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https://www.readbyqxmd.com/read/28340135/modeling-longitudinal-data-and-its-impact-on-survival-in-observational-nephrology-studies-tools-and-considerations
#1
Elani Streja, Leanne Goldstein, Melissa Soohoo, Yoshitsugu Obi, Kamyar Kalantar-Zadeh, Connie M Rhee
Nephrologists and kidney disease researchers are often interested in monitoring how patients' clinical and laboratory measures change over time, what factors may impact these changes, and how these changes may lead to differences in morbidity, mortality, and other outcomes. When longitudinal data with repeated measures over time in the same patients are available, there are a number of analytical approaches that could be employed to describe the trends and changes in these measures, and to explore the associations of these changes with outcomes...
March 3, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28339708/effects-of-dietary-methyl-sulfonyl-methane-msm-supplementation-on-growth-performance-nutrient-digestibility-meat-quality-excreta-microbiota-excreta-gas-emission-and-blood-profiles-in-broilers
#2
Y Jiao, J H Park, Y M Kim, I H Kim
A 29-d trial was conducted to evaluate the effects of dietary methyl sulfonyl methane (MSM) supplementation on growth performance, meat quality, nutrient digestibility, excreta microbiota, excreta gas emission, and blood profiles in broilers. A total of 816 1-day-old male Ross 308 broilers (44 ± 0.44 g) were assigned to 4 dietary treatments, composed of 12 replicates with 17 birds per replicate. The 4 treatments were: 1) CON, basal diet; 2) S1, CON + 0.05% MSM; 3) S2, CON + 0.10% MSM; 4) S3, CON + 0.20% MSM...
February 22, 2017: Poultry Science
https://www.readbyqxmd.com/read/28335366/nano-copper-oxide-modified-carbon-cloth-as-cathode-for-a-two-chamber-microbial-fuel-cell
#3
Feng Dong, Peng Zhang, Kexun Li, Xianhua Liu, Pingping Zhang
In this work, Cu₂O nanoparticles were deposited on a carbon cloth cathode using a facile electrochemical method. The morphology of the modified cathode, which was characterized by scanning electron microscopy (SEM) and Brunauer-Emmett-Teller (BET) tests, showed that the porosity and specific surface area of the cathode improved with longer deposition times. X-ray photoelectron spectroscopy (XPS) and cyclic voltammetry (CV) results showed that cupric oxide and cuprous oxide coexisted on the carbon cloth, which improved the electrochemical activity of cathode...
December 9, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28331773/characteristics-and-factors-associated-with-antihypertensive-medication-use-in-patients-attending-peruvian-health-facilities
#4
Christian R Mejia, Virgilio E Failoc-Rojas, Edison So, Carmen Cervantes, Antonio J Aspajo, Jesus Galileo Leandro, Jhomar Cordova-De La Cruz, Julio C Charri, Kevin E García-Auqui, Lelis Gabriela Coronel-Chucos, Luz Delia Justo-Pinto, Marisol Stefanie Mamani-Apaza, Neil Arón Paz-Campos, Ricardo Correa
INTRODUCTION : Hypertension is a very common disease worldwide, and medication is needed to prevent its short-term and long-term complications. Our objective was to determine the characteristics and factors associated with antihypertensive medication use in patients attending Peruvian health facilities. MATERIALS & METHODS: We performed a multicenter, cross-sectional study with secondary data. We obtained self-reported antihypertensive medication from patients attending health facilities in 10 departments of Peru...
February 3, 2017: Curēus
https://www.readbyqxmd.com/read/28320766/an-adverse-lipid-profile-and-increased-levels-of-adiposity-significantly-predict-clinical-course-after-a-first-demyelinating-event
#5
Prudence Tettey, Steve Simpson, Bruce Taylor, Anne-Louise Ponsonby, Robyn M Lucas, Terence Dwyer, Karam Kostner, Ingrid Af van der Mei
OBJECTIVE: To investigate the prospective associations between adiposity and lipid-related variables and conversion to multiple sclerosis (MS), time to subsequent relapse and progression in disability. METHODS: A cohort of 279 participants with a first clinical diagnosis of central nervous system demyelination was prospectively followed to 5-year review. Height, weight, waist and hip circumference were measured, and serum samples taken for measurement of lipids and apolipoproteins...
March 20, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28319832/comparative-life-cycle-cost-assessment-of-painted-and-hot-dip-galvanized-bridges
#6
B Rossi, S Marquart, G Rossi
The study addresses the life cycle cost assessment (LCCA) of steel bridges, focusing on the maintenance activities and the maintenance scenario. Firstly, the unit costs of maintenance activities and their durability (i.e. the time between two activities) are evaluated. Pragmatic data are provided for the environment category C4 and for three activities: Patch Up, Overcoating and Remove & Replace. A comparative LCCA for a typical hypothetic steel girder bridge is carried out, either painted or hot-dip galvanized (HDG), in the environmental class C4...
March 17, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28318540/physical-and-mental-health-of-children-with-substantiated-sexual-abuse-gender-comparisons-from-a-matched-control-cohort-study
#7
Isabelle Daigneault, Pascale Vézina-Gagnon, Catherine Bourgeois, Tonino Esposito, Martine Hébert
When compared to children from the general population, sexually abused children receive more medical services, both for physical and mental health problems. However, possible differences between sexually abused boys and girls remain unknown. The lack of control group in studies that find gender differences also prevents from determining if the differences are specific to sexual abuse or to gender. The objective of the study was to assess differences in physical and mental health between sexually abused boys and girls in comparison to those from the general population...
March 15, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28315593/ingan-gan-nanowires-as-a-new-platform-for-photoelectrochemical-sensors-detection-of-nadh
#8
M Riedel, S Hölzel, P Hille, J Schörmann, M Eickhoff, F Lisdat
InGaN/GaN nanowire heterostructures are presented as nanophotonic probes for the light-triggered photoelectrochemical detection of NADH. We demonstrate that photogenerated electron-hole pairs give rise to a stable anodic photocurrent whose potential- and pH-dependences exhibit broad applicability. In addition, the simultaneous measurement of the photoluminescence provides an additional tool for the analysis and evaluation of light-triggered reaction processes at the nanostructured interface. InGaN/GaN nanowire ensembles can be excited over a wide wavelength range, which avoids interferences of the photoelectrochemical response by absorption properties of the compounds to be analyzed by adjusting the excitation wavelength...
March 11, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28296899/the-effects-of-marine-traffic-on-the-behaviour-of-black-sea-harbour-porpoises-phocoena-phocoena-relicta-within-the-istanbul-strait-turkey
#9
Aylin Akkaya Bas, Fredrik Christiansen, Ayaka Amaha Öztürk, Bayram Öztürk, Caley McIntosh
Marine traffic is threatening cetaceans on a local and global scale. The Istanbul Strait is one of the busiest waterways, with up to 2,500 vessels present daily. This is the first study to assess the magnitude of short- and long-term behavioural changes of the endangered Black Sea harbour porpoises (Phocoena phocoena relicta) in the presence of marine vessels within the Istanbul Strait. Markov chains were used to investigate the effect of vessel presence on the transition probability between behavioural states (diving, surface-feeding and travelling), and to quantify the effect on the behavioural budget and bout length (duration of time spent in a given state) of porpoises...
2017: PloS One
https://www.readbyqxmd.com/read/28296305/on-flattening-filter-free-portal-dosimetry
#10
Eduardo Pardo, Juan Castro Novais, María Yolanda Molina López, Sheila Ruiz Maqueda
Varian introduced (in 2010) the option of removing the flattening filter (FF) in their C-Arm linacs for intensity-modulated treatments. This mode, called flattening filter-free (FFF), offers the advantage of a greater dose rate. Varian's "Portal Dosimetry" is an electronic portal imager device (EPID)-based tool for IMRT verification. This tool lacks the capability of verifying flattening filter-free (FFF) modes due to saturation and lack of an image prediction algorithm. (Note: the latest versions of this software and EPID correct these issues...
July 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28291935/helical-tomotherapy-to-linac-plan-conversion-utilizing-raystation-fallback-planning
#11
Xin Zhang, Jose Penagaricano, Ganesh Narayanasamy, Peter Corry, TianXiao Liu, Maraboyina Sanjay, Nava Paudel, Steven Morrill
RaySearch RayStation Fallback (FB) planning module can generate an equivalent backup radiotherapy treatment plan facilitating treatment on other linear accelerators. FB plans were generated from the RayStation FB module by simulating the original plan target and organ at risk (OAR) dose distribution and delivered in various backup linear accelerators. In this study, helical tomotherapy (HT) backup plans used in Varian TrueBeam linear accelerator were generated with the RayStation FB module. About 30 patients, 10 with lung cancer, 10 with head and neck (HN) cancer, and 10 with prostate cancer, who were treated with HT, were included in this study...
January 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28291612/additive-or-non-additive-effect-of-mixing-oak-in-pine-stands-on-soil-properties-depends-on-the-tree-species-in-mediterranean-forests
#12
Caroline Brunel, Raphael Gros, Fabio Ziarelli, Anne Marie Farnet Da Silva
This study investigated how oak abundance in pine stands (using relative Oak Basal Area %, OBA%) may modulate soil microbial functioning. Forests were composed of sclerophyllous species i.e. Quercus ilex mixed with Pinus halepensis Miller or of Q. pubescens mixed with P. sylvestris. We used a series of plots with OBA% ranging from 0 to 100% in the two types of stand (n=60) and both OLF and A-horizon compartments were analysed. Relations between OBA% and either soil chemical (C and N contents, quality of organic matter via solid-state NMR, pH, CaCO3) or microbial (enzyme activities, basal respiration, biomass and catabolic diversity via BIOLOG) characteristics were described...
March 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28287090/controllable-conversion-of-quasi-freestanding-polymer-chains-to-graphene-nanoribbons
#13
Chuanxu Ma, Zhongcan Xiao, Honghai Zhang, Liangbo Liang, Jingsong Huang, Wenchang Lu, Bobby G Sumpter, Kunlun Hong, J Bernholc, An-Ping Li
In the bottom-up synthesis of graphene nanoribbons (GNRs) from self-assembled linear polymer intermediates, surface-assisted cyclodehydrogenations usually take place on catalytic metal surfaces. Here we demonstrate the formation of GNRs from quasi-freestanding polymers assisted by hole injections from a scanning tunnelling microscope (STM) tip. While catalytic cyclodehydrogenations typically occur in a domino-like conversion process during the thermal annealing, the hole-injection-assisted reactions happen at selective molecular sites controlled by the STM tip...
March 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/28286479/detection-of-conversion-from-mild-cognitive-impairment-to-alzheimer-s-disease-using-longitudinal-brain-mri
#14
Zhuo Sun, Martijn van de Giessen, Boudewijn P F Lelieveldt, Marius Staring
Mild Cognitive Impairment (MCI) is an intermediate stage between healthy and Alzheimer's disease (AD). To enable early intervention it is important to identify the MCI subjects that will convert to AD in an early stage. In this paper, we provide a new method to distinguish between MCI patients that either convert to Alzheimer's Disease (MCIc) or remain stable (MCIs), using only longitudinal T1-weighted MRI. Currently, most longitudinal studies focus on volumetric comparison of a few anatomical structures, thereby ignoring more detailed development inside and outside those structures...
2017: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/28283226/differential-impact-of-net-atrioventricular-compliance-on-clinical-outcomes-in-patients-with-mitral-stenosis-according-to-cardiac-rhythm
#15
In-Jeong Cho, Hyuk-Jae Chang, Soo Yeon Lee, Chi Young Shim, Geu-Ru Hong, Namsik Chung
BACKGROUND: Net atrioventricular compliance (Cn), a parameter for the net compliance of the left atrium and left ventricle, is known to be a useful predictor of outcomes in patients with mitral stenosis (MS). The present study aimed to evaluate whether the impact of Cn on symptom status and clinical outcomes, as well as its contribution toward systolic pulmonary artery pressure (SPAP), differed according to cardiac rhythm. METHODS: We retrospectively reviewed patients (N = 308) with rheumatic pure MS...
March 7, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28283045/how-equitable-is-the-uptake-of-conditional-cash-transfers-for-maternity-care-in-india-evidence-from-the-janani-suraksha-yojana-scheme-in-odisha-and-jharkhand
#16
Nattawut Thongkong, Ellen van de Poel, Swati Sarbani Roy, Shibanand Rath, Tanja A J Houweling
BACKGROUND: In 2005, the Indian Government introduced the Janani Suraksha Yojana (JSY) scheme - a conditional cash transfer program that incentivizes women to deliver in a health facility - in order to reduce maternal and neonatal mortality. Our study aimed to measure and explain socioeconomic inequality in the receipt of JSY benefits. METHODS: We used prospectively collected data on 3,682 births (in 2009-2010) from a demographic surveillance system in five districts in Jharkhand and Odisha state, India...
March 10, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28282586/mapping-axonal-density-and-average-diameter-using-non-monotonic-time-dependent-gradient-echo-mri
#17
Daniel Nunes, Tomás L Cruz, Sune N Jespersen, Noam Shemesh
White Matter (WM) microstructures, such as axonal density and average diameter, are crucial to the normal function of the Central Nervous System (CNS) as they are closely related with axonal conduction velocities. Conversely, disruptions of these microstructural features may result in severe neurological deficits, suggesting that their noninvasive mapping could be an important step towards diagnosing and following pathophysiology. Whereas diffusion based MRI methods have been proposed to map these features, they typically entail the application of powerful gradients, which are rarely available in the clinic, or extremely long acquisition schemes to extract information from parameter-intensive models...
February 28, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28281763/-15-n-h-related-conformational-entropy-changes-entailed-by-plexin-b1-rbd-dimerization-a-combined-molecular-dynamics-nmr-relaxation-approach
#18
Mirco Zerbetto, Eva Meirovitch
We report on a new method for determining function-related conformational entropy changes in proteins. Plexin-B1 RBD dimerization serves as example, and internally-mobile N-H bonds serve as probes. Sk (entropy in units of kBT) is given by -∫(Peq lnPeq)dΩ, where Peq= exp(-u) is the probability density for probe orientation, and u the local potential. Previous SRLS analyses of (15)N-H relaxation in proteins determined linear combinations of D(2)00(Ω) and (D(2)02(Ω) + D(2)0-2(Ω)) (D(L)0K(Ω) - Wigner rotation matrix element in uniaxial local medium) as "best-fit" form of u...
March 10, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28281341/electrochemiluminescence-biosensor-based-on-3-d-dna-nanomachine-signal-probe-powered-by-protein-aptamer-binding-complex-for-ultrasensitive-mucin-1-detection
#19
Xinya Jiang, Haijun Wang, Huijun Wang, Ying Zhuo, Ruo Yuan, Yaqin Chai
Herein, we fabricated a novel electrochemiluminescence (ECL) biosensor for ultrasensitive detection of mucin 1 (MUC1) based on a three-dimensional (3-D) DNA nanomachine signal probe powered by protein-aptamer binding complex. The assembly of 3-D DNA nanomachine signal probe achieved the cyclic reuse of target protein based on the protein-aptamer binding complex induced catalyzed hairpin assembly (CHA), which overcame the shortcoming of protein conversion with enzyme cleavage or polymerization in the traditional examination of protein...
March 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28279874/high-throughput-quantitative-analysis-of-the-%C3%AE-lyase-sulfur-mustard-metabolite-1-1-sulfonylbis-2-methylsulfinyl-ethane-in-urine-via-high-performance-liquid-chromatography-tandem-mass-spectrometry
#20
Martin J Bevan, Matthew T Wogen, Mark D Lunda, Stefan A Saravia
Sulfur Mustard (HD) has a 100year history of use as a chemical warfare agent and recent events in the Middle East are causing it to once again be a potential concern. We report a new high-throughput method for the determination of HD exposure by the analysis of the β-lyase metabolite 1,1'-sulfonylbis[2-(methylsulfinyl)ethane] (SBMSE) in human urine. This method features a hydrogen peroxide (H2O2) oxidative conversion of the β-lyase metabolites to SBMSE, followed by sample extraction and concentration using solid phase extraction in 96-well plate format...
March 3, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
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