keyword
MENU ▼
Read by QxMD icon Read
search

Bunyavirus

keyword
https://www.readbyqxmd.com/read/28088586/a-case-control-study-of-risk-sources-for-severe-fever-with-thrombocytopenia-syndrome-in-hubei-province-china
#1
Xuesen Xing, Xuhua Guan, Li Liu, Junqiang Xu, Guoming Li, Jianbo Zhan, Gongping Liu, Xiaoqing Jiang, Xingfu Shen, Yongzhong Jiang, Yang Wu, Hao Zhang, Jing Huang, Fan Ding, Sha Sha, Man Liu, Faxian Zhan
BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS), an emerging infectious disease caused by a novel bunyavirus, was discovered in rural areas of Central China in 2009. METHODS: A case-control study based on hospital data was applied to detect the potential risk sources for SFTS in SFTS-endemic counties in Hubei Province. Cases were defined as hospitalized SFTSV confirmed patients. Controls were randomly selected from non-SFTSV patients in the same hospital ward within 2 weeks of inclusion of the cases, and they were matched by age (+/- 5 years) and gender according to 1:2 matching condition...
January 11, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28086978/correlation-of-cytokine-level-with-the-severity-of-severe-fever-with-thrombocytopenia-syndrome
#2
Miao-Miao Liu, Xiao-Ying Lei, Hao Yu, Jian-Zhi Zhang, Xue-Jie Yu
BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) was an emerging hemorrhagic fever that was caused by a tick-borne bunyavirus, SFTSV. Although SFTSV nonstructural protein can inhibit type I interferon (IFN-I) production Ex Vivo and IFN-I played key role in resistance SFTSV infection in animal model, the role of IFN-I in patients is not investigated. METHODS: We have assayed the concentration of IFN-α, a subtype of IFN-I as well as other cytokines in the sera of SFTS patients and the healthy population with CBA (Cytometric bead array) assay...
January 13, 2017: Virology Journal
https://www.readbyqxmd.com/read/28060823/the-antiviral-rnai-response-in-vector-and-non-vector-cells-against-orthobunyaviruses
#3
Isabelle Dietrich, Xiaohong Shi, Melanie McFarlane, Mick Watson, Anne-Lie Blomström, Jessica K Skelton, Alain Kohl, Richard M Elliott, Esther Schnettler
BACKGROUND: Vector arthropods control arbovirus replication and spread through antiviral innate immune responses including RNA interference (RNAi) pathways. Arbovirus infections have been shown to induce the exogenous small interfering RNA (siRNA) and Piwi-interacting RNA (piRNA) pathways, but direct antiviral activity by these host responses in mosquito cells has only been demonstrated against a limited number of positive-strand RNA arboviruses. For bunyaviruses in general, the relative contribution of small RNA pathways in antiviral defences is unknown...
January 6, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28043784/snail-shells-as-larval-habitat-of-limatus-durhamii-diptera-culicidae-in-the-yungas-of-argentina
#4
Carolina Mangudo, Raúl E Campos, Gustavo C Rossi, Raquel M Gleiser
The shells of dead snails collect water from rainfalls producing aquatic microenvironments called gastrotelmata. These habitats are small and hold simple detritus based on animal communities, being rotifers and culicids the most studied. Although a high diversity of aquatic microhabitats has been reported as larval habitats of mosquitoes in Argentina, the shell of snails has not been investigated yet. We report the shells of three species of native Megalobulimus genus as larval habitats of a neotropical mosquito and suspected vector of bunyaviruses, Limatus durhamii, and describe these microhabitats in the Yungas forest of Argentina...
December 30, 2016: Acta Tropica
https://www.readbyqxmd.com/read/28036115/development-and-validation-of-a-real-time-reverse-transcriptase-pcr-assay-for-sensitive-detection-of-sftsv
#5
Peibin Zeng, Zhendong Yang, Sonia Bakkour, Bingjun Wang, Shuli Qing, Jingxing Wang, Limin Chen, Michael Busch, Hua Shan, Jing Liu, Tzong-Hae Lee
BACKGROUND: Severe fever with thrombocytopenia syndrome bunyavirus (SFTSV) is an emerging tick-borne RNA virus recently identified as the pathogen that causes severe fever with thrombocytopenia syndrome (SFTS) in China. The existing commercial nucleic acid testing (comNAT) assay with a relatively high claimed limit of quantitative detection (LOQD) is not capable of sensitive detection and quantitation of SFTSV. Thus, a new real-time reverse transcriptase (RT)-PCR assay with improved sensitivity is needed for clinical diagnosis; it could also be used to screen blood donors if necessary...
December 30, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/28007850/genome-sequences-of-a-novel-vietnamese-bat-bunyavirus
#6
Bas B Oude Munnink, My V T Phan, Lia van der Hoek, Paul Kellam, Matthew Cotten
To document the viral zoonotic risks in Vietnam, fecal samples were systematically collected from a number of mammals in southern Vietnam and subjected to agnostic deep sequencing. We describe here novel Vietnamese bunyavirus sequences detected in bat feces. The complete L and S segments from 14 viruses were determined.
December 22, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27995422/entry-of-severe-fever-with-thrombocytopenia-syndrome-virus
#7
REVIEW
Fei Yuan, Aihua Zheng
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a globe-shaped virus covered by a dense icosahedral array of glycoproteins Gn/Gc that mediate the attachment of the virus to host cells and the fusion of viral and cellular membranes. Several membrane factors are involved in virus entry, including C-type lectins and nonmuscle myosin heavy chain IIA. The post-fusion crystal structure of the Gc protein suggests that it is a class II membrane fusion protein, similar to the E/E1 protein of flaviviruses and alphaviruses...
December 16, 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27979594/synthesis-and-in-vitro-antiviral-evaluation-of-4-substituted-3-4-dihydropyrimidinones
#8
Dhanabal Kumarasamy, Biswajit Gopal Roy, Joana Rocha-Pereira, Johan Neyts, Satheeshkumar Nanjappan, Subhasis Maity, Musfiqua Mookerjee, Lieve Naesens
A series of 4-substituted 3,4-dihydropyrimidine-2-ones (DHPM) was synthesized, characterized by IR, (1)H NMR, (13)C NMR and HRMS spectra. The compounds were evaluated in vitro for their antiviral activity against a broad range of DNA and RNA viruses, along with assessment for potential cytotoxicity in diverse mammalian cell lines. Compound 4m, which possesses a long lipophilic side chain, was found to be a potent and selective inhibitor of Punta Toro virus, a member of the Bunyaviridae. For Rift Valley fever virus, which is another Bunyavirus, the activity of 4m was negligible...
January 15, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27915109/decreased-myeloid-dendritic-cells-indicate-a-poor-prognosis-in-patients-with-severe-fever-with-thrombocytopenia-syndrome
#9
Wenjing Zhang, Mengmeng Li, Shue Xiong, Hua Wang, Yan Xiong, Mingyue Li, Mengji Lu, Dongliang Yang, Cheng Peng, Xin Zheng
OBJECTIVES: Severe fever with thrombocytopenia syndrome (SFTS) is a newly emerging infectious disease caused by a novel bunyavirus in which host immune system suppression is thought to be crucial in the development of disease. This study was designed to study the frequencies and activation status of dendritic cells (DCs) at different stages of SFTS and their association with disease severity. METHODS: All confirmed SFTS patients (N=115) were recruited from the Wuhan Union Hospital in 2015; routine laboratory parameters were collected...
January 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27899121/meta-analysis-of-the-clinical-and-laboratory-parameters-of-sfts-patients-in-china
#10
Miao-Miao Liu, Xiao-Ying Lei, Xue-Jie Yu
BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever in East Asia, which is caused by a novel bunyavirus-SFTSV. Many studies have reported the clinical characters of SFTS patients, but the reports were not consistent and a systematic summary of clinical manifestations and laboratory parameters are not available. METHOD: A comprehensive literature research of Web of Science, PubMed, Wan Fang Data, and Chinese National Knowledge Infrastructure databases was conducted on articles which have described the clinical characters of SFTS patients...
November 29, 2016: Virology Journal
https://www.readbyqxmd.com/read/27899013/in-vitro-antiviral-activity-of-ribavirin-against-severe-fever-with-thrombocytopenia-syndrome-virus
#11
Myung Jin Lee, Kye-Hyung Kim, Jongyoun Yi, Su Jin Choi, Pyoeng Gyun Choe, Wan Beom Park, Nam Joong Kim, Myoung-Don Oh
Background/Aims: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by severe fever with thrombocytopenia syndrome virus (SFTSV), a novel bunyavirus. As yet, there is no effective antiviral therapy for SFTS. Ribavirin is a broad-spectrum antiviral agent, which has been tried for treatment of SFTS. In this study, antiviral activity of ribavirin against SFTSV has been investigated. Methods: Vero cell-grown SFTSV strain Gangwon/Korea/2012 was treated with ribavirin at various concentrations...
November 30, 2016: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/27884653/migration-recombination-and-reassortment-are-involved-in-the-evolution-of-severe-fever-with-thrombocytopenia-syndrome-bunyavirus
#12
Junming Shi, Sheng Hu, Xiaoping Liu, Juan Yang, Dan Liu, Liang Wu, Hualin Wang, Zhihong Hu, Fei Deng, Shu Shen
Severe fever with thrombocytopenia syndrome bunyavirus (SFTSV) has been identified as the etiological agent causing severe fever with thrombocytopenia syndrome (SFTS). SFTSV was reported in recent years as a newly emerging tick-borne virus in China, Japan and South Korea and is a novel member of the genus Phlebovirus, family Bunyaviridae, which is suspected to be transmitted by the tick Haemaphysalis longicornis. The genetic diversity and evolutionary relationships between geographically distributed SFTSV strains are currently unclear...
January 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27883371/severe-fever-with-thrombocytopenia-syndrome-presenting-with-hemophagocytic-lymphohistiocytosis
#13
Jongmin Lee, Gyeongmin Jeong, Ji Hun Lim, Hawk Kim, Sun Whan Park, Won Ja Lee, Jae Bum Jun
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease caused by the newly discovered SFTS Bunyavirus, and there have been no case reports of SFTS patients presenting with hemophagocytic lymphohistiocytosis (HLH) in the English literature. We report a case of SFTS presenting with HLH in a 73-year-old immunocompetent male farmer. Although the patient had poor prognostic factors for SFTS, such as old age and central nervous system symptoms, he recovered fully with supportive care...
December 2016: Infection & Chemotherapy
https://www.readbyqxmd.com/read/27855227/evidence-that-processing-of-the-severe-fever-with-thrombocytopenia-syndrome-virus-gn-gc-polyprotein-is-critical-for-viral-infectivity-and-requires-an-internal-gc-signal-peptide
#14
Teresa Plegge, Heike Hofmann-Winkler, Martin Spiegel, Stefan Pöhlmann
The severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging, highly pathogenic bunyavirus against which neither antivirals nor vaccines are available. The SFTSV glycoproteins, Gn and Gc, facilitate viral entry into host cells. Gn and Gc are generated from a precursor protein, Gn/Gc, but it is currently unknown how the precursor is converted into the single proteins and whether this process is required for viral infectivity. Employing a rhabdoviral pseudotyping system, we demonstrate that a predicted signal sequence at the N-terminus of Gc is required for Gn/Gc processing and viral infectivity while potential proprotein convertase cleavage sites in Gc are dispensable...
2016: PloS One
https://www.readbyqxmd.com/read/27846273/risk-factors-for-bunyavirus-associated-severe-fever-with-thrombocytopenia-syndrome-a-community-based-case-control-study
#15
Jian-Li Hu, Zhi-Feng Li, Xiao-Chen Wang, Lei Hong, Hao He, Wei-Guo Chen, Lu-Xun Li, Ai-Hua Shen, Xue-Jian Liu, Shou-Guo Yuan, Jian-Gang Zhou, Wen-Wen Tan, Wei-Zhong Zhou, Fen-Yang Tang, Feng-Cai Zhu, Chang-Jun Bao
BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel bunyavirus. Previous studies about risk factors for SFTSV infection have yielded inconsistent results, and behavior factors have not been fully clarified. METHODS: A community-based, 1:4 matched case-control study was carried out to investigate the risk factors for SFTS in China. Cases of SFTS were defined as laboratory-confirmed cases that tested positive for real-time PCR (RT-PCR) for severe fever with thrombocytopenia syndrome bunyavirus (SFTSV) or positive for IgM antibodies against SFTSV...
2016: PloS One
https://www.readbyqxmd.com/read/27802822/retraction-note-neuropathological-microscopic-features-of-abortions-induced-by-bunyavirus-or-flavivirus-infections
#16
Javad Javanbakht, Seyed Hossein Mardjanmehr, Abbas Tavasoly, Mohammad Hossein Nazemshirazi
No abstract text is available yet for this article.
November 2, 2016: Diagnostic Pathology
https://www.readbyqxmd.com/read/27783711/mechanistic-insight-into-bunyavirus-induced-membrane-fusion-from-structure-function-analyses-of-the-hantavirus-envelope-glycoprotein-gc
#17
Pablo Guardado-Calvo, Eduardo A Bignon, Eva Stettner, Scott Allen Jeffers, Jimena Pérez-Vargas, Gerard Pehau-Arnaudet, M Alejandra Tortorici, Jean-Luc Jestin, Patrick England, Nicole D Tischler, Félix A Rey
Hantaviruses are zoonotic viruses transmitted to humans by persistently infected rodents, giving rise to serious outbreaks of hemorrhagic fever with renal syndrome (HFRS) or of hantavirus pulmonary syndrome (HPS), depending on the virus, which are associated with high case fatality rates. There is only limited knowledge about the organization of the viral particles and in particular, about the hantavirus membrane fusion glycoprotein Gc, the function of which is essential for virus entry. We describe here the X-ray structures of Gc from Hantaan virus, the type species hantavirus and responsible for HFRS, both in its neutral pH, monomeric pre-fusion conformation, and in its acidic pH, trimeric post-fusion form...
October 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27767907/neutralizing-antibodies-to-severe-fever-with-thrombocytopenia-syndrome-virus-4-years-after-hospitalization-china
#18
Yu-Ting Huang, Li Zhao, Hong-Ling Wen, Yi Yang, Hao Yu, Xue-Jie Yu
Severe fever with thrombocytopenia syndrome is an emerging hemorrhagic fever disease in eastern Asia, caused by a tickborne bunyavirus. Of 25 patients hospitalized with this disease in China, 100% produced and maintained neutralizing antibodies to severe fever with thrombocytopenia syndrome virus for the study period of 4 years.
November 2016: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27764175/analysis-of-arbovirus-isolates-from-australia-identifies-novel-bunyaviruses-including-a-mapputta-group-virus-from-western-australia-that-links-gan-gan-and-maprik-viruses
#19
Thomas Briese, David T Williams, Vishal Kapoor, Sinead M Diviney, Andrea Certoma, Jianning Wang, Cheryl A Johansen, Rashmi Chowdhary, John S Mackenzie, W Ian Lipkin
The Mapputta group comprises antigenically related viruses indigenous to Australia and Papua New Guinea that are included in the family Bunyaviridae but not currently assigned to a specific genus. We determined and analyzed the genome sequences of five Australian viruses isolated from mosquitoes collected during routine arbovirus surveillance in Western Australia (K10441, SW27571, K13190, and K42904) and New South Wales (12005). Based on matching sequences of all three genome segments to prototype MRM3630 of Trubanaman virus (TRUV), NB6057 of Gan Gan virus (GGV), and MK7532 of Maprik virus (MPKV), isolates K13190 and SW27571 were identified as TRUV, 12005 as GGV, and K42904 as a Mapputta group virus from Western Australia linking GGV and MPKV...
2016: PloS One
https://www.readbyqxmd.com/read/27760141/correlation-between-hla-a-b-and-drb1-alleles-and-severe-fever-with-thrombocytopenia-syndrome
#20
Shu-Jun Ding, Yi Zhang, Xiao-Mei Zhang, Xiao-Lin Jiang, Bo Pang, Yong-Hong Song, Jian-Xing Wang, Yao-Wen Pei, Chuan-Fu Zhu, Xian-Jun Wang, Xue-Jie Yu
OBJECTIVE: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever caused by a tick-borne bunyavirus (SFTSV) in East Asian countries. The role of human leukocyte antigen (HLA) in resistance and susceptibility to SFTSV is not known. We investigated the correlation of HLA locus A, B and DRB1 alleles with the occurrence of SFTS. METHODS: A total of 84 confirmed SFTS patients (patient group) and 501 unrelated non-SFTS patients (healthy individuals as control group) from Shandong Province were genotyped by PCR-sequence specific oligonucleotide probe (PCR-SSOP) for HLA-A, B and DRB1 loci...
October 2016: PLoS Neglected Tropical Diseases
keyword
keyword
52429
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"