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Anemia in HIV

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https://www.readbyqxmd.com/read/29677205/anemia-in-tuberculosis-cases-and-household-controls-from-tanzania-contribution-of-disease-coinfections-and-the-role-of-hepcidin
#1
Jerry Hella, Colin I Cercamondi, Francis Mhimbira, Mohamed Sasamalo, Nicole Stoffel, Marcel Zwahlen, Thomas Bodmer, Sebastien Gagneux, Klaus Reither, Michael B Zimmermann, Lorenz Risch, Lukas Fenner
BACKGROUND: Tuberculosis (TB) induces a systemic inflammatory state affecting iron homeostasis. Patients with TB often have additional comorbidities such as anemia which can result in poorer treat outcomes. We studied the contribution of anemia and the role of the iron regulatory hormone hepcidin among TB patients and household contacts. METHODS: We analyzed serum samples from 102 TB cases and 98 controls without TB, matched by age/sex, for hepcidin, iron, and inflammation parameters...
2018: PloS One
https://www.readbyqxmd.com/read/29672871/sex-differences-in-the-contemporary-management-of-hiv-patients-admitted-for-acute-myocardial-infarction
#2
Gbolahan O Ogunbayo, Katrina Bidwell, Naoki Misumida, Le Dung Ha, Ahmed Abdel-Latif, Claude S Elayi, Susan Smyth, Adrian W Messerli
BACKGROUND: Studies have reported sex differences in the management of patients with acute myocardial infarction (AMI) in the general population. This observational study is designed to evaluate whether sex differences exist in the contemporary management of human immunodeficiency virus (HIV) patients admitted for diagnosis of AMI. HYPOTHESIS: There is no difference in management of HIV patients with AMI. METHODS: Using the National Inpatient Sample database, we identified patients with a primary diagnosis of AMI and a secondary diagnosis of HIV...
April 19, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29672628/derivation-and-internal-validation-of-a-mortality-risk-index-for-aged-people-living-with-hiv-the-dat-aids-score
#3
Maxime Hentzien, Cyrille Delpierre, Pascal Pugliese, Clotilde Allavena, Christine Jacomet, Marc-Antoine Valantin, André Cabié, Lise Cuzin, David Rey, Firouzé Bani-Sadr, Moustapha Dramé
OBJECTIVE: The objective was to develop a multivariable prognostic index for overall mortality over a five-year span integrating classical HIV biomarkers and comorbidities in people living with HIV (PLHIV) aged 60 or older. DESIGN: Prospective multicenter cohort study from the French Dat'AIDS cohort. METHODS: All HIV-1 infected patients aged 60 years or older on 1st January 2008 were included. Sociodemographic data, CD4 cell count, CD4 nadir, HIV viral load, history of comorbidities, hepatitis co-infections and laboratory parameters at baseline were considered as potential prognostic variables...
2018: PloS One
https://www.readbyqxmd.com/read/29663621/neurodevelopmental-outcomes-of-young-children-born-to-hiv-positive-mothers-in-rural-yunnan-china
#4
Jie Wu, Jing Li, Yan Li, Kek Khee Loo, Haixia Yang, Qiong Wang, Rufei Duan, Xia Xiao, Xiaoxiao Song, Siwei Yang, Lin Sun
BACKGROUND: Children born to HIV-infected mothers are at risk for neurodevelopmental delay. Little is known about neurodevelopmental outcomes of infants and toddlers who were born to HIV-positive mothers but were not themselves infected by HIV, especially in poor rural areas. This study was conducted to compare developmental outcomes between young children who were HIV-exposed but uninfected (HEU) and their HIV-unexposed and uninfected (HUU) peers in rural Yunnan, China. METHODS: A total of 250 HEU children aged 6-36 months and 250 HUU children matched on age, gender and residency were recruited from rural Yunnan, China...
April 16, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29649107/impaired-hematologic-status-in-relation-to-clinical-outcomes-among-hiv-infected-adults-from-uganda-a-prospective-cohort-study
#5
Amara E Ezeamama, David Guwatudde, Alla Sikorskii, Edmond K Kabagambe, Raybun Spelts, Grace Vahey, Jenifer I Fenton, Wafaie W Fawzi
Impaired hematologic status (IHS) was investigated as a determinant of immune function defined as cluster of differentiation 4 (CD4) T-helper cell count, quality of life (QOL) weight and hospitalization/mortality over 18-months among 398 adult persons living with HIV/AIDS (PLWHA) on anti-retroviral therapy. IHS was defined as having anemia at baseline (Hemoglobin: <12 g/dL for women and <13 g/dL for men), time-updated anemia or having low (<30 μg/L) or high (>200 μg/L for men and >150 μg/L for women) ferritin levels at baseline...
April 12, 2018: Nutrients
https://www.readbyqxmd.com/read/29622909/anemia-among-hiv-infected-individuals-taking-art-with-and-without-zidovudine-at-addis-ababa-ethiopia
#6
Zemenu Tamir, Jemal Alemu, Aster Tsegaye
Background: Hematological complications such as Zidovudine(ZDV) associated anemia are among the commonly reported adverse drug reactions of Antiretroviral Therapy(ART). Little is known about ZDV associated anemia in developing countries like Ethiopia. Methods: Comparative retrospective cohort study was conducted at the ART Clinic of St. Paul Hospital Millennium Medical College from February 2011 to December 2012 to characterize anemia among HIV/AIDS patients initiated with ZDV and non-ZDV containing ART regimens...
January 2018: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29568529/prevalence-of-anemia-before-and-after-initiation-of-antiretroviral-therapy-among-hiv-infected-patients-at-black-lion-specialized-hospital-addis-ababa-ethiopia-a-cross-sectional-study
#7
Gashaw Garedew Woldeamanuel, Diresibachew Haile Wondimu
Background: Anemia is the most common hematological abnormality in Human immunodeficiency virus (HIV) positive patients and a significant predictor of its progression to AIDS or death. This study was aimed to assess the prevalence of anemia before and after initiation of antiretroviral therapy (ART) among HIV positive patients attending Black Lion Specialized Hospital, Addis Ababa, Ethiopia. Methods: A cross sectional study was conducted from January to April, 2017 in Black Lion Specialized Hospital, Addis Ababa, Ethiopia...
2018: BMC Hematology
https://www.readbyqxmd.com/read/29564278/thrombocytopenia-in-hiv-patients-coinfected-with-tuberculosis
#8
A S Sandhya, Brijesh Prajapat
Thrombocytopenia is one of the most common hematological manifestations seen in HIV patients with approximately 40% of the patients developing thrombocytopenia during their course of illness. Opportunistic infection like tuberculosis is a rare but curative cause of thrombocytopenia in these patients. Clinically, it is a challenge to determine the exact cause and decide the treatment of thrombocytopenia in these patients as both infections can lead to significant thrombocytopenia by varied mechanisms. The treatment options are limited by drug antitubercular treatment highly active antiretroviral therapy (ATT and HAART)-induced thrombocytopenia...
October 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29539274/antifungal-combinations-for-treatment-of-cryptococcal-meningitis-in-africa
#9
RANDOMIZED CONTROLLED TRIAL
Síle F Molloy, Cecilia Kanyama, Robert S Heyderman, Angela Loyse, Charles Kouanfack, Duncan Chanda, Sayoki Mfinanga, Elvis Temfack, Shabir Lakhi, Sokoine Lesikari, Adrienne K Chan, Neil Stone, Newton Kalata, Natasha Karunaharan, Kate Gaskell, Mary Peirse, Jayne Ellis, Chimwemwe Chawinga, Sandrine Lontsi, Jean-Gilbert Ndong, Philip Bright, Duncan Lupiya, Tao Chen, John Bradley, Jack Adams, Charles van der Horst, Joep J van Oosterhout, Victor Sini, Yacouba N Mapoure, Peter Mwaba, Tihana Bicanic, David G Lalloo, Duolao Wang, Mina C Hosseinipour, Olivier Lortholary, Shabbar Jaffar, Thomas S Harrison
BACKGROUND: Cryptococcal meningitis accounts for more than 100,000 human immunodeficiency virus (HIV)-related deaths per year. We tested two treatment strategies that could be more sustainable in Africa than the standard of 2 weeks of amphotericin B plus flucytosine and more effective than the widely used fluconazole monotherapy. METHODS: We randomly assigned HIV-infected adults with cryptococcal meningitis to receive an oral regimen (fluconazole [1200 mg per day] plus flucytosine [100 mg per kilogram of body weight per day] for 2 weeks), 1 week of amphotericin B (1 mg per kilogram per day), or 2 weeks of amphotericin B (1 mg per kilogram per day)...
March 15, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29524085/a-literature-review-of-blood-disseminated-p-marneffei-infection-and-a-case-study-of-this-infection-in-an-hiv-negative-child-with-comorbid-eosinophilia
#10
Xiu-Jing Han, Dan-Hong Su, Jian-Yun Yi, Ya-Wei Zou, Yu-Ling Shi
BACKGROUND: The typical manifestations of Penicillium marneffei (nowadays Talaromyces marneffei) infection in children without human immunodeficiency virus (HIV) remain unclear. The current work presents the case of a child without an underlying disease who was infected with P. marneffei comorbid with eosinophilia. CASE PRESENTATION: A 2-year-old male was infected with P. marneffei. A physical examination revealed a high-grade fever, ulcerated lesions in the oral mucosa, anemia, pruritic erythematous papules on the sac and thigh and watery diarrhea...
March 9, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29522982/financial-decision-making-power-is-associated-with-moderate-to-severe-anemia-a-prospective-cohort-study-among-pregnant-women-in-rural-south-india
#11
Karl Krupp, Caitlyn D Placek, Meredith Wilcox, Kavitha Ravi, Vijaya Srinivas, Anjali Arun, Purnima Madhivanan
OBJECTIVE: According to the World Health Organization, about half of all pregnant women in India suffer from some form of anemia. While poor nutrition is the most common cause, social factors, such as gender and religion, also impact anemia status. This study investigates the relationship between anemia and socioeconomic and health-related factors among pregnant women in Mysore, India. DESIGN: Prospective cohort study conducted between January 2009 and 2012 SETTING: 144 rural villages ten or more kilometers outside of Mysore City received integrated antenatal care and HIV testing services provided by mobile medical clinic in their communities...
February 20, 2018: Midwifery
https://www.readbyqxmd.com/read/29477186/practice-paper-of-the-academy-of-nutrition-and-dietetics-nutrition-intervention-and-human-immunodeficiency-virus-infection
#12
Amanda Willig, Lauri Wright, Theresa A Galvin
Nutrition is an integral component of medical care for people living with human immunodeficiency virus (HIV)/autoimmune deficiency syndrome (AIDS) (PLWHA). The Academy of Nutrition and Dietetics supports integration of medical nutrition therapy into routine care for this population. Fewer PLWHA experience wasting and undernutrition, while the prevalence of obesity and other chronic diseases has increased significantly. Improved understanding of HIV infection's impact on metabolism and chronic inflammation has only increased the complexity of managing chronic HIV infection...
March 2018: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29474356/management-of-severe-strongyloidiasis-attended-at-reference-centers-in-spain
#13
Angela Martinez-Perez, Silvia Roure Díez, Moncef Belhassen-Garcia, Diego Torrús-Tendero, Jose Luis Perez-Arellano, Teresa Cabezas, Cristina Soler, Marta Díaz-Menéndez, Miriam Navarro, Begoña Treviño, Fernando Salvador
INTRODUCTION: Strongyloides stercoralis is a globally distributed nematode that causes diverse clinical symptoms in humans. Spain, once considered an endemic country, has experienced a recent increase in imported cases. The introduction of serology helps diagnosis and is currently replacing microbiological techniques in some settings, but its sensitivity is variable and can be low in immunocompromised patients. Diagnosis can only be confirmed by identification of larvae. Often, this "gold standard" can only be achieved in severe cases, such as disseminated S...
February 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29455264/mortality-rate-and-predictors-in-children-under-15-years-old-who-acquired-hiv-from-mother-to-child-transmission-in-paraguay
#14
Gloria Aguilar, Angélica Espinosa Miranda, George W Rutherford, Sergio Munoz, Nancy Hills, Tania Samudio, Fernando Galeano, Anibal Kawabata, Carlos Miguel Rios González
We estimated mortality rate and predictors of death in children and adolescents who acquired HIV through mother-to-child transmission in Paraguay. In 2000-2014, we conducted a cohort study among children and adolescents aged < 15 years. We abstracted data from medical records and death certificates. We used the Cox proportional hazards model for the multivariable analysis of mortality predictors. A total of 302 subjects were included in the survey; 216 (71.5%) were younger than 5 years, 148 (51.0%) were male, and 214 (70...
February 17, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29424337/successful-use-of-rituximab-in-glomerular-basement-membrane-nephritis-associated-with%C3%A2-hiv-interstitial-nephritis-secondary-to-castleman-disease%C3%A2
#15
Nathan Calabro, Kammi Henriksen, Seah H Lim, Eric Kerns
We report a case of glomerular basement membrane crescentic glomerulonephritis and multicentric Castleman disease-associated interstitial nephritis in a patient with human immunodeficiency virus (HIV) infection. The patient received corticosteroids, cyclophosphamide, and plasmapheresis, and within 3 weeks, there was worsening thrombocytopenia, anemia, and renal function requiring initiation of hemodialysis. He then received 8 weekly doses of rituximab, and there was steady improvement in renal function, such that he stopped dialysis within 6 weeks and has remained in disease remission at 1-year follow-up...
February 9, 2018: Clinical Nephrology
https://www.readbyqxmd.com/read/29406463/malnutrition-growth-response-and-metabolic-changes-within-the-first-24-months-after-art-initiation-in-hiv-infected-children-treated-before-the-age-of-two-years-in-west-africa
#16
Julie Jesson, Désiré L Dahourou, Madeleine Amorissani Folquet, Karen Malateste, Caroline Yonaba, Marie-Sylvie N'Gbeche, Sylvie Ouédraogo, Véronique Mea-Assande, Clarisse Amani-Bossé, Stéphane Blanche, Marguerite Timité-Konan, Valériane Leroy
BACKGROUND: There is limited information about malnutrition, growth evolution and metabolic changes among children initiated early on lopinavir-based antiretroviral therapy (ART) in Africa. METHODS: HIV-1-infected children, age <2 years were initiated on ART, as part of the MONOD ANRS 12206 project, conducted in Burkina Faso and Côte d'Ivoire. Weight-for-age, height-for-age and weight-for-height Z-scores (WAZ, HAZ, WHZ) defined malnutrition (Z-score <-2 standard deviations [SD]) using WHO growth references...
February 3, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29390523/efficacy-of-eculizumab-in-an-adult-patient-with-hiv-associated-hemolytic-uremic-syndrome-a-case-report
#17
Marine Freist, Cyril Garrouste, Nora Szlavik, Paul Coppo, Alexandre Lautrette, Anne Elisabeth Heng
INTRODUCTION: Hemolytic uremic syndrome (HUS) in Human Immunodeficiency Virus (HIV)-positive patients has become a rare cause of kidney injury since the era of highly active antiretroviral therapy (HAART). Plasma exchange and antiretroviral therapy were previously recommended but often failed to achieve remission. We report a case of HUS in a HIV-positive patient treated successfully with eculizumab. CASE SUMMARY: A 52-year-old woman presented to hospital with acute renal failure, thrombocytopenia, anemia, and hypoxemia...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29334932/anemia-in-people-on-second-line-antiretroviral-treatment-in-lilongwe-malawi-a-cross-sectional-study
#18
McNeil Ngongondo, Nora E Rosenberg, Christopher C Stanley, Robertino Lim, Dennis Ongubo, Richard Broadhurst, Colin Speight, Robert Flick, Petros Tembo, Mina C Hosseinpour
BACKGROUND: Anemia is common among people living with HIV infection and is frequently associated with poor quality of life and poor prognosis. It has been well described in antiretroviral naïve individuals and those on non-nucleoside reverse transcriptase inhibitor-based first line antiretroviral therapy (ART) regimens. However there is limited information on anemia for ART experienced individuals on protease inhibitor-based second line ART regimens in resource limited settings. Our objective was to describe the prevalence and risk factors of anemia in this ART experienced population in Malawi...
January 15, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29313506/prevalence-of-tb-hiv-coinfection-in-antiretroviral-na%C3%A3-ve-patients-at-the-fann-ambulatory-treatment-center-in-dakar
#19
D Ka, N F Ngom Guéye, N Fall, N O Touré-Badiane, N Diop, G Batista, K Ndiaye, C T Ndour, M Seydi, M A Faye
To determine the prevalence of tuberculosis and describe its epidemiological, clinical, paraclinical, and therapeutic characteristics and its outcome in patients with HIV. This retrospective, descriptive, and analytical study examined the records of patients with HIV at our outpatient treatment center and selected those who were antiretroviral-naive and presented tuberculosis between January 2008 and December 2012. Among a total of 757 HIV-positive patients, 76 had tuberculosis, for a prevalence of 10 %. The sex ratio of 1...
November 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/29313475/impact-of-antiretroviral-therapy-on-the-risk-of-herpes-zoster-among-human-immunodeficiency-virus-infected-individuals-in-tanzania
#20
Kosuke Kawai, Claudia A Hawkins, Ellen Hertzmark, Joel M Francis, David Sando, Aisa N Muya, Nzovu Ulenga, Wafaie W Fawzi
We examined the incidence of herpes zoster (HZ) before and after the initiation of antiretroviral therapy (ART), and risk factors for HZ among human immunodeficiency virus (HIV)-infected individuals in Tanzania. A cohort study was conducted among HIV-positive individuals enrolled in HIV care and treatment clinics in Dar es Salaam, Tanzania. A Cox proportional hazard model was used to examine the effect of ART on the risk of HZ after adjusting for sociodemographics and time-varying clinical and nutritional factors...
February 2018: American Journal of Tropical Medicine and Hygiene
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