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Degenerated Disc Disease

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https://www.readbyqxmd.com/read/29665815/a-comparison-of-zero-profile-anchored-spacer-roi-c-and-plate-fixation-in-2-level-noncontiguous-anterior-cervical-discectomy-and-fusion-a-retrospective-study
#1
Zongyu Zhang, Yawei Li, Weimin Jiang
BACKGROUND: Anterior cervical discectomy and fusion (ACDF) is the classic surgical treatment for symptomatic cervical degenerative disc disease (CDDD). However, there is controversy over the best surgical management in patients with two noncontiguous symptomatic levels of CDDD. METHODS: From April 2011 to May 2014, 44 patients with two noncontiguous symptomatic levels of CDDD underwent skip-level ACDFs. In Group NoPlate, 23 cases underwent 2 noncontiguous levels of ACDF using zero-profile anchored spacer; and in Group Plate, 21 cases underwent 2 noncontiguous levels of ACDF using cages and plates...
April 17, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29651107/circular-rna-circ-4099-is-induced-by-tnf-%C3%AE-and-regulates-ecm-synthesis-by-blocking-mir-616-5p-inhibition-of-sox9-in-intervertebral-disc-degeneration
#2
Hua Wang, Peiheng He, Hehai Pan, Jun Long, Jianru Wang, Zemin Li, Hui Liu, Weiying Jiang, Zhaomin Zheng
Circular RNAs (circRNAs) play important roles in the initiation and development of different diseases. Here, we detected their role in intervertebral disc (IVD) degeneration. An Arraystar human circular RNA microarray assay was used to detect circRNAs in normal and degenerated human IVD nucleus pulposus (NP) tissues. The role of circ-4099 in IVDD and its mechanism were evaluated by qRT-PCR and gain-of-function/loss-of-function studies. Interaction networks for competing endogenous RNAs (ceRNAs), miRNAs, and miRNA target gene were detected by bioinformatics analysis, RNA immunoprecipitation and luciferase assay...
April 13, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29649666/a-retrospective-study-does-cigarette-smoking-induce-cervical-disc-degeneration
#3
Zhaoxiong Chen, Xinhua Li, Fumin Pan, Desheng Wu, Haoxi Li
OBJECTIVE: To investigate cigarette smoking's relevance with cervical disc degeneration. METHODS: We randomly selected 320 patients who came to our spine disease department outpatient clinic with chief complaint of neck-shoulder pain during June 2014-June 2016. According to the detailed smoking history, these patients were divided into 3 different groups, which were active smoker group (AS), passive smoking group (PS) and never-smoker group (NS). Each patient's Miyazaki's magnetic resonance imaging (MRI) classification of cervical disc degeneration was analyzed based on their cervical MRI films...
April 9, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29649568/honokiol-alleviates-the-degeneration-of-intervertebral-disc-via-suppressing-the-activation-of-txnip-nlrp3-inflammasome-signal-pathway
#4
Pan Tang, Jia-Ming Gu, Zi-Ang Xie, Yu Gu, Zhi-Wei Jie, Kang-Mao Huang, Ji-Ying Wang, Shun-Wu Fan, Xue-Sheng Jiang, Zhi-Jun Hu
Intervertebral disc degeneration (IVDD) is a multifactorial disease and responsible for many spine related disorders, causes disability in the workforce and heavy social costs all over the world. Honokiol, a low molecular weight natural product, could penetrate into and distribute in IVDs to achieve therapeutic effect in a rat tail model. Therefore, the present study was undertaken to examine the antiinflammatory, antioxidation and chondroprotective effect of honokiol using nucleus pulposus cells and investigate its mechanisms to provide a new basis for future clinical treatment of IVDD...
April 9, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29629185/evaluation-of-spine-mris-in-athletes-participating-in-the-rio-de-janeiro-2016-summer-olympic-games
#5
Michael S Wasserman, Ali Guermazi, Mohamed Jarraya, Lars Engbretsen, Mohamad AbdelKader, Frank W Roemer, Daichi Hayashi, Michel D Crema, Asim Z Mian
Background/aim: In high-level Olympic athletes, many spinal pathologies arise from overuse, while others are the result of acute injury. Our aim is to analyse the epidemiology of spinal pathologies detected on MRI in athletes participating in the 2016 Rio de Janeiro Summer Olympics. Methods: In this retrospective study, all spine MRIs performed during the 2016 Rio Games were analysed. Descriptive data from the MRIs were tabulated and analysed for disc degeneration, spinal canal and/or neural foraminal narrowing, and acute/chronic fractures...
2018: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/29615017/clinical-and-radiographic-outcome-of-dynamic-cervical-implant-dci-arthroplasty-for-degenerative-cervical-disc-disease-a-minimal-five-year-follow-up
#6
Lin-Nan Wang, Bo-Wen Hu, Lei Wang, Yue-Ming Song, Xi Yang, Li-Min Liu, Hao Liu
BACKGROUND: To evaluate the mid- to long-term clinical and radiographic outcomes of anterior cervical discectomy and dynamic cervical implant (DCI) arthroplasty for degenerative cervical disc disease. METHODS: From April 2010 to October 2010, 38 patients with single- or double-level cervical disc herniation underwent anterior cervical discectomy and DCI arthroplasty. The clinical results and radiographic outcomes of these 38 patients (42 levels) were retrospectively evaluated...
April 4, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29605898/spondylolisthesis-adjacent-to-a-cervical-disc-arthroplasty-does-not-increase-the-risk-of-adjacent-level-degeneration
#7
David Christopher Kieser, Derek Thomas Cawley, Cecile Roscop, Simon Mazas, Pierre Coudert, Louis Boissiere, Ibrahim Obeid, Jean-Marc Vital, Vincent Pointillart, Olivier Gille
PURPOSE: To understand whether a spondylolisthesis in the sub-axial spine cranial to a cervical disc arthroplasty (CDA) construes a risk of adjacent level disease (ALD). METHODS: A retrospective review of 164 patients with a minimum 5-year follow-up of a cervical disc arthroplasty was performed. Multi-level surgeries, including hybrid procedures, were included. Multiple implant types were included. The two inter-vertebral discs (IVD) cranial of the CDA were monitored for evidence of radiologic degeneration using the Kettler criteria...
March 31, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29605718/a-novel-mouse-model-of-intervertebral-disc-degeneration-shows-altered-cell-fate-and-matrix-homeostasis
#8
Hyowon Choi, Steven Tessier, Elizabeth S Silagi, Rutvin Kyada, Farzad Yousefi, Nancy Pleshko, Irving M Shapiro, Makarand V Risbud
Intervertebral disc degeneration and associated low back and neck pain is a ubiquitous health condition that affects millions of people world-wide, and causes high incidence of disability and enormous medical/societal costs. However, lack of appropriate small animal models with spontaneous disease onset has impeded our ability to understand the pathogenetic mechanisms that characterize and drive the degenerative process. We report, for the first time, early onset spontaneous disc degeneration in SM/J mice known for their poor regenerative capacities compared to "super-healer" LG/J mice...
March 29, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29597025/stromal-cell-derived-factor-1%C3%AE-encapsulated-albumin-heparin-nanoparticles-for-induced-stem-cell-migration-and-intervertebral-disc-regeneration-in-vivo
#9
Hua Zhang, Shan Yu, Xinlian Zhao, Zhengwei Mao, Changyou Gao
Intervertebral disc (IVD) degeneration may cause many diseases and pain. Stem cell migration toward the site of IVD degeneration is a key factor for IVD regeneration. In the current study, we prepared albumin/heparin nanoparticles (BHNPs) as injectable carriers of stromal cell-derived factor-1α (SDF-1α, also known as C-X-C motif chemokine 12), a powerful chemoattractant for the homing of bone marrow resident mesenchymal stem cells (MSCs), for protection of the molecule against degradation for a sustained release...
March 26, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29575654/spermidine-promotes-nucleus-pulposus-autophagy-as-a-protective-mechanism-against-apoptosis-and-ameliorates-disc-degeneration
#10
Zengming Zheng, Zhou-Guang Wang, Yu Chen, Jian Chen, Sinan Khor, Jiawei Li, Zili He, Qingqing Wang, Hongyu Zhang, Ke Xu, Gong Fanghua, Jian Xiao, Xiangyang Wang
Spermidine has therapeutic effects in many diseases including as heart diastolic function, myopathic defects and neurodegenerative disorders via autophagy activation. Autophagy has been found to mitigate cell apoptosis in intervertebral disc degeneration (IDD). Accordingly, we theorize that spermidine may have beneficial effects on IDD via autophagy stimulation. In this study, spermidine's effect on IDD was evaluated in tert-butyl hydroperoxide (TBHP)-treated nucleus pulposus cells of SD rats in vitro as well as in a puncture-induced rat IDD model...
March 25, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29574862/high-amplitude-and-low-frequency-cyclic-mechanical-strain-promotes-degeneration-of-human-nucleus-pulposus-cells-via-the-nf-%C3%AE%C2%BAb-p65-pathway
#11
Shengjie Wang, Jie Li, Jiwei Tian, Zhenghong Yu, Kun Gao, Jia Shao, Ang Li, Shuai Xing, Yonghui Dong, Zhiyong Li, Yanzheng Gao, Liping Wang, Cory J Xian
Disc degeneration alters the structure and function of intervertebral discs and is the basis of spinal degenerative diseases. To establish the molecular mechanism of intervertebral disc degeneration caused by mechanical strain, this study examined the effects of different amplitude (3%, 9%, 19%) cyclic mechanical strain (CMS) at a low frequency (0.01 Hz) on the secretion of cartilage extracellular matrix, expression of inflammatory cytokines and catabolic proteases, and activation of NF-κB signaling pathway in human nucleus pulposus cells...
March 25, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29570121/progression-of-adjacent-level-degeneration-after-lumbar-total-disc-replacement-results-of-a-post-hoc-analysis-of-patients-with-available-radiographs-from-a-prospective-study-with-5-year-follow-up
#12
Jack E Zigler, Scott L Blumenthal, Richard D Guyer, Donna D Ohnmeiss, Leena Patel
STUDY DESIGN: Post-hoc analysis of 5-year follow-up data from a randomized, multicenter trial. OBJECTIVE: To investigate the incidence of progression in radiographic adjacent-level degeneration (ΔALD) from preoperative assessment to 5 years after total disc replacement (TDR) and the relationship of these changes with range of motion and clinical adjacent-level disease. A secondary objective was to compare ALD outcomes between TDR and fusion. SUMMARY OF BACKGROUND DATA: Fusion is associated with high rates of ALD in symptomatic lumbar disc degeneration...
March 21, 2018: Spine
https://www.readbyqxmd.com/read/29568524/novel-therapeutic-strategies-for-degenerative-disc-disease-review-of-cell-biology-and-intervertebral-disc-cell-therapy
#13
REVIEW
Joseph Fernandez-Moure, Caitlyn A Moore, Keemberly Kim, Azim Karim, Kevin Smith, Zonia Barbosa, Jeffrey Van Eps, Pranela Rameshwar, Bradley Weiner
Intervertebral disc degeneration is a disease of the discs connecting adjoining vertebrae in which structural damage leads to loss of disc integrity. Degeneration of the disc can be a normal process of ageing, but can also be precipitated by other factors. Literature has made substantial progress in understanding the biological basis of intervertebral disc, which is reviewed here. Current medical and surgical management strategies have shortcomings that do not lend promise to be effective solutions in the coming years...
2018: SAGE Open Medicine
https://www.readbyqxmd.com/read/29559335/golgi-bypass-of-ciliary-proteins
#14
REVIEW
Ralph Witzgall
Primary cilia represent small, yet distinct compartments of the plasma membrane. They are speculated to exercise chemo- and mechanosensory functions and to serve as signaling hubs for crucial pathways such as the Wnt and hedgehog cascades. It is therefore necessary that specific integral membrane proteins, in particular sensors and receptors, are sorted to the cilium and not to the surrounding somatic plasma membrane upon being synthesized at the rough endoplasmic reticulum. Apparently no singular "zip code" for the primary cilium exists but rather several ciliary targeting signals whose biochemical and cell biological implications are just about being unravelled...
March 24, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29555463/genipin-cross-linked-type-ii-collagen-chondroitin-sulfate-composite-hydrogel-like-cell-delivery-system-induces-differentiation-of-adipose-derived-stem-cells-and-regenerates-degenerated-nucleus-pulposus
#15
Xiaopeng Zhou, Jingkai Wang, Weijing Fang, Yiqing Tao, Tengfei Zhao, Kaishun Xia, Chengzhen Liang, Jianming Hua, Fangcai Li, Qixin Chen
Nucleus pulposus (NP) degeneration is usually the origin of intervertebral disc degeneration and consequent lower back pain. Although adipose-derived stem cell (ADSC)-based therapy is regarded to be promising for the treatment of degenerated NP, there is a lack of viable cell carriers to transplant ADSCs into the NP while maintaining cell function. In this study, we developed a type II collagen/chondroitin sulfate (CS) composite hydrogel-like ADSC (CCSA) delivery system with genipin as the cross-linking agent...
March 16, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29554650/dysregulated-mir-3150a-3p-promotes-lumbar-intervertebral-disc-degeneration-by-targeting-aggrecan
#16
Bin Zhang, Wei Guo, Chao Sun, Hui-Quan Duan, Bing-Bing Yu, Kun Mu, Yue-Yan Guan, Yan Li, Shen Liu, Yang Liu, De-Xiang Ban, Wen-Dong Ruan, Xiao-Hong Kong, Cong Xing, Guang-Zhi Ning, Shi-Qing Feng
BACKGROUND/AIMS: Low back pain has become one of the most common musculoskeletal diseases in the world. Studies have shown that intervertebral disc degeneration (IDD) is an important factor leading to low back pain, but the mechanisms underlying IDD remain largely unknown. Research over the past decade has suggested critical roles for microRNAs (miRNAs) in natural growth and disease progression. However, it remains poorly understood whether circular RNAs participate in IDD. METHODS: Clinical IDD samples were collected from 20 patients who underwent discectomy...
March 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29547460/comparison-of-6-year-follow-up-result-of-hybrid-surgery-and-anterior-cervical-discectomy-and-fusion-for-the-treatment-of-contiguous-2-segment-cervical-degenerative-disc-diseases
#17
Yang Xiong, Lin Xu, Xing Yu, Yongdong Yang, Dingyan Zhao, Zhengguo Hu, Chuanhong Li, He Zhao, Lijun Duan, Bingbing Zhang, Sixue Chen, Tao Liu
STUDY DESIGN: A retrospective study. OBJECTIVE: To compare the mid-term outcomes of hybrid surgery and anterior cervical discectomy and fusion for the treatment of contiguous 2-segment cervical degenerative disc diseases. SUMMARY OF BACKGROUND DATA: Hybrid surgery has become one of the most controversial subjects in spine communities, and the comparative studies of hybrid surgery and anterior cervical discectomy and fusion in the mid- and long-term follow-up are rarely reported...
March 15, 2018: Spine
https://www.readbyqxmd.com/read/29545889/overexpression-of-growth-and-differentiation-factor-5-inhibits-inflammatory-factors-released-by-intervertebral-disc-cells
#18
Lin Shen, Yinghua Wu, Liang Han, Haiying Zhang
Low back pain (LBP) is one of the most common musculoskeletal diseases in the world. The incidence is ~70% in adults and many of them suffer from disability. Recently, intervertebral disc degeneration (IDD) has been deemed as a main cause of LBP. The present study aimed to investigate the potentials of growth and differentiation factor-5 (GDF-5) in IDD. The protein levels of prostaglandin-E2 (PGE2), tumor necrosis factor (TNF)-α and interleukin (IL)-1β in culture medium were evaluated by ELISA. mRNA and protein expression levels in nucleus pulposus (NP) cells were evaluated by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blotting, respectively...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29534600/the-long-non-coding-rna-neat1-contributes-to-extracellular-matrix-degradation-in-degenerative-human-nucleus-pulposus-cells
#19
Zhi Ruan, Hui Ma, Jing Li, Huiyong Liu, Haoruo Jia, Feng Li
Intervertebral disc degeneration is a complex disease involving genetic and environmental factors and multiple cellular processes. The role and expression of the lncRNA NEAT1 were assessed in intervertebral disc degeneration. NEAT1 expression was assessed in degenerative and control nucleus pulposus using RT-PCR. Western blotting and RT-PCR were also used to investigate p53 and p21 levels in nucleus pulposus tissues. NEAT1 function in degenerative nucleus pulposus cells was assessed with gain- and loss-of-function experiments...
January 1, 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29529003/selective-anterior-lumbar-interbody-fusion-for-low-back-pain-associated-with-degenerative-disc-disease-versus-nonsurgical-management
#20
John P Kleimeyer, Ivan Cheng, Todd F Alamin, Serena S Hu, Thomas Cha, Vijay Yanamadala, Kirkham B Wood
STUDY DESIGN: This is a retrospective cohort study. OBJECTIVE: To evaluate the long-term outcomes of selective one- to two-level anterior lumbar interbody fusions (ALIFs) in the lower lumbar spine versus continued nonsurgical management. SUMMARY OF BACKGROUND DATA: Low back pain associated with lumbar intervertebral disc degeneration is common with substantial economic impact, yet treatment remains controversial. Surgical fusion has previously provided mixed results with limited durable improvement of pain and function...
March 9, 2018: Spine
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