keyword
https://read.qxmd.com/read/33451815/hepatic-elastometry-and-glissonian-line-in-the-assessment-of-liver-fibrosis
#21
JOURNAL ARTICLE
Paolo Borro, Sebastiano Ziola, Andrea Pasta, Marco Trombini, Sara Labanca, Simona Marenco, David Solarna, Livia Pisciotta, Isabella Baldissarro, Antonino Picciotto, Silvana Dellepiane
The aim of this study was to identify a method for staging hepatic fibrosis using a non-invasive, rapid and inexpensive technique based on ultrasound morphologic hepatic features. A total of 215 patients with different liver diseases underwent B-mode (2-D brightness mode) ultrasonography, vibration-controlled transient elastography, 2-D shear wave elastography and measurement of the controlled attenuation parameter with transient elastography. B-Mode images of the anterior margin of the left lobe were obtained and processed with automatic Genoa Line Quantification (GLQ) software based on a neural network for staging liver fibrosis...
April 2021: Ultrasound in Medicine & Biology
https://read.qxmd.com/read/33346465/-non-alcoholic-fatty-liver-disease-and-type-2-diabetes-mellitus-issues-of-the-liver-fibrosis-diagnostics
#22
JOURNAL ARTICLE
A V Anisonyan, Y G Sandler, T Y Khaimenova, V A Keyan, K G Saliev, E S Sbikina, E V Vinnitskaya
AIM: To evaluate the frequency of liver fibrosis progression to stage 34 among patients with non-alcoholic fatty liver disease (NAFLD), type 2 diabetes and obesity, to identify predictors of severe liver fibrosis, to propose an algorithm for diagnosing fibrosis in this category of patients. MATERIALS AND METHODS: 160 patients with NAFLD, type 2 diabetes mellitus (DM) and obesity and 50 patients with NAFLD without diabetes were comprehensively examined. Patients underwent laboratory examination (clinical blood test, biochemical analysis, immunoglobulins G, M, autoantibody assay, coagulogram), liver ultrasound...
September 3, 2020: Terapevticheskiĭ Arkhiv
https://read.qxmd.com/read/33346459/-clinical-features-of-the-comorbid-course-of-non-alcoholic-fatty-liver-disease-and-gallstone-disease
#23
JOURNAL ARTICLE
N A Cherkashchenko, M A Livzan, T S Krolevets
AIM: To determine the diagnostic value of clinical features of the comorbid course of non-alcoholic fatty liver disease (NAFLD) and gallstone disease (GD) to improve the effectiveness of patient management. MATERIALS AND METHODS: 183 patients with NAFLD were included into the open comparative study. The main group was represented by patients with NAFLD and GD (n=88), of which 53 patients underwent cholecystectomy (CE). The comparison group was represented by patients with NAFLD without GD (n=95)...
September 3, 2020: Terapevticheskiĭ Arkhiv
https://read.qxmd.com/read/32711035/liver-elastometry-and-alcohol-withdrawal-median-term-follow-up-in-a-psychiatric-unit
#24
JOURNAL ARTICLE
Paul Carrier, Murielle Girard, Marilyne Debette-Gratien, Natacha Ouedraogo, Véronique Loustaud-Ratti, Philippe Nubukpo
The measurement of liver stiffness (LS) show promise as a follow-up tool after alcohol withdrawal but has mainly been studied in the early phase or in patients with severe liver disease. A six-month ancillary study of a specific psychiatric cohort of alcoholic patients without known liver disease followed after withdrawal was conducted (Clinical Trial NCT01491347). Clinical and biological data and LS values were collected every two months. A total of 129 patients were included in the study, 93 had a LS assessment within the first seven days and 37 had all four LS measurements...
July 22, 2020: Alcohol
https://read.qxmd.com/read/31863679/effect-of-liver-disease-on-post-therapeutic-complications-of-head-and-neck-squamous-cell-carcinoma-a-prospective-study-of-94-patients
#25
JOURNAL ARTICLE
Maxime Baert, Caroline Pascual, Vincent Hautefeuille, Eric Nguyen-Khac, Cyril Page
The principal risk factors for the development of Head &Neck Squamous Cell Carcinoma (HNSCC) are chronic alcohol and/or tobacco consumption. The evaluation of patient comorbidities is critical in the assessment of contraindications to usual treatment modalities, particularly for surgery. Most chronic liver diseases are usually asymptomatic until cirrhosis occurs with clinical decompensation. In this series, hepatic elastometry was higher in patients who had post therapeutic complications versus patients who had no complications...
December 21, 2019: Clinical Otolaryngology
https://read.qxmd.com/read/31610584/a-2-step-fast-track-elastometry-service-for-advanced-workup-of-nonalcoholic-fatty-liver-disease-nafld-patients-single-center-real-world-experience-of-outpatient-clinical-practice
#26
JOURNAL ARTICLE
Mohamed Alsenbesy, Monika Rau, Johannes Weiss, Oliver Götze, Andreas Geier
INTRODUCTION AND AIMS:  Nonalcoholic fatty liver disease (NAFLD) is increasing globally with an estimated prevalence of approximately 25 %. Nonalcoholic steatohepatitis as the progressive disease entity often leads to fibrosis and end-stage disease. The magnitude of NAFLD patients are not diagnosed and have no access to further clinical assessment. Diagnostic pathways for individual risk evaluation fitting with available resources are of utmost importance in real-world clinical practice...
October 2019: Zeitschrift Für Gastroenterologie
https://read.qxmd.com/read/31564109/association-between-visceral-abdominal-fat-accumulation-and-severity-of-liver-fibrosis-in-nondiabetic-individuals-coinfected-by-hiv-and-hcv
#27
JOURNAL ARTICLE
Laura Soldevila, Montserrat Tenesa, Judith Horneros, Jordi Bechini, Juan Jose Lopez, Ricardo Pérez, Miguel Angel Martinez, Dan Ouchi, Sandra Franco, Núria Pérez-Álvarez, Daniela Buccione, Bonaventura Clotet, Cristina Tural
Our primary objective was to assess the independent association between Liver fibrosis (LF) and Abdominal fat accumulation (AFA) and Fatty liver disease (FLD). We also aimed to determine the diagnostic accuracy of AFA and FLD for the prediction of cirrhosis measured using unenhanced low-dose computed tomography (CT). METHODS: Cross-sectional study in stable HIV/HCV-coinfected patients with active HCV replication. CT was used to quantify fat content in segments III and VI of the liver and AFA...
September 30, 2019: AIDS Research and Human Retroviruses
https://read.qxmd.com/read/30972854/effectiveness-and-safety-of-sofosbuvir-based-therapy-against-chronic-hepatitis-c-infection-after-successful-kidney-transplantation
#28
JOURNAL ARTICLE
Joanna Musialik, Aureliusz Kolonko, Katarzyna Kwiecień, Aleksander J Owczarek, Andrzej Więcek
BACKGROUND: Direct-acting antivirals (DAAs), including sofosbuvir (SOF), are recommended for treatment of chronic hepatitis C virus (HCV) infection. However, few studies have investigated the effectiveness and safety of new DAAs in kidney transplant recipients (KTRs). OBJECTIVES: To assess the effectiveness and safety of SOF-based therapy in stable KTRs. PATIENTS AND METHODS: Forty KTRs were treated with SOF-based regimens. Rapid, end-therapeutic, and sustained virologic responses were assessed, as was liver stiffness by elastometry...
June 2019: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/30612958/assessment-of-liver-fibrosis-by-transient-elastography-fibroscan-%C3%A2-in-patients-with-a1at-deficiency
#29
JOURNAL ARTICLE
Olivier Guillaud, Jérôme Dumortier, Julie Traclet, Lioara Restier, Philippe Joly, Colette Chapuis-Cellier, Alain Lachaux, Jean François Mornex
BACKGROUND: Alpha-1-antitrypsin deficiency (A1ATD) is a common genetic condition which predisposes to emphysema and liver disorders. It is estimated that 10-15% of homozygous individuals for the Z allele (PiZZ) may develop liver fibrosis. The optimal modalities to detect liver disease in PiZZ adult patients need to be defined. The aim of this prospective study was to perform a systematic non-invasive evaluation of the liver fibrosis by elastometry using Fibroscan® in a cohort of A1ATD patients with emphysema...
February 2019: Clinics and Research in Hepatology and Gastroenterology
https://read.qxmd.com/read/30304261/hepatitis-b-and-asymptomatic-malaria-coinfection-in-sub-saharan-african-immigrants-epidemiological-and-clinical-features-of-hbv-infection
#30
COMPARATIVE STUDY
Gaetano Scotto, Vincenzina Fazio
INTRODUCTION: Here, we conducted an epidemiological study of hepatitis B virus (HBV) mono-infected and asymptomatic malaria/HBV coinfected immigrants and further discussed the possibility of malaria disease modifying the clinical presentation of HBV infection. METHODS: A total of 195 African immigrants were examined for HBV infection or coinfection with HBV and asymptomatic malaria. HBV infection was diagnosed using serological tests and confirmed by PCR; furthermore, we performed a pan-Plasmodium-specific-nucleic-acid-sequence-based-amplification (NASBA) assay to detect asymptomatic malaria infection...
September 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://read.qxmd.com/read/29847179/epidemiological-demographic-and-clinical-data-on-chronic-viral-hepatitis-c-in-tuscany
#31
JOURNAL ARTICLE
Cristina Stasi, Caterina Silvestri, Roberto Berni, Maurizia Rossana Brunetto, Anna Linda Zignego, Cristina Orsini, Stefano Milani, Liana Ricciardi, Andrea De Luca, Pierluigi Blanc, Cesira Nencioni, Donatella Aquilini, Alessandro Bartoloni, Giampaolo Bresci, Santino Marchi, Franco Filipponi, Piero Colombatto, Paolo Forte, Andrea Galli, Sauro Luchi, Silvia Chigiotti, Alessandro Nerli, Giampaolo Corti, Rodolfo Sacco, Paola Carrai, Angelo Ricchiuti, Massimo Giusti, Paolo Almi, Andrea Cozzi, Silvia Carloppi, Giacomo Laffi, Fabio Voller, Francesco Cipriani
BACKGROUND: Recent introduction of direct antiviral agents (DAAs) has completely changed the scenario regarding hepatitis C virus (HCV) treatment. Certain countries' economic health programs prioritize DAAs according to specific clinical features of HCV-infected patients. The aim of this study was to define epidemiological, demographic and clinical characteristics of HCV-infected patients in the Tuscany region of central Italy. METHODS: We enrolled HCV patients with chronic viral hepatitis who were referred to the outpatient services of 16 hospitals in Tuscany from 1 January 2015 to 31 December 2015...
April 2019: Current Medical Research and Opinion
https://read.qxmd.com/read/28870440/the-noninvasive-diagnosis-of-esophageal-varices-and-its-application-in-clinical-practice
#32
REVIEW
Etienne Pateu, Frédéric Oberti, Paul Calès
Here, we review recent improvements made to different noninvasive tests used for the diagnosis of esophageal varices (EV) in the light of the recent Baveno VI recommendation and with an emphasis on clinical application. Like for fibrosis tests, these noninvasive EV tests can be classified as direct markers when they provide a visualization of EV (including all imaging procedures like endoscopy or radiology) and as indirect markers when they do not (blood markers or elastometry). Clinical descriptors expressed as percentages, especially the spared endoscopy rate and the missed high-risk esophageal varices (HREV) rate, are more eloquent in this setting than classical statistical descriptors like accuracy...
February 2018: Clinics and Research in Hepatology and Gastroenterology
https://read.qxmd.com/read/28573088/matrix-metalloproteases-and-their-tissue-inhibitors-in-non-alcoholic-liver-fibrosis-of-human-immunodeficiency-virus-infected-patients
#33
JOURNAL ARTICLE
Julio Collazos, Eulalia Valle-Garay, Tomás Suárez-Zarracina, Angel-Hugo Montes, José A Cartón, Víctor Asensi
AIM: To investigate the relationships among diverse metalloproteases (MMPs) and their tissue inhibitors (TIMPs) and non-alcoholic liver fibrosis in human immunodeficiency virus (HIV)-infected patients. METHODS: Single nucleotide polymorphisms (SNPs) in MMPs, TNF-α and CCR5 genes, and serum levels of MMPs and TIMPs were determined in HIV-infected individuals with/out hepatitis C virus (HCV) coinfection. A total of 158 patients were included, 57 of whom were HCV-coinfected...
May 12, 2017: World Journal of Virology
https://read.qxmd.com/read/27801373/comparative-assessment-of-liver-fibrosis-in-patients-with-hiv-chronic-hepatitis-c-co-infection-in-different-ethnic-groups
#34
COMPARATIVE STUDY
Nazgul Sarsekeyeva, Bakhyt Kosherova, Ilya Azizov
INTRODUCTION: In recent years, the frequency of human immunodeficiency virus (HIV) and hepatitis C (HCV) co-infection has increased, which is due to their common routes of transmission. HIV/chronic HCV co-infection aggravates the development of fibrosis and increases the risk of cirrhosis. The aim of the study was to evaluate the results of liver elastometry in patients of different ethnic groups with HIV/chronic HCV co-infection. METHODOLOGY: The study involved 49 Kazakh and 46 Russian patients with HIV/chronic HCV co-infection...
October 31, 2016: Journal of Infection in Developing Countries
https://read.qxmd.com/read/27271956/distribution-of-il28b-polymorphism-in-a-cohort-of-italians-and-immigrants-with-hcv-infection-association-with-viraemia-stage-of-fibrosis-and-response-to-treatment
#35
JOURNAL ARTICLE
L Nosotti, A Petrelli, D Genovese, S Catone, C Argentini, S Vella, A Rossi, G Costanzo, A Fortino, L Chessa, L Miglioresi, C Mirisola
Aims of the study are to investigate, in a cohort of patients affected by HCV chronic hepatitis with genotypes 1 and 4, the prevalence of interleukin 28B (IL28B) genotypes, the possible association between IL28B polymorphism and severity of liver damage, the role of IL28B CC as a predictor of outcome. 365 patients with HCV infection were observed between 2013 and 2014. Demographic, virological, biochemical, and genetic characteristics of each patient were investigated. Liver fibrosis was assessed by transient elastometry...
August 2017: Journal of Immigrant and Minority Health
https://read.qxmd.com/read/27070167/-the-efficiency-and-safety-of-anti-helicobacter-pylori-therapy-in-patients-with-concomitant-chronic-hepatitis-c
#36
JOURNAL ARTICLE
D N Andreev, I V Maev, Yu A Kucheryavyi, D T Dicheva, E V Partsvania-Vinogradova
AIM: To evaluate the efficiency and safety of two eradication therapy (ET) regimens for Helicobacter pylori infection in patients with concomitant chronic hepatitis C (CHC) in relation to the stage of liver fibrosis (LF). MATERIALS AND METHODS: A prospective clinical trial was conducted in parallel groups. Group 1 included 50 HCV-negative patients with H. pylori-associated peptic ulcer of the stomach or duodenum; Group 2 consisted of 50 HCV-positive patients with H...
2016: Terapevticheskiĭ Arkhiv
https://read.qxmd.com/read/26656547/liver-fibrosis-in-combined-course-of-chronic-hepatitis-c-and-hiv-infection
#37
JOURNAL ARTICLE
N Sarsekeyeva, B Kosherova, N Tabagari-Bregvadze
The urgency of the problem connected with HIV infection and parenteral forms of viral hepatitis largely stems from common epidemiological, social and economic indices. HIV infection accelerates progression of liver disease associated with HCV infection, especially in patients with more severe immunodeficiency. The aim of the study was to compare results of liver elastometry in patients co-infected with HIV/CHC and those monoinfected with CHC. Verification of the diagnosis was carried out on the basis of clinical-anamnestic data, by taking into account the epidemiological history of patients and confirming the results of enzyme immunoassay with the definition of markers of hepatitis C in paired sera and polymerase chain reaction with the detection of RNA virus in blood plasma...
November 2015: Georgian Medical News
https://read.qxmd.com/read/26371595/impact-of-cytomegalovirus-infection-on-severe-hepatitis-c-recurrence-in-patients-undergoing-liver-transplantation
#38
MULTICENTER STUDY
Juan Jose Caston, Luis Castells, Evaristo Varo, Miguel Angel Gomez, Manuel de la Mata, Isabel Campos-Varela, Carlos Lumbreras, Luisa Gonzalez-Dieguez, Joan Fabregat, Ignacio Herrero, Magdalena Salcedo, Gloria Sanchez-Antolín, Julian Torre-Cisneros
BACKGROUND: The influence of cytomegalovirus (CMV) on recurrent hepatitis C virus (HCV) in liver grafts is controversial. Our aim was to investigate the association between CMV infection and disease and severe HCV recurrence (composite variable of presence of stage 3 to 4 fibrosis, need for retransplantation or death due to liver disease) in the first year after transplantation. METHODS: An observational, prospective, multicenter study was performed. The CMV replication was monitored by determining CMV viral load weekly during hospitalization after transplantation, twice monthly in the first 3 months after discharge, and at each follow-up visit until month 12...
March 2016: Transplantation
https://read.qxmd.com/read/26328030/virological-response-and-resistance-mutations-to-ns3-4a-inhibitors-in-hepatitis-c-virus-human-immunodeficiency-virus-coinfection
#39
JOURNAL ARTICLE
Alissa Naqvi, Valérie Giordanengo, Brigitte Dunais, Francine de Salvador-Guillouet, Isabelle Perbost, Jacques Durant, Pascal Pugliese, Aline Joulié, Pierre Marie Roger, Eric Rosenthal
AIM: To evaluate virological response to telaprevir or boceprevir in combination with pegylated interferon and ribavirin and resistance mutations to NS3/4A inhibitors in hepatitis C virus-human immunodeficiency virus (HCV-HIV) coinfected patients in a real life setting. METHODS: Patients with HCV genotype 1-HIV coinfection followed in Nice University Hospital internal medicine and infectious diseases departments who initiated treatment including pegylated interferon and ribavirin (PegIFN/RBV) + telaprevir or boceprevir, according to standard treatment protocols, between August 2011 and October 2013 entered this observational study...
August 28, 2015: World Journal of Hepatology
https://read.qxmd.com/read/26000012/endothelial-dysfunction-correlates-with-liver-fibrosis-in-chronic-hcv-infection
#40
JOURNAL ARTICLE
Michele Barone, Maria Teresa Viggiani, Annabianca Amoruso, Serafina Schiraldi, Annapaola Zito, Fiorella Devito, Francesca Cortese, Michele Gesualdo, Natale Brunetti, Alfredo Di Leo, Pietro Scicchitano, Marco Matteo Ciccone
Background. Hepatitis C virus (HCV) infection can exert proatherogenic activities due to its direct action on vessel walls and/or via the chronic inflammatory process involving the liver. Aims. To clarify the role of HCV in atherosclerosis development in monoinfected HCV patients at different degrees of liver fibrosis and with no risk factors for coronary artery disease. Methods. Forty-five patients were included. Clinical, serological, and anthropometric parameters, liver fibrosis (transient liver elastometry (fibroscan) and aspartate aminotransferase to platelet ratio index (APRI)), carotid intima-media thickness (c-IMT), and brachial artery flow-mediated vasodilatation (FMD) were assessed...
2015: Gastroenterology Research and Practice
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