-but-not-osmoregulatory-responses-in-nucleus-pulposus-cells
#18
Zariel I Johnson, Alexandra C Doolittle, Joseph W Snuggs, Irving M Shapiro, Christine L Le Maitre, Makarand V Risbud
Intervertebral disc degeneration (IDD) causes chronic back pain and is linked to production of proinflammatory molecules by nucleus pulposus (NP) and other disc cells. Activation of TonicityResponsive Enhancer-Binding Protein (TonEBP)/NFAT5 by non-osmotic stimuli, including pro-inflammatory molecules, occurs in cells involved in immune response. However, whether inflammatory stimuli activate TonEBP in NP cells and if TonEBP controls inflammation during IDD is unknown. We show that TNF-α, but not IL-1β or LPS, promoted nuclear enrichment of TonEBP protein...
August 25, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28816821/adjacent-segment-disease-after-cervical-spine-fusion-evaluation-of-a-70-patient-long-term-follow-up
#19
Mohamed Alhashash, Mootaz Shousha, Heinrich Boehm
STUDY DESIGN: A retrospective study of 70 patients undergoing surgical treatment for adjacent segment disease (ASD) after anterior cervical decompression and fusion (ACDF). OBJECTIVES: To analyze the risk factors for the development of ASD in patients who underwent ACDF. SUMMARY OF BACKGROUND DATA: ACDF has provided a high rate of clinical success for the cervical degenerative disc disease; nevertheless, adjacent segment degeneration has been reported as a complication at the adjacent level secondary to the rigid fixation...
August 14, 2017: Spine
https://www.readbyqxmd.com/read/28810570/research-on-the-function-and-related-mechanism-of-p27-gene-in-the-intervertebral-disc-degeneration-of-mice
#20
Xiao Liu, Deguo Wang, Zhengzheng Zhang, Fenghui Zhu, Aiming Yao, Jiwei Tian, Dengshun Miao
This study aims to investigate the function and related mechanism of P27 gene in intervertebral disc (IVD) degeneration of mice. X-ray, immunohistochemical staining, and alkaline phosphatase (ALP) histochemical staining were used to analyze the phenotypic difference of the intervertebral discs of 4-week-old mice with P27 gene knockout (P27(-/-)) and wild-type (WT) mice in the same brood. Protein in the intervertebral disc was extracted and western blot analysis was employed to detect the changes in the expression of related molecules in the Shh-signal pathways, including Shh, Patched, Smoothened and Gli2...
August 2017: Experimental and Therapeutic Medicine
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