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Heparin hydrogel sandwich cultures of primary

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https://www.readbyqxmd.com/read/22475531/tissue-specific-synthetic-ecm-hydrogels-for-3-d-in-vitro-maintenance-of-hepatocyte-function
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Aleksander Skardal, Leona Smith, Shantaram Bharadwaj, Anthony Atala, Shay Soker, Yuanyuan Zhang
Despite recent advances in biomaterial science, there is yet no culture system that supports long-term culture expansion of human adult hepatocytes, while preserving continued function. Previous studies suggested that acellular liver extracellular matrix (ECM), employed as a substrate, improved proliferation and function of liver cells. Here we investigated whether extracts prepared from acellular liver ECM (liver ECM extract, LEE), or from whole (fresh) liver tissue (liver tissue extract, LTE), could be combined with collagen Type I, hyaluronic acid (HA), or heparin-conjugated HA (HP) hydrogels to enhance survival and functional output of primary human hepatocytes...
June 2012: Biomaterials
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