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https://www.readbyqxmd.com/read/28809602/fertility-preservation-and-sexual-health-after-cancer-therapy
#1
Nigel Pereira, Glenn L Schattman
Recent developments in cancer diagnostics and treatments have considerably improved long-term survival rates. Despite improvements in chemotherapy regimens, more focused radiotherapy and diverse surgical options, cancer treatments often have gonadotoxic side-effects that can manifest as loss of fertility or sexual dysfunction, particularly in young cancer survivors. In this review, we focus on two pertinent quality-of-life issues in female cancer survivors of reproductive age-fertility preservation and sexual function...
August 15, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28797029/successful-use-of-equine-anti-thymocyte-globulin-atgam-for-fulminant-myocarditis-secondary-to-nivolumab-therapy
#2
Rebecca Y Tay, Elizabeth Blackley, Catriona McLean, Maggie Moore, Peter Bergin, Sanjeev Gill, Andrew Haydon
BACKGROUND: Immune-mediated myocarditis is an uncommon adverse effect of immune checkpoint inhibition and is associated with a high rate of mortality. METHODS: In this reported case, a 64-year-old woman with right temporo-parietal glioblastoma IDH-WT was treated with nivolumab, temozolomide and radiation therapy on a clinical trial. She developed malignant arrhythmias secondary to histologically confirmed severe immune-mediated myocarditis. She was treated with equine anti-thymocyte globulin (ATGAM) due to development of malignant arrhythmias refractory to high-dose corticosteroids...
August 10, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28780968/efficacy-and-safety-of-rifaximin-associated-with-standard-triple-therapy-omeprazole-clarithromycin-and-amoxicillin-for-h-pylori-eradication-a-phase-iv-pilot-clinical-trial
#3
Mercedes Ramas, Maria G Donday, Adrian G McNicholl, Javier P Gisbert
BACKGROUND: A progressive decrease in Helicobacter pylori eradication rates has been described over the years, driving the need for new antibiotic treatments. AIM: To evaluate the efficacy and safety of the addition of rifaximin (Spiraxin(®)) to standard triple therapy (omeprazole, amoxicillin and clarithromycin) for the eradication of H. pylori. METHODS: Independent prospective clinical trial (EUDRACT no.: 2013-001080-23). Forty consecutive adult patients were included with H...
August 3, 2017: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/28776324/maternal-and-foetal-outcomes-following-natural-vaginal-versus-caesarean-section-c-section-delivery-in-women-with-bleeding-disorders-and-carriers
#4
REVIEW
Laxminarayan Karanth, Sachchithanantham Kanagasabai, Adinegara Bl Abas
BACKGROUND: Bleeding disorders are uncommon but may pose significant bleeding complications during pregnancy, labour and following delivery for both the woman and the foetus. While many bleeding disorders in women tend to improve in pregnancy, thus decreasing the haemorrhagic risk to the mother at the time of delivery, some do not correct or return quite quickly to their pre-pregnancy levels in the postpartum period. Therefore, specific measures to prevent maternal bleeding and foetal complications during childbirth, are required...
August 4, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28776276/women-s-relationship-power-modifies-the-effect-of-a-randomized-conditional-cash-transfer-intervention-for-safer-sex-in-tanzania
#5
Jan E Cooper, Sandra I McCoy, Lia C H Fernald, Damien de Walque, William H Dow
This study tests whether women's relationship power modifies the effect of a conditional cash transfer (CCT) on STI risk. We analyzed 988 women enrolled in the RESPECT study in Tanzania, a yearlong, randomized-controlled trial testing the effectiveness of a CCT to reduce STI incidence. Women were randomized at the individual level to a no-cash control group, a low-cash, or a high-cash study arm. After one year, there was no main effect of study arm on risk of having an STI among women. However, in tests of heterogeneity, the effect of the CCT varied by a woman's relationship power (adjusted RRs of the interaction term for women with higher relationship power: RR 0...
August 3, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28774663/fast-track-vs-delayed-insertion-of-the-levonorgestrel-releasing-intrauterine-system-after-early-medical-abortion-a-randomized-trial
#6
Riina Korjamo, Maarit Mentula, Oskari Heikinheimo
OBJECTIVE: To compare levonorgestrel (LNG) 52-mg intrauterine system (IUS) expulsion rates with fast track (≤ three days) or delayed (2-4weeks) insertion following mifepristone and misoprostol medical abortion. STUDY DESIGN: In this pilot trial we randomized 108 women≤63days gestation to fast-track (n=55) or delayed (n=53) insertion. Follow-up visits occurred at 2-4weeks, three months and one year. We assessed total and partial expulsion at three months and one year, adverse effects and bleeding profiles...
July 31, 2017: Contraception
https://www.readbyqxmd.com/read/28752418/the-effect-of-perinatal-fish-oil-supplementation-on-neurodevelopment-and-growth-of-infants-a-randomized-controlled-trial
#7
Alireza Ostadrahimi, Hanieh Salehi-Pourmehr, Sakineh Mohammad-Alizadeh-Charandabi, Seifollah Heidarabady, Azizeh Farshbaf-Khalili
INTRODUCTION: Long-chain polyunsaturated fatty acids, the most abundant fatty acids in the brain, are essential for the growth and development of the brain and the retina. OBJECTIVE: To evaluate the effect of fish oil supplementation on the development (primary outcome) and growth of 4- and 6-month-old infants. METHODS: In this triple-blind randomized controlled trial, 150 pregnant women aged 18-35 years, who were referred to healthcare centres of Tabriz-Iran, were randomly allocated into two groups...
July 27, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28750676/evaluation-of-a-bespoke-training-to-increase-uptake-by-midwifery-teams-of-nice-guidance-for-membrane-sweeping-to-reduce-induction-of-labour-a-stepped-wedge-cluster-randomised-design
#8
Sara Kenyon, Sophie Dann, Lucy Hope, Paula Clarke, Amanda Hogan, David Jenkinson, Karla Hemming
BACKGROUND: National guidance recommends pregnant women are offered membrane sweeping at term to reduce induction of labour. Local audit suggested this was not being undertaken routinely across two maternity units in the West Midlands, UK between March and November 2012. METHODS: Bespoke training session for midwifery teams (nine community and one antenatal clinic) was developed to address identified barriers to encourage offer of membrane sweeping, together with an information leaflet for women and appointment of a champion within each team...
July 27, 2017: Trials
https://www.readbyqxmd.com/read/28744896/elective-repeat-caesarean-section-versus-induction-of-labour-for-women-with-a-previous-caesarean-birth
#9
REVIEW
Jodie M Dodd, Caroline A Crowther, Rosalie M Grivell, Andrea R Deussen
BACKGROUND: When a woman has had a previous caesarean birth and requires induction of labour for a subsequent pregnancy, two options are available for her care: an elective repeat caesarean and planned induction of labour. Although risks and benefits are associated with both elective repeat caesarean birth and planned induction of labour, current sources of information are limited to non-randomised cohort studies, and studies designed in this way have significant potential for bias. Consequently, any conclusions based on results of these studies are limited in their reliability and should be interpreted with caution...
July 26, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28739616/awakening-with-amantadine-from-a-persistent-vegetative-state-after-subarachnoid-haemorrhage
#10
Sophie Mirabell Lehnerer, Franziska Scheibe, Ralph Buchert, Stefan Kliesch, Andreas Meisel
We report the case of a 36-year-old woman with a subarachnoid haemorrhage (SAH) caused by a rupture of a right-sided middle cerebral artery aneurysm and subsequent malignant infarction of the right hemisphere leading to a persistent vegetative state and severe spastic tetraparesis with recurrent myocloni. Nine months after disease onset, the patient was transferred to our department for diagnostic and therapeutic re-evaluation. The poor clinical condition could not be explained by the brain lesion caused by the SAH or infarction...
July 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28729887/whole-body-vibration-training-improves-balance-control-and-sit-to-stand-performance-among-middle-aged-and-older-adults-a-pilot-randomized-controlled-trial
#11
Ming-Chen Ko, Long-Shan Wu, Sangwoo Lee, Chien-Chun Wang, Po-Fu Lee, Ching-Yu Tseng, Chien-Chang Ho
BACKGROUND: Aging is associated with decreased balance, which increases falling risk. The objective of the current study was to determine the feasibility and effects of whole-body vibration (WBV) training on knee extensor muscle power, limits of stability, and sit-to-stand performance among community-dwelling middle-aged and older adults in the United States. METHODS: A randomized pilot study with participant blinding was conducted. Feasibility outcomes included recruitment and compliance rate...
2017: European Review of Aging and Physical Activity
https://www.readbyqxmd.com/read/28728552/study-protocol-for-a-comparative-effectiveness-trial-of-two-models-of-perinatal-integrated-psychosocial-assessment-the-pipa-project
#12
Nicole Reilly, Emma Black, Georgina M Chambers, Virginia Schmied, Stephen Matthey, Josephine Farrell, Dawn Kingston, Andrew Bisits, Marie-Paule Austin
BACKGROUND: Studies examining psychosocial and depression assessment programs in maternity settings have not adequately considered the context in which psychosocial assessment occurs or how broader components of integrated care, including clinician decision-making aids, may optimise program delivery and its cost-effectiveness. There is also limited evidence relating to the diagnostic accuracy of symptom-based screening measures used in this context. The Perinatal Integrated Psychosocial Assessment (PIPA) Project was developed to address these knowledge gaps...
July 20, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28725344/complete-response-of-mediastinal-clear-cell-sarcoma-to-pembrolizumab-with-radiotherapy
#13
Samuel Marcrom, Jennifer F De Los Santos, Robert M Conry
BACKGROUND: Clear cell sarcoma (CCS) is a rare, aggressive soft tissue sarcoma thought to derive from neural crest and characterized by a 12;22 translocation. The resulting fusion protein directly activates expression of the melanocyte master transcription factor and drives the same down-stream pathways in CCS and melanoma leading to significant clinical parallels between these malignancies. Striking success of immune checkpoint blockade in melanoma has promoted interest in immunotherapy of CCS...
2017: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/28720130/psychosocial-and-behavioral-impact-of-breast-cancer-risk-assessed-by-testing-for-common-risk-variants-protocol-of-a-prospective-study
#14
Tatiane Yanes, Bettina Meiser, Mary-Anne Young, Rajneesh Kaur, Gillian Mitchell, Kristine Barlow-Stewart, Tony Roscioli, Jane Halliday, Paul James
BACKGROUND: The 'common variant, common disease' model predicts that a significant component of hereditary breast cancer unexplained by pathogenic variants in moderate or high-penetrance genes is due to the cumulative effect of common risk variants in DNA (polygenic risk). Assessing a woman's breast cancer risk by testing for common risk variants can provide useful information for women who would otherwise receive uninformative results by traditional monogenic testing. Despite increasing support for the utility of common risk variants in hereditary breast cancer, research findings have not yet been integrated into clinical practice...
July 18, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28719791/effectiveness-of-psychosocial-and-educational-prenatal-and-postnatal-care-interventions-for-married-immigrant-women-in-korea-systematic-review-and-meta-analysis
#15
Sun Kyung Kim, Seyeon Park, Sukhee Ahn
The rapid influx of married immigrant women from low-income Asian countries is a concern in South Korea, Japan, and Taiwan. In South Korea, 1 in 10 couples includes a Korean man and a migrant woman, increasing the need for prenatal and postnatal care interventions. Studies published in English or Korean after 2000 were retrieved from 8 databases and reviewed via a systematic review and meta-analysis of the effectiveness of prenatal and postnatal psychosocial and educational interventions in Korea. Of 3583 records, 10 studies (1 randomized controlled trial [RCT] and 9 non-RCTs) involving 408 married immigrant women fulfilled the inclusion criteria...
July 2017: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/28714712/spatial-cues-influence-the-visual-perception-of-gender
#16
Sarah Ariel Lamer, Max Weisbuch, Timothy D Sweeny
Spatial localization is a basic process in vision, occurring reliably when people encounter an object or person. Yet the role of spatial-location in the visual perception of people is poorly understood. We explored the extent to which spatial-location distorts the perception of gender. Consistent with evidence that the perception of objects is constrained by their location in visual scenes, enhancing perception for objects in their typical location (e.g., Biederman et al., 1982), we hypothesized that people would see relatively greater femininity in faces that appeared lower in space...
July 17, 2017: Journal of Experimental Psychology. General
https://www.readbyqxmd.com/read/28701023/preterm-preeclampsia-and-timing-of-delivery-a-systematic-literature-review
#17
José Paulo de Siqueira Guida, Fernanda Garanhani Surita, Mary Angela Parpinelli, Maria Laura Costa
Introduction Preeclampsia, a multifactorial disease with pathophysiology not yet fully understood, is a major cause of maternal and perinatal morbidity and mortality, especially when preterm. The diagnosis is performed when there is an association between arterial hypertension and proteinuria or evidence of severity. There are unanswered questions in the literature considering the timing of delivery once preterm preeclampsia has been diagnosed, given the risk of developing maternal complications versus the risk of adverse perinatal outcomes associated with prematurity...
July 12, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28700587/community-and-health-system-intervention-to-reduce-disrespect-and-abuse-during-childbirth-in-tanga-region-tanzania-a-comparative-before-and-after-study
#18
Stephanie A Kujawski, Lynn P Freedman, Kate Ramsey, Godfrey Mbaruku, Selemani Mbuyita, Wema Moyo, Margaret E Kruk
BACKGROUND: Abusive treatment of women during childbirth has been documented in low-resource countries and is a deterrent to facility utilization for delivery. Evidence for interventions to address women's poor experience is scant. We assessed a participatory community and health system intervention to reduce the prevalence of disrespect and abuse during childbirth in Tanzania. METHODS AND FINDINGS: We used a comparative before-and-after evaluation design to test the combined intervention to reduce disrespect and abuse...
July 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28691442/acceptability-of-woman-delivered-hiv-self-testing-to-the-male-partner-and-additional-interventions-a-qualitative-study-of-antenatal-care-participants-in-malawi
#19
Augustine Talumba Choko, Moses Kelly Kumwenda, Cheryl Case Johnson, Doreen Wongera Sakala, Maria Chifuniro Chikalipo, Katherine Fielding, Jeremiah Chikovore, Nicola Desmond, Elizabeth Lucy Corbett
INTRODUCTION: In the era of ambitious HIV targets, novel HIV testing models are required for hard-to-reach groups such as men, who remain underserved by existing services. Pregnancy presents a unique opportunity for partners to test for HIV, as many pregnant women will attend antenatal care (ANC). We describe the views of pregnant women and their male partners on HIV self-test kits that are woman-delivered, alone or with an additional intervention. METHODS: A formative qualitative study to inform the design of a multi-arm multi-stage cluster-randomized trial, comprised of six focus group discussions and 20 in-depth interviews, was conducted...
June 26, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28690586/modulations-in-the-peripheral-immune-system-of-glioblastoma-patient-is-connected-to-therapy-and-tumor-progression-a-case-report-from-the-immo-glio-01-trial
#20
Paul F Rühle, Nicole Goerig, Roland Wunderlich, Rainer Fietkau, Udo S Gaipl, Annedore Strnad, Benjamin Frey
Immune responses are important for efficient tumor elimination, also in immune privileged organs such as the brain. Fostering antitumor immunity has therefore become an important challenge in cancer therapy. This cannot only be achieved by immunotherapies as already standard treatments such as radiotherapy and chemotherapy modify the immune system. Consequently, the understanding of how the tumor, the tumor microenvironment, and immune system are modulated by cancer therapy is required for prognosis, prediction, and therapy adaption...
2017: Frontiers in Neurology
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