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Degenerated Disc Disease

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https://www.readbyqxmd.com/read/29436660/cartilage-intermediate-layer-protein-is-regulated-by-mechanical-stress-and-affects-extracellular-matrix-synthesis
#1
Jinyue He, Chencheng Feng, Jing Sun, Kang Lu, Tongwei Chu, Yue Zhou, Yong Pan
Lumbar disc disease (LDD) is common in aged populations, and it is primarily caused by intervertebral disc degeneration (IDD). Cartilage intermediate layer protein (CILP), which is specifically expressed in intervertebral discs (IVDs), is suspected to be associated with IDD. However, it remains unclear whether CILP contributes to IDD in humans. Furthermore, the regulation of CILP in human IVDs is poorly understood, especially by mechanical stimuli, which are regarded as primary factors promoting IDD. To address these issues, the present study collected nucleus pulposus (NP) cells from patients undergoing lumbar spinal surgery for degenerative disc disease (DDD)...
February 12, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29436582/transplantation-of-allogenic-nucleus-pulposus-cells-attenuates-intervertebral-disc-degeneration-by-inhibiting-apoptosis-and-increasing-migration
#2
Weiheng Wang, Guoying Deng, Yuanyuan Qiu, Xiaodong Huang, Yanhai Xi, Jiangming Yu, Xiangqun Yang, Xiaojian Ye
Transplantation of nucleus pulposus cells (NPCs) into the intervertebral disc (IVD) has been demonstrated to be an effective treatment of degenerative disc disease (DDD). However, the underlying mechanisms have remained to be sufficiently elucidated. The aim of the present study was to explore the potential cell migration and anti‑apoptosis efficacy of NPCs in the treatment of DDD. NPCs cultured from rats expressing green fluorescent protein (GFP‑NPCs) were transplanted into the degenerated IVD, and the migration of GFP‑NPCs, as well as the degeneration and apoptosis of the IVD were detected to evaluate the therapeutic effect in vivo...
February 2, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29417772/-case-control-study-on-two-different-surgical-approaches-combined-fixation-with-lumbar-interbody-fusion-for-the-treatment-of-single-segmental-lumbar-vertebra-diseases
#3
Zhong-You Zeng, Wei-Feng Yan, Yong-Xing Song, Ke-Ya Mao, Jian-Fei Ji, Jian-Qiao Zhang, Peng Wu, Fei Pei, Guo-Hao Song, Jian-Fu Han, Wei Yu
OBJECTIVE: To discuss the advantages and disadvantages of two different surgical approaches combined fixation with lumbar interbody fusion in treating single segmental lumbar vertebra diseases. METHODS: The clinical data of 86 patients with single segmental lumbar vertebra diseases treated from June 2011 to June 2013 was retrospectively analyzed. There were 33 males and 53 females, aged from 28 to 76 years old with an average of 53.0 years. Among them, there were 39 cases of lumbar disc degeneration, 22 cases of lumbar disc herniation complicated with spinal canal stenosis, 9 cases of huge lumbar disc herniation and 16 cases of lumbar degenerative spondylolisthesis (Meyerding degree I )...
May 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29416763/dysregulation-of-yap-by-the-hippo-pathway-is-involved-in-intervertebral-disc-degeneration-cell-contact-inhibition-and-cell-senescence
#4
Cong Zhang, Feng Wang, Zhiyang Xie, Lu Chen, Arjun Sinkemani, Haomin Yu, Kun Wang, Lu Mao, Xiaotao Wu
The Hippo pathway plays important roles in wound healing, tissue repair and regeneration, and in the treatment of degenerative diseases, by regulating cell proliferation and apoptosis in mammals. Intervertebral disc degeneration (IDD) is one of the major causes of low back pain, a widespread issue associated with a heavy economic burden. However, the mechanism underlying how the Hippo pathway regulates IDD is not well understood. Here, we demonstrate that the Hippo pathway is involved in natural IDD. Activation and dephosphorylation of yes-associated protein (YAP) were observed in younger rat discs, and decreased gradually with age...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29415913/hybrid-method-of-transvertebral-foraminotomy-combined-with-anterior-cervical-decompression-and-fusion-for-multilevel-cervical-disease
#5
Yu Yamamoto, Masahito Hara, Yusuke Nishimura, Shoichi Haimoto, Toshihiko Wakabayashi
Transvertebral foraminotomy (TVF) combined with anterior cervical decompression and fusion (ACDF) can be used to treat multilevel cervical spondylotic myelopathy and radiculopathy; however, the radiological outcomes and effectiveness of this hybrid procedure are unknown. We retrospectively assessed 22 consecutive patients treated with combined TVF and ACDF between January 2007 and May 2016. The Japanese Orthopedic Association (JOA) score and Odom's criteria were analyzed. Radiological assessment included the C2-7 sagittal Cobb angle (CA) and range of motion (ROM)...
February 7, 2018: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/29412188/do-findings-identified-on-magnetic-resonance-imaging-predict-future-neck-pain-a-systematic-review
#6
REVIEW
Laura Hill, David Aboud, James Elliott, John Magnussen, Michele Sterling, Daniel Steffens, Mark Hancock
BACKGROUND CONTEXT: Magnetic resonance imaging (MRI) has the potential to identify pathology contributing to neck pain. However, the importance of findings on MRI remains unclear. PURPOSE: To investigate whether findings on cervical spine MRI predict future neck pain. STUDY DESIGN: Systematic review. PATIENT SAMPLE: People with or without neck pain. OUTCOME MEASURES: Clinically important neck pain outcomes such as pain and disability...
February 2, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29408574/clinical-and-radiological-features-of-three-reconstructive-procedures-for-the-surgical-management-of-patients-with-bi-level-cervical-degenerative-disc-disease-at-a-minimum-follow-up-period-of-five-years-a-comparative-study
#7
Kai-Feng Wang, Shuo Duan, Zhen-Qi Zhu, Hai-Ying Liu, Chen-Jun Liu, Shuai Xu
OBJECTIVE: To assess the mid-long-term follow-up of the safety and efficacy of anterior cervical discectomy and fusion (ACDF), cervical artificial disc replacement (CADR) and hybrid surgery (HS) for bi-level cervical degenerative disc disease (cDDD). METHODS: 77 patients who underwent ACDF, HS and CADR were retrospectively reviewed. Clinical effects were evaluated based on NDI, VAS and JOA scores, and the Odom criteria. Radiographic outcomes were evaluated, including cervical range of motion(ROM), operative and adjacent segments ROM, incidence of adjacent segments degeneration(ASD) and heterotopic ossification(HO)...
January 30, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29396379/therapeutic-effects-of-gefitinib-encapsulated-thermosensitive-injectable-hydrogel-in-intervertebral-disc-degeneration
#8
Zongyou Pan, Heng Sun, Binbin Xie, Dongdong Xia, Xiaoan Zhang, Dongsheng Yu, Jun Li, Yuzi Xu, Zuhua Wang, Yan Wu, Xiaolei Zhang, Yafei Wang, Qianbao Fu, Wei Hu, Yang Yang, Varitsara Bunpetch, Weiliang Shen, Boon Chin Heng, Shufang Zhang, Hongwei Ouyang
Intervertebral disc (IVD) degeneration is one of the most widespread musculoskeletal diseases worldwide, which remains an intractable clinical challenge. The aim of this study is to investigate the therapeutic potential of the small molecule gefitinib (an epidermal growth factor receptor (EGFR) inhibitor) in ameliorating IVD degeneration. Aberrant EGFR activation levels were detected in both human and rat degenerative IVDs, which prompted us to investigate the functional roles of EGFR by utilizing inducible cartilage-specific EGFR-deficient mice...
April 2018: Biomaterials
https://www.readbyqxmd.com/read/29394936/risk-factors-for-non-fusion-segment-disease-after-anterior-cervical-spondylosis-surgery-a-retrospective-study-with-long-term-follow-up-of-171-patients
#9
Ziqiang Wang, Liangliang Zhou, Bin Lin, Keran Song, Qinghe Niu, Dongfeng Ren, Jiaguang Tang
BACKGROUND: The purpose of this study was to investigate the incidence and causes of non-fusion segment disease (NFSD), both adjacent and non-adjacent to a fused segment, after anterior cervical arthrodesis. METHODS: This is a single-center study. Between January 1998 and January 2011, two surgeons' 171 patients who had an anterior cervical decompression and fusion were followed clinically for more than 5 years. The correlation between the incidence of symptomatic non-fusion segment disease and the following clinical parameters (age at operation, fusion levels,) and radiological parameters (number of patients who had a plate, anterior cervical decompression and fusion (ACDF) or corpectomies, preoperative and postoperative cervical spine alignment, Pavlov's ratio at the C5 level, and preoperative existence of a non-fusion segment degeneration on magnetic resonance imaging) was evaluated...
February 2, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29390547/quantitative-evaluation-of-lumbar-intervertebral-disc-degeneration-by-axial-t2-mapping
#10
Leitao Huang, Yuan Liu, Yi Ding, Xia Wu, Ning Zhang, Qi Lai, Xianjun Zeng, Zongmiao Wan, Min Dai, Bin Zhang
To quantitatively evaluate the clinical value and demonstrate the potential benefits of biochemical axial T2* mapping-based grading of early stages of degenerative disc disease (DDD) using 3.0-T magnetic resonance imaging (MRI) in a clinical setting.Fifty patients with low back pain and 20 healthy volunteers (control) underwent standard MRI protocols including axial T2* mapping. All the intervertebral discs (IVDs) were classified morphologically. Lumbar IVDs were graded using Pfirrmann score (I to IV). The T2* values of the anterior annulus fibrosus (AF), posterior AF, and nucleus pulposus (NP) of each lumbar IVD were measured...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29384883/comparison-of-the-clinical-effects-of-zero-profile-anchored-spacer-roi-c-and-conventional-cage-plate-construct-for-the-treatment-of-noncontiguous-bilevel-of-cervical-degenerative-disc-disease-cddd-a-minimum-2-year-follow-up
#11
Yingjie Lu, Weiguo Bao, Zongyi Wang, Feng Zhou, Jun Zou, Weimin Jiang, Huilin Yang, Zhiming Zhang, Xuesong Zhu
Comparing the clinical and radiographic outcomes in anterior cervical discectomy and fusion (ACDF) using a zero-profile anchored spacer (ROI-C) or a conventional cage-plate construct (CPC) for treating noncontiguous bilevel of cervical degenerative disc disease (CDDD).Overall, 46 patients with 2 noncontiguous segments of CDDD, treated with ACDF from January 2011 to October 2015, were included in this study. ROI-C was used in 22 patients (group A) and CPC in 24 patients (group B). The clinical and radiographic outcomes and complications were compared pre- and postoperatively...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29381716/quantitative-mri-in-early-intervertebral-disc-degeneration-t1rho-correlates-better-than-t2-and-adc-with-biomechanics-histology-and-matrix-content
#12
Cornelis P L Paul, Theodoor H Smit, Magda de Graaf, Roderick M Holewijn, Arno Bisschop, Peter M van de Ven, Margriet G Mullender, Marco N Helder, Gustav J Strijkers
INTRODUCTION: Low-back pain (LBP) has been correlated to the presence of intervertebral disc (IVD) degeneration on T2-weighted (T2w) MRI. It remains challenging, however, to accurately stage degenerative disc disease (DDD) based on T2w MRI and measurements of IVD height, particularly for early DDD. Several quantitative MRI techniques have been introduced to detect changes in matrix composition signifying early DDD. In this study, we correlated quantitative T2, T1rho and Apparent Diffusion Coefficient (ADC) values to disc mechanical behavior and gold standard early DDD markers in a graded degenerated lumbar IVD caprine model, to assess their potential for early DDD detection...
2018: PloS One
https://www.readbyqxmd.com/read/29378457/review-of-long-term-outcomes-of-disc-arthroplasty-for-symptomatic-single-level-cervical-degenerative-disc-disease
#13
Siddharth A Badve, Pierce D Nunley, Swamy Kurra, William F Lavelle
Cervical disc arthroplasty (CDA) was developed as an alternative for anterior cervical discectomy and fusion (ACDF) for nerve root decompression. The rationale behind CDA was to help prevent adjacent segment degeneration which potentially may lead to additional surgery. Multiple randomized controlled trials have evaluated a myriad of disc arthroplasty devices over the past 10 years and provided data regarding clinical benefits and safety. Their long-term data, reporting results at 5-10 years, presents the opportunity to comment on the overall efficacy, safety and reported complications of these devices...
January 30, 2018: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/29369186/cervical-disc-arthroplasty-with-prestige-lp-for-the-treatment-of-contiguous-2-level-cervical-degenerative-disc-disease-5-year-follow-up-results
#14
Xinlin Gao, Yi Yang, Hao Liu, Yang Meng, Junfeng Zeng, Tingkui Wu, Ying Hong
The objective of this study is to present the long-term results and to evaluate the safety and effectiveness of the Prestige-LP cervical disc replacement in treatment of patients with symptomatic 2-level cervical degenerative disc disease.Twenty-four patients with 48 Prestige-LP disc were analyzed before surgery and at 1 week, 3 months, 6 months, 12 months, 24 months, and 60 months after surgery. Clinical assessments included 36-Short Form (SF-36), Japanese Orthopedic Assessment (JOA), visual analog scale (VAS), and Neck Disability Index (NDI) scores...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29355455/biologic-therapies-to-enhance-intervertebral-disc-repair
#15
Eduardo Anitua, Sabino Padilla
Degenerative disc disease is a progressive, chronic disorder with strong association to pain, where the dysregulated tissue environment signals disc cells, thereby leading to a low inflammatory process and slow extracellular matrix degradation and fibrosis in a perpetual vicious cycle, generating a structural and functional failure of intervertebral disc joint (IVDJ). Among current biologic therapies, there is an emerging minimally invasive strategy that consists of infiltrating plasma rich in growth factors, a safe and efficacious therapeutic approach for other musculoskeletal degenerative conditions...
January 22, 2018: Regenerative Medicine
https://www.readbyqxmd.com/read/29354759/a-rare-cause-of-late-onset-neurological-deficit-in-post-tuberculous-kyphotic-deformity-case-report
#16
Suresh Subramani, Ajoy Prasad Shetty, Rishi M Kanna, Shanmuganathan Rajasekaran
Late onset neurological deficit is a rare complication of spinal tuberculosis. Reactivation of the disease and compression by internal gibbus are the common causes for late onset neurological deficit. We report a rare cause of late onset paraplegia in a patient with post tubercular kyphotic deformity. The late onset neurological deficit was due to the adjacent segment degeneration proximal to the kyphotic deformity. Posterior hypertrophied ligamentum flavum and anterior disc osteophyte complex caused the cord compression...
December 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29352194/sirt6-overexpression-suppresses-senescence-and-apoptosis-of-nucleus-pulposus-cells-by-inducing-autophagy-in-a-model-of-intervertebral-disc-degeneration
#17
Jian Chen, Jun-Jun Xie, Meng-Yun Jin, Yun-Tao Gu, Cong-Cong Wu, Wei-Jun Guo, Ying-Zhao Yan, Zeng-Jie Zhang, Jian-Le Wang, Xiao-Lei Zhang, Yan Lin, Jia-Li Sun, Guang-Hui Zhu, Xiang-Yang Wang, Yao-Sen Wu
Treatment of intervertebral disc degeneration (IDD) seeks to prevent senescence and death of nucleus pulposus (NP) cells. Previous studies have shown that sirt6 exerts potent anti-senescent and anti-apoptotic effects in models of age-related degenerative disease. However, it is not known whether sirt6 protects against IDD. Here, we explored whether sirt6 influenced IDD. The sirt6 level was reduced in senescent human NP cells. Sirt6 overexpression protected against apoptosis and both replicative and stress-induced premature senescence...
January 19, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29349958/-biomechanical-analysis-of-the-correlation-between-sacral-tilt-displacement-and-l%C3%A2-s%C3%A2-disc-degeneration
#18
Ning-Ning Shi, Guo-Quan Shen, Shui-Yong He, Ru-Bao Gu, Shui-Yong He
OBJECTIVE: To biomechanical analysis of the correlation between sacral tilt displacement and L₅-S₁ disc degeneration. METHODS: From July 2011 to July 2013, 81 patients with lumbar disc herniation and sacroiliac joint disorder including 45 males and 36 females with an average age of (45.39±1.30) years ranging from 18 to 65 years old were selected. The course of the disease ranged from 1 to 144 months with an average of (12.64±2.19) months. All patients were taken lumbar spine lateral X-ray films, the lumbar curvature angle, L₄-L₅ or L₅-S₁ intervertebral gap distance between points, and the lumbosacral angle was measured and correlated analyzed...
March 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29348392/rapamycin-prevents-the-intervertebral-disc-degeneration-via-inhibiting-differentiation-and-senescence-of-annulus-fibrosus-cells
#19
Changhong Gao, Bin Ning, Chenglin Sang, Ying Zhang
The effects of bleomycin and rapamycin on cellular senescence and differentiation of rabbit annulus fibrosus stem cells (AFSCs) were investigated using a cell culture model. The results showed that bleomycin induced cellular senescence in AFSCs as evidenced by senescence-associated secretory phenotype. The morphology of AFSCs was changed from cobblestone-like cells to pancake-like cells. The senescence-associated β-galactosidase activity, the protein expression of P16 and P21, and inflammatory-related marker gene levels IL-1β, IL-6, and TNF-α were increased in bleomycin-treated AFSCs in a dose-dependent manner...
January 18, 2018: Aging
https://www.readbyqxmd.com/read/29322911/comparison-of-lumbar-pedicular-dynamic-stabilisation-systems-versus-fusion-for-the-treatment-of-lumbar-degenerative-disc-disease-a-meta-analysis
#20
Y-J Huang, S-J Zhao, Q Zhang, L-M Nong, N-W Xu
This study aimed to systematically compare the safety, effectiveness and radiological changes after lumbar pedicular dynamic stabilisation systems and fusion to treat lumbar degenerative disc disease . All studies that were performed to compare various lumbar pedicular dynamic stabilisation systems with any lumbar fusion to treat lumbar degenerative disc disease and were published until April 30, 2015 were acquired through a comprehensive search in various databases. A meta-analysis was performed after the methodological qualities of trials were assessed and after data were extracted...
March 2017: Acta Orthopaedica Belgica
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