Domenick A Prosdocimo, Priti Anand, Xudong Liao, Han Zhu, Shamanthika Shelkay, Pedro Artero-Calderon, Lilei Zhang, Jacob Kirsh, D'Vesharronne Moore, Mariana G Rosca, Edwin Vazquez, Janos Kerner, Kemal M Akat, Zev Williams, Jihe Zhao, Hisashi Fujioka, Thomas Tuschl, Xiaodong Bai, P Christian Schulze, Charles L Hoppel, Mukesh K Jain, Saptarsi M Haldar
The mammalian heart, the body's largest energy consumer, has evolved robust mechanisms to tightly couple fuel supply with energy demand across a wide range of physiologic and pathophysiologic states, yet, when compared with other organs, relatively little is known about the molecular machinery that directly governs metabolic plasticity in the heart. Although previous studies have defined Kruppel-like factor 15 (KLF15) as a transcriptional repressor of pathologic cardiac hypertrophy, a direct role for the KLF family in cardiac metabolism has not been previously established...
February 28, 2014: Journal of Biological Chemistry