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L Chen, J-Q Jiang, Y Zhang, H Feng
OBJECTIVE: As an initial step in exploring the feasibility of oral sulfhydryl as an adjuvant for improving nitrate ester tolerance, this study was designed to experimentally test the adjuvant therapy in a rabbit model of atherosclerosis (AS). MATERIALS AND METHODS: New Zealand white rabbits with induced AS were randomly divided into four groups: AS group, AS + nitrate ester group, AS + nitrate ester tolerance group, and AS + drug combination group. Additionally, four equivalent groups with healthy New Zealand white rabbits without AS were also conformed...
March 2018: European Review for Medical and Pharmacological Sciences
Neeladri Sekhar Roy, Subrata Debnath, Abhijit Chakraborty, Prasenjit Chakraborty, Indrani Bera, Raka Ghosh, Nanda Ghoshal, Saikat Chakrabarti, Siddhartha Roy
Localized separation of strands of duplex DNA is a necessary step in many DNA-dependent processes, including transcription and replication. Little is known about how these strand separations occur. The strand-separated E.coli RNA polymerase-promoter open-complex structure showed four bases of the non-template strand, the master base -11A, -7, -6 and +2, in a flipped state and inserted into protein pockets. To explore whether any property of these bases in the duplex state pre-disposes them to flipping, NMR studies were performed on a wild-type promoter in the duplex state...
March 22, 2018: Physical Chemistry Chemical Physics: PCCP
Mohammad Asadi, Baharak Sayahpour, Pedram Abbasi, Anh T Ngo, Klas Karis, Jacob R Jokisaari, Cong Liu, Badri Narayanan, Marc Gerard, Poya Yasaei, Xuan Hu, Arijita Mukherjee, Kah Chun Lau, Rajeev S Assary, Fatemeh Khalili-Araghi, Robert F Klie, Larry A Curtiss, Amin Salehi-Khojin
Lithium-air batteries are considered to be a potential alternative to lithium-ion batteries for transportation applications, owing to their high theoretical specific energy. So far, however, such systems have been largely restricted to pure oxygen environments (lithium-oxygen batteries) and have a limited cycle life owing to side reactions involving the cathode, anode and electrolyte. In the presence of nitrogen, carbon dioxide and water vapour, these side reactions can become even more complex. Moreover, because of the need to store oxygen, the volumetric energy densities of lithium-oxygen systems may be too small for practical applications...
March 21, 2018: Nature
Hiroyuki Yanagisawa, Yukihiko Kudo, Katsuhiro Nakagawa, Haruhiko Miyagawa, Fumitaka Maruyama, Shigehiko Fujimaki
This study was conducted with the aim of achieving the simultaneous screening of various additives in polymer materials by utilizing a solvent-free pyrolyzer/thermal desorption gas chromatography mass spectrometry (Py/TD-GC-MS) method. As a first step to achieve this goal, simultaneous screening has been examined by selecting major substances representing plasticizers and flame retardants, such as short chain chlorinated paraffins (SCCPs), decabromodiphenyl ether (DecaBDE), hexabromocyclododecane (HBCDD), and di(2-ethylhexyl) phthalate (DEHP)...
March 22, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Mingyang Shang, Bing Han, Chibiao Ding, Jili Sun, Tao Zhang, Lijia Huang, Dadi Meng
Spotlight synthetic aperture radar (SAR) is a proven technique, which can provide high-resolution images as compared to those produced by traditional stripmap SAR. This paper addresses a high-resolution SAR focusing experiment based on Gaofen-3 satellite (GF-3) staring data with about 55 cm azimuth resolution and 240 MHz range bandwidth. In staring spotlight (ST) mode, the antenna always illuminates the same scene on the ground, which can extend the synthetic aperture. Based on a two-step processing algorithm, some special aspects such as curved-orbit model error correction, stop-and-go correction, and antenna pattern demodulation must be considered in image focusing...
March 22, 2018: Sensors
Jiaquan Yan, Haixin Sun, Hailan Chen, Naveed Ur Rehman Junejo, En Cheng
In this paper, a novel time-frequency signature using resonance-based sparse signal decomposition (RSSD), phase space reconstruction (PSR), time-frequency distribution (TFD) and manifold learning is proposed for feature extraction of ship-radiated noise, which is called resonance-based time-frequency manifold (RTFM). This is suitable for analyzing signals with oscillatory, non-stationary and non-linear characteristics in a situation of serious noise pollution. Unlike the traditional methods which are sensitive to noise and just consider one side of oscillatory, non-stationary and non-linear characteristics, the proposed RTFM can provide the intact feature signature of all these characteristics in the form of a time-frequency signature by the following steps: first, RSSD is employed on the raw signal to extract the high-oscillatory component and abandon the low-oscillatory component...
March 22, 2018: Sensors
Elena Khazina, Oliver Weichenrieder
LINE-1 (L1) is an autonomous retrotransposon, which acted throughout mammalian evolution and keeps contributing to human genotypic diversity, genetic disease and cancer. L1 encodes two essential proteins: L1ORF1p, a unique RNA-binding protein, and L1ORF2p, an endonuclease and reverse transcriptase. L1ORF1p contains an essential, but rapidly evolving N-terminal portion, homo-trimerizes via a coiled coil and packages L1RNA into large assemblies. Here, we determined crystal structures of the entire coiled coil domain of human L1ORF1p...
March 22, 2018: ELife
Carmen Gallego Fernández
No abstract text is available yet for this article.
January 25, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Xiaobin Mo, Timothy D R Morgan, Hwee Ting Ang, Dennis G Hall
Catalytic activation of hydroxyl functionalities is of great interest for the production of pharmaceuticals and commodity chemicals. Here, 2-alkoxycarbonyl- and 2-phenoxycarbonyl-phenylboronic acid were identified as efficient catalysts for the direct and chemoselective activation of oxime N-OH bonds in the Beckmann rearrangement. This classical organic reaction provides a unique approach to prepare functionalized amide products that may be difficult to access using traditional amide coupling between carboxylic acids and amines...
March 22, 2018: Journal of the American Chemical Society
Kai Wang, Xiaoguang Xu, Liying Lu, Haicheng Wang, Yan Li, Yong Wu, Jun Miao, Jin Z Zhang, Yong Jiang
Ag/Bi2 Fe4 O9 nanoparticles (BFO NPs) have been synthesized using a two step approach involving glycine combustion and visible light irradiation. Their structures were characterized in detail using XRD, TEM, SEM, and STEM techniques. Their electrocatalytic properties were studied through enzymatic glucose detection with an amperometric biosensor. The Ag deposited on selective crystal facets of BFO NPs significantly enhanced their electrocatalytic activity. To gain insight into the origin of the enhanced electrocatalytic activities, we have carried out studies of Ag+ reduction and Mn2+ oxidation reaction at {200} and {001} facets, respectively...
March 22, 2018: ACS Applied Materials & Interfaces
Songcheng Wang, Yi Zhang, J Carson Meredith, Sven H Behrens, Manoj Kumar Tripathi, Kirti Chandra Sahu
Air bubbles rising through an aqueous medium have been studied extensively and are routinely used for the separation of particulates via froth flotation, a key step in many industrial processes. Oil-coated bubbles can be more effective for separating hydrophilic particles with low affinity for the air-water interface, but the rise dynamics of oil-coated bubbles has not yet been explored. In the present work, we report the first systematic study of the shape and rise trajectory of bubbles engulfed in a layer of oil...
March 22, 2018: Soft Matter
Paolo Cornaglia Ferraris
Humans are influenced by irrational preferences in making choices, so that clinicians also are prone to irrational decision-making. Exhaustive information about the value of therapies are frequently unavailable, full results of intervention trials are often hidden, conclusive evidence is highly desirable but it is seldom accessible. Healthcare could benefit from the new ways of approaching the decision framework due to behavioral economists: understanding the hidden traps in decision-making and the way the human brain works is an essential step and the best protection from biases is always awareness...
March 2018: Recenti Progressi in Medicina
Michalina Błażkiewicz, Ida Wiszomirska, Katarzyna Kaczmarczyk, Andrzej Wit
BACKGROUND: Falls constitute an important health issue. They cause significant morbidity, mortality and have marked psychological effects on the individual, too. The aim of this study has been to determine parameters describing human movement strategies for balance and the reaction if balance is lost as a result of an unstable ground, and to attempt to describe the types of falls. MATERIAL AND METHODS: The study group comprised 20 volunteers. Kinematic parameters of falling and dynamic stability were measured using the Vicon Motion System and the Biodex Balance System SD...
March 15, 2018: Medycyna Pracy
Ladislav Kabelka
Geriatric palliative care must be based on quality geriatric medicine. This applies in particular the multidisciplinary care of patients with geriatric frailty syndrome, most often associated with the polymorbidity of chronic diseases. The model of early indication of the needs of fragile geriatric patients is not more widely available in the current Czech health and social system. Therefore, the necessary early indication of specialized palliative care is not available in hospital facilities. Regional models of conceptual solutions are a necessary next step in development...
2018: Casopís Lékar̆ů C̆eských
Jia-Li Liu, Zhi-Ling Tang, Jia-Qi Zhang, Yaqin Chai, Ying Zhuo, Ruo Yuan
The electrochemiluminescence (ECL) properties of polycyclic aromatic hydrocarbons (PAHs) are excellent on account of the high photoluminescence quantum yield. However, the poor solubility and radical instability of PAHs in the aqueous solution severely restricted the further biological application. Here, 9,10 - diphenylanthracene (DPA) nano blocks (NBs) with good dispersibility and stability in aqueous solution were prepared according to morphology-controlled technology employing water-soluble polymers as a protectant...
March 22, 2018: Analytical Chemistry
Fernando González-Mohíno, Raúl Martín, Daniel Juárez Santos-García, Pedro Angel Fidel, Francisco de Asis Fernandez, Inmaculada Yustres, José María González Ravé
The objective of this study was to determine the effects of high-intensity warm-ups (WUs) on performance, physiological, neuromuscular and biomechanical parameters. Three randomized cross-over 105%vVO2 max time limit trials (TLimT) were performed by 11 well-trained runners following three different WU protocols. These included two experimental high-intensity variants and one control WU variant: (i) 9x20-sec level strides (105%vVO2 max; 1% gradient) with 60 s of recovery (level); (ii) 6x6-sec uphill strides (105%vVO2 max; 5% gradient), with the same recovery (uphill) and (iii) 7 min at 60%vVO2 max as control condition (control)...
March 21, 2018: International Journal of Sports Medicine
Brittany L Daughtry, Shawn L Chavez
The use of time-lapse microscopic imaging has proven to be a powerful tool for the study of mitotic divisions and other cellular processes across diverse species and cell types. Although time-lapse monitoring (TLM) of human preimplantation development was first introduced to the in vitro fertilization (IVF) community several decades ago, it was not until relatively recently that TLM systems were commercialized for clinical embryology purposes. Traditionally, human IVF embryos are assessed by successful progression and morphology under a stereomicroscope at distinct time points prior to selection for transfer...
2018: Methods in Molecular Biology
Veronica Ortega, Christina Mendiola, Gopalrao V N Velagaleti
One of the well-known hallmarks of cancer is genomic instability. Although gradualism is a well-established process of cancer evolution, recent studies have shown that chromothripsis or chromoanasynthesis can result in complex genomic rearrangements by a single catastrophic event rather than several incremental steps. These two novel phenomena suggest an evolutionary modality for cancer cells to circumvent individual mutational events with one simultaneous shattering of chromosomes or chromosome regions resulting in the random reassembling of shattered genetic material to form complex derivative chromosomes...
2018: Methods in Molecular Biology
Johan Pahlberg, Anurima Majumder, Nikolai O Artemyev
Mice have been widely used as a model organism to study mechanisms of phototransduction and synaptic transmission in the retina. Genetic manipulations and electrophysiological techniques for analysis of photoreceptor and rod bipolar cell function in mice are uniquely advanced. Here, we describe a set of biochemical and electrophysiological techniques for evaluation of synaptic transmission at the rod-rod bipolar cell synapse, which represents the first and key step in the processing of dim-light visual information...
2018: Methods in Molecular Biology
Kazuko Koshiba-Takeuchi
In situ hybridization is defined as one of the most useful and powerful methods to know where genes (e.g., mRNA, ncRNA) of interest are expressed in tissues. Expression of mRNA can be detected as blue or dark purple signals though hybridization, immunoreaction and coloring steps. Genome-wide approaches in various model animals have been conducted thoroughly, and have led to new research areas aimed at uncovering novel gene functions in cell differentiation and development. To elucidate gene function, spatiotemporal gene expression analysis is very important...
2018: Methods in Molecular Biology
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