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https://www.readbyqxmd.com/read/29079737/mir-1199-5p-and-zeb1-function-in-a-double-negative-feedback-loop-potentially-coordinating-emt-and-tumour-metastasis
#1
Maren Diepenbruck, Stefanie Tiede, Meera Saxena, Robert Ivanek, Ravi Kiran Reddy Kalathur, Fabiana Lüönd, Nathalie Meyer-Schaller, Gerhard Christofori
Epithelial tumour cells can gain invasive and metastatic capabilities by undergoing an epithelial-mesenchymal transition. Transcriptional regulators and post-transcriptional effectors like microRNAs orchestrate this process of high cellular plasticity and its malignant consequences. Here, using microRNA sequencing in a time-resolved manner and functional validation, we have identified microRNAs that are critical for the regulation of an epithelial-mesenchymal transition and of mesenchymal tumour cell migration...
October 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/28993127/retrospective-cohort-study-of-combined-approach-for-trunk-reconstruction-using-arteriovenous-loops-and-free-flaps
#2
Andreas Arkudas, Raymund E Horch, Susanne Regus, Alexander Meyer, Werner Lang, Marweh Schmitz, Anja M Boos, Ingo Ludolph, Justus P Beier
Defect reconstruction of the trunk can be performed using microsurgical free flap transplantation. In cases of missing or inappropriate recipient vessels, microsurgical defect reconstruction of the trunk can be achieved by combining free flaps with arteriovenous loops. Here we present our 5-year experience of trunk reconstruction using AV loops and free flaps in a retrospective evaluation. We analyzed 32 cases of trunk reconstruction using a combined approach of free flap transplantation and arteriovenous loops between 2011 and 2016 regarding postoperative complications and perioperative course...
September 13, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28931059/whole-genome-sequencing-of-mutants-with-increased-resistance-against-the-two-peptide-bacteriocin-plantaricin-jk-reveals-a-putative-receptor-and-potential-docking-site
#3
Bie Ekblad, Jon Nissen-Meyer, Tom Kristensen
By whole-genome sequencing of resistant mutants, a putative receptor for plantaricin JK, a two-peptide bacteriocin produced by some Lactobacillus plantarum strains, was identified in Lactobacillus plantarum NCFB 965 and Weissella viridescens NCFB 1655. The receptors of the two species had 66% identical amino acid sequences and belong to the amino acid-polyamine-organocation (APC) transporter protein family. The resistant mutants contained point mutations in the protein-encoding gene resulting in either premature stop codons, leading to truncated versions of the protein, or single amino acid substitutions...
2017: PloS One
https://www.readbyqxmd.com/read/28914759/isoform-sequencing-provides-a-more-comprehensive-view-of-the-panax-ginseng-transcriptome
#4
Ick-Hyun Jo, Jinsu Lee, Chi Eun Hong, Dong Jin Lee, Wonsil Bae, Sin-Gi Park, Yong Ju Ahn, Young Chang Kim, Jang Uk Kim, Jung Woo Lee, Dong Yun Hyun, Sung-Keun Rhee, Chang Pyo Hong, Kyong Hwan Bang, Hojin Ryu
Korean ginseng (Panax ginseng C.A. Meyer) has been widely used for medicinal purposes and contains potent plant secondary metabolites, including ginsenosides. To obtain transcriptomic data that offers a more comprehensive view of functional genomics in P. ginseng, we generated genome-wide transcriptome data from four different P. ginseng tissues using PacBio isoform sequencing (Iso-Seq) technology. A total of 135,317 assembled transcripts were generated with an average length of 3.2 kb and high assembly completeness...
September 15, 2017: Genes
https://www.readbyqxmd.com/read/28873070/functional-assessment-of-genetic-variants-located-in-the-promoter-of-shp1-nr0b2
#5
Katharina Prestin, Maria Olbert, Janine Hussner, Henry Völzke, Henriette E Meyer Zu Schwabedissen
Small heterodimer partner 1 (SHP1, NR0B2) is a member of the superfamily of nuclear receptors (NRs). Even if this orphan receptor, unlike other NRs, lacks the DNA-binding domain, it is capable of regulating transcription by repressing the activity of other NRs by direct protein-protein interaction. Accordingly, SHP1 is part of negative feedback loops of the transcriptional regulation of genes involved in drug metabolism and various metabolic pathways including bile acid and glucose homeostasis. Although it is known that several interacting partners of SHP1 also modulate its expression, there is little information about genetic variability of this regulatory mechanism...
November 2017: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/28860987/apathy-in-patients-with-parkinson-s-disease-correlates-with-alteration-of-left-fronto-polar-electroencephalographic-connectivity
#6
Florian Hatz, Antonia Meyer, Ronan Zimmermann, Ute Gschwandtner, Peter Fuhr
Introduction: Quantitative electroencephalography (QEEG) brain frequency and network analyses are known to differentiate between disease stages in Parkinson's disease (PD) and are possible biomarkers. They correlate with cognitive decline. Little is known about changes in brain networks in relation to apathy. Objective/Aims: To analyze changes in brain network connectivities related to apathy. Methods: 40 PD patients (14 PD with mild cognitive deficits and 26 PD with normal cognition) were included. All patients had extensive neuropsychological testing; apathy was evaluated using the apathy evaluation score (AES, median 24...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28648721/stability-metrics-for-optic-radiation-tractography-towards-damage-prediction-after-resective-surgery
#7
Stephan Meesters, Pauly Ossenblok, Louis Wagner, Olaf Schijns, Paul Boon, Luc Florack, Anna Vilanova, Remco Duits
BACKGROUND: An accurate delineation of the optic radiation (OR) using diffusion MR tractography may reduce the risk of a visual field deficit after temporal lobe resection. However, tractography is prone to generate spurious streamlines, which deviate strongly from neighboring streamlines and hinder a reliable distance measurement between the temporal pole and the Meyer's loop (ML-TP distance). NEW METHOD: Stability metrics are introduced for the automated removal of spurious streamlines near the Meyer's loop...
August 15, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28610960/no-difference-between-noxious-and-innocuous-thermal-stimulation-on-motor-recovery-of-upper-extremity-in-patients%C3%A2-with-acute-stroke-a-randomized-controlled-trial-with%C3%A2-6-month-follow-up
#8
Roxane Lin, Miao-Ju Hsu, Ruey-Tay Lin, Mao-Hsiung Huang, Chia-Lin Koh, Ching-Lin Hsieh, Jau-Hong Lin
BACKGROUND: Thermal stimulation (TS) has been developed and incorporated into stroke rehabilitation. However, whether noxious and innocuous TS induce the same effects on motor function recovery after stroke is still unknown. A comparative study of different temperature combination regimens is needed. OBJECTIVE: To compare the short- and long-term effectiveness between noxious and innocuous TS on motor recovery of upper extremity in patients with acute stroke. DESIGN: Randomized, controlled trial with concealed allocation, intention-to-treat analysis and blinded outcome assessors...
June 10, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28587872/validation-of-an-automated-tractography-method-for-the-optic-radiations-as-a-biomarker-of-visual-acuity-in-neurofibromatosis-associated-optic-pathway-glioma
#9
REVIEW
Peter de Blank, Michael J Fisher, Haley Gittleman, Jill S Barnholtz-Sloan, Chaitra Badve, Jeffrey I Berman
INTRODUCTION: Fractional anisotropy (FA) of the optic radiations has been associated with vision deficit in multiple intrinsic brain pathologies including NF1 associated optic pathway glioma, but hand-drawn regions of interest used in previous tractography methods limit consistency of this potential biomarker. We created an automated method to identify white matter tracts in the optic radiations and compared this method to previously reported hand-drawn tractography. METHOD: Automated tractography of the optic radiation using probabilistic streamline fiber tracking between the lateral geniculate nucleus of the thalamus and the occipital cortex was compared to the hand-drawn method between regions of interest posterior to Meyer's loop and anterior to tract branching near the calcarine cortex...
June 3, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28587636/recognizing-rna-structural-motifs-in-ht-selex-data-for-ribosomal-protein-s15
#10
Shermin Pei, Betty L Slinger, Michelle M Meyer
BACKGROUND: Proteins recognize many different aspects of RNA ranging from single stranded regions to discrete secondary or tertiary structures. High-throughput sequencing (HTS) of in vitro selected populations offers a large scale method to study RNA-proteins interactions. However, most existing analysis methods require that the binding motifs are enriched in the population relative to earlier rounds, and that motifs are found in a loop or single stranded region of the potential RNA secondary structure...
June 6, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28492588/-a-rare-case-of-intussusception-in-a-seventeen-year-old-boy-diagnosis-management-and-review-of-the-literature
#11
Enrica Rossi, Massimo Basile, Donatella Narese, Noemi Ognibene, Sara Poggesi, Marta Cangelosi, Claudio Defilippi
Intussusception is the most common cause of intestinal obstruction and acute abdomen in the first year of life. Approximately in the 80% of cases intussusception occurs when the last ileal loop is pulled into the cecum, passing through the ileocecal valve, and finally resulting in the displacement of cecum in the upper abdominal. It could be related with mesenteric adenitis because enlarged lymph nodes, together with peristalsis, can serve as "lead point". Other forms of intussusception are ileo-ileal and colo-colic...
April 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28470180/associations-of-the-intellectual-disability-gene-myt1l-with-helix-loop-helix-gene-expression-hippocampus-volume-and-hippocampus-activation-during-memory-retrieval
#12
Agnieszka Kepa, Lourdes Martinez Medina, Susanne Erk, Deepak P Srivastava, Alinda Fernandes, Roberto Toro, Sabine Lévi, Barbara Ruggeri, Cathy Fernandes, Franziska Degenhardt, Stephanie H Witt, Andreas Meyer-Lindenberg, Jean-Christophe Poncer, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Christian P Müller, Andreas Heinz, Henrik Walter, Gunter Schumann, Sylvane Desrivières
The fundamental role of the brain-specific myelin transcription factor 1-like (MYT1L) gene in cases of intellectual disability and in the etiology of neurodevelopmental disorders is increasingly recognized. Yet, its function remains under-investigated. Here, we identify a network of helix-loop-helix (HLH) transcriptional regulators controlled by MYT1L, as indicated by our analyses in human neural stem cells and in the human brain. Using cell-based knockdown approaches and microarray analyses we found that (1) MYT1L is required for neuronal differentiation and identified ID1, a HLH inhibitor of premature neurogenesis, as a target...
December 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28389333/the-thermodynamic-signature-of-ligand-binding-to-histone-deacetylase-like-amidohydrolases-is-most-sensitive-to-the-flexibility-in-the-l2-loop-lining-the-active-site-pocket
#13
Christian Meyners, Andreas Krämer, Özkan Yildiz, Franz-Josef Meyer-Almes
BACKGROUND: The analysis of the thermodynamic driving forces of ligand-protein binding has been suggested to be a key component for the selection and optimization of active compounds into drug candidates. The binding enthalpy as deduced from isothermal titration calorimetry (ITC) is usually interpreted assuming single-step binding of a ligand to one conformation of the target protein. Although successful in many cases, these assumptions are oversimplified approximations of the reality with flexible proteins and complicated binding mechanism in many if not most cases...
July 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28324881/optic-radiation-tractography-and-visual-field-deficits-in-laser-interstitial-thermal-therapy-for-amygdalohippocampectomy-in-patients-with-mesial-temporal-lobe-epilepsy
#14
Dali Yin, John A Thompson, Cornelia Drees, Steven G Ojemann, Lidia Nagae, Victoria S Pelak, Aviva Abosch
BACKGROUND/AIMS: Laser interstitial thermal therapy (LITT) has become an alternative to open-resective surgery for refractory mesial temporal lobe epilepsy (MTLE). Occurrence of visual field defects (VFDs) following open surgery for MTLE is reported at 52-100%. We examined the rate of VFDs following LITT for amygdalohippocampectomy (AHE) and correlated the occurrence of VFDs with damage to the optic radiations, assessed by diffusion tensor tractography (DTI). METHODS: We performed a retrospective analysis of 5 patients who underwent LITT-AHE for medically refractory MTLE...
2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/27951649/crystal-structure-of-a-histone-deacetylase-homologue-from-pseudomonas-aeruginosa
#15
Andreas Krämer, Thomas Wagner, Özkan Yildiz, Franz-Josef Meyer-Almes
Despite the recently growing interest in the acetylation of lysine residues by prokaryotic enzymes, the underlying biological function is still not well understood. Deacetylation is accomplished by proteins that belong to the histone deacetylase (HDAC) superfamily. In this report, we present the first crystal structure of PA3774, a histone deacetylase homologue from the human pathogen Pseudomonas aeruginosa that shares a high degree of homology with class IIb HDACs. We determined the crystal structure of the ligand-free enzyme and protein-ligand complexes with a trifluoromethylketone inhibitor and the reaction product acetate...
December 13, 2016: Biochemistry
https://www.readbyqxmd.com/read/27913638/ms23-a-master-basic-helix-loop-helix-factor-regulates-the-specification-and-development-of-the-tapetum-in-maize
#16
Guo-Ling Nan, Jixian Zhai, Siwaret Arikit, Darren Morrow, John Fernandes, Lan Mai, Nhi Nguyen, Blake C Meyers, Virginia Walbot
Successful male gametogenesis involves orchestration of sequential gene regulation for somatic differentiation in pre-meiotic anthers. We report here the cloning of Male Sterile23 (Ms23), encoding an anther-specific predicted basic helix-loop-helix (bHLH) transcription factor required for tapetal differentiation; transcripts localize initially to the precursor secondary parietal cells then predominantly to daughter tapetal cells. In knockout ms23-ref mutant anthers, five instead of the normal four wall layers are observed...
January 1, 2017: Development
https://www.readbyqxmd.com/read/27895550/closed-loop-task-difficulty-adaptation-during-virtual-reality-reach-to-grasp-training-assisted-with-an-exoskeleton-for-stroke-rehabilitation
#17
Florian Grimm, Georgios Naros, Alireza Gharabaghi
Stroke patients with severe motor deficits of the upper extremity may practice rehabilitation exercises with the assistance of a multi-joint exoskeleton. Although this technology enables intensive task-oriented training, it may also lead to slacking when the assistance is too supportive. Preserving the engagement of the patients while providing "assistance-as-needed" during the exercises, therefore remains an ongoing challenge. We applied a commercially available seven degree-of-freedom arm exoskeleton to provide passive gravity compensation during task-oriented training in a virtual environment...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27871971/speed-bridge-arthroscopic-reinsertion-of-tibial-eminence-fracture-complementary-to-the-adjustable-button-fixation-technique
#18
A Hardy, L Casabianca, O Grimaud, A Meyer
In comminuted fractures of the intercondyloid eminence of the tibial spine, the quality of the reduction and the arthroscopic fixation, notably adjustable suture button fixation, is sometimes disappointing with reduction defects of the anterior bone block. In the Speed-Bridge technique, the two traction sutures of the adjustable button fixation are replaced with two braided sutures of different colors. After the button is placed above the eminence, reduction is obtained by tightening the loop of the button...
February 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27867131/neuronavigation-based-on-track-density-image-extracted-from-deterministic-high-definition-fiber-tractography
#19
Peng-Hu Wei, Fei Cong, Ge Chen, Ming-Chu Li, Xin-Guang Yu, Yu-Hai Bao
BACKGROUND: Diffusion tensor imaging-based navigation is unable to resolve crossing fibers or to determine with accuracy the fanning, origin, and termination of fibers. It is important to improve the accuracy of localizing white matter fibers for improved surgical approaches. We propose a solution to this problem using navigation based on track density imaging extracted from high-definition fiber tractography (HDFT). CASE DESCRIPTION: A 28-year-old asymptomatic female patient with a left-lateral ventricle meningioma was enrolled in the present study...
February 2017: World Neurosurgery
https://www.readbyqxmd.com/read/27822701/aglh-a-thermophilic-udp-n-acetylglucosamine-1-phosphate-dolichyl-phosphate-glcnac-1-phosphotransferase-initiating-protein-n-glycosylation-pathway-in-sulfolobus-acidocaldarius-is-capable-of-complementing-the-eukaryal-alg7
#20
Benjamin H Meyer, Hosam Shams-Eldin, Sonja-Verena Albers
AglH, a predicted UDP-GlcNAc-1-phosphate:dolichyl phosphate GlcNAc-1-phosphotransferase, is initiating the protein N-glycosylation pathway in the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius. AglH successfully replaced the endogenous GlcNAc-1-phosphotransferase activity of Alg7 in a conditional lethal Saccharomyces cerevisiae strain, in which the first step of the eukaryal protein N-glycosylation process was repressed. This study is one of the few examples of cross-domain complementation demonstrating a conserved polyprenyl phosphate transferase reaction within the eukaryal and archaeal domain like it was demonstrated for Methanococcus voltae (Shams-Eldin et al...
January 2017: Extremophiles: Life Under Extreme Conditions
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