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https://www.readbyqxmd.com/read/28634839/outcomes-of-kidney-donors-over-60%C3%A2-years-old-a-single-center-cohort-study
#1
Daniel Gero, Fadia Dib, Maurice Matter, Manuel Pascual, Jean-Pierre Venetz, Nicolas Demartines, Emmanuel Melloul
AIM: To evaluate outcomes and post-donation kidney function of older living kidney donors (LKD). METHODS: Retrospective analysis of prospective database including all consecutive LKD undergoing laparoscopic nephrectomy in a single center (09/1998-12/2013). LKD aged ≥60 years were compared to younger LKD. Renal function assessed by creatinine levels and estimated glomerular filtration rates (eGFR). Surgical complications classified according to the Clavien-Dindo classification...
June 20, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28634656/patient-reported-eortc-qlq-cipn20-versus-physician-reported-ctcae-quantification-of-oxaliplatin-and-paclitaxel-carboplatin-induced-peripheral-neuropathy-in-ncctg-alliance-clinical-trials
#2
Jennifer Le-Rademacher, Rahul Kanwar, Drew Seisler, Deirdre R Pachman, Rui Qin, Alexej Abyzov, Kathryn J Ruddy, Michaela S Banck, Ellen M Lavoie Smith, Susan G Dorsey, Neil K Aaronson, Jeff Sloan, Charles L Loprinzi, Andreas S Beutler
PURPOSE: Clinical practice guidelines on chemotherapy-induced peripheral neuropathy (CIPN) use the NCI Common Terminology Criteria for Adverse Events (CTCAE), while recent clinical trials employ a potentially superior measure, the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-CIPN twenty-item scale (QLQ-CIPN20), a patient-reported outcome (PRO). Practitioners and researchers lack guidance, regarding how QLQ-CIPN20 results relate to the traditional CTCAE during the serial assessment of patients undergoing chemotherapy...
June 20, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28633056/exploratory-analysis-of-normative-performance-on-the-ucsd-performance-based-skills-assessment-brief
#3
Lea Vella, Thomas L Patterson, Philip D Harvey, Margaret McNamara McClure, Brent T Mausbach, Michael J Taylor, Elizabeth W Twamley
The UCSD Performance-Based Skills Assessment (UPSA) is a performance-based measure of functional capacity. The brief, two-domain (finance and communication ability) version of the assessment (UPSA-B) is now widely used in both clinical research and treatment trials. To date, research has not examined possible demographic-UPSA-B relationships within a non-psychiatric population. We aimed to produce and describe preliminary normative scores for the UPSA-B over a full range of ages and educational attainment. The finance and communication subscales of the UPSA were administered to 190 healthy participants in the context of three separate studies...
June 12, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28631234/quality-matters-implementation-moderates-student-outcomes-in-the-paths-curriculum
#4
Neil Humphrey, Alexandra Barlow, Ann Lendrum
Analyses of the relationship between levels of implementation and outcomes of school-based social and emotional learning (SEL) interventions are relatively infrequent and are typically narrowly focused. Thus, our objective was to assess the relationship between variability in a range of implementation dimensions and intervention outcomes in the Promoting Alternative Thinking Strategies (PATHS) curriculum. Implementation of PATHS was examined in 69 classrooms across 23 schools in the first year of a major randomized controlled trial...
June 19, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/28631047/periodontal-disease-in-chinese-patients-with-systemic-lupus-erythematosus
#5
Qiuxiang Zhang, Xiaoli Zhang, Guijaun Feng, Ting Fu, Rulan Yin, Lijuan Zhang, Xingmei Feng, Liren Li, Zhifeng Gu
Disease of systemic lupus erythematosus (SLE) and periodontal disease (PD) shares the common multiple characteristics. The aims of the present study were to evaluate the prevalence and severity of periodontal disease in Chinese SLE patients and to determine the association between SLE features and periodontal parameters. A cross-sectional study of 108 SLE patients together with 108 age- and sex-matched healthy controls was made. Periodontal status was conducted by two dentists independently. Sociodemographic characteristics, lifestyle factors, medication use, and clinical parameters were also assessed...
June 19, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28630255/social-context-dependent-activity-in-marmoset-frontal-cortex-populations-during-natural-conversations
#6
Samuel U Nummela, Vladimir Jovanovic, Lisa de la Mothe, Cory T Miller
Communication is an inherently interactive process that weaves together the fabric of both human and nonhuman primate societies. To investigate the properties of the primate brain during active social signaling, we recorded the responses of frontal cortex neurons as freely-moving marmosets engaged in conversational exchanges with a visually occluded Virtual Marmoset (VM). We found that small changes in firing rate (∼1Hz) occurred across a broadly distributed population of frontal cortex neurons when marmosets heard a conspecific vocalization, and that these changes corresponded to subjects' likelihood of producing or withholding a vocal reply...
June 19, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28630151/assembly-mechanism-of-the-%C3%AE-pore-forming-toxin-cytolysin-a-from-escherichia-coli
#7
REVIEW
Daniel Roderer, Rudi Glockshuber
The cytolytic toxin cytolysin A (ClyA) from Escherichia coli is probably one of the best-characterized examples of bacterial, α-pore-forming toxins (α-PFTs). Like other PFTs, ClyA exists in a soluble, monomeric form that assembles to an annular, homo-oligomeric pore complex upon contact with detergent or target membranes. Comparison of the three-dimensional structures of the 34 kDa monomer and the protomer in the context of the dodecameric pore complex revealed that ClyA undergoes one of the largest conformational transitions described for proteins so far, in which 55% of the residues change their position and 16% of the residues adopt a different secondary structure in the protomer...
August 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28629110/recycling-the-liquid-fraction-of-alkaline-hydrogen-peroxide-in-the-pretreatment-of-corn-stover
#8
Bárbara Ribeiro Alves Alencar, Alexandre Libanio Silva Reis, Raquel de Fatima Rodrigues de Souza, Marcos Antônio Morais, Rômulo Simões Cezar Menezes, Emmanuel Damilano Dutra
The aim of this study was to evaluate the influence of recycling the liquid fraction of pretreatment with alkaline hydrogen peroxide (AHP) on the hydrolysis of corn stover. Corn stover was pretreated in the traditional condition with 7.5% v/v H2O2. After pretreatment, the solids were separated from the liquid fraction and five successive reuse cycles of the liquid fraction were tested. The solid fraction from pretreatment in each recycle was submitted to enzymatic hydrolysis. The number of recycles had a linear negative effect (R(2)=0...
June 8, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28624618/a-sample-to-answer-real-time-convective-polymerase-chain-reaction-system-for-point-of-care-diagnostics
#9
Bowen Shu, Chunsun Zhang, Da Xing
Timely and accurate molecular diagnostics at the point-of-care (POC) level is critical to global health. To this end, we propose a handheld convective-flow real-time polymerase chain reaction (PCR) system capable of direct sample-to-answer genetic analysis for the first time. Such a system mainly consists of a magnetic bead-assisted photothermolysis sample preparation, a closed-loop convective PCR reactor, and a wireless video camera-based real-time fluorescence detection. The sample preparation exploits the dual functionality of vancomycin-modified magnetic beads (VMBs) for bacteria enrichment and photothermal conversion, enabling cell pre-concentration and lysis to be finished in less than 3min...
June 8, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28618134/potentially-inappropriate-use-of-furosemide-in-a-very-elderly-population-an-observational-study
#10
Carla Rodriguez-Cillero, Didier Menu, Philippe d'Athis, Sophie Perrin, Mélanie Dipanda, Sanaa Asgassou, Hélène Guepet, Emmanuel Mazen, Patrick Manckoundia, Alain Putot
OBJECTIVE: Little is known about furosemide prescription modalities in elderly people. We describe furosemide prescription in ambulatory elderly patients. METHODS: All patients aged over 80 years, affiliated to Mutualité Sociale Agricole de Bourgogne, a French regional health insurance plan, with a medical prescription delivered in March 2015, were retrospectively included. RESULTS: Among 15 141 patients with a median age of 86 years, comprising 61...
June 15, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28614196/superiority-of-serum-cystatin-c-over-creatinine-in-prediction-of-long-term-prognosis-at-discharge-from-icu
#11
Bo Ravn, John R Prowle, Johan Mårtensson, Claes-Roland Martling, Max Bell
OBJECTIVES: Renal outcomes after critical illness are seldom assessed despite strong correlation between chronic kidney disease and survival. Outside hospital, renal dysfunction is more strongly associated with mortality when assessed by serum cystatin C than by creatinine. The relationship between creatinine and longer term mortality might be particularly weak in survivors of critical illness. DESIGN: Retrospective observational cohort study. PATIENTS: In 3,077 adult ICU survivors, we compared ICU discharge cystatin C and creatinine and their association with 1-year mortality...
June 13, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28611450/investigation-of-electric-field-induced-mixing-in-silicon-micro-ring-resonators
#12
Francesco De Leonardis, Richard A Soref, Vittorio M N Passaro
In this paper we present a detailed theoretical investigation of the electric field induced mixing effect, in which the up and down frequency-conversion processes are obtained by inducing an effective second order susceptibility via the periodic spatial distribution of reversed biased p-i-n junctions. The possibility of realizing a frequency generation process within an integrated microring resonator is demonstrated here, by simulations, in the silicon on insulator platform. Furthermore, general physical features have been investigated by means of a comparative analysis of the frequency generation performance as a function of the input pump power, the linear and nonlinear losses, and the coupling factors...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28609621/orchestrating-directional-molecular-motions-kinetically-con-trolled-supramolecular-pathways-of-a-helical-host-on-rod-like-guests
#13
Xiang Wang, Barbara Wicher, Yann Ferrand, Ivan Huc
An aromatic oligoamide sequence was designed to fold and self-assemble into a double helical host having a cylindrical cavity complementary to linear oligo-carbamates guests. Formation of helical pseudo-rotaxane complexes - foldaxanes - between the host and guests having binding stations of different affinities was evidenced by NMR and x-ray crystallog-raphy. Rod-like guests possessing two or three binding stations, long alkyl or oligoethylene glycol spacers or bulky barriers in-between the binding stations, and a single bulky stopper at one end, were synthesized...
June 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28605612/influence-of-different-curing-modes-on-polymerization-behavior-and-mechanical-properties-of-dual-cured-provisional-resins
#14
S Shibasaki, T Takamizawa, T Suzuki, K Nojiri, A Tsujimoto, W W Barkmeier, M A Latta, M Miyazaki
This study determined the influence of curing mode on polymerization behavior and mechanical properties of dual-cured provisional resins. Three dual-cured bisacryl-based provisional resins were used: Tempsmart (TS; GC Corp), Luxatemp Automix Solar (LX; DMG Chemisch Pharmazeutishe Fabrik GmbH), and Integrity Multi·Cure (IG; Dentsply Caulk). A self-cured bisacryl-based provisional resin, Protemp Plus (PP; 3M ESPE) and a conventional poly(methyl methacrylate) (PMMA) provisional resin, Unifast III (UF; GC Corp) were used as controls...
June 12, 2017: Operative Dentistry
https://www.readbyqxmd.com/read/28603473/perioperative-surgical-outcome-of-conventional-and-robot-assisted-total-laparoscopic-hysterectomy
#15
W J van Weelden, B B M Gordon, E A Roovers, A A Kraayenbrink, C I M Aalders, F Hartog, F P H L J Dijkhuizen
BACKGROUND: To evaluate surgical outcome in a consecutive series of patients with conventional and robot assisted total laparoscopic hysterectomy. METHODS: A retrospective cohort study was performed among patients with benign and malignant indications for a laparoscopic hysterectomy. Main surgical outcomes were operation room time and skin to skin operating time, complications, conversions, rehospitalisation and reoperation, estimated blood loss and length of hospital stay...
2017: Gynecological Surgery
https://www.readbyqxmd.com/read/28602281/on-line-gaseous-formaldehyde-detection-by-a-microfluidic-analytical-method-based-on-simultaneous-uptake-and-derivatization-in-a-temperature-controlled-annular-flow
#16
Maud Guglielmino, Pierre Bernhardt, Claire Trocquet, Christophe A Serra, Stéphane Le Calvé
This paper is focused on the improvement of a microfluidic analytical method for the detection of low airborne formaldehyde concentrations, based on only two distinct steps permitting to reduce the response time and to improve the compactness of the device. First, gaseous formaldehyde is trapped into an acetylacetone solution at 65°C through an annular liquid/gas flow and reacts immediately to form 3,5-Diacetyl-1,4-dihydrolutidine which is then quantified by colorimetry using a liquid core waveguide (LCW)...
September 1, 2017: Talanta
https://www.readbyqxmd.com/read/28600563/multivariate-classification-of-echellograms-a-new-perspective-in-laser-induced-breakdown-spectroscopy-analysis
#17
Pavel Pořízka, Jakub Klus, Jan Mašek, Martin Rajnoha, David Prochazka, Pavlína Modlitbová, Jan Novotný, Radim Burget, Karel Novotný, Jozef Kaiser
In this work, we proposed a new data acquisition approach that significantly improves the repetition rates of Laser-Induced Breakdown Spectroscopy (LIBS) experiments, where high-end echelle spectrometers and intensified detectors are commonly used. The moderate repetition rates of recent LIBS systems are caused by the utilization of intensified detectors and their slow full frame (i.e. echellogram) readout speeds with consequent necessity for echellogram-to-1D spectrum conversion (intensity vs. wavelength)...
June 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28599495/investigation-of-the-relative-biological-effectiveness-and-uniform-isobiological-killing-effects-of-irradiation-with-a-clinical-carbon-sobp-beam-on-dna-repair-deficient-cho-cells
#18
Shigeaki Sunada, Ian M Cartwright, Hirokazu Hirakawa, Akira Fujimori, Mitsuru Uesaka, Takamitsu A Kato
Spread-out Bragg peak (SOBP) C ions have been used clinically in charged particle radiation therapy for years. An SOBP beam consists of various monoenergetic Bragg peaks; however, the biological effect of irradiation with an SOBP beam track has not been well-studied. In order to determine the clinically prospective molecular targets, radiosensitivity to the beam track in DNA repair deficient cell lines was investigated. A total of four distinct Chinese hamster ovary (CHO) cell lines, including CHO10B2 (wild-type), V3 (protein kinase DNA-activated catalytic polypeptide deficient), 51D1 (RAD51 paralog D deficient) and PADR9 [poly(ADP-ribose) polymerase (PARP) deficient], were irradiated with gamma-rays, C ions (290 MeV/n) and Fe ions (500 MeV/n), in order to compare cellular lethality...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28599372/a-hybrid-machine-learning-model-to-predict-and-visualize-nitrate-concentration-throughout-the-central-valley-aquifer-california-usa
#19
Katherine M Ransom, Bernard T Nolan, Jonathan A Traum, Claudia C Faunt, Andrew M Bell, Jo Ann M Gronberg, David C Wheeler, Celia Z Rosecrans, Bryant Jurgens, Gregory E Schwarz, Kenneth Belitz, Sandra M Eberts, George Kourakos, Thomas Harter
Intense demand for water in the Central Valley of California and related increases in groundwater nitrate concentration threaten the sustainability of the groundwater resource. To assess contamination risk in the region, we developed a hybrid, non-linear, machine learning model within a statistical learning framework to predict nitrate contamination of groundwater to depths of approximately 500m below ground surface. A database of 145 predictor variables representing well characteristics, historical and current field and landscape-scale nitrogen mass balances, historical and current land use, oxidation/reduction conditions, groundwater flow, climate, soil characteristics, depth to groundwater, and groundwater age were assigned to over 6000 private supply and public supply wells measured previously for nitrate and located throughout the study area...
June 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28598160/a-double-decarboxylation-in-superfolder-green-fluorescent-protein-leads-to-high-contrast-photoactivation
#20
Joshua D Slocum, Lauren J Webb
A photoactivatable variant of superfolder GFP (GFP) was created by replacing the threonine at position 203 with aspartic acid. Photoactivation by exposure of this mutant to UV light resulted in conversion of the fluorophore from the neutral to the negatively charged form, accompanied by a ~95-fold increase in fluorescence under 488 nm excitation. Mass spectrometry before and after exposure to UV light revealed a change in mass of 88 Da, attributed to the double decarboxylation of Glu 222 and Asp 203. Kinetics studies and non-linear power-dependence of the initial rate of photoconversion indicated that the double decarboxylation occurred via a multiphoton absorption process at 254 nm...
June 9, 2017: Journal of Physical Chemistry Letters
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