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https://www.readbyqxmd.com/read/29786777/the-biomechanics-of-the-inter-lamellar-matrix-and-the-lamellae-during-progression-to-lumbar-disc-herniation-which-is-the-weakest-structure
#1
Javad Tavakoli, Dhara B Amin, Brian J C Freeman, John J Costi
While microstructural observations have improved our understanding of possible pathways of herniation progression, no studies have measured the mechanical failure properties of the inter-lamellar matrix (ILM), nor of the adjacent lamellae during progression to herniation. The aim of this study was to employ multiscale, biomechanical and microstructural techniques to evaluate the effects of progressive induced herniation on the ILM and lamellae in control, pre-herniated and herniated discs (N = 7), using 2 year-old ovine spines...
May 21, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29786529/corrigendum-to-adverse-events-associated-with-the-use-of-cervical-spine-manipulation-or-mobilization-and-patient-characteristics-a-systematic-review-musculoskelet-sci-pract-28c-2017-32-38
#2
H A Kranenburg, M A Schmitt, E J Puentedura, G J Luijckx, C P van der Schans
No abstract text is available yet for this article.
May 18, 2018: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/29786422/mechanisms-regulating-the-association-of-protein-phosphatase-1-with-spinophilin-and-neurabin
#3
Michael C Edler, Asma B Salek, Darryl S Watkins, Harjot Kaur, Cameron W Morris, Bryan K Yamamoto, Anthony J Baucum
Protein phosphorylation is a key mediator of signal transduction, allowing for dynamic regulation of substrate activity. Whereas protein kinases obtain substrate specificity by targeting specific amino acid sequences, serine/threonine phosphatase catalytic subunits are much more promiscuous in their ability to dephosphorylate substrates. To obtain substrate specificity, serine/threonine phosphatases utilize targeting proteins to regulate phosphatase subcellular localization and catalytic activity. Spinophilin and its homolog neurabin are two of the most abundant dendritic spine-localized protein phosphatase 1 (PP1) targeting proteins...
May 22, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29784826/deletion-of-lrrtm1-and-lrrtm2-in-adult-mice-impairs-basal-ampa-receptor-transmission-and-ltp-in-hippocampal-ca1-pyramidal-neurons
#4
Mehdi Bhouri, Wade Morishita, Paul Temkin, Debanjan Goswami, Hiroshi Kawabe, Nils Brose, Thomas C Südhof, Ann Marie Craig, Tabrez J Siddiqui, Robert Malenka
Leucine-rich repeat transmembrane (LRRTM) proteins are synaptic cell adhesion molecules that influence synapse formation and function. They are genetically associated with neuropsychiatric disorders, and via their synaptic actions likely regulate the establishment and function of neural circuits in the mammalian brain. Here, we take advantage of the generation of a LRRTM1 and LRRTM2 double conditional knockout mouse ( LRRTM1,2 cKO) to examine the role of LRRTM1,2 at mature excitatory synapses in hippocampal CA1 pyramidal neurons...
May 21, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29784654/preliminary-study-into-the-skeletal-injuries-sustained-to-the-spine-from-posterior-non-perforating-ballistic-impacts-into-body-armour
#5
Rosalind M Jennings, C Malbon, F Brock, S E Harrisson, D J Carr
INTRODUCTION: The aim of this paper was to examine any injuries from posterior behind armour blunt trauma ballistic impacts directly over the spine onto typical hard body armours. Due to the spine being close to the surface of the skin and a lack of any previous specific research into this topic, this study was designed to gain preliminary insight into the mechanisms involved and injuries caused. Pigs were chosen as the closest representative of human spine, tissue and skin, although their spines are deeper under the surface than humans...
May 21, 2018: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/29783868/low-bone-mineral-density-in-ambulatory-persons-with-cerebral-palsy-a-systematic-review
#6
Cindy T R Mus-Peters, Bionka M A Huisstede, Suzie Noten, Minou W M G C Hitters, Wilma M A van der Slot, Rita J G van den Berg-Emons
PURPOSE: Non-ambulatory persons with cerebral palsy are prone to low bone mineral density. In ambulatory persons with cerebral palsy, bone mineral density deficits are expected to be small or absent, but a consensus conclusion is lacking. In this systematic review bone mineral density in ambulatory persons with cerebral palsy (Gross Motor Function Classification Scales I-III) was studied. MATERIALS AND METHODS: Medline, Embase, and Web of Science were searched. According to international guidelines, low bone mineral density was defined as Z-score ≤ -2...
May 22, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29783670/adult-premenopausal-bone-health-related-to-reproductive-characteristics-population-based-data-from-the-canadian-multicentre-osteoporosis-study-cam-os
#7
Azita Goshtasebi, Claudie Berger, Susan I Barr, Christopher S Kovacs, Tanveer Towheed, K Shawn Davison, Jerilynn C Prior
Amenorrhea is important for women's bone health. However, few have reported reproductive, anthropometric (body mass index [BMI], height) and bone health (areal bone mineral density [BMD], prevalent fractures) in a population-based study. The purposes of this cross-sectional study of women in the randomly-selected Canadian Multicentre Osteoporosis Study (CaM os ) population were: (1) to describe reproductive, demographic, anthropometric and lifestyle variables; and (2) in menstruating women, to relate reproductive and other variables to BMD at the lumbar spine (L1-4, LS), femoral neck (FN) and total hip (TH) sites and to prevalent fragility fractures...
May 18, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29783641/premature-spinal-bone-loss-in-women-living-with-hiv-is-associated-with-shorter-leukocyte-telomere-length
#8
Shirin Kalyan, Neora Pick, Alice Mai, Melanie C M Murray, Kristen Kidson, Jackson Chu, Arianne Y K Albert, Hélène C F Côté, Evelyn J Maan, Azita Goshtasebi, Deborah M Money, Jerilynn C Prior
With advances in combination antiretroviral therapy (cART), people living with HIV are now surviving to experience aging. Evidence suggests that individuals living with HIV are at greater risk for low bone mineral density (BMD), osteoporosis, and fractures. Better understanding of the pathophysiology of bone health in women living with HIV (WLWH) is important for treatment strategies. The goal of this study was to explore new biological factors linked to low BMD in WLWH. Standardized BMD measures of WLWH were compared to reference values from an unselected population of women from the same geographical region of the same age range...
May 18, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29783630/does-molimina-indicate-ovulation-prospective-data-in-a-hormonally-documented-single-cycle-in-spontaneously-menstruating-women
#9
Jerilynn C Prior, Chiaki Konishi, Christine L Hitchcock, Elaine Kingwell, Patti Janssen, Anthony P Cheung, Nichole Fairbrother, Azita Goshtasebi
Approximately 33% of normal-length (21⁻35 days) cycles have subclinical ovulatory disturbances and lack sufficient progesterone, although their normal length ensures enough estrogen. Subclinical ovulatory disturbances are related to significant premenopausal spine bone loss (-0.86%/year). Molimina, non-distressing premenstrual experiences, may detect ovulation within normal-length cycles. This prospective study assessed the relationship between molimina and ovulation. After 1-cycle of daily diary and first morning urine collections, women answered the Molimina Question (MQ): " Can you tell by the way you feel that your period is coming? " and were invited to share (a) predictive premenstrual experience(s)...
May 18, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29781783/clinical-and-radiological-outcome-of-non-surgical-management-of-thoracic-and-lumbar-spinal-fracture-dislocations-a-historical-analysis-in-the-era-of-modern-spinal-surgery
#10
Andrei Fernandes Joaquim, Gregory D Schroeder, Alpesh A Patel, Alexander R Vaccaro
CONTEXT: It is well established that traumatic spinal dislocations (AO Type C injuries) should be surgically treated. However, no recent comparative study of surgical versus non-surgical management of type C injuries was found attesting the superiority of surgical treatment. OBJECTIVE: Due to the lack of information about the natural history of non-surgical management of type C injuries, we evaluated the outcome of historical conservative treatment of type C injuries...
May 21, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29781552/topical-rifampin-powder-for-orthopaedic-trauma-part-i-rifampin-powder-reduces-recalcitrant-infection-in-a-delayed-treatment-musculoskeletal-trauma-model
#11
Stefanie M Shiels, David J Tennent, Joseph C Wenke
Open fractures become infected despite meticulous debridement and care. Locally applied antibiotics, commonly embedded in polymethylmethacrylate, deliver high doses of drug directly to the fracture site. Direct application of antibiotic powder, which is being applied prophylactically in spine surgery, is a recent interest in the trauma sector, where bacterial biofilms are more prevalent. Traditional antibiotics, such as vancomycin, are poor performers against bacterial biofilms thus are ineffective in delayed treatment...
May 21, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29777897/robot-assisted-radiofrequency-ablation-of-a-sacral-s1-s2-aggressive-hemangioma
#12
A Kaoudi, C Capel, L Chenin, J Peltier, M Lefranc
Aggressive vertebral hemangiomas are rare tumors of the spine. The treatment management strategy usually consists of vertebroplasty, radiation therapy or in rare cases of surgical strategy. We present a case of a bulging sacral S1-S2 hemangioma in the spinal canal that could not be managed in the usual manner. Here, we demonstrate the usefulness of radiofrequency ablation technique as an alternative treatment as well as robotic assistance for optimal placement of the ablation probe within the lesion.
May 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29775132/evaluation-of-lateral-atlantodental-interval-asymmetry-in-the-pediatric-age-group-normative-values
#13
Stephen K Mendenhall, Andrew Huh, Janit Pandya, Vincent Alentado, Karl Balsara, Chang Ho, Andrew Jea
OBJECTIVE The revelation of normative radiographic measurements for the developing pediatric spine is incomplete. The purpose of this analysis was to determine the normal range of asymmetry of the lateral atlantodental interval (LADI) and define age- and sex-related differences. METHODS A total of 3072 children aged 0-18 years who underwent CT scanning of the cervical spine were identified at Riley Hospital for Children between 2005 and 2017. Patients were stratified by sex and age (in years) into 36 cohorts...
May 18, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29774400/cost-effectiveness-of-osteoporosis-screening-strategies-for-hip-fracture-prevention-in-older-chinese-people-a-decision-tree-modeling-study-in-the-mr-os-and-ms-os-cohort-in-hong-kong
#14
Y Su, F T T Lai, B H K Yip, J C S Leung, T C Y Kwok
Despite the high costs of hip fracture, many governments provide limited support for osteoporosis screening. We demonstrated that osteoporosis screening by dual-energy X-ray absorptiometry (DXA) with or without pre-screening by Fracture Risk Assessment Tool (FRAX) or calcaneal ultrasound are more cost-effective than no screening in Chinese people aged 65 or over in Hong Kong. INTRODUCTION: To examine the cost-effective potential osteoporosis screening strategies for hip fracture prevention in Hong Kong...
May 17, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29772857/-posterior-spinal-canal-decompression-with-screw-fixation-and-reconstruction-of-three-vertebral-column-for-thoracolumbar-burst-fractures-complicated-with-nerve-injury
#15
Li-Yong Wu, Xue-Mei Huang, Yue Wang, Zhao-Bo Yang, Sheng-Hui Su, Chun Wang
OBJECTIVE: To explore the feasibility and clinical effect of posterior spinal canal decompression with pedicle screw fixation and reconstruction of anterior and middle vertebral column for thoracolumbar burst fractures complicated with nerve injury. METHODS: A total of 36 patients with thoracolumbar burst fractures treated from March 2011 to April 2016 were enrolled in the retrospective study. There were 20 males and 16 females, aged from 21 to 52 years old with an average of 37...
April 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29770804/publication-trends-in-spine-research-from-2007-to-2016-comparison-of-the-orthopaedic-research-society-spine-section-and-the-international-society-for-the-study-of-the-lumbar-spine
#16
John T Martin, Sarah E Gullbrand, Aaron J Fields, Devina Purmessur, Ashish D Diwan, Thomas R Oxland, Kazuhiro Chiba, Farshid Guilak, Judith A Hoyland, James C Iatridis
This study investigated current trends in spine publications of the membership of Orthopaedic Research Society Spine Section (ORS3) and the more global and clinically focused International Society for the Study of the Lumbar Spine (ISSLS). The PubMed database was probed to quantify trends in the overall number of articles published, the number of journals these articles were published in, and the number of active scientists producing new manuscripts. We also evaluated trends in flagship spine journals ( Spine , European Spine Journal , and The Spine Journal ) and in the Journal of Orthopaedic Research...
March 2018: JOR spine
https://www.readbyqxmd.com/read/29769095/external-validation-of-a-prediction-model-for-surgical-site-infection-after-thoracolumbar-spine-surgery-in-a-western-european-cohort
#17
Daniël M C Janssen, Sander M J van Kuijk, Boudewijn B d'Aumerie, Paul C Willems
BACKGROUND: A prediction model for surgical site infection (SSI) after spine surgery was developed in 2014 by Lee et al. This model was developed to compute an individual estimate of the probability of SSI after spine surgery based on the patient's comorbidity profile and invasiveness of surgery. Before any prediction model can be validly implemented in daily medical practice, it should be externally validated to assess how the prediction model performs in patients sampled independently from the derivation cohort...
May 16, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29767782/factfinders-for-patient-safety-are-gadolinium-based-contrast-media-safe-alternatives-to-iodinated-contrast-agents-for-the-safe-performance-of-spinal-injection-procedures
#18
Adrian Popescu, Jaymin Patel, Zachary L McCormick, Timothy P Maus, Meghan Rodes, David R Walega, Clark C Smith
No abstract text is available yet for this article.
May 14, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29766142/improving-life-expectancy-a-broken-neck-doesn-t-have-to-be-a-terminal-diagnosis-for-the-elderly
#19
Laura N Godat, Leslie M Kobayashi, David C Chang, Raul Coimbra
Background: Elderly patients with cervical spine fractures require optimal care. Treatment with a cervical collar or halo instead of surgical fixation may increase mortality. This investigation intends to describe the life expectancy after injury and evaluate the impact of surgical intervention on mortality. Methods: Patients ≥65 years, with traumatic cervical spine fractures without cord injury were identified in the 1995-2009 California Office of Statewide Health and Planning database...
2018: Trauma surgery & acute care open
https://www.readbyqxmd.com/read/29765702/is-radiographic-progression-in-radiographic-axial-spondyloarthritis-related-to-matrix-metalloproteinase-degradation-of-extracellular-matrix
#20
Anne Sofie Siebuhr, Desirée van der Heijde, Anne-C Bay-Jensen, Morten Asser Karsdal, Robert Landewé, Astrid van Tubergen, Sofia Ramiro
Background: Radiographic axial spondyloarthritis (r-axSpA) is associated with extracellular matrix (ECM) remodelling of affected tissues. We investigated whether there was a relationship between biomarkers of ECM remodelling and 2-year radiographic progression in r-axSpA. Methods: Patients from the Outcome in Ankylosing Spondylitis International Study (OASIS) were included if they had serum, clinical and spinal radiographic assessments available at baseline and 2 years later...
2018: RMD Open
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