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Liver elastometry

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https://www.readbyqxmd.com/read/27801373/comparative-assessment-of-liver-fibrosis-in-patients-with-hiv-chronic-hepatitis-c-co-infection-in-different-ethnic-groups
#1
Nazgul Sarsekeyeva, Bakhyt Kosherova, Ilya Azizov
INTRODUCTION: In recent years, the frequency of human immunodeficiency virus (HIV) and hepatitis C (HCV) co-infection has increased, which is due to their common routes of transmission. HIV/chronic HCV co-infection aggravates the development of fibrosis and increases the risk of cirrhosis. The aim of the study was to evaluate the results of liver elastometry in patients of different ethnic groups with HIV/chronic HCV co-infection. METHODOLOGY: The study involved 49 Kazakh and 46 Russian patients with HIV/chronic HCV co-infection...
October 31, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/27271956/distribution-of-il28b-polymorphism-in-a-cohort-of-italians-and-immigrants-with-hcv-infection-association-with-viraemia-stage-of-fibrosis-and-response-to-treatment
#2
L Nosotti, A Petrelli, D Genovese, S Catone, C Argentini, S Vella, A Rossi, G Costanzo, A Fortino, L Chessa, L Miglioresi, C Mirisola
Aims of the study are to investigate, in a cohort of patients affected by HCV chronic hepatitis with genotypes 1 and 4, the prevalence of interleukin 28B (IL28B) genotypes, the possible association between IL28B polymorphism and severity of liver damage, the role of IL28B CC as a predictor of outcome. 365 patients with HCV infection were observed between 2013 and 2014. Demographic, virological, biochemical, and genetic characteristics of each patient were investigated. Liver fibrosis was assessed by transient elastometry...
June 6, 2016: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/27070167/-the-efficiency-and-safety-of-anti-helicobacter-pylori-therapy-in-patients-with-concomitant-chronic-hepatitis-c
#3
D N Andreev, I V Maev, Yu A Kucheryavyi, D T Dicheva, E V Partsvania-Vinogradova
AIM: To evaluate the efficiency and safety of two eradication therapy (ET) regimens for Helicobacter pylori infection in patients with concomitant chronic hepatitis C (CHC) in relation to the stage of liver fibrosis (LF). MATERIALS AND METHODS: A prospective clinical trial was conducted in parallel groups. Group 1 included 50 HCV-negative patients with H. pylori-associated peptic ulcer of the stomach or duodenum; Group 2 consisted of 50 HCV-positive patients with H...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/26656547/liver-fibrosis-in-combined-course-of-chronic-hepatitis-c-and-hiv-infection
#4
N Sarsekeyeva, B Kosherova, N Tabagari-Bregvadze
The urgency of the problem connected with HIV infection and parenteral forms of viral hepatitis largely stems from common epidemiological, social and economic indices. HIV infection accelerates progression of liver disease associated with HCV infection, especially in patients with more severe immunodeficiency. The aim of the study was to compare results of liver elastometry in patients co-infected with HIV/CHC and those monoinfected with CHC. Verification of the diagnosis was carried out on the basis of clinical-anamnestic data, by taking into account the epidemiological history of patients and confirming the results of enzyme immunoassay with the definition of markers of hepatitis C in paired sera and polymerase chain reaction with the detection of RNA virus in blood plasma...
November 2015: Georgian Medical News
https://www.readbyqxmd.com/read/26371595/impact-of-cytomegalovirus-infection-on-severe-hepatitis-c-recurrence-in-patients-undergoing-liver-transplantation
#5
MULTICENTER STUDY
Juan Jose Caston, Luis Castells, Evaristo Varo, Miguel Angel Gomez, Manuel de la Mata, Isabel Campos-Varela, Carlos Lumbreras, Luisa Gonzalez-Dieguez, Joan Fabregat, Ignacio Herrero, Magdalena Salcedo, Gloria Sanchez-Antolín, Julian Torre-Cisneros
BACKGROUND: The influence of cytomegalovirus (CMV) on recurrent hepatitis C virus (HCV) in liver grafts is controversial. Our aim was to investigate the association between CMV infection and disease and severe HCV recurrence (composite variable of presence of stage 3 to 4 fibrosis, need for retransplantation or death due to liver disease) in the first year after transplantation. METHODS: An observational, prospective, multicenter study was performed. The CMV replication was monitored by determining CMV viral load weekly during hospitalization after transplantation, twice monthly in the first 3 months after discharge, and at each follow-up visit until month 12...
March 2016: Transplantation
https://www.readbyqxmd.com/read/26328030/virological-response-and-resistance-mutations-to-ns3-4a-inhibitors-in-hepatitis-c-virus-human-immunodeficiency-virus-coinfection
#6
Alissa Naqvi, Valérie Giordanengo, Brigitte Dunais, Francine de Salvador-Guillouet, Isabelle Perbost, Jacques Durant, Pascal Pugliese, Aline Joulié, Pierre Marie Roger, Eric Rosenthal
AIM: To evaluate virological response to telaprevir or boceprevir in combination with pegylated interferon and ribavirin and resistance mutations to NS3/4A inhibitors in hepatitis C virus-human immunodeficiency virus (HCV-HIV) coinfected patients in a real life setting. METHODS: Patients with HCV genotype 1-HIV coinfection followed in Nice University Hospital internal medicine and infectious diseases departments who initiated treatment including pegylated interferon and ribavirin (PegIFN/RBV) + telaprevir or boceprevir, according to standard treatment protocols, between August 2011 and October 2013 entered this observational study...
August 28, 2015: World Journal of Hepatology
https://www.readbyqxmd.com/read/26000012/endothelial-dysfunction-correlates-with-liver-fibrosis-in-chronic-hcv-infection
#7
Michele Barone, Maria Teresa Viggiani, Annabianca Amoruso, Serafina Schiraldi, Annapaola Zito, Fiorella Devito, Francesca Cortese, Michele Gesualdo, Natale Brunetti, Alfredo Di Leo, Pietro Scicchitano, Marco Matteo Ciccone
Background. Hepatitis C virus (HCV) infection can exert proatherogenic activities due to its direct action on vessel walls and/or via the chronic inflammatory process involving the liver. Aims. To clarify the role of HCV in atherosclerosis development in monoinfected HCV patients at different degrees of liver fibrosis and with no risk factors for coronary artery disease. Methods. Forty-five patients were included. Clinical, serological, and anthropometric parameters, liver fibrosis (transient liver elastometry (fibroscan) and aspartate aminotransferase to platelet ratio index (APRI)), carotid intima-media thickness (c-IMT), and brachial artery flow-mediated vasodilatation (FMD) were assessed...
2015: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/25976473/thalassemia-major-between-liver-and-heart-where-we-are-now
#8
Carlo Dessì, GiovanBattista Leoni, Paolo Moi, Fabrice Danjou, Ilenia Follesa, Maria Loreta Foschini, Maddalena Morittu, Antonietta Zappu, Elisabetta Defraia, Patrizio Bina, Andrea Cunico, Alberto Civolani, Rosa Anna Podda, Raffaella Origa
The aim of the study was to assess the current state in terms of liver and heart iron overload as well as of liver and heart related morbidity and mortality in a large cohort of thalassemia patients. Myocardial iron loading was present in 28.9% patients, which was severe in 3.2%. Liver iron was normal in 9.3% and severe in 15%. The rate of cardiac deaths started to decrease between 2000 and 2003 and dropped significantly afterwards. The prescription of combination therapy soon after the hospital admission for decompensated heart failure was associated with a decrease in the short-term mortality...
June 2015: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/25960807/-13-co2-breath-tests-in-non-invasive-hepatological-diagnosis
#9
REVIEW
Joanna Musialik, Krzysztof Jonderko, Anna Kasicka-Jonderko, Magdalena Buschhaus
In liver diagnostics, a simple, non-invasive test with high sensitivity and specificity is permanently being sought in order to assess the degree of liver damage. In addition to liver biopsy, algorithms using blood parameters or elastometry are used in clinical practice. However, these methods do not provide information about the true liver reserve, so the liver breath test seem to be a promising diagnostic tool. The basis of this test depends on the ability of particular hepatocyte enzyme systems to metabolise a tested substance labelled with a stable carbon isotope...
2015: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/25817781/using-ultrasonic-transient-elastometry-fibroscan-to-predict-esophageal-varices-in-patients-with-viral-liver-cirrhosis
#10
Zhongwei Hu, Yuyuan Li, Chuo Li, Chunming Huang, Zhitao Ou, Jiawei Guo, Hongbin Luo, Xiaoping Tang
The correlation between liver stiffness (LS), measured by ultrasonic transient elastometry (FibroScan), and the presence and severity of esophageal varices (EV) in patients with viral cirrhosis of the liver has not been well documented to date. The study described here investigated the value of using FibroScan to predict EV. Patients with cirrhosis (200 patients: 167 cases caused by hepatitis B virus and 33 cases caused by hepatitis C virus) underwent both upper gastrointestinal endoscopy and FibroScan. Demographic, clinical, biochemical and endoscopic data and FibroScan-obtained LS parameters were collected...
June 2015: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/25372299/liver-fibrosis-progression-despite-hcv-cure-with-antiviral-therapy-in-hiv-hcv-coinfected-patients
#11
Pablo Labarga, Jose V Fernandez-Montero, Carmen de Mendoza, Pablo Barreiro, Javier Pinilla, Vincent Soriano
BACKGROUND: Accelerated liver fibrosis and more frequent hepatic decompensation events and liver-related deaths are characteristically seen in chronic hepatitis C patients coinfected with HIV compared with HCV-monoinfected individuals. Quantitative estimates of long-term clinical benefits derived from curing HCV with antiviral therapy in coinfected patients are scarce, despite being needed for accurate cost-effectiveness decisions using expensive direct-acting antivirals in this population...
2015: Antiviral Therapy
https://www.readbyqxmd.com/read/25337140/evaluating-liver-fibrosis-by-transient-elastometry-in-patients-with-hiv-hcv-coinfection-and-monoinfection
#12
Lucia Brescini, Elena Orsetti, Rosaria Gesuita, Francesca Piraccini, Elisa Marchionni, Silvia Staffolani, Pamela Castelli, Davide Drenaggi, Francesco Barchiesi
BACKGROUND: Due to the high efficacy of combination antiretroviral therapy (cART), the number of patients living with HIV is increasing. Chronic HCV infection has become a leading cause of non-AIDS related morbidity and mortality in patients with HIV infection. OBJECTIVES: The aim of this cross-sectional study was to identify factors associated with liver fibrosis (LF) in patients with HIV monoinfection and HIV-HCV coinfection. PATIENTS AND METHODS: We analyzed LF by transient elastometry ([TE], Fibroscan) in three groups of patients (HIV, HIV-HCV and HCV) followed at the Infectious Diseases Department of University of Ancona, Italy, between October 2009 and November 2012...
August 2014: Hepatitis Monthly
https://www.readbyqxmd.com/read/25244675/comparison-of-liver-fibrosis-progression-in-hiv-hcv-co-infected-and-hcv-mono-infected-patients-by-transient-elastometry
#13
COMPARATIVE STUDY
Susanna Mazzocato, Elena Orsetti, Rosaria Gesuita, Francesca Piraccini, Davide Drenaggi, Francesco Barchiesi
Monitoring of liver fibrosis (LF) is an essential tool for preventing liver-related complications in HIV/HCV co-infected patients. In this study, we compared LF progression by transient elastometry (TE) in 50 HIV/HCV co-infected and 115 HCV mono-infected patients followed in our institution between June 2006 and December 2011. Patients naive to interferon therapy and with at least two measurements of liver stiffness by TE were included. In all, 76% of HIV/HCV co-infected and 75% of HCV mono-infected patients remained in the same stage of LF over time...
November 2014: Scandinavian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/25111082/efficacy-of-prolonged-tenofovir-therapy-on-hepatitis-delta-in-hiv-infected-patients
#14
Vincent Soriano, Eugenia Vispo, Rocío Sierra-Enguita, Carmen de Mendoza, José V Fernández-Montero, Pablo Labarga, Pablo Barreiro
BACKGROUND: Hepatitis delta virus (HDV) produces the most severe form of chronic viral hepatitis. We explored whether prolonged tenofovir exposure might be beneficial on hepatitis delta in HIV-infected patients. METHODS: All HIV-infected patients with hepatitis delta followed at our institution since year 2000 were retrospectively examined. Serum HBV-DNA and HDV-RNA were quantified using commercial assays. Liver fibrosis was measured using elastometry. RESULTS: A total of 19 HIV/delta patients were identified...
October 23, 2014: AIDS
https://www.readbyqxmd.com/read/25086193/significant-variations-in-elastometry-measurements-made-within-short-term-in-patients-with-chronic-liver-diseases
#15
Fabio Nascimbeni, Pascal Lebray, Larysa Fedchuk, Claudia P Oliveira, Mario Reis Alvares-da-Silva, Anne Varault, Patrick Ingiliz, Yen Ngo, Mercedes de Torres, Mona Munteanu, Thierry Poynard, Vlad Ratziu
BACKGROUND & AIMS: Transient elastometry is a noninvasive procedure used to measure fibrosis when patients are diagnosed with liver disease; it might be used to monitor changes over time. We investigated whether there are short-term variations in stiffness measurements that are not attributable to changes in fibrosis by studying patients with stable liver disease. METHODS: We performed a retrospective analysis of 531 paired liver stiffness measurements made by Fibroscan when the study began (LSM1) and at follow-up (LSM2), more than 1 day and less than 1 year apart, from 432 stable (for body mass index, waist circumference, and alcohol consumption), untreated, immunocompetent patients with chronic liver disease (from January 2006 through March 2009)...
April 2015: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/25073725/comparison-of-liver-biopsy-and-noninvasive-techniques-for-liver-fibrosis-assessment-in-patients-infected-with-hcv-genotype-4-in-egypt
#16
P Bonnard, A Elsharkawy, K Zalata, E Delarocque-Astagneau, L Biard, L Le Fouler, A B Hassan, M Abdel-Hamid, M El-Daly, M E Gamal, M El Kassas, P Bedossa, F Carrat, A Fontanet, G Esmat
In Egypt, as elsewhere, liver biopsy (LB) remains the gold standard to assess liver fibrosis in chronic hepatitis C (CHC) and is required to decide whether a treatment should be proposed. Many of its disadvantages have led to develop noninvasive methods to replace LB. These new methods should be evaluated in Egypt, where circulating virus genotype 4 (G4), increased body mass index and co-infection with schistosomiasis may interfere with liver fibrosis assessment. Egyptian CHC-infected patients with G4 underwent a LB, an elastometry measurement (Fibroscan(©)), and serum markers (APRI, Fib4 and Fibrotest(©))...
March 2015: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/25071348/liver-fibrosis-evaluation-by-arfi-and-apri-in-chronic-hepatitis-c
#17
Su-Mei Li, Guang-Xia Li, Dong-Mei Fu, Yu Wang, Li-Qun Dang
AIM: To explore the value of liver fibrosis assessment by acoustic radiation force impulse (ARFI) and the AST/PLT ratio index (APRI) in chronic hepatitis C patients. METHODS: One hundred and twenty eight patients with chronic hepatitis C were examined using ARFI elastometry and APRI, calculated according to known formulae. The gold standard of liver biopsy was referred; ROC curve analysis was used to assess all ARFI and APRI values. The corresponding cut-off values, sensitivities, and specificities were calculated and compared...
July 28, 2014: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/24964405/progression-to-advanced-liver-fibrosis-in-hiv-hcv-coinfected-patients-and-prioritization-of-new-hepatitis-c-therapies
#18
Pablo Labarga, Jose V Fernández-Montero, Mariola López, Pablo Barreiro, Carmen de Mendoza, Rocío Sierra-Enguita, Ana Treviño, Vincent Soriano
BACKGROUND: Because of their high cost, the use of direct-acting antivirals (DAAs) is being restricted by many governments to chronic HCV-infected individuals with advanced liver fibrosis. However, response rates are lower and toxicities more frequent in this subset of patients. METHODS: All HIV-HCV-coinfected patients followed for at least 3 years at one reference clinic were identified. Liver fibrosis progression (LFP) was defined as a shift from Metavir F0-F2 to F3-F4 estimates (>9...
2014: Antiviral Therapy
https://www.readbyqxmd.com/read/24828359/cirrhosis-diagnosis-and-liver-fibrosis-staging-transient-elastometry-versus-cirrhosis-blood-test
#19
COMPARATIVE STUDY
Paul Calès, Jérôme Boursier, Frédéric Oberti, Derek Bardou, Jean-Pierre Zarski, Victor de Lédinghen
INTRODUCTION: Elastometry is more accurate than blood tests for cirrhosis diagnosis. However, blood tests were developed for significant fibrosis, with the exception of CirrhoMeter developed for cirrhosis. We compared the performance of Fibroscan and CirrhoMeter, and classic binary cirrhosis diagnosis versus new fibrosis staging for cirrhosis diagnosis. METHODS: The diagnostic population included 679 patients with hepatitis C and liver biopsy (Metavir staging and morphometry), Fibroscan, and CirrhoMeter...
July 2015: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/24772867/-non-invasive-techniques-in-diagnosis-of-steatosis-and-fibrosis-in-nonalcoholic-fatty-liver-disease
#20
RANDOMIZED CONTROLLED TRIAL
G E Roĭtberg, L B Lazebnik, L A Zvenigorodskaia, O O Sharkhun, T I Ushakova, O E Platonova
UNLABELLED: Diagnosis and treatment of nonalcoholic fatty liver disease (NAFLD) is one of the most actual problems of modern hepatology. Ultrasound elastometry is alternative method to determine the density of the liver tissue. The efficiency of the method was confirmed by a large amount of data in patients with viral hepatitis. However, the diagnostic value of elastometry was not studied enough in patients with NAFLD. THE AIM OF THE RESEARCH: to study the possibility of non-invasive diagnostic methods of examination in a complex assessment of the liver in patients with NAFLD...
2013: Experimental & Clinical Gastroenterology
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