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https://www.readbyqxmd.com/read/28231043/transient-oxytocin-signaling-primes-the-development-and-function-of-excitatory-hippocampal-neurons
#1
Silvia Ripamonti, Mateusz C Ambrozkiewicz, Francesca Guzzi, Marta Gravati, Gerardo Biella, Ingo Bormuth, Matthieu Hammer, Liam P Tuffy, Albrecht Sigler, Hiroshi Kawabe, Katsuhiko Nishimori, Mauro Toselli, Nils Brose, Marco Parenti, JeongSeop Rhee
Beyond its role in parturition and lactation, oxytocin influences higher brain processes that control social behavior of mammals, and perturbed oxytocin signaling has been linked to the pathogenesis of several psychiatric disorders. However, it is still largely unknown how oxytocin exactly regulates neuronal function. We show that early, transient oxytocin exposure in vitro inhibits the development of hippocampal glutamatergic neurons, leading to reduced dendrite complexity, synapse density, and excitatory transmission, while sparing GABAergic neurons...
February 23, 2017: ELife
https://www.readbyqxmd.com/read/28227903/development-of-a-detailed-model-of-calcium-dynamics-at-the-postsynaptic-spine-of-an-excitatory-synapse
#2
Eric Y Hu, Jean-Marie C Bouteiller, Dong Song, Theodore W Berger, Eric Y Hu, Jean-Marie C Bouteiller, Dong Song, Theodore W Berger, Jean-Marie C Bouteiller, Eric Y Hu, Dong Song, Theodore W Berger
Postsynaptic calcium dynamics play a critical role in synaptic plasticity, but are often difficult to measure in experimental protocols due to their relatively fast rise and decay times, and the small spine dimensions. To circumvent these limitations, we propose to develop a computational model of calcium dynamics in the postsynaptic spine. This model integrates the main elements that participate in calcium concentration influx, efflux, diffusion and buffering. These consist of (i) spine geometry; (ii) calcium influx through NMDA receptors and voltage-dependent calcium channels (VDCC); (iii) calcium efflux with plasma membrane calcium pumps (PMCA) and sodium-calcium exchangers (NCX); (iv) intracellular calcium stores; and (v) calcium buffers...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227179/influence-of-electrode-configuration-on-the-electric-field-distribution-during-transcutaneous-spinal-direct-current-stimulation-of-the-cervical-spine
#3
Sofia R Fernandes, Ricardo Salvador, Cornelia Wenger, Mamede A de Carvalho, Pedro C Miranda, Sofia R Fernandes, Ricardo Salvador, Cornelia Wenger, Mamede A de Carvalho, Pedro C Miranda, Sofia R Fernandes, Pedro C Miranda, Cornelia Wenger, Ricardo Salvador, Mamede A de Carvalho
Transcutaneous spinal direct current stimulation (tsDCS) is a recent technique with promising neuromodulatory effects on spinal neuronal circuitry. The main objective of the present study was to perform a finite element analysis of the electric field distribution in tsDCS in the cervical spine region, with varying electrode configurations and geometry. A computational model of a human trunk was generated with nine tissue meshes. Three electrode configurations were tested: A) rectangular saline-soaked sponge target and return electrodes placed over C3 and T3 spinous processes, respectively; B1) circular saline-soaked sponge target and return electrodes placed over C7 spinous process and right deltoid muscle, respectively; B2) same configuration as B1, considering circular shaped electrodes with sponge and rubber layers and a small circular connector on the top surface...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226850/the-effect-of-inter-electrode-distance-on-the-electric-field-distribution-during-transcutaneous-lumbar-spinal-cord-direct-current-stimulation
#4
Rui Bastos, Sofia R Fernandes, Ricardo Salvador, Cornelia Wenger, Mamede A de Carvalho, Pedro C Miranda, Rui Bastos, Sofia R Fernandes, Ricardo Salvador, Cornelia Wenger, Mamede A de Carvalho, Pedro C Miranda, Pedro C Miranda, Rui Bastos, Cornelia Wenger, Ricardo Salvador, Mamede A de Carvalho, Sofia R Fernandes
Previous studies have indicated potential neuromodulation of the spinal circuitry by transcutaneous spinal direct current stimulation (tsDCS), such as changes in motor unit recruitment, shortening of the peripheral silent period and interference with supraspinal input to lower motor neurons. All of these effects were dependent on the polarity of the electrodes. The present study investigates how the distance between the electrodes during tsDCS influences the electric field's (E-field) spatial distribution in the lumbar and sacral spinal cord (SC)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226581/automatic-lumbar-vertebrae-detection-based-on-feature-fusion-deep-learning-for-partial-occluded-c-arm-x-ray-images
#5
Yang Li, Wei Liang, Yinlong Zhang, Haibo An, Jindong Tan, Yang Li, Wei Liang, Yinlong Zhang, Haibo An, Jindong Tan, Yang Li, Wei Liang, Jindong Tan, Yinlong Zhang, Haibo An
Automatic and accurate lumbar vertebrae detection is an essential step of image-guided minimally invasive spine surgery (IG-MISS). However, traditional methods still require human intervention due to the similarity of vertebrae, abnormal pathological conditions and uncertain imaging angle. In this paper, we present a novel convolutional neural network (CNN) model to automatically detect lumbar vertebrae for C-arm X-ray images. Training data is augmented by DRR and automatic segmentation of ROI is able to reduce the computational complexity...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225365/magnitude-location-and-factors-related-to-regional-and-global-sagittal-alignment-change-in-long-adult-deformity-constructs-report-of-183-patients-with-2-year-follow-up
#6
Alexander A Theologis, Michael Safaee, Justin K Scheer, Virginie Lafage, Rick Hostin, Robert A Hart, Eric O Klineberg, Themistocles S Protopsaltis, Vedat Deviren, Douglas C Burton, Daniel M Sciubba, Khaled Kebaish, Shay Bess, Christopher I Shaffrey, Frank Schwab, Justin S Smith, Christopher P Ames
STUDY DESIGN: This is a retrospective review of a prospective multicenter adult spinal deformity (ASD) database. OBJECTIVE: To quantify the location and magnitude of sagittal alignment changes within instrumented and noninstrumented spinal segments and to investigate the factors associated with these changes after surgery for ASD. SUMMARY OF BACKGROUND DATA: Spinal realignment is one of the major goals in ASD surgery and changes in the alignment are common following surgical correction...
February 20, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28225309/anabolic-bone-window-with-weekly-teriparatide-therapy-in-post-menopausal-osteoporosis-a-pilot-study
#7
Vinaya Gopalaswamy, Deba Prasad Dhibar, Vipin Gupta, Ashutosh Kumar Arya, Niranjan Khandelwal, Anil Bhansali, Sudhir Kumar Garg, Neelam Agarwal, Sudhaker D Rao, Sanjay Kumar Bhadada
BACKGROUND: Osteoporosis is a major public health problem, which reduces bone strength and increases risk of fracture. Teriparatide is an established and the only currently available anabolic therapy for the treatment of postmenopausal osteoporosis (PMO) with recommended daily dose of 20 μg subcutaneously. However data regarding the long term effect of once-weekly teriparatide therapy on bone mineral density (BMD), bone turnover markers (BTMs) and anabolic bone window is limited. METHODS: In this prospective observational study, 26 patients with PMO were treated with weekly teriparatide therapy (60 μg) for 2 years...
February 22, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28224639/rigid-spine-syndrome-associated-with-sensory-motor-axonal-neuropathy-resembling-charcot-marie-tooth-disease-is-characteristic-of-bag3-gene-mutations-even-without-cardiac-involvement
#8
Jean-Baptiste Noury, Thierry Maisonobe, Pascale Richard, Valérie Delague, Edoardo Malfatti, Tanya Stojkovic
INTRODUCTION: BAG3 (Bcl-2 associated athanogene-3) mutations have been described in rare cases of rapidly progressive myofibrillar myopathies. Symptoms begin in the first decade with axial involvement and contractures and are associated with cardiac and respiratory impairment in the second decade. Axonal neuropathy has been documented, but usually not as a key clinical feature. METHODS: We report a 24-year-old woman with severe rigid spine syndrome and sensory-motor neuropathy resembling Charcot-Marie-Tooth disease (CMT)...
February 22, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28220607/neurological-and-spinal-manifestations-of-the-ehlers-danlos-syndromes
#9
Fraser C Henderson, Claudiu Austin, Edward Benzel, Paolo Bolognese, Richard Ellenbogen, Clair A Francomano, Candace Ireton, Petra Klinge, Myles Koby, Donlin Long, Sunil Patel, Eric L Singman, Nicol C Voermans
The Ehlers-Danlos syndromes (EDS) are a heterogeneous group of heritable connective tissue disorders characterized by joint hypermobility, skin extensibility, and tissue fragility. This communication briefly reports upon the neurological manifestations that arise including the weakness of the ligaments of the craniocervical junction and spine, early disc degeneration, and the weakness of the epineurium and perineurium surrounding peripheral nerves. Entrapment, deformation, and biophysical deformative stresses exerted upon the nervous system may alter gene expression, neuronal function and phenotypic expression...
February 21, 2017: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
https://www.readbyqxmd.com/read/28220061/a-model-of-induction-of-cerebellar-long-term-depression-including-rkip-inactivation-of-raf-and-mek
#10
Iain Hepburn, Anant Jain, Himanshu Gangal, Yukio Yamamoto, Keiko Tanaka-Yamamoto, Erik De Schutter
We report an updated stochastic model of cerebellar Long Term Depression (LTD) with improved realism. Firstly, we verify experimentally that dissociation of Raf kinase inhibitor protein (RKIP) from Mitogen-activated protein kinase kinase (MEK) is required for cerebellar LTD and add this interaction to an earlier published model, along with the known requirement of dissociation of RKIP from Raf kinase. We update Ca(2+) dynamics as a constant-rate influx, which captures experimental input profiles accurately...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28217398/comparison-of-intubation-success-and-glottic-visualization-using-king-vision-and-c-mac-videolaryngoscopes-in-patients-with-cervical-spine-injuries-with-cervical-immobilization-a-randomized-clinical-trial
#11
Dhanyasi Shravanalakshmi, Prasanna U Bidkar, K Narmadalakshmi, Suman Lata, Sandeep K Mishra, S Adinarayanan
BACKGROUND: Glottic visualization can be difficult with cervical immobilization in patients with cervical spine injury. Indirect laryngoscopes may provide better glottic visualization in these groups of patients. Hence, we compared King Vision videolaryngoscope, C-MAC videolaryngoscope for endotracheal intubation in patients with proven/suspected cervical spine injury. METHODS: After standard induction of anesthesia, 135 patients were randomized into three groups: group C (conventional C-MAC videolaryngoscope), group K (King Vision videolaryngoscope), and group D (D blade C-MAC videolaryngoscope)...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28214618/deep-neck-flexor-endurance-in-the-adolescent-and-young-adult-normative-data-and-associated-attributes
#12
Nathan F Jarman, Toby Brooks, C Roger James, Troy Hooper, Mark Wilhelm, Jean-Michel Brismée, Manuel A Domenech, Stanley J Kotara, Phillip S Sizer
BACKGROUND: Deep neck flexor (DNF) muscles stabilize the neck and contribute to head acceleration control. The function of DNF in cervical spine dynamic stabilization has not been examined in athletes of any age group, including adolescents. This investigation was necessary prior to studying the DNF muscles' role in cervical spine injury patterns. OBJECTIVES: (1) To determine average Deep Neck Flexor Endurance Test (DNFET) time scores in high school and university-aged subjects (ages 14-22); and (2) To establish the relationship between gender and age for adolescent DNFET time scores...
February 15, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28212898/low-serum-iron-is-associated-with-high-serum-intact-fgf23-in-elderly-men-the-swedish-mros-study
#13
Catharina Lewerin, Östen Ljunggren, Herman Nilsson-Ehle, Magnus K Karlsson, Hans Herlitz, Mattias Lorentzon, Claes Ohlsson, Dan Mellström
BACKGROUND: Fibroblast growth factor (FGF23) is a protein that is produced by osteoblasts and osteocytes. Increased serum levels of FGF23 have been associated with increased risks of osteoporotic fractures and cardiovascular disease, particularly in participants with poor renal function. Serum iron (Fe) has been suggested as a regulator of FGF23 homeostasis. OBJECTIVE: To determine whether Fe and iron status are determinants of the levels of intact FGF23 (iFGF23) in elderly men...
February 14, 2017: Bone
https://www.readbyqxmd.com/read/28211588/is-this-back-pain-killing-me-all-cause-and-cardiovascular-specific-mortality-in-older-danish-twins-with-spinal-pain
#14
M Fernandez, E Boyle, J Hartvigsen, M L Ferreira, K M Refshauge, C G Maher, K Christensen, J L Hopper, P H Ferreira
BACKGROUND: Few studies have examined the potentially reduced life expectancy associated with spinal pain (i.e. low back and neck pain) in an ageing population, particularly after controlling for familial factors, including genetics. METHODS: We investigated whether spinal pain increased the rate of all-cause and disease-specific cardiovascular mortality in older Danish twins aged ≥70 years. Data from 4391 participants collected at baseline were linked with the Danish Cause of Death Registry with the study ending on 31 December 2014...
February 17, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28211302/is-c1-lateral-mass-screw-placement-safe-for-the-chinese-indians-and-malays-an-analysis-of-180-computed-tomography-scans
#15
C K Lee, T S Tan, Cyw Chan, M K Kwan
INTRODUCTION: C1 lateral mass (C1LM) screw is a common procedure in spine surgery. However, related studies are lacking in Asia. We aim to determine the safety of C1LM screw for the Chinese, Indians, and Malays. METHODS: Three-dimensional computed tomographies of 180 subjects (60 from each ethnic) were analyzed. The length and angulations of C1LM screw and the location of internal carotid artery (ICA) in relation to C1LM were assessed and classified according to the classification by Murakami et al...
January 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28208954/effect-of-surgical-curve-correction-on-exercise-tolerance-and-physical-capacities-in-patients-of-severe-spinal-deformity
#16
Prateek C Patil, Ashok K Rathod, Mandar Borde, Vishwajeet Singh, Hemant U Singh
INTRODUCTION: Traditionally, surgical intervention for patients with a spinal deformity has been considered for cosmetic benefits, but surgical intervention can alter the lung physiology or volumes and in turn leads to increase in physical capacity and exercise tolerance. Therefore, we conducted this to determine whether a surgical correction would restore the lung physiology, physical capacity and exercise tolerance in patients with kyphoscoliosis. AIM: To evaluate the usage of six-minute walk test scores and modified Borg scores as tools/measures for exercise tolerance in patients with spinal deformity and to study the effects of surgical correction of spinal deformity on exercise tolerance with above parameters as the measures...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208457/critical-phenomena-on-k-booklets
#17
Peter Grassberger
We define a "k-booklet" to be a set of k semi-infinite planes with -∞<x<∞ and y≥0, glued together at the edges (the "spine") y=0. On such booklets we study three critical phenomena: self-avoiding random walks, the Ising model, and percolation. For k=2, a booklet is equivalent to a single infinite lattice, and for k=1 to a semi-infinite lattice. In both these cases the systems show standard critical phenomena. This is not so for k≥3. Self-avoiding walks starting at y=0 show a first-order transition at a shifted critical point, with no power-behaved scaling laws...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28207623/feasibility-of-percutaneous-posterolateral-spinal-fusion-with-recombinant-bone-morphogenetic-protein-2-rhbmp-2-a-comparison-with-standard-methods-using-an-animal-model-study
#18
Chris Yin Wei Chan, Mun Keong Kwan, Lim Beng Saw, Hussin Paisal
BACKGROUND CONTEXT: The clinical application of recombinant bone morphogenetic protein in spinal surgery has been shown to be safe and effective. However, its use in minimally invasive spine surgery has been limited to anterior interbody fusion procedures. To date, no study has evaluated the feasibility of percutaneous posterolateral fusion in the spine utilizing recombinant bone morphogenetic protein-2 (rhBMP-2). PURPOSE: To evaluate the feasibility of percutaneous posterolateral fusion in the spine utilizing rhBMP-2...
March 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28204927/bicortical-facet-screws-as-a-new-option-for-posterior-c2-fixation-anatomical-study-and-clinical-experience
#19
Angelo Rusconi, E Freitas-Olim, P Coloma, R Messerer, C Barrey
PURPOSE: C2 fixation is a demanding procedure, particularly in patients with variants of C1-C2 anatomy. The inferior articular process (IAP) of the axis can be an alternative for screw placement. We report the results of a CT study of C2 IAP anatomy and we present the clinical experience of 28 patients operated with this technique. METHODS: Anatomical study: 50 CT angiographies of the vertebral arteries (VA) were used for this study and, therefore, 100 IAPs were considered...
February 15, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28203735/intraoperative-tranexamic-acid-use-in-major-spine-surgery-in-adults-a-multicentre-randomized-placebo-controlled-trial%C3%A2
#20
M J Colomina, M Koo, M Basora, J Pizones, L Mora, J Bagó
No abstract text is available yet for this article.
March 1, 2017: British Journal of Anaesthesia
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