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https://www.readbyqxmd.com/read/28934195/a-scoring-model-for-predicting-prognosis-of-patients-with-severe-fever-with-thrombocytopenia-syndrome
#1
Bei Jia, Xiaomin Yan, Yuxin Chen, Guiyang Wang, Yong Liu, Biyun Xu, Peixin Song, Yang Li, Yali Xiong, Weihua Wu, Yingying Hao, Juan Xia, Zhaoping Zhang, Rui Huang, Chao Wu
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging epidemic infectious disease caused by the SFTS bunyavirus (SFTSV) with an estimated high case-fatality rate of 12.7% to 32.6%. Currently, the disease has been reported in mainland China, Japan, Korea, and the United States. At present, there is no specific antiviral therapy for SFTSV infection. Considering the higher mortality rate and rapid clinical progress of SFTS, supporting the appropriate treatment in time to SFTS patients is critical. Therefore, it is very important for clinicians to predict these SFTS cases who are more likely to have a poor prognosis or even more likely to decease...
September 21, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28926632/risk-analysis-of-inter-species-reassortment-through-a-rift-valley-fever-phlebovirus-mp-12-vaccine-strain
#2
Hoai J Ly, Nandadeva Lokugamage, Shoko Nishiyama, Tetsuro Ikegami
Rift Valley fever (RVF) is a mosquito-borne zoonotic disease endemic to Africa and the Arabian Peninsula. The causative agent, Rift Valley fever phlebovirus (RVFV), belongs to the genus Phlebovirus in the family Phenuiviridae and causes high rates of abortions in ruminants, and hemorrhagic fever, encephalitis, or blindness in humans. Viral maintenance by mosquito vectors has led to sporadic RVF outbreaks in ruminants and humans in endemic countries, and effective vaccination of animals and humans may minimize the impact of this disease...
2017: PloS One
https://www.readbyqxmd.com/read/28904194/a-distinct-mechanism-for-the-formation-of-the-ribonucleoprotein-complex-of-the-tomato-spotted-wilt-virus
#3
Yu Guo, Baocheng Liu, Zhenzhen Ding, Guobang Li, Meizi Liu, Dantong Zhu, Yuna Sun, Shishang Dong, Zhiyong Lou
The tomato spotted wilt virus (TSWV) belongs to the Tospovirus genus of the Bunyaviridae family and represents the sole plant-infecting group within bunyavirus. TSWV encodes a nucleocapsid protein (N) which encapsidates the RNA genome to form a ribonucleoprotein complex (RNP). In addition, the N has multiple roles during the infection of plant cells. Here, we report the crystal structure of the full-length TSWV N. The N features a body domain consisting of an N- and C-lobe. These lobes clamp a positively charged groove which may constitute the RNA binding site...
September 13, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28888768/assessment-of-a-cricket-acheta-domesticus-bioassay-for-chequa-iflavirus-and-bunya-like-virus-from-redclaw-crayfish-cherax-quadricarinatus
#4
Kitikarn Sakuna, Jennifer Elliman, Leigh Owens
Chequa iflavirus and a bunya-like virus infect redclaw crayfish (Cherax quadricarinatus) and they may cause mortality reaching 20-40% after about three weeks after a stress event. To complete River's postulates for viruses, virus-free animals are needed. Due to a lack of chequa iflavirus and bunya-like virus-free crayfish (testing shows>85% infection rate) coupled with the facts that iflavirus and bunyaviruses are found in insects and that crickets had been successful alternate hosts for crustacean viruses before, Acheta domesticus was trialled asa bioassay animal...
September 6, 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/28885138/characterization-of-five-unclassified-orthobunyaviruses-bunyaviridae-from-africa-and-the-americas
#5
Mathew B Rogers, Kristen M Gulino, Robert B Tesh, Lijia Cui, Adam Fitch, Thomas R Unnasch, Vsevolod L Popov, Amelia P A Travassos da Rosa, Hilda Guzman, Jean-Paul Carrera, Nikos Vasilakis, Elodie Ghedin
The Bunyaviridae family is made up of a diverse range of viruses, some of which cause disease and are a cause for concern in human and veterinary health. Here, we report the genomic and antigenic characterization of five previously uncharacterized bunyaviruses. Based on their ultrastructure, antigenic relationships and phylogenomic relationships, the five viruses are classified as members of the Orthobunyavirus genus. Three are viruses in the California encephalitis virus serogroup and are related to Trivittatus virus; the two others are most similar to the Mermet virus in the Simbu serogroup, and to the Tataguine virus, which is not currently assigned to a serogroup...
September 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28883464/characterizing-the-virome-of-ixodes-ricinus-ticks-from-northern-europe
#6
John H-O Pettersson, Mang Shi, Jon Bohlin, Vegard Eldholm, Ola B Brynildsrud, Katrine Mørk Paulsen, Åshild Andreassen, Edward C Holmes
RNA viruses are abundant infectious agents and present in all domains of life. Arthropods, including ticks, are well known as vectors of many viruses of concern for human and animal health. Despite their obvious importance, the extent and structure of viral diversity in ticks is still poorly understood, particularly in Europe. Using a bulk RNA-sequencing approach that captures the complete transcriptome, we analysed the virome of the most common tick in Europe - Ixodes ricinus. In total, RNA sequencing was performed on six libraries consisting of 33 I...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28846485/plant-made-vaccines-and-reagents-for-the-one-health-initiative
#7
Edward Peter Rybicki
The One Health initiative is increasingly becoming a prominent discussion topic in animal and human health, with its focus on prevention of spread of zoonotic diseases, both in animals, and from animals to humans. An important part of One Health is that diagnostics and vaccines for diseases may be the same thing - and be used for both humans and animals. One potential problem standing in the way of wider adoption of One Health principles, though, is that use of conventional cell fermentation systems for production of the recombinant proteins that could be used as diagnostics or vaccines is often expensive and is not easily scalable...
August 28, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28827346/structures-of-phlebovirus-glycoprotein-gn-and-identification-of-a-neutralizing-antibody-epitope
#8
Yan Wu, Yaohua Zhu, Feng Gao, Yongjun Jiao, Babayemi O Oladejo, Yan Chai, Yuhai Bi, Shan Lu, Mengqiu Dong, Chang Zhang, Guangmei Huang, Gary Wong, Na Li, Yanfang Zhang, Yan Li, Wen-Hai Feng, Yi Shi, Mifang Liang, Rongguang Zhang, Jianxun Qi, George F Gao
Severe fever with thrombocytopenia syndrome virus (SFTSV) and Rift Valley fever virus (RVFV) are two arthropod-borne phleboviruses in the Bunyaviridae family, which cause severe illness in humans and animals. Glycoprotein N (Gn) is one of the envelope proteins on the virus surface and is a major antigenic component. Despite its importance for virus entry and fusion, the molecular features of the phleboviruse Gn were unknown. Here, we present the crystal structures of the Gn head domain from both SFTSV and RVFV, which display a similar compact triangular shape overall, while the three subdomains (domains I, II, and III) making up the Gn head display different arrangements...
August 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28820686/the-emergence-of-severe-fever-with-thrombocytopenia-syndrome-virus
#9
Jesus A Silvas, Patricia V Aguilar
Severe fever with thrombocytopenia syndrome (SFTS) is a newly recognized hemorrhagic fever disease found throughout Asia with a case fatality rate between 12% and 30%. Since 2009, SFTS has been reported in China throughout 14 Chinese Provinces. In addition, SFTS has been recognized in South Korea and Japan with the first confirmed cases reported in 2012. A similar disease, caused by the closely related Heartland virus, was also reported in the United States in 2009. SFTS is caused by SFTS virus, a novel tick-borne virus in the family Bunyaviridae, genus Phlebovirus...
August 7, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28807043/an-equine-herpesvirus-type-1-ehv-1-vector-expressing-rift-valley-fever-virus-rvfv-gn-and-gc-induces-neutralizing-antibodies-in-sheep
#10
Abdelrahman Said, Mona Elmanzalawy, Guanggang Ma, Armando Mario Damiani, Nikolaus Osterrieder
Rift Valley fever virus (RVFV) is an arthropod-borne bunyavirus that can cause serious and fatal disease in humans and animals. RVFV is a negative-sense RNA virus of the Phlebovirus genus in the Bunyaviridae family. The main envelope RVFV glycoproteins, Gn and Gc, are encoded on the M segment of RVFV and known inducers of protective immunity. In an attempt to develop a safe and efficacious RVF vaccine, we constructed and tested a vectored equine herpesvirus type 1 (EHV-1) vaccine that expresses RVFV Gn and Gc...
August 14, 2017: Virology Journal
https://www.readbyqxmd.com/read/28777080/toscana-virus-nucleoprotein-oligomer-organization-observed-in-solution
#11
Amal Baklouti, Adeline Goulet, Julie Lichière, Bruno Canard, Rémi N Charrel, François Ferron, Bruno Coutard, Nicolas Papageorgiou
Toscana virus (TOSV) is an arthropod-borne virus belonging to the Phlebovirus genus within the Bunyaviridae family. As in other bunyaviruses, the genome of TOSV is made up of three RNA segments. They are encapsidated by the nucleoprotein (N), which also plays an essential role in virus replication. To date, crystallographic structures of phlebovirus N have systematically revealed closed-ring organizations which do not fully match the filamentous organization of the ribonucleoprotein (RNP) complex observed by electron microscopy...
August 1, 2017: Acta Crystallographica. Section D, Structural Biology
https://www.readbyqxmd.com/read/28769016/favipiravir-t-705-a-broad-spectrum-inhibitor-of-viral-rna-polymerase
#12
Yousuke Furuta, Takashi Komeno, Takaaki Nakamura
Favipiravir (T-705; 6-fluoro-3-hydroxy-2-pyrazinecarboxamide) is an anti-viral agent that selectively and potently inhibits the RNA-dependent RNA polymerase (RdRp) of RNA viruses. Favipiravir was discovered through screening chemical library for anti-viral activity against the influenza virus by Toyama Chemical Co., Ltd. Favipiravir undergoes an intracellular phosphoribosylation to be an active form, favipiravir-RTP (favipiravir ribofuranosyl-5'-triphosphate), which is recognized as a substrate by RdRp, and inhibits the RNA polymerase activity...
2017: Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
https://www.readbyqxmd.com/read/28757043/a-large-scale-serological-survey-of-akabane-virus-infection-in-cattle-yak-sheep-and-goats-in-china
#13
Jidong Wang, Kim R Blasdell, Hong Yin, Peter J Walker
Akabane virus (AKAV) is a member of the Simbu serogroup, classified in the genus Orthobunyavirus, family Bunyaviridae. AKAV infection can cause abortion, stillbirth, and congenital arthrogryposis and hydranencephaly in cattle and sheep. The distribution and prevalence of AKAV infection in China is still unknown. A total of 2731 sera collected from 2006 to 2015 in 24 provinces of China from cattle, sheep, goats and yak were examined by serum neutralisation test. The overall seroprevalence rates for AKAV antibodies were 21...
August 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28747721/downregulation-of-interferon-%C3%AE-and-inhibition-of-tlr3-expression-are-associated-with-fatal-outcome-of-severe-fever-with-thrombocytopenia-syndrome
#14
Peixin Song, Nan Zheng, Li Zhang, Yong Liu, Taoyu Chen, Changjun Bao, Zhifeng Li, Wei Yong, Yongyang Zhang, Chao Wu, Zhiwei Wu
Severe Fever with Thrombocytopenia Syndrome (SFTS) is an emerging infectious disease with high mortality and increasing prevalence in the East Asia. Though the etiological agent has been identified as a novel Bunyavirus, cellular mechanisms of viral pathogenesis and host immune response to SFTS virus infection remain unknown. A comprehensive study was conducted on a cohort of 70 patients on clinical manifestations, viral loads, modulation of cytokines, serum interferon level, immune related gene expression in peripheral blood cells, and dynamic changes of circulating dendritic cells during the acute phase of SFTSV infection...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28680969/differential-antagonism-of-human-innate-immune-responses-by-tick-borne-phlebovirus-nonstructural-proteins
#15
Veronica V Rezelj, Ping Li, Vidyanath Chaudhary, Richard M Elliott, Dong-Yan Jin, Benjamin Brennan
In recent years, several newly discovered tick-borne viruses causing a wide spectrum of diseases in humans have been ascribed to the Phlebovirus genus of the Bunyaviridae family. The nonstructural protein (NSs) of bunyaviruses is the main virulence factor and interferon (IFN) antagonist. We studied the molecular mechanisms of IFN antagonism employed by the NSs proteins of human apathogenic Uukuniemi virus (UUKV) and those of Heartland virus (HRTV) and severe fever with thrombocytopenia syndrome virus (SFTSV), both of which cause severe disease...
May 2017: MSphere
https://www.readbyqxmd.com/read/28628828/sensitivity-to-bst-2-restriction-correlates-with-orthobunyavirus-host-range
#16
Mariana Varela, Ilaria M Piras, Catrina Mullan, Xiaohong Shi, Natasha L Tilston-Lunel, Rute Maria Pinto, Aislynn Taggart, Stephen R Welch, Stuart J D Neil, Felix Kreher, Richard M Elliott, Massimo Palmarini
Orthobunyaviruses include several recently emerging viruses of significant medical and veterinary importance. There is currently very limited understanding on what determines the host species range of these pathogens. In this study we discovered that BST-2/tetherin restricts orthobunyavirus replication in a host-specific manner. We show that viruses with human tropism (Oropouche virus and La Crosse virus) are restricted by sheep BST-2 but not by the human orthologue, while viruses with ruminant tropism (Schmallenberg virus and others) are restricted by human BST-2 but not by the sheep orthologue...
September 2017: Virology
https://www.readbyqxmd.com/read/28626191/hemophagocytic-lymphohistiocytosis-in-a-fatal-case-of-severe-fever-with-thrombocytopenia-syndrome
#17
Ayako Nakano, Hirohisa Ogawa, Yoshinori Nakanishi, Hiromi Fujita, Fumihiko Mahara, Kazuya Shiogama, Yutaka Tsutsumi, Toshiaki Takeichi
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging disease caused by a novel Bunyavirus with a high mortality rate. We herein report a fatal case of an 86-year-old woman with SFTS complaining of a fever, fatigue, and bicytopenia. Her condition deteriorated with rapid progression of bleeding tendency, disturbance of consciousness, and multiple organ failure leading to death on Day 6 of her illness. The histopathological findings in the autopsy revealed marked infiltration of macrophages with hemophagocytosis in the bone marrow, liver, and spleen leading to a diagnosis of hemophagocytic lymphohistiocytosis (HLH)...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28592543/mapping-of-transcription-termination-within-the-s-segment-of-sfts-phlebovirus-facilitated-generation-of-nss-deletant-viruses
#18
Benjamin Brennan, Veronica V Rezelj, Richard M Elliott
SFTS phlebovirus (SFTSV) is an emerging tick-borne bunyavirus that was first reported in China in 2009. Here we report the generation of a recombinant SFTSV (rHB29NSsKO) that cannot express the viral nonstructural protein (NSs) upon infection of cells in culture. We show that rHB29NSsKO replication kinetics are greater in interferon (IFN)-incompetent cells and that the virus is unable to suppress IFN induced in response to viral replication. The data confirm for the first time in the context of virus infection that NSs acts as a virally encoded IFN antagonist and that NSs is dispensable for virus replication...
August 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28569189/experimental-infections-of-mosquitoes-with-severe-fever-with-thrombocytopenia-syndrome-virus
#19
Shu-Yi Liang, Hong-Liang Chu, Xi-Ling Guo, Wei Wang, Hong-Na Chen, Yu-Fu Zhang, Yin Chen, Tao Wu, Chang-Jun Bao, Ming-Hao Zhou
BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) is a newly identified emerging infectious disease, which is caused by a novel bunyavirus (termed SFTSV) in Asia. Although mosquitoes have not been identified as the primary vectors, as revealed by epidemiological surveys, their role in transmitting this SFTSV as a suspicious vector has not been validated. FINDINGS: In this study, we conducted experimental infections of mosquitoes with SFTSV to examine the role of mosquitoes in the transmission of the virus...
June 1, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28560174/pediatric-huaiyangshan-virus-infection-a-case-report-with-literature-review
#20
Chun-Hui Zhu, Dong Xu, Wei Liu, Di Guo, Qin Ning, Guang Chen
To define the clinical manifestations and laboratory characteristics of pediatric severe fever with thrombocytopenia syndrome (SFTS) case caused by a novel bunyavirus. we retrospectively analyzed a pediatric case of viral SFTS in a 13 year old successfully managed and confirmed to be due to the novel bunyavirus now referred to as Huaiyangshan virus. A literature review of related cases was performed.Our pediatric case was a 13.3-year-old middle school student no underlying disease. Major clinical features included a fever with chills, headache, and dizziness...
2017: IDCases
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