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https://www.readbyqxmd.com/read/27915109/decreased-myeloid-dendritic-cells-indicate-a-poor-prognosis-of-severe-fever-with-thrombocytopenia-syndrome-patients
#1
Wenjing Zhang, Mengmeng Li, Shue Xiong, Hua Wang, Yan Xiong, Mingyue Li, Mengji Lu, DongliangYang, Cheng Peng, Xin Zheng
OBJECTIVES: Severe fever with thrombocytopenia syndrome (SFTS) is a newly emerging infectious disease caused by a novel Bunyavirus in which host immune system suppression is thought to be crucial in the development of disease. The study is designed to study the frequencies and activation status of dendritic cells(DCs) at different stages of SFTS and its association with the disease severity. METHODS: All confirmed 115 SFTS patients were recruited from the Wuhan Union Hospital in 2015 and routine laboratory parameters were collected...
November 30, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27899121/meta-analysis-of-the-clinical-and-laboratory-parameters-of-sfts-patients-in-china
#2
Miao-Miao Liu, Xiao-Ying Lei, Xue-Jie Yu
BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever in East Asia, which is caused by a novel bunyavirus-SFTSV. Many studies have reported the clinical characters of SFTS patients, but the reports were not consistent and a systematic summary of clinical manifestations and laboratory parameters are not available. METHOD: A comprehensive literature research of Web of Science, PubMed, Wan Fang Data, and Chinese National Knowledge Infrastructure databases was conducted on articles which have described the clinical characters of SFTS patients...
November 29, 2016: Virology Journal
https://www.readbyqxmd.com/read/27899013/in-vitro-antiviral-activity-of-ribavirin-against-severe-fever-with-thrombocytopenia-syndrome-virus
#3
Myung Jin Lee, Kye-Hyung Kim, Jongyoun Yi, Su Jin Choi, Pyoeng Gyun Choe, Wan Beom Park, Nam Joong Kim, Myoung-Don Oh
Background/Aims: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by severe fever with thrombocytopenia syndrome virus (SFTSV), a novel bunyavirus. As yet, there is no effective antiviral therapy for SFTS. Ribavirin is a broad-spectrum antiviral agent, which has been tried for treatment of SFTS. In this study, antiviral activity of ribavirin against SFTSV has been investigated. Methods: Vero cell-grown SFTSV strain Gangwon/Korea/2012 was treated with ribavirin at various concentrations...
November 30, 2016: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/27884653/migration-recombination-and-reassortment-are-involved-in-the-evolution-of-severe-fever-with-thrombocytopenia-syndrome-bunyavirus
#4
Junming Shi, Sheng Hu, Xiaoping Liu, Juan Yang, Dan Liu, Liang Wu, Hualin Wang, Zhihong Hu, Fei Deng, Shu Shen
Severe fever with thrombocytopenia syndrome bunyavirus (SFTSV) has been identified as the etiological agent causing severe fever with thrombocytopenia syndrome (SFTS). SFTSV was reported in recent years as a newly emerging tick-borne virus in China, Japan and South Korea and is a novel member of the genus Phlebovirus, family Bunyaviridae, which is suspected to be transmitted by the tick Haemaphysalis longicornis. The genetic diversity and evolutionary relationships between geographically distributed SFTSV strains are currently unclear...
November 21, 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27883371/severe-fever-with-thrombocytopenia-syndrome-presenting-with-hemophagocytic-lymphohistiocytosis
#5
Jongmin Lee, Gyeongmin Jeong, Ji Hun Lim, Hawk Kim, Sun Whan Park, Won Ja Lee, Jae Bum Jun
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease caused by the newly discovered SFTS Bunyavirus, and there have been no case reports of SFTS patients presenting with hemophagocytic lymphohistiocytosis (HLH) in the English literature. We report a case of SFTS presenting with HLH in a 73-year-old immunocompetent male farmer. Although the patient had poor prognostic factors for SFTS, such as old age and central nervous system symptoms, he recovered fully with supportive care...
November 11, 2016: Infection & Chemotherapy
https://www.readbyqxmd.com/read/27855227/evidence-that-processing-of-the-severe-fever-with-thrombocytopenia-syndrome-virus-gn-gc-polyprotein-is-critical-for-viral-infectivity-and-requires-an-internal-gc-signal-peptide
#6
Teresa Plegge, Heike Hofmann-Winkler, Martin Spiegel, Stefan Pöhlmann
The severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging, highly pathogenic bunyavirus against which neither antivirals nor vaccines are available. The SFTSV glycoproteins, Gn and Gc, facilitate viral entry into host cells. Gn and Gc are generated from a precursor protein, Gn/Gc, but it is currently unknown how the precursor is converted into the single proteins and whether this process is required for viral infectivity. Employing a rhabdoviral pseudotyping system, we demonstrate that a predicted signal sequence at the N-terminus of Gc is required for Gn/Gc processing and viral infectivity while potential proprotein convertase cleavage sites in Gc are dispensable...
2016: PloS One
https://www.readbyqxmd.com/read/27846273/risk-factors-for-bunyavirus-associated-severe-fever-with-thrombocytopenia-syndrome-a-community-based-case-control-study
#7
Jian-Li Hu, Zhi-Feng Li, Xiao-Chen Wang, Lei Hong, Hao He, Wei-Guo Chen, Lu-Xun Li, Ai-Hua Shen, Xue-Jian Liu, Shou-Guo Yuan, Jian-Gang Zhou, Wen-Wen Tan, Wei-Zhong Zhou, Fen-Yang Tang, Feng-Cai Zhu, Chang-Jun Bao
BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel bunyavirus. Previous studies about risk factors for SFTSV infection have yielded inconsistent results, and behavior factors have not been fully clarified. METHODS: A community-based, 1:4 matched case-control study was carried out to investigate the risk factors for SFTS in China. Cases of SFTS were defined as laboratory-confirmed cases that tested positive for real-time PCR (RT-PCR) for severe fever with thrombocytopenia syndrome bunyavirus (SFTSV) or positive for IgM antibodies against SFTSV...
2016: PloS One
https://www.readbyqxmd.com/read/27802822/retraction-note-neuropathological-microscopic-features-of-abortions-induced-by-bunyavirus-or-flavivirus-infections
#8
Javad Javanbakht, Seyed Hossein Mardjanmehr, Abbas Tavasoly, Mohammad Hossein Nazemshirazi
No abstract text is available yet for this article.
November 2, 2016: Diagnostic Pathology
https://www.readbyqxmd.com/read/27783711/mechanistic-insight-into-bunyavirus-induced-membrane-fusion-from-structure-function-analyses-of-the-hantavirus-envelope-glycoprotein-gc
#9
Pablo Guardado-Calvo, Eduardo A Bignon, Eva Stettner, Scott Allen Jeffers, Jimena Pérez-Vargas, Gerard Pehau-Arnaudet, M Alejandra Tortorici, Jean-Luc Jestin, Patrick England, Nicole D Tischler, Félix A Rey
Hantaviruses are zoonotic viruses transmitted to humans by persistently infected rodents, giving rise to serious outbreaks of hemorrhagic fever with renal syndrome (HFRS) or of hantavirus pulmonary syndrome (HPS), depending on the virus, which are associated with high case fatality rates. There is only limited knowledge about the organization of the viral particles and in particular, about the hantavirus membrane fusion glycoprotein Gc, the function of which is essential for virus entry. We describe here the X-ray structures of Gc from Hantaan virus, the type species hantavirus and responsible for HFRS, both in its neutral pH, monomeric pre-fusion conformation, and in its acidic pH, trimeric post-fusion form...
October 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27767907/neutralizing-antibodies-to-severe-fever-with-thrombocytopenia-syndrome-virus-4-years-after-hospitalization-china
#10
Yu-Ting Huang, Li Zhao, Hong-Ling Wen, Yi Yang, Hao Yu, Xue-Jie Yu
Severe fever with thrombocytopenia syndrome is an emerging hemorrhagic fever disease in eastern Asia, caused by a tickborne bunyavirus. Of 25 patients hospitalized with this disease in China, 100% produced and maintained neutralizing antibodies to severe fever with thrombocytopenia syndrome virus for the study period of 4 years.
November 2016: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27764175/analysis-of-arbovirus-isolates-from-australia-identifies-novel-bunyaviruses-including-a-mapputta-group-virus-from-western-australia-that-links-gan-gan-and-maprik-viruses
#11
Thomas Briese, David T Williams, Vishal Kapoor, Sinead M Diviney, Andrea Certoma, Jianning Wang, Cheryl A Johansen, Rashmi Chowdhary, John S Mackenzie, W Ian Lipkin
The Mapputta group comprises antigenically related viruses indigenous to Australia and Papua New Guinea that are included in the family Bunyaviridae but not currently assigned to a specific genus. We determined and analyzed the genome sequences of five Australian viruses isolated from mosquitoes collected during routine arbovirus surveillance in Western Australia (K10441, SW27571, K13190, and K42904) and New South Wales (12005). Based on matching sequences of all three genome segments to prototype MRM3630 of Trubanaman virus (TRUV), NB6057 of Gan Gan virus (GGV), and MK7532 of Maprik virus (MPKV), isolates K13190 and SW27571 were identified as TRUV, 12005 as GGV, and K42904 as a Mapputta group virus from Western Australia linking GGV and MPKV...
2016: PloS One
https://www.readbyqxmd.com/read/27760141/correlation-between-hla-a-b-and-drb1-alleles-and-severe-fever-with-thrombocytopenia-syndrome
#12
Shu-Jun Ding, Yi Zhang, Xiao-Mei Zhang, Xiao-Lin Jiang, Bo Pang, Yong-Hong Song, Jian-Xing Wang, Yao-Wen Pei, Chuan-Fu Zhu, Xian-Jun Wang, Xue-Jie Yu
OBJECTIVE: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever caused by a tick-borne bunyavirus (SFTSV) in East Asian countries. The role of human leukocyte antigen (HLA) in resistance and susceptibility to SFTSV is not known. We investigated the correlation of HLA locus A, B and DRB1 alleles with the occurrence of SFTS. METHODS: A total of 84 confirmed SFTS patients (patient group) and 501 unrelated non-SFTS patients (healthy individuals as control group) from Shandong Province were genotyped by PCR-sequence specific oligonucleotide probe (PCR-SSOP) for HLA-A, B and DRB1 loci...
October 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27720055/evolutionary-origin-of-pathogenic-arthropod-borne-viruses-a-case-study-in-the-family-bunyaviridae
#13
Sandra Junglen
Arthropod-borne viruses have a dual-host tropism and their transmission requires the infection of two disparate hosts, arthropods and vertebrates. Arboviruses occur in several RNA families that also contain viruses with a monotropism for either arthropods or vertebrates. The evolutionary origin of the dual-host tropism of arboviruses was recently identified for the family Bunyaviridae. Bunyaviruses were suggested to have evolved from viruses that are restricted to arthropods as hosts (arthropod-specific viruses)...
August 2016: Current Opinion in Insect Science
https://www.readbyqxmd.com/read/27692043/wolbachia-restricts-insect-specific-flavivirus-infection-in-aedes-aegypti-cells
#14
Esther Schnettler, Vatipally B Sreenu, Timothy Mottram, Melanie McFarlane
Mosquito-borne viruses are known to cause disease in humans and livestock and are often difficult to control due to the lack of specific antivirals and vaccines. The Wolbachia endosymbiont has been widely studied for its ability to restrict positive-strand RNA virus infection in mosquitoes, although little is known about the precise antiviral mechanism. In recent years, a variety of insect-specific viruses have been discovered in mosquitoes and an interaction with mosquito-borne viruses has been reported for some of them; however, nothing is known about the effect of Wolbachia on insect-specific virus infection in mosquitoes...
November 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27648639/accuracy-of-diagnosis-of-human-granulocytic-anaplasmosis-in-china
#15
Gary P Wormser
In 2008, human granulocytic anaplasmosis (HGA) was reported from China. However, the clinical and laboratory findings, including reports of nosocomial transmission, were inconsistent with those reported for HGA in the United States. In 2012, it was demonstrated that the patients described in the 2008 report had all been infected with a newly discovered bunyavirus, severe fever with thrombocytopenia syndrome virus, which causes an illness with the same clinical features described for the patients in the 2008 report...
October 2016: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27619058/complete-genome-characterisation-and-phylogenetic-position-of-tigray-hantavirus-from-the-ethiopian-white-footed-mouse-stenocephalemys-albipes
#16
Joëlle Goüy de Bellocq, Jana Těšíková, Yonas Meheretu, Dagmar Čížková, Anna Bryjová, Herwig Leirs, Josef Bryja
Hantaviruses, well-known human pathogens, have only recently been identified on the African continent. Tigray virus (TIGV) was found in Ethiopia in 2012 in a Murinae species, Stenocephalemys albipes, but the genetic data obtained at that time were too limited to correctly assess its phylogenetic position within the hantavirus tree. We used high throughput sequencing to determine the complete genome of TIGV, which showed a typical hantavirus organisation. The large (L), medium (M), and small (S) genome segments were found to be 6532, 3594 and 1908 nucleotides long, respectively, and the 5' and 3' termini for all three segments were predicted to form the panhandle-like structure typical for bunyaviruses...
September 9, 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27602290/bunyaviruses-are-common-in-male-and-female-ixodes-scapularis-ticks-in-central-pennsylvania
#17
Joyce M Sakamoto, Terry Fei Fan Ng, Yasutsugu Suzuki, Hitoshi Tsujimoto, Xutao Deng, Eric Delwart, Jason L Rasgon
The blacklegged tick Ixodes scapularis is widely distributed in the United States and transmits multiple pathogens to humans, wildlife and domestic animals. Recently, several novel viruses in the family Bunyaviridae (South Bay virus (SBV) and Blacklegged tick phlebovirus (BTPV)) were identified infecting female I. scapularis ticks collected in New York State. We used metagenomic sequencing to investigate the distribution of viruses infecting male and female I. scapularis ticks collected in Centre County, Pennsylvania...
2016: PeerJ
https://www.readbyqxmd.com/read/27578436/the-genus-tospovirus-emerging-bunyaviruses-that-threaten-food-security
#18
J E Oliver, A E Whitfield
The genus Tospovirus is unique within the family Bunyaviridae in that it is made up of viruses that infect plants. Initially documented over 100 years ago, tospoviruses have become increasingly important worldwide since the 1980s due to the spread of the important insect vector Frankliniella occidentalis and the discovery of new viruses. As a result, tospoviruses are now recognized globally as emerging agricultural diseases. Tospoviruses and their vectors, thrips species in the order Thysanoptera, represent a major problem for agricultural and ornamental crops that must be managed to avoid devastating losses...
September 29, 2016: Annual Review of Virology
https://www.readbyqxmd.com/read/27548280/single-molecule-fish-reveals-non-selective-packaging-of-rift-valley-fever-virus-genome-segments
#19
Paul J Wichgers Schreur, Jeroen Kortekaas
The bunyavirus genome comprises a small (S), medium (M), and large (L) RNA segment of negative polarity. Although genome segmentation confers evolutionary advantages by enabling genome reassortment events with related viruses, genome segmentation also complicates genome replication and packaging. Accumulating evidence suggests that genomes of viruses with eight or more genome segments are incorporated into virions by highly selective processes. Remarkably, little is known about the genome packaging process of the tri-segmented bunyaviruses...
August 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27517952/homage-to-richard-m-elliott
#20
EDITORIAL
Alain Kohl, Benjamin Brennan, Friedemann Weber
In the last 25 years, the scientific and public attention paid to bunyaviruses has increased considerably.[...].
2016: Viruses
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