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https://www.readbyqxmd.com/read/27918431/evaluation-of-microrna-expression-in-patients-with-herpes-zoster
#1
Xihan Li, Ying Huang, Yucheng Zhang, Na He
Reactivated varicella-zoster virus (VZV), which lies latent in the dorsal root ganglions and cranial nerves before its reactivation, is capable of causing herpes zoster (HZ), but the specific mechanism of virus reactivation and latency remains unknown. It was proposed that circulating microRNAs (miRNAs) in body fluids could potentially indicate infection. However, the connection between herpes zoster and circulating miRNAs has not been demonstrated. In this study, 41 HZ patients without superinfection were selected...
December 2, 2016: Viruses
https://www.readbyqxmd.com/read/27918378/safety-of-infliximab-following-live-virus-vaccination-in-kawasaki-disease-patients
#2
Aaron M Lee, Jane C Burns, Adriana H Tremoulet
No published data are available regarding infliximab use in Kawasaki Disease (KD) patients with recent live virus vaccination. We investigated 38 acute KD patients who received infliximab within 90 days of receiving MMR, VZV, or Rotavirus vaccines. There were no adverse events or serious infections, which suggests that infliximab use in acute KD patients with recent live viral vaccinations is safe.
December 1, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27911430/-clinical-presentations-of-herpes-zoster-ophthalmicus-diagnosis-and-therapy
#3
G M Chernakova, E A Kleshcheva, T B Semenova
: Approximately a quarter of the world's population at some point in life is at risk of developing shingles (Herpes Zoster). In 10-20% of cases the first branch of the trigeminal nerve gets involved (Herpes Zoster Ophthalmicus, HZO). Ophthalmic complications of HZO are able to cause a significant reduction in visual function. AIM: To study and summarize clinical features of HZO (including the rate of complications and their nature) and to determine the relationship between clinical and laboratory data from these patients...
2016: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/27901620/etiology-and-clinical-features-of-ocular-inflammatory-diseases-in-a-tertiary-referral-centre-in-sydney-australia
#4
Sophia L Zagora, Richard Symes, Aaron Yeung, Will Yates, Denis Wakefield, Peter J McCluskey
PURPOSE: To report the pattern of uveitis in patients attending a tertiary uveitis service in Sydney, Australia. METHODS: The charts of patients seen between January 2009 and December 2015 were retrospectively reviewed. Data pertaining to patient demographics, eye examination on presentation, work-up and final diagnoses were collected. RESULTS: The total number of patients with uveitis seen over this period was 1165. There were 650 males (56%) and 515 females (44%)...
November 30, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27899225/humoral-and-cellular-response-after-varicella-vaccination-in-vzv-igg-seronegative-kidney-transplant-candidates
#5
Marcia M L Kho, Joke M Zuijderwijk, Annemiek A van der Eijk, Ronella de Kuiper, Marieken J Boer-Verschragen, Willem Weimar, Nicole M van Besouw
BACKGROUND: In immunocompromised patients, primary infection with VZV may have a disastrous clinical course. Vaccination of VZV-seronegative patients on the waiting list for renal transplantation may prevent severe disease. However, the immunologic response of end-stage renal disease patients to peptide vaccines is far from optimal. Our question was whether end-stage renal disease patients with undetectable VZV-IgG levels were able to mount an adequate humoral and cellular response to a live attenuated varicella vaccine...
November 26, 2016: Vaccine
https://www.readbyqxmd.com/read/27896415/predicting-risk-factors-for-varicella-zoster-virus-infection-and-postherpetic-neuralgia-after-hematopoietic-cell-transplantation-using-ordered-logistic-regression-analysis
#6
Yuko Kanbayashi, Yosuke Matsumoto, Junya Kuroda, Tsutomu Kobayashi, Shigeo Horiike, Toyoshi Hosokawa, Masafumi Taniwaki
To identify risk factors for varicella zoster virus (VZV) infection and postherpetic neuralgia (PHN) after hematopoietic cell transplantation (HCT), we conducted a retrospective chart review of 163 consecutive patients who underwent HCT between November 2004 and July 2014. Overall, the male/female (M/F) ratio was 80/83, median age at HCT was 54 (range 15-69) years, and autologous/allogeneic HCT (auto/allo-HCT) ratio was 71/92. Forty-four patients [M/F, 25/19; median age, 57 (range: 16-68) years; auto/allo-HCT, 26/18] developed VZV infection after HCT...
November 28, 2016: Annals of Hematology
https://www.readbyqxmd.com/read/27883372/a-case-of-transverse-myelitis-caused-by-varicella-zoster-virus-in-an-immunocompetent-older-patient
#7
Jeong Eun Lee, Shinwon Lee, Kye Hyung Kim, Hee Ryeong Jang, Young Joo Park, Jin Suk Kang, Sung Yong Han, Sun Hee Lee
Varicella zoster virus (VZV) is a human neurotropic alphaherpesvirus that causes chickenpox (varicella) in children. VZV reactivation may lead to neurological complications, including transverse myelitis. However, transverse myelitis caused by VZV reactivation is rare in immunocompetent patients. Herein, we report a case of transverse myelitis caused by VZV in an immunocompetent older patient, and confirmed this case by polymerase chain reaction. A 79-year-old woman visited our service with complaints of weakness in the right lower leg, generalized vesicular eruptions, and throbbing pain in the right flank for ten days...
November 11, 2016: Infection & Chemotherapy
https://www.readbyqxmd.com/read/27880853/risk-of-stroke-after-herpes-zoster-evidence-from-a-german-self-controlled-case-series-study
#8
Tania Schink, Sigrid Behr, Kathrin Thöne, Hélène Bricout, Edeltraut Garbe
BACKGROUND: Herpes zoster (HZ) is caused by reactivation of the latent varicella-zoster virus (VZV). A severe complication of HZ is VZV vasculopathy which can result in ischemic or hemorrhagic stroke. The aims of our study were to assess the risk of stroke after the onset of HZ and to investigate the roles of stroke subtype, HZ location and the time interval between HZ onset and stroke. METHODS: A self-controlled case-series study was performed on a cohort of patients with incident stroke recorded in the German Pharmacoepidemiological Research Database (GePaRD), which covers about 20 million persons throughout Germany...
2016: PloS One
https://www.readbyqxmd.com/read/27879555/safety-and-immunogenicity-of-dtap5-ipv-compared-with-dtap5-plus-ipv-as-the-fifth-dose-in-children-4-to-6-years-of-age
#9
Michael J Smith, Emilia Jordanov, Xiaohua Sheng, Peter H Tsang
BACKGROUND: Immunogenicity and safety of stand-alone diphtheria, tetanus toxoid, 5-component acellular pertussis vaccine adsorbed, inactivated poliovirus (IPV) combination vaccine (DTaP5-IPV) was compared with separate DTaP5 plus IPV vaccines as fifth dose in children 4-6 years of age. METHODS: In this phase III, controlled, multicenter, randomized, open-label study participants were randomized to DTaP5-IPV plus measles/mumps/rubella (MMR) and varicella virus (VZV) vaccines (Group 1; N=324), DTaP5+IPV with MMR and VZV (Group 2; N=327), DTaP5-IPV with/without MMR/VZV (Group 3; N=2419), or DTaP5+IPV with/without MMR/VZV (Group 4; N=302)...
November 22, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27870601/t-cell-immunity-to-varicella-zoster-virus-in-the-setting-of-advanced-hiv-and-multiple-varicella-zoster-virus-recurrences
#10
Rachel A Bender Ignacio, Meena S Ramchandani, Kerry J Laing, Christine M Johnston, David M Koelle
A woman presented with at least four manifestations of varicella-zoster virus (VZV) infection, including central nervous system vasculitis, during her first 2 years of HIV infection. We evaluated her CD4 T cell responses to VZV given the infrequency with which multiple recurrences of VZV occurred, especially following immune reconstitution on antiretroviral therapy.
November 21, 2016: Viral Immunology
https://www.readbyqxmd.com/read/27835757/vaccine-strain-herpes-zoster-found-in-the-trigeminal-nerve-area-in-a-healthy-child-a-case-report
#11
Sayaka Iwasaki, Kouji Motokura, Yoshitaka Honda, Masamitsu Mikami, Daisuke Hata, Atsuko Hata
A previously healthy 2-year-old girl, vaccinated for varicella at 17 months, was admitted because of left-sided facial herpes zoster caused by vaccine-strain varicella-zoster virus (VZV). She recovered fully with no complication after intravenous treatment using acyclovir. Earlier reports have described that herpes zoster (HZ) rashes caused by vaccine-strain VZV tend to occur on the dermis corresponding to the skin area where the varicella vaccine was received. However, rashes appeared on this girl only in the trigeminal nerve area, which is unrelated to the vaccinated site...
November 3, 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27803408/varicella-reinfection-with-unilateral-varicella-pneumonia
#12
Ryo Ariyasu, Kazuhiko Nakagawa, Naoya Ikegami, Chisato Konishi, Satoshi Nakao, Tomoko Funazo, Masato Taki, Kyohei Morita, Moon Hee Hwang, Chie Yoshimura, Toshiaki Wakayama, Yasuo Nishizaka
Varicella zoster virus (VZV) infection does not always provide lifelong immunity. A reinfection with VZV occurs more commonly than previously thought. Varicella infection spreads through the blood-stream, causing pneumonia. Varicella pneumonia results in bilateral pulmonary nodular infiltrations. We herein report a case of varicella reinfection with unilateral varicella pneumonia in which a reduced pulmonary blood flow due to radiation damage was considered to be the cause of unilateral pneumonia. In patients with an asymmetric pulmonary blood flow, careful interpretation of unilateral infiltration is therefore considered to be important with making a differential diagnosis...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27799874/enhanced-viral-replication-by-cellular-replicative-senescence
#13
Ji-Ae Kim, Rak-Kyun Seong, Ok Sarah Shin
Cellular replicative senescence is a major contributing factor to aging and to the development and progression of aging-associated diseases. In this study, we sought to determine viral replication efficiency of influenza virus (IFV) and Varicella Zoster Virus (VZV) infection in senescent cells. Primary human bronchial epithelial cells (HBE) or human dermal fibroblasts (HDF) were allowed to undergo numbers of passages to induce replicative senescence. Induction of replicative senescence in cells was validated by positive senescence-associated β-galactosidase staining...
October 2016: Immune Network
https://www.readbyqxmd.com/read/27795427/the-glycoprotein-b-cytoplasmic-domain-lysine-cluster-is-critical-for-varicella-zoster-virus-cell-cell-fusion-regulation-and-infection
#14
Edward Yang, Ann M Arvin, Stefan L Oliver
: The conserved glycoproteins gB and gH-gL are essential for herpesvirus entry and cell-cell fusion induced syncytia formation, a characteristic of Varicella Zoster Virus (VZV) pathology in skin and sensory ganglion. VZV syncytia formation, which has been implicated in the painful condition of postherpetic neuralgia, is regulated by the cytoplasmic domains of gB (gBcyt) via an immunoreceptor tyrosine-based inhibition motif (ITIM) and gH (gHcyt). A lysine cluster (K894, K897, K898, and K900) in the VZV gBcyt was identified by sequence alignment to be conserved among alphaherpesviruses suggesting a functional role...
October 26, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27795423/dysregulated-glycoprotein-b-mediated-cell-cell-fusion-disrupts-varicella-zoster-virus-and-host-gene-transcription-during-infection
#15
Stefan L Oliver, Edward Yang, Ann M Arvin
: The highly conserved herpesvirus glycoprotein complex, gB/gH-gL, mediates membrane fusion during virion entry and cell-cell fusion. Varicella-zoster virus (VZV) characteristically forms multi-nucleated cells, or syncytia, during the infection of human tissues but little is known about this process. The cytoplasmic domain of VZV gB (gBcyt) has been implicated in cell-cell fusion regulation because a gB[Y881F] substitution causes hyperfusion. The gBcyt regulation is necessary for VZV pathogenesis as the hyperfusogenic mutant gB[Y881F] is severely attenuated in human skin xenografts...
October 26, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27792200/synthesis-and-the-biological-activity-of-phosphonylated-1-2-3-triazolenaphthalimide-conjugates
#16
Iwona E Głowacka, Rafał Gulej, Piotr Grzonkowski, Graciela Andrei, Dominique Schols, Robert Snoeck, Dorota G Piotrowska
A novel series of diethyl {4-[(5-substituted-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-methyl]-1H-1,2,3-triazol-1-yl}alkylphosphonates designed as analogues of amonafide was synthesized. All phosphonates were assessed for antiviral activity against a broad range of DNA and RNA viruses and several of them showed potency against varicella-zoster virus (VZV) [EC50 (50% effective concentration) = 27.6-91.5 μM]. Compound 16b exhibited the highest activity against a thymidine kinase-deficient (TK(-)) VZV strain (EC50 = 27...
October 26, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27780480/measles-mumps-rubella-and-vzv-importance-of-serological-testing-of-vaccine-preventable-diseases-in-young-adults-living-with-hiv-in-germany
#17
C Schwarze-Zander, R Draenert, C Lehmann, M Stecher, C Boesecke, S Sammet, J C Wasmuth, U Seybold, D Gillor, U Wieland, T Kümmerle, C P Strassburg, A Mankertz, A M Eis-Hübinger, G Jäger, G Fätkenheuer, J R Bogner, J K Rockstroh, J J Vehreschild
Measles, mumps, rubella (MMR) and varicella zoster virus (VZV) infection can cause serious diseases and complications in the HIV-positive population. Due to successful vaccination programmes measles, mumps and congenital rubella syndrome has become neglected in Germany. However, recent outbreaks of measles have occurred from import-associated cases. In this cross-sectional study the serostatus for MMR and VZV in 2013 HIV-positive adults from three different university outpatient clinics in Bonn (n = 544), Cologne (n = 995) and Munich (n = 474) was analysed...
October 26, 2016: Epidemiology and Infection
https://www.readbyqxmd.com/read/27772619/%C3%AE-herpes-virus-infections-among-renal-transplant-recipients
#18
REVIEW
Cybele Lara Abad, Raymund R Razonable
The α herpes viruses HSV-1, HSV-2, and VZV often reactivate in the setting of immune suppression after solid organ transplantation. Oral or genital mucocutaneous disease is the most common clinical manifestation of HSV disease while VZV manifests as varicella (or chickenpox) or reactivation herpes zoster, characterized by a diffuse rash, or a painful unilateral vesicular eruption in a dermatomal distribution, respectively. The diagnosis of HSV and VZV is primarily based on history and clinical presentation, although diagnostic tests may be necessary for atypical presentations of disease...
September 2016: Seminars in Nephrology
https://www.readbyqxmd.com/read/27764254/defective-t-memory-cell-differentiation-after-varicella-zoster-vaccination-in-older-individuals
#19
Qian Qi, Mary M Cavanagh, Sabine Le Saux, Lisa E Wagar, Sally Mackey, Jinyu Hu, Holden Maecker, Gary E Swan, Mark M Davis, Cornelia L Dekker, Lu Tian, Cornelia M Weyand, Jörg J Goronzy
Vaccination with attenuated live varicella zoster virus (VZV) can prevent zoster reactivation, but protection is incomplete especially in an older population. To decipher the molecular mechanisms underlying variable vaccine responses, T- and B-cell responses to VZV vaccination were examined in individuals of different ages including identical twin pairs. Contrary to the induction of VZV-specific antibodies, antigen-specific T cell responses were significantly influenced by inherited factors. Diminished generation of long-lived memory T cells in older individuals was mainly caused by increased T cell loss after the peak response while the expansion of antigen-specific T cells was not affected by age...
October 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27759349/cerebral-sinus-venous-thrombosis-as-a-rare-complication-of-primary-varicella-zoster-virus-infection
#20
K Gayathri, P K Ramalingam, Rpsp Santhakumar, B V Manjunath, N Karuppuswamy, B Vetriveran, S Selvamani, P Vishnuram, Kumar Natarajan
We present the case of a 23 year old with acute onset left hemiparesis and meningeal irritation, associated with recent history of chickenpox 15 days prior. Varicella-IgG and IgM was positive in the CSF and blood along with reduced serum/CSF ratios of VZV immunoglobulins. MRV showed thrombosis (CVT) of superior sagittal, transverse, right sigmoid sinuses with haemorrhagic infarct in right frontoparietal region. Patient responded well to intravenous heparin, Acyclovir and oral anticoagulant therapy.
July 2016: Journal of the Association of Physicians of India
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