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Degenerated Disc Disease

Chul-Hyun Kim, Jong Moon Hwang, Jin-Sung Park, Seungwoo Han, Donghwi Park
The aim of this study is to investigate the usefulness of flexion-extension (dynamic) radiographs in evaluating the severity of disc degeneration and disc protrusion in cervical magnetic resonance image (MRI). Patients complaining of neck or arm pain with no prior surgical history and who had undergone both cervical MRI and dynamic radiographs were included in this study. The following patients were excluded: those who had any history of trauma, autoimmune disease such as rheumatoid arthritis or ankylosing spondylitis, prior cervical fracture or prior cervical spine surgery...
June 2018: Medicine (Baltimore)
Yunus Emre Kundakci, Nadire Unver Dogan, Ibrahim Guler, Ismihan Ilknur Uysal, Zeliha Fazliogullari, Ahmet Kagan Karabulut
PURPOSE: We aimed to research in detail the morphology of the facet orientation (FO) and tropism (FT) in degenerative diseases. METHOD: This study consisted of patients with disc degeneration (DD) and with lumbar spondylolisthesis (LS) as well as a control group without these two diseases. The group of patients with DD was separated by DD grades. Vertebral body and intervertebral discs' (IVDs) morphometric values, facet joint osteoarthritis (OA) grading, FO and FT were examined in all the groups...
June 16, 2018: Surgical and Radiologic Anatomy: SRA
Yu Chen, Zengming Zheng, Jianle Wang, Chengxuan Tang, Sinan Khor, Jian Chen, Xibang Chen, Zengjie Zhang, Qian Tang, Chenggui Wang, Yiting Lou, Zhouguang Wang, Jian Xiao, Xiangyang Wang
Intervertebral disc degeneration (IVDD) is a chronic disease with complicated pathology involving nucleus pulposus (NP) cell apoptosis and extracellular matrix (ECM) degradation. Previous studies have shown that moderate autophagy has a protective effect against apoptosis in NP cells. Berberine (BBR) is an alkaloid compound with many beneficial properties including antimicrobial, anti-inflammatory, antioxidative, and anti-apoptotic activity. Recently, it was found to induce autophagy in various tissues as well...
2018: International Journal of Biological Sciences
Qiang Zhang, Yiping Weng, Yuqing Jiang, Shujie Zhao, Dong Zhou, Nanwei Xu
Toll-like receptor 4 (TLR4) families are receptors for ligands that initiate extracellular or intracellular signaling, such as lipopolysaccharides (LPS). It has been reported that TLR4 activation resulted in the upregulation of a coordinated set of proinflammatory mediators and inhibition of matrix expression in the intervertebral disc (IVD). miR-140-5p (miR-140) is reported to participate in cellular anti-inflammatory processes and target TLR4. In the present study, we investigated the relationship between TLR4 and miR-140 in IVD degeneration...
June 12, 2018: Oncology Reports
Zhigang Qu, Zhe Quan, Qi Zhang, Zhenyu Wang, Qingxu Song, Xinming Zhuang, Changfeng Fu, Feng Xu, Yadong Liu, Yuanyi Wang, Zheng Wang, Yi Liu
The present study aimed to identify novel intervertebral disc degeneration (IDD)‑associated long noncoding (lnc)RNAs and genes. The lncRNA and mRNA microarray dataset GSE56081 was downloaded from the Gene Expression Omnibus database and included 5 samples from patients with degenerative lumbar nucleus pulposus and 5 normal controls. Differentially expressed lncRNAs or differentially expressed genes (DEGs) were identified and co‑expression network analysis was performed followed by functional analysis for genes in the network...
June 5, 2018: Molecular Medicine Reports
Frances C Bach, Anna R Tellegen, Martijn Beukers, Alberto Miranda-Bedate, Michelle Teunissen, Willem A M de Jong, Stefan A H de Vries, Laura B Creemers, Karin Benz, Björn P Meij, Keita Ito, Marianna A Tryfonidou
The socioeconomic burden of chronic back pain related to intervertebral disc (IVD) disease is high and current treatments are only symptomatic. Minimally invasive strategies that promote biological IVD repair should address this unmet need. Notochordal cells (NCs) are replaced by chondrocyte-like cells (CLCs) during IVD maturation and degeneration. The regenerative potential of NC-secreted substances on CLCs and mesenchymal stromal cells (MSCs) has already been demonstrated. However, identification of these substances remains elusive...
May 29, 2018: Oncotarget
Xiaoming Sheng, Qingsong Guo, Junbo Yu, Youjia Xu
Intervertebral disc degeneration is associated with angiogenesis and is the primary cause of disc-associated disease. Several studies have indicated the importance of microRNA (miR)-21 in angiogenesis. Thus, the present study aimed to validate the role and underlying mechanisms of miR-21 in a rat model of intervertebral disc degeneration. A total of 60 specific-pathogen-free Sprague-Dawley rats were used for in vivo experiments. A rat model of intervertebral disc degeneration was established and miR-21 inhibitor (antagomiR-21) was administered...
July 2018: Experimental and Therapeutic Medicine
Tristan Maerz, Michael Newton, Abigail A Marek, Michael Planalp, Kevin Baker
BACKGROUND/CONTEXT: Degenerative disc disease (DDD) is associated with longitudinal remodeling of paravertebral tissues. While chronic vertebral changes in advanced stages of DDD are well-studied, very little data exists on acute vertebral bone remodeling at the onset and progression of DDD. PURPOSE: To longitudinally characterize bony remodeling in a rodent model of disc injury-induced DDD. STUDY DESIGN/SETTING: In vivo animal study involving a rat annulus fibrosus injury model of DDD...
June 7, 2018: Spine Journal: Official Journal of the North American Spine Society
Min-Woo Kim, Kyu Yeol Lee, Seunghyun Lee
STUDY DESIGN: A retrospective cohort study. PURPOSE: To investigate the factors affecting symptoms in young adults with L5 spondylolysis. OVERVIEW OF LITERATURE: L5 spondylolysis is a common disease. However, not all patients diagnosed with L5 spondylolysis exhibit symptoms. This study examined the factors associated with the symptoms of young adults with L5 spondylolysis. METHODS: The medical records of 70 young adults (mean age, 31...
June 2018: Asian Spine Journal
Xu Wei, Li Gengwu, Chen Chao, Li Yifan, Sang Shang, Hu Ruixi, Ji Yunhan, Zhu Xiaodong, Li Zhikun
BACKGROUND: Studies have shown that lumbar disc herniation, degenerative lumbar instability, and other degenerative lumbar spinal diseases are often secondary to disc degeneration. By studying the intervertebral disc, researchers have clarified the pathological changes involved in intervertebral disc degeneration but have ignored the roles of biomechanical factors in the development of disc degeneration. This study aims to investigate the relationships among the location, scope, and extent of lumbar disc degeneration and sagittal spinal-pelvic parameters...
June 4, 2018: Journal of Orthopaedic Surgery and Research
Patrick Strube, Matthias Pumberger, Lena Sonnow, Timo Zippelius, Dimitri Nowack, Robert K Zahn, Michael Putzier
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: The objective was to prove the association between anatomic pelvis parameters and specific types of lumbar spinal degeneration. SUMMARY OF BACKGROUND DATA: Different spinopelvic sagittal profile types are suggested to be associated with specific degenerative lumbar spine pathologies. Because pelvic morphology plays a key role defining the spinal shape as well as its load and function it thereby potentially predisposes the development of spinal degeneration...
May 31, 2018: Clinical Spine Surgery
Tao Wu, Hai Nie, Allan B Dietz, David R Salek, Jay Smith, Andre J van Wijnen, Wenchun Qu
BACKGROUND: Transplantation of mesenchymal stem cells (MSCs) is a promising therapy for degenerative spine conditions. However, cell therapy for painful spine degeneration presently requires use of contrast agents during fluoroscopy-guided injections and the effects of these agents on MSCs represents a gap in knowledge. OBJECTIVE: To investigate the biological effects of contrast media that are co-injected with MSCs. DESIGN: Prospective observational study...
May 31, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
D M Varma, H A Lin, R G Long, G T Gold, A C Hecht, J C Iatridis, S B Nicoll
Back and neck pain are commonly associated with intervertebral disc (IVD) degeneration. Structural augmentation of diseased nucleus pulposus (NP) tissue with biomaterials could restore degeneration-related IVD height loss and degraded biomechanical behaviors; however, effective NP replacement biomaterials are not commercially available. This study developed a novel, crosslinked, dual-polymer network (DPN) hydrogel comprised of methacrylated carboxymethylcellulose (CMC) and methylcellulose (MC), and used in vitro, in situ and in vivo testing to assess its efficacy as an injectable, in situ gelling, biocompatible material that matches native NP properties and restores IVD biomechanical behaviors...
May 30, 2018: European Cells & Materials
Marc A Stadelmann, Ghislain Maquer, Benjamin Voumard, Aaron Grant, David B Hackney, Peter Vermathen, Ron N Alkalay, Philippe K Zysset
Intervertebral disc degeneration is a common disease that is often related to impaired mechanical function, herniations and chronic back pain. The degenerative process induces alterations of the disc's shape, composition and structure that can be visualized in vivo using magnetic resonance imaging (MRI). Numerical tools such as finite element analysis (FEA) have the potential to relate MRI-based information to the altered mechanical behavior of the disc. However, in terms of geometry, composition and fiber architecture, current FE models rely on observations made on healthy discs and might therefore not be well suited to study the degeneration process...
May 17, 2018: Journal of the Mechanical Behavior of Biomedical Materials
Huzhe Liu, Jieliang Shen, Hao Zhou, Shengxi Xu, Zhenming Hu
Objective: To investigate the regulatory effect of resveratrol (RES) on the extracellular matrix (ECM) expression of nucleus pulposus cells (NPC), and its relative molecular mechanism. Methods: Ten patients receiving discectomy were collected, of which 5 patients were young with spinal burst fracture, classified as control group; the rest 5 patients were senile with lumbar disc herniation, classified as degenerative group. The nucleus pulposus tissue of 2 groups were collected, the in situ expression of β-catenin was detected by immunohistochemistry, and the protein expressions of collagen type Ⅱ and Aggrecan were detected by Western blot...
April 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
Tian Wang, Matthew H Pelletier, Chris Christou, Rema Oliver, Ralph J Mobbs, William R Walsh
BACKGROUND CONTEXT: Degenerative disc disease (DDD) is a common, widespread socio-economic problem. Appropriate large animal models of DDD are required for improved understanding and to serve as pre-clinical test beds for therapeutic strategies PURPOSE: Evaluate the effects of short and medium duration immobilization on the sheep lumbar intervertebral disc and facet joints, to establish a large animal model for DDD research. STUDY DESIGN: An in vivo sheep model evaluating the effect of short and medium term immobilization on disc degeneration...
May 22, 2018: Spine Journal: Official Journal of the North American Spine Society
Zong-Chao Liu, Zhen-Long Wang, Chen-Yi Huang, Zhi-Jiang Fu, Yong Liu, Zhang-Chao Wei, Shi-Gui Liu, Chuan Ma, Jie-Liang Shen, Dayue Darrel Duan
Lower back pain (LBP) is the most common disease in orthopedic clinics world-wide. A classic fangji of traditional Chinese medicine, duhuo jisheng decoction (DHJSD), has been proven clinically effective for LBP but its therapeutic mechanisms remain unclear. We hypothesized that DHJSD might relieve LBP through inhibiting the exaggerated proinflammatory cytokines and extracellular matrix (ECM) degradation. Thus, we studied the effects of DHJSD on stromal cell-derived factor-1 (SDF-1)-induced inflammation and ECM degradation in human nucleus pulposus cells (hNPCs)...
May 24, 2018: Acta Pharmacologica Sinica
Shinya Okuda, Yukitaka Nagamoto, Tomiya Matsumoto, Tsuyoshi Sugiura, Yoshifumi Takahashi, Motoki Iwasaki
STUDY DESIGN: A retrospective study. OBJECTIVE: To investigate the incidence of adjacent segment disease (ASD) at 2, 5, and 10 years after primary posterior lumbar interbody fusion (PLIF), and clinical features of ASD. SUMMARY OF BACKGROUND DATA: Few reports have examined ASD after PLIF with more than 10 years follow-up. Furthermore, no reports have examined limited conditions of preoperative pathology, fusion segment, and fusion method with long follow-up...
May 22, 2018: Spine
Koichiro Murata, Koji Akeda, Norihiko Takegami, Kevin Cheng, Koichi Masuda, Akihiro Sudo
BACKGROUND: The progression of intervertebral disc (IVD) degeneration leads to rupture within IVD tissues. The location and appearance of areas of gaseous radiolucency in the IVD, known as vacuum phenomena (VPs), are considered to indirectly indicate the position and extent of IVD rupture. The clinical significance of VPs in degenerated IVDs is not fully understood. The purpose of this study is to assess and classify the morphology of IVD ruptures by the presence of intradiscal VPs, and to examine the association between morphological VP-positive IVD ruptures and degenerative lumbar diseases...
May 24, 2018: BMC Musculoskeletal Disorders
Anastasios Kouroumalis, Eleni Mavrogonatou, Olga D Savvidou, Panayiotis J Papagelopoulos, Harris Pratsinis, Dimitris Kletsas
Intervertebral discs (IVDs) are the joints of the spine, mainly consisting of extracellular matrix (ECM) with a low number of cells embedded therein. Low cellularity stems from nutrient deprivation due to the lack of blood supply, as well as from the hypoxic and hyperosmotic conditions prevailing in the tissue. Intervertebral disc degeneration (IDD) has been firmly connected with low back pain, a major age-related disease, whereas degenerated discs have been characterized by increased proteolytic activity and accumulation of senescent cells...
May 17, 2018: Mechanisms of Ageing and Development
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