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https://www.readbyqxmd.com/read/27872765/cardiac-arrest-after-local-anaesthetic-toxicity-in-a-paediatric-patient
#1
Liana Maria Torres de Araújo Azi, Diego Grimaldi Figueroa, Ana Amélia Souza Simas
We report a case of a paediatric patient undergoing urological procedure in which a possible inadvertent intravascular or intraosseous injection of bupivacaine with adrenaline in usual doses caused subsequent cardiac arrest, completely reversed after administration of 20% intravenous lipid emulsion. Early diagnosis of local anaesthetics toxicity and adequate cardiovascular resuscitation manoeuvres contribute to the favourable outcome.
2016: Case Reports in Anesthesiology
https://www.readbyqxmd.com/read/27849972/332-effect-of-timing-of-adrenaline-in-out-of-hospital-cardiac-arrest-patients
#2
Mohammed Alshahrani, Mohammed Abdulaziz Almulhim, Mohammed Abdullah Alrubaish, Talal Majed Almutairi, Laila Bidah Alqahtani, Mariam Ahmed Alhammadi, Mariam Hussain Alsulaiman, Ahmed Abdulhadi
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27650864/pre-hospital-assessment-of-the-role-of-adrenaline-measuring-the-effectiveness-of-drug-administration-in-cardiac-arrest-paramedic-2-trial-protocol
#3
Gavin D Perkins, Tom Quinn, Charles D Deakin, Jerry P Nolan, Ranjit Lall, Anne-Marie Slowther, Matthew Cooke, Sarah E Lamb, Stavros Petrou, Felix Achana, Judith Finn, Ian G Jacobs, Andrew Carson, Mike Smyth, Kyee Han, Sonia Byers, Nigel Rees, Richard Whitfield, Fionna Moore, Rachael Fothergill, Nigel Stallard, John Long, Susie Hennings, Jessica Horton, Charlotte Kaye, Simon Gates
Despite its use since the 1960s, the safety or effectiveness of adrenaline as a treatment for cardiac arrest has never been comprehensively evaluated in a clinical trial. Although most studies have found that adrenaline increases the chance of return of spontaneous circulation for short periods, many studies found harmful effects on the brain and raise concern that adrenaline may reduce overall survival and/or good neurological outcome. The PARAMEDIC-2 trial seeks to determine if adrenaline is safe and effective in out-of-hospital cardiac arrest...
November 2016: Resuscitation
https://www.readbyqxmd.com/read/27533062/drug-therapy-in-cardiac-arrest-a-review-of-the-literature
#4
REVIEW
Andreas Lundin, Therese Djärv, Johan Engdahl, Jacob Hollenberg, Per Nordberg, Annika Ravn-Fischer, Mattias Ringh, Susanne Rysz, Leif Svensson, Johan Herlitz, Peter Lundgren
The aim of this study was to review the literature on human studies of drug therapy in cardiac arrest during the last 25 years. In May 2015, a systematic literature search was performed in PubMed, Embase, the Cochrane Library, and CRD databases. Prospective interventional and observational studies evaluating a specified drug therapy in human cardiac arrest reporting a clinical endpoint [i.e. return of spontaneous circulation (ROSC) or survival] and published in English 1990 or later were included, whereas animal studies, case series and reports, studies of drug administration, drug pharmacology, non-specified drug therapies, preventive drug therapy, drug administration after ROSC, studies with primarily physiological endpoints, and studies of traumatic cardiac arrest were excluded...
January 2016: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/27522216/evidence-on-adrenaline-use-in-resuscitation-and-its-relevance-to-newborn-infants-a-non-systematic-review
#5
Merlin Pinto, Anne Lee Solevåg, Megan OʼReilly, Khalid Aziz, Po-Yin Cheung, Georg M Schmölzer
AIM: Guidelines for newborn resuscitation state that if the heart rate does not increase despite adequate ventilation and chest compressions, adrenaline administration should be considered. However, controversy exists around the safety and effectiveness of adrenaline in newborn resuscitation. The aim of this review was to summarise a selection of the current knowledge about adrenaline during resuscitation and evaluate its relevance to newborn infants. METHODS: A search in PubMed, Embase, and Google Scholar until September 1, 2015, using search terms including adrenaline/epinephrine, cardiopulmonary resuscitation, death, severe brain injury, necrotizing enterocolitis, bronchopulmonary dysplasia, and adrenaline versus vasopressin/placebo...
August 13, 2016: Neonatology
https://www.readbyqxmd.com/read/27405926/the-cpr-outcomes-of-online-medical-video-instruction-versus-on-scene-medical-instruction-using-simulated-cardiac-arrest-stations
#6
Chaiyaporn Yuksen, Sorravit Sawatmongkornkul, Jarupol Tuangsirisup, Kittisak Sawanyawisuth, Yuwares Sittichanbuncha
BACKGROUND: Non-traumatic cardiac arrest is a fatal emergency condition. Its survival rate and outcomes may be better with quick and effective cardiopulmonary resuscitation (CPR). Telemedicine such as telephone or real time video has been shown to improve chest compression procedures. There are limited data on the effects of telemedicine in cardiac arrest situations in the literature particularly in Asian settings. METHODS: This study was conducted by using two simulated cardiac arrest stations during the 2014 annual Thai national conference in emergency medicine...
July 12, 2016: BMC Emergency Medicine
https://www.readbyqxmd.com/read/27374027/current-real-life-use-of-vasopressors-and-inotropes-in-cardiogenic-shock-adrenaline-use-is-associated-with-excess-organ-injury-and-mortality
#7
Tuukka Tarvasmäki, Johan Lassus, Marjut Varpula, Alessandro Sionis, Reijo Sund, Lars Køber, Jindrich Spinar, John Parissis, Marek Banaszewski, Jose Silva Cardoso, Valentina Carubelli, Salvatore Di Somma, Alexandre Mebazaa, Veli-Pekka Harjola
BACKGROUND: Vasopressors and inotropes remain a cornerstone in stabilization of the severely impaired hemodynamics and cardiac output in cardiogenic shock (CS). The aim of this study was to analyze current real-life use of these medications, and their impact on outcome and on changes in cardiac and renal biomarkers over time in CS. METHODS: The multinational CardShock study prospectively enrolled 219 patients with CS. The use of vasopressors and inotropes was analyzed in relation to the primary outcome, i...
July 4, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27296956/sex-differences-in-the-prehospital-management-of-out-of-hospital-cardiac-arrest
#8
Bryn E Mumma, Temur Umarov
BACKGROUND: Sex differences exist in the diagnosis and treatment of several cardiovascular diseases. Our objective was to determine whether sex differences exist in the use of guideline-recommended treatments in out-of-hospital cardiac arrest (OHCA). METHODS: We included adult patients with non-traumatic OHCA treated by emergency medical services (EMS) in the Resuscitation Outcomes Consortium Prehospital Resuscitation using an IMpedance valve and Early versus Delayed (ROC PRIMED) database during 2007-2009...
August 2016: Resuscitation
https://www.readbyqxmd.com/read/27239609/assessment-of-prehospital-medical-care-for-the-patients-transported-to-emergency-department-by-ambulance
#9
Sehnaz Akın Paker, Seda Dagar, Erkan Gunay, Zeynep Temizyurek Cebeci, Ersin Aksay
OBJECTIVES: In our study we aimed to investigate the quality and quantity of medical management inside ambulances for 14 and over 14 years old patients transported to a level three emergency department (ED). MATERIAL AND METHODS: Our study was conducted prospectively at a level three ED. 14 and over 14 years old patients who were transported to the ED by ambulance were included in the study consecutively. "Lack of vital rate" was described as missing of one or more of five vital rates during ambulance transportation...
September 2015: Turk J Emerg Med
https://www.readbyqxmd.com/read/27100952/circulatory-collapse-following-epidural-bolus-for-caesarean-section-a-profound-vasovagal-reaction-a-case-report
#10
Eva Oddby, Anette Hein, Jan G Jakobsson
INTRODUCTION: Reduced blood pressure is commonly seen associated to spinal anaesthesia for Caesarean section and efforts to reduce its occurrence and its magnitude is common practice. Cardiovascular collapse requiring cardio-pulmonary resuscitation after putting the spinal/epidural block for Caesarean section is however a rare but most dramatic event. PRESENTATION OF CASE: We describe a case with sudden short loss of circulation, circulatory collapse, short after start of emergency Caesarean section in top up epidural anaesthesia (3+12ml ropivaciane 7...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27099380/bet-2-usefulness-of-epinephrine-in-out-of-hospital-cardiac-arrest
#11
Megan E Evans, Todd Chassee
A short-cut review was carried out to establish whether prehospital adrenaline affects long-term morbidity or mortality after out-of-hospital cardiac arrest. Fifty-five papers were found using the reported search. Of these, three presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these best papers are tabulated. It is concluded that while epinephrine used as an adjunctive treatment during out-of-hospital cardiac arrest (OHCA) may improve return of spontaneous circulation (ROSC) and survival to hospital, it does not improve survival to discharge or neurological outcome...
May 2016: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/27095125/monitoring-of-brain-oxygenation-during-hypothermic-cpr-a-prospective-porcine-study
#12
Gabriel Putzer, Patrick Braun, Giacomo Strapazzon, Martha Toferer, Miriam Mulino, Bernhard Glodny, Markus Falk, Hermann Brugger, Peter Paal, Raimund Helbok, Peter Mair
BACKGROUND AND AIM: Limited data are available concerning the impact of CPR interventions on cerebral oxygenation during hypothermic cardiac arrest. We therefore studied cerebral perfusion pressure (CPP), brain tissue oxygen tension (PbtO2), cerebral venous oxygen saturation (ScvO2) and regional cerebral oxygen saturation (rSO2) in an animal model of hypothermic CPR. We also assessed the correlation between rSO2 and CPP, PbtO2 and ScvO2 to clarify whether near-infrared spectroscopy (NIRS) may be used to non-invasively monitor changes in cerebral oxygenation during hypothermic CPR...
July 2016: Resuscitation
https://www.readbyqxmd.com/read/27080141/arterial-pressure-end-tidal-carbon-dioxide-and-central-venous-oxygen-saturation-in-reflecting-compression-depth
#13
COMMENT
S-J Ryu, S-J Lee, C-H Park, S-M Lee, D-H Lee, Y-S Cho, Y-H Jung, B-K Lee, K-W Jeung
BACKGROUND: We sought to investigate the utility of arterial pressure, end-tidal carbon dioxide (ETCO2 ), and central venous oxygen saturation (SCVO2 ) to guide compression depth adjustment. Thus, in a pig model of cardiac arrest, we observed these parameters during cardiopulmonary resuscitation (CPR) with optimal and suboptimal compression depths. METHODS: Sixteen pigs underwent three experimental sessions after induction of ventricular fibrillation. First, the animals received two 4-min CPR trials with either optimal (20% of the anteroposterior diameter) or suboptimal (70% of the optimal depth) compression depth...
August 2016: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/27053638/early-administration-of-epinephrine-adrenaline-in-patients-with-cardiac-arrest-with-initial-shockable-rhythm-in-hospital-propensity-score-matched-analysis
#14
MULTICENTER STUDY
Lars W Andersen, Tobias Kurth, Maureen Chase, Katherine M Berg, Michael N Cocchi, Clifton Callaway, Michael W Donnino
OBJECTIVES: To evaluate whether patients who experience cardiac arrest in hospital receive epinephrine (adrenaline) within the two minutes after the first defibrillation (contrary to American Heart Association guidelines) and to evaluate the association between early administration of epinephrine and outcomes in this population. DESIGN: Prospective observational cohort study. SETTING: Analysis of data from the Get With The Guidelines-Resuscitation registry, which includes data from more than 300 hospitals in the United States...
2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27017777/-a-case-of-cardiac-arrest-following-intra-articular-administration-of-levobupivacaine-during-total-knee-arthroplasty
#15
Asami Tomita, Makoto Satani, Keitaro Suzuki, Arito Kaji, Shinji Urushitani
A 73-year-old woman with normal cardiac function underwent an elective total knee arthroplasty. After skin closure, levobupivacaine 225 mg was injected into the knee and 25 mg was injected subcutaneously. The patient recovered from general anesthesia 5 min after the surgery. Thirty five min after surgery, while in general radiology department her carotid arterial pulses were not palpable. Cardiopulmonary resuscitation (CPR) was initiated with intravenous (i.v.) administration of adrenaline 1 mg. Circulation was rapidly restored...
February 2016: Masui. the Japanese Journal of Anesthesiology
https://www.readbyqxmd.com/read/26841960/-which-drugs-are-useful-during-resuscitation-which-are-not
#16
Wilhelm Haverkamp
INTRODUCTION: Cardiopulmonary resuscitation represents a therapeutic challenge. Evidence-based guidelines, which were updated in 2015, give detailed advice on how to treat the patient. METHODS: Basic life support consists of cardiopulmonary resuscitation (30 chest compressions interrupted briefly to provide to 2 ventilations) and, if ventricular tachyarrhythmia is present, urgent cardiac defibrillation. Administration of drugs is one of the aspects of advanced life support...
March 2016: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/26819708/rationale-design-and-profile-of-comprehensive-registry-of-in-hospital-intensive-care-for-ohca-survival-critical-study-in-osaka-japan
#17
Tomoki Yamada, Tetsuhisa Kitamura, Koichi Hayakawa, Kazuhisa Yoshiya, Taro Irisawa, Yoshio Abe, Megumi Ishiro, Toshifumi Uejima, Yasuo Ohishi, Kazuhisa Kaneda, Takeyuki Kiguchi, Masashi Kishi, Masafumi Kishimoto, Shota Nakao, Tetsuro Nishimura, Yasuyuki Hayashi, Takaya Morooka, Junichi Izawa, Tomonari Shimamoto, Toshihiro Hatakeyama, Tasuku Matsuyama, Takashi Kawamura, Takeshi Shimazu, Taku Iwami
BACKGROUND: We established a multi-center, prospective cohort that could provide appropriate therapeutic strategies such as criteria for the introduction and the effectiveness of in-hospital advanced treatments, including percutaneous coronary intervention (PCI), target temperature management, and extracorporeal cardiopulmonary resuscitation (ECPR) for out-of-hospital cardiac arrest (OHCA) patients. METHODS: In Osaka Prefecture, Japan, we registered all consecutive patients who were suffering from an OHCA for whom resuscitation was attempted and who were then transported to institutions participating in this registry since July 1, 2012...
2016: Journal of Intensive Care
https://www.readbyqxmd.com/read/26689353/cardiorespiratory-arrest-in-children-out-of-hospital
#18
Kristina Krmpotic, Hilary Writer
INTRODUCTION: Cardiorespiratory arrest outside hospital occurs in approximately 1/10,000 children per year in resource-rich countries, with two-thirds of arrests occurring in children under 18 months of age. Approximately 45% of cases have undetermined causes, including sudden infant death syndrome. Of the rest, 20% are caused by trauma, 10% by chronic disease, and 6% by pneumonia. METHODS AND OUTCOMES: We conducted a systematic overview, aiming to answer the following clinical question: What are the effects of treatments for non-submersion out-of-hospital cardiorespiratory arrest in children? We searched: Medline, Embase, The Cochrane Library, and other important databases up to November 2014 (Clinical Evidence overviews are updated periodically; please check our website for the most up-to-date version of this overview)...
2015: Clinical Evidence
https://www.readbyqxmd.com/read/26307453/the-time-dependent-association-of-adrenaline-administration-and-survival-from-out-of-hospital-cardiac-arrest
#19
MULTICENTER STUDY
Gordon A Ewy, Bentley J Bobrow, Vatsal Chikani, Arthur B Sanders, Charles W Otto, Daniel W Spaite, Karl B Kern
BACKGROUND: Recommended for decades, the therapeutic value of adrenaline (epinephrine) in the resuscitation of patients with out-of-hospital cardiac arrest (OHCA) is controversial. PURPOSE: To investigate the possible time-dependent outcomes associated with adrenaline administration by Emergency Medical Services personnel (EMS). METHODS: A retrospective analysis of prospectively collected data from a near statewide cardiac resuscitation database between 1 January 2005 and 30 November 2013...
November 2015: Resuscitation
https://www.readbyqxmd.com/read/26257014/kounis-syndrome-with-samter-beer-triad-treated-with-intracoronary-adrenaline
#20
Abdul Rahman Ihdayhid, Jamie Rankin
Kounis syndrome is a well-described clinical condition characterized by the simultaneous occurrence of chest pain and an allergic reaction accompanied by clinical and laboratory findings of angina caused by inflammatory mediators released during an allergic insult. We present the case of a 50-year-old male with the Samter-Beer triad of asthma, nasal polyps, and salicylate intolerance with an ST elevation myocardial infarction complicated with cardiac arrest due to multi-vessel coronary artery spasm secondary to aspirin anaphylaxis...
November 15, 2015: Catheterization and Cardiovascular Interventions
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