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Bunyavirus

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https://www.readbyqxmd.com/read/29754008/vascular-endothelial-injury-in-severe-fever-with-thrombocytopenia-syndrome-caused-by-the-novel-bunyavirus
#1
Xiao-Kun Li, Shao-Fei Zhang, Wen Xu, Bo Xing, Qing-Bin Lu, Pan-He Zhang, Hao Li, Li Zhang, Wen-Cong Zhang, Wei-Wei Chen, Wu-Chun Cao, Wei Liu
Severe fever with thrombocytopenia syndrome virus (SFTSV) infection typically causes acute fever, thrombocytopenia and leucopenia, presenting with a high case fatality rate. The pathogenesis of SFTSV infection, however, is not well described. It was hypothesized that endothelial dysfunction might play part in the disease process. In current study, we retrospectively analyzed the clinical manifestations among a large group of confirmed SFTS cases and found evidence of plasma leakage and vascular endothelial injury...
May 10, 2018: Virology
https://www.readbyqxmd.com/read/29730989/identification-of-tick-borne-pathogen-diversity-by-metagenomic-analysis-in-haemaphysalis-longicornis-from-xinyang-china
#2
Lu Zhuang, Juan Du, Xiao-Ming Cui, Hao Li, Fang Tang, Pan-He Zhang, Jian-Gong Hu, Yi-Gang Tong, Zhi-Chun Feng, Wei Liu
BACKGROUND: A wide variety of pathogens could be maintained and transmitted by Haemaphysalis longicornis. The aim of this study is to systematically examine the variety of pathogens carried by Haemaphysalis longicornis, an importnatn vector, in tick-borne diseases epidemic area, and to estimate the risk of human infection imposed by tick bites. METHODS: Adult questing ticks were collected in Xinyang, central China. Genomic DNA and RNA were extracted from 144 H. longicornis ticks individually, and sequenced respectively as the templates for high-throughput sequencing...
May 7, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29718685/vector-competence-of-certain-culex-and-aedes-mosquitoes-for-the-chittoor-virus-the-indian-variant-of-batai-virus
#3
Anakkathil Balan Sudeep, Neda Shaikh, Youwaraj Ghodke, Viswas Ingale, Mangesh Gokhale
Chittoor virus (CHITV), a mosquito-borne bunyavirus (Orthobunyavirus: Bunyaviridae) isolated in India, has been found to be antigenically close to the Batai virus (BATV),which has a wide distribution across Asia, Europe and Africa. The latter causes influenza-like illness in humans and mild illness in sheep and goats. BATV has been involved in genetic reassortment with other bunyaviruses, generating novel genome combinations and causing severe clinical manifestations including hemorrhagic fever. Conversely, CHITV has never been associated with any major outbreaks in India, although neutralizing antibodies have been detected in humans and domestic animals...
May 2, 2018: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/29707545/a-review-of-bunyamwera-batai-and-ngari-viruses-understudied-orthobunyaviruses-with-potential-one-health-implications
#4
REVIEW
M Fausta Dutuze, Manassé Nzayirambaho, Christopher N Mores, Rebecca C Christofferson
Bunyamwera (BUNV), Batai (BATV), and Ngari (NRIV) are mosquito-borne viruses of the Bunyamwera serogroup in the Orthobunyavirus genus of the Bunyaviridae family. These three viruses have been found to cause disease in both livestock animals, avian species, and humans. Thus, these viruses pose a potential threat to human public health, animal health, and food security. This is especially the case in the developing nations, where BUNV and NRIV are found, mainly in Africa. BUNV and BATV are fairly well characterized, while NRIV is not well characterized owing to only sporadic detection in human and animal populations in Africa...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29695422/isg-expression-screening-reveals-the-specific-antibunyaviral-activity-of-isg20
#5
Junjie Feng, Arthur Wickenhagen, Matthew L Turnbull, Veronica V Rezelj, Felix Kreher, Natasha L Tilston-Lunel, Gillian S Slack, Benjamin Brennan, Elina Koudriakova, Andrew E Shaw, Suzannah J Rihn, Charles M Rice, Paul D Bieniasz, Richard M Elliott, Xiaohong Shi, Sam J Wilson
Bunyaviruses pose a significant threat to human health, prosperity and food security. In response to viral infections, interferons (IFNs) upregulate the expression of hundreds of interferon stimulated genes (ISGs) whose cumulative action can potently inhibit the replication of bunyaviruses. We used a flow cytometry-based method to screen the ability of ∼500 unique ISGs from humans and rhesus macaques to inhibit the replication of Bunyamwera orthobunyavirus (BUNV), the prototype of both the Peribunyaviridae family and Bunyavirales order...
April 25, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29692303/bunyavirus-taxonomy-limitations-and-misconceptions-associated-with-the-current-ictv-criteria-used-for-species-demarcation
#6
Bradley J Blitvich, Barry J Beaty, Carol D Blair, Aaron C Brault, Gerhard Dobler, Michael A Drebot, Andrew D Haddow, Laura D Kramer, Angelle Desiree LaBeaud, Thomas P Monath, Eric C Mossel, Kenneth Plante, Ann M Powers, Robert B Tesh, Michael J Turell, Nikos Vasilakis, Scott C Weaver
The International Committee on Taxonomy of Viruses (ICTV) has implemented numerous changes to the taxonomic classification of bunyaviruses over the years. Whereas most changes have been justified and necessary because of the need to accommodate newly discovered and unclassified viruses, other changes are a cause of concern, especially the decision to demote scores of formerly recognized species to essentially strains of newly designated species. This practice was first described in the seventh taxonomy report of the ICTV and has continued in all subsequent reports...
April 23, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29678879/potassium-is-a-trigger-for-conformational-change-in-the-fusion-spike-of-an-enveloped-rna-virus
#7
Emma K Punch, Samantha Hover, Henry Tw Blest, Jack Fuller, Roger Hewson, Juan Fontana, Jamel Mankouri, John N Barr
Many enveloped viruses enter cells through the endocytic network, from which they must subsequently escape through fusion of viral and endosomal membranes. This membrane fusion is mediated by virus-encoded spikes that respond to the changing endosomal environment, which triggers conformational change in the spike that initiate the fusion process. Several fusion triggers have been identified and include pH, membrane composition and endosome-resident proteins and these cues dictate when and where viral fusion occurs...
April 20, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29626301/nucleoprotein-from-the-unique-human-infecting-orthobunyavirus-of-simbu-serogroup-oropouche-virus-forms-higher-order-oligomers-in-complex-with-nucleic-acids-in-vitro
#8
Juliana Londoño Murillo, Aline Diniz Cabral, Mabel Uehara, Viviam Moura da Silva, Juliete Vitorino Dos Santos, João Renato Carvalho Muniz, Leandro Farias Estrozi, Daphna Fenel, Wanius Garcia, Márcia Aparecida Sperança
Oropouche virus (OROV) is the unique known human pathogen belonging to serogroup Simbu of Orthobunyavirus genus and Bunyaviridae family. OROV is transmitted by wild mosquitoes species to sloths, rodents, monkeys and birds in sylvatic environment, and by midges (Culicoides paraensis and Culex quinquefasciatus) to man causing explosive outbreaks in urban locations. OROV infection causes dengue fever-like symptoms and in few cases, can cause clinical symptoms of aseptic meningitis. OROV contains a tripartite negative RNA genome encapsidated by the viral nucleocapsid protein (NP), which is essential for viral genome encapsidation, transcription and replication...
April 6, 2018: Amino Acids
https://www.readbyqxmd.com/read/29579040/sensitive-and-specific-detection-of-crimean-congo-hemorrhagic-fever-virus-cchfv-specific-igm-and-igg-antibodies-in-human-sera-using-recombinant-cchfv-nucleoprotein-as-antigen-in-%C3%AE-capture-and-igg-immune-complex-ic-elisa-tests
#9
Petra Emmerich, Angela Mika, Ronald von Possel, Anne Rackow, Yang Liu, Herbert Schmitz, Stephan Günther, Kurtesh Sherifi, Barie Halili, Xhevat Jakupi, Lindita Berisha, Salih Ahmeti, Christina Deschermeier
As the most widespread tick-borne arbovirus causing infections in numerous countries in Asia, Africa and Europe, Crimean-Congo Hemorrhagic Fever Virus (CCHFV, family Nairoviridae) was included in the WHO priority list of emerging pathogens needing urgent Research & Development attention. To ensure preparedness for potential future outbreak scenarios, reliable diagnostic tools for identification of acute cases as well as for performance of seroprevalence studies are necessary. Here, the CCHFV ortholog of the major bunyavirus antigen, the nucleoprotein (NP), was recombinantly expressed in E...
March 26, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29516765/bunyavirales-ribonucleoproteins-the-viral-replication-and-transcription-machinery
#10
Yeping Sun, Jing Li, George F Gao, Po Tien, Wenjun Liu
The Bunyavirales order is one of the largest groups of segmented negative-sense single-stranded RNA viruses, which includes many pathogenic strains that cause severe human diseases. The RNA segments of the bunyavirus genome are separately encapsidated by multiple copies of nucleoprotein (N), and both termini of each N-encapsidated genomic RNA segment bind to one copy of the viral L polymerase protein. The viral genomic RNA, N and L protein together form the ribonucleoprotein (RNP) complex that constitutes the molecular machinery for viral genome replication and transcription...
March 8, 2018: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/29391683/cryptic-etiopathological-conditions-of-equine-nervous-system-with-special-emphasis-on-viral-diseases
#11
REVIEW
Rakesh Kumar, Rajendra D Patil
The importance of horse ( Equus caballus ) to equine practitioners and researchers cannot be ignored. An unevenly distributed population of equids harbors numerous diseases, which can affect horses of any age and breed. Among these, the affections of nervous system are potent reason for death and euthanasia in equids. Many episodes associated with the emergence of equine encephalitic conditions have also pose a threat to human population as well, which signifies their pathogenic zoonotic potential. Intensification of most of the arboviruses is associated with sophisticated interaction between vectors and hosts, which supports their transmission...
December 2017: Veterinary World
https://www.readbyqxmd.com/read/29352299/bunyavirus-requirement-for-endosomal-k-reveals-new-roles-of-cellular-ion-channels-during-infection
#12
Samantha Hover, Becky Foster, Juan Fontana, Alain Kohl, Steve A N Goldstein, John N Barr, Jamel Mankouri
In order to multiply and cause disease a virus must transport its genome from outside the cell into the cytosol, most commonly achieved through the endocytic network. Endosomes transport virus particles to specific cellular destinations and viruses exploit the changing environment of maturing endocytic vesicles as triggers to mediate genome release. Previously we demonstrated that several bunyaviruses, which comprise the largest family of negative sense RNA viruses, require the activity of cellular potassium (K+) channels to cause productive infection...
January 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29284754/viral-discovery-and-diversity-in-trypanosomatid-protozoa-with-a-focus-on-relatives-of-the-human-parasite-leishmania
#13
Danyil Grybchuk, Natalia S Akopyants, Alexei Y Kostygov, Aleksandras Konovalovas, Lon-Fye Lye, Deborah E Dobson, Haroun Zangger, Nicolas Fasel, Anzhelika Butenko, Alexander O Frolov, Jan Votýpka, Claudia M d'Avila-Levy, Pavel Kulich, Jana Moravcová, Pavel Plevka, Igor B Rogozin, Saulius Serva, Julius Lukeš, Stephen M Beverley, Vyacheslav Yurchenko
Knowledge of viral diversity is expanding greatly, but many lineages remain underexplored. We surveyed RNA viruses in 52 cultured monoxenous relatives of the human parasite Leishmania ( Crithidia and Leptomonas ), as well as plant-infecting Phytomonas Leptomonas pyrrhocoris was a hotbed for viral discovery, carrying a virus (Leptomonas pyrrhocoris ostravirus 1) with a highly divergent RNA-dependent RNA polymerase missed by conventional BLAST searches, an emergent clade of tombus-like viruses, and an example of viral endogenization...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29281642/transmission-of-rift-valley-fever-virus-from-european-breed-lambs-to-culex-pipiens-mosquitoes
#14
Rianka P M Vloet, Chantal B F Vogels, Constantianus J M Koenraadt, Gorben P Pijlman, Martin Eiden, Jose L Gonzales, Lucien J M van Keulen, Paul J Wichgers Schreur, Jeroen Kortekaas
BACKGROUND: Rift Valley fever virus (RVFV) is a mosquito-borne bunyavirus of the genus Phlebovirus that is highly pathogenic to ruminants and humans. The disease is currently confined to Africa and the Arabian Peninsula, but globalization and climate change may facilitate introductions of the virus into currently unaffected areas via infected animals or mosquitoes. The consequences of such an introduction will depend on environmental factors, the availability of susceptible ruminants and the capacity of local mosquitoes to transmit the virus...
December 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29210509/arboviruses-and-their-related-infections-in-china-a-comprehensive-field-and-laboratory-investigation-over-the-last-3-decades
#15
REVIEW
Guodong Liang, Xiaolong Li, Xiaoyan Gao, Shihong Fu, Huanyu Wang, Minghua Li, Zhi Lu, Wuyang Zhu, Xinjun Lu, Lihua Wang, Yuxi Cao, Ying He, Wenwen Lei
Since the 1980s, a comprehensive field and laboratory investigation has been conducted throughout China, and a total of 29 virus species belonging to 7 families and 13 genera were identified through virological, morphological, and immunological methods, as well as whole-genome sequencing and molecular genetic analyses. Most of the virus isolates belong to 9 genera in the families Flaviviridae, Bunyaviridae, Togaviridae, and Reoviridae. Among them, 4 genera (Orthobunyavirus, Bunyavirus, Phlebovirus, and Nairovirus) belong to the family Bunyaviridae and 3 genera (Seadonavirus, Orbivirus, and Cypovirus) belong to the family Reoviridae...
January 2018: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29186956/how-viruses-infiltrate-the-central-nervous-system
#16
A Michalicová, K Bhide, M Bhide, A Kováč
Central nervous system is protected by the blood-brain barrier, which represents a physical, metabolic and transport barrier and is considered to be a part of a highly dynamic system termed neurovascular unit. Several pathogens, among them viruses, are able to invade the brain. Traversal of viruses across the blood-brain barrier is an essential step for the invasion of the central nervous system and can occur by different mechanisms - by paracellular, transcellular and/or by "Trojan horse" pathway...
2017: Acta Virologica
https://www.readbyqxmd.com/read/29181086/recent-advances-in-the-development-of-antiviral-therapeutics-for-rift-valley-fever-virus-infection
#17
REVIEW
Colm Atkins, Alexander N Freiberg
Rift Valley fever virus (RVFV) is a mosquito-borne bunyavirus endemic to sub-Saharan Africa and the Arabian Peninsula and the etiological agent of Rift Valley fever. Rift Valley fever is a disease of major public health and economic concern, affecting livestock and humans. In ruminants, RVFV infection is characterized by high mortality rates in newborns and near 100% abortion rates in pregnant animals. Infection in humans is typically manifested as a self-limiting febrile illness, but can lead to severe and fatal hepatitis, encephalitis, hemorrhagic fever or retinitis with partial or complete blindness...
November 2017: Future Virology
https://www.readbyqxmd.com/read/29138019/a-patient-with-severe-fever-with-thrombocytopenia-syndrome-and-hemophagocytic-lymphohistiocytosis-associated-involvement-of-the-central-nervous-system
#18
Masahiko Kaneko, Hisaharu Shikata, Shoichi Matsukage, Masaki Maruta, Hiroto Shinomiya, Tadaki Suzuki, Hideki Hasegawa, Masayuki Shimojima, Masayuki Saijo
Severe fever with thrombocytopenia syndrome (SFTS), a severe infectious disease caused by novel bunyavirus, SFTS virus (SFTSV), is endemic to China, Korea, and Japan. Most SFTS patients show abnormalities in consciousness. Pathological findings in the central nervous system (CNS) of SFTS patients are not reported. A 53-year-old Japanese man was admitted to Uwajima City Hospital with an 8-day history of fever and diarrhea. Laboratory tests revealed leukopenia, thrombocytopenia, and liver enzyme elevation. He was diagnosed as having severe fever with thrombocytopenia syndrome (SFTS) following detection of the SFTSV genome in his blood...
April 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29128377/viral-hemorrhagic-fever-in-the-tropics-report-from-the-task-force-on-tropical-diseases-by-the-world-federation-of-societies-of-intensive-and-critical-care-medicine
#19
REVIEW
Jorge Hidalgo, Guy A Richards, Juan Ignacio Silesky Jiménez, Tim Baker, Pravin Amin
Viral hemorrhagic fevers (VHFs) are a group of illnesses caused by four families of viruses namely Arenaviruses, Filoviruses, Bunyaviruses, and Flaviviruses. Humans are not the natural reservoir for any of these organisms and acquire the disease through vectors from animal reservoirs. In some conditions human to human transmission is possible increasing the risk to healthy individuals in the vicinity, more so to Health Care Workers (HCW). The pathogenesis of VHF, though poorly understood, varies according to the viruses involved...
December 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29070692/the-postfusion-structure-of-the-heartland-virus-gc-glycoprotein-supports-taxonomic-separation-of-the-bunyaviral-families-phenuiviridae-and-hantaviridae
#20
Yaohua Zhu, Yan Wu, Yan Chai, Jianxun Qi, Ruchao Peng, Wen-Hai Feng, George Fu Gao
Heartland virus (HRTV) is an emerging human pathogen that belongs to the newly defined family Phenuiviridae , order Bunyavirales Gn and Gc are two viral surface glycoproteins encoded by the M segment and are required for early events during infection. HRTV delivers its genome into the cytoplasm by fusion of the viral envelope and endosomal membranes under low-pH conditions. Here, we describe the crystal structure of HRTV Gc in its postfusion conformation. The structure shows that Gc displays a typical class II fusion protein conformation, and the overall structure is identical to severe fever with thrombocytopenia syndrome virus (SFTSV) Gc, which also belongs to the Phenuiviridae family...
January 1, 2018: Journal of Virology
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