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Hans Hoppeler

Raul K Suarez, Hans H Hoppeler
No abstract text is available yet for this article.
March 7, 2018: Journal of Experimental Biology
Michaela J P Handel, Hans H Hoppeler
No abstract text is available yet for this article.
January 8, 2018: Journal of Experimental Biology
Martino V Franchi, Kyle W Mitchell, Hans Hoppeler, Marco V Narici
No abstract text is available yet for this article.
2017: Frontiers in Physiology
Paola Valdivieso, Marco Toigo, Hans Hoppeler, Martin Flück
BACKGROUND: Mechanical stress, including blood pressure related factors, up-regulate expression of the pro-angiogenic extracellular matrix protein tenascin-C in skeletal muscle. We hypothesized that increased capillarization of skeletal muscle with the repeated augmentation in perfusion during endurance training is associated with blood vessel-related expression of tenascin-C and would be affected by the single-nucleotide polymorphism (SNP) rs2104772, which characterizes the non-synonymous exchange of thymidine (T)-to-adenosine (A) in the amino acid codon 1677 of tenascin-C...
2017: PloS One
Hans Hoppeler
Over the last 20 years a number of studies have been published using progressive eccentric exercise protocols on motorized ergometers or similar devices that allow for controlled application of eccentric loads. Exercise protocols ramp eccentric loads over an initial 3 weeks period in order to prevent muscle damage and delayed onset muscle soreness. Final training loads reach 400-500 W in rehabilitative settings and over 1200 W in elite athletes. Training is typically carried out three times per week for durations of 20-30 min...
2016: Frontiers in Physiology
Oliver Baum, Eleonora Torchetti, Corinna Malik, Birgitte Hoier, Meegan Walker, Philip J Walker, Adolfo Odriozola, Franziska Graber, Stefan A Tschanz, Jens Bangsbo, Hans Hoppeler, Christopher D Askew, Ylva Hellsten
Intermittent claudication (IC) is the most commonly reported symptom of peripheral arterial disease (PAD). Impaired limb blood flow is a major casual factor of lower exercise tolerance in PAD but cannot entirely explain it. We hypothesized that IC is associated with structural changes of the capillary-mitochondria interface that could contribute to the reduction of exercise tolerance in IC patients. Capillary and mitochondrial morphometry were performed after light and transmission electron microscopy using vastus lateralis muscle biopsies of 14 IC patients and 10 age-matched controls, and peak power output (PPO) was determined for all participants using an incremental single-leg knee-extension protocol...
May 15, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Hans Hoppeler
The skeletal muscle phenotype is subject to considerable malleability depending on use as well as internal and external cues. In humans, low-load endurance-type exercise leads to qualitative changes of muscle tissue characterized by an increase in structures supporting oxygen delivery and consumption, such as capillaries and mitochondria. High-load strength-type exercise leads to growth of muscle fibers dominated by an increase in contractile proteins. In endurance exercise, stress-induced signaling leads to transcriptional upregulation of genes, with Ca(2+) signaling and the energy status of the muscle cells sensed through AMPK being major input determinants...
January 2016: Journal of Experimental Biology
Stan L Lindstedt, Hans H Hoppeler
No abstract text is available yet for this article.
January 2016: Journal of Experimental Biology
Hans H Hoppeler, Michaela J P Handel, O Claire Moulton
No abstract text is available yet for this article.
November 2015: Journal of Experimental Biology
Oliver Baum, Jennifer Gübeli, Sebastian Frese, Eleonora Torchetti, Corinna Malik, Adolfo Odriozola, Franziska Graber, Hans Hoppeler, Stefan A Tschanz
The ultrastructure of capillaries in skeletal muscle was morphometrically assessed in vastus lateralis muscle (VL) biopsies taken before and after exercise from 22 participants of two training studies. In study 1 (8 wk of ergometer training), light microscopy revealed capillary-fiber (C/F) ratio (+27%) and capillary density (+16%) to be higher (P ≤ 0.05) in postexercise biopsies than in preexercise biopsies from all 10 participants. In study 2 (6 mo of moderate running), C/F ratio and capillary density were increased (+23% and +20%; respectively, P ≤ 0...
November 15, 2015: Journal of Applied Physiology
Tatiane Gorski, Thomas Rosser, Hans Hoppeler, Michael Vogt
PURPOSE: To verify whether relative age effects (RAEs) occur among young male and female Swiss Alpine skiers of different age groups and performance levels. In addition, the efficacy of normalizing performance in physical tests to height and body mass to attenuate RAEs eventually present was tested. METHODS: The Swiss Ski Power Test consists of anthropometric measures and physical tests for coordination and speed, endurance, and strength and has been used since 2004 to evaluate 11- to 19-y-old Swiss competitive Alpine skiers...
May 2016: International Journal of Sports Physiology and Performance
L Gliemann, R Buess, M Nyberg, H Hoppeler, A Odriozola, P Thaning, Y Hellsten, O Baum, S P Mortensen
AIM: The aim was to elucidate whether essential hypertension is associated with altered capillary morphology and density and to what extent exercise training can normalize these parameters. METHODS: To investigate angiogenesis and capillary morphology in essential hypertension, muscle biopsies were obtained from m. vastus lateralis in subjects with essential hypertension (n = 10) and normotensive controls (n = 11) before and after 8 weeks of aerobic exercise training...
June 2015: Acta Physiologica
Hans H Hoppeler
No abstract text is available yet for this article.
January 1, 2015: Journal of Experimental Biology
Hans H Hoppeler
No abstract text is available yet for this article.
November 1, 2014: Journal of Experimental Biology
Glenn J Lurman, Johanna Walter, Hans H Hoppeler
Temperature plays a critical role in determining the biology of ectotherms. Many animals have evolved mechanisms that allow them to compensate biological rates, i.e. adjust biological rates to overcome thermodynamic effects. For low energy-organisms, such as bivalves, the costs of thermal compensation may be greater than the benefits, and thus prohibitive. To examine this, two experiments were designed to explore thermal compensation in Unio tumidus. Experiment 1 examined seasonal changes in behaviour in U...
July 2014: Journal of Thermal Biology
Micah Gross, Kathrin Bieri, Hans Hoppeler, Barbara Norman, Michael Vogt
INTRODUCTION: Supplementation with beta-alanine may have positive effects on severe-intensity, intermittent, and isometric strength-endurance performance. These could be advantageous for competitive alpine skiers, whose races last 45 to 150 s, require metabolic power above the aerobic maximum, and involve isometric muscle work. Further, beta-alanine supplementation affects the muscle force-frequency relationship, which could influence explosiveness. We explored the effects of beta-alanine on explosive jump performance, severe exercise energy metabolism, and severe-intensity ski-like performance...
December 2014: International Journal of Sport Nutrition and Exercise Metabolism
Hans Hoppeler, Walter Herzog
No abstract text is available yet for this article.
June 1, 2014: Journal of Applied Physiology
Michael Vogt, Hans H Hoppeler
The aim of the current review is to discuss applications and mechanism of eccentric exercise in training regimes of competitive sports. Eccentric muscle work is important in most sports. Eccentric muscle contractions enhance the performance during the concentric phase of stretch-shortening cycles, which is important in disciplines like sprinting, jumping, throwing, and running. Muscles activated during lengthening movements can also function as shock absorbers, to decelerate during landing tasks or to precisely deal with high external loading in sports like alpine skiing...
June 1, 2014: Journal of Applied Physiology
Domenick A Prosdocimo, Priti Anand, Xudong Liao, Han Zhu, Shamanthika Shelkay, Pedro Artero-Calderon, Lilei Zhang, Jacob Kirsh, D'Vesharronne Moore, Mariana G Rosca, Edwin Vazquez, Janos Kerner, Kemal M Akat, Zev Williams, Jihe Zhao, Hisashi Fujioka, Thomas Tuschl, Xiaodong Bai, P Christian Schulze, Charles L Hoppel, Mukesh K Jain, Saptarsi M Haldar
The mammalian heart, the body's largest energy consumer, has evolved robust mechanisms to tightly couple fuel supply with energy demand across a wide range of physiologic and pathophysiologic states, yet, when compared with other organs, relatively little is known about the molecular machinery that directly governs metabolic plasticity in the heart. Although previous studies have defined Kruppel-like factor 15 (KLF15) as a transcriptional repressor of pathologic cardiac hypertrophy, a direct role for the KLF family in cardiac metabolism has not been previously established...
February 28, 2014: Journal of Biological Chemistry
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