keyword
MENU ▼
Read by QxMD icon Read
search

VZV

keyword
https://www.readbyqxmd.com/read/28443092/disarming-cellular-alarm-systems-manipulation-of-stress-induced-nkg2d-ligands-by-human-herpesviruses
#1
REVIEW
Dominik Schmiedel, Ofer Mandelboim
The coevolution of viruses and their hosts led to the repeated emergence of cellular alert signals and viral strategies to counteract them. The herpesvirus family of viruses displays the most sophisticated repertoire of immune escape mechanisms enabling infected cells to evade immune recognition and thereby maintain infection. The herpesvirus family consists of nine viruses that are capable of infecting humans: herpes simplex virus 1 and 2 (HSV-1, HSV-2), varicella zoster virus (VZV), Epstein-Barr virus (EBV), human cytomegalovirus (HCMV), roseoloviruses (HHV-6A, HHV-6B, and HHV-7), and Kaposi's-sarcoma-associated herpesvirus (KSHV)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28439065/multidisciplinary-study-of-the-secondary-immune-response-in-grandparents-re-exposed-to-chickenpox
#2
B Ogunjimi, J Van den Bergh, P Meysman, S Heynderickx, K Bergs, H Jansen, E Leuridan, A Vorsters, H Goossens, K Laukens, N Cools, Viggo Van Tendeloo, N Hens, P Van Damme, Evelien Smits, Ph Beutels
Re-exposure to chickenpox may boost varicella-zoster virus (VZV) immunity in the elderly. This secondary immune response is hypothesized to confer protection against herpes zoster. We longitudinally sampled 36 adults over the course of one year after re-exposure to chickenpox. The resulting 183 samples and those of 14 controls were assessed for VZV-specific T-cell immunity and antibody titres. The percentages of VZV-specific CD4+ IL-2-producing T-cells were increased in re-exposed grandparents compared to control participants up to 9 months after re-exposure...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28417331/use-of-high-dose-oral-valacyclovir-during-an-intravenous-acyclovir-shortage-a-retrospective-analysis-of-tolerability-and-drug-shortage-management
#3
Milena M McLaughlin, Sarah H Sutton, Ashley O Jensen, John S Esterly
INTRODUCTION: In late 2011, a shortage of IV acyclovir led to the need to empirically substitute high-dose oral valacyclovir (HDVA) to conserve IV acyclovir for patients with confirmed herpes simplex virus (HSV) meningitis or encephalitis. This report describes the management of the most recent national IV acyclovir shortage by the Antimicrobial Stewardship Program (ASP) at Northwestern Memorial Hospital (NMH), Chicago, IL, USA, and the use of HDVA. Secondarily, we assessed the safety and tolerability of HDVA as an alternate to IV acyclovir during this shortage...
April 17, 2017: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/28412076/original-article-varicella-vaccination-elicits-a-humoral-and-cellular-response-in-children-with-rheumatic-diseases-using-immune-suppressive-treatment
#4
Noortje Groot, Gecilmara Pileggi, Cleonice B Sandoval, Ingrid Grein, Guy Berbers, Virginia Paes Leme Ferriani, Nico Wulffraat, Sytze de Roock
OBJECTIVE: To assess humoral and cellular responses to live-attenuated varicella zoster virus (VZV) vaccination of patients with juvenile idiopathic arthritis (JIA), juvenile dermatomyositis (JDM) or juvenile scleroderma (JScle) compared to those of healthy controls (HC). METHODS: Before, 4-6weeks and one year after VZV vaccination, blood samples of patients and HC were collected. VZV-specific antibody concentrations were measured by ELISA and multiplex immune-assay...
April 12, 2017: Vaccine
https://www.readbyqxmd.com/read/28408118/a-novel-combined-vaccine-based-on-monochimeric-vlp-co-displaying-multiple-conserved-epitopes-against-enterovirus-71-and-varicella-zoster-virus
#5
Yangtao Wu, Rui Zhu, Longfa Xu, Yongchao Li, Shuxuan Li, Hai Yu, Shaowei Li, Hua Zhu, Tong Cheng, Ningshao Xia
Chicken pox and hand, foot and mouth disease (HFMD) are two major infectious diseases that mainly affect infants and children, causing significant morbidity annually. Varicella-zoster virus (VZV) and enterovirus 71 (EV71), respectively, are the principal epidemic pathogens causing these two diseases. To investigate the possibility of developing a novel combined vaccine to prevent chicken pox and HFMD, we constructed three chimeric virus-like particles (VLPs) (termed HBc-V/1/2, HBc-2/V/1 and HBc-1/2/V) based on the hepatitis B core antigen (HBc) carrier that display epitopes derived from VZV-gE, EV71-VP1, and EV71-VP2 in a varied tandem manner...
May 9, 2017: Vaccine
https://www.readbyqxmd.com/read/28400201/inhibitors-of-dual-specificity-tyrosine-phosphorylation-regulated-kinases-dyrk-exert-a-strong-anti-herpesviral-activity
#6
Corina Hutterer, Jens Milbradt, Stuart Hamilton, Mirko Zaja, Johann Leban, Christophe Henry, Daniel Vitt, Mirjam Steingruber, Eric Sonntag, Isabel Zeitträger, Hanife Bahsi, Thomas Stamminger, William Rawlinson, Stefan Strobl, Manfred Marschall
Infection with human cytomegalovirus (HCMV) is a serious medical problem, particularly in immunocompromised individuals and neonates. The success of (val)ganciclovir therapy is hampered by low drug compatibility and induction of viral resistance. A novel strategy of antiviral treatment is based on the exploitation of cell-directed signaling, e. g. pathways with a known relevance for carcinogenesis and tumor drug development. Here we describe a principle for putative antiviral drugs based on targeting dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs)...
April 9, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28397477/real-time-pcr-detection-of-the-most-common-bacteria-and-viruses-causing-meningitis
#7
Oya Akkaya, Hulya Iren Guvenc, Serife Yuksekkaya, Aysegul Opus, Asuman Guzelant, Meral Kaya, Muhammet Guzel Kurtoglu, Nurettin Kaya
BACKGROUND: Central nervous system (CNS) infections require prompt diagnosis, as the clinical condition progresses rapidly and may lead to severe permanent sequelae or death. The causative agents include viruses, bacteria, fungi, and parasites. In this study, samples with the diagnosis of CNS infection based on cerebrospinal fluid (CSF) sent to us from other hospitals/labs, were studied by multiplex real-time Polymerase Chain Reaction (PCR) method. The purpose of this study is to demonstrate, retrospectively, the most common bacteria and viruses causing meningitis and seasonal distribution of these agents using the multiplex real-time PCR method in CSF samples...
April 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28393250/inhibition-of-varicella%C3%A2-zoster-virus-replication-by-an-ethanol-extract-of-lysimachia-mauritiana
#8
Sohee Bae, Yoon-Jae Song
Varicella‑zoster virus (VZV), a ubiquitous human α‑herpesvirus, is the causative agent of chickenpox and shingles. In the present study, we investigated the antiviral activity of a 70% ethanol extract of Lysimachia mauritiana (LME) against VZV. LME strongly interfered with the replication of both laboratory and clinical strains of VZV without affecting the viability of MRC‑5 cells. Moreover, LME treatment suppressed the expression of an essential viral transactivator, immediate‑early 62 protein (IE62), in addition to other lytic genes in the later phases of viral replication...
April 7, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28388396/acute-facial-nerve-palsy-with-ipsilateral-soft-palate-ulcers
#9
C Mauprivez, C Comte, M Labrousse, R H Khonsari
Ramsay-Hunt syndrome (RHS) is a rare complication of herpes zoster in which reactivation of latent varicella zoster virus (VZV) infection occurs in the geniculate ganglion. Major clinical findings are peripheral facial nerve palsy accompanied by ipsilateral ear pain and erythematous vesicular rash on the external ear (herpes zoster oticus) and in the mouth. Thus, diagnosis of RHS is usually clinical. However, auricular herpetic eruption is not always present, making diagnosis more difficult. This report describes a case of RHS with left facial palsy without skin lesions in 60-year-old woman...
March 14, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28383421/varicella-zoster-virus-infection-after-allogeneic-hematopoietic-cell-transplantation-in-children-using-a-relatively-short-duration-of-acyclovir-prophylaxis-a-retrospective-study
#10
Seung Beom Han, Seong Koo Kim, Jae Wook Lee, Dong-Gun Lee, Nack-Gyun Chung, Dae Chul Jeong, Bin Cho, Jin-Han Kang
Although acyclovir prophylaxis against varicella zoster virus (VZV) infection for ≥1 year is recommended after allogeneic hematopoietic cell transplantation (HCT), the emergence of acyclovir-resistant viruses and adverse drug effects cannot be ignored. We investigated the cumulative incidence of VZV infection after allogeneic HCT in children receiving a shorter duration of acyclovir prophylaxis than recommended and evaluated the appropriateness of the short duration of acyclovir prophylaxis.Medical records of 217 children who received allogeneic HCT were retrospectively reviewed until a median of 25 months (range = 1-59 months) after HCT...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28381144/varicella-zoster-virus-gastritis
#11
Erik W Nohr, Doha M Itani, Christopher N Andrews, Margaret M Kelly
We report varicella-zoster virus (VZV) gastritis in a 70-year-old woman postchemotherapy for lymphoma, presenting with abdominal pain, vomiting, and delirium without rash. A gastric biopsy demonstrated viral inclusions but posed a diagnostic challenge as immunohistochemistry for cytomegalovirus and herpes simplex virus were negative, and VZV immunohistochemistry was not available. The patient developed a vesicular rash 7 days after her symptoms began. Molecular testing of the gastric biopsy and a skin swab both confirmed VZV infection...
March 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28379413/quantitative-phenotypical-and-functional-characterization-of-cellular-immunity-in-pediatric-individuals-with-down-syndrome
#12
Justine Schoch, Tilman R Rohrer, Michael Kaestner, Hashim Abdul-Khaliq, Ludwig Gortner, Urban Sester, Martina Sester, Taina Schmidt
Background: Infections and autoimmune disorders are more frequent in Down syndrome, suggesting abnormality of adaptive immunity. While the role of B-cells and antibodies is well characterized, knowledge regarding T-cells is limited. Methods: Lymphocyte subpopulations of 40 children and adolescents with Down syndrome and 51 controls were quantified, and phenotype and functionality of antigen-specific effector T-cells were flow-cytometrically analyzed after polyclonal and pathogen-specific stimulation (varicella-zoster virus (VZV), cytomegalovirus (CMV))...
April 4, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28368532/tlr3-mutations-in-adult-patients-with-herpes-simplex-virus-and-varicella-zoster-virus-encephalitis
#13
Manuela Sironi, Anna Maria Peri, Rachele Cagliani, Diego Forni, Stefania Riva, Mara Biasin, Mario Clerici, Andrea Gori
Defects in genes of the TLR3 pathway are associated with susceptibility to HSV-1 encephalitis (HSE). We analyzed a cohort of 11 adult Italian patients who developed viral encephalitis. We detected two rare missense mutations in TLR3: one in a HSE patient (p.Leu297Val ) and the other in an individual with VZV encephalitis (p.Leu199Phe). Both mutations are extremely rare in human populations and have pathogenicity scores highly suggestive of a functional effect. Data herein expand the phenotypic spectrum of TLR3 mutations to VZV encephalitis and support the role of TLR3 genetic defects as risk factors for herpesvirus encephalitis in adults...
March 27, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28367398/varicella-zoster-virus-glycoproteins-entry-replication-and-pathogenesis
#14
Stefan L Oliver, Edward Yang, Ann M Arvin
Varicella-zoster virus (VZV), an alphaherpesvirus that causes chicken pox (varicella) and shingles (herpes zoster), is a medically important pathogen that causes considerable morbidity and, on occasion, mortality in immunocompromised patients. Herpes zoster can afflict the elderly with a debilitating condition, postherpetic neuralgia, triggering severe, untreatable pain for months or years. The lipid envelope of VZV, similar to all herpesviruses, contains numerous glycoproteins required for replication and pathogenesis...
December 2016: Current Clinical Microbiology Reports
https://www.readbyqxmd.com/read/28366586/intramuscularly-administered-herpes-zoster-subunit-vaccine-has-no-effects-on-fertility-pre-and-post-natal-development-in-sprague-dawley-rats
#15
Lawrence Segal, Karen Thacker, Michel Fochesato, Giulia Giordano, Nathalie Garçon, Eric Destexhe
The herpes zoster subunit vaccine (HZ/su) is an investigational vaccine for the prevention of shingles, a disease caused by the varicella zoster virus (VZV). It is composed of recombinant VZV glycoprotein E (gE) and AS01. We assessed the potential toxic effects of gE/AS01 and AS01 alone on female and male fertility, and on embryo-fetal, pre- and post-natal development in Sprague-Dawley rats. Females were immunized before pairing and during gestation. Half of the pregnant rats were used for embryo-fetal investigations...
March 31, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28361207/antibody-response-to-paramyxoviruses-in-paget-s-disease-of-bone
#16
Micaela Rios Visconti, Ricardo Usategui-Martín, Stuart H Ralston
Paget's disease of bone (PDB) is a common skeletal disorder characterised by focal abnormalities of increased and disorganised bone turnover. Genetic factors play a central role in the pathogenesis of PDB but environmental factors also contribute. Measles virus (MV), respiratory syncytial virus (RSV) and canine distemper virus (CDV) have all been implicated as potential disease triggers but the data are conflicting. Since chronic paramyxovirus infection with measles is known to be accompanied by increased production of antiviral antibodies, we have analysed circulating concentrations of antibodies to MV, CDV, and RSV as well as mumps, rubella and varicella zoster virus (VZV) in 463 patients with PDB and 220 aged and gender-matched controls...
March 31, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28359621/varicella-seroepidemiology-in-united-states-air-force-recruits-a-retrospective-cohort-study-comparing-immunogenicity-of-varicella-vaccination-and-natural-infection
#17
Joshua R Duncan, Catherine T Witkop, Bryant J Webber, Amy A Costello
BACKGROUND/OBJECTIVES: Infection with varicella zoster virus (VZV) produces lifelong immunity, but duration of post-vaccination immunity has not been established. The purpose of this study is to determine if a difference exists in the long-term seropositivity of anti-VZV antibodies in a cohort of young adults who were vaccinated against varicella as compared to a similar cohort with a history of chickenpox disease, and to determine which variables best predict waning seropositivity following varicella vaccination...
March 27, 2017: Vaccine
https://www.readbyqxmd.com/read/28358222/valacyclovir-as-initial-treatment-for-acute-retinal-necrosis-a-pharmacokinetic-modeling-and-simulation-study
#18
Tao Liu, Aabha Jain, Michael Fung, Christopher Vinnard, Vijay Ivaturi
PURPOSE: Acute retinal necrosis (ARN) is a feared complication of infectious retinitis most commonly caused by varicella zoster virus (VZV). We performed a pharmacokinetic modeling and simulation study by integrating the existing understanding of physiology with previously published data to evaluate the vitreal penetration of oral valacyclovir for the treatment of ARN, under various dosing scenarios. METHOD: We compared different oral valacyclovir dosing regimens with intravenous acyclovir...
March 30, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28356523/orf7-of-varicella-zoster-virus-is-required-for-viral-cytoplasmic-envelopment-in-differentiated-neuronal-cells
#19
Hai-Fei Jiang, Wei Wang, Xuan Jiang, Wen-Bo Zeng, Zhang-Zhou Shen, Yi-Ge Song, Hong Yang, Xi-Juan Liu, Xiao Dong, Jing Zhou, Jin-Yan Sun, Fei-Long Yu, Lin Guo, Tong Cheng, Simon Rayner, Fei Zhao, Hua Zhu, Min-Hua Luo
Although a varicella-zoster virus (VZV) vaccine has been used for many years, the neuropathy caused by VZV infection is still a major health concern. ORF7 of VZV has been recognized as a neurotropic gene in vivo, but its neurovirulent role remains unclear. In the present study, we investigated the effect of ORF7 deletion on VZV replication cycle at virus entry, genome replication, gene expression, capsid assembly and cytoplasmic envelopment, and transcellular transmission in differentiated neural progenitor cells (dNPCs) and neuroblastoma SH-SY5Y (dSY5Y) cells...
March 29, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28341533/epidemiology-of-infectious-encephalitis-causes-in-2016
#20
REVIEW
A Boucher, J L Herrmann, P Morand, R Buzelé, Y Crabol, J P Stahl, A Mailles
We performed a literature search in the Medline database, using the PubMed website. The incidence of presumably infectious encephalitis is estimated at 1.5-7 cases/100,000 inhabitants/year, excluding epidemics. Infectious encephalitis and immune-mediated encephalitis share similar clinical signs and symptoms. The latter accounts for a significant proportion of presumably infectious encephalitis cases without any established etiological diagnosis; as shown from a prospective cohort study where 21% of cases were due to an immune cause...
March 22, 2017: Médecine et Maladies Infectieuses
keyword
keyword
52417
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"