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Ying Huang, Jing Wen, Hong-Ying Li, Xu-Pai Zhang, Dong-Hong Deng, Peng Cheng, Zhi-Gang Peng, Wei-Hua Zhao, Jun Luo, Yuan Long, Zheng-Fang Liu
OBJECTIVE: To investigate the expression of miR-550a-5p in bone marrow of patients with myelodysplastic syndrome (MDS), and to predict its target genes and function by bioinformatics analyses, so as to provide the evidence to furthre explore the role of miR-550a-5p and its target genes in pathogenesis of MDS. METHODS: Real-time PCR was used to detect the expression of miR-550a-5p in 54 MDS patients, 16 acute myeloid leukemia transformed from MDS (sfAML) and 19 healthy controls, and the correlation between the expression of miR-550a-5p and clinical pathologic characteristics of MDS, including chromosome, percentage of marrow blasts, absolute neutrophil count, platelet count and hemoglobin levels were analyzed...
October 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
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