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JOURNAL ARTICLE
Andrea Horváth, Áron Tormássi, Szofia Hajósi-Kalcakosz, Annamária Huber, Judit Sahin-Tóth, Orsolya Dobay
Staphylococcus aureus is one of the most important human pathogenic bacteria and environmental surfaces play an important role in the spread of the bacterium. Presence of S. aureus on children's playgrounds and on toys was described in international studies, however, little is known about the prevalence and characteristics of S. aureus at playgrounds in Europe. In this study, 355 samples were collected from playgrounds from 16 cities in Hungary. Antibiotic susceptibility of the isolates was tested for nine antibiotics...
May 1, 2024: Scientific Reports
#22
JOURNAL ARTICLE
Sho Ishigaki, Nobuhiko Kajio, Noritada Yoshikawa, Hiroaki Taguchi
Tumor necrosis factor inhibitors are effective and recommended in treating patients with coexisting spondyloarthritis (SpA) and ulcerative colitis (UC); however, the evidence of their superiority over other drugs is insufficient.1 Although Janus kinase inhibitors (JAKi) have shown effectiveness in treating UC and psoriatic arthritis, there are no reports of treating coexisting SpA and UC with JAKi monotherapy.
May 1, 2024: Journal of Rheumatology
#23
REVIEW
Mariana Ivanova, Olena Zimba, Ivan Dimitrov, Alexander K Angelov, Tsvetoslav Georgiev
Axial Spondyloarthritis (axSpA) is a chronic, inflammatory, immune-mediated rheumatic disease that comprises two subsets, non-radiographic and radiographic axSpA, and belongs to a heterogeneous group of spondyloarthritides (SpA). Over the years, the concept of SpA has evolved significantly, as reflected in the existing classification criteria. Considerable progress has been made in understanding the genetic and immunological basis of axSpA, in studying the processes of chronic inflammation and pathological new bone formation, which are pathognomonic for the disease...
April 30, 2024: Rheumatology International
#24
JOURNAL ARTICLE
Gaurang N Algotar, Viral N Chauhan, Sanjay J Mehta
Background This study uses the Dundee Ready Educational Environment Measure (DREEM) questionnaire to investigate undergraduate medical students' perceptions regarding their educational environment. The study recognizes the pivotal role of the educational environment in shaping future healthcare professionals and aims to contribute valuable insights for continuous improvement. The DREEM questionnaire, a validated tool, provides a structured approach to assess various dimensions of the educational environment...
March 2024: Curēus
#25
JOURNAL ARTICLE
Consuelo Romero-Sánchez, Carlos Ferrer-Santos, Deisy Abril, Eduin Acosta-Hernández, Juliette De Ávila, Alejandro Ramos-Casallas, Javier Escobar, Wilson Bautista-Molano, Diego Jaimes, Adriana Beltrán-Ostos, Juan Manuel Bello-Gualtero, Cristian Flórez-Sarmiento, Viviana Parra-Izquierdo, Omar Javier Calixto
OBJECTIVE: To compare the diversity and composition of the gastrointestinal microbiome of patients with SpA. METHODS: MiSeq sequencing of the V3-V4 region of the 16S ribosomal RNA gene was performed on DNA isolated from stool. Patients with concurrent SpA and IBD were excluded. Differences were assessed for richness and diversity indices by QIIME 2™. Differences between means >0,2% with a p-value<0,05 were assumed significant. Institutional Ethics Committee endorsement...
February 1, 2024: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
#26
JOURNAL ARTICLE
Maria Alejandra Meneses-Toro, Omar Javier Calixto, Viviana Parra-Izquierdo, Cristian Flórez-Sarmiento, Juliette de Ávila de-Quiroga, Alejandro Ramos-Casallas, Lorena Chila-Moreno, Juan Manuel Bello-Gualtero, Wilson Bautista-Molano, Consuelo Romero-Sanchez
OBJECTIVE: This study aimed to establish the association between HLA-A, B, DR genotypes and gastrointestinal variables in patients with SpA without inflammatory bowel disease (IBD). METHODS: Retrospective study of 91 patients with SpA and 401 healthy controls, with typing by Illumina Sequencing/PacBio and LIFECODES HLA-PCR/SSO multiplex sequencing technology. The presence of gastrointestinal symptoms was evaluated by administering a survey, and those who presented 2 or more symptoms were taken for clinical evaluation by rheumatology and gastroenterology, colonoscopy and histopathological study...
February 1, 2024: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
#27
JOURNAL ARTICLE
Dumitru Mihăilă, Petruț-Ionel Bistricean, Răzvan-Ovidiu Gaceu, Elena-Maria Emandi, Emilian-Viorel Mihăilă, Vasilică-Dănuț Horodnic
The study analyzes with priority the bioclimatic conditions for tourist activities in two famous tourist areas in western Romania [(Băile Felix-Băile 1 Mai (BF_1 M) - Stâna de Vale - Vlădeasa and, respectively Băile Herculane (BH) - Semenic], from the perspective of the potential of health tourism and in the subsidiary of sports and camping tourism. Such researches are missing for western Romania. The main working tools in the evaluation of the tourist valences of the bioclimate include: the spatio-temporal analysis of the Physiologically Equivalent Temperature (PET) bioclimatic index, of the TCI climate-tourism index and of the climate-tourism schemes (CTIS)...
April 30, 2024: Heliyon
#28
REVIEW
Mahi Basra, Hemangi Patel, Alexandria Sobczak, Jordan Ditchek, Alejandro Biglione, Marc M Kesselman, Alessandra Posey
Spondyloarthropathy (SpA) is one of the most common causes of low back pain. It is caused by inflammatory arthritis in the spine, manifesting in various forms such as psoriatic arthritis (PsA), ankylosing spondylitis (AS), and sacroiliitis. A comprehensive systematic literature search was done to evaluate and compare MRI, CT, single-photon emission CT, PET, ultrasound (US) imaging, low-dose CT, and diffusion-weighted imaging (DWI) techniques in assessing SpAs. The search strategy was constructed by an analysis of key terms from relevant articles in MEDLINE ProQuest, Embase, and PubMed...
March 2024: Curēus
#29
JOURNAL ARTICLE
Vitor Hugo Balasco Serrão, Karine Minari, Humberto D'Muniz Pereira, Otavio Henrique Thiemann
The 21st amino acid, selenocysteine (Sec), is synthesized on its dedicated transfer RNA (tRNASec ). In bacteria, Sec is synthesized from Ser-tRNA[Ser]Sec by Selenocysteine Synthase (SelA), which is a pivotal enzyme in the biosynthesis of Sec. The structural characterization of bacterial SelA is of paramount importance to decipher its catalytic mechanism and its role in the regulation of the Sec-synthesis pathway. Here, we present a comprehensive single-particle cryo-electron microscopy (SPA cryoEM) structure of the bacterial SelA with an overall resolution of 2...
2024: Current research in structural biology
#30
JOURNAL ARTICLE
Alicia García-Dorta, Enrique González-Dávila, Marta Sánchez-Jareño, Luis Cea-Calvo, Manuel Pombo-Suárez, Fernando Sánchez-Alonso, Isabel Castrejón, Federico Díaz-González
BACKGROUND: The early identification of patients' profiles most likely to respond to and maintain long-term therapy with a biological drug can have clinical and cost-effectiveness implications. OBJECTIVES: To evaluate the utility of an innovative approach for early identification of patient profiles associated with long-term persistence of golimumab, a tumour necrosis factor inhibitor, in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), and axial spondyloarthritis (SpA) under real-world conditions...
2024: Frontiers in Immunology
#31
JOURNAL ARTICLE
Hongkun Ouyang, Lingling Tang, Jinglong Ma, Tao Pang
Sugar content is an essential indicator for evaluating crisp pear quality and categorization, being used for fruit quality identification and market sales prediction. In this study, we paired a support vector machine (SVM) algorithm with genetic algorithm optimization to reliably estimate the sugar content in crisp pears. We evaluated the spectral data and actual sugar content in crisp pears, then applied three preprocessing methods to the spectral data: standard normal variable transformation (SNV), multivariate scattering correction (MSC), and convolution smoothing (SG)...
April 22, 2024: Plants (Basel, Switzerland)
#32
JOURNAL ARTICLE
Jiyoul Yang, Hyun-A Jang, Hyunjeong Cho, Yo Han Im, Ji Hyoun Kim
Background and Objectives : Tuberculosis is caused by Mycobacterium tuberculosis (MTB), while nontuberculous mycobacteria (NTM) encompass a group of mycobacterial species that are distinct from the MTB complex and leprae. Spondyloarthritis (SpA) is a group of chronic inflammatory diseases with shared clinical characteristics and is treated with biological agents; however, their use may elevate the risk of MTB and NTM infections. This study aimed to compare the incidence and risk of MTB and NTM infections in patients with SpA, including ankylosing spondylitis (AS) and psoriatic arthritis (PsA), using a population-based approach...
March 31, 2024: Medicina
#33
JOURNAL ARTICLE
The Long-Acting Serine Protease Inhibitor mPEG-SPA-MDSPI16 Alleviates LPS-Induced Acute Lung Injury.
Jingrui Chen, Xinjun Zhou, Nan Dai, Xiaoyu Liu, Shihan Liu, Haipeng Zhang, Lingcong Kong, Hongxia Ma
Anti-inflammatory drugs have become the second-largest class of common drugs after anti-infective drugs in animal clinical care worldwide and are often combined with other drugs to treat fever and viral diseases caused by various factors. In our previous study, a novel serine protease inhibitor-encoding gene ( MDSPI16 ) with improved anti-inflammatory activity was selected from a constructed suppressive subducted hybridization library of housefly larvae. This protein could easily induce an immune response in animals and had a short half-life, which limited its wide application in the clinic...
April 22, 2024: International Journal of Molecular Sciences
#34
REVIEW
Maria Consiglia Bragazzi, Federica Pianigiani, Rosanna Venere, Lorenzo Ridola
The association between Inflammatory Bowel Disease (IBD) and Spondyloarthritis (SpA) has been known for years, as has the concept that IBD is associated with an altered intestinal bacterial composition, a condition known as "dysbiosis". Recently, a state of intestinal dysbiosis has also been found in SpA. Dysbiosis in the field of IBD has been well characterized so far, as well as in SpA. The aim of this review is to summarize what is known to date and to emphasize the similarities between the microbiota conditions in these two diseases: particularly, an altered distribution in the gut of Enterobacteriaceae , Streptococcus , Haemophilus , Clostridium , Akkermansia , Ruminococcus , Faecalibacterium Prausnitzii , Bacteroides Vulgatus , Dialister Invisus , and Bifidubacterium Adolescentis is common to both IBD and SpA...
April 12, 2024: Journal of Clinical Medicine
#35
MULTICENTER STUDY
Gustavo Gomes Resende, Carla Goncalves Schahin Saad, Claudia Diniz Lopes Marques, Sandra Lúcia Euzébio Ribeiro, Maria Bernadete Renoldi de Oliveira Gavi, Michel Alexandre Yazbek, Adriana de Oliveira Marinho, Rita de Cássia Menin, Manuella Lima Gomes Ochtrop, Andressa Miozzo Soares, Nara Gualberto Cavalcanti, Jamille Nascimento Carneiro, Glaucio Ricardo Werner de Castro, José Mauro Carneiro Fernandes, Elziane da Cruz Ribeiro E Souza, Corina Quental de Menezes Alvarenga, Rejane Maria Rodrigues de Abreu Vieira, Natalia Pereira Machado, Antônio Carlos Ximenes, Morgana Ohira Gazzeta, Cleandro Pires de Albuquerque, Thelma Larocca Skare, Mauro Waldemar Keiserman, Charles Lubianca Kohem, Gabriel Sarkis Benacon, Vítor Florêncio Santos Rocha, Ricardo da Cruz Lage, Olivio Brito Malheiro, Rywka Tenenbaum Medeiros Golebiovski, Thauana Luiza Oliveira, Ruben Horst Duque, Ana Carolina Londe, Marcelo de Medeiros Pinheiro, Percival Degrava Sampaio-Barros
BACKGROUND: There is a remarkable variability in the frequency of HLA-B27 positivity in patients with spondyloarthritis (SpA), which may be associated with different clinical presentations worldwide. However, there is a lack of data considering ethnicity and sex on the evaluation of the main clinical and prognostic outcomes in mixed-race populations. The aim of this study was to evaluate the frequency of HLA-B27 and its correlation with disease parameters in a large population of patients from the Brazilian Registry of Spondyloarthritis (RBE)...
April 26, 2024: Advances in Rheumatology
#36
REVIEW
Benjaman To, Ningyu Chai, Colin Fitzpatrick, Daniel Richardson
BACKGROUND: Cryptosporidium parasites are an important cause of diarrhoea globally and sexual transmission may occur in men who have sex with men (MSM). We aimed to systematically review the literature to explore any factors associated with transmission of Cryptosporidium in MSM to provide insight for future guidelines and public health strategies. METHODS: We searched MEDLINE, Embase, CINAHL and Web of Science for manuscripts published up to July 2023. A primary author conducted an initial screen of abstracts and full text eligibility, and risk of bias was assessed independently by two authors using the Joanna Briggs Institute critical appraisal tools...
April 26, 2024: International Journal of STD & AIDS
#37
Matthew D Turner, Steven Sandelich, Catherine Marco
Subperiosteal abscess (SPA) is a rare complication of acute sinusitis in children that may develop rapidly. In this case report, we describe an 11 year-old boy who presented with a large SPA 2 days after being diagnosed with conjunctivitis. The patient required emergent lateral canthotomy and cantholysis (LCC), IV antibiotics, and emergent surgery. It is crucial that emergency physicians be able to identify and treat this vision-threatening complication.
April 21, 2024: American Journal of Emergency Medicine
#38
JOURNAL ARTICLE
Anna M Stadelman-Behar, Mika N Gehre, Liana Atallah, Tegan Clarke, Ana-Alicia Leonso, Francella Jojola, HaoQiang Zheng, Hongwei Jia, Sheryl B Lyss, William M Switzer, Scott P Grytdal, Miranda Durham, N Mariam Salas, Marla Sievers, Chad Smelser
HIV transmitted through cosmetic injection services via contaminated blood has not been previously documented. During summer 2018, the New Mexico Department of Health (NMDOH) was notified of a diagnosis of HIV infection in a woman with no known HIV risk factors who reported exposure to needles from cosmetic platelet-rich plasma microneedling facials (vampire facials) received at a spa in spring 2018. An investigation of the spa's services began in summer 2018, and NMDOH and CDC identified four former spa clients, and one sexual partner of a spa client, all of whom received HIV infection diagnoses during 2018-2023, despite low reported behavioral risks associated with HIV acquisition...
April 25, 2024: MMWR. Morbidity and Mortality Weekly Report
#39
JOURNAL ARTICLE
Hui-Hsien Chang, Lin-Chen Huang, Karen S Browning, Enamul Huq, Mei-Chun Cheng
Light triggers an enhancement of global translation during photomorphogenesis in Arabidopsis, but little is known about the underlying mechanisms. The phosphorylation of the α-subunit of eukaryotic initiation factor 2 (eIF2α) at a conserved serine residue in the N-terminus has been shown as an important mechanism for the regulation of protein synthesis in mammalian and yeast cells. However, whether the phosphorylation of this residue in plant eIF2α plays a role in regulation of translation remains elusive...
April 24, 2024: Nature Communications
#40
MULTICENTER STUDY
Siyer Roohani, Felix Ehret, Marcus Beck, Danai P Veltsista, Jacek Nadobny, Sebastian Zschaeck, Sultan Abdel-Rahman, Franziska Eckert, Anne Flörcken, Rolf D Issels, Stephan Klöck, Robert Krempien, Lars H Lindner, Markus Notter, Oliver J Ott, Daniel Pink, Vlatko Potkrajcic, Peter Reichardt, Oliver Riesterer, Mateusz Jacek Spałek, Emanuel Stutz, Rüdiger Wessalowski, Thomas Zilli, Daniel Zips, Pirus Ghadjar, David Kaul
PURPOSE: To analyze the current practice of regional hyperthermia (RHT) for soft tissue sarcoma (STS) at 12 European centers to provide an overview, find consensuses and identify controversies necessary for future guidelines and clinical trials. METHODS: In this cross-sectional survey study, a 27-item questionnaire assessing clinical subjects and procedural details on RHT for STS was distributed to 12 European cancer centers for RHT. RESULTS: We have identified seven controversies and five consensus points...
2024: International Journal of Hyperthermia
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