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https://www.readbyqxmd.com/read/29468228/two-cases-of-differentiation-syndrome-with-ocular-manifestations-in-patients-with-acute-promyelocytic-leukaemia-treated-with-all-trans-retinoic-acid-and-arsenic-trioxide
#1
A R Newman, B Leung, A Richards, T G Campbell, J Wellwood, F R Imrie
Purpose: To describe two cases of differentiation syndrome presenting with ocular manifestations including bilateral chorioretinopathy in patients with acute promyelocytic leukaemia treated with all-trans retinoic acid and arsenic trioxide differentiation therapy. Observations: This observational case series identifies two patients at a single tertiary institution diagnosed with differentiation syndrome with associated ophthalmic involvement. Both patients reported bilateral reduction in visual acuity at days fourteen and ten respectively following initiation of differentiation therapy in addition to developing other systemic manifestations of differentiation syndrome...
March 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29442283/eplerenone-versus-observation-in-the-treatment-of-acute-central-serous-chorioretinopathy-a-retrospective-controlled-study
#2
Ilaria Zucchiatti, Riccardo Sacconi, Maria Cristina Parravano, Eliana Costanzo, Lea Querques, Daniela Montorio, Francesco Bandello, Giuseppe Querques
INTRODUCTION: To investigate the effects of eplerenone compared to observation in the treatment of acute central serous chorioretinopathy (CSC). METHODS: Charts of consecutive patients with a diagnosis of acute CSC (visual symptoms < 12 weeks) were reviewed. Included patients were divided into a treatment group (treated with eplerenone) and a control group (observation). Main outcome measures included changes in best-corrected visual acuity (BCVA), central macular thickness (CMT), height of subretinal fluid (SRF) and subfoveal choroidal thickness (CT) at 1 and 3 months in the two groups...
February 13, 2018: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/29429986/comparison-of-photodynamic-therapy-and-navigated-microsecond-laser-for-chronic-central-serous-chorioretinopathy
#3
Cyprian Gabriel Ntomoka, Bindu Rajesh, Gachago Muchai Muriithi, Abhilash Goud, Jay Chhablani
OBJECTIVES: To compare the visual and anatomical outcomes after photodynamic therapy (PDT) and navigated microsecond laser (nMSL) for chronic central serous chorioretinopathy (CSCR). METHODS: This retrospective study included eyes with chronic CSCR who underwent either PDT or nMSL with a minimum of 6 months' follow-up. Eyes with a history of treatment with any other modalities in the past or during 6 months post PDT or microsecond laser follow-up were excluded. Primary outcome measures included change in best-corrected visual acuity (BCVA) and central macular thickness (CMT)...
February 12, 2018: Eye
https://www.readbyqxmd.com/read/29429592/%C3%AE-glutamyl-cyclotransferase-contributes-to-tumor-progression-in-high-grade-serous-ovarian-cancer-by-regulating-epithelial-mesenchymal-transition-via-activating-pi3k-akt-mtor-pathway
#4
Yanli Li, Tingting Wu, Yanan Wang, Liu Yang, Chengcheng Hu, Limo Chen, Sufang Wu
OBJECTIVE: High grade serous ovarian cancer (HGSC) remains one of the most lethal malignancies in females. We previously reported that γ-glutamyl cyclotransferase (GGCT) was significantly upregulated in serous ovarian cancer. The current study was aimed to explore the function and underlying mechanism of GGCT in HGSC. METHODS: GGCT expression was assessed by immunohistochemistry in 128 HGSC patients. Stable cell lines with GGCT gene overexpression or knockdown were established to investigate the function of GGCT in HGSC in vitro and in vivo...
February 8, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29425345/recurrent-central-serous-retinopathy-with-permanent-visual-loss-in-a-u-s-naval-fighter-pilot
#5
Ryan R Richmond, Matthew Rings
Central serous retinopathy (CSR) is a disease process that involves accumulation of serous fluid within the macular retina. This fluid accumulation can temporarily or permanently disrupt vision and in many patients is often a recurrent problem. This case describes recurrent CSR in an experienced U.S. Naval F/A-18 fighter pilot. The patient had been troubled by recurrent CSR for several years which required him to be removed from a flying status. After several episodes and treatment with laser photocoagulation and finasteride, the patient's vision and disease process stabilized, but with permanent defective visual acuity in the right eye...
February 7, 2018: Military Medicine
https://www.readbyqxmd.com/read/29424884/clinical-research-on-one-third-dose-verteporfin-photodynamic-therapy-in-the-treatment-of-chronic-central-serous-chorioretinopathy
#6
L Hua, B Lin, J Hong, H-B Min, W-L Han, T-Y Zhou, Z-Q Zhang
OBJECTIVE: To observe the curative effect and safety of one-third dose Verteporfin photodynamic therapy (PDT) in the treatment of chronic central serous chorioretinopathy (CSC). PATIENTS AND METHODS: A total of 60 patients (68 eyes) treated in our hospital from January 2016 to December 2016 were selected in this study, and they were diagnosed with chronic CSC via fluorescein fundus angiography (FFA), indocyanine green angiography (ICGA) and optical coherence tomography (OCT)...
January 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29422860/chronic-central-serous-chorioretinopathy-like-maculopathy-as-atypical-presentation-of-chorioretinal-folds
#7
Tina Xirou, Stamatina A Kabanarou, Ilias Gkizis, Christina Garnavou-Xirou, Stavros Velissaris, Panagiotis Theodossiadis, Irini Chatziralli
Purpose: The purpose of this case report was to present the clinical data and management of a 69-year-old female patient with chorioretinal folds who developed chronic central serous chorioretinopathy-like maculopathy. Case Presentation: A 69-year-old female patient presented with a recent-onset slight decrease in visual acuity in her left eye. Her past ocular history was clear. Regarding her medical history, she had only hypertension, treated with per os medications...
September 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29409857/early-choriocapillaris-changes-after-half-fluence-photodynamic-therapy-in-chronic-central-serous-chorioretinopathy-evaluated-by-optical-coherence-tomography-angiography-preliminary-results
#8
Ali Demircan, Ceren Yesilkaya, Zeynep Alkin
BACKGROUND: The purpose of this study is to examine the choridal perfusion in patients with chronic central serous chorioretinopathy (CSC) after half-fluence photodynamic therapy (PDT) in the early post-treatment period. METHODS: This retrospective study included patients with chronic CSC. Indocyanine green angiography (ICGA) guided half-fluence PDT was applied to the all eyes. Best corrected visual acuity (BCVA) was assessed by Snellen chart and central retinal thickness (CRT) and subfoveal choroidal thickness (SFCT) was measured by spectral domain optical coherence tomography (SD-OCT) before PDT and at 3 and 30 days following the therapy...
February 1, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29396936/flow-cytometry-in-pediatric-malignancies
#9
Anil Handoo, Tina Dadu
The utility of flow cytometry as a useful diagnostic modality for the assessment of hematopoietic neoplasms has been established beyond doubt. In fact, it is now an integral part of the diagnosis and classification of various diseases like leukemias and lymphomas along with molecular studies and cytogenetics. Prognostication and disease monitoring by flow cytometry is also being recognized increasingly as one of the important fortes. This is evident by the number of articles in the published in literature on the minimal residual disease detection by flow cytometry especially in the last decade or so...
January 15, 2018: Indian Pediatrics
https://www.readbyqxmd.com/read/29380797/torpedo-maculopathy-with-multifocal-central-serous-chorioretinopathy-a-rare-case-report
#10
Pradeep Kumar Panigrahi, Anita Minj, Jasmita Satapathy
We present a very rare case of torpedo maculopathy (TM) with multifocal central serous chorioretinopathy. A 26-year-old male presented with painless loss of vision in the right eye of 2 months duration. Clinical examination showed a torpedo-shaped lesion temporal to fovea and subretinal fluid in foveal center. Fluorescein angiography showed multifocal leaks. Optical coherence tomography showed an optically clear space/neurosensory detachment at the site of lesion. Patient underwent focal laser to the leaks...
February 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29379166/aggressive-serous-epithelial-ovarian-cancer-is-potentially-propagated-by-epcam-cd45-phenotype
#11
Md Zahid Akhter, Surender K Sharawat, Vikash Kumar, Veena Kochat, Zaffar Equbal, Mallika Ramakrishnan, Umesh Kumar, Sandeep Mathur, Lalit Kumar, Asok Mukhopadhyay
Epithelial ovarian carcinoma (EOC) patients often acquire resistance against common chemotherapeutic drugs like paclitaxel and cisplatin. The mechanism responsible for the same is ambiguous. We have identified a putative drug-resistant tumour cell phenotype (EpCAM+CD45+) in the ascitic fluid of EOC patients, which appears to originate from the primary tumour. These cells represent the major tumour burden and are more drug resistant compared to EpCAM+tumour cells due to the over-expression of SIRT1, ABCA1 and BCL2 genes...
January 30, 2018: Oncogene
https://www.readbyqxmd.com/read/29374647/acute-retinal-detachment-induced-by-the-valsalva-manoeuvre-in-morning-glory-disc-anomaly
#12
Mark A P Fajgenbaum, Serafeim N Antonakis, Luke Membrey, David A Laidlaw
We present a case in which a large, bullous, predominantly inferior, serous retinal detachment developed acutely after the Valsalva manoeuvre (from a coughing fit) in an eye with morning glory disc anomaly. We postulate that a rapid alteration in intracranial pressure was transmitted through the cavitary disc defect. This allowed a sudden influx of cerebrospinal fluid and/or liquefied vitreous into the subretinal space. This previously unreported case provides important evidence for the role of intracranial pressure fluctuations in the pathogenesis of macular schisis and neurosensory detachment secondary to optic disc cavitations...
January 26, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29359109/proteome-and-metabolome-of-subretinal-fluid-in-central-serous-chorioretinopathy-and-rhegmatogenous-retinal-detachment-a-pilot-case-study
#13
Laura Kowalczuk, Alexandre Matet, Marianne Dor, Nasim Bararpour, Alejandra Daruich, Ali Dirani, Francine Behar-Cohen, Aurélien Thomas, Natacha Turck
Purpose: To investigate the molecular composition of subretinal fluid (SRF) in central serous chorioretinopathy (CSCR) and rhegmatogenous retinal detachment (RRD) using proteomics and metabolomics. Methods: SRF was obtained from one patient with severe nonresolving bullous CSCR requiring surgical subretinal fibrin removal, and two patients with long-standing RRD. Proteins were trypsin-digested, labeled with Tandem-Mass-Tag and fractionated according to their isoelectric point for identification and quantification by tandem mass spectrometry...
January 2018: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29355165/comparison-of-efficacy-of-cell-block-versus-conventional-smear-study-in-exudative-fluids
#14
Sandeep S Matreja, Kamal Malukani, Shirish S Nandedkar, Amit V Varma, Anjali Saxena, Arpita Ajmera
INTRODUCTION: Cytological examination of serous effusions helps in staging, prognostication and management of patients with malignancy. The method has disadvantage of lower sensitivity in differentiating reactive atypical mesothelial cells from malignant cells. AIM: The aim of this study is to compare the cytological features of pleural and peritoneal exudative fluids by conventional smear (CS) method and cell block (CB) method and also to assess the utility of a combined approach for cytodiagnosis of these effusions...
October 2017: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29338158/studying-the-serum-as-well-as-serous-level-of-il-17-and-il-23-in-patients-with-serous-otitis-media
#15
Ahmad Yeghaneh Moghaddam, Rezvan Talaei, Hassan Nikoueinejad, Hossein Akbari
Serous otitis media with effusion (OME) is a middle ear inflammatory response to allergens and microbes which stimulate leukocytes to produce different inflammatory mediators after obstruction of Eustachian tube. Here, we investigated the levels of these mediators, IL-17 and IL-23, in serum and middle ear fluids of children with OME. 75 patients with otitis media and 75 age and sex-matched healthy controls were enrolled in this study. IL-17 and IL-23 levels in serous secretion of the patients and their serum levels were measured in both groups by ELISA...
December 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29338133/pimasertib-associated-ophthalmological-adverse-events
#16
Elon H C van Dijk, Wim H J Kruit, Martine J Jager, Gregorius P M Luyten, Johannes R Vingerling, Camiel J F Boon
PURPOSE: To analyse ophthalmological adverse events associated with mitogen-activated protein kinase kinase (MEK) inhibition with pimasertib treatment for metastatic cutaneous melanoma (CM). METHODS: In this prospective observational, cohort-based, cross-sectional study, eight patients treated with the MEK inhibitor pimasertib received a complete ophthalmic examination. This included Early Treatment of Diabetic Retinopathy Study best-corrected visual acuity, visual field testing, colour vision testing, slit-lamp examination, applanation tonometry, indirect ophthalmoscopy, digital colour fundus photography and optical coherence tomography (OCT)...
January 16, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29338130/correlation-between-morphological-characteristics-in-spectral-domain-optical-coherence-tomography-different-functional-tests-and-a-patient-s-subjective-handicap-in-acute-central-serous-chorioretinopathy
#17
Bianca S Gerendas, Julia-Sophie Kroisamer, Wolf Buehl, Sandra M Rezar-Dreindl, Katharina M Eibenberger, Eleonore Pablik, Ursula Schmidt-Erfurth, Stefan Sacu
PURPOSE: The purpose of this study was to identify quantitatively measurable morphologic optical coherence tomography (OCT) characteristics in patients with an acute episode of central serous chorioretinopathy (CSC) and evaluate their correlation to functional and psychological variables for their use in daily clinical practice. METHODS: Retinal thickness (RT), the height, area and volume of subretinal fluid (SRF)/pigment epithelium detachments were evaluated using the standardized procedures of the Vienna Reading Center...
January 16, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29311408/hepatic-hydrothorax
#18
Yong Lv, Guohong Han, Daiming Fan
Hepatic hydrothorax (HH) is a pleural effusion that develops in a patient with cirrhosis and portal hypertension in the absence of cardiopulmonary disease. Although the development of HH remains incompletely understood, the most acceptable explanation is that the pleural effusion is a result of a direct passage of ascitic fluid into the pleural cavity through a defect in the diaphragm due to the raised abdominal pressure and the negative pressure within the pleural space. Patients with HH can be asymptomatic or present with pulmonary symptoms such as shortness of breath, cough, hypoxemia, or respiratory failure associated with large pleural effusions...
December 27, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/29303152/response-of-central-serous-chorioretinopathy-evaluated-by-multimodal-retinal-imaging
#19
R Sacconi, G Baldin, A Carnevali, L Querques, A Rabiolo, G Marchini, F Bandello, G Querques
PurposeTo identify predictive biomarkers of treatment outcomes by multimodal retinal imaging in patients affected by central serous chorioretinopathy (CSC).Patients and methodsIn this interventional non-randomized clinical study, 27 treatment-naive CSC patients were prospectively enrolled and treated with oral eplerenone for 5-13 weeks. Primary outcomes included presence of pathological findings on indocyaine green angiography (ICGA), structural optical coherence tomography (OCT) and OCT-angiography (OCT-A) at baseline associated with different response to the treatment...
January 5, 2018: Eye
https://www.readbyqxmd.com/read/29303148/visual-outcomes-and-anatomic-changes-after-sub-threshold-micropulse-yellow-laser-577-nm-treatment-for-chronic-central-serous-chorioretinopathy-long-term-follow-up
#20
A Arsan, H S Kanar, A Sonmez
PurposeTo analyze the long-term efficacy of 577 nm sub-threshold micropulse yellow laser (SMYL) in the treatment of chronic central serous chorioretinopathy (CCSC) and to evaluate the anatomic outcome, visual results and safety profile of the treatment.Patients and methodsThis prospective study assessed 39 eyes of 39 patients with non-resolving CCSC lasting more than three months. All eyes were treated by using 577 nm SMYL system with 5% duty cycle (DC) and each patients was monitored monthly. The main outcome measures were best-corrected visual acuity (BCVA), contrast sensitivity (CS) and subretinal fluid (SRF) height, central macular thickness (CMT), central macular volume (CMV), total macular volume (TMV), and subfoveal choroidal thickness (SFCT) measured by spectral domain optical coherence tomography (SD-OCT)...
January 5, 2018: Eye
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