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https://www.readbyqxmd.com/read/28927736/should-we-add-tranexamic-acid-to-postpartum-haemorrhage-protocols-after-the-woman-trial-publication
#1
EDITORIAL
Anne-Sophie Ducloy-Bouthors, Anne Godier
No abstract text is available yet for this article.
September 16, 2017: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/28927395/detection-and-risk-stratification-of-women-at-high-risk-of-preterm-birth-in-rural-communities-near-nagpur-india
#2
Archana Patel, Amber Abhijeet Prakash, Yamini V Pusdekar, Hemant Kulkarni, Patricia Hibberd
BACKGROUND: Presently, preterm birth is globally the leading cause of neonatal mortality. Prompt community based identification of women at high risk for preterm births (HRPB) can either help to avert preterm births or avail effective interventions to reduce neonatal mortality due to preterm births. We evaluated the performance of a package to train community workers to detect the presence of signs or symptoms of HRPB. METHODS: Pregnant women enrolled in the intervention arm of a cluster randomized trial of Antenatal Corticosteroids (ACT Trial) conducted at Nagpur, India were informed about 4 directly observable signs and symptoms of preterm labor...
September 19, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28926357/first-in-human-treatment-with-a-dendritic-cell-targeting-lentiviral-vector-expressing-ny-eso-1-lv305-induces-deep-durable-response-in-refractory-metastatic-synovial-sarcoma-patient
#3
Seth M Pollack, Hailing Lu, Sacha Gnjatic, Neeta Somaiah, Ryan B O'Malley, Robin L Jones, Frank J Hsu, Jan Ter Meulen
Effective induction of antitumor T cells is a pivotal goal of cancer immunotherapy. To this end, lentiviral vectors (LV) are uniquely poised to directly prime CD8 T-cell responses via transduction of dendritic cells in vivo and have shown promise as active cancer therapeutics in preclinical tumor models. However, until now, significant barriers related to production and regulation have prevented their widespread use in the clinic. We developed LV305, a dendritic cell-targeting, integration-deficient, replication incompetent LV from the ZVex platform, encoding the full-length cancer-testis antigen NY-ESO-1...
September 18, 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/28923034/an-implementation-science-protocol-of-the-women-s-health-coop-in-healthcare-settings-in-cape-town-south-africa-a-stepped-wedge-design
#4
Wendee M Wechsberg, Jacqueline W Ndirangu, Ilene S Speizer, William A Zule, Winnifred Gumula, Courtney Peasant, Felicia A Browne, Laura Dunlap
BACKGROUND: HIV persists as a public health emergency in South Africa, especially among women of childbearing age. In response to the HIV epidemic, the Joint United Nations Programme on HIV/AIDS has put forth the 90-90-90 global goals to achieve an AIDS-free generation by 2020. This goal aspires to have 90% of people living with HIV diagnosed; 90% of those who test positive on sustained antiretroviral therapy (ART); and 90% of those on ART be virally suppressed. Ensuring access to ART is an important first step in reducing HIV incidence, especially among vulnerable populations such as women who use substances and bear the burden of HIV in South Africa...
September 18, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28918404/combined-caesarean-with-splenectomy-in-pregnancy-with-portal-hypertension-defining-plausibility
#5
Manjunath Maruti Pol, Latika Uniyal Chawla, Yashwant Singh Rathore, Ritesh Goel
24-year-old woman at 28 weeks gestation was referred from peripheral hospital with diagnosis of pregnancy with portal hypertension. She had received multiple transfusion for pancytopaenia in the past and had undergone endoscopic sclerotherapy for oesophageal varices. Initially, she was admitted in our hospital at 28 weeks gestation for blood transfusion and was evaluated by multispecialty team of doctors. She was advised splenectomy for transfusion-dependent pancytopaenia secondary to hypersplenism in non-cirrhotic portal hypertension...
September 15, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28913590/challenges-of-anticoagulation-therapy-in-pregnancy
#6
REVIEW
Annemarie E Fogerty
Thrombotic complications in pregnancy represent a major cause of morbidity and mortality. Pregnancy is a primary hypercoagulable state due to enhanced production of clotting factors, a decrease in protein S activity, and inhibition of fibrinolysis. These physiologic changes will yield a collective rate of venous thromboembolism (VTE) of about 1-2 in 1000 pregnancies for the general obstetric population, which represents a five- to tenfold increased risk in pregnancy compared to age-matched non-pregnant peers...
September 14, 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28913142/day-3-embryo-transfer-versus-day-5-blastocyst-transfers-a-prospective-randomized-controlled-trial
#7
Şafak Hatırnaz, Mine Kanat Pektaş
OBJECTIVE: This study aimed to show whether transferring day 5 embryos resulted in higher implantation and pregnancy rates than transferring day 3 embryos in Turkish women undergoing an intracytoplasmic sperm injection (ICSI) cycle. MATERIALS AND METHODS: A total of 190 women who had ICSI after retrieval of more than four oocytes on the day of fertilization check were randomly assigned to undergo embryo transfer either on day 3 or day 5. RESULTS: Day 3 and day 5 transfers were statistically similar with respect to the age of woman (p=0...
June 2017: Turk J Obstet Gynecol
https://www.readbyqxmd.com/read/28911749/effect-of-participatory-women-s-groups-and-counselling-through-home-visits-on-children-s-linear-growth-in-rural-eastern-india-caring-trial-a-cluster-randomised-controlled-trial
#8
Nirmala Nair, Prasanta Tripathy, H S Sachdev, Hemanta Pradhan, Sanghita Bhattacharyya, Rajkumar Gope, Sumitra Gagrai, Shibanand Rath, Suchitra Rath, Rajesh Sinha, Swati Sarbani Roy, Suhas Shewale, Vijay Singh, Aradhana Srivastava, Anthony Costello, Andrew Copas, Jolene Skordis-Worrall, Hassan Haghparast-Bidgoli, Naomi Saville, Audrey Prost
BACKGROUND: Around 30% of the world's stunted children live in India. The Government of India has proposed a new cadre of community-based workers to improve nutrition in 200 districts. We aimed to find out the effect of such a worker carrying out home visits and participatory group meetings on children's linear growth. METHODS: We did a cluster-randomised controlled trial in two adjoining districts of Jharkhand and Odisha, India. 120 clusters (around 1000 people each) were randomly allocated to intervention or control using a lottery...
October 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28891906/first-in-human-treatment-with-a-dendritic-cell-targeting-lentiviral-vector-expressing-ny-eso-1-lv305-induces-deep-durable-response-in-refractory-metastatic-synovial-sarcoma-patient
#9
Seth M Pollack, Hailing Lu, Sacha Gnjatic, Neeta Somaiah, Ryan B O'Malley, Robin L Jones, Frank J Hsu, Jan Ter Meulen
Effective induction of antitumor T cells is a pivotal goal of cancer immunotherapy. To this end, lentiviral vectors (LV) are uniquely poised to directly prime CD8 T-cell responses via transduction of dendritic cells in vivo and have shown promise as active cancer therapeutics in preclinical tumor models. However, until now, significant barriers related to production and regulation have prevented their widespread use in the clinic. We developed LV305, a dendritic cell-targeting, integration-deficient, replication incompetent LV from the ZVex platform, encoding the full-length cancer-testis antigen NY-ESO-1...
October 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/28886475/accuracy-of-screening-women-at-familial-risk-of-breast-cancer-without-a-known-gene-mutation-individual-patient-data-meta-analysis
#10
REVIEW
Xuan-Anh Phi, Nehmat Houssami, Maartje J Hooning, Christopher C Riedl, Martin O Leach, Francesco Sardanelli, Ellen Warner, Isabelle Trop, Sepideh Saadatmand, Madeleine M A Tilanus-Linthorst, Thomas H Helbich, Edwin R van den Heuvel, Harry J de Koning, Inge-Marie Obdeijn, Geertruida H de Bock
INTRODUCTION: Women with a strong family history of breast cancer (BC) and without a known gene mutation have an increased risk of developing BC. We aimed to investigate the accuracy of screening using annual mammography with or without magnetic resonance imaging (MRI) for these women outside the general population screening program. METHODS: An individual patient data (IPD) meta-analysis was conducted using IPD from six prospective screening trials that had included women at increased risk for BC: only women with a strong familial risk for BC and without a known gene mutation were included in this analysis...
September 5, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28881415/uterine-massage-as-part-of-active-management-of-the-third-stage-of-labor-for-preventing-postpartum-hemorrhage-during-vaginal-delivery-a-systematic-review-and-meta-analysis-of-randomized-trials
#11
Gabriele Saccone, Claudia Caissutti, Andrea Ciardulli, Hany Abdel-Aleem, Justus Hofmeyr, Vincenzo Berghella
The first cause of maternal death worldwide is postpartum hemorrhage (PPH), responsible for an estimated 127,000 deaths annually. Failure of the uterus to contract adequately after childbirth is the most common cause of PPH. In the absence of timely and appropriate action, a woman could die within a few hours. This article is protected by copyright. All rights reserved.
September 7, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28879208/tumor-necrosis-factor-alpha-inhibitor-induced-acute-pancreatitis
#12
Monia E Werlang, Michele D Lewis, Michael J Bartel
Treatment of acute pancreatitis remains a challenge, with therapy focused on supportive care and treating the inciting etiology. Tumor necrosis factor-alpha (TNFα) inhibitors have shown promising results treating acute pancreatitis in animal models, but they have not been evaluated in human trials yet. A 25-year-old woman presented with ulcerative colitis. She was unresponsive to immunomodulators and developed acute pancreatitis shortly after initiation of a TNFα inhibitor. Her symptoms subsided after discontinuation of the medication, but reemerged when a different TNFα inhibitor was introduced to control her ulcerative colitis...
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28872489/a-case-of-pure-red-cell-aplasia-during-nivolumab-therapy-for-cardiac-metastatic-melanoma
#13
Akihiko Yuki, Tatsuya Takenouchi, Sumiko Takatsuka, Takuro Ishiguro
Nivolumab is an antibody against programmed cell death 1 and functions as an immune checkpoint inhibitor for various malignancies, including unresectable melanomas. Nivolumab causes several immune-related adverse events, which typically include skin rash, pneumonitis, thyroid dysfunction, hepatitis, and colitis; in rare cases, anemia may be present. There are several reports of autoimmune hemolytic anemia that has developed in response to nivolumab; however, there are few reports of pure red cell aplasia (PRCA)...
September 1, 2017: Melanoma Research
https://www.readbyqxmd.com/read/28868193/cervical-cancer-metastasis-to-the-brain-a-case-report-and-review-of-literature
#14
REVIEW
Kaleigh Fetcko, Dibson D Gondim, Jose M Bonnin, Mahua Dey
BACKGROUND: Intracranial metastasis from cervical cancer is a rare occurrence. METHODS: In this study we describe a case of cervical cancer metastasis to the brain and perform an extensive review of literature from 1956 to 2016, to characterize clearly the clinical presentation, treatment options, molecular markers, targeted therapies, and survival of patients with this condition. RESULTS: An elderly woman with history of cervical cancer in remission, presented 2 years later with a right temporo-parietal tumor, which was treated with surgery and subsequent stereotactic radiosurgery (SRS) to the resection cavity...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28854728/a-second-dose-of-kisspeptin-54-improves-oocyte-maturation-in-women-at-high-risk-of-ovarian-hyperstimulation-syndrome-a-phase-2-randomized-controlled-trial
#15
Ali Abbara, Sophie Clarke, Rumana Islam, Julia K Prague, Alexander N Comninos, Shakunthala Narayanaswamy, Deborah Papadopoulou, Rachel Roberts, Chioma Izzi-Engbeaya, Risheka Ratnasabapathy, Alexander Nesbitt, Sunitha Vimalesvaran, Rehan Salim, Stuart A Lavery, Stephen R Bloom, Les Huson, Geoffrey H Trew, Waljit S Dhillo
STUDY QUESTION: Can increasing the duration of LH-exposure with a second dose of kisspeptin-54 improve oocyte maturation in women at high risk of ovarian hyperstimulation syndrome (OHSS)? SUMMARY ANSWER: A second dose of kisspeptin-54 at 10 h following the first improves oocyte yield in women at high risk of OHSS. WHAT IS KNOWN ALREADY: Kisspeptin acts at the hypothalamus to stimulate the release of an endogenous pool of GnRH from the hypothalamus...
September 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28845463/contraceptive-vaginal-ring-experiences-among-women-and-men-in-kisumu-kenya-a-qualitative-study
#16
E McLellan-Lemal, K Ondeng'e, D A Gust, M Desai, F O Otieno, P A Madiega, B Nyagol, E M Makanga
BACKGROUND: Future HIV prevention options for women will likely include Antiretroviral (ARV)-based intravaginal rings. Valuable insights may be gained by examining user experiences with a similar licensed technology, a contraceptive ring, especially in settings where this technology may not be currently available. METHODS: In-depth interviews with 24 females enrolled in a trial assessing acceptability and use of a contraceptive ring, and 20 male sexual partners were conducted September 2014-April 2015...
March 2017: Frontiers in Women's Health
https://www.readbyqxmd.com/read/28841772/prop-nontaster-women-lose-more-weight-following-a-low-carbohydrate-versus-a-low-fat-diet-in-a-randomized-controlled-trial
#17
Brenda Burgess, Hollie A Raynor, Beverly J Tepper
OBJECTIVE: Taste blindness to 6-n-propylthiouracil (PROP) associates with increased fat preference and intake. No studies have matched a diet to a woman's PROP phenotype to improve weight loss. This study investigated (1) whether PROP nontaster (NT) women would lose more weight following a low-carbohydrate (LC) diet than a low-fat (LF) diet, and (2) whether PROP supertaster (ST) women would lose more weight following a LF diet than a LC diet. METHODS: One hundred seven women (BMI = 34...
August 25, 2017: Obesity
https://www.readbyqxmd.com/read/28838804/castor-oil-as-a-natural-alternative-to-labor-induction-a-retrospective-descriptive-study
#18
Andrea L DeMaria, Beth Sundstrom, Grace E Moxley, Kendall Banks, Ashlan Bishop, Lesley Rathbun
AIM: To describe birthing outcomes among women who consumed castor oil cocktail as part of a freestanding birth center labor induction protocol. METHODS: De-identified data from birth logs and electronic medical records were entered into SPSS Statistics 22.0 for analysis for all women who received the castor oil cocktail (n=323) to induce labor between January 2008 and May 2015 at a birth center in the United States. Descriptive statistics were analyzed for trends in safety and birthing outcomes...
August 21, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/28838458/successful-simultaneous-pancreas-kidney-re-transplantation-in-a-highly-human-leukocyte-antigen-sensitized-patient
#19
S Kykalos, A Wunsch, T Klein, R Viebahn, P Schenker
BACKGROUND: The waiting time for re-transplantation for sensitized patients is greatly prolonged, given the lack of transplants that are available for this group and additional immunologic barriers. We report the case of a successful re-transplantation in a patient with very high levels of panel reactive antibodies ([PRA] >85%). METHODS: A 45-year-old woman had repetitive rejections after simultaneous pancreas-kidney transplantation, with consequent loss of function of both transplanted organs...
September 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28834955/higher-transplacental-pathogen-specific-antibody-transfer-among-pregnant-women-randomized-to-triple-antiretroviral-treatment-versus-short-course-zidovudine
#20
Rose Bosire, Carey Farquhar, Ruth Nduati, Kristina Broliden, Stanley Luchters, Philippe Van de Perre, Isabelle De Vincenzi, Michele Merkel, Veronicah Wachuka, Dorothy Mbori-Ngacha, Grace John-Stewart, Barbara Lohman-Payne, Marie Reilly
BACKGROUND: HIV-1 infection may impair transplacental antibody transfer to infants. The impact of highly active antiretroviral treatment (ART) given during pregnancy on transplacental antibody transport is unknown. METHODS: HIV-1 infected pregnant women with CD4 counts between 200 - 500 were randomized to short-course zidovudine (ZDV) or triple ART at 32 weeks gestation for prevention of mother-to-child HIV-1 transmission. Levels of maternal antibody against measles, pneumococcus and rotavirus at delivery, and antibody transfer to the baby through cord blood, were compared between trial arms...
August 19, 2017: Pediatric Infectious Disease Journal
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