Read by QxMD icon Read

Anemia in HIV

Katherine D Westmoreland, Christopher C Stanley, Nathan D Montgomery, Bongani Kaimila, Edwards Kasonkanji, Nader Kim El-Mallawany, Peter Wasswa, Idah Mtete, Mercy Butia, Salama Itimu, Mary Chasela, Mary Mtunda, Maria Chikasema, Victor Makwakwa, Coxcilly Kampani, Bal M Dhungel, Marcia K Sanders, Robert Krysiak, Tamiwe Tomoka, N George Liomba, Dirk P Dittmer, Yuri Fedoriw, Satish Gopal
BACKGROUND: Contemporary descriptions of classical Hodgkin lymphoma (cHL) are lacking from sub-Saharan Africa where human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV) are prevalent. METHODS: We describe a prospective cHL cohort in Malawi enrolled from 2013 to 2015. Patients received standardized treatment and evaluation, including HIV status and EBV testing of tumors and plasma. RESULTS: Among 31 patients with confirmed cHL, the median age was 19 years (range, 2-51 years) and 22 (71%) were male...
October 26, 2016: Pediatric Blood & Cancer
Silvana Opp, Thomas Fricke, Caitlin Shepard, Dmytro Kovalskyy, Akash Bhattacharya, Frank Herkules, Dmitri N Ivanov, Kim Baek, Jose Valle-Casuso, Felipe Diaz-Griffero
The small molecule 6-(tert-butyl)-4-phenyl-4-(trifluoromethyl)-1H,3H-1,3,5-triazin-2-one (3G11) inhibits HIV-1 replication in the human T cell line MT-2. Here we showed that 3G11 specifically and potently blocks HIV-1 infection. By contrast, 3G11 did not block other retroviruses such as HIV-2, simian immunodeficiency virus (SIVmac ), bovine immunodeficiency virus (BIV), feline immunodeficiency virus (FIV), equine infectious anemia virus (EIAV), N-tropic murine leukemia virus (N-MLV), B-tropic murine leukemia virus (B-MLV) and Moloney murine leukemia virus (Mo-MLV)...
October 17, 2016: Chemical Biology & Drug Design
Geraldine Hall, Karen C Carroll
Aerobic Gram-positive and Gram-negative bacteria can be important pathogens in the immunocompromised host. These bacteria can be found in many environments, as part of the normal microbiota of the human host and animals, in soil and water, on plants, on fomites in the hospital, and on hospital equipment. This review provides information from relevant studies about what are the most common aerobic bacteria associated with patients who have cancer and/or are being treated for it, or who have other diseases which lead to immunodeficiencies, such as HIV, multiple myeloma, aplastic anemia, chronic diseases, and aging...
August 2016: Microbiology Spectrum
Nina E Diana, Saraladevi Naicker
The prevalence of HIV-associated chronic kidney disease (CKD) varies geographically and depends on the definition of CKD used, ranging from 4.7% to 38% globally. The incidence, however, has decreased with the use of effective combined antiretroviral therapy (cART). A wide variety of histological patterns are seen in HIV-associated kidney diseases that include glomerular and tubulointerstitial pathology. In resource-rich settings, there has been a plateau in the incidence of end-stage renal disease secondary to HIV-associated nephropathy (HIVAN)...
2016: International Journal of Nephrology and Renovascular Disease
Kalvin C Yu, Paul A D'Avanzo, Leigh Nesheiwat, Richard E Greene, Antonio Urbina, Perry N Halkitis, Farzana Kapadia
Data from a cross-sectional study of a clinic-based sample of older people living with HIV (PLWH; n = 100) were used to examine associations between biomarkers of physical health and neurocognitive impairment (NCI). In this sample, anemia, chronic kidney disease (CKD) stages 4-5, and hypocalcemia were associated with impairment in executive functioning or processing speed. Furthermore, participants with anemia were more likely to have CD4+ T cell counts <200 cells/mm(3) (χ(2) [1] = 19.57, p < ...
August 27, 2016: Journal of the Association of Nurses in AIDS Care: JANAC
Ravish Kshatriya, Viral Patel, Sanjay Chaudhari, Purvesh Patel, Dhaval Prajapati, Nimit Khara, Rajiv Paliwal, Sateesh Patel
Pulmonary tuberculosis is commonly presented as cavitary lesion and infiltrations. It commonly involves upper lobe. Lower lobe involvement is less common. Various atypical presentations of tuberculosis on radiology are reported like mass, solitary nodule, multi lober involvement including lower lobes. Atypical presentations are more commo in patients with immunocompromised conditions like Diabetes Mellitus, anemia, renal failure, liver diseases, HIV infection, malignancy, patients on immunosuppressive therapy...
September 2016: Lung India: Official Organ of Indian Chest Society
Sai-Nan Bian, Li-Fan Zhang, Yue-Qiu Zhang, Qi-Wen Yang, Peng Wang, Ying-Chun Xu, Xiao-Chun Shi, Xiao-Qing Liu
BACKGROUND: Nontuberculous Mycobacterium (NTM) bloodstream infection (BSI) is relatively rare. We aimed in this study to evaluate the clinical characteristics, laboratory evaluation, and outcomes of patients with NTM BSI. METHODS: We retrospectively reviewed the clinical records of inpatients with NTM BSI at our institution between January 2008 and January 2015 and recorded clinical parameters including age, gender, underlying disease, clinical manifestation, organs involved with NTM disease, species of NTM, laboratory data, treatment and outcome of these patients...
2016: Chinese Medical Journal
Mwayiwawo Madanitsa, Linda Kalilani, Victor Mwapasa, Anna M van Eijk, Carole Khairallah, Doreen Ali, Cheryl Pace, James Smedley, Kyaw-Lay Thwai, Brandt Levitt, Duolao Wang, Arthur Kang'ombe, Brian Faragher, Steve M Taylor, Steve Meshnick, Feiko O Ter Kuile
BACKGROUND: In Africa, most plasmodium infections during pregnancy remain asymptomatic, yet are associated with maternal anemia and low birthweight. WHO recommends intermittent preventive therapy in pregnancy with sulfadoxine-pyrimethamine (IPTp-SP). However, sulfadoxine-pyrimethamine (SP) efficacy is threatened by high-level parasite resistance. We conducted a trial to evaluate the efficacy and safety of scheduled intermittent screening with malaria rapid diagnostic tests (RDTs) and treatment of RDT-positive women with dihydroartemisinin-piperaquine (DP) as an alternative strategy to IPTp-SP...
September 2016: PLoS Medicine
Farid Kheloufi, Isabelle Poizot-Martin, Rodolphe Garraffo, Aude Tavenard, Sylvie Quaranta, Alain Renault, Thibault Lavrut, Marc Bourlière, Philippe Halfon, Lionel Piroth, Eric Bellissant, Bruno Lacarelle, Jean-Michel Molina, Caroline Solas, Boceprevih Study Group
BACKGROUND: We aimed to determine the impact of inosine triphosphatase (ITPA) deficiency on ribavirin (RBV) induced anemia in HIV-HCV co-infected patients receiving a triple therapy including the hematotoxic direct-acting antiviral agent boceprevir (BOC). METHODS: Patients of the ANRS HC27 BocepreVIH study were genotyped for 2 ITPA Single nucleotide polymorphisms involved in ITPA deficiency. RBV trough concentration (Ctrough) was determined at W4 and W8. Impact of ITPA deficiency on anemia, RBV Ctrough, response and hematotoxicity (grade 3/4 anemia, EPO use, RBV dose reduction or transfusion between D0 and W8) was evaluated...
September 1, 2016: Antiviral Therapy
Satish Tiwari, Ketan Bharadva, Balraj Yadav, Sushma Malik, Prashant Gangal, C R Banapurmath, Zeeba Zaka-Ur-Rab, Urmila Deshmukh, - Visheshkumar, R K Agrawal
JUSTIFICATION: Shaping up the post-2015 development agenda is of crucial importance in the development process around the Globe as 2015 was the last year of milllionium development goals. It is the right time to asses our own progress vis-a-vis the Millennium Development Goals and these Guidelines are an attempt in that regard. PROCESS: The Infant and Young Child Feeding (IYCF) chapter of Indian Academy of Pediatrics invited a group of experts for National Consultative Meet for discussing and contributing on latest scientific advances and developments...
August 8, 2016: Indian Pediatrics
Amira El-Messidi, Nicholas Czuzoj-Shulman, Andrea R Spence, Haim Arie Abenhaim
BACKGROUND: Worldwide, tuberculosis remains a major health concern, with an estimated 9.6 million people infected in the year 2014, of which one-third were women. Tuberculosis is estimated to be even more prevalent in pregnant women than the general population. To date there is conflicting evidence on the maternal and neonatal complications of tuberculosis in pregnancy OBJECTIVE: To determine the trends in the incidence of tuberculosis in pregnancy and to examine the associations between tuberculosis in pregnancy and maternal and fetal complications...
August 13, 2016: American Journal of Obstetrics and Gynecology
Edmond K Kabagambe, Amara E Ezeamama, David Guwatudde, Hannia Campos, Wafaie Fawzi
BACKGROUND: Fatty-acids, including n6 series, modulate immune function but their effect on CD4 cell counts, death or hospitalization in HIV-infected patients on antiretroviral therapy is unknown. METHODS: In a randomized trial for effects of multivitamins in HIV-infected patients in Uganda, we used gas chromatography to measure plasma n6-fatty acids at baseline, determined CD4 counts at baseline, 3, 6, 12 and 18 months and recorded hospitalization or death events...
August 13, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Berhanu Elfu Feleke
Children, especially infants, are highly vulnerable to iron-deficiency anemia because of their rapid growth of the brain and the rest of the body. The objectives of this study were to compare the prevalence of iron-deficiency anemia in infants born from HIV-positive mothers and HIV-negative mothers and to identify the determinants of iron-deficiency anemia in infants.A comparative cross-sectional study was conducted in Bahir Dar city. Simple random sampling technique was used to select the study participants...
August 2016: Medicine (Baltimore)
Jason Shayne Dazley, Lakshmi Durga Sriramulu, Jihad Slim
Hepatitis C virus infection is a hot topic for both effective treatment and elevated cost. This case series describes the cost saving for the healthcare system of any nation of treating HCV in many situations, including that of overt cirrhosis. Case#1 is of a HCV/HIV infected cirrhotic patient with MELD score of 17, Child Pugh score B, recurrent esophageal bleeds ceased after successful treatment with sofosbuvir and simepravir. Case#2 is a patient also co-infected with HCV/HIV MELD score of 18, Child Pugh score B, with grade 3 esophageal varices and frequent bleed with significant anemia...
July 30, 2016: Journal of Infection and Public Health
Susan Meiring, Melony Fortuin-de Smidt, Ranmini Kularatne, Halima Dawood, Nelesh P Govender
BACKGROUND: We aimed to establish the prevalence of amphotericin B deoxycholate (AmBd)-related toxicities among South African patients with cryptococcosis and determine adherence to international recommendations to prevent, monitor and manage AmBd-related toxicities. METHODS: Clinical data were collected from cases of laboratory-confirmed cryptococcosis at 25 hospitals, October 2012 -February 2013. Anemia was defined as hemoglobin (Hb) concentration <10 g/dl, hypokalemia as serum potassium (K) <3...
July 2016: PLoS Neglected Tropical Diseases
Adetokunbo O Tayo, Adedoyin O Dosunmu, Ireti O Akinola, Adeniyi Adewunmi, Olufemi A Oloyede, Akinsegun A Akinbami, Bodunrin I Osikomaiya, Samira B L Makanjuola
OBJECTIVE: Anemia in patients presenting for elective surgery is associated with increased morbidity, allogeneic blood transfusion, and delay of surgery. Extract of sorghum bicolor has been shown to have hemopoietic, immune-stimulating, and antioxidant effects in rats and in patients with HIV. The aim of this study was to determine the effect of the extract in patients with preoperative anemia booked for myomectomy. METHODS: Consenting patients (N = 66) were randomly assigned to two groups...
May 18, 2016: Nutrition
Jiehua Qiu, Weimin Zhou, Wei Zhou, Xinhua Tang, Qingwen Yuan, Xianhua Zhu, Yujin Yang, Jixin Xiong
BACKGROUND: The purpose of our study is to analyze the methods of treating infected femoral artery pseudoaneurysms (IFAPs), and also to identify the most appropriate method, especially for patients with a long history of drug abuse. METHODS: A retrospective chart review of 88 consecutive IFAPs secondary to drug abuse between 2003 and 2014 was performed. Outpatient clinic charts were reviewed, as well as inpatient and anesthesia records. All patients had undergone a computer tomography angiography or contrast computer tomography to confirm their diagnosis...
July 15, 2016: Annals of Vascular Surgery
Iréne McLachlan, Willem I Visser, H Francois Jordaan
BACKGROUND: The current pandemic of tuberculosis (TB) and human immunodeficiency virus (HIV) co-infection, the modern era of antiretroviral therapy, and the rising incidence of multidrug-resistant TB have led to a broader spectrum of skin conditions in patients hospitalized with TB. These factors also influence investigations into possible causal relationships with TB. OBJECTIVES: The aim of this study was to describe mucocutaneous conditions found in patients hospitalized with TB and to report associated factors...
July 15, 2016: International Journal of Dermatology
Flávia Fonseca Fernandes, Victor Oliveira Alves, Tarquino Erastides Gavilanes Sánchez, Wagner Diniz de Paula, Alfredo Nicodemos Cruz Santana
A previously healthy, 52-year-old woman presented with a nine months history of low fever and weight loss (> 30 kg). Physical examination disclosed generalized lymphadenopathy, skin lesions, abdominal distension, mild tachypnea and a left breast mass. Laboratory tests showed anemia; (prerenal) kidney injury, low serum albumin level; and negative serology for HIV and viral hepatitis. Computed tomography (neck/chest/abdomen) showed generalized lymph node enlargement, splenomegaly, pleural effusion and ascites...
July 11, 2016: Revista do Instituto de Medicina Tropical de São Paulo
Thanigachalam Dineshkumar, Jeyachandran Dhanapriya, Palanivel Jaganathan, Ramanathan Sakthirajan, Natarajan Gopalakrishnan, T Balasubramaniyan
Thrombotic microangiopathy (TMA) is characterized by microangiopathic hemolytic anemia, thrombocytopenia, microvascular thrombosis, and various organ dysfunctions. TMA usually occurs in a more advanced stage of HIV disease. TMA as an initial presenting feature is rare. We here report a male patient who presented with oliguric renal failure. Investigations revealed anemia, thrombocytopenia, schistocytes in peripheral smear, and HIV-positive. Renal biopsy revealed TMA. He was treated with hemodialysis and started on highly active antiretroviral therapy...
June 2016: Indian Journal of Critical Care Medicine
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"