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Naohiro Yanagisawa, Naoyoshi Nagata, Kazuhiro Watanabe, Tatsuhiro Iida, Mariko Hamada, Sakurako Kobayashi, Takuro Shimbo, Junichi Akiyama, Naomi Uemura
AIM: To verify the validity of the endoscopy guidelines for patients taking warfarin or direct oral anticoagulants (DOAC). METHODS: We collected data from 218 patients receiving oral anticoagulants (73 DOAC users, 145 warfarin users) and 218 patients not receiving any antithrombotics (age- and sex-matched controls) who underwent polypectomy. (1) We evaluated post-polypectomy bleeding (PPB) risk in patients receiving warfarin or DOAC compared with controls; (2) we assessed the risks of PPB and thromboembolism between three AC management methods: Discontinuing AC with heparin bridge (HPB) (endoscopy guideline recommendation), continuing AC, and discontinuing AC without HPB...
April 14, 2018: World Journal of Gastroenterology: WJG
Midori A Arai, Ryuta Akamine, Anna Tsuchiya, Tatsuro Yoneyama, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibashi
Aberrant activation of Notch signaling contributes to the pathogenesis of several different types of cancer, and Notch pathway inhibitors may have significant therapeutic potential. Using a unique cell-based assay system, we isolated twelve compounds, including one new natural product from Garcinia speciosa, that inhibit the Notch signaling pathway. HES1 and HES5 are target genes of the Notch cascade, and compound 2, referred to as cowanin, decreased the protein levels of HES1 and HES5 in assay cells. Furthermore, cowanin (2) showed potent cytotoxicity against human leukemic HPB-ALL cells...
March 29, 2018: Scientific Reports
Brooke Vuong, Ahmed Dehal, Abhineet Uppal, Stacey L Stern, Juan Mejia, Roshanthi Weerasinghe, Vandana Kapoor, Evan Ong, Paul D Hansen, Anton J Bilchik
BACKGROUND: An initiative was established to improve value-based care for pancreatic surgery in a large non-profit health system. Cost data was presented bimonthly to a hepatobiliary (HPB) clinical performance group (CPG) via a videoconference. STUDY DESIGN: The direct costs were calculated for all patients undergoing distal pancreatectomy (DP) and pancreaticoduodenectomy (PD) between January 2014 and July 2017. Median length of stay (LOS), 30, 90-day mortality, readmission rate, and costs were stratified by surgeon volume, utilizing two published criteria: "Volume Pledge" criteria (≥5 PDs/year) and Leapfrog criteria (≥11 PDs/year)...
March 23, 2018: Journal of the American College of Surgeons
Qinyu Chen, Fabio Bagante, Katiuscha Merath, Jay Idrees, Eliza W Beal, Jordan Cloyd, Mary Dillhoff, Carl Schmidt, Adrian Diaz, Susan White, Timothy M Pawlik
BACKGROUND: The association of hospital teaching status and overall expenditures has not been studied among patients undergoing hepato-pancreato-biliary (HPB) surgery. We sought to define the impact of hospital teaching intensity on payments and charges associated with (HPB) surgery from the payer perspective. METHODS: Surgical patients undergoing HPB procedures were identified using 2013-2015 Medicare Provider Analysis and Review (MEDPAR) data. Hospital teaching intensity was categorized based on hospital resident-to-bed ratio: non-teaching (NTH: 0), minor teaching (minor-TH: 0-0...
March 21, 2018: World Journal of Surgery
M Mizandari, J Kumar, M Pai, T Chikovani, T Azrumelashvili, I Reccia, N Habib
Background: Malignant biliary and/or pancreatic obstruction has often encountered in the advanced stages of periampullary and cholangicarcinomas. HabibTM Radiofrequency (RF) ablation has been successfully used in the management of various cancers of liver and pancreas. Percutaneous HPB probe (EMcision Ltd, London, UK) is a new addition to this class of tools. It is an endoluminal Radiofrequency (RF) catheter which works on the principle of ablation and induces coagulative necrosis to recanalize the obstructed duct...
2018: Journal of Cancer
H Boyd-Carson, G Irving, A P Navarro, I C Cameron, D Gomez
AIM: To evaluate the impact of anti-platelet therapy on the outcomes of patients undergoing liver resection for CRLM. Secondary aim was to determine whether anti-platelet therapy influenced histo-pathological changes in CRLM. METHODS: Patients treated with liver resection for CRLM were identified from a prospectively maintained hepatobiliary database during an 11-year period. Collated data included demographics, primary tumour treatment, surgical data, histopathology analysis and clinical outcome...
March 16, 2018: International Journal of Surgery
Guor-Cheng Fang, Chao-Yang Huang, Yuan-Jie Zhuang, Wen-Chuan Huang, Kai-Hsiang Tsai, You-Fu Xiao
The ambient air particulates pollutants of total suspended particulates (TSP) and PM2.5 were collected by using PS-1 and Wilbur PM2.5 sampler, simultaneously during the year of 2015-2017 at a photoelectric factory in Science Park of central Taiwan. And those of the ambient air atmospheric metallic elements (Cr, Mn, Ni, Cu, Zn, Pb) concentrations which attached on the TSP and PM2.5 were analyzed by using inductively coupled plasma optical emission spectrometer. In addition, identifying anthropogenic and natural pollutants sources were conducted by using the enrichment factor (EF) and principal component analysis (PCA) methods...
March 16, 2018: Environmental Geochemistry and Health
Imran A Siddiqui, Amit V Sastry, John B Martinie, Dionisios Vrochides, Erin H Baker, David A Iannitti
BACKGROUND: Sixteen hepatopancreatobiliary fellowship programs in North America are accredited by the Fellowship Council. This study aims to assess fellows' perceptions of their training program. METHODS: A multiple-choice questionnaire was sent to 35 fellows to assess how they perceived their training: academics, research, operative experiences, autonomy, mentorship, program quality and weaknesses. The survey was developed using the SurveyMonkey® tool. RESULTS: Twenty-four of 35 fellows completed the survey...
March 7, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Elena Cutrín Gómez, Soledad Anguiano Igea, José Luis Gómez Amoza, Francisco J Otero Espinar
Soluble derivatives of β-cyclodextrin (CD) have a high capacity to solubilise hydrophobic molecules and to interact with proteins and membrane component. As consequence CD derivatives shows a significant activity as drug absorption enhancers through different delivery routes, such as the oral, nasal, ocular or topical route. In this paper, the effect of two CD derivatives -methyl-β-cyclodextrin (MBCD) and hydroxypropyl-β-cyclodextrin (HPB)- on the structure and permeability of the nail plate has been studied using the drug model ciclopirox olamine...
February 28, 2018: European Journal of Pharmaceutical Sciences
Eliza W Beal, Dmitry Tumin, Jeffery Chakedis, Erica Porter, Dimitrios Moris, Xu-Feng Zhang, Sherif Abdel-Misih, Mary Dillhoff, Andrei Manilchuk, Jordan Cloyd, Carl R Schmidt, Timothy M Pawlik
BACKGROUND: The objective of the current study was to define risk factors associated with the 30-day post-operative risk of VTE after HPB surgery and create a model to identify patients at highest risk of post-discharge VTE. METHODS: Patients who underwent hepatectomy or pancreatectomy in the ACS-NSQIP Participant Use Files 2011-2015 were identified. Logistic regression modeling was used; a model to predict post-discharge VTE was developed. Model discrimination was tested using area under the curve (AUC)...
February 19, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Margaret G Keane, Mayur Kumar, Natascha Cieplik, Douglas Thorburn, Gavin J Johnson, George J Webster, Michael H Chapman, Keith J Lindley, Stephen P Pereira
BACKGROUND: In adults ERCP and endoscopic ultrasound (EUS) are standard methods of evaluating and treating many hepatopancreaticobiliary (HPB) conditions. HPB disease is being diagnosed with increasing frequency in children but information about role of ERCP and EUS and their outcomes in this population remain limited. Therefore the aims of this study were to describe the paediatric ERCP and EUS experience from a large tertiary referral HPB centre, and to systematically compare outcomes with those of other published series...
February 9, 2018: BMC Pediatrics
Muthukumar Krishnan, Harinee Subramanian, Hans-Uwe Dahms, Vignesh Sivanandham, Palanichamy Seeni, Subramanian Gopalan, Ashok Mahalingam, Arthur James Rathinam
Turbinaria ornata (TO) extract was tested as green corrosion inhibitor on mild steel (MS) coupons in conc. HCl medium with an efficiency of 100% at 25 g l-1 during 5 min exposure. Antibacterial efficacy performed against 16 S rDNA identified marine biofilming bacteria (MBB) and human pathogenic bacteria (HPB). Maximum inhibition growth was 16 mm on MBB observed in Bacillus megaterium (MBF14 - AB894827) and 20 mm on HPB in Escherichia coli (B5 - NCIM 2931). Similarly, minimum of 10 mm on MBB witnessed in Pseudomonas sp...
February 8, 2018: Scientific Reports
Chengfei Huang, Ping Li, Xiao Kang Ma, Neil William Jaworski, Hans Henrik Stein, Chang Hua Lai, Jin Biao Zhao, Shuai Zhang
Objective: An experiment was conducted to investigate the effects of different diet formulations: F1 (Two complicated basal diets containing different CP levels plus tested feedstuff) vs F2 (A simple corn soybean meal basal diet plus tested feedstuff) combined with total collection (TC) or chromic oxide (Cr2O3) marker or acid-insoluble ash (AIA) marker method, and freeze-dry (FD) or oven-dry (OD) technique on estimation of nutrient digestibility in diets fed to growing pigs. Methods: In F1, twelve barrows were allocated to two 6 × 4 Youden Squares...
January 26, 2018: Asian-Australasian Journal of Animal Sciences
Bao-Li Fei, Jian-Kai Zhong, Ni-Ping Deng, Jiang-Hong Wang, Qing-Bo Liu, Yang-Guang Li, Xiang Mei
A environment-friendly 3D inorganic heteropoly blue (HPB) Ba2 Na2 [HPWV 4 WVI 8 O40 ]·26H2 O was directly synthesized by hydrothermal method and characterized by means of ICP, IR, XPS, X-ray single crystal and X-ray powder diffraction. It was an efficient heterogeneous photo-Fenton-like catalyst to degrade anionic dye methyl orange under visible light irradiation. It removed cationic dyes methylene blue in neutral environment and rhodamine B in acidic condition via flocculation. The removal efficiency of methylene blue and rhodamine B by flocculation was more than 95%...
April 2018: Chemosphere
Bertrand Le Roy, Emilie Grégoire, Cyril Cossé, Badr Serji, Nicolas Golse, René Adam, Daniel Cherqui, Jean-Yves Mabrut, Yves-Patrice Le Treut, Eric Vibert
BACKGROUND: ICGR15 is widely used in Asia to evaluate the liver reserve before hepatectomy, but not in Western countries where patients are selected using the MELD score and/or platelet count. Postoperative liver failure is rare nowadays, but hepatic decompensation (HD), defined by 3-month postoperative ascites, impairs quality of life and survival. The aim of this study was to evaluate the relevance of indocyanine green retention rate at 15 min (ICGR15) before liver resection in Western countries, in order to predict HD...
January 16, 2018: World Journal of Surgery
David J Breen
David J Breen is Associate Professor of Radiology and previous Clinical Director of Radiology at University Hospital Southampton. His interests are in abdominal imaging and intervention, particularly of hepato-pancreato-biliary (HPB)and renal disease. He has a major interest in image-guided tumor ablation and improving outcomes from these procedures. He has previously served as Vice Chair of the NHS England Clinical Reference Group in Interventional Radiology and for the NIHR/NCRN Upper GI Clinical Studies Group...
February 2018: Biomarkers in Medicine
Siu Yin Lee, Soo-Hoon Lee, Jenny H H Tan, Howard S L Foo, Phillip H Phan, Alfred W C Kow, Sein Lwin, Penelope M Y Seah, Siti Zubaidah Mordiffi
BACKGROUND: Patients with prolonged length of hospital stay (LOS) not only increase their risks of nosocomial infections but also deny other patients access to inpatient care. Hepatobiliary (HPB) malignancies have some of highest incidences in East and Southeast Asia and the management of patients undergoing HPB surgeries have yet to be standardized. With improved neurosurgery techniques for intracranial aneurysms and tumors, neurosurgeries (NS) can be expected to increase. Elective surgeries account for far more operations than emergencies surgeries...
January 5, 2018: BMC Health Services Research
Alessia Arelli, Andrea Nuzzo, Claudia Sabia, Ibrahim M Banat, Giulio Zanaroli, Fabio Fava
Washing is a rapid and effective treatment to remediate contaminated sands impacted by oil spills, although synthetic additives used to increase extraction efficiency may cause additional pollution issues due to their intrinsic toxicity and very often low biodegradability. In this study, different biogenic mobilizing agents (soybean lecithins, cyclodextrins, cholic acids, plant-derived cleaners, rhamnolipids and sophorolipids) were tested in the washing of beach sands artificially contaminated with the Intermediate Fuel Oil IFO-180...
July 25, 2018: New Biotechnology
Asma Sultana, Mark Brooke-Smith, Shahid Ullah, Joan Figueras, Myrddin Rees, Jean-Nicolas Vauthey, Claudius Conrad, Thomas J Hugh, O James Garden, Sheung T Fan, Michael Crawford, Masatoshi Makuuchi, Yukihiro Yokoyama, Markus Büchler, Robert Padbury
BACKGROUND: The International Study Group for Liver Surgery (ISGLS) definition of post hepatectomy liver failure (PHLF) was developed to be consistent, widely applicable, and to include severity stratification. This international multicentre collaborative study aimed to prospectively validate the ISGLS definition of PHLF. METHODS: 11 HPB centres from 7 countries developed a standardised reporting form. Prospectively acquired anonymised data on liver resections performed between 01 July 2010 and 30 June 2011 was collected...
December 26, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Jake Jk Goh
BACKGROUND: Since 2016, the Naval Diving Unit (NDU) of the Republic of Singapore Navy (RSN) has instituted a smoking cessation trial program for their trainees, instituting a blanket ban on smoking during training hours in order to promote smoking cessation and create a smoke-free culture among its servicemen. For the rest of RSN personnel, they would attend a more costly, established Health Promotion Board (HPB) smoking cessation program, which employs social support strategies, while they undergo basic training in the Navy Military Experts Institute (NMI)...
November 2017: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
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