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https://www.readbyqxmd.com/read/29666304/strategic-therapeutic-targeting-to-overcome-venetoclax-resistance-in-aggressive-b-cell-lymphomas
#1
Lan V Pham, Shengjian Huang, Hui Zhang, Jun Zhang, Taylor Bell, Shouhao Zhou, Elizabeth Pogue, Zhiyong Ding, Laura Lam, Jason R Westin, R Eric Davis, Ken H Young, L Jeffrey Medeiros, Richard J Ford, Krystle Nomie, Liang Zhang, Michael Wang
PURPOSE: B-cell lymphoma-2 (BCL-2), an anti-apoptotic protein often dysregulated in B-cell lymphomas, promotes cell survival and provides protection from stress. A recent Phase I first-in-human study of the BCL-2 inhibitor venetoclax in non-Hodgkin lymphoma showed an overall response rate of 44%. These promising clinical results prompted our examination of the biological effects and mechanism of action underlying venetoclax activity in aggressive B-cell lymphoma, including mantle cell lymphoma (MCL) and diffuse large B cell lymphoma (DLBCL)...
April 17, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29666114/chronic-lymphocytic-leukemia-and-mantle-cell-lymphoma-crossroads-of-genetic-and-microenvironment-interactions
#2
Xose S Puente, Pedro Jares, Elias Campo
Chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) are two well defined entities that diverge in their basic pathogenic mechanisms and clinical evolution but they share epidemiological characteristics, cells of origin, molecular alterations, and clinical features that differ from other lymphoid neoplasms. CLL and MCL are classically considered indolent and aggressive neoplasms, respectively. However, the clinical evolution of both tumors is very heterogeneous, with subsets of patients having a stable disease for long time whereas others require immediate intervention...
April 17, 2018: Blood
https://www.readbyqxmd.com/read/29666100/a-rare-involvement-of-epitrochlear-lymph-nodes-in-mantle-cell-lymphoma
#3
Mohan Kumar, Gaurav Prakash, Kundan Mishra, Savita Kumari
No abstract text is available yet for this article.
April 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29666081/mantle-cell-lymphoma-presenting-as-bilateral-adrenal-huge-masses
#4
Abtin Doroudinia, Mehrdad Bakhshayesh Karam, Mostafa Ranjbar, Arash Nikmanesh, Payam Mehrian
We present a middle-aged woman complaining of weakness, lethargy and weight loss for 6 months. Positron emission tomography (PET)/CT scan revealed huge bilateral adrenal masses with intense 18F-fluorodeoxyglucose avidity. Biopsy and immunohistochemical staining were compatible with mantle cell lymphoma (MCL). The patient received six cycles of rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP) followed by four cycles of intrathechal methotrexate chemotherapy. Bone marrow aspiration biopsy was performed for initial staging and also before bone marrow transplantation...
April 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29658927/tumor-engraftment-in-a-xenograft-mouse-model-of-human-mantle-cell-lymphoma
#5
Archana Vijaya Kumar, Carmen Donate, Beat A Imhof, Thomas Matthes
B lymphocytes are key players in immune cell circulation and they mainly home to and reside in lymphoid organs. While normal B cells only proliferate when stimulated by T lymphocytes, oncogenic B cells survive and expand autonomously in undefined organ niches. Mantle cell lymphoma (MCL) is one such B cell disorder, where the median survival rate of patients is 4 - 5 years. This calls for the need of effective mechanisms by which the homing and engraftment of these cells are blocked in order to increase the survival and longevity of patients...
March 30, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29651351/acquired-von-willebrand-disease-associated-with-mantle-cell-lymphoma
#6
Dominique Maas, Britta Laros-van Gorkom, Sanne Gianotten, Marjan Cruijsen, Waander van Heerde, Marten Nijziel
We present a rare case of acquired von Willebrand syndrome (AVWS) caused by a mantle cell lymphoma. A 61-year-old male suffered from recurrent bleeding symptoms since a few months. Initially, physical examination was normal. von Willebrand factor antigen (VWF:Ag) level and factor VIII activity (FVIII:C) were low (0.31 IU/ml and 0.43 IU/ml, resp.). Ristocetin cofactor activity (VWF:RCo) was 0.09 IU/ml, and collagen binding activity (VWF:CB) was 0.10 IU/ml. VWF:RCo/VWF:Ag ratio was 0.29, and RIPA value was normal...
2018: Case Reports in Hematology
https://www.readbyqxmd.com/read/29626463/cryopreservation-of-cultured-mantle-cells-of-paphia-malabarica-for-perennial-availability
#7
Shanti N Dessai
Laboratory friendly, cryopreservation procedures with respect to cryopreservation formulations and cryopreservation temperatures were attempted, in the present study to ensure perennial availability of cultured mantle cells of bivalve (Paphia malabarica). Screening of cryopreservative formulations with different concentrations of DMSO, Propylene glycol and Glycerol was carried out for cryopreservation of freshly dissociated cells of Paphia malabarica. Out of these cryopreservative formulations, 10% DMSO, 10% Propylene glycol and 15% Glycerol were selected for cryopreservation of the mantle cells pooled from 1-day old primary culture and cell line after 3 passages at the end of different cryopreservation periods...
April 4, 2018: Cryobiology
https://www.readbyqxmd.com/read/29626063/ibrutinib-plus-venetoclax-may-be-effective-in-mantle-cell-lymphoma
#8
(no author information available yet)
Ibrutinib plus venetoclax is superior to monotherapy in patients with mantle-cell lymphoma.
April 6, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29624684/the-ectomycorrhizal-basidiomycete-laccaria-bicolor-releases-a-secreted-%C3%AE-1-4-endoglucanase-that-plays-a-key-role-in-symbiosis-development
#9
Feng Zhang, George E Anasontzis, Aurore Labourel, Charlotte Champion, Mireille Haon, Minna Kemppainen, Carine Commun, Aurélie Deveau, Alejandro Pardo, Claire Veneault-Fourrey, Annegret Kohler, Marie-Noëlle Rosso, Bernard Henrissat, Jean-Guy Berrin, Francis Martin
In ectomycorrhiza, root ingress and colonization of the apoplast by colonizing hyphae is thought to rely mainly on the mechanical force that results from hyphal tip growth, but this could be enhanced by secretion of cell-wall-degrading enzymes, which have not yet been identified. The sole cellulose-binding module (CBM1) encoded in the genome of the ectomycorrhizal Laccaria bicolor is linked to a glycoside hydrolase family 5 (GH5) endoglucanase, LbGH5-CBM1. Here, we characterize LbGH5-CBM1 gene expression and the biochemical properties of its protein product...
April 6, 2018: New Phytologist
https://www.readbyqxmd.com/read/29622887/ibrutinib-to-allogenic-stem-cell-transplant-in-a-case-of-refractory-mantle-cell-lymphoma
#10
Rayaz Ahmed, Jyotsna Kapoor, Narendra Agrawal, Priyanka Verma, Dinesh Bhurani
No abstract text is available yet for this article.
April 2018: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29619501/bendamustine-plus-rituximab-for-relapsed-or-refractory-diffuse-large-b-cell-lymphoma-a-multicenter-retrospective-analysis
#11
Jung Yong Hong, Dok Hyun Yoon, Cheolwon Suh, Won Seog Kim, Seok Jin Kim, Jae-Cheol Jo, Jin Seok Kim, Won-Sik Lee, Sung Yong Oh, Yong Park, Sung-Yong Kim, Mark Hong Lee, Ho Sup Lee, Young Rok Do
Bendamustine plus rituximab (BR) showed efficacy and safety in indolent lymphomas and mantle cell lymphoma. However, there were limited experiences of real-world practice of BR in diffuse large B cell lymphoma (DLBCL). In this study, we report the Korean experiences with BR in relapsed or refractory DLBCL who are not eligible for intensive chemotherapy and autologous stem cell transplantation. This is an observational, multicenter, retrospective analysis. Between December 2011 and December 2015, a total of 58 patients with relapsed or refractory DLBCL were treated with BR in 11 tertiary hospitals in Korea...
April 4, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29615403/sox11-augments-bcr-signaling-to-drive-mcl-like-tumor-development
#12
Pei-Yu Kuo, Shashidhar S Jatiani, Adeeb H Rahman, Donna Edwards, Zewei Jiang, Katya Ahr, Deepak Perumal, Violetta V Leshchenko, Joshua Brody, Rita Shaknovich, B Hilda Ye, Samir Parekh
Mantle cell lymphoma (MCL) is characterized by increased B-cell receptor (BCR) signaling and BTK inhibition is an effective therapeutic intervention in MCL patients. The mechanisms leading to increased BCR signaling in MCL are poorly understood, as mutations in upstream regulators of BCR signaling such as CD79A, commonly observed in other lymphomas, are rare in MCL. The transcription factor SOX11 is overexpressed in the majority (78-93%) of MCL patients and is considered an MCL-specific oncogene. So far, attempts to understand SOX11 function in vivo have been hampered by the lack of appropriate animal models; since germline deletion of SOX11 is embryonically lethal...
April 3, 2018: Blood
https://www.readbyqxmd.com/read/29610968/impact-of-hematopoietic-stem-cell-transplantation-in-patients-with-relapsed-or-refractory-mantle-cell-lymphoma
#13
Satoshi Yamasaki, Dai Chihara, Sung-Won Kim, Koji Izutsu, Kouji Iwato, Takahiro Fukuda, Naoyuki Uchida, Itsuto Amano, Hideyuki Nakazawa, Junya Kuroda, Hisako Hashimoto, Tatsuo Ichinohe, Yoshinobu Kanda, Yoshiko Atsuta, Junji Suzumiya, Ritsuro Suzuki
Rituximab has been shown to improve outcomes in patients with B-cell lymphoma. However, patients with relapsed or refractory (R/R) mantle cell lymphoma (MCL) still have a poor prognosis, and the choice between high-dose therapy with autologous hematopoietic cell transplantation (HCT) and allogeneic HCT remains controversial in these patients. We retrospectively analyzed the risk factors for outcomes in 162 R/R MCL patients who received autologous (n = 111) or allogeneic (n = 51) HCT between 2004 and 2014...
April 2, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29610319/effects-of-iron-on-the-lattice-thermal-conductivity-of-earth-s-deep-mantle-and-implications-for-mantle-dynamics
#14
Wen-Pin Hsieh, Frédéric Deschamps, Takuo Okuchi, Jung-Fu Lin
Iron may critically influence the physical properties and thermochemical structures of Earth's lower mantle. Its effects on thermal conductivity, with possible consequences on heat transfer and mantle dynamics, however, remain largely unknown. We measured the lattice thermal conductivity of lower-mantle ferropericlase to 120 GPa using the ultrafast optical pump-probe technique in a diamond anvil cell. The thermal conductivity of ferropericlase with 56% iron significantly drops by a factor of 1.8 across the spin transition around 53 GPa, while that with 8-10% iron increases monotonically with pressure, causing an enhanced iron substitution effect in the low-spin state...
April 2, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29603360/on-the-performance-of-adaptive-preprocessing-technique-in-analyzing-high-dimensional-censored-data
#15
Md Hasinur Rahaman Khan
Preprocessing for high-dimensional censored datasets, such as the microarray data, is generally considered as an important technique to gain further stability by reducing potential noise from the data. When variable selection including inference is carried out with high-dimensional censored data the objective is to obtain a smaller subset of variables and then perform the inferential analysis using model estimates based on the selected subset of variables. This two stage inferential analysis is prone to circularity bias because of the noise that might still remain in the dataset...
March 30, 2018: Biometrical Journal. Biometrische Zeitschrift
https://www.readbyqxmd.com/read/29596733/skin-barrier-in-the-neonate
#16
Alain Taïeb
The purpose of this review is to focus on determinants of skin barrier function in neonates at molecular and cellular levels. The skin barrier is critical in terms of water and gas exchanges during fetal life and undergoes rapid changes at birth, followed by a progressive maturation. Consequences of skin barrier disruption can be extremely detrimental or lethal, as shown in severe genetic epidermal defects. In this context, the fine-tuned rapid adaptation from a liquid to a gaseous milieu is not fully understood...
March 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29590547/ibrutinib-plus-venetoclax-for-the-treatment-of-mantle-cell-lymphoma
#17
COMPARATIVE STUDY
Constantine S Tam, Mary Ann Anderson, Christiane Pott, Rishu Agarwal, Sasanka Handunnetti, Rodney J Hicks, Kate Burbury, Gillian Turner, Juliana Di Iulio, Mathias Bressel, David Westerman, Stephen Lade, Martin Dreyling, Sarah-Jane Dawson, Mark A Dawson, John F Seymour, Andrew W Roberts
BACKGROUND: Both the BTK inhibitor ibrutinib and the BCL2 inhibitor venetoclax are active as monotherapy in the treatment of mantle-cell lymphoma. Complete response rates of 21% have been observed for each agent when administered as long-term continuous therapy. Preclinical models predict synergy in combination. METHODS: We conducted a single-group, phase 2 study of daily oral ibrutinib and venetoclax in patients, as compared with historical controls. Patients commenced ibrutinib monotherapy at a dose of 560 mg per day...
March 29, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29579328/complex-karyotype-in-patients-with-mantle-cell-lymphoma-predicts-inferior-survival-and-poor-response-to-intensive-induction-therapy
#18
I Brian Greenwell, Ashley D Staton, Michael J Lee, Jeffrey M Switchenko, Debra F Saxe, Joseph J Maly, Kristie A Blum, Natalie S Grover, Stephanie P Mathews, Max J Gordon, Alexey V Danilov, Narendranath Epperla, Timothy S Fenske, Mehdi Hamadani, Steven I Park, Christopher R Flowers, Jonathon B Cohen
BACKGROUND: Risk stratification of newly diagnosed patients with mantle cell lymphoma (MCL) primarily is based on the MCL International Prognostic Index (MIPI) and Ki-67 proliferative index. Single-center studies have reported inferior outcomes in patients with a complex karyotype (CK), but this remains an area of controversy. METHODS: The authors retrospectively reviewed 483 patients from 5 academic centers in the United States and described the effect of a CK on survival outcomes in individuals with MCL...
March 26, 2018: Cancer
https://www.readbyqxmd.com/read/29577189/effect-of-various-treatment-modes-of-experimental-mammary-gland-tumor-on-structure-of-anterior-mediastinal-lymph-nodes
#19
O V Kazakov, A V Kabakov, A F Poveshchenko, T V Raiter, D N Strunkin, S S Bogachev, I Yu Ishchenko, A P Lykov, S V Michurina, V I Konenkov
The effects of various treatment modes on the morphology of anterior mediastinal lymph nodes were examined in female Wistar rats with chemically provoked breast cancer. Adjuvant chemotherapy impaired filtration barrier potential of the anterior mediastinal lymph nodes, which manifested in increased volume of sinuses, reduced volumes of lymphoid nodules with germinal centers and thymus-dependent regions, down-regulated proliferative activity of lymphoid cells in B-cell zone and paracortex, and diminished macrophage score in all zones...
March 26, 2018: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29575238/additive-and-synergistic-inhibition-of-mantle-cell-lymphoma-cell-growth-by-combining-olaparib-with-ibrutinib
#20
Adam Curtis, Jens Rueter, Shelia Rajan, Rong Zhang, Lindsay Shopland
Mantle cell lymphoma (MCL) presents a therapeutic challenge. The B cell targeting agent, ibrutinib, is currently one of the most effective second-line therapies for MCL, but frequently leads to development of drug resistance, and short overall survival time upon relapse. Olaparib targets tumor cells with deficiencies in single-strand DNA break repair and thus may slow the development of genetic drug resistance. We found that the olaparib-ibrutinib combination significantly inhibits cell culture growth compared to either drug alone in two genetically distinct MCL cell lines...
March 25, 2018: Journal of Cellular Biochemistry
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