Roman Tikhomirov, Robert H Oakley, Cali Anderson, Yirong Xiang, Sami Al Othman, Matthew Smith, Sana Yaar, Eleonora Torre, Jianying Li, Leslie R Wilson, David R Goulding, Ian Donaldson, Erika Harno, Luca Soattin, Holly A Shiels, Gwilym M Morris, Henggui Zhang, Mark R Boyett, John A Cidlowski, Pietro Mesirca, Matteo E Mangoni, Alicia D'Souza
RATIONALE: Ventricular arrhythmias (VAs) demonstrate a prominent day-night rhythm, commonly presenting in the early morning. Transcriptional rhythms in cardiac ion channels accompany this phenomenon, but their role in the morning vulnerability to VAs and the underlying mechanisms are not understood. OBJECTIVE: The objectives are to investigate the recruitment of transcription factors to time-of-day differentially accessible chromatin that underpins day-night ion channel rhythms and to assess the significance of this for the heart's day-night rhythm in VA susceptibility...
March 27, 2024: Circulation Research