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Degenerated Disc Disease

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https://www.readbyqxmd.com/read/28431805/lumbar-disc-degeneration-progression-in-young-women-in-their-20-s-a-prospective-ten-year-follow-up
#1
Hiroto Makino, Yoshiharu Kawaguchi, Shoji Seki, Masato Nakano, Taketoshi Yasuda, Kayo Suzuki, Shiro Ikegawa, Tomoatsu Kimura
BACKGROUND: Lumbar disc degeneration (LDD) is known to be the main cause of low back pain, although it is unclear how or when LDD progresses. The purpose of this study was to clarify the process and features of LDD progression in young women. METHODS: We enrolled 480 nursing students and carried out a prospective cohort study in 84 nursing students. MRI of the lumbar spine was taken once during their time as a student and again at 9.8 years (7-14) after the first MRI when they were working as nurses...
April 18, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28422837/multilevel-cervical-disc-replacement-versus-multilevel-anterior-discectomy-and-fusion-a-meta-analysis
#2
Ting-Kui Wu, Bei-Yu Wang, Yang Meng, Chen Ding, Yi Yang, Ji-Gang Lou, Hao Liu
BACKGROUND: Cervical disc replacement (CDR) has been developed as an alternative surgical procedure to anterior cervical discectomy and fusion (ACDF) for the treatment of single-level cervical degenerative disc disease. However, patients with multilevel cervical degenerative disc disease (MCDDD) are common in our clinic. Multilevel CDR is less established compared with multilevel ACDF. This study aims to compare the outcomes and evaluate safety and efficacy of CDR versus ACDF for the treatment of MCDDD...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28403037/characteristics-of-submacular-hemorrhages-in-age-related-macular-degeneration
#3
Jae Hui Kim, Young Suk Chang, Jong Woo Kim, Chul Gu Kim
PURPOSE: The aims of this research are to report the incidence and characteristics of submacular hemorrhage secondary to neovascular age-related macular degeneration (AMD) and to compare the detailed morphologic features of hemorrhages between typical neovascular AMD and polypoidal choroidal vasculopathy (PCV). METHODS: This retrospective observational study included 791 eyes of 791 patients who had newly diagnosed neovascular AMD at a single institution. The incidence and extent of submacular hemorrhage of one disc area or greater were estimated and compared between typical neovascular AMD and PCV...
May 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28401158/histological-identification-of-propionibacterium-acnes-in-nonpyogenic-degenerated-intervertebral-discs
#4
Ye Yuan, Zezhu Zhou, Yucheng Jiao, Changwei Li, Yuehuan Zheng, Yazhou Lin, Jiaqi Xiao, Zhe Chen, Peng Cao
Purpose. Low-virulence anaerobic bacteria, especially the Propionibacterium acnes (P. acnes), have been thought to be a new pathogeny for a series of disc diseases. However, until now, there has been no histological evidence to confirm this link. The purpose of this study was to confirm the presence of P. acnes in nonpyogenic intervertebral discs via histological observation. Method. Degenerated intervertebral discs were harvested from 76 patients with low back pain and/or sciatica but without any symptoms of discitis or spondylodiscitis...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28392965/mechanosignaling-activation-of-tgf%C3%AE-maintains-intervertebral-disc-homeostasis
#5
Qin Bian, Lei Ma, Amit Jain, Janet L Crane, Khaled Kebaish, Mei Wan, Zhengdong Zhang, X Edward Guo, Paul D Sponseller, Cheryle A Séguin, Lee H Riley, Yongjun Wang, Xu Cao
Intervertebral disc (IVD) degeneration is the leading cause of disability with no disease-modifying treatment. IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal (NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin αvβ6-mediated activation of transforming growth factor beta (TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease (DDD)...
2017: Bone Research
https://www.readbyqxmd.com/read/28377243/hybrid-bone-spect-ct-imaging-in-evaluation-of-chronic-low-back-pain-correlation-with-modic-changes-and-degenerative-disc-disease
#6
Vittorio M Russo, Ranju T Dhawan, Nishanth Dharmarajah, I Baudracco, Antonio I Lazzarino, Adrian T Casey
BACKGROUND CONTEXT: Multiple radiological modalities are used in the evaluation of patients with low back pain (LBP). Only limited evidence currently exists to support the use of Bone HDP (hydroxydiphosphonate) SPECT/CT (Single Photon Emission Computed Tomography) in patients with Modic changes (MC) and degenerative disc disease (DDD). PURPOSE: The aim of this study was to assess the value of the hybrid Bone SPECT/CT imaging in patients with chronic low back pain...
April 1, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28358123/molecular-therapy-for-degenerative-disc-disease-clues-from-secretome-analysis-of-the-notochordal-cell-rich-nucleus-pulposus
#7
Ajay Matta, M Zia Karim, David E Isenman, W Mark Erwin
Degenerative disc disease (DDD) is associated with spinal pain often leading to long-term disability. However, the non-chondrodystrophic canine intervertebral disc is protected from the development of DDD, ostensibly due to its retention of notochordal cells (NC) in the nucleus pulposus (NP). In this study, we hypothesized that secretome analysis of the NC-rich NP will lead to the identification of key proteins that delay the onset of DDD. Using mass-spectrometry, we identified 303 proteins including components of TGFβ- and Wnt-signaling, anti-angiogeneic factors and proteins that inhibit axonal ingrowth in the bioactive fractions of serum free, notochordal cell derived conditioned medium (NCCM)...
March 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28355743/-topping-off-surgery-versus-double-segment-fusion-for-treatment-of-lumbar-degenerative-disease-with-mid-long-term-follow-up
#8
X L Chen, Y Hai, L Guan, Y Z Liu, J C Yang, Q J Su, N Kang, X L Meng, L Yang, Y Wang
Objective: To compare the mid-long term clinical effect of Topping-off surgery and lumbar fusion surgery for two-segmental lumbar degenerative disease. Methods: From March 2009 to March 2012, one hundred and twenty-six consecutive patients (Topping-off surgery and two-segment PLIF surgery) were studied in Orthopedics Department, Beijing Chao-Yang Hospital, Capital Medical University.The VAS and ODI were used to assess clinical symptoms.All patients underwent flexion/extension radiographs examinations before surgery, 1, 2 years and last follow-up postoperatively...
March 21, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28351496/a-new-in-vivo-method-to-retard-progression-of-intervertebral-disc-degeneration-through-stimulation-of-endogenous-stem-cells-with-simvastatin
#9
Zenan Huang, Liang Zhang, Xinmin Feng, Tao Chen, Songchao Bi
Degenerative disc disease is a worldwide problem, however, conservative treatment and surgical treatment can only partly relieve symptoms, but do not have therapeutic effect on the degenerated intervertebral disc (IVD) itself. The use of stem cell transplantation has become one of the most popular treatments. With gradually understanding of the endogenous mechanism of stem cells migration and movement in vivo, endogenous IVD stem cells can be activated to repair and reconstruct the degenerated IVD. Nucleus pulposus mensenchymal stem cells exhibit more potent biological activity in the hypoxic environment of the IVD...
April 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28343922/correlation-of-matrix-metalloproteinase-mmp-1-2-3-and-9-expressions-with-demographic-and-radiological-features-in-primary-lumbar-intervertebral-disc-disease
#10
Recep Basaran, Mehmet Senol, Seyma Ozkanli, Mustafa Efendioglu, Tuncay Kaner
Degeneration of IVD is a progressive and irreversible process and can be evaluated with immunohistochemical examination or radiological grading. MMPs are a family of proteolytic enzymes and involved in the degradation of the matrix components of the IVD. We aimed to compare MMP-1, -2, -3, and -9 expressions with demographic features, visual analogue scale (VAS), Oswestry Disability Index (ODI) and radiological (MRI) grades. The study involved 60 participants. We recorded data about age, complaint, radiological imaging, expression levels of MMP-1, -2, -3, and -9, ODI and VAS for back pain retrospectively...
March 23, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28343048/protective-effect-of-cddo-ea-against-high-glucose-induced-oxidative-injury-via-the-nrf2-ho-1-pathway
#11
Cun-Xin Zhang, Ting Wang, Jin-Feng Ma, Yang Liu, Zheng-Gang Zhou, De-Chun Wang
BACKGROUND CONTEXT: Intervertebral disc degeneration (IDD) is the main cause of low back pain, and nucleus pulposus (NP) cell apoptosis is an important risk factor of IDD. However, the molecular mechanism of this disease remains unknown. PURPOSE: To assess the potential protective effect of CDDO-ethyl amide (EA) against high-glucose-induced oxidative stress injury in NP cells and to investigate the mechanism of antioxidative effects and apoptotic inhibition. STUDY DESIGN/SETTING: To find new molecule to inhibit intervertebral disc degeneration...
March 22, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28340364/cervical-facet-force-analysis-after-disc-replacement-versus-fusion
#12
Vikas V Patel, Zachary R Wuthrich, Kirk C McGilvray, Matthew C Lafleur, Emily M Lindley, Derrick Sun, Christian M Puttlitz
BACKGROUND: Cervical total disc replacement was developed to preserve motion and reduce adjacent-level degeneration relative to fusion, yet concerns remain that total disc replacement will lead to altered facet joint loading and long-term facet joint arthrosis. This study is intended to evaluate changes in facet contact force, pressure and surface area at the treated and superior adjacent levels before and after discectomy, disc replacement, and fusion. METHODS: Ten fresh-frozen human cadaveric cervical spines were potted from C2 to C7 with pressure sensors placed into the facet joints of C3-C4 and C4-C5 via slits in the facet capsules...
March 18, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28338454/impact-of-preoperative-diagnosis-on-patient-satisfaction-following-lumbar-spine-surgery
#13
Charles H Crawford, Leah Y Carreon, Mohamad Bydon, Anthony L Asher, Steven D Glassman
OBJECTIVE Patient satisfaction is a commonly used metric in the current health care environment. While factors that affect patient satisfaction following spine surgery are complex, the authors of this study hypothesized that specific diagnostic groups of patients are more likely to be satisfied after spine surgery and that this is reflected in patient-reported outcome measures. The purpose of this study was to determine if the preoperative diagnosis-disc herniation, stenosis, spondylolisthesis, adjacent segment degeneration, or mechanical disc collapse-would impact patient satisfaction following surgery...
March 24, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28321567/adjacent-segment-pathology-natural-history-or-effect-of-anterior-cervical-discectomy-and-fusion-a-10-year-follow-up-radiological-multicenter-study-using-an-evaluation-scale-of-the-ageing-spine
#14
Alessandro Pesce, Venceslao Wierzbicki, Emanuele Piccione, Alessandro Frati, Antonino Raco, Riccardo Caruso
PURPOSE: Aim of this study is to compare late degenerative MRI changes in a subset of patients operated on with ACDF to a second subset of patients presenting indication to ACDF but never operated on. METHODS: Patients from both subgroups received surgical indication according to the same criteria. Both subgroups underwent a cervical spine MRI in 2004-2005 and 10 years later in 2015. These MRI scans were retrospectively evaluated with a cervical spine ageing scale...
March 20, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28321409/could-the-topping-off-technique-be-the-preventive-strategy-against-adjacent-segment-disease-after-pedicle-screw-based-fusion-in-lumbar-degenerative-diseases-a-systematic-review
#15
REVIEW
Po-Hsin Chou, Hsi-Hsien Lin, Howard S An, Kang-Ying Liu, Wei-Ren Su, Cheng-Li Lin
The "topping-off" technique is a new concept applying dynamic or less rigid fixation such as hybrid stabilization device (HSD) or interspinous process device (IPD) for the purpose of avoiding adjacent segment disease (ASD) proximal to the fusion construct. A systematic review of the literature was performed on the effect of topping-off techniques to prevent or decrease the occurrence of ASD after lumbar fusion surgery. We searched through major online databases, PubMed and MEDLINE, using key words related to "topping-off" technique...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28303068/high-dose-intravenous-pulse-steroid-therapy-for-optic-disc-swelling-and-subretinal-fluid-in-non-arteritic-anterior-ischemic-optic-neuropathy
#16
Kei Takayama, Hiroki Kaneko, Shu Kachi, Eimei Ra, Yasuki Ito, Hiroko Terasaki
Non-arteritic anterior ischemic optic neuropathy (NAION) is a disease with microvascular abnormality that causes acute optic disc swelling (ODS) and, in severe cases, subretinal fluid (SRF) accumulation. ODS causes compartment syndrome and subsequent axonal degeneration and loss of retinal ganglion cells by apoptosis. No treatment modalities have been effective, although some cases improved after the intake of oral systemic steroids. We reported a case of a 72-year-old man who was referred due to a visual defect in the right eye...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28288396/adjacent-segment-disease-after-instrumented-fusion-for-adult-lumbar-spondylolisthesis-incidence-and-risk-factors
#17
Zhao-Ming Zhong, Vedat Deviren, Bobby Tay, Shane Burch, Sigurd H Berven
OBJECTIVE: A potential long-term complication of lumbar fusion is the development of adjacent segment disease (ASD), which may necessitate second surgery and adversely affect outcomes. The objective of this is to determine the incidence of ASD following instrumented fusion in adult patients with lumbar spondylolisthesis and to identify the risk factors for this complication. PATIENTS AND METHODS: We retrospectively assessed adult patients who had undergone decompression and instrumented fusion for lumbar spondylolisthesis between January 2006 and December 2012...
February 27, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28266560/3d-characterization-of-morphological-changes-in-the-intervertebral-disc-and-endplate-during-aging-a-propagation-phase-contrast-synchrotron-micro-tomography-study
#18
Yong Cao, Shenghui Liao, Hao Zeng, Shuangfei Ni, Francis Tintani, Yongqiang Hao, Lei Wang, Tianding Wu, Hongbin Lu, Chunyue Duan, Jianzhong Hu
A better understanding of functional changes in the intervertebral disc (IVD) and interaction with endplate is essential to elucidate the pathogenesis of IVD degeneration disease (IDDD). To date, the simultaneous depiction of 3D micro-architectural changes of endplate with aging and interaction with IVD remains a technical challenge. We aim to characterize the 3D morphology changes of endplate and IVD during aging using PPCST. The lumbar vertebral level 4/5 IVDs harvested from 15-day-, 4- and 24-month-old mice were initially evaluated by PPCST with histological sections subsequently analyzed to confirm the imaging efficiency...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28262396/a-new-zero-profile-stand-alone-fidji-cervical-cage-for-the-treatment-of-the-single-and-multilevel-cervical-degenerative-disc-disease
#19
Zhonghai Li, Huadong Wang, Li Li, Jiaguang Tang, Dongfeng Ren, Shuxun Hou
To investigate the clinical and radiological results of the new zero-profile, stand-alone Fidji cervical cage to treat single- and multiple-level cervical DDD, and evaluate the safety and efficiency. Between October 2011 and July 2014, 72 consecutive patients (41 males and 31 females; mean age 50.9years [range, 33-68years]) with cervical DDD who underwent surgery and were followed for more than 2years were enrolled in this study (mean 31.1months, range 24-47months). The study compared clinical outcomes, radiologic parameters and complication rates...
March 2, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28259005/removal-of-fixation-construct-could-mitigate-adjacent-segment-stress-after-lumbosacral-fusion-a-finite-element-analysis
#20
Yueh-Ying Hsieh, Chia-Hsien Chen, Fon-Yih Tsuang, Lien-Chen Wu, Shang-Chih Lin, Chang-Jung Chiang
BACKGROUND DATA: Combined usage of posterior lumbar interbody fusion and transpedicular fixation has been extensively used to treat the various lumbar degenerative disc diseases. The transpedicular fixator aims to increase stability and enhance the fusion rate. However, how the fused disc and bridged vertebrae respectively affect adjacent-segment diseases progression is not yet clear. METHODS: Using a validated lumbosacral finite-element model, three variations at the L4-L5 segment were analyzed: 1) moderate disc degeneration, 2) instrumented with a stand-alone cage and pedicle screw fixators, and 3) with the cage only after fusion...
February 23, 2017: Clinical Biomechanics
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