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https://www.readbyqxmd.com/read/28796991/epidemiology-of-intracranial-and-extracranial-large-artery-stenosis-in-a-population-based-study-of-stroke-in-the-middle-east
#1
Hamidreza Saber, Amin Amiri, Amanda G Thrift, Saverio Stranges, Reza Bavarsad Shahripour, Mohammad T Farzadfard, Naghmeh Mokhber, Réza Behrouz, Mahmoud Reza Azarpazhooh
BACKGROUND: Intracranial large-artery disease (LAD) is a predominant vascular lesion found in patients with stroke of Asian, African, and Hispanic origin, whereas extracranial LAD is more prevalent among Caucasians. These patterns are not well-established in the Middle East. We aimed to characterize the incidence, risk factors, and long-term outcome of LAD strokes in a Middle-Eastern population. METHODS: The Mashhad Stroke Incidence Study is a community-based study that prospectively ascertained all cases of stroke among the 450,229 inhabitants of Mashhad, Iran between 2006 and 2007...
August 11, 2017: Neuroepidemiology
https://www.readbyqxmd.com/read/28794567/autoimmune-bullous-disease-in-childhood
#2
Andac Salman, Burak Tekin, Deniz Yucelten
BACKGROUND: Autoimmune bullous disorders (AIBDs) are a heterogeneous group of diseases which are rarely seen in children. Studies concerning the immunobullous diseases in pediatric patients are scarce. AIMS AND OBJECTIVES: In this study, we aimed to investigate the clinical features and treatment outcomes of AIBDs in children. MATERIALS AND METHODS: The electronic records of the patients in our AIBDs outpatient clinic were retrospectively reviewed...
July 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28794353/revascularization-of-left-coronary-system-using-a-skeletonized-left-internal-mammary-artery%C3%A3-sequential-vs-separate-grafting
#3
Qiang Ji, YunQing Shi, LiMin Xia, RunHua Ma, JinQiang Shen, Hao Lai, WenJun Ding, ChunSheng Wang
BACKGROUND: To evaluate in-hospital and mid-term outcomes of sequential vs. separate grafting of in situ skeletonized left internal mammary artery (LIMA) to the left coronary system in a single-center, propensity-matched study.Methods and Results:After propensity score-matching, 120 pairs of patients undergoing first scheduled isolated coronary artery bypass grafting (CABG) with in situ skeletonized LIMA grafting to the left anterior descending artery (LAD) territory were entered into a sequential group (sequential grafting of LIMA to the diagonal artery and then to the LAD) or a control group (separate grafting of LIMA to the LAD)...
August 9, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28793054/revealing-potential-long-non-coding-rna-biomarkers-in-lung-adenocarcinoma-using-long-non-coding-rna-mediated-competitive-endogenous-rna-network
#4
T-G Zhu, X Xiao, Q Wei, M Yue, L-X Zhang
In our study, we aimed to reveal potential long non-coding RNAs (lncRNA) biomarkers in lung adenocarcinoma (LAD) using lncRNA-mediated competing endogenous RNAs (ceRNAs) network (LMCN). Competing lncRNA-mRNA interactions were identified using the hypergeometric test. Co-expression analysis for the competing lncRNA-mRNA interactions was implemented, and relying on the weight value >0.8, a highly competitive LMCN was further constructed. Degree distribution, betweenness and closeness for LMCN were carried out to analyze the network structure...
August 7, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28789842/impact-of-target-vessel-on-long-term-cardiac-mortality-after-successful-chronic-total-occlusion-percutaneous-coronary-intervention-insights-from-a-japanese-multicenter-registry
#5
Satoru Mitomo, Toru Naganuma, Richard J Jabbour, Katsumasa Sato, Hideo Takebayashi, Tsuyoshi Kobayashi, Jun-Ei Obata, Kenji Sakamoto, Kenichi Tsujita, Kiyotaka Kugiyama, Hisao Ogawa, Sunao Nakamura
BACKGROUND: The impact of successful chronic total occlusion (S-CTO) percutaneous coronary intervention (PCI) on cardiac mortality may differ depending on target CTO vessel; however, to date this has not yet been adequately evaluated. The aim of this study was to investigate the impact of target vessel on cardiac mortality after S-CTO PCI. METHODS: From January 2004 to December 2011, 1517 CTO PCIs were performed in 4 Japanese centers and enrolled in a multicenter registry...
August 4, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28789617/left-ventricular-longitudinal-function-assessment-in-rabbits-after-acute-occlusion-of-left-anterior-descending-coronary-artery-by-two-dimensional-speckle-tracking-imaging
#6
Jun Huang, Zi-Ning Yan, Li Fan, Yi-Fei Rui, Xiang-Ting Song
ABSTACT: BACKGROUND: To evaluate the left ventricular (LV) longitudinal function changes in rabbits after acute occlusion of the left anterior descending artery (LAD) by two-dimensional speckle tracking imaging (2D-STI). METHODS: Forty-eight New Zealand white rabbits underwent echocardiography examination. EchoPAC was used to measure LV peak systolic longitudinal strain (LS) of the endocardium, middle myocardium, and epicardium, peak longitudinal strain rate (LSr), segmental and global longitudinal rotation (LR) degrees...
August 8, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28776763/feasibility-symptoms-adverse-effects-and-complications-associated-with-noninvasive-assessment-of-coronary-flow-velocity-reserve-in-women-with-suspected-or-known-coronary-artery-disease
#7
Roberta Montisci, Massimo Ruscazio, Maria Francesca Marchetti, Francesca Tuveri, Cristina Cacace, Michela Congia, Norma Zedda, Luigi Meloni
BACKGROUND: Microvascular coronary impairment, defined as reduced coronary flow reserve, represents the predominant etiologic mechanism of ischemia in women with chest pain and no obstructive coronary artery disease. Transthoracic echocardiography (TTE) is a noninvasive method for assessing coronary flow velocity reserve (CFVR) in the left anterior descending coronary artery (LAD). The purpose of this investigation was to define the safety profile, feasibility, adverse events, and rate of complications of the test in women with suspected CAD...
August 3, 2017: Echocardiography
https://www.readbyqxmd.com/read/28776540/value-of-combining-left-atrial-diameter-and-amino-terminal-pro-brain-natriuretic-peptide-to-the-cha2ds2-vasc-score-for-predicting-stroke-and-death-in-patients-with-sick-sinus-syndrome-after-pacemaker-implantation
#8
Bin-Feng Mo, Qiu-Fen Lu, Shang-Biao Lu, Yu-Quan Xie, Xiang-Fei Feng, Yi-Gang Li
BACKGROUND: The CHA2DS2-VASc score is used clinically for stroke risk stratification in patients with atrial fibrillation (AF). We sought to investigate whether the CHA2DS2-VASc score predicts stroke and death in Chinese patients with sick sinus syndrome (SSS) after pacemaker implantation and to evaluate whether the predictive power of the CHA2DS2-VASc score could be improved by combining it with left atrial diameter (LAD) and amino-terminal pro-brain natriuretic peptide (NT-proBNP). METHODS: A total of 481 consecutive patients with SSS who underwent pacemaker implantation from January 2004 to December 2014 in our department were included...
August 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28776068/clinical-outcomes-of-left-main-crossover-stenting-for-ostial-left-anterior-descending-artery-acute-myocardial-infarction
#9
Kei Yamamoto, Kenichi Sakakura, Naoyuki Akashi, Yusuke Watanabe, Masamitsu Noguchi, Yousuke Taniguchi, Hiroshi Wada, Shin-Ichi Momomura, Hideo Fujita
Percutaneous coronary interventions to ostial left anterior descending artery (LAD)-acute myocardial infarction (AMI) were challenging, especially in crossover stenting from left main trunk (LMT) to LAD. The clinical outcomes of ostial LAD-AMI that needed crossover stenting were not well investigated. The objective of this study was to compare the clinical outcomes of LMT crossover stenting with those of ostial LAD just proximal (jp) stenting. Between January 2009 and March 2016, 1499 patients were diagnosed as AMI in our institution...
August 3, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28774344/late-outcome-of-surgical-radiofrequency-ablation-for-persistent-valvular-atrial-fibrillation-in-china-a-single-center-study
#10
Hailong Cao, Yunxing Xue, Qing Zhou, Minggang Yu, Chenbin Tang, Dongjin Wang
BACKGROUND: Atrial fibrillation (AF) adversely affects surgical outcomes of cardiac valve surgery. Surgical ablation is an effective way to treat valvular AF. The aim of this study was to evaluate the late outcome of surgical radiofrequency ablation and explore the risk factors of AF recurrence in Chinese patients undergoing cardiac valve surgery. METHODS: Three hundred ninety six consecutive patients with persistent valvular AF were enrolled in this study. They underwent concomitant modified Maze IV and were completed follow-ups...
August 3, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28770199/a-classification-model-to-predict-the-rate-of-decline-of-kidney-function
#11
Ersoy Subasi, Munevver Mine Subasi, Peter L Hammer, John Roboz, Victor Anbalagan, Michael S Lipkowitz
The African American Study of Kidney Disease and Hypertension (AASK), a randomized double-blinded treatment trial, was motivated by the high rate of hypertension-related renal disease in the African-American population and the scarcity of effective therapies. This study describes a pattern-based classification approach to predict the rate of decline of kidney function using surface-enhanced laser desorption ionization/time of flight proteomic data from rapid and slow progressors classified by rate of change in glomerular filtration rate...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28767385/left-anterior-descending-coronary-artery-dissection-during-ventricular-tachycardia-ablation-case-report
#12
Kordic Kresimir, Manola Sime, Zeljkovic Ivan, Benko Ivica, Pavlovic Nikola
Fascicular left ventricular tachycardia (VT) is the second most frequent idiopathic left VT in the setting of a structurally normal heart. Catheter ablation is curative in most patients with low complication rates. We report a case of ostial left anterior descending coronary artery (LAD) occlusion during fascicular ventricular tachycardia ablation. Dissection was the most likely cause of LAD obstruction. To the authors' best knowledge, this is the first case reporting selective LAD dissection during electrophysiology study with no left main coronary artery (LMCA) affection...
July 26, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28766865/trapping-as-retrieval-technique-to-resolve-a-ruptured-and-entrapped-coronary-balloon-catheter
#13
Javier León Jiménez, Jessica Roa Garrido, Santiago Jesús Camacho Freire, José Francisco Díaz Fernández
A 69 year old male, with a previous percutaneous revascularization of the mid-circumflex with a bare metal stent in 2007 was admitted to our centre for unstable angina. The angiography showed a severely calcified coronary tree with a functionally severe plaque on the proximal left anterior descending artery (LAD) and a critical focal lesion on the proximal right coronary artery. After a high pressure predilation on the proximal LAD, the balloon ruptured causing a retrograde LAD-left main (LM) dissection that was rapidly sealed with three overlapping zotarolimus-eluting stents from medial LAD to LM...
August 2, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28761561/coronary-perforation-of-distal-diagonal-branch-followed-by-prolonged-recurrent-cardiac-tamponade-finally-resolved-with-pericardiotomy-the-potential-risk-of-hydrophilic-guide-wires
#14
Rafał Januszek, Krzysztof Bartuś, Radosław Litwinowicz, Artur Dziewierz, Łukasz Rzeszutko
PURPOSE: Coronary artery perforation (CAP) is a complication of percutaneous coronary interventions (PCIs). Hydrophilic guide-wires have been shown to increase the probability of CAP. Depending on the size of perforations we adopt different treatments. CASE: We present the case of a 73-year old male with coronary artery disease and severe aortic valve stenosis. The patient was in the process of qualifying for a transcatheter aortic valve implantation. Unfortunately, CAP of the first diagonal branch of the LAD occurred during PCI...
2017: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/28755403/monitoring-deep-inspiration-breath-hold-for-left-sided-localized-breast-cancer-radiotherapy-with-an-in-house-developed-laser-distance-meter-system
#15
Christer A Jensen, Tatiana Abramova, Jomar Frengen, Jo-Åsmund Lund
Deep inspiration breath hold (DIBH) in left-sided breast cancer radiotherapy is a technique to reduce cardiac and pulmonary doses while maintaining target coverage. This study aims at evaluating an in-house developed DIBH system. Free-breathing (FB) and DIBH plans were generated for 22 left-sided localized breast cancer patients who had radiation therapy (RT) after breast-conserving surgery. All patients were treated utilizing an in-house laser distance measuring system. 50 Gy was prescribed, and parameters of interest were target coverage, left anterior descending coronary artery, (LAD) and heart doses...
July 29, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28754718/intracoronary-delivery-of-recombinant-timp-3-following-myocardial-infarction-effects-on-myocardial-remodeling-and-function
#16
Shayne C Barlow, Heather Doviak, Julia Jacobs, Lisa A Freeburg, Paige E Perreault, Kia N Zellars, Karen Moreau, Camila F Villacreses, Stephen Smith, Aarif F Khakoo, TaeWeon Lee, Francis G Spinale
BACKGROUND AND SIGNIFICANCE: Ischemia-reperfusion and myocardial infarction causes adverse LV remodeling and heart failure, facilitated by an imbalance in matrix metalloproteinase activation and the endogenous tissue inhibitors of MMPs. We identified that myocardial injections of a recombinant TIMP-3 (human full length) can interrupt post-MI remodeling. However, to what degree intracoronary delivery of rTIMP-3 post-IR is feasible and effective remained to be established. METHODS AND RESULTS: Pigs (25 kg) underwent coronary catheterization and balloon occlusion of the left anterior descending for 90 minutes whereby at the final 4 minutes, rTIMP-3 (n=9; 30 mg) or saline was infused in the distal LAD...
July 28, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28754098/longitudinal-shortening-remains-the-principal-component-of-left-ventricular-pumping-in-patients-with-chronic-myocardial-infarction-even-when-the-absolute-atrioventricular-plane-displacement-is-decreased
#17
Daniel Asgeirsson, Erik Hedström, Jonas Jögi, Ulrika Pahlm, Katarina Steding-Ehrenborg, Henrik Engblom, Håkan Arheden, Marcus Carlsson
BACKGROUND: The majority (60%) of left ventricular (LV) stroke volume (SV) is generated by longitudinal shortening causing apical atrioventricular plane displacement (AVPD) in systole. The remaining SV is caused by radial inward motion of the epicardium both in the septal and the lateral wall. We aimed to determine if these longitudinal, septal and lateral contributions to LVSV are changed in patients with chronic myocardial infarction (MI). METHODS: Patients with a chronic (>3 months) ST-elevation MI in the left anterior descending (LAD, n = 20) or right coronary artery (RCA, n = 16) and healthy controls (n = 20) were examined with cardiovascular magnetic resonance (CMR)...
July 28, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28751054/the-role-of-bioelectrical-impedance-analysis-nt-probnp-and-inferior-vena-cava-sonography-in-the-assessment-of-body-fluid-volume-in-children-with-nephrotic-syndrome
#18
Hulya Nalcacioglu, Ozan Ozkaya, Kemal Baysal, Hassan Candas Kafali, Bahattin Avci, Demet Tekcan, Gurkan Genc
BACKGROUND: Assessment of volume status and differentiating "underfill" and "overfill" edema is essential in the management of patients with nephrotic syndrome (NS). OBJECTIVES: Our aim was to evaluate the volume status of NS patients by using different methods and to investigate the utility of bioelectrical impedance analysis (BIA) in children with NS. METHODS: The hydration status of 19 patients with NS (before treatment of NS and at remission) and 25 healthy controls was assessed by multifrequency BIA, serum N-terminal-pro-brain natriuretic peptide (NT-proBNP) levels, inferior vena cava (IVC) diameter, left atrium diameter (LAD) and vasoactive hormones...
July 24, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28750824/syntax-score-and-pre-and-poststent-optical-coherence-tomography-findings-in-the-left-anterior-descending-coronary-artery-in-patients-with-stable-angina-pectoris
#19
Krzysztof L Bryniarski, Darren L Walters, Chong-Jin Kim, Tsunenari Soeda, Takumi Higuma, Erika Yamamoto, Lei Xing, Tomoyo Sugiyama, Thomas Zanchin, Leszek Bryniarski, Dariusz Dudek, Hang Lee, Ik-Kyung Jang
SYNTAX score (SS) has been reported to be an independent predictor of future cardiac events including target lesion revascularization. The aim of this study was to assess the relation between SS and plaque characteristics and poststent vascular response using optical coherence tomography in coronary artery tree and left anterior descending artery (LAD) in patients with stable angina. A total of 179 lesions among 165 patients, including 100 lesions in LAD, were analyzed. Patients were stratified into tertiles...
June 28, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28750662/impact-of-hypertension-with-or-without-diabetes-on-left-ventricular-remodeling-in-rural-chinese-population-a-cross-sectional-study
#20
Tan Li, Shuang Chen, Xiaofan Guo, Jun Yang, Yingxian Sun
BACKGROUND: The aim of this study was to assess the impact of hypertension with or without diabetes on left ventricular (LV) remodeling in rural Chinese population. METHODS: A total of 10,270 participants were classified into control group, hypertension without diabetes (HT) group, and hypertension with diabetes (HT + DM) group. We compared clinical characteristics and echocardiographic parameters, and used multivariable logistic regression analysis to assess the associations of interest...
July 27, 2017: BMC Cardiovascular Disorders
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