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https://www.readbyqxmd.com/read/28087144/-contribution-of-microbiology-in-the-diagnosis-of-tuberculosis-in-castile-and-le%C3%A3-n-spain-findings-of-the-grumicale-2013-study
#1
Ramiro López-Medrano, Teresa Nebreda-Mayoral, M Fé Brezmes-Valdivieso, Susana García-de Cruz, Begoña Nogueira-González, Rafael Sánchez-Arroyo, Almudena Tinajas-Puertas, Nieves Gutiérrez-Zufiaurre, Cristina Labayru-Echeverría, Susana Hernando-Real, Luis López-Urrutia, Octavio Rivero-Lezcano, Belén Ullivarri-Francia, Raquel Rodríguez-Tarazona, Isabel Antolín-Ayala
INTRODUCTION AND OBJECTIVES: A retrospective study was conducted by collecting microbiological tuberculosis (TB) data in Castile and León during the year 2013 in order to determine the incidence and distribution of TB, and resistance to the tuberculostatic drug, and compare them with the epidemiological data provided by the Department of Epidemiological Surveillance (SIVE). MATERIAL AND METHODS: Microbiologists of the 14 hospitals of the Castile and León public health network (GRUMICALE) collected epidemiological, microbiological, and management data from the Microbiology laboratories in the community during the year 2013...
January 10, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28079399/safety-and-efficacy-of-tissue-plasminogen-activator-tpa-and-deoxyribonuclease-dnase-for-complicated-pleural-effusions-secondary-to-abdominal-pathology
#2
Adnan Majid, Sebastian Ochoa, Sumit Chatterji, Sebastian Fernandez-Bussy, Fayez Kheir, Estefania Rivera, George Cheng, Erik Folch
RATIONALE: Exudative pleural effusions may arise secondary to inflammation of intra-abdominal structures. Pleural space loculations can complicate these effusions, preventing adequate chest tube drainage and leading to consideration of surgical intervention. Previous studies have demonstrated that intrapleural administration of tissue plasminogen activator (tPA) combined with human recombinant deoxyribonuclease (DNase) can improve fluid drainage and reduce surgery for patients with loculated parapneumonic effusions; however, the efficacy of this treatment has not been evaluated for complicated pleural effusions attributed to intraabdominal inflammation...
January 12, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28078848/clinical-effects-of-thermotherapy-in-combination-with-intracavitary-infusion-of-traditional-chinese-medicine-in-the-treatment-of-malignant-pleural-effusion
#3
Y Gu, L Jiang, J H Miao, T S Liang, Q C Kan, D K Yang
Malignant fluid, a commonly seen tumor associated complication, mainly includes peritoneal effusion, malignant pleural effusion and pericardial effusion. It can produce huge negative influence on the quality of life of patients and even lead to death. Treatment of malignant effusion is one of the effective measures for improving life expectancy of patients. To evaluate the effect of thermotherapy in combination with intracavitary infusion of Kangai injection in treating malignant pleural effusion, 195 patients who received treatment from April 2010 to October 2014 in the First Affiliated Hospital of Zhengzhou University were selected and divided into an observation group and two control groups (group A and B)...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28073871/benign-cystic-mediastinal-teratoma-presenting-as-a-massive-pleural-effusion-in-a-17-year-old-boy
#4
Annalisa Montebello, Adrian Mizzi, Paul John Cassar, Karen Cassar
Mediastinal teratomas are a rare, albeit an important differential diagnosis of anterior/middle mediastinal masses in young adults and various atypical presentations have been reported. The authors report a case of a 17-year-old boy who presented with a 2-month history of worsening shortness of breath and pleuritic chest pain. A massive left-sided pleural fluid collection was seen on a chest radiograph (CXR). The pleural fluid was drained and a CT Thorax confirmed the presence of a cystic mass. Following re-accumulation of the fluid, thoracotomy was performed and a benign mediastinal teratoma excised...
January 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28072959/-diagnosis-of-pulmonary-hemorrhage-of-the-newborn-infants-using-lung-ultrasonography
#5
J Liu, W Fu, S W Chen, Y Wang
Objective: To investigate the accuracy and reliability of lung ultrasound in diagnosis of pulmonary hemorrhage of the newborn infants. Method: From January 2014 to May 2016, 142 neonates from the Army General Hospital of the Chinese PLA were enrolled in the study. They were divided into two groups: a study group of 42 neonates, who were diagnosed with pulmonary hemorrhage according to their medical history, clinical manifestations and chest X-ray findings, and a control group of 100 neonates with no lung disease...
January 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28057604/biological-markers-in-the-diagnosis-of-tuberculous-pleural-effusion
#6
Bastien Mollo, Stéphane Jouveshomme, François Philippart, Benoît Pilmis
Tuberculosis is one of the main etiologies to evoke in the context of lymphocyte pleurisy. However, diagnosis is difficult and is based on mycobacteriology that is not enough sensitive and time-consuming, or on histology that requires invasive biopsy gesture. This literature review, carried out from Medline, summarizes the main meta-analyzes, reviews, and originator publications in English on biomarkers, classic and more innovative, studied for the diagnosis of tuberculous pleurisy. Among the immuno-biochemical markers, interferon-γ (IFN-γ), isoenzyme of adenosine deaminase 2 (ADA2) and total adenosine deaminase (ADA) seem the most relevant with respective sensitivities of 89% (87-91), 97...
January 5, 2017: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/28043549/effect-of-time-duration-of-digestion-decontamination-technique-on-yield-of-mycobacteria-and-contamination-rates-from-sterile-body-fluids-pleural-and-ascitic-fluid-and-pus-specimens
#7
Samreen Shafiq, Faryal Saleem, Kauser Jabeen, Joveria Farooqi, Warda Alam, Sadia Hanif, Shazia Ali, Sadia Shakoor, Rumina Hasan
BACKGROUND: Duration of digestion/decontamination has a considerable impact on yield of mycobacteria especially from sterile body fluids and pus specimens. Additionally, duration of digestion/decontamination affects the contamination rates. This study evaluates the effect of digestion/decontamination protocol for 15 and 20min versus inoculation of media directly from the sample on contamination rates as well as the yield of mycobacteria from pus and sterile fluids other than cerebrospinal fluids...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28043494/yield-of-mycobacteriological-study-in-diagnosis-of-pleural-tuberculosis-among-human-immune-deficiency-virus-infected-patients
#8
Majid Marjani, Amir Yousefzadeh, Payam Tabarsi, Afshin Moniri, Ali Akbar Velayati
BACKGROUND: Pleural tuberculosis (TB) is common among HIV-infected patients. In the absence of HIV infection, the yield of mycobacteriological study is low and usually invasive procedures, including pleural fluid analysis and pleural biopsy, are necessary. The present study aimed to determine the yield of mycobacteriological study of sputum and pleural fluid among HIV-infected patients. METHODS: This retrospective case-control study involved HIV-positive and HIV-negative patients with new pleural TB admitted to the National Research Institute of Tuberculosis and Lung Disease, Tehran, Iran, for 5years...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28042214/study-of-invasive-pneumococcal-infection-in-adults-with-reference-to-penicillin-resistance
#9
Vrishali Avinash Muley, Dnyaneshwari Purushottam Ghadage, Gauri Eknath Yadav, Arvind Vamanrao Bhore
BACKGROUND: Invasive pneumococcal infections often prove rapidly fatal, even where good medical treatment is readily available. In developed countries, up to 20% of people who contract pneumococcal meningitis die; however, in developing world, mortality is closer to 50%, even among hospitalized patients. The World Health Organization estimated 600,000-800,000 adult deaths each year from pneumococcal pneumonia, meningitis, and sepsis. AIMS: This study aims to estimate isolation rate of invasive pneumococcal infection in adults, to determine the antimicrobial susceptibility profile of Streptococcus pneumoniae isolates and to study the associated risk factors...
January 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28039396/systematic-review-and-meta-analysis-of-vascular-endothelial-growth-factor-as-a-biomarker-for-malignant-pleural-effusions
#10
Eleftheria Fafliora, Chrissi Hatzoglou, Konstantinos I Gourgoulianis, Sotirios G Zarogiannis
Conventional methods may fail to identify the cause of pleural effusion (PE), thus establishing reliable biomarkers is deemed necessary. This study aimed at examining the role of vascular endothelial growth factor (VEGF) as a biomarker in the differentiation between malignant and benign PEs in adults. A comprehensive literature search in PubMed (Medline), Scopus (ELSEVIER), and Cochrane Central Register of Controlled Trials (CENTRAL) databases was conducted using keywords. We included studies that evaluated pleural and/or serum levels of VEGF among patients presenting with undiagnosed PE and the association between these levels and the final diagnosis...
December 2016: Physiological Reports
https://www.readbyqxmd.com/read/28038770/examination-of-cytological-smears-and-cell-blocks-of-pleural-fluid-complementary-diagnostic-value-for-malignant-effusions
#11
J M Porcel, M Quirós, S Gatius, S Bielsa
OBJECTIVES: To evaluate the independent usefulness of pleural fluid smear and cell block (CB) preparations for the diagnosis of malignant effusions. PATIENTS AND METHODS: A total of 632 cytological smears and 554 CBs from 414 consecutive patients with malignant effusions were retrospectively evaluated. RESULTS: The diagnostic yield of a first specimen was 44% regardless of whether a smear or CB cytologic examination was performed. The use of subsequent separated specimens increased the identification of malignancy to 56%...
December 27, 2016: Revista Clínica Española
https://www.readbyqxmd.com/read/28035466/a-rare-postoperative-complication-of-anterior-lower-thoracic-instrumentation-diaphragmatic-laceration-with-hemothorax
#12
Yat Wa Wong, Jason Pui Yin Cheung, Keith Dip Kei Luk, Kenneth Man Chee Cheung
PURPOSE: To highlight the importance of preventing visceral injury due to prominent anterior implants at the spinal column. METHODS: A 52-year-old man with cord compression was treated with a T9/10 discectomy and instrumented fusion via a right thoracotomy and trans-pleural approach. Postoperatively, he had improved lower limb numbness. However, after a bout of coughing, there was sudden increase in chest drain output, hemodynamic instability and massive fluid collection in the right chest cavity...
December 29, 2016: European Spine Journal
https://www.readbyqxmd.com/read/28031839/a-massive-pleural-based-desmoid-tumour
#13
Talha Mahmud, Guness Mal, Farhan Ahmed Majeed, Siaw Ming Chai, Y C Gary Lee
A 49-year-old Pakistani male presented with "heaviness" in his chest. Chest radiograph and computed tomography (CT) confirmed a massive left-sided pleural-based opacity. Three years ago, he was investigated for a left-sided lymphocytic, exudative pleural effusion following an episode of dengue fever. Tube thoracostomy removed 1.3 L of fluid. Pleural biopsy and bronchial washings were non-contributory. He received empirical anti-tuberculosis treatment and remained asymptomatic until this presentation. To investigate the new pleural mass, he underwent a video-assisted thoracoscopic surgery, which revealed a 2...
January 2017: Respirology Case Reports
https://www.readbyqxmd.com/read/28024452/positive-predictive-value-of-elispot-in-bal-and-pleural-fluid-from-patients-with-suspected-pulmonary-tuberculosis
#14
Regina W Hofland, Steven F T Thijsen, Anne S R van Lindert, Wiel C M de Lange, Tamara van Gorkom, Ingeborg van der Tweel, Jan-Willem J Lammers, Aik W J Bossink
BACKGROUND: The aim of this study was to evaluate the positive predictive value (PPV) of ELISpot in bronchoalveolar lavage (BAL) and pleural fluid for the diagnosis of active tuberculosis (TB) in real-life clinical practice, together with the added value of a cut-off >1.0 for the ratio between the extra-sanguineous and systemic interferon-gamma responses in positive samples. METHODS: A retrospective, single-centre study was performed. Patients with positive ELISpot in BAL and pleural fluid were included...
December 26, 2016: Infectious Diseases
https://www.readbyqxmd.com/read/28024110/the-importance-of-ezh2-and-moc-31-expression-in-the-differential-diagnosis-of-benign-and-malignant-effusions
#15
Canan Sadullahoglu, Deniz Nart, Ali Veral
BACKGROUND: All malignant tumors may spread throughout the pleural, peritoneal, and pericardial cavities. The presence of tumor cells in serosal fluid is a poor prognostic indicator. It may be difficult to differentiate nuclear atypia of mesothelial cells due to injury of serosal surfaces from mesothelioma or malignant epithelial tumor cells. Epithelial and mesothelial immunohistochemical markers can be used in such conditions. The aim of this study was to evaluate the expression of two immunohistochemical markers (MOC-31 and EZH2) in serosal effusions...
December 26, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28002541/distinction-between-mesothelioma-and-lung-adenocarcinoma-based-on-immunohistochemistry-in-a-patient-with-asbestos-bodies-in-bronchoalveolar-fluid-case-report
#16
Agripina Raşcu, Eugenia Naghi, Marina Ruxandra OŢelea, Floarea Mimi NiŢu, Oana Cristina Arghir
Asbestos is a mineral-mined form the rocks, consisting in amosite (brown asbestos), crocidolite (blue asbestos) and÷or chrysotile (white asbestos) used in many industries. Researches about the exposure to asbestos dust and asbestosis related diseases started almost a century ago. The first case report of fatal asbestosis disease was published in 1906, in England, by Dr. Hubert Montague Murray. A decade after, asbestos "curious bodies" were firstly described in the lung tissue by Cooke (1926) and McDonald (1927)...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27993288/diagnosis-of-complicated-parapneumonic-effusion-by-pleural-ph-measurement-is-jeopardized-by-inadequate-physician-knowledge-and-guideline-discordant-laboratory-practice
#17
Lauren Ng, Eli Dabscheck, Mark Hew
Pleural fluid pH is a crucial determinant of complicated parapneumonic effusion diagnosis and the need for drainage. It is best measured by blood gas analyzer. We examined whether physicians were aware of this, and whether their laboratories measured pleural pH according to their expectations. Only 53% of physicians understood the need for blood gas analyzer measurements, only 50% of laboratories used blood gas analyzers, and only 35% of physicians correctly identified the method performed in their laboratory...
January 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/27986362/acute-focal-bacterial-nephritis-in-a-cohort-of-hospitalized-adult-patients-with-acute-pyelonephritis-assessment-of-risk-factors-and-a-predictive-model
#18
Joaquin Campos-Franco, Cristina Macia, Emilio Huelga, Carla Diaz-Louzao, Francisco Gude, Rosario Alende, Arturo Gonzalez-Quintela
BACKGROUND: Acute focal bacterial nephritis (AFBN) is a complicated form of acute pyelonephritis (APN) characterized by single or multiple areas of localised infection in the kidney without liquefaction or abscess. Studies investigating AFBN in adults are scarce. AIM: The present study was aimed at evaluating the prevalence, associated factors, and presence of atypical clinical and radiological manifestations in adult AFBN patients. Also, we developed a clinical prediction model to evaluate the probability of AFBN in patients with APN...
December 13, 2016: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/27984384/mixing-it-up-coadministration-of-tpa-dnase-in-complicated-parapneumonic-pleural-effusions-and-empyema
#19
Raju Bishwakarma, Shiwan Shah, Luba Frank, Wei Zhang, Gulshan Sharma, Shawn P E Nishi
BACKGROUND: A recent randomized controlled trial showed 12 serial doses of tissue plasminogen activator (tPA) and deoxyribonuclease (DNase) is safe and effective in managing complicated parapneumonic pleural effusions and empyema (CPEE). However, this regimen is laborious, requiring trained personnel to open/close the chest tube 8 times daily for 3 days. We present our observational data using a simplified regimen of coadministered tPA/DNase. MATERIALS AND METHODS: This is a retrospective observational study of patients who received coadministered tPA/DNase for CPEE from January 2012 to April 2015 at the University of Texas Medical Branch...
January 2017: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/27981931/pleural-effusion-developing-in-two-patients-on-continuous-ambulatory-peritoneal-dialysis
#20
Muhammad Asim
Two patients with end-stage-renal-disease on continuous ambulatory peritoneal dialysis (CAPD) presented with pleural effusions. The aspirated fluid was categorised as transudate, based on alkaline pH, low protein and lactic dehydrogenase level. A striking feature of the pleural fluid was, its very high glucose content that resulted from translocation of dextrose containing peritoneal dialysate into the pleural space via a pleuroperitoneal connection. One patient was transferred to hemodialysis, which led to complete resolution of pleural effusion...
November 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
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