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https://www.readbyqxmd.com/read/28090487/clinical-characteristics-and-outcomes-of-varicella-zoster-virus-infection-in-children-with-hematologic-malignancies-in-the-acyclovir-era
#1
Seul-Ki Kim, Min Chae Kim, Seung Beom Han, Seong Koo Kim, Jae Wook Lee, Nack-Gyun Chung, Bin Cho, Dae Chul Jeong, Jin Han Kang, Hack-Ki Kim
BACKGROUND: Although intravenous acyclovir therapy is recommended for varicella zoster virus (VZV) infection in immunocompromised children, the clinical characteristics and outcomes of VZV infection in the acyclovir era have rarely been reported. METHODS: The medical records of children diagnosed with varicella or herpes zoster virus, who had underlying hematologic malignancies, were retrospectively reviewed, and the clinical characteristics and outcomes of VZV infection were evaluated...
December 2016: Blood Research
https://www.readbyqxmd.com/read/28039960/preventive-strategies-against-cytomegalovirus-and-incidence-of-%C3%AE-herpesvirus-infections-in-olid-organ-transplant-recipients-a-nationwide-cohort-study
#2
Cecilia Martin-Gandul, Susanne Stampf, Delphine Héquet, Nicolas J Mueller, Alexia Cusini, Christian van Delden, Nina Khanna, Katia Boggian, Cédric Hirzel, Paola Soccal, Hans H Hirsch, Manuel Pascual, Pascal Meylan, Oriol Manuel
We assessed the impact of antiviral preventive strategies on the incidence of herpes-simplex virus (HSV) and varicella-zoster virus (VZV) infections in a nationwide cohort of transplant recipients. Risk factors for the development of HSV/VZV infection were assessed by Cox PH regression. We included 2781 patients (56% kidney, 20% liver, 10% lung, 7.3% heart, 6.7% others). Overall, 1264 (45%) patients received antiviral prophylaxis [(val)ganciclovir (n=1126) or (val)acyclovir (n=138)]. Incidences for HSV and VZV infections were 28...
December 31, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/28039754/herpes-zoster-in-autologous-hematopoietic-cell-transplant-recipients-in-the-era-of-acyclovir-or-valacyclovir-prophylaxis-and-novel-treatment-and-maintenance-therapies
#3
Farah Sahoo, Joshua Aiden Hill, Hu Xie, Wendy Leisenring, Jessica Yi, Sonia Goyal, Louise E Kimball, Ingi Lee, Sachiko Seo, Chris Davis, Stephen A Pergam, Mary E Flowers, Kai-Li Liaw, Leona Holmberg, Michael Boeckh
The epidemiology of herpes zoster (HZ) in contemporary autologous hematopoietic cell transplant (HCT) recipients, and the impact of acyclovir (ACV)/valacyclovir (VACV) prophylaxis, is not well described. In this observational study from 2002 to 2010, we retrospectively identified 1000 varicella zoster virus (VZV)-seropositive autologous HCT recipients with up to 5 years of follow-up. The incidence of HZ and use of ACV/VACV prophylaxis were determined through review of medical records and mailed questionnaires...
December 28, 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28033514/infections-due-to-alphaherpesviruses-in-early-post-transplant-period-after-allogeneic-haematopoietic-stem-cell-transplantation-results-of-a-5-year-survey
#4
Maciej Przybylski, Anna Majewska, Tomasz Dzieciatkowski, Patrycja Rusicka, Grzegorz W Basak, Barbara Nasilowska-Adamska, Jaroslaw Bilinski, Wieslaw W Jedrzejczak, Marta Wroblewska, Kazimierz Halaburda, Grazyna Mlynarczyk, Agnieszka Tomaszewska
BACKGROUND: Infections caused by human α-herpesviruses usually have a benign course with recurrencies. However, they may become dangerous in immunocompromised hosts. In this case, molecular methods constitute a reliable diagnostic tool enabling rapid assessment of the efficacy of antiviral treatment strategies. OBJECTIVES: We estimated the frequency of alphaherpesviral DNAemia and the viral load during early post-transplantation period after alloHSCT; we also analyzed association of the DNAemia and chosen parameters of the patients...
December 21, 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28027004/has-vzv-epidemiology-changed-in-italy-results-of-a-seroprevalence-study
#5
Antonella De Donno, Parvanè Kuhdari, Marcello Guido, Maria Cristina Rota, Antonino Bella, Giordana Brignole, Silvia Lupi, Adele Idolo, Armando Stefanati, Martina Del Manso, Giovanni Gabutti
The aim of the study was to evaluate if and how varicella prevalence has changed in Italy. In particular a seroprevalence study was performed, comparing it to similar surveys conducted in pre-immunization era. During 2013-2014, sera obtained from blood samples taken for diagnostic purposes or routine investigations were collected in collaboration with at least one laboratory/center for each region, following the approval of the Ethics Committee. Data were stratified by sex and age. All samples were processed in a national reference laboratory by an immunoassay with high sensitivity and specificity...
December 27, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28025408/a-case-of-anti-aquapolin-4-antibody-positive-myelitis-with-hyperhidrosis-following-herpes-zoster
#6
Machiko Suda, Michiko Tsutsumiuchi, Yoshikazu Uesaka, Nobukazu Hayashi
We report an acute myelitis in a 53-year-old woman that occurred in 7 days after the diagnosis of Th5-6 herpes zoster. Clinical examination revealed hyperhidrosis of left side of her face, neck, arm and upper chest. She also had muscle weakness of her left leg and sensory impairment for light touch and temperature in her chest and legs. Spinal cord MRI demonstrated a longitudinal T2-hyperintense lesion extending from Th1 to 7. In the axial imaging, the lesion dominantly located in the left side gray matter...
December 23, 2016: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/28011413/a-systematic-review-and-meta-analysis-of-seroprevalence-of-varicella-zoster-virus-a-nationwide-population-based-study
#7
REVIEW
Omolbanin Amjadi, Alireza Rafiei, Mohammadreza Haghshenas, Reza Alizadeh Navaei, Reza Valadan, Zahra Hosseini-Khah, Akbar Hedayatizadeh Omran, Mohsen Arabi, Reza Jafari Shakib, Tahoora Mousavi, G Hossein Ashrafi
Varicella zoster virus (VZV) causes chicken pox as a primary infection following which it becomes latent in neurons. It may then reactivate to cause shingles (herpes zoster). Severity of lesions and VZV pathogenicity are depended on the host's immune response and variant in VZV Dr Athina Myrto ChioniIdentification of VZV seroprevalance rate in general population may lead to develop new health strategic managements such as vaccination. Therefore, we aimed to provide a systematic review of the seroprevalence of VZV infection among Iranian population and estimate age- and gender- specific prevalence of VZV...
December 6, 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28007703/immunohistochemistry-is-rarely-justified-for-the-diagnosis-of-viral-infections
#8
Isaac H Solomon, Jason L Hornick, Alvaro C Laga
OBJECTIVES: To determine the utility of immunohistochemistry (IHC) for the diagnosis of viral infections in surgical pathology specimens lacking characteristic viral cytopathic effects. METHODS: Five years of cases at an academic medical center were reviewed for the use of IHC to detect cytomegalovirus (CMV), herpes simplex virus 1 and 2 (HSV-1 and HSV-2), varicella zoster virus (VZV), adenovirus, or polyomavirus (ie, BK or JC). RESULTS: In total, 1,636 viral IHC stains were ordered on 1,099 specimens from 957 cases...
December 21, 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28007549/estimation-of-age-specific-rates-of-reactivation-and-immune-boosting-of-the-varicella-zoster-virus
#9
Isabella Marinelli, Alies van Lier, Hester de Melker, Andrea Pugliese, Michiel van Boven
Studies into the impact of vaccination against the varicella zoster virus (VZV) have increasingly focused on herpes zoster (HZ), which is believed to be increasing in vaccinated populations with decreasing infection pressure. This idea can be traced back to Hope-Simpson's hypothesis, in which a person's immune status determines the likelihood that he/she will develop HZ. Immunity decreases over time, and can be boosted by contact with a person experiencing varicella (exogenous boosting) or by a reactivation attempt of the virus (endogenous boosting)...
November 22, 2016: Epidemics
https://www.readbyqxmd.com/read/27997521/laboratory-diagnosis-of-breakthrough-varicella-in-children
#10
Masahiro Watanabe, Hitoshi Ochiai, Masahiro Ito, Manami Negoro, Shigeru Suga, Toshiaki Ihara
BACKGROUND: Breakthrough varicella (BV) develops in vaccinated persons as a result of infection by wild-type varicella zoster virus (VZV) more than 42 days after varicella vaccination. The clinical symptoms are atypical and clinical diagnosis can be difficult. We investigated laboratory-based diagnostic methods that are relatively simple and highly precise in order to conduct accurate surveillance. SUBJECTS AND METHODS: We enrolled 42 patients with suspected BV at two pediatric hospitals, and performed real-time polymerase chain reaction (PCR) on the skin lesions to confirm the BV diagnosis...
December 15, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27989423/-diagnostic-and-therapeutic-contribution-of-microbiological-analysis-in-severe-microbial-keratitis-at-reims-university-hospital-between-2012%C3%A2-and-2014
#11
J Caliot, D Guindolet, A Ducasse, L Andreoletti, C Arndt
PURPOSE: To investigate the contribution of microbial analysis in the diagnosis and management of severe microbial keratitis. MATERIAL AND METHOD: This is a monocentric retrospective study at the University Hospital of Reims from January 2012 to December 2014. Corneal scrapings with infectious keratitis were subjected to routine bacterial and fungal culture. PCR was also performed to detect various viral DNA (VZV, CMV, EBV, HSV 1 & 2, adenovirus) and Acanthamoeba sp...
December 15, 2016: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/27973418/varicella-zoster-virus-infectious-cycle-er-stress-autophagic-flux-and-amphisome-mediated-trafficking
#12
REVIEW
Charles Grose, Erin M Buckingham, John E Carpenter, Jeremy P Kunkel
Varicella-zoster virus (VZV) induces abundant autophagy. Of the nine human herpesviruses, the VZV genome is the smallest (~124 kbp), lacking any known inhibitors of autophagy, such as the herpes simplex virus ICP34.5 neurovirulence gene. Therefore, this review assesses the evidence for VZV-induced cellular stress, endoplasmic-reticulum-associated degradation (ERAD), and autophagic flux during the VZV infectious cycle. Even though VZV is difficult to propagate in cell culture, the biosynthesis of the both N- and O-linked viral glycoproteins was found to be abundant...
December 10, 2016: Pathogens
https://www.readbyqxmd.com/read/27966015/oral-shedding-of-human-herpesviruses-in-patients-undergoing-radiotherapy-chemotherapy-treatment-for-head-and-neck-squamous-cell-carcinoma
#13
Michelle Palmieri, Victor Adriano de Oliveira Martins, Laura Masami Sumita, Tania Regina Tozetto-Mendoza, Bruna Baraldi Romano, Clarisse Martins Machado, Claudio Sergio Pannuti, Thaís Bianca Brandão, Ana Carolina Prado Ribeiro, Luciana Corrêa, Paulo Henrique Braz-Silva
OBJECTIVE: Opportunistic infections may affect the oral mucosa of patients undergoing radio/chemotherapy through exacerbation of oral mucositis. The aim of this study is to evaluate the oral shedding of all eight human herpesviruses and its possible association with oral mucositis. MATERIALS AND METHODS: In this prospective cohort study, we analyzed oral rinse samples, collected weekly, from 20 patients during radiotherapy treatment. Serologic status to HSV1 and HSV2, EBV, CMV, and VZV in three different periods was performed by ELISA assay...
December 14, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27935069/nerve-ultrasound-abnormalities-mirror-the-course-of-varicella-zoster-virus-sensory-motor-radiculoplexopathy
#14
Alessandro Salvalaggio, Mario Cacciavillani, Andrea Visentin, Marta Campagnolo, Livio Trentin, Chiara Briani
No abstract text is available yet for this article.
December 9, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27918431/evaluation-of-microrna-expression-in-patients-with-herpes-zoster
#15
Xihan Li, Ying Huang, Yucheng Zhang, Na He
Reactivated varicella-zoster virus (VZV), which lies latent in the dorsal root ganglions and cranial nerves before its reactivation, is capable of causing herpes zoster (HZ), but the specific mechanism of virus reactivation and latency remains unknown. It was proposed that circulating microRNAs (miRNAs) in body fluids could potentially indicate infection. However, the connection between herpes zoster and circulating miRNAs has not been demonstrated. In this study, 41 HZ patients without superinfection were selected...
December 2, 2016: Viruses
https://www.readbyqxmd.com/read/27918378/safety-of-infliximab-following-live-virus-vaccination-in-kawasaki-disease-patients
#16
Aaron M Lee, Jane C Burns, Adriana H Tremoulet
No published data are available regarding infliximab use in Kawasaki Disease (KD) patients with recent live virus vaccination. We investigated 38 acute KD patients who received infliximab within 90 days of receiving MMR, VZV, or Rotavirus vaccines. There were no adverse events or serious infections, which suggests that infliximab use in acute KD patients with recent live viral vaccinations is safe.
December 1, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27911430/-clinical-presentations-of-herpes-zoster-ophthalmicus-diagnosis-and-therapy
#17
G M Chernakova, E A Kleshcheva, T B Semenova
: Approximately a quarter of the world's population at some point in life is at risk of developing shingles (Herpes Zoster). In 10-20% of cases the first branch of the trigeminal nerve gets involved (Herpes Zoster Ophthalmicus, HZO). Ophthalmic complications of HZO are able to cause a significant reduction in visual function. AIM: To study and summarize clinical features of HZO (including the rate of complications and their nature) and to determine the relationship between clinical and laboratory data from these patients...
2016: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/27901620/etiology-and-clinical-features-of-ocular-inflammatory-diseases-in-a-tertiary-referral-centre-in-sydney-australia
#18
Sophia L Zagora, Richard Symes, Aaron Yeung, Will Yates, Denis Wakefield, Peter J McCluskey
PURPOSE: To report the pattern of uveitis in patients attending a tertiary uveitis service in Sydney, Australia. METHODS: The charts of patients seen between January 2009 and December 2015 were retrospectively reviewed. Data pertaining to patient demographics, eye examination on presentation, work-up and final diagnoses were collected. RESULTS: The total number of patients with uveitis seen over this period was 1165. There were 650 males (56%) and 515 females (44%)...
November 30, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27899225/humoral-and-cellular-response-after-varicella-vaccination-in-vzv-igg-seronegative-kidney-transplant-candidates
#19
Marcia M L Kho, Joke M Zuijderwijk, Annemiek A van der Eijk, Ronella de Kuiper, Marieken J Boer-Verschragen, Willem Weimar, Nicole M van Besouw
BACKGROUND: In immunocompromised patients, primary infection with VZV may have a disastrous clinical course. Vaccination of VZV-seronegative patients on the waiting list for renal transplantation may prevent severe disease. However, the immunologic response of end-stage renal disease patients to peptide vaccines is far from optimal. Our question was whether end-stage renal disease patients with undetectable VZV-IgG levels were able to mount an adequate humoral and cellular response to a live attenuated varicella vaccine...
January 3, 2017: Vaccine
https://www.readbyqxmd.com/read/27896415/predicting-risk-factors-for-varicella-zoster-virus-infection-and-postherpetic-neuralgia-after-hematopoietic-cell-transplantation-using-ordered-logistic-regression-analysis
#20
Yuko Kanbayashi, Yosuke Matsumoto, Junya Kuroda, Tsutomu Kobayashi, Shigeo Horiike, Toyoshi Hosokawa, Masafumi Taniwaki
To identify risk factors for varicella zoster virus (VZV) infection and postherpetic neuralgia (PHN) after hematopoietic cell transplantation (HCT), we conducted a retrospective chart review of 163 consecutive patients who underwent HCT between November 2004 and July 2014. Overall, the male/female (M/F) ratio was 80/83, median age at HCT was 54 (range 15-69) years, and autologous/allogeneic HCT (auto/allo-HCT) ratio was 71/92. Forty-four patients [M/F, 25/19; median age, 57 (range: 16-68) years; auto/allo-HCT, 26/18] developed VZV infection after HCT...
November 28, 2016: Annals of Hematology
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