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https://www.readbyqxmd.com/read/28971318/preferences-for-multigene-panel-testing-for-hereditary-breast-cancer-risk-among-ethnically-diverse-brca-uninformative-families
#1
Belinda Vicuña, Harold D Delaney, Kristina G Flores, Lori Ballinger, Melanie Royce, Zoneddy Dayao, Tuya Pal, Anita Y Kinney
Until recently, genetic testing for hereditary breast cancer has primarily focused on pathogenic variants in the BRCA1 and BRCA2 (BRCA) genes. However, advances in DNA sequencing technologies have made simultaneous testing for multiple genes possible. We examined correlates of interest in multigene panel testing and risk communication preferences in an ethnically diverse sample of women who tested negative for BRCA mutations previously but remain at high risk based on their family history (referred to as "BRCA-uninformative") and their at-risk female family members...
October 2, 2017: Journal of Community Genetics
https://www.readbyqxmd.com/read/28970586/microscale-bioreactors-for-in-situ-characterization-of-gi-epithelial-cell-physiology
#2
Cait M Costello, Mikkel B Phillipsen, Leonard M Hartmanis, Marek A Kwasnica, Victor Chen, David Hackam, Matthew W Chang, William E Bentley, John C March
The development of in vitro artificial small intestines that realistically mimic in vivo systems will enable vast improvement of our understanding of the human gut and its impact on human health. Synthetic in vitro models can control specific parameters, including (but not limited to) cell types, fluid flow, nutrient profiles and gaseous exchange. They are also "open" systems, enabling access to chemical and physiological information. In this work, we demonstrate the importance of gut surface topography and fluid flow dynamics which are shown to impact epithelial cell growth, proliferation and intestinal cell function...
October 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28967945/nanoscale-patterning-of-self-assembled-monolayer-sam-functionalised-substrates-with-single-molecule-contact-printing
#3
M Sajfutdinow, K Uhlig, A Prager, C Schneider, B Abel, D M Smith
Defined arrangements of individual molecules are covalenty connected ("printed") onto SAM-functionalised gold substrates with nanometer resolution. Substrates were initially pre-functionlised by coating with 3,3'-dithiodipropionic acid (DTPA) to form a self-assembled monolayer (SAM), which was characterised by atomic force microscopy (AFM), contact angle goniometry, cyclic voltammetry and surface plasmon resonance (SPR) spectroscopy. Pre-defined "ink" patterns displayed on DNA origami-based single-use carriers ("stamp") were covalently conjugated to the SAM using 1-ethyl-3-(3-dimethylamino-propyl)carbodiimide (EDC) and N-hydroxy-succinimide (NHS)...
October 12, 2017: Nanoscale
https://www.readbyqxmd.com/read/28964552/3d-printed-tracheoesophageal-puncture-and-prosthesis-placement-simulator
#4
Samuel R Barber, Elliott D Kozin, Matthew R Naunheim, Rosh Sethi, Aaron K Remenschneider, Daniel G Deschler
OBJECTIVES: A tracheoesophageal prosthesis (TEP) allows for speech after total laryngectomy. However, TEP placement is technically challenging, requiring a coordinated series of steps. Surgical simulators improve technical skills and reduce operative time. We hypothesize that a reusable 3-dimensional (3D)-printed TEP simulator will facilitate comprehension and rehearsal prior to actual procedures. METHODS: The simulator was designed using Fusion360 (Autodesk, San Rafael, CA)...
August 18, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28962741/effect-of-print-layer-height-and-printer-type-on-the-accuracy-of-3-dimensional-printed-orthodontic-models
#5
Christian S Favero, Jeryl D English, Benjamin E Cozad, John O Wirthlin, Megan M Short, F Kurtis Kasper
INTRODUCTION: Three-dimensional (3D) printing technologies enable production of orthodontic models from digital files; yet a range of variables associated with the process could impact the accuracy and clinical utility of the models. The objective of this study was to investigate the effect of print layer height on the accuracy of orthodontic models printed 3 dimensionally using a stereolithography format printer and to compare the accuracy of orthodontic models fabricated with several commercially available 3D printers...
October 2017: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/28952512/ereptiospiration
#6
Christine Woolley, Antonio A Garcia, Marco Santello
Pure coconut oil, lanolin, and acetaminophen were vaporized at rates of 1-50 mg/min, using a porous network exhibiting a temperature gradient from 5000 to 5500 K/mm, without incurring noticeable chemical changes due to combustion, oxidation, or other thermally-induced chemical structural changes. The newly coined term "ereptiospiration" is used here to describe this combination of thermal transpiration at high temperature gradients since the process can force the creation of thermal aerosols by rapid heating in a localized zone...
April 12, 2017: Bioengineering
https://www.readbyqxmd.com/read/28948399/interventional-magnetic-resonance-imaging-guided-carotid-embolectomy-using-a-novel-resonant-marker-catheter-demonstration-of-preclinical-feasibility
#7
Jeffrey K Yang, Andre M Cote, Caroline D Jordan, Sravani Kondapavulur, Aaron D Losey, David McCoy, Andrew Chu, Jay F Yu, Teri Moore, Carol Stillson, Fabio Settecase, Matthew D Alexander, Andrew Nicholson, Daniel L Cooke, Maythem Saeed, Dave Barry, Alastair J Martin, Mark W Wilson, Steven W Hetts
To assess the visualization and efficacy of a wireless resonant circuit (wRC) catheter system for carotid artery occlusion and embolectomy under real-time MRI guidance in vivo, and to compare MR imaging modality with x-ray for analysis of qualitative physiological measures of blood flow at baseline and after embolectomy. The wRC catheter system was constructed using a MR compatible PEEK fiber braided catheter (Penumbra, Inc, Alameda, CA) with a single insulated longitudinal copper loop soldered to a printed circuit board embedded within the catheter wall...
September 25, 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28934247/the-extent-of-intrauterine-growth-restriction-determines-the-severity-of-cerebral-injury-and-neurobehavioural-deficits-in-rodents
#8
Crystal A Ruff, Stuart D Faulkner, Prakasham Rumajogee, Stephanie Beldick, Warren Foltz, Jennifer Corrigan, Alfred Basilious, Shangjun Jiang, Shanojan Thiyagalingam, Jerome Y Yager, Michael G Fehlings
BACKGROUND: Cerebral Palsy (CP) is the most common physical pediatric neurodevelopmental disorder and spastic diplegic injury is its most frequent subtype. CP results in substantial neuromotor and cognitive impairments that have significant socioeconomic impact. Despite this, its underlying pathophysiological mechanisms and etiology remain incompletely understood. Furthermore, there is a need for clinically relevant injury models, which a) reflect the heterogeneity of the condition and b) can be used to evaluate new translational therapies...
2017: PloS One
https://www.readbyqxmd.com/read/28933756/a-disposable-amperometric-sensor-based-on-high-performance-pedot-pss-ionic-liquid-nanocomposite-thin-film-modified-screen-printed-electrode-for-the-analysis-of-catechol-in-natural-water-samples
#9
Francis D Krampa, Yaw Aniweh, Gordon A Awandare, Prosper Kanyong
A conducting polymer-based composite material of poly(3,4-ethylenedioxythiophene) (PEDOT): poly(4-styrenesulfonate) (PSS) doped with different percentages of a room temperature ionic liquid (IL), 1-ethyl-3-methylimidazolium tetrafluoroborate ([EMIM][BF₄]), was prepared and a very small amount of the composite (2.0 µL) was drop-coated on the working area of a screen-printed carbon electrode (SPCE). The SPCE, modified with PEDOT:PSS/IL composite thin-film, was characterized by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), scanning electron microscopy (SEM), profilometry and sessile contact angle measurements...
July 26, 2017: Sensors
https://www.readbyqxmd.com/read/28901195/feedforward-coordinate-control-of-a-robotic-cell-injection-catheter
#10
Weyland Cheng, Peter K Law
Remote and robotically actuated catheters are the stepping-stones toward autonomous catheters, where complex intravascular procedures may be performed with minimal intervention from a physician. This article proposes a concept for the positional, feedforward control of a robotically actuated cell injection catheter used for the injection of myogenic or undifferentiated stem cells into the myocardial infarct boundary zones of the left ventricle. The prototype for the catheter system was built upon a needle-based catheter with a single degree of deflection, a 3-D printed handle combined with actuators, and the Arduino microcontroller platform...
August 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28901052/noninvasive-three-dimensional-full-field-body-sensor-for-surface-deformation-monitoring-of-human-body-in-vivo
#11
Zhenning Chen, Xinxing Shao, Xiaoyuan He, Jialin Wu, Xiangyang Xu, Jinlin Zhang
Noninvasive, three-dimensional (3-D), full-field surface deformation measurements of the human body are important for biomedical investigations. We proposed a 3-D noninvasive, full-field body sensor based on stereo digital image correlation (stereo-DIC) for surface deformation monitoring of the human body in vivo. First, by applying an improved water-transfer printing (WTP) technique to transfer optimized speckle patterns onto the skin, the body sensor was conveniently and harmlessly fabricated directly onto the human body...
September 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28895659/implementation-strategies-for-health-systems-in-low-income-countries-an-overview-of-systematic-reviews
#12
REVIEW
Tomas Pantoja, Newton Opiyo, Simon Lewin, Elizabeth Paulsen, Agustín Ciapponi, Charles S Wiysonge, Cristian A Herrera, Gabriel Rada, Blanca Peñaloza, Lilian Dudley, Marie-Pierre Gagnon, Sebastian Garcia Marti, Andrew D Oxman
BACKGROUND: A key function of health systems is implementing interventions to improve health, but coverage of essential health interventions remains low in low-income countries. Implementing interventions can be challenging, particularly if it entails complex changes in clinical routines; in collaborative patterns among different healthcare providers and disciplines; in the behaviour of providers, patients or other stakeholders; or in the organisation of care. Decision-makers may use a range of strategies to implement health interventions, and these choices should be based on evidence of the strategies' effectiveness...
September 12, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28853281/regulating-molecular-aggregations-of-polymers-via-ternary-copolymerization-strategy-for-efficient-solar-cells
#13
Qian Wang, Yingying Wang, Wei Zheng, Bilal Shahid, Meng Qiu, Di Wang, Dangqiang Zhu, Renqiang Yang
For many high-performance photovoltaic materials in polymer solar cells (PSCs), the active layers usually need to be spin-coated at high temperature due to the strong intermolecular aggregation of donor polymers, which is unfavorable in device repeatability and large-scale PSC printing. In this work, we adopted a ternary copolymerization strategy to regulate polymer solubility and molecular aggregation. A series of D-A1-D-A2 random polymers based on different acceptors, strong electron-withdrawing unit ester substituted thieno[3,4-b]thiophene (TT-E), and highly planar dithiazole linked TT-E (DTzTT) were constructed to realize the regulation of molecular aggregation and simplification of device fabrication...
September 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28844415/novel-curved-surface-preparation-technique-for-knee-resurfacing
#14
Jianmo Li, Susannah Clarke, Justin P Cobb, Andrew A Amis
Conventional tools are incapable of preparing the curved articular surface geometry required during cartilage repair procedures. A novel curved surface preparation technique was proposed and tested to provide an accurate low-cost solution. Three shapes of samples, with flat, 30 mm radius and 60 mm radius surfaces, were manufactured from foam bone substitute for testing. Registering guides and cutting guides were designed and 3-D printed to fit onto the foam samples. A rotational cutting tool with an adapter was used to prepare the surfaces following the guidance slots in the cutting guides...
August 22, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28837196/inkjet-fabrication-of-highly-efficient-luminescent-eu-doped-zro2-nanostructures
#15
Alexandra D Furasova, Vladimir Ivanovski, Alexandr V Yakovlev, Valentine A Milichko, Vladimir V Vinogradov, Alexandr V Vinogradov
We have demonstrated for the first time an inkjet fabrication of highly efficient luminescent structures based on Eu-doped ZrO2 nanocrystals (3.4 ± 0.3 nm), with a refractive index close to the one of the bulk materials. The nanoparticles were synthesised using a nonhydrolytic method in benzyl alcohol where the particles were post treated using acetic acid, leading to the formation of a stable colloid. It was shown that the non-polar methyl group of the acetic acid is responsible for its penetration through the hydrophobic layer all the way through to the surface of the ZrO2, leading to the cleavage of the Zr-OCH2C6H5 bond and the formation of surface acetate species and a concomitant decomposition of the zirconia superlattice...
September 14, 2017: Nanoscale
https://www.readbyqxmd.com/read/28828951/clinical-outcomes-of-patient-specific-porous-titanium-endoprostheses-in-dogs-with-tumors-of-the-mandible-radius-or-tibia-12-cases-2013-2016
#16
Jonathan P Bray, Andrew Kersley, Warwick Downing, Katherine R Crosse, Andrew J Worth, Arthur K House, Guy Yates, Alastair R Coomer, Ian W M Brown
OBJECTIVE To characterize the processes involved in and outcomes achieved with custom-designed patient-specific implants to provide functional replacement of skeletal structures in dogs with tumors of the mandible, radius, or tibia. DESIGN Prospective case series. ANIMALS 6 dogs with mandibular tumors, 5 with tumors of the distal aspect of the radius, and 1 with a tumor in the distal aspect of the tibia treated from June 2013 to September 2016 at 3 referral centers. PROCEDURES After tumor staging, implants were designed from patients' CT scans by means of various computer-aided design applications and printed by means of selective laser melting in titanium-6 aluminum-4 vanadium alloy...
September 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28800425/implementing-the-adapted-physical-education-e-learning-program-into-physical-education-teacher-education-program
#17
Eun Hye Kwon, Martin E Block
According to the Ministry of Education Korea (2014), the approximately 70.4% of all students with disabilities are included in general schools in Korea. However, studies show that Korean GPE teachers do not feel comforatble or prepared to include students with disabilities (Oh & Lee, 1999; Roh, 2002; Roh & Oh, 2005). The purpose of this study was to explore whether an APE e-learning supplement would have an impact on the level of self-efficacy and content knowledge of pre-service teachers related to including students with intellectual disabilities...
August 8, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28795641/fixation-of-hydrogel-constructs-for-cartilage-repair-in-the-equine-model-a-challenging-issue
#18
Irina A D Mancini, Rafael Angel Vindas Bolanos, Harold Brommer, Miguel Castilho, Alexandro Ribeiro, J P A M van Loon, Anneloes Mensinga, Mattie H P Van Rijen, Jos Malda, René van Weeren
<u><b>Objective</b></u> To evaluate the use of commercial and autologous fibrin glue and of an alternative method based on a 3D-printed polycaprolactone (PCL) anchor for the fixation of hydrogel-based scaffolds in an equine model for cartilage repair. <u><b>Methods</b></u> In a first study, three different hydrogel-based materials were orthotopically implanted in nine horses for 1-4 weeks in 6mm diameter full thickness cartilage defects in the medial femoral trochlear ridge and fixated with commercially available fibrin glue (CFG)...
August 10, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28772451/marginal-accuracy-and-internal-fit-of-3-d-printing-laser-sintered-co-cr-alloy-copings
#19
Myung-Joo Kim, Yun-Jung Choi, Seong-Kyun Kim, Seong-Joo Heo, Jai-Young Koak
Laser sintered technology has been introduced for clinical use and can be utilized more widely, accompanied by the digitalization of dentistry and the development of direct oral scanning devices. This study was performed with the aim of comparing the marginal accuracy and internal fit of Co-Cr alloy copings fabricated by casting, CAD/CAM (Computer-aided design/Computer-assisted manufacture) milled, and 3-D laser sintered techniques. A total of 36 Co-Cr alloy crown-copings were fabricated from an implant abutment...
January 23, 2017: Materials
https://www.readbyqxmd.com/read/28766199/a-patient-specific-3d-printed-form-accurately-transfers-supine-mri-derived-tumor-localization-information-to-guide-breast-conserving-surgery
#20
Richard J Barth, Venkataramanan Krishnaswamy, Keith D Paulsen, Timothy B Rooney, Wendy A Wells, Elizabeth Rizzo, Christina V Angeles, Jonathan D Marotti, Rebecca A Zuurbier, Candice C Black
BACKGROUND: Wire-localized excision of nonpalpable breast cancer is imprecise, resulting in positive margins 25-30% of the time. METHODS: Patients underwent preoperative supine magnetic resonance imaging (MRI). A radiologist outlined the tumor edges on consecutive images, creating a three-dimensional (3D) view of its location. Using 3D printing, a bra-like plastic form (the Breast Cancer Locator [BCL]) was fabricated, with features that allowed a surgeon to (1) mark the edges of the tumor on the breast surface; (2) inject blue dye into the breast 1 cm from the tumor edges; and (3) place a wire in the tumor at the time of surgery...
August 1, 2017: Annals of Surgical Oncology
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