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https://www.readbyqxmd.com/read/27763941/analysis-of-patient-reported-outcomes-of-quality-of-life-and-functioning-before-and-after-treatment-of-major-depressive-disorder-comorbid-with-alcohol-use-disorders
#1
Itai Danovitch, Alexander Joseph Steiner, Anna Kazdan, Matthew Goldenberg, Margaret Haglund, James Mirocha, Katherine Collison, Brigitte Vanle, Jonathan Dang, Waguih William IsHak
OBJECTIVE: Alcohol use disorders (AUDs) are common among persons with major depressive disorder (MDD) and have an adverse impact on course of illness and patient outcomes. The aim of this study was to examine whether AUD adversely impacted patient-centered outcomes in a sample of research subjects evaluated as part of a large clinical trial for depression. The outcomes of interest to this post hoc analysis are quality of life (QOL), functioning, and depressive symptom severity. METHODS: We analyzed 2280 adult MDD outpatient research subjects using data from the Sequenced Treatment Alternatives to Relieve Depression trial...
October 18, 2016: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/27660855/discovery-of-orally-efficacious-phosphoinositide-3-kinase-%C3%AE-inhibitors-with-improved-metabolic-stability
#2
Leena Patel, Jayaraman Chandrasekhar, Jerry Evarts, Kristen Forseth, Aaron C Haran, Carmen Ip, Adam Kashishian, Musong Kim, David Koditek, Sandy Koppenol, Latesh Lad, Eve-Irene Lepist, Mary E McGrath, Stephane Perreault, Kamal D Puri, Armando G Villaseñor, John R Somoza, Bart H Steiner, Joseph Therrien, Jennifer Treiberg, Gary Phillips
Aberrant signaling of phosphoinositide 3-kinase δ (PI3Kδ) has been implicated in numerous pathologies including hematological malignancies and rheumatoid arthritis. Described in this manuscript are the discovery, optimization, and in vivo evaluation of a novel series of pyridine-containing PI3Kδ inhibitors. This work led to the discovery of 35, a highly selective inhibitor of PI3Kδ which displays an excellent pharmacokinetic profile and is efficacious in a rodent model of rheumatoid arthritis.
October 3, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27630261/the-interaction-of-munc-18-p67-with-the-p10-domain-of-p35-protects-in-vivo-cdk5-p35-activity-from-inhibition-by-tfp5-a-peptide-derived-from-p35
#3
Niranjana D Amin, Yali Zheng, Binukumar Bk, Varsha Shukla, Susan Skuntz, Philip Grant, Joseph Steiner, Manju Bhaskar, Harish C Pant
In a series of studies, we have identified TFP5, a truncated fragment of p35, the Cdk5 kinase regulatory protein, that inhibits Cdk5/p35 and the hyperactive Cdk5/p25 activities in test tube experiments. In cortical neurons, however, and in vivo in AD model mice, the peptide specifically inhibits the Cdk5/p25 complex and not the endogenous Cdk5/p35. To account for the selective inhibition of Cdk5/p25 activity, we propose that the "p10" N-terminal domain of p35, absent in p25, spares Cdk5/p35 because p10 binds to macromolecules (e...
September 14, 2016: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/27624634/a-nationwide-assessment-of-the-association-of-smoking-bans-and-cigarette-taxes-with-hospitalizations-for-acute-myocardial-infarction-heart-failure-and-pneumonia
#4
Vivian Ho, Joseph S Ross, Claudia A Steiner, Aditya Mandawat, Marah Short, Meei-Hsiang Ku-Goto, Harlan M Krumholz
Multiple studies claim that public place smoking bans are associated with reductions in smoking-related hospitalization rates. No national study using complete hospitalization counts by area that accounts for contemporaneous controls including state cigarette taxes has been conducted. We examine the association between county-level smoking-related hospitalization rates and comprehensive smoking bans in 28 states from 2001 to 2008. Differences-in-differences analysis measures changes in hospitalization rates before versus after introducing bans in bars, restaurants, and workplaces, controlling for cigarette taxes, adjusting for local health and provider characteristics...
September 12, 2016: Medical Care Research and Review: MCRR
https://www.readbyqxmd.com/read/27579595/relationship-between-inflammatory-biomarkers-and-depressive-symptoms-during-late-pregnancy-and-the-early-postpartum-period-a-longitudinal-study
#5
William Simpson, Meir Steiner, Marg Coote, Benicio N Frey
OBJECTIVE: Perinatal depressive symptoms often co-occur with other inflammatory morbidities of pregnancy. The goals of our study were 1) to examine whether changes in inflammatory markers from the third trimester of pregnancy to 12 weeks postpartum were associated with changes in depressive symptoms; 2) to examine whether third trimester inflammatory markers alone were predictive of postpartum depressive symptoms; and 3) to examine the relationship between inflammatory markers and depressive symptoms during the third trimester of pregnancy and at 12 weeks postpartum...
July 2016: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/27568068/health-in-times-of-uncertainty-in-the-eastern-mediterranean-region-1990-2013-a-systematic-analysis-for-the-global-burden-of-disease-study-2013
#6
Ali H Mokdad, Mohammad Hossein Forouzanfar, Farah Daoud, Charbel El Bcheraoui, Maziar Moradi-Lakeh, Ibrahim Khalil, Ashkan Afshin, Marwa Tuffaha, Raghid Charara, Ryan M Barber, Joseph Wagner, Kelly Cercy, Hannah Kravitz, Matthew M Coates, Margaret Robinson, Kara Estep, Caitlyn Steiner, Sara Jaber, Ali A Mokdad, Kevin F O'Rourke, Adrienne Chew, Pauline Kim, Mohamed Magdy Abd El Razek, Safa Abdalla, Foad Abd-Allah, Jerry P Abraham, Laith J Abu-Raddad, Niveen M E Abu-Rmeileh, Abdulwahab A Al-Nehmi, Ali S Akanda, Hanan Al Ahmadi, Mazin J Al Khabouri, Faris H Al Lami, Zulfa A Al Rayess, Deena Alasfoor, Fadia S AlBuhairan, Saleh F Aldhahri, Suliman Alghnam, Samia Alhabib, Nawal Al-Hamad, Raghib Ali, Syed Danish Ali, Mohammad Alkhateeb, Mohammad A AlMazroa, Mahmoud A Alomari, Rajaa Al-Raddadi, Ubai Alsharif, Nihaya Al-Sheyab, Shirina Alsowaidi, Mohamed Al-Thani, Khalid A Altirkawi, Azmeraw T Amare, Heresh Amini, Walid Ammar, Palwasha Anwari, Hamid Asayesh, Rana Asghar, Ali M Assabri, Reza Assadi, Umar Bacha, Alaa Badawi, Talal Bakfalouni, Mohammed O Basulaiman, Shahrzad Bazargan-Hejazi, Neeraj Bedi, Amit R Bhakta, Zulfiqar A Bhutta, Aref A Bin Abdulhak, Soufiane Boufous, Rupert R A Bourne, Hadi Danawi, Jai Das, Amare Deribew, Eric L Ding, Adnan M Durrani, Yousef Elshrek, Mohamed E Ibrahim, Babak Eshrati, Alireza Esteghamati, Imad A D Faghmous, Farshad Farzadfar, Andrea B Feigl, Seyed-Mohammad Fereshtehnejad, Irina Filip, Florian Fischer, Fortuné G Gankpé, Ibrahim Ginawi, Melkamu Dedefo Gishu, Rahul Gupta, Rami M Habash, Nima Hafezi-Nejad, Randah R Hamadeh, Hayet Hamdouni, Samer Hamidi, Hilda L Harb, Mohammad Sadegh Hassanvand, Mohammad T Hedayati, Pouria Heydarpour, Mohamed Hsairi, Abdullatif Husseini, Nader Jahanmehr, Vivekanand Jha, Jost B Jonas, Nadim E Karam, Amir Kasaeian, Nega Assefa Kassa, Anil Kaul, Yousef Khader, Shams Eldin A Khalifa, Ejaz A Khan, Gulfaraz Khan, Tawfik Khoja, Ardeshir Khosravi, Yohannes Kinfu, Barthelemy Kuate Defo, Arjun Lakshmana Balaji, Raimundas Lunevicius, Carla Makhlouf Obermeyer, Reza Malekzadeh, Morteza Mansourian, Wagner Marcenes, Habibolah Masoudi Farid, Alem Mehari, Abla Mehio-Sibai, Ziad A Memish, George A Mensah, Karzan A Mohammad, Ziad Nahas, Jamal T Nasher, Haseeb Nawaz, Chakib Nejjari, Muhammad Imran Nisar, Saad B Omer, Mahboubeh Parsaeian, Emmanuel K Peprah, Aslam Pervaiz, Farshad Pourmalek, Dima M Qato, Mostafa Qorbani, Amir Radfar, Anwar Rafay, Kazem Rahimi, Vafa Rahimi-Movaghar, Sajjad Ur Rahman, Rajesh K Rai, Saleem M Rana, Sowmya R Rao, Amany H Refaat, Serge Resnikoff, Gholamreza Roshandel, Georges Saade, Mohammad Y Saeedi, Mohammad Ali Sahraian, Shadi Saleh, Lidia Sanchez-Riera, Maheswar Satpathy, Sadaf G Sepanlou, Tesfaye Setegn, Amira Shaheen, Saeid Shahraz, Sara Sheikhbahaei, Kawkab Shishani, Karen Sliwa, Mohammad Tavakkoli, Abdullah S Terkawi, Olalekan A Uthman, Ronny Westerman, Mustafa Z Younis, Maysaa El Sayed Zaki, Faiez Zannad, Gregory A Roth, Haidong Wang, Mohsen Naghavi, Theo Vos, Abdullah A Al Rabeeah, Alan D Lopez, Christopher J L Murray
BACKGROUND: The eastern Mediterranean region is comprised of 22 countries: Afghanistan, Bahrain, Djibouti, Egypt, Iran, Iraq, Jordan, Kuwait, Lebanon, Libya, Morocco, Oman, Pakistan, Palestine, Qatar, Saudi Arabia, Somalia, Sudan, Syria, Tunisia, the United Arab Emirates, and Yemen. Since our Global Burden of Disease Study 2010 (GBD 2010), the region has faced unrest as a result of revolutions, wars, and the so-called Arab uprisings. The objective of this study was to present the burden of diseases, injuries, and risk factors in the eastern Mediterranean region as of 2013...
October 2016: Lancet Global Health
https://www.readbyqxmd.com/read/27567857/profiling-of-p5-a-24-amino-acid-inhibitory-peptide-derived-from-the-cdk5-activator-p35-cdkr1-against-70-protein-kinases
#7
B K Binukumar, Steven L Pelech, Catherine Sutter, Varsha Shukla, Niranjana D Amin, Philip Grant, Manju Bhaskar, Suzanne Skuntz, Joseph Steiner, Harish C Pant
Cyclin-dependent kinase 5 (CDK5) is a multifunctional serine/threonine kinase that regulates a large number of neuronal processes essential for nervous system development and function with its activator p35 CDK5R1. Upon neuronal insults, p35 is proteolyzed and cleaved to p25 producing deregulation and hyperactivation of CDK5 (CDK5/p25), implicated in tau hyperphosphorylation, a pathology in some neurodegenerative diseases. A truncated, 24 amino acid peptide, p5, derived from p35 inhibits the deregulated CDK5 phosphotransferase activity and ameliorates Alzheimer's disease (AD) phenotypes in AD model mice...
September 6, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27520715/soft-tissue-norms-conventional-and-based-on-true-vertical-in-a-lebanese-population
#8
Emilie El Hayeck, Nayla Bassil-Nassif, Joseph Bouserhal
INTRODUCTION: The aim of this study was to establish cephalometric soft tissue norms in a Lebanese population of young adults and profile differences between males and females. MATERIALS AND METHODS: Ninety subjects divided into 43 women and 47 men, aged from 18 to 30 years, were selected based on specific criteria. The lateral cephalograms were taken in the natural head position. Holdaway, Steiner, Merrifield, Ricketts, Epker and Fish analyses were applied as conventional analyses...
September 2016: International Orthodontics
https://www.readbyqxmd.com/read/27174305/global-burden-of-diseases-injuries-and-risk-factors-for-young-people-s-health-during-1990-2013-a-systematic-analysis-for-the-global-burden-of-disease-study-2013
#9
Ali H Mokdad, Mohammad Hossein Forouzanfar, Farah Daoud, Arwa A Mokdad, Charbel El Bcheraoui, Maziar Moradi-Lakeh, Hmwe Hmwe Kyu, Ryan M Barber, Joseph Wagner, Kelly Cercy, Hannah Kravitz, Megan Coggeshall, Adrienne Chew, Kevin F O'Rourke, Caitlyn Steiner, Marwa Tuffaha, Raghid Charara, Essam Abdullah Al-Ghamdi, Yaser Adi, Rima A Afifi, Hanan Alahmadi, Fadia AlBuhairan, Nicholas Allen, Mohammad AlMazroa, Abdulwahab A Al-Nehmi, Zulfa AlRayess, Monika Arora, Peter Azzopardi, Carmen Barroso, Mohammed Basulaiman, Zulfiqar A Bhutta, Chris Bonell, Cecilia Breinbauer, Louisa Degenhardt, Donna Denno, Jing Fang, Adesegun Fatusi, Andrea B Feigl, Ritsuko Kakuma, Nadim Karam, Elissa Kennedy, Tawfik A M Khoja, Fadi Maalouf, Carla Makhlouf Obermeyer, Amitabh Mattoo, Terry McGovern, Ziad A Memish, George A Mensah, Vikram Patel, Suzanne Petroni, Nicola Reavley, Diego Rios Zertuche, Mohammad Saeedi, John Santelli, Susan M Sawyer, Fred Ssewamala, Kikelomo Taiwo, Muhammad Tantawy, Russell M Viner, Jane Waldfogel, Maria Paola Zuñiga, Mohsen Naghavi, Haidong Wang, Theo Vos, Alan D Lopez, Abdullah A Al Rabeeah, George C Patton, Christopher J L Murray
BACKGROUND: Young people's health has emerged as a neglected yet pressing issue in global development. Changing patterns of young people's health have the potential to undermine future population health as well as global economic development unless timely and effective strategies are put into place. We report the past, present, and anticipated burden of disease in young people aged 10-24 years from 1990 to 2013 using data on mortality, disability, injuries, and health risk factors. METHODS: The Global Burden of Disease Study 2013 (GBD 2013) includes annual assessments for 188 countries from 1990 to 2013, covering 306 diseases and injuries, 1233 sequelae, and 79 risk factors...
June 11, 2016: Lancet
https://www.readbyqxmd.com/read/27092852/the-community-preceptor-crisis-recruiting-and-retaining-community-based-faculty-to-teach-medical-students-a-shared-perspective-from-the-alliance-for-clinical-education
#10
Jennifer G Christner, Gary Beck Dallaghan, Gregory Briscoe, Petra Casey, Ruth Marie E Fincher, Lynn M Manfred, Katherine I Margo, Peter Muscarella, Joshua E Richardson, Joseph Safdieh, Beat D Steiner
ISSUE: Community-based instruction is invaluable to medical students, as it provides "real-world" opportunities for observing and following patients over time while refining history taking, physical examination, differential diagnosis, and patient management skills. Community-based ambulatory settings can be more conducive to practicing these skills than highly specialized, academically based practice sites. The Association of American Medical Colleges and other national medical education organizations have expressed concern about recruitment and retention of preceptors to provide high-quality educational experiences in community-based practice sites...
July 2016: Teaching and Learning in Medicine
https://www.readbyqxmd.com/read/27071622/pathogenetics-of-alveolar-capillary-dysplasia-with-misalignment-of-pulmonary-veins
#11
Przemyslaw Szafranski, Tomasz Gambin, Avinash V Dharmadhikari, Kadir Caner Akdemir, Shalini N Jhangiani, Jennifer Schuette, Nihal Godiwala, Svetlana A Yatsenko, Jessica Sebastian, Suneeta Madan-Khetarpal, Urvashi Surti, Rosanna G Abellar, David A Bateman, Ashley L Wilson, Melinda H Markham, Jill Slamon, Fernando Santos-Simarro, María Palomares, Julián Nevado, Pablo Lapunzina, Brian Hon-Yin Chung, Wai-Lap Wong, Yoyo Wing Yiu Chu, Gary Tsz Kin Mok, Eitan Kerem, Joel Reiter, Namasivayam Ambalavanan, Scott A Anderson, David R Kelly, Joseph Shieh, Taryn C Rosenthal, Kristin Scheible, Laurie Steiner, M Anwar Iqbal, Margaret L McKinnon, Sara Jane Hamilton, Kamilla Schlade-Bartusiak, Dawn English, Glenda Hendson, Elizabeth R Roeder, Thomas S DeNapoli, Rebecca Okashah Littlejohn, Daynna J Wolff, Carol L Wagner, Alison Yeung, David Francis, Elizabeth K Fiorino, Morris Edelman, Joyce Fox, Denise A Hayes, Sandra Janssens, Elfride De Baere, Björn Menten, Anne Loccufier, Lieve Vanwalleghem, Philippe Moerman, Yves Sznajer, Amy S Lay, Jennifer L Kussmann, Jasneek Chawla, Diane J Payton, Gael E Phillips, Erwin Brosens, Dick Tibboel, Annelies de Klein, Isabelle Maystadt, Richard Fisher, Neil Sebire, Alison Male, Maya Chopra, Jason Pinner, Girvan Malcolm, Gregory Peters, Susan Arbuckle, Melissa Lees, Zoe Mead, Oliver Quarrell, Richard Sayers, Martina Owens, Charles Shaw-Smith, Janet Lioy, Eileen McKay, Nicole de Leeuw, Ilse Feenstra, Liesbeth Spruijt, Frances Elmslie, Timothy Thiruchelvam, Carlos A Bacino, Claire Langston, James R Lupski, Partha Sen, Edwina Popek, Paweł Stankiewicz
Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a lethal lung developmental disorder caused by heterozygous point mutations or genomic deletion copy-number variants (CNVs) of FOXF1 or its upstream enhancer involving fetal lung-expressed long noncoding RNA genes LINC01081 and LINC01082. Using custom-designed array comparative genomic hybridization, Sanger sequencing, whole exome sequencing (WES), and bioinformatic analyses, we studied 22 new unrelated families (20 postnatal and two prenatal) with clinically diagnosed ACDMPV...
May 2016: Human Genetics
https://www.readbyqxmd.com/read/26980109/2-4-6-triaminopyrimidine-as-a-novel-hinge-binder-in-a-series-of-pi3k%C3%AE-selective-inhibitors
#12
Leena Patel, Jayaraman Chandrasekhar, Jerry Evarts, Aaron C Haran, Carmen Ip, Joshua A Kaplan, Musong Kim, David Koditek, Latesh Lad, Eve-Irene Lepist, Mary E McGrath, Nikolai Novikov, Stephane Perreault, Kamal D Puri, John R Somoza, Bart H Steiner, Kirk L Stevens, Joseph Therrien, Jennifer Treiberg, Armando G Villaseñor, Arthur Yeung, Gary Phillips
Inhibition of phosphoinositide 3-kinase δ (PI3Kδ) is an appealing target for several hematological malignancies and inflammatory diseases. Herein, we describe the discovery and optimization of a series of propeller shaped PI3Kδ inhibitors comprising a novel triaminopyrimidine hinge binder. Combinations of electronic and structural strategies were employed to mitigate aldehyde oxidase mediated metabolism. This medicinal chemistry effort culminated in the identification of 52, a potent and highly selective inhibitor of PI3Kδ that demonstrates efficacy in a rat model of arthritis...
April 14, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/26967775/aneurysm-growth-and-de-novo-aneurysms-during-aneurysm-surveillance
#13
Joseph C Serrone, Ryan D Tackla, Yair M Gozal, Dennis J Hanseman, Steven L Gogela, Shawn M Vuong, Jennifer A Kosty, Calen A Steiner, Bryan M Krueger, Aaron W Grossman, Andrew J Ringer
OBJECTIVE Many low-risk unruptured intracranial aneurysms (UIAs) are followed for growth with surveillance imaging. Growth of UIAs likely increases the risk of rupture. The incidence and risk factors of UIA growth or de novo aneurysm formation require further research. The authors retrospectively identify risk factors and annual risk for UIA growth or de novo aneurysm formation in an aneurysm surveillance protocol. METHODS Over an 11.5-year period, the authors recommended surveillance imaging to 192 patients with 234 UIAs...
December 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/26810619/global-and-national-burden-of-diseases-and-injuries-among-children-and-adolescents-between-1990-and-2013-findings-from-the-global-burden-of-disease-2013-study
#14
Hmwe H Kyu, Christine Pinho, Joseph A Wagner, Jonathan C Brown, Amelia Bertozzi-Villa, Fiona J Charlson, Luc Edgar Coffeng, Lalit Dandona, Holly E Erskine, Alize J Ferrari, Christina Fitzmaurice, Thomas D Fleming, Mohammad H Forouzanfar, Nicholas Graetz, Caterina Guinovart, Juanita Haagsma, Hideki Higashi, Nicholas J Kassebaum, Heidi J Larson, Stephen S Lim, Ali H Mokdad, Maziar Moradi-Lakeh, Shaun V Odell, Gregory A Roth, Peter T Serina, Jeffrey D Stanaway, Awoke Misganaw, Harvey A Whiteford, Timothy M Wolock, Sarah Wulf Hanson, Foad Abd-Allah, Semaw Ferede Abera, Laith J Abu-Raddad, Fadia S AlBuhairan, Azmeraw T Amare, Carl Abelardo T Antonio, Al Artaman, Suzanne L Barker-Collo, Lope H Barrero, Corina Benjet, Isabela M Bensenor, Zulfiqar A Bhutta, Boris Bikbov, Alexandra Brazinova, Ismael Campos-Nonato, Carlos A Castañeda-Orjuela, Ferrán Catalá-López, Rajiv Chowdhury, Cyrus Cooper, John A Crump, Rakhi Dandona, Louisa Degenhardt, Robert P Dellavalle, Samath D Dharmaratne, Emerito Jose A Faraon, Valery L Feigin, Thomas Fürst, Johanna M Geleijnse, Bradford D Gessner, Katherine B Gibney, Atsushi Goto, David Gunnell, Graeme J Hankey, Roderick J Hay, John C Hornberger, H Dean Hosgood, Guoqing Hu, Kathryn H Jacobsen, Sudha P Jayaraman, Panniyammakal Jeemon, Jost B Jonas, André Karch, Daniel Kim, Sungroul Kim, Yoshihiro Kokubo, Barthelemy Kuate Defo, Burcu Kucuk Bicer, G Anil Kumar, Anders Larsson, Janet L Leasher, Ricky Leung, Yongmei Li, Steven E Lipshultz, Alan D Lopez, Paulo A Lotufo, Raimundas Lunevicius, Ronan A Lyons, Marek Majdan, Reza Malekzadeh, Taufiq Mashal, Amanda J Mason-Jones, Yohannes Adama Melaku, Ziad A Memish, Walter Mendoza, Ted R Miller, Charles N Mock, Joseph Murray, Sandra Nolte, In-Hwan Oh, Bolajoko Olubukunola Olusanya, Katrina F Ortblad, Eun-Kee Park, Angel J Paternina Caicedo, Scott B Patten, George C Patton, David M Pereira, Norberto Perico, Frédéric B Piel, Suzanne Polinder, Svetlana Popova, Farshad Pourmalek, D Alex Quistberg, Giuseppe Remuzzi, Alina Rodriguez, David Rojas-Rueda, Dietrich Rothenbacher, David H Rothstein, Juan Sanabria, Itamar S Santos, David C Schwebel, Sadaf G Sepanlou, Amira Shaheen, Rahman Shiri, Ivy Shiue, Vegard Skirbekk, Karen Sliwa, Chandrashekhar T Sreeramareddy, Dan J Stein, Timothy J Steiner, Lars Jacob Stovner, Bryan L Sykes, Karen M Tabb, Abdullah Sulieman Terkawi, Alan J Thomson, Andrew L Thorne-Lyman, Jeffrey Allen Towbin, Kingsley Nnanna Ukwaja, Tommi Vasankari, Narayanaswamy Venketasubramanian, Vasiliy Victorovich Vlassov, Stein Emil Vollset, Elisabete Weiderpass, Robert G Weintraub, Andrea Werdecker, James D Wilkinson, Solomon Meseret Woldeyohannes, Charles D A Wolfe, Yuichiro Yano, Paul Yip, Naohiro Yonemoto, Seok-Jun Yoon, Mustafa Z Younis, Chuanhua Yu, Maysaa El Sayed Zaki, Mohsen Naghavi, Christopher J L Murray, Theo Vos
IMPORTANCE: The literature focuses on mortality among children younger than 5 years. Comparable information on nonfatal health outcomes among these children and the fatal and nonfatal burden of diseases and injuries among older children and adolescents is scarce. OBJECTIVE: To determine levels and trends in the fatal and nonfatal burden of diseases and injuries among younger children (aged <5 years), older children (aged 5-9 years), and adolescents (aged 10-19 years) between 1990 and 2013 in 188 countries from the Global Burden of Disease (GBD) 2013 study...
March 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/26692391/erratum-to-interaction-of-paroxetine-with-mitochondrial-proteins-mediates-neuroprotection
#15
Joseph P Steiner, Muznabanu Bachani, Brett Wolfson-Stofko, Myoung-Hwa Lee, Tongguang Wang, Guanhan Li, Wenxue Li, David Strayer, Norman J Haughey, Avindra Nath
No abstract text is available yet for this article.
January 2016: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/26444778/analysis-of-the-inhibitory-elements-in-the-p5-peptide-fragment-of-the-cdk5-activator-p35-cdkr1-protein
#16
B K Binukumar, Varsha Shukla, Niranjana D Amin, Manju Bhaskar, Suzanne Skuntz, Joseph Steiner, Dirk Winkler, Steven L Pelech, Harish C Pant
Besides the hallmark pathology of amyloid plaques and neurofibrillary tangles, it is well documented that cyclin-dependent kinase 5 (CDK5), a critical neuronal protein kinase in nervous system development, function, and survival, when deregulated and hyperactivated induces Alzheimer's disease (AD) and amyotrophic lateral sclerosis and Parkinson's disease-like phenotypes in mice. In a recent study, we demonstrated that p5, a small, truncated fragment of 24 amino acid residues derived from the CDK5 activator protein 35 (NCK5A, p35), selectively inhibited deregulated CDK5 hyperactivity and ameliorated AD phenotypes in model mice...
2015: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/26321261/global-regional-and-national-disability-adjusted-life-years-dalys-for-306-diseases-and-injuries-and-healthy-life-expectancy-hale-for-188-countries-1990-2013-quantifying-the-epidemiological-transition
#17
Christopher J L Murray, Ryan M Barber, Kyle J Foreman, Ayse Abbasoglu Ozgoren, Foad Abd-Allah, Semaw F Abera, Victor Aboyans, Jerry P Abraham, Ibrahim Abubakar, Laith J Abu-Raddad, Niveen M Abu-Rmeileh, Tom Achoki, Ilana N Ackerman, Zanfina Ademi, Arsène K Adou, José C Adsuar, Ashkan Afshin, Emilie E Agardh, Sayed Saidul Alam, Deena Alasfoor, Mohammed I Albittar, Miguel A Alegretti, Zewdie A Alemu, Rafael Alfonso-Cristancho, Samia Alhabib, Raghib Ali, François Alla, Peter Allebeck, Mohammad A Almazroa, Ubai Alsharif, Elena Alvarez, Nelson Alvis-Guzman, Azmeraw T Amare, Emmanuel A Ameh, Heresh Amini, Walid Ammar, H Ross Anderson, Benjamin O Anderson, Carl Abelardo T Antonio, Palwasha Anwari, Johan Arnlöv, Valentina S Arsic Arsenijevic, Al Artaman, Rana J Asghar, Reza Assadi, Lydia S Atkins, Marco A Avila, Baffour Awuah, Victoria F Bachman, Alaa Badawi, Maria C Bahit, Kalpana Balakrishnan, Amitava Banerjee, Suzanne L Barker-Collo, Simon Barquera, Lars Barregard, Lope H Barrero, Arindam Basu, Sanjay Basu, Mohammed O Basulaiman, Justin Beardsley, Neeraj Bedi, Ettore Beghi, Tolesa Bekele, Michelle L Bell, Corina Benjet, Derrick A Bennett, Isabela M Bensenor, Habib Benzian, Eduardo Bernabé, Amelia Bertozzi-Villa, Tariku J Beyene, Neeraj Bhala, Ashish Bhalla, Zulfiqar A Bhutta, Kelly Bienhoff, Boris Bikbov, Stan Biryukov, Jed D Blore, Christopher D Blosser, Fiona M Blyth, Megan A Bohensky, Ian W Bolliger, Berrak Bora Başara, Natan M Bornstein, Dipan Bose, Soufiane Boufous, Rupert R A Bourne, Lindsay N Boyers, Michael Brainin, Carol E Brayne, Alexandra Brazinova, Nicholas J K Breitborde, Hermann Brenner, Adam D Briggs, Peter M Brooks, Jonathan C Brown, Traolach S Brugha, Rachelle Buchbinder, Geoffrey C Buckle, Christine M Budke, Anne Bulchis, Andrew G Bulloch, Ismael R Campos-Nonato, Hélène Carabin, Jonathan R Carapetis, Rosario Cárdenas, David O Carpenter, Valeria Caso, Carlos A Castañeda-Orjuela, Ruben E Castro, Ferrán Catalá-López, Fiorella Cavalleri, Alanur Çavlin, Vineet K Chadha, Jung-Chen Chang, Fiona J Charlson, Honglei Chen, Wanqing Chen, Peggy P Chiang, Odgerel Chimed-Ochir, Rajiv Chowdhury, Hanne Christensen, Costas A Christophi, Massimo Cirillo, Matthew M Coates, Luc E Coffeng, Megan S Coggeshall, Valentina Colistro, Samantha M Colquhoun, Graham S Cooke, Cyrus Cooper, Leslie T Cooper, Luis M Coppola, Monica Cortinovis, Michael H Criqui, John A Crump, Lucia Cuevas-Nasu, Hadi Danawi, Lalit Dandona, Rakhi Dandona, Emily Dansereau, Paul I Dargan, Gail Davey, Adrian Davis, Dragos V Davitoiu, Anand Dayama, Diego De Leo, Louisa Degenhardt, Borja Del Pozo-Cruz, Robert P Dellavalle, Kebede Deribe, Sarah Derrett, Don C Des Jarlais, Muluken Dessalegn, Samath D Dharmaratne, Mukesh K Dherani, Cesar Diaz-Torné, Daniel Dicker, Eric L Ding, Klara Dokova, E Ray Dorsey, Tim R Driscoll, Leilei Duan, Herbert C Duber, Beth E Ebel, Karen M Edmond, Yousef M Elshrek, Matthias Endres, Sergey P Ermakov, Holly E Erskine, Babak Eshrati, Alireza Esteghamati, Kara Estep, Emerito Jose A Faraon, Farshad Farzadfar, Derek F Fay, Valery L Feigin, David T Felson, Seyed-Mohammad Fereshtehnejad, Jefferson G Fernandes, Alize J Ferrari, Christina Fitzmaurice, Abraham D Flaxman, Thomas D Fleming, Nataliya Foigt, Mohammad H Forouzanfar, F Gerry R Fowkes, Urbano Fra Paleo, Richard C Franklin, Thomas Fürst, Belinda Gabbe, Lynne Gaffikin, Fortuné G Gankpé, Johanna M Geleijnse, Bradford D Gessner, Peter Gething, Katherine B Gibney, Maurice Giroud, Giorgia Giussani, Hector Gomez Dantes, Philimon Gona, Diego González-Medina, Richard A Gosselin, Carolyn C Gotay, Atsushi Goto, Hebe N Gouda, Nicholas Graetz, Harish C Gugnani, Rahul Gupta, Rajeev Gupta, Reyna A Gutiérrez, Juanita Haagsma, Nima Hafezi-Nejad, Holly Hagan, Yara A Halasa, Randah R Hamadeh, Hannah Hamavid, Mouhanad Hammami, Jamie Hancock, Graeme J Hankey, Gillian M Hansen, Yuantao Hao, Hilda L Harb, Josep Maria Haro, Rasmus Havmoeller, Simon I Hay, Roderick J Hay, Ileana B Heredia-Pi, Kyle R Heuton, Pouria Heydarpour, Hideki Higashi, Martha Hijar, Hans W Hoek, Howard J Hoffman, H Dean Hosgood, Mazeda Hossain, Peter J Hotez, Damian G Hoy, Mohamed Hsairi, Guoqing Hu, Cheng Huang, John J Huang, Abdullatif Husseini, Chantal Huynh, Marissa L Iannarone, Kim M Iburg, Kaire Innos, Manami Inoue, Farhad Islami, Kathryn H Jacobsen, Deborah L Jarvis, Simerjot K Jassal, Sun Ha Jee, Panniyammakal Jeemon, Paul N Jensen, Vivekanand Jha, Guohong Jiang, Ying Jiang, Jost B Jonas, Knud Juel, Haidong Kan, André Karch, Corine K Karema, Chante Karimkhani, Ganesan Karthikeyan, Nicholas J Kassebaum, Anil Kaul, Norito Kawakami, Konstantin Kazanjan, Andrew H Kemp, Andre P Kengne, Andre Keren, Yousef S Khader, Shams Eldin A Khalifa, Ejaz A Khan, Gulfaraz Khan, Young-Ho Khang, Christian Kieling, Daniel Kim, Sungroul Kim, Yunjin Kim, Yohannes Kinfu, Jonas M Kinge, Miia Kivipelto, Luke D Knibbs, Ann Kristin Knudsen, Yoshihiro Kokubo, Soewarta Kosen, Sanjay Krishnaswami, Barthelemy Kuate Defo, Burcu Kucuk Bicer, Ernst J Kuipers, Chanda Kulkarni, Veena S Kulkarni, G Anil Kumar, Hmwe H Kyu, Taavi Lai, Ratilal Lalloo, Tea Lallukka, Hilton Lam, Qing Lan, Van C Lansingh, Anders Larsson, Alicia E B Lawrynowicz, Janet L Leasher, James Leigh, Ricky Leung, Carly E Levitz, Bin Li, Yichong Li, Yongmei Li, Stephen S Lim, Maggie Lind, Steven E Lipshultz, Shiwei Liu, Yang Liu, Belinda K Lloyd, Katherine T Lofgren, Giancarlo Logroscino, Katharine J Looker, Joannie Lortet-Tieulent, Paulo A Lotufo, Rafael Lozano, Robyn M Lucas, Raimundas Lunevicius, Ronan A Lyons, Stefan Ma, Michael F Macintyre, Mark T Mackay, Marek Majdan, Reza Malekzadeh, Wagner Marcenes, David J Margolis, Christopher Margono, Melvin B Marzan, Joseph R Masci, Mohammad T Mashal, Richard Matzopoulos, Bongani M Mayosi, Tasara T Mazorodze, Neil W Mcgill, John J Mcgrath, Martin Mckee, Abigail Mclain, Peter A Meaney, Catalina Medina, Man Mohan Mehndiratta, Wubegzier Mekonnen, Yohannes A Melaku, Michele Meltzer, Ziad A Memish, George A Mensah, Atte Meretoja, Francis A Mhimbira, Renata Micha, Ted R Miller, Edward J Mills, Philip B Mitchell, Charles N Mock, Norlinah Mohamed Ibrahim, Karzan A Mohammad, Ali H Mokdad, Glen L D Mola, Lorenzo Monasta, Julio C Montañez Hernandez, Marcella Montico, Thomas J Montine, Meghan D Mooney, Ami R Moore, Maziar Moradi-Lakeh, Andrew E Moran, Rintaro Mori, Joanna Moschandreas, Wilkister N Moturi, Madeline L Moyer, Dariush Mozaffarian, William T Msemburi, Ulrich O Mueller, Mitsuru Mukaigawara, Erin C Mullany, Michele E Murdoch, Joseph Murray, Kinnari S Murthy, Mohsen Naghavi, Aliya Naheed, Kovin S Naidoo, Luigi Naldi, Devina Nand, Vinay Nangia, K M Venkat Narayan, Chakib Nejjari, Sudan P Neupane, Charles R Newton, Marie Ng, Frida N Ngalesoni, Grant Nguyen, Muhammad I Nisar, Sandra Nolte, Ole F Norheim, Rosana E Norman, Bo Norrving, Luke Nyakarahuka, In-Hwan Oh, Takayoshi Ohkubo, Summer L Ohno, Bolajoko O Olusanya, John Nelson Opio, Katrina Ortblad, Alberto Ortiz, Amanda W Pain, Jeyaraj D Pandian, Carlo Irwin A Panelo, Christina Papachristou, Eun-Kee Park, Jae-Hyun Park, Scott B Patten, George C Patton, Vinod K Paul, Boris I Pavlin, Neil Pearce, David M Pereira, Rogelio Perez-Padilla, Fernando Perez-Ruiz, Norberto Perico, Aslam Pervaiz, Konrad Pesudovs, Carrie B Peterson, Max Petzold, Michael R Phillips, Bryan K Phillips, David E Phillips, Frédéric B Piel, Dietrich Plass, Dan Poenaru, Suzanne Polinder, Daniel Pope, Svetlana Popova, Richie G Poulton, Farshad Pourmalek, Dorairaj Prabhakaran, Noela M Prasad, Rachel L Pullan, Dima M Qato, D Alex Quistberg, Anwar Rafay, Kazem Rahimi, Sajjad U Rahman, Murugesan Raju, Saleem M Rana, Homie Razavi, K Srinath Reddy, Amany Refaat, Giuseppe Remuzzi, Serge Resnikoff, Antonio L Ribeiro, Lee Richardson, Jan Hendrik Richardus, D Allen Roberts, David Rojas-Rueda, Luca Ronfani, Gregory A Roth, Dietrich Rothenbacher, David H Rothstein, Jane T Rowley, Nobhojit Roy, George M Ruhago, Mohammad Y Saeedi, Sukanta Saha, Mohammad Ali Sahraian, Uchechukwu K A Sampson, Juan R Sanabria, Logan Sandar, Itamar S Santos, Maheswar Satpathy, Monika Sawhney, Peter Scarborough, Ione J Schneider, Ben Schöttker, Austin E Schumacher, David C Schwebel, James G Scott, Soraya Seedat, Sadaf G Sepanlou, Peter T Serina, Edson E Servan-Mori, Katya A Shackelford, Amira Shaheen, Saeid Shahraz, Teresa Shamah Levy, Siyi Shangguan, Jun She, Sara Sheikhbahaei, Peilin Shi, Kenji Shibuya, Yukito Shinohara, Rahman Shiri, Kawkab Shishani, Ivy Shiue, Mark G Shrime, Inga D Sigfusdottir, Donald H Silberberg, Edgar P Simard, Shireen Sindi, Abhishek Singh, Jasvinder A Singh, Lavanya Singh, Vegard Skirbekk, Erica Leigh Slepak, Karen Sliwa, Samir Soneji, Kjetil Søreide, Sergey Soshnikov, Luciano A Sposato, Chandrashekhar T Sreeramareddy, Jeffrey D Stanaway, Vasiliki Stathopoulou, Dan J Stein, Murray B Stein, Caitlyn Steiner, Timothy J Steiner, Antony Stevens, Andrea Stewart, Lars J Stovner, Konstantinos Stroumpoulis, Bruno F Sunguya, Soumya Swaminathan, Mamta Swaroop, Bryan L Sykes, Karen M Tabb, Ken Takahashi, Nikhil Tandon, David Tanne, Marcel Tanner, Mohammad Tavakkoli, Hugh R Taylor, Braden J Te Ao, Fabrizio Tediosi, Awoke M Temesgen, Tara Templin, Margreet Ten Have, Eric Y Tenkorang, Abdullah S Terkawi, Blake Thomson, Andrew L Thorne-Lyman, Amanda G Thrift, George D Thurston, Taavi Tillmann, Marcello Tonelli, Fotis Topouzis, Hideaki Toyoshima, Jefferson Traebert, Bach X Tran, Matias Trillini, Thomas Truelsen, Miltiadis Tsilimbaris, Emin M Tuzcu, Uche S Uchendu, Kingsley N Ukwaja, Eduardo A Undurraga, Selen B Uzun, Wim H Van Brakel, Steven Van De Vijver, Coen H van Gool, Jim Van Os, Tommi J Vasankari, N Venketasubramanian, Francesco S Violante, Vasiliy V Vlassov, Stein Emil Vollset, Gregory R Wagner, Joseph Wagner, Stephen G Waller, Xia Wan, Haidong Wang, Jianli Wang, Linhong Wang, Tati S Warouw, Scott Weichenthal, Elisabete Weiderpass, Robert G Weintraub, Wang Wenzhi, Andrea Werdecker, Ronny Westerman, Harvey A Whiteford, James D Wilkinson, Thomas N Williams, Charles D Wolfe, Timothy M Wolock, Anthony D Woolf, Sarah Wulf, Brittany Wurtz, Gelin Xu, Lijing L Yan, Yuichiro Yano, Pengpeng Ye, Gökalp K Yentür, Paul Yip, Naohiro Yonemoto, Seok-Jun Yoon, Mustafa Z Younis, Chuanhua Yu, Maysaa E Zaki, Yong Zhao, Yingfeng Zheng, David Zonies, Xiaonong Zou, Joshua A Salomon, Alan D Lopez, Theo Vos
BACKGROUND: The Global Burden of Disease Study 2013 (GBD 2013) aims to bring together all available epidemiological data using a coherent measurement framework, standardised estimation methods, and transparent data sources to enable comparisons of health loss over time and across causes, age-sex groups, and countries. The GBD can be used to generate summary measures such as disability-adjusted life-years (DALYs) and healthy life expectancy (HALE) that make possible comparative assessments of broad epidemiological patterns across countries and time...
November 28, 2015: Lancet
https://www.readbyqxmd.com/read/26234504/superparamagnetic-iron-oxide-nanoparticles-for-direct-labeling-of-stem-cells-and-in-vivo-mri-tracking
#18
Saejeong J Kim, Bobbi Lewis, Mark-Steven Steiner, Ursula V Bissa, Christian Dose, Joseph A Frank
To develop effective stem cell therapies, it is important to track therapeutic cells non-invasively and monitor homing to areas of pathology. The purpose of this study was to design and evaluate the labeling efficiency of commercially available dextran-coated superparamagnetic iron oxide nanoparticles, FeraTrack Direct (FTD), in various stem and immune cells; assess the cytotoxicity and tolerability of the FTD in stem cells; and monitor stem cell homing using FTD-labeled bone-marrow-derived mesenchymal stromal cells (BMSCs) and neural stem cells (NSCs) in a tumor model by in vivo MRI...
January 2016: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/26198606/the-use-and-abuse-of-omnipotence-in-the-journey-of-the-hero
#19
John Steiner
The author uses Joseph Campbell's (1949) account of the "Journey of the Hero" to examine a sequence of stages in which the hero must first use omnipotence in order to embark on an adventure, and then relinquish it in order to return to the ordinary world. The author detects parallels to this theme in descriptions of the fate of Lucifer in Milton's Paradise Lost (1674), and in the development of toddlers as described in Mahler's (1972) observations on separation-individuation. Finally, he traces a similar process in clinical material drawn from near the end of a patient's analysis...
July 2015: Psychoanalytic Quarterly
https://www.readbyqxmd.com/read/25996041/buprenorphine-revisiting-the-efficacy-of-transdermal-delivery-system
#20
REVIEW
Joseph P Kitzmiller, Christopher J Barnett, Nathan S Steiner, Nicoleta Stoicea, Nawal Kamar, Jasmine A Luzum, Eduard Mikulik, Sergio D Bergese
INTRODUCTION: Buprenorphine is a lipid-soluble pharmaceutic used in the management of chronic pain. It is a partial agonist at μ-opioid receptors, an antagonist at κ-opioid receptors, an agonist at δ-opioid receptors and a partial agonist at ORL-1 (nociceptin) receptors. METHODS: An extensive literature search, including Google Scholar and Pubmed database, was conducted. Terms including and associated to 'efficacy of transdermal buprenorphine' were utilized to procure contemporary research articles in order to evaluate and compare the transdermal buprenorphine patch to commonly used traditional pain management medications...
2015: Therapeutic Delivery
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