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https://www.readbyqxmd.com/read/29123888/cardiac-arrest-caused-by-rapidly-increasing-ascites-in-a-patient-with-tafro-syndrome-a-case-report
#1
Masatoshi Okumura, Atsushi Ujiro, Yasunori Otsuka, Hiroshi Yamamoto, Sho Wada, Hirofumi Iwata, Toshiaki Kan, Seiji Miyauchi, Atsushi Hashimoto, Yuko Sato, Yoshihito Fujita, Yoshihiro Fujiwara, Hideki Shimaoka
Case: Thrombocytopenia, anasarca, fever, renal insufficiency, and organomegaly (TAFRO) syndrome is a newly defined systemic inflammatory disorder with gradual progression of symptoms. A 59-year-old man with fever and ascites of unknown cause developed sudden-onset shock and respiratory failure in the general ward. Cardiac arrest immediately followed. Although he was resuscitated, frequent administration of adrenaline was required to maintain his blood pressure. His circulation was most effectively stabilized by drainage of fluid from his distended abdomen...
July 2017: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29109849/current-concepts-and-future-strategies-in-the-antimicrobial-therapy-of-emerging-gram-positive-spontaneous-bacterial-peritonitis
#2
REVIEW
Marco Fiore, Alberto Enrico Maraolo, Ivan Gentile, Guglielmo Borgia, Sebastiano Leone, Pasquale Sansone, Maria Beatrice Passavanti, Caterina Aurilio, Maria Caterina Pace
Spontaneous bacterial peritonitis (SBP) is the most common infection in end-stage liver disease patients. SBP is defined as an ascitic fluid infection with a polymorphonuclear leucocyte count ≥ 250/mm(3) without an evident intra-abdominal surgically treatable source. Several mechanisms contribute to SBP occurrence, including translocation of gut bacteria and their products, reduced intestinal motility provoking bacterial overgrowth, alteration of the gut's barrier function and local immune responses. Historically, Gram-negative enteric bacteria have been the main causative agents of SBP, thereby guiding the empirical therapeutic choice...
October 28, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/29100353/ascites-derived-il-6-and-il-10-synergistically-expand-cd14-hla-dr-low-myeloid-derived-suppressor-cells-in-ovarian-cancer-patients
#3
Liangliang Wu, Zhaoyang Deng, Yaojun Peng, Lu Han, Jing Liu, Linxiong Wang, Bohua Li, Jian Zhao, Shunchang Jiao, Huafeng Wei
Myeloid-derived suppressor cells (MDSC) play a key immunosuppressive role in various types of cancer, including ovarian cancer (OC). In this study, we characterized CD14(+)HLA-DR(-/lo) MDSC with a typical monocytic phenotype (M-MDSC) in the peripheral blood (PB) and ascites from OC patients. Compared to healthy donors, OC patients had a significantly increased abundance of M-MDSC in both PB and ascites; importantly, their abundance in both compartments was inversely associated with the prognosis where OC patients with higher level of M-MDSC having a shorter relapse-free survival...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29099103/detecci%C3%A3-n-molecular-de-especies-de-candida-en-espec%C3%A3-menes-de-pacientes-hospitalizados
#4
José Luis Camacho-Cardoso, María Ángeles Martínez-Rivera, Patricia Manzano-Gayosso, Luis Javier Méndez-Tovar, Rubén López-Martínez, Francisca Hernández-Hernández
Objective: To identify the most frequent Candida species in specimens from patients hospitalized in different medical centers of Mexico City, with suspected fungal infection. Methods: Specimens were grown on Sabouraud dextrose agar at 28°C for 72 h. In addition, DNA was extracted. Isolates were grown on CHROMagar Candida™, at 37°C for 48 h. The molecular identification was performed by polymerase chain reaction (PCR) using primers specific for four species. Results: Eighty one specimens were processed and included: bronchial lavage, pleural, cerebrospinal, peritoneal, ascites and bile fluids; blood, sputum, bone marrow, oro-tracheal cannula and ganglion...
2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/29095848/clinical-relevance-of-kallikrein-related-peptidase-9-10-11-and-15-mrna-expression-in-advanced-high-grade-serous-ovarian-cancer
#5
Xiaocong Geng, Yueyang Liu, Sandra Diersch, Matthias Kotzsch, Sabine Grill, Wilko Weichert, Marion Kiechle, Viktor Magdolen, Julia Dorn
KLK9, 10, 11, and 15 may represent potential cancer biomarkers for evaluating ovarian cancer prognosis. In the present study, we selected a homogeneous cohort including 139 patients of advanced high-grade serous ovarian cancer (FIGO stage III/IV) and assessed the mRNA levels of KLK9, 10, 11, and 15 in tumor tissue by quantitative PCR. No significant associations of KLK9, 10, 11, and 15 mRNA with established clinical parameters (residual tumor mass, ascitic fluid volume) were found. Pronounced correlations between KLK10/KLK11 (rs = 0...
2017: PloS One
https://www.readbyqxmd.com/read/29090239/retroperitoneal-fibrosis-as-a-cause-of-chylous-ascites
#6
Adnan Ur Rahman, Rajeswari Ramaraj, Emyr Humphreys, Elizabeth Slowinska
Retroperitoneal fibrosis is a rare condition characterized by chronic inflammation and marked fibrosis of the retroperitoneal tissue, often leading to entrapment of abdominal organs. We report a 69-year-old white man who presented with a 5-week history of gradual onset of progressive abdominal distension. He had no history or risk factors for an underlying liver condition. Ascites and a retroperitoneal mass encasing the major abdominal vessels were revealed on imaging. Biopsies of the mass confirmed the presence of retroperitoneal fibrosis, and the ascitic fluid was milky, consistent with chylous ascites...
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/29081656/spontaneous-peritonitis-in-critically-ill-cirrhotic-patients-a-diagnostic-algorithm-for-clinicians-and-future-perspectives
#7
Marco Fiore, Alberto Enrico Maraolo, Sebastiano Leone, Ivan Gentile, Arturo Cuomo, Vincenzo Schiavone, Sabrina Bimonte, Maria Caterina Pace, Marco Cascella
Spontaneous peritonitis (SP) is the most common infection among decompensated end-stage liver disease patients. SP is the infection of ascitic fluid (neutrophil ascitic count ≥250/mL) without an alternative focus of abdominal infection. According to the causative agent, clinicians can make the diagnosis of spontaneous bacterial peritonitis or spontaneous fungal peritonitis. The mortality rate is very high, ranging from one-fifth of the patients with spontaneous bacterial peritonitis to four-fifths of the patients with spontaneous fungal peritonitis...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29079220/himatanthus-drasticus-apocynaceae-latex-reduces-oxidative-stress-and-modulates-cd4-cd8-foxp3-and-hsp-60-expressions-in-sarcoma-180-bearing-mice
#8
Glauco Jonas Lemos Santos, Emanuele Silva Oliveira, Ana Débora Nunes Pinheiro, Patricia Marçal da Costa, José Claudio Carneiro de Freitas, Francisco Glauco de Araújo Santos, Fernanda Maria Machado Maia, Selene Maia de Morais, Diana Célia Sousa Nunes-Pinheiro
ETHNOPHARMACOLOGICAL RELEVANCE: In Brazil, the latex of Himatanthus drasticus is used to treat inflammation, wound healing and cancer. The present study evaluated the antitumoral potential of H. drasticus latex (HdCL) in Sarcoma 180-bearing mice (S180). MATERIALS, METHODS: HdCL was obtained in Crato-CE, Brazil. Qualitative phytochemicals assays, nuclear magnetic resonance (NMR) and microbiological analyzes were performed. Swiss mice were divided into six groups, according to tumor forms: 1) ascitic model, GI (Control; 0...
October 24, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29076695/broad-ligament-haematoma-following-normal-vaginal-delivery
#9
Faiza Ibrar, Azra Saeed Awan, Touseef Fatima, Hina Tabassum
A 37-year-old, patient presented in emergency with history of normal vaginal delivery followed by development of abdominal distention, vomiting, constipation for last 3 days. She was para 4 and had normal vaginal delivery by traditional birth attendant at peripheral hospital 3 days back. Imaging study revealed a heterogeneous complex mass, ascites, pleural effusion, air fluid levels with dilatation gut loops. Based upon pelvic examination by senior gynaecologist in combination with ultrasound; a clinical diagnosis of broad ligament haematoma was made...
July 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29076544/non-immune-hydrops-fetalis-do-placentomegaly-and-polyhydramnios-matter
#10
Victoria K Berger, Teresa N Sparks, Angie C Jelin, Chris Derderian, Cerine Jeanty, Kristen Gosnell, Tippi Mackenzie, Juan M Gonzalez
OBJECTIVES: Polyhydramnios and placentomegaly are commonly observed in nonimmune hydrops fetalis (NIHF); however, whether their ultrasonographic identification is relevant for prognosis is controversial. We evaluated outcomes of fetal or neonatal death and preterm birth (PTB) in cases of NIHF alone and in those with polyhydramnios and/or placentomegaly (P/PM). METHODS: We conducted a retrospective cohort of singletons with NIHF evaluated between 1994 and 2013. Nonimmune hydrops fetalis was defined as 2 or more abnormal fluid collections, including ascites, pericardial effusion, pleural effusion, and skin edema...
October 27, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29059269/the-practice-and-implications-of-finding-fluid-during-point-of-care-ultrasonography-a-review
#11
Rachel B Liu, Joseph H Donroe, Robert L McNamara, Howard P Forman, Chris L Moore
Importance: Point-of-care ultrasonography (POCUS) is an increasingly affordable and portable technology that is an important part of 21st-century medicine. When appropriately used, POCUS has the potential to expedite diagnosis and improve procedural success and safety. POCUS is now being adopted in medical education as early as the first year of medical school. While potentially powerful and versatile, POCUS is a user-dependent technology that has not been formalized or standardized yet within internal medicine residency training programs...
October 23, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29049187/a-myeloid-sarcoma-involving-the-small-intestine-kidneys-mesentery-and-mesenteric-lymph-nodes-a-case-report-and-literature-review
#12
REVIEW
Ping Wang, Quan Li, Li Zhang, Hong Ji, Cheng-Zhou Zhang, Bin Wang
RATIONALE: Myeloid sarcomas (MSs) are rare malignant hematological tumors. They most commonly occur in patients with acute or chronic myeloid leukemia. A de novo MS with no evidence of blood system disease is rare, but may represent the first sign of a systemic illness that precedes a full-blown disease. Herein, we report the computed tomography (CT) findings of an extremely rare case of a nonleukemic MS that progressed to acute myelogenous leukemia (AML) and simultaneously involved the small intestine, kidneys, mesentery, and mesenteric lymph nodes...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29047195/hepatic-transudation-barrier-properties
#13
R M Dongaonkar, R H Stewart, C M Quick, K L Uray, C S Cox, G A Laine
OBJECTIVE: Fluid and protein continuously transudes from the surface of the liver. Despite a common understanding that transudation plays a critical role in hepatic interstitial and peritoneal fluid balance, transudation from the entire liver has not been studied. Therefore, the goal of the present work was to provide the first direct measurement of the hepatic transudation rate and transudation barrier properties. METHODS: Transudation rates were determined by collecting transudate from the entire liver...
October 19, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29043711/the-many-guises-of-endometriosis-giant-abdominal-wall-endometriosis-masquerading-as-an-incisional-hernia
#14
Chiara Petrosellini, Sala Abdalla, Tayo Oke
Endometriosis is defined by the presence of ectopic endometrial tissue outside the uterine cavity. Although it is a leading cause of chronic pelvic pain and infertility, its clinical presentation can vary, resulting in diagnostic and therapeutic challenges. Extrapelvic endometriosis is particularly difficult to diagnose owing to its ability to mimic other conditions. Endometrial tissue in a surgical scar is uncommon and often misdiagnosed as a granuloma, abscess, or malignancy. Cyclical hemorrhagic ascites due to peritoneal endometriosis is exceptionally rare...
January 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29027395/prognostic-value-of-programmed-death-ligand-1-pd-l1-expression-in-ovarian-clear-cell-carcinoma
#15
Jun Zhu, Hao Wen, Rui Bi, Yong Wu, Xiaohua Wu
OBJECTIVE: Programmed death-ligand 1 (PD-L1) was expressed in various tumors and antibodies targeting its receptor programmed cell death-1 (PD-1) are emerging cancer therapeutics. This study was designed to evaluate the expression of PD-L1 and its correlation with clinicopathologic features and clinical outcomes in ovarian clear cell carcinoma (OCCC). METHODS: The PD-L1 expression was measured by tissue-microarray-based immunohistochemistry from 122 eligible patients diagnosed with OCCC...
November 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28993771/tumor-derived-microvesicles-modulate-antigen-cross-processing-via-reactive-oxygen-species-mediated-alkalinization-of-phagosomal-compartment-in-dendritic-cells
#16
Federico Battisti, Chiara Napoletano, Hassan Rahimi Koshkaki, Francesca Belleudi, Ilaria Grazia Zizzari, Ilary Ruscito, Sara Palchetti, Filippo Bellati, Pierluigi Benedetti Panici, Maria Rosaria Torrisi, Giulio Caracciolo, Fabio Altieri, Marianna Nuti, Aurelia Rughetti
Dendritic cells (DCs) are the only antigen-presenting cells able to prime naïve T cells and cross-prime antigen-specific CD8(+) T cells. Their functionality is a requirement for the induction and maintenance of long-lasting cancer immunity. Albeit intensively investigated, the in vivo mechanisms underlying efficient antigen cross-processing and presentation are not fully understood. Several pieces of evidence indicate that antigen transfer to DCs mediated by microvesicles (MVs) enhances antigen immunogenicity...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28989921/gonadotropin-releasing-hormone-antagonist-administration-for-treatment-of-early-type-severe-ovarian-hyperstimulation-syndrome-a-case-series
#17
Dayong Lee, Se Jeong Kim, Yeon Hee Hong, Seul Ki Kim, Byung Chul Jee
OBJECTIVE: To report an efficacy of gonadotropin releasing hormone (GnRH) antagonist administration after freezing of all embryos for treatment of early type ovarian hyperstimulation syndrome (OHSS). METHODS: In 10 women who developed fulminant early type OHSS after freezing of all embryos, GnRH antagonist (cetrorelix 0.25 mg per day) was started at the time of hospitalization and continued for 2 to 4 days. Fluid therapy and drainage of ascites was performed as usual...
September 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28988869/multiple-locus-variable-number-tandem-repeat-analysis-in-salmonella-isolates-as-an-effective-molecular-subtyping-method
#18
Atieh Hashemi, Fahimeh Baghbani-Arani, Sepideh Ahmadiyan, Sarvenaz Ghavami-Nejad
Due to the limitations of serotyping, to differentiate closely related microbial isolates and to investigate disease outbreaks, molecular genotyping methods including multiple loci variable number of tandem repeats (VNTR) analysis (MLVA) has been developed. The usefulness of MLVA was recently demonstrated for Salmonella Infantis and Salmonella Enteritidis isolated from human sources in Iran. In the present study. The discriminatory ability of this method was investigated in 78 Iranian Salmonella enterica isolates...
October 6, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28982257/prognostic-value-of-lectin-pathway-molecules-and-complement-proteins-in-ascitic-fluid-and-blood-in-patients-with-liver-cirrhosis
#19
Signe Glargaard, Trine Boysen, Katrine Pilely, Peter Garred, Henriette Ytting
BACKGROUND AND AIM: Patients with liver cirrhosis and ascites have a poor prognosis with increased risk of infection related death, as advanced stages of cirrhosis are associated with immunodeficiency. We aimed to investigate immunologically active molecules in ascitic fluid and blood and their potential association to survival. MATERIALS AND METHODS: In an exploratory pilot study; blood and ascitic fluid from 34 patients with liver cirrhosis of different etiology were analyzed for pattern recognition molecules (ficolin-1, ficolin-2, ficolin-3 and MBL) and complement proteins (C4 and C3)...
October 6, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28974507/isolated-ascites-in-a-newborn-with-apple-peel-jejunal-atresia
#20
Otilia Osmulikevici, Elizabeth Renji, Bruce Jaffray, Nicholas Embleton
Isolated fetal ascites was diagnosed at 20 weeks in a primiparous woman with no significant medical history. Progressive fetal ascites worsened after 28 weeks and resulted in fetal hydroceles. Delivery was by caesarian section at 33 weeks, preceded by reduction of fetal ascites under ultrasound guidance. Following delivery, the baby required further reduction of abdominal fluid and endotracheal intubation to provide respiratory support. An extensive set of investigations, including metabolic and genetic screening, was performed; all results were negative...
October 3, 2017: BMJ Case Reports
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