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https://www.readbyqxmd.com/read/28512621/spontaneous-acute-subdural-hemorrhage-in-a-patient-with-a-tick-borne-bunyavirus-induced-severe-fever-with-thrombocytopenia-syndrome
#1
Jihwan Yoo, Ji Woong Oh, Chang Gi Jang, Ju Hyung Moon, Eui-Hyun Kim, Jong Hee Chang, Sun Ho Kim, Seok-Gu Kang
We report the first case of severe fever with thrombocytopenia syndrome (SFTS) and a spontaneous acute subdural hematoma (SDH) in Korea. A 79-year-old male presented with fever and thrombocytopenia. On the third day of hospitalization, his mental changed from drowsy to semi-coma. Brain computed tomography indicated an acute subdural hemorrhage on the right convexity. He was given early decompressive craniectomy, but did not survive. Real-time reverse transcription polymerase chain reaction analysis of a blood sample indicated the presence of SFTS virus (SFTSV)...
April 2017: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/28505175/structural-insights-into-reptarenavirus-cap-snatching-machinery
#2
Maria Rosenthal, Nadja Gogrefe, Dominik Vogel, Juan Reguera, Bianka Rauschenberger, Stephen Cusack, Stephan Günther, Sophia Reindl
Cap-snatching was first discovered in influenza virus. Structures of the involved domains of the influenza virus polymerase, namely the endonuclease in the PA subunit and the cap-binding domain in the PB2 subunit, have been solved. Cap-snatching endonucleases have also been demonstrated at the very N-terminus of the L proteins of mammarena-, orthobunya-, and hantaviruses. However, a cap-binding domain has not been identified in an arena- or bunyavirus L protein so far. We solved the structure of the 326 C-terminal residues of the L protein of California Academy of Sciences virus (CASV), a reptarenavirus, by X-ray crystallography...
May 15, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28497117/rna-interference-restricts-rift-valley-fever-virus-in-multiple-insect-systems
#3
Isabelle Dietrich, Stephanie Jansen, Gamou Fall, Stephan Lorenzen, Martin Rudolf, Katrin Huber, Anna Heitmann, Sabine Schicht, El Hadji Ndiaye, Mick Watson, Ilaria Castelli, Benjamin Brennan, Richard M Elliott, Mawlouth Diallo, Amadou A Sall, Anna-Bella Failloux, Esther Schnettler, Alain Kohl, Stefanie C Becker
The emerging bunyavirus Rift Valley fever virus (RVFV) is transmitted to humans and livestock by a large number of mosquito species. RNA interference (RNAi) has been characterized as an important innate immune defense mechanism used by mosquitoes to limit replication of positive-sense RNA flaviviruses and togaviruses; however, little is known about its role against negative-strand RNA viruses such as RVFV. We show that virus-specific small RNAs are produced in infected mosquito cells, in Drosophila melanogaster cells, and, most importantly, also in RVFV vector mosquitoes...
May 2017: MSphere
https://www.readbyqxmd.com/read/28496029/a-newly-established-severity-scoring-system-in-predicting-the-prognosis-of-patients-with-severe-fever-with-thrombocytopenia-syndrome
#4
Bo Yang, Xiaoli Wang, Yaping Li, Anzhao Wu, Qian Liu, Yuyin Lu, Chengmin Yuan, Mingming Wang
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by novel Bunyavirus. Due to the peculiarity of SFTS, accurate assessment is difficult to achieve with the current score systems. This study aimed to establish a new severity scoring system in predicting the prognosis of patients with SFTS. We included 123 patients with SFTS: 92 patients (45 males and 47 females), aged 59 ± 12 years, in survive group and 31 patients (17 males and 14 females), aged 61 ± 10 years, in death group...
May 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28479064/detection-of-a-novel-putative-phlebovirus-and-first-isolation-of-dugbe-virus-from-ticks-in-accra-ghana
#5
Daisuke Kobayashi, Mitsuko Ohashi, Joseph H N Osei, Esinam Agbosu, Millicent Opoku, Alfred Agbekudzi, Joannitta Joannides, Ryosuke Fujita, Toshinori Sasaki, J H Kofi Bonney, Samuel Dadzie, Haruhiko Isawa, Kyoko Sawabe, Nobuo Ohta
Ticks are ectoparasites that transmit various types of human and animal pathogens. In particular, emerging and re-emerging diseases caused by tick-borne viruses are public health concerns around the world. However, in many countries of the sub-Saharan African region, epidemiological information on tick-borne viral infections is limited, and their prevalence and distribution remain largely unknown. In this study, we conducted surveillance on ticks to detect medically important tick-borne bunyaviruses in three study sites in and near to Accra, the capital city of Ghana, in 2015...
April 23, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28418734/bunyaviridae-rdrps-structure-motifs-and-rna-synthesis-machinery
#6
Abdennour Amroun, Stéphane Priet, Xavier de Lamballerie, Gilles Quérat
Bunyaviridae family is the largest and most diverse family of RNA viruses. It has more than 350 members divided into five genera: Orthobunyavirus, Phlebovirus, Nairovirus, Hantavirus, and Tospovirus. They are present in the five continents, causing recurrent epidemics, epizootics, and considerable agricultural loss. The genome of bunyaviruses is divided into three segments of negative single-stranded RNA according to their relative size: L (Large), M (Medium) and S (Small) segment. Bunyaviridae RNA-dependent RNA polymerase (RdRp) is encoded by the L segment, and is in charge of the replication and transcription of the viral RNA in the cytoplasm of the infected cell...
April 18, 2017: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/28399161/seroprevalence-of-severe-fever-with-thrombocytopenia-syndrome-virus-in-china-a-systematic-review-and-meta-analysis
#7
Peng Li, Zhen-Dong Tong, Ke-Feng Li, An Tang, Ya-Xin Dai, Jian-Bo Yan
OBJECTIVE: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel bunyavirus-SFTSV. The seroprevalence of anti-SFTSV antibodies including immunoglobulin G (IgG) and immunoglobulin M (IgM), specific to SFTSV in the general population has been investigated in various epidemiological studies with inconsistent results. Here, we clarify this discrepancy and reach a more comprehensive result by mean of a meta-analysis. METHODS: All relevant articles were searched in the electronic databases (PubMed, Web of science, Embase, Chinese National Knowledge Infrastructure database, Chinese Wanfang database) up to November 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28388693/a-role-for-glycolipid-biosynthesis-in-severe-fever-with-thrombocytopenia-syndrome-virus-entry
#8
Mary Jane Drake, Benjamin Brennan, Kenneth Briley, Stephen M Bart, Eric Sherman, Agnieszka M Szemiel, Madeleine Minutillo, Frederic D Bushman, Paul Bates
A novel bunyavirus was recently found to cause severe febrile illness with high mortality in agricultural regions of China, Japan, and South Korea. This virus, named severe fever with thrombocytopenia syndrome virus (SFTSV), represents a new group within the Phlebovirus genus of the Bunyaviridae. Little is known about the viral entry requirements beyond showing dependence on dynamin and endosomal acidification. A haploid forward genetic screen was performed to identify host cell requirements for SFTSV entry...
April 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28323557/seroprevalence-of-severe-fever-with-thrombocytopenia-syndrome-virus-in-hedgehog-from-china
#9
Yue Sun, Miao-Miao Liu, Li-Mei Luo, Li Zhao, Hong-Ling Wen, Zhen-Tang Zhang, Jian-Wei Liu, Zai-Feng Xue, Dong-Qiang Ma, Shu-Jun Ding, Xiao-Ying Lei, Xue-Jie Yu
Severe fever with thrombocytopenia syndrome, an emerging hemorrhagic fever, is caused by severe fever with thrombocytopenia syndrome virus (SFTSV), a tick-borne bunyavirus. Information regarding SFTSV animal hosts is very limited. In this study, we showed that 64% (9/14) of hedgehogs in Shandong Province, China were seropositive to SFTSV antibody, suggesting that hedgehog could be a vertebrate parasitifer for SFTSV.
May 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28251516/isolation-characterization-and-phylogenic-analysis-of-three-new-severe-fever-with-thrombocytopenia-syndrome-bunyavirus-strains-derived-from-hubei-province-china
#10
Yanfang Zhang, Shu Shen, Junming Shi, Zhengyuan Su, Mingyue Li, Wenjing Zhang, Mengmeng Li, Zhihong Hu, Cheng Peng, Xin Zheng, Fei Deng
Hubei Province is a major epidemic area of severe fever with thrombocytopenia syndrome bunyavirus (SFTSV) in China. However, to date, a few SFTSV strains have been isolated from Hubei Province, preventing effective studies of epidemic outbreaks. Here, we report three confirmed patients (2015-2016) with typical symptoms of severe fever with thrombocytopenia syndrome disease (SFTS) who were farmers resident in different regions in Hubei Province. Three new SFTSV strains were isolated from the serum samples of each patient...
February 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28250124/immunization-with-dna-plasmids-coding-for-crimean-congo-hemorrhagic-fever-virus-capsid-and-envelope-proteins-and-or-virus-like-particles-induces-protection-and-survival-in-challenged-mice
#11
Jorma Hinkula, Stéphanie Devignot, Sara Åkerström, Helen Karlberg, Eva Wattrang, Sándor Bereczky, Mehrdad Mousavi-Jazi, Christian Risinger, Gunnel Lindegren, Caroline Vernersson, Janusz Paweska, Petrus Jansen van Vuren, Ola Blixt, Alejandro Brun, Friedemann Weber, Ali Mirazimi
Crimean-Congo hemorrhagic fever virus (CCHFV) is a bunyavirus causing severe hemorrhagic fever disease in humans, with high mortality rates. The requirement of a high-containment laboratory and the lack of an animal model hampered the study of the immune response and protection of vaccine candidates. Using the recently developed interferon alpha receptor knockout (IFNAR(-/-)) mouse model, which replicates human disease, we investigated the immunogenicity and protection of two novel CCHFV vaccine candidates: a DNA vaccine encoding a ubiquitin-linked version of CCHFV Gc, Gn, and N and one using transcriptionally competent virus-like particles (tc-VLPs)...
May 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28243938/hemorrhagic-fever-of-bunyavirus-etiology-disease-models-and-progress-towards-new-therapies
#12
REVIEW
Brian B Gowen, Brady T Hickerson
A growing number of bunyaviruses are known to cause viral hemorrhagic fever (VHF), a severe febrile illness which can progress to hypovolemic shock and multi-organ failure and is characterized by hematologic abnormalities and vascular leak. At present, there are no approved vaccines or antiviral therapies to effectively prevent or treat VHF caused by pathogenic bunyaviruses. Advances in the modeling of bunyaviral infections have facilitated efforts towards the development of novel post-exposure prophylactic and therapeutic countermeasures, several of which may some day be approved for human use...
March 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/28235558/dna-vaccination-regimes-against-schmallenberg-virus-infection-in-ifnar-mice-suggest-two-targets-for-immunization
#13
Hani Y Boshra, Diego Charro, Gema Lorenzo, Isbene Sánchez, Beatriz Lazaro, Alejandro Brun, Nicola G A Abrescia
Schmallenberg virus (SBV) is an RNA virus of the Bunyaviridae family, genus Orthobunyavirus that infects wild and livestock species of ruminants. While inactivated and attenuated vaccines have been shown to prevent SBV infection, little is known about their mode of immunity; specifically, which components of the virus are responsible for inducing immunological responses in the host. As previous DNA vaccination experiments on other bunyaviruses have found that glycoproteins, as well as modified (i.e. ubiquitinated) nucleoproteins (N) can confer immunity against virulent viral challenge, constructs encoding for fragments of SBV glycoproteins GN and GC, as well as ubiquitinated and non-ubiquitinated N were cloned in mammalian expression vectors, and vaccinated intramuscularly in IFNAR(-/-) mice...
February 21, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28209840/genome-sequences-of-three-novel-bunyaviruses-two-novel-rhabdoviruses-and-one-novel-nyamivirus-from-washington-state-moths
#14
Negar Makhsous, Ryan C Shean, David Droppers, Jonathan Guan, Keith R Jerome, Alexander L Greninger
We report draft genome sequences of three novel bunyaviruses, two novel rhabdoviruses, and one novel nyamivirus identified metagenomically from 10 moths in Washington state.
February 16, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28202038/establishment-of-national-reference-for-bunyavirus-nucleic-acid-detection-kits-for-diagnosis-of-sfts-virus
#15
Xu Lu, Ling Wang, Dongting Bai, Yuhua Li
BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) caused by SFTS virus (SFTSV) usually have a high fatality. At present no effective therapy or vaccine are available, so early diagnosis of SFTS is crucial to prevent and control SFTSV infection. This study aimed to establish a national reference for these diagnostic kits of SFTSV genome and make the diagnosis of the disease effective. METHODS: Six SFTSV strains isolated from different regions, and five relative viruses with similar clinical manifestations were selected as positive and negative references and assessed using real time quantitative PCR (q-PCR) using specific primers and probe and two commercial kits...
February 16, 2017: Virology Journal
https://www.readbyqxmd.com/read/28153792/mosquito-borne-viruses-circulating-in-kinshasa-democratic-republic-of-the-congo
#16
Kennedy Makola Mbanzulu, Roger Wumba, Jean-Pierre Kambala Mukendi, Josué Kikana Zanga, Fortunate Shija, Thierry Lengu Bobanga, Michel Ntetani Aloni, Gerald Misinzo
BACKGROUND: Diseases caused by mosquito-borne viruses are among the most important emerging diseases that threaten human and animal health, particularly in Africa. However, little attention has been paid to these diseases in the Democratic Republic of the Congo (DRC). The present cross-sectional study was undertaken between March and May 2014 to investigate the presence of mosquito-borne viruses in mosquitoes collected from five municipalities of Kinshasa, DRC. METHODS: Mosquitoes were collected using BG-Sentinel traps and battery-powered aspirators...
April 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28137457/transcription-and-replication-mechanisms-of-bunyaviridae-and-arenaviridae-l-proteins
#17
REVIEW
François Ferron, Friedemann Weber, Juan Carlos de la Torre, Juan Reguera
Bunyaviridae and Arenaviridae virus families include an important number of highly pathogenic viruses for humans. They are enveloped viruses with negative stranded RNA genomes divided into three (bunyaviruses) or two (arenaviruses) segments. Each genome segment is coated by the viral nucleoproteins (NPs) and the polymerase (L protein) to form a functional ribonucleoprotein (RNP) complex. The viral RNP provides the necessary context on which the L protein carries out the biosynthetic processes of RNA replication and gene transcription...
January 27, 2017: Virus Research
https://www.readbyqxmd.com/read/28111322/new-bunya-like-viruses-highlighting-their-relations
#18
Alexandro Guterres, Renata Carvalho de Oliveira, Jorlan Fernandes, Elba Regina Sampaio de Lemos, Carlos Guerra Schrago
The standard virus classification scheme for arenaviruses and bunyaviruses shifted dramatically when several groups reported the detection and isolation of divergent groups of viruses in a variety of insect collections. Although these viral families can differ in terms of morphology, structure and genetics, recent findings indicate these viruses may have a shared evolutionary origin. To determine the phylogenetic relations among these families, we inferred phylogenetic trees using three methods. The Maximum Likelihood and Bayesian trees were rooted as suggested by the (molecular clock-rooted) BEAST tree...
January 19, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28106111/broad-range-antiviral-activity-of-hydrogen-sulfide-against-highly-pathogenic-rna-viruses
#19
Nikolay Bazhanov, Olivier Escaffre, Alexander N Freiberg, Roberto P Garofalo, Antonella Casola
Hydrogen sulfide is an important endogenous mediator that has been the focus of intense investigation in the past few years, leading to the discovery of its role in vasoactive, cytoprotective and anti-inflammatory responses. Recently, we made a critical observation that H2S also has a protective role in paramyxovirus infection by modulating inflammatory responses and viral replication. In this study we tested the antiviral and anti-inflammatory activity of the H2S slow-releasing donor GYY4137 on enveloped RNA viruses from Ortho-, Filo-, Flavi- and Bunyavirus families, for which there is no FDA-approved vaccine or therapeutic available, with the exception of influenza...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28088586/a-case-control-study-of-risk-sources-for-severe-fever-with-thrombocytopenia-syndrome-in-hubei-province-china
#20
Xuesen Xing, Xuhua Guan, Li Liu, Junqiang Xu, Guoming Li, Jianbo Zhan, Gongping Liu, Xiaoqing Jiang, Xingfu Shen, Yongzhong Jiang, Yang Wu, Hao Zhang, Jing Huang, Fan Ding, Sha Sha, Man Liu, Faxian Zhan
BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS), an emerging infectious disease caused by a novel bunyavirus, was discovered in rural areas of Central China in 2009. METHODS: A case-control study based on hospital data was applied to detect the potential risk sources for SFTS in SFTS-endemic counties in Hubei Province. Cases were defined as hospitalized SFTSV confirmed patients. Controls were randomly selected from non-SFTSV patients in the same hospital ward within 2 weeks of inclusion of the cases, and they were matched by age (+/- 5 years) and gender according to 1:2 matching condition...
February 2017: International Journal of Infectious Diseases: IJID
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