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https://www.readbyqxmd.com/read/29160745/the-unveiling-of-the-warburg-effect-and-the-inscribed-innovative-approach-to-a-radical-non-toxic-anticancer-therapy
#1
Olivia Crociani, Ilaria Marzi, Maria Grazia Cipolleschi, Antonella Mannini, Massimo Contini, Massimo Olivotto
The purpose of this research has been deciphering the Warburg paradox, the biochemical enigma unsolved since 1923. This paradox consists of the aerobic pyruvate conversion to lactate brought about by anaplastic cancer, through the metabolic pathway known as aerobic glycolysis. This pathway implies a heavy energetic waste. We solved the enigma by demonstrating that its specific character, i.e. the forced aerobic lactate exportation, represents a crucial metabolic device to counteract the cytotoxic effect produced by an excess of pyruvate at the connection of glycolysis with the Krebs cycle...
November 21, 2017: Cell Cycle
https://www.readbyqxmd.com/read/29157367/a-multilevel-study-of-the-environmental-determinants-of-swine-ascariasis-in-england
#2
Ângelo Joel Mendes, Ana Isabel Ribeiro, Milton Severo, João Niza-Ribeiro
Ascariasis is considered a common parasitosis of swine worldwide. The disease causes significant economic losses due to its effect on feed conversion ratio and liver condemnations at slaughter (liver milk spots). This study aimed to characterise the between-farm and spatial variance in porcine ascariasis in England and to assess the association between the percentage of infected animals and potential environmental risk factors, including production system, socioeconomic deprivation, soil characteristics (pH, topsoil bulk density, topsoil organic matter, topsoil texture class, soil water regime, topsoil available water capacity, and elevation), and climatic conditions (relative humidity, air temperature, and rainfall) before slaughter...
December 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29154147/selecting-the-minimum-data-set-and-quantitative-soil-quality-indexing-of-alkaline-soils-under-different-land-uses-in-northeastern-china
#3
Pujia Yu, Shiwei Liu, Liang Zhang, Qiang Li, Daowei Zhou
Understanding the influences of land use conversions on soil quality (SQ) and function are essential to adopt proper agricultural management practices for a specific region. The primary objective of this study was to develop soil quality indices (SQIs) to assess the short-term influences of different land uses on SQ in semiarid alkaline grassland in northeastern China. Land use treatments were corn cropland (Corn), alfalfa perennial forage (Alfalfa), monoculture Lyemus chinensis grassland (MG) and successional regrowth grassland (SRG), which were applied for five years...
November 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29150403/the-cortisol-reactivity-threshold-model-direction-of-trait-rumination-and-cortisol-reactivity-association-varies-with-stressor-severity
#4
Suzanne Vrshek-Schallhorn, Bradley M Avery, Maria Ditcheva, Vaibhav R Sapuram
Various internalizing risk factors predict, in separate studies, both augmented and reduced cortisol responding to lab-induced stress. Stressor severity appears key: We tested whether heightened trait-like internalizing risk (here, trait rumination) predicts heightened cortisol reactivity under modest objective stress, but conversely predicts reduced reactivity under more robust objective stress. Thus, we hypothesized that trait rumination would interact with a curvilinear (quadratic) function of stress severity to predict cortisol reactivity...
November 8, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29148772/electromechanical-properties-of-ba-1-x-srxtio3-perovskite-solid-solutions-from-first-principles-calculations
#5
Leonid L Rusevich, Guntars Zvejnieks, Alessandro Erba, Roberto Dovesi, Eugene E Kotomin
An enhancement of the piezoelectric properties of lead-free materials, which allow conversion of mechanical energy into electricity, is a task of great importance and interest. Results of first-principles calculations of piezoelectric/electromechanical properties of the Ba(1-x)SrxTiO3 (BSTO) ferroelectric solid solution with perovskite structure are presented and discussed. Calculations are performed within the linear combination of atomic orbitals (LCAO) approximation and periodic-boundary conditions, using advanced hybrid functionals of the density-functional-theory (DFT)...
November 17, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29141489/non-linear-conversion-of-hx4-uptake-for-automatic-segmentation-of-hypoxic-volumes-and-dose-prescription
#6
Ana Ureba, Emely Lindblom, Alexandru Dasu, Johan Uhrdin, Aniek J G Even, Wouter van Elmpt, Philippe Lambin, Peter Wersäll, Iuliana Toma-Dasu
BACKGROUND: Tumour hypoxia is associated with increased radioresistance and poor response to radiotherapy. Pre-treatment assessment of tumour oxygenation could therefore give the possibility to tailor the treatment by calculating the required boost dose needed to overcome the increased radioresistance in hypoxic tumours. This study concerned the derivation of a non-linear conversion function between the uptake of the hypoxia-PET tracer (18)F-HX4 and oxygen partial pressure (pO2). MATERIAL AND METHODS: Building on previous experience with FMISO including experimental data on tracer uptake and pO2, tracer-specific model parameters were derived for converting the normalised HX4-uptake at the optimal imaging time point to pO2...
November 16, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29140390/a-carboxylated-graphene-nanodisks-glucose-oxidase-nanotags-and-mn-cds-tio2-matrix-based-dual-signal-amplification-strategy-for-ultrasensitive-photoelectrochemical-detection-of-tumor-markers
#7
Jie Song, Shuo Wu, Xinlan Yang, Jingli Yuan
Graphene nanodisks with good conductivity and plenty of edge sites were synthesized to load glucose oxidase (GRD-GOD) and coupled with a Mn(2+) doped CdS quantum dot (QD) modified TiO2 electrode (CdS:Mn/TiO2) for a highly sensitive photoelectrochemical (PEC) immunoassay. The specific immune-recognition behaviour can bring the GRD-GOD labelled antigen into the antibody immobilized CdS:Mn/TiO2 interface and dramatically enhance the photocurrent response via a dual signal amplification strategy. First, graphene nanodisks with a strong electron transfer capacity can improve the conductivity of both the insulating protein layers and the CdS:Mn/TiO2 matrix, thus facilitating the regeneration of trapped carriers and hot electrons in the CdS:Mn QD films and enhancing the PEC performance...
November 15, 2017: Analyst
https://www.readbyqxmd.com/read/29130981/endocranial-casts-of-pre-mammalian-therapsids-reveal-an-unexpected-neurological-diversity-at-the-deep-evolutionary-root-of-mammals
#8
Julien Benoit, Vincent Fernandez, Paul R Manger, Bruce S Rubidge
The origin and evolution of the mammalian brain has long been the focus of scientific enquiry. Conversely, little research has focused on the palaeoneurology of the stem group of Mammaliaformes, the Permian and Triassic non-mammaliaform Therapsida (NMT). This is because the majority of the NMT have a non-ossified braincase, making the study of their endocranial cast (sometimes called the "fossil brain") problematic. Thus, descriptions of the morphology and size of NMT endocranial casts have been based largely on approximations rather than reliable determination...
November 8, 2017: Brain, Behavior and Evolution
https://www.readbyqxmd.com/read/29130901/quantification-of-fat-fraction-in-lumbar-vertebrae-correlation-with-age-and-implications-for-bone-marrow-dosimetry-in-molecular-radiotherapy
#9
Maikol Salas-Ramirez, Johannes Tran-Gia, Christian Kesenheimer, Andreas Max Weng, Aleksander Kosmala, Anke Heidemeier, Herbert Koestler, Michael Lassmann
Absorbed dose to active bone marrow is a predictor of hematological toxicity in molecular radiotherapy. Due to the complex composition of bone marrow tissue, the necessity to improve the personalized dosimetry has led to the application of non-conventional imaging methods in nuclear medicine. The aim of this study is to apply magnetic resonance imaging (MRI) for quantification of the fat fraction in lumbar vertebrae and to analyze its implications for bone marrow dosimetry. Methods First, a highly accelerated two-point Dixon MRI sequence for fat-water separation was validated in a 3T system against the magnetic resonance spectroscopy (MRS) gold standard...
November 13, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29130537/evaluation-of-renal-metabolic-response-to-partial-ureteral-obstruction-with-hyperpolarized-13-c-mri
#10
David J Niles, Jeremy W Gordon, Gengwen Huang, Shannon Reese, Erin B Adamson, Arjang Djamali, Sean B Fain
Hyperpolarized (13) C magnetic resonance imaging (MRI) may be used to non-invasively image the transport and chemical conversion of (13) C-labeled compounds in vivo. In this study, we utilize hyperpolarized (13) C MRI to evaluate metabolic markers in the kidneys longitudinally in a mouse model of partial unilateral ureteral obstruction (pUUO). Partial obstruction was surgically induced in the left ureter of nine adult mice, leaving the right ureter as a control. (1) H and hyperpolarized [1-(13) C]pyruvate MRI of the kidneys was performed 2 days prior to surgery (baseline) and at 3, 7 and 14 days post-surgery...
November 12, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29128225/a-longitudinal-study-of-gastrointestinal-parasites-in-english-dairy-farms-practices-and-factors-associated-with-first-lactation-heifer-exposure-to-ostertagia-ostertagi-on-pasture
#11
C Bellet, M J Green, A J Bradley, J Kaler
The gastrointestinal nematode Ostertagia ostertagi is an important cause of lost production, health, and welfare in cattle. Detailed records were obtained over a 5-yr period (2010-2015) by questionnaires and qualitative interviews to investigate the practices adopted by dairy farmers to control cattle helminth infections and the factors associated with heifer exposure to O. ostertagi on pasture. In total, 1,454 heifers' individual milk samples were collected over a 1-yr period (2014-2015) in 43 dairy farms in England and tested for O...
November 8, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29121342/yellow-mealworm-larvae-tenebrio-molitor-inclusion-in-diets-for-male-broiler-chickens-effects-on-growth-performance-gut-morphology-and-histological-findings
#12
I Biasato, L Gasco, M De Marco, M Renna, L Rotolo, S Dabbou, M T Capucchio, E Biasibetti, M Tarantola, L Sterpone, L Cavallarin, F Gai, L Pozzo, S Bergagna, D Dezzutto, I Zoccarato, A Schiavone
This study evaluated the effects of Tenebrio molitor (TM) larvae meal inclusion in diets for broilers. A total of 160 male broiler chicks (Ross 708) at one-day of age were randomly allotted to four dietary treatments: a control (C) group and three TM groups, in which TM meal was included at 50 (TM5), 100 (TM10), and 150 (TM15) g/kg, respectively. The experimental diets were isonitrogenous and isoenergetic. Each group consisted of five pens as replicates (8 chicks/pen). After the evaluation of growth performance and haematochemical parameters, the animals were slaughtered at 53 days and carcass traits were recorded...
November 7, 2017: Poultry Science
https://www.readbyqxmd.com/read/29117132/rationally-controlled-synthesis-of-cdsexte1-x-alloy-nanocrystals-and-their-application-in-efficient-graded-bandgap-solar-cells
#13
Shiya Wen, Miaozi Li, Junyu Yang, Xianglin Mei, Bin Wu, Xiaolin Liu, Jingxuan Heng, Donghuan Qin, Lintao Hou, Wei Xu, Dan Wang
CdSexTe1-x semiconductor nanocrystals (NCs), being rod-shaped/irregular dot-shaped in morphology, have been fabricated via a simple hot-injection method. The NCs composition is well controlled through varying molar ratios of Se to Te precursors. Through changing the composition of the CdSexTe1-x NCs, the spectral absorption of the NC thin film between 570-800 nm is proved to be tunable. It is shown that the bandgap of homogeneously alloyed CdSexTe1-x active thin film is nonlinearly correlated with the different compositions, which is perceived as optical bowing...
November 8, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29111661/using-p-type-pbs-quantum-dots-to-quench-photocurrent-of-fullerene-au-np-mos2-composite-structure-for-ultrasensitive-photoelectrochemical-detection-of-atp
#14
Meng-Jie Li, Ying-Ning Zheng, Wen-Bin Liang, Ruo Yuan, Ya-Qin Chai
Ultrasensitive and rapid quantification of the universal energy currency adenosine triphosphate (ATP) is an extremely critical mission in clinical applications. In this work, a "signal-off" photoelectrochemical (PEC) biosensor was designed for ultrasensitive ATP detection based on a fullerene (C60)-decorated Au nanoparticle@MoS2 (C60-Au NP@MoS2) composite material as a signal indicator and a p-type PbS quantum dot (QD) as an efficient signal quencher. Modification of wide band gap C60 with narrow band gap MoS2 to form an ideal PEC signal indicator was proposed, which could significantly improve photocurrent conversion efficiency, leading to a desirable PEC signal...
November 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29110271/induced-bias-due-to-crossover-within-randomized-controlled-trials-in-surgical-oncology-a-meta-regression-analysis-of-minimally-invasive-versus-open-surgery-for-the-treatment-of-gastrointestinal-cancer
#15
REVIEW
George Garas, Sheraz R Markar, George Malietzis, Hutan Ashrafian, George B Hanna, Emmanouil Zacharakis, Long R Jiao, Athanassios Argiris, Ara Darzi, Thanos Athanasiou
BACKGROUND: Randomized controlled trials (RCTs) inform clinical practice and have provided the evidence base for introducing minimally invasive surgery (MIS) in surgical oncology. Crossover (unplanned intraoperative conversion of MIS to open surgery) may affect clinical outcomes and the effect size generated from RCTs with homogenization of randomized groups. OBJECTIVES: Our aims were to identify modifiable factors associated with crossover and assess the impact of crossover on clinical endpoints...
November 6, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29102166/association-between-physical-activity-and-the-expression-of-mediators-of-inflammation-in-normal-breast-tissue-among-premenopausal-and-postmenopausal-women
#16
Mirette Hanna, Isabelle Dumas, Michèle Orain, Simon Jacob, Bernard Têtu, Caroline Diorio
Physical activity is associated with decreased breast cancer risk. The underlying biological mechanisms could include the reduction of the local inflammation in the breast tissue. We conducted a cross-sectional study to assess the association between the physical activity and the protein expression levels of eleven mediators of inflammation in normal breast tissue of 164 women having breast cancer. Information on total physical activity (household, occupational and recreational) performed during a one-year period was collected using a questionnaire...
October 26, 2017: Cytokine
https://www.readbyqxmd.com/read/29101905/conversion-factors-for-assessment-of-driving-impairment-after-exposure-to-multiple-benzodiazepines-z-hypnotics-or-opioids
#17
Maren Cecilie Strand, Jørg Mørland, Lars Slørdal, Bettina Riedel, Cato Innerdal, Trond Aamo, Grete Mathisrud, Vigdis Vindenes
AIMS: Norway has introduced legal concentration limits in blood for 28 non-alcohol drugs in driving under the influence cases. As of 2016 this legislation also regulates the assessment of combined effects of multiple benzodiazepines and opioids. We herein describe the employed methodology for the equivalence tables for concentrations of benzodiazepines/z-hypnotics and opioids implemented in the Norwegian Road Traffic Act. METHODS: Legislative limits corresponding to impairment at blood alcohol concentrations (BAC) of 0...
October 20, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29100660/tracting-the-neural-basis-of-music-deficient-structural-connectivity-underlying-acquired-amusia
#18
Aleksi J Sihvonen, Pablo Ripollés, Teppo Särkämö, Vera Leo, Antoni Rodríguez-Fornells, Jani Saunavaara, Riitta Parkkola, Seppo Soinila
Acquired amusia provides a unique opportunity to investigate the fundamental neural architectures of musical processing due to the transition from a functioning to defective music processing system. Yet, the white matter (WM) deficits in amusia remain systematically unexplored. To evaluate which WM structures form the neural basis for acquired amusia and its recovery, we studied 42 stroke patients longitudinally at acute, 3-month, and 6-month post-stroke stages using DTI [tract-based spatial statistics (TBSS) and deterministic tractography (DT)] and the Scale and Rhythm subtests of the Montreal Battery of Evaluation of Amusia (MBEA)...
October 10, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29099196/topologically-protected-complete-polarization-conversion
#19
Yu Guo, Meng Xiao, Shanhui Fan
We consider the process of conversion between linear polarizations as light is reflected from a photonic crystal slab. We observe that, over a wide range of frequencies, complete polarization conversion can be found at isolated wave vectors. Moreover, such an effect is topological: the complex reflection coefficients have a nonzero winding number in the wave vector space. We also show that bound states in continuum in this system have their wave vectors lying on the critical coupling curve that defines the condition for complete polarization conversion...
October 20, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29098772/crystal-and-nmr-structures-of-a-peptidomimetic-%C3%AE-turn-which-provides-facile-synthesis-of-13-membered-cyclic-tetrapeptides
#20
Alan James Cameron, Christopher J Squire, Patrick J B Edwards, Elena Harjes, Vijayalekshmi Sarojini
Herein we report the unique conformations adopted by linear and cyclic tetrapeptides (CTPs) containing 2-aminobenzoic acid (2-Abz) in solution and as single crystals. The crystal structure of the linear tetrapeptide H2N-D-Leu-D-Phe-2-Abz-D-Ala-COOH (1) reveals a novel planar peptidomimetic β-turn stabilized by three hydrogen bonds and is in agreement with its NMR structure in solution. While CTPs are often synthetically inaccessible or cyclize in poor yield, both 1 and its N-Me-D-Phe analogue (2) adopt pseudo-cyclic frameworks enabling near quantitative conversion to the corresponding CTPs 3 and 4...
November 2, 2017: Chemistry, An Asian Journal
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