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https://www.readbyqxmd.com/read/27905087/robot-assisted-surgery-in-elderly-and-very-elderly-population-our-experience-in-oncologic-and-general-surgery-with-literature-review
#1
Graziano Ceccarelli, Enrico Andolfi, Alessia Biancafarina, Aldo Rocca, Maurizio Amato, Marco Milone, Marta Scricciolo, Barbara Frezza, Egidio Miranda, Marco De Prizio, Andrea Fontani
BACKGROUND: Although there is no agreement on a definition of elderly, commonly an age cutoff of ≥65 or 75 years is used. Nowadays most of malignancies requiring surgical treatment are diagnosed in old population. Comorbidities and frailty represent well-known problems during and after surgery in elderly patients. Minimally invasive surgery offers earlier postoperative mobilization, less blood loss, lower morbidity as well as reduction in hospital stay and as such represents an interesting and validated option for elderly population...
November 30, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27894845/thromboelastography-demonstrates-perioperative-hypercoagulability-in-hepato-pancreato-biliary-patients-and-supports-routine-administration-of-preoperative-and-early-postoperative-venous-thromboembolism-chemoprophylaxis
#2
Anh-Thu Le, Jennifer W Harris, Erin Maynard, Sean P Dineen, Ching-Wei D Tzeng
BACKGROUND: We hypothesized hepato-pancreato-biliary (HPB) surgery patients are more likely to be hypercoagulable than hypocoagulable, and that bleeding risks from VTE chemoprophylaxis are low. This study sought to use thromboelastography (TEG) to compare coagulation profiles with bleeding/thrombotic events in HPB patients receiving standardized perioperative chemoprophylaxis. METHODS: Consecutive patients undergoing HPB resections by three surgeons at one institution (January 2014-December 2015) received preoperative and early postoperative VTE chemoprophylaxis and were evaluated with TEGs...
November 25, 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/27892974/dimalononitrile-containing-probe-based-on-aggregation-enhanced-emission-features-for-the-multi-mode-fluorescence-detection-of-volatile-amines
#3
Lingwei Kong, Yahui Zhang, Huiling Mao, Xiaoling Pan, Yong Tian, Zhonglin Tian, Xiangkai Zeng, Jianbing Shi, Bin Tong, Yuping Dong
A novel multi-mode probe consisting of a hexaphenyl-1,3-butadiene derivative, 2,2'-((((1Z,3Z)-1,2,3,4-tetraphenylbuta-1,3-diene-1,4-diyl)bis(4,1-phenylene))bis(methanylylidene))dimalononitrile (ZZ-HPB-CN), with typical aggregation-enhanced emission (AEE) features was easily prepared for the highly sensitive and rapid detection of amine vapors. The ZZ-HPB-CN sensor, which was prepared by simply depositing ZZ-HPB-CN on filter paper, could detect low concentration vapors of volatile amines using fluorescence, ultraviolet and naked-eye detection...
November 28, 2016: Faraday Discussions
https://www.readbyqxmd.com/read/27884545/a-survey-of-current-practices-and-barriers-to-expanding-laparoscopic-hpb-surgery-in-canada
#4
Ricky Jrearz, Anand Govindarajan, Shiva Jayaraman
BACKGROUND: The purpose of this survey was to determine the extent to which laparoscopy is used in hepatopancreatobiliary (HPB) resections in Canada, and to assess HPB surgeons' attitudes and their perceived barriers to its further adoption. METHODS: Using an electronic questionnaire, 68 Canadian Hepatopancreatobiliary Association (CHPBA) surgical members were surveyed. The questionnaire consisted of 12 questions regarding: surgeon demographics, the use and limitations of laparoscopy in their practice, and interest in increasing the use of laparoscopic techniques...
November 21, 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/27835033/travel-distance-to-prenatal-care-and-high-blood-pressure-during-pregnancy
#5
Lu Shi, Kara E MacLeod, Donglan Zhang, Fan Wang, Margaret Shin Chao
OBJECTIVE: To assess whether poor geographic accessibility to prenatal care, as indicated by long distance trips to prenatal care, produced high blood pressure (HPB) during pregnancy. METHODS: Using the 2007 Los Angeles Mommy and Baby Study for women without hypertension prior to pregnancy (n = 3405), we compared self-reported HBP by travel distance to prenatal care controlling for age, race/ethnicity, marital status, education, household income, weight status, and physical activity...
November 11, 2016: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/27815743/presence-of-a-fellowship-improves-perioperative-outcomes-following-hepatopancreatobiliary-procedures
#6
Maria S Altieri, Jie Yang, Donglei Yin, Catherine Frenkel, Mark Talamini, Dana A Telem, Aurora Pryor
INTRODUCTION: There is an increase in subspecialization and in the number of surgeons seeking fellowship training in the USA. Little is known regarding the effect of hepatopancreatobiliary (HPB) fellowship programs' status of an institution on perioperative outcomes. This study aims to examine the effect of such status on perioperative outcomes across all institutions following complex surgeries involving HPB procedures in the State of New York (NYS). METHODS: The Statewide Planning and Research Cooperative System administrative database was used to identify several complex surgeries involving the pancreas, liver, and gallbladder by using ICD-9 codes for inpatient procedures between 2012 and 2014...
November 4, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27806836/classification-and-techniques-of-en-bloc-venous-reconstruction-for-pancreaticoduodenectomy
#7
Farzad Alemi, Flavio G Rocha, William S Helton, Thomas Biehl, Adnan Alseidi
BACKGROUND: Surgical resection is the only cure for hepatopancreatobiliary (HPB) malignancy. In the era of multidisciplinary approaches and neoadjuvant therapies for locally advanced, borderline resectable tumors, the feasibility and efficacy of en bloc vascular resection has been validated across multiple studies. However, the variability of venous anatomy within the perihepatic and peri-portal regions necessitates familiarity with alternative resection and reconstruction techniques appropriate to the specific region of tumor invasion...
October 30, 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/27806030/a-morbidity-mortality-analysis-of-a-tertiary-level-upper-gastrointestinal-hepatopancreaticobiliary-surgical-unit
#8
Susrutha K Wickremesekera, Ho Beom Sean Seo, Mary Anne Trimber, Simon Bann, Katherine Tse
: Internationally, regionalisation of major upper gastrointestinal/hepatopancreaticobiliary (UGI/HPB) surgery to a selected number of expert hospital centres has demonstrated that high hospital volume is associated with lower mortality and morbidity. The Wellington UGI/HPB unit compared to international institutions is a low volume unit, however within New Zealand we perform a high number of Upper GI/HPB cases. AIMS: The aim of this study was to evaluate the quality measures of morbidity and mortality of major upper gastrointestinal and hepatopancreatobiliary surgeries performed at the Wellington UGI/HPB unit...
October 28, 2016: New Zealand Medical Journal
https://www.readbyqxmd.com/read/27770492/the-need-for-organization-of-laparoscopic-liver-resection
#9
Daniel Cherqui, Go Wakabayashi, David A Geller, Joseph F Buell, Ho-Seong Han, Olivier Soubrane, Nicholas O'Rourke
In this article, we present the rationale for creating a new society aiming at organizing laparoscopic liver surgery. It has been named International Laparoscopic Liver Society (ILLS). Its main mission is to facilitate the diffusion and education of laparoscopic liver resection for meaningful improvements in patient care. This will include organization of a biannual congress dedicated to laparoscopic liver resection, coordination of international registries, helping in the education of surgeons wishing to learn these techniques including travel grants, provide a website serving as a forum supporting collaboration between surgeons interested in the advancement of laparoscopic liver resection techniques (http://www...
October 21, 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/27766758/training-in-hepato-pancreato-biliary-surgery-during-residency-past-present-and-future-perspectives
#10
REVIEW
Martin de Santibañes, Eduardo de Santibañes, Juan Pekolj
The paradigm introduced by William Halsted for surgical residency training has been considered the most appropriate educational system to acquire the knowledge and surgical skills required to become a competent general surgeon. Hepato-pancreato-biliary (HPB) surgery is considered an important part of general surgery training because of its high prevalence and complexity. Nowadays, we are faced with a worldwide shortage of general surgeons candidates, restrictive working hours and less surgical exposure, situations that can undermine the objectives of training in HPB surgery during residency...
December 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/27747332/carbon-rich-click-1-2-3-triazoles-hexaphenylbenzene-and-hexa-peri-hexabenzocoronene-based-ligands-for-suzuki-miyaura-catalysts
#11
James R Wright, James D Crowley, Nigel T Lucas
Hexaphenylbenzene (HPB) and hexa-peri-hexabenzocoronene-(HBC) functionalised 1,2,3-triazoles have been synthesised using an optimised copper(i)-catalysed azide-alkyne cycloaddition (CuAAC) reaction. The coordination chemistry of these ligands was explored through the synthesis of the respective palladium(ii) complexes and their activity as catalysts in the Suzuki-Miyaura reaction assessed.
October 17, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27746036/perception-of-training-in-hepatopancreatobiliary-surgery-among-general-surgery-residents-in-the-americas
#12
Mohd Raashid Sheikh, Houssam Osman, Muhammad Umar Butt, Dhiresh Rohan Jeyarajah
BACKGROUND: Hepatopancreatobiliary (HPB) surgery experience during residency in the Americas is limited. Residents interested in HPB surgery have different options available for further training. This study evaluated training in HPB surgery received during general surgery (GS) residency, and sought to determine the perception of fellowship training in HPB surgery. METHODS: An anonymous survey was distributed to all 259 GS residency programs in the United States...
October 13, 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/27696209/impact-of-delta-hemoglobin-on-provider-transfusion-practices-and-post-operative-morbidity-among-patients-undergoing-liver-and-pancreatic-surgery
#13
Gaya Spolverato, Fabio Bagante, Matthew Weiss, Jin He, Christopher L Wolfgang, Fabian Johnston, Martin A Makary, Will Yang, Steven M Frank, Timothy M Pawlik
BACKGROUND: Delta hemoglobin (ΔHb) is defined as the difference between the preoperative Hb and the lowest post-operative Hb level. We sought to define the impact of ΔHb relative to nadir Hb levels on the likelihood of transfusion, as well as characterize the impact of ΔHb and nadir Hb on morbidity among a large cohort of patients undergoing complex hepatopancreatobiliary (HPB) surgery. METHODS: Patients who underwent pancreatic or hepatic resection between January 1, 2009 and June 30, 2015 at Johns Hopkins Hospital were identified...
September 30, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27618873/optimized-liquid-chromatography-nanoelectrospray-high-resolution-tandem-mass-spectrometry-method-for-the-analysis-of-4-hydroxy-1-3-pyridyl-1-butanone-releasing-dna-adducts-in-human-oral-cells
#14
Bin Ma, Chris Ruszczak, Vipin Jain, Samir S Khariwala, Bruce Lindgren, Dorothy K Hatsukami, Irina Stepanov
Metabolic activation of the carcinogenic tobacco-specific N-nitrosamines leads to the formation of 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB)-releasing DNA adducts. We recently developed a liquid chromatography (LC)-tandem mass spectrometry (MS/MS) method for the analysis of HPB-releasing DNA adducts in human oral cells. However, given the limited amounts of DNA that can be extracted from oral cells, higher sensitivity and selectivity are required for the reliable analysis of these adducts in future studies. We have developed a new sensitive LC-nanoelectrospray ionization-high-resolution MS/MS method for the analysis of HPB-releasing DNA adducts in oral cells...
October 12, 2016: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27598571/reducing-antibiotic-resistance-genes-integrons-and-pathogens-in-dairy-manure-by-continuous-thermophilic-composting
#15
Xun Qian, Wei Sun, Jie Gu, Xiao-Juan Wang, Ya-Jun Zhang, Man-Li Duan, Hai-Chao Li, Ran-Ran Zhang
This study explored the effects of composting using three temperature regimes, namely, insufficient thermophilic composting (ITC), normal thermophilic composting (NTC), and continuous thermophilic composting (CTC), on antibiotic resistance genes (ARGs), integrons, and human pathogenic bacteria (HPB), as well as the mechanisms involved. The NTC and CTC treatments led to greater decreases in 5/10 ARGs and two integrons than ITC, and the abundances of ARGs (tetC, tetG, and tetQ) and int1 only declined in the NTC and CTC treatments...
November 2016: Bioresource Technology
https://www.readbyqxmd.com/read/27593592/european-experience-of-573-liver-resections-for-hepatocellular-adenoma-a-cross-sectional-study-by-the-afc-hca-2013-study-group
#16
Alexis Laurent, Safi Dokmak, Jean-Charles Nault, François-René Pruvot, Jean-Michel Fabre, Christian Letoublon, Philippe Bachellier, Lorenzo Capussotti, Olivier Farges, Jean-Yves Mabrut, Yves-Patrice Le Treut, Ahmet Ayav, Bertrand Suc, Olivier Soubrane, Gilles Mentha, Irinel Popescu, Marco Montorsi, Nicolas Demartines, Jacques Belghiti, Guido Torzilli, Daniel Cherqui, Jean Hardwigsen
BACKGROUND: Hepatocellular adenoma (HCA) is a benign hepatic lesion that may be complicated by bleeding and malignant transformation. The aim of the present study is to report on large series of liver resections for HCA and assess the incidence of hemorrhage and malignant transformation. METHODS: A retrospective cross-sectional study, from 27 European high-volume HPB units. RESULTS: 573 patients were analyzed. The female: male gender ratio was 8:2, mean age: 37 ± 10 years...
September 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/27585922/surgical-treatment-of-hepato-pancreato-biliary-disease-in-china-the-tongji-experience
#17
Binhao Zhang, Wei Dong, Hongping Luo, Xuanru Zhu, Lin Chen, Changhai Li, Peng Zhu, Wei Zhang, Shuai Xiang, Wanguang Zhang, Zhiyong Huang, Xiao-Ping Chen
Hepato-pancreato-biliary (HPB) tumors are common in China. However, these tumors are often diagnosed at intermediate/ advanced stages because of the lack of a systemic surveillance program in China. This situation creates many technical challenges for surgeons and increases the incidence of postoperative complications. Therefore, Dr. Xiao-Ping Chen has made many important technical improvements, such as Chen's hepatic portal occlusion method, the anterior approach for liver resection of large HCC tumors, the modified technique of Belghiti's liver-hanging maneuver, inserting biliary-enteric anastomosis technique, and invaginated pancreaticojujunostomy with transpancreatic U-sutures...
October 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27567546/in%C3%A2-vitro-metabolism-of-n-nitrosonornicotine-catalyzed-by-cytochrome-p450-2a13-and-its-inhibition-by-nicotine-n-nitrosoanatabine-and-n-nitrosoanabasine
#18
Xingyu Liu, Jie Zhang, Limeng Wang, Bicheng Yang, Chen Zhang, Wei Liu, Jun Zhou
N'-Nitrosonornicotine (NNN) is considered to be one of the most carcinogenic compounds of the four conventionally measured tobacco-specific N-nitrosamines (TSNAs). In order to evaluate the significance of metabolic activation for the carcinogenic potential of NNN, its catalysis by different phase I enzymes and its interaction with nicotine and nicotine-derived TSNAs need to be investigated. Using an in vitro model system, NNN was found to interact with various cytochrome P450 enzymes, predominantly CYP2A13...
August 25, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27546012/objective-assessment-of-trainee-operative-experience-in-a-tertiary-hepatobiliary-unit
#19
H M Joshi, E Alabraba, A Tufo, A Zone, P Ghaneh, S W Fenwick, G J Poston, H Z Malik
INTRODUCTION: Indicative numbers for completion of training (CCT) in the UK requires 35 upper Gastrointestinal/Hepatobiliary resections and 110 (50 non HPB trainees) cholecystectomies. We aim to identify whether the training experience in our centre meets the CCT requirements for hepatobiliary surgery and compare training opportunities to those in international fellowships. METHODS: We retrospectively reviewed our hospital's operating theatre database for all patients undergoing a liver or gallbladder resection between January 2008 and July 2015 using corresponding procedural codes and consultant name...
October 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27541973/the-practice-of-laparoscopic-liver-surgery-in-belgium-a-national-survey
#20
Federico Tomassini, Vincenzo Scuderi, Giammauro Berardi, Alexandra Dili, Mathieu D'Hondt, Gregory Sergeant, Catherine Hubert, Frederik Huysentruyt, Frederik Berrevoet, Valerio Lucidi, Roberto Ivan Troisi
BACKGROUND: Laparoscopic liver surgery (LLS) gained popularity bringing several advantages including decreased morbidity and reduction of length of hospital stay compared to open. METHODS: To understand practice and evolution of LLS in Belgium, a 20-questions survey was sent to all members of the Royal Belgian Society for Surgery, the Belgian Section of Hepato-Pancreatic and Biliary Surgery and the Belgian Group for Endoscopic Surgery. RESULTS: Thirty-seven surgical units representing 61 surgeons performing LLS in Belgium responded: 50% from regional hospitals, 28% from university and 22% from peripheral hospitals...
August 19, 2016: Acta Chirurgica Belgica
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