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Clearance glomerular filtration rate

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https://www.readbyqxmd.com/read/28077373/determination-of-renal-function-and-injury-using-near-infrared-fluorimetry-in-experimental-cardiorenal-syndrome
#1
Mizuko Ikeda, Rumie Wakasaki, Katie J Schenning, Thomas Swide, Jeong Heon Lee, M Bernie Miller, Hak Soo Choi, Sharon Anderson, Michael P Hutchens
Cardiorenal syndrome type 1 causes acute kidney injury but is poorly understood; animal models and diagnostic aids are lacking. Robust noninvasive measurements of glomerular filtration rate are required for injury models and clinical use. Several have been described but are untested in translational models and suffer from biologic interference. We developed a mouse model of cardiorenal syndrome and tested the novel near-infrared fluorophore, ZW800-1, to assess renal and cardiac function. We performed murine cardiac arrest and cardiopulmonary resuscitation followed by transthoracic echocardiography, 2- and 24h later...
January 11, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28074547/a-pharmacokinetic-and-safety-study-of-trebananib-a-fc-fusion-peptibody-in-patients-with-advanced-solid-tumors-and-varying-degrees-of-renal-dysfunction
#2
Benjamin Wu, Lionel D Lewis, R Donald Harvey, Erik Rasmussen, Erick Gamelin, Yu-Nien Sun, Gregory Friberg, Jay L Koyner, Afshin Dowlati, Michael L Maitland
Clearance of trebananib (AMG 386), a 64 kD anti-angiogenic peptibody, has been associated with estimated glomerular filtration rate (eGFR). We prospectively evaluated trebananib pharmacokinetics and safety/tolerability in advanced solid tumor patients with varying degrees of renal function. Patients were assigned to normal renal function, mild, moderate, or severe renal dysfunction cohorts based on eGFR, received trebananib 15 mg/kg IV weekly, and underwent week 1 and week 5 pharmacokinetic and weekly safety assessments...
January 11, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28070716/pharmacokinetics-and-saturable-absorption-of-gabapentin-in-nursing-home-elderly-patients
#3
Ghada F Ahmed, Sai Praneeth R Bathena, Richard C Brundage, Ilo E Leppik, Jeannine M Conway, Janice B Schwartz, Angela K Birnbaum
Pharmacokinetic data of gabapentin (GBP) in community-dwelling elderly patients show a significant effect of advanced age on GBP pharmacokinetics due to altered renal function. However, there are no data in elderly nursing home (NH) patients to evaluate gabapentin absorption and elimination. Our objective was to characterize the pharmacokinetics of GBP in elderly nursing home patients maintained on GBP therapy. This was a prospective pharmacokinetic study in elderly nursing home patients (≥60 years) receiving GBP for the management of chronic pain or epilepsy from seven nursing homes...
January 9, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28057840/delineating-the-role-of-various-factors-in-renal-disposition-of-digoxin-through-application-of-physiologically-based-kidney-model-to-renal-impairment-populations
#4
Daniel Scotcher, Christopher R Jones, Aleksandra Galetin, Amin Rostami-Hodjegan
Development of sub-models of organs within physiologically-based pharmacokinetic (PBPK) principles and beyond simple perfusion limitations may be challenging because of underdeveloped in vitro-in vivo extrapolation approaches or lack of suitable clinical data for model refinement. However, the advantage of such models in predicting clinical observations in divergent patient groups is now commonly acknowledged. Mechanistic understanding of altered renal secretion in renal impairment is one area that may benefit from such models, despite knowledge gaps in renal pathophysiology (Rowland Yeo et al...
January 5, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28052302/rationale-for-the-evaluation-of-renal-functional-reserve-in-living-kidney-donors-and-recipients-a-pilot-study
#5
Alessandra Spinelli, Aashish Sharma, Gianluca Villa, Sara Samoni, Francesco Ramponi, Alessandra Brocca, Alessandra Brendolan, Stefano Chiaramonte, Giuseppe Castellano, Loreto Gesualdo, Claudio Ronco
BACKGROUND: In living kidney transplantation, preoperative donors' renal functional reserve (RFR) may correlate with postoperative residual renal function in both donors and recipients. The aim of this study was to evaluate the donors' RFR before transplantation and to compare basal and stress renal function before and after transplantation in both donors and recipients. METHODS: Seven pairs of living kidney donors and recipients were considered for this observational study...
January 5, 2017: Nephron
https://www.readbyqxmd.com/read/28031345/identifying-subgroups-of-renal-function-trajectories
#6
Julie Boucquemont, Lucie Loubère, Marie Metzger, Christian Combe, Bénédicte Stengel, Karen Leffondre
BACKGROUND: Renal function in patients with chronic kidney disease (CKD) may follow different trajectory profiles. The aim of this study was to evaluate and illustrate the ability of the latent class linear mixed model (LCMM) to identify clinically relevant subgroups of renal function trajectories within a multicenter hospital-based cohort of CKD patients. METHODS: We analysed data from the NephroTest cohort including 1967 patients with all-stage CKD at baseline who had glomerular filtration rate (GFR) both measured by (51)Cr-EDTA renal clearance (mGFR) and estimated by the CKD-EPI equation (eGFR); 1103 patients had at least two measurements...
December 28, 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28031170/the-influence-of-sex-on-hyperfiltration-in-patients-with-uncomplicated-type-1-diabetes
#7
Marko Škrtić, Yuliya Lytvyn, Petter Bjornstad, Heather N Reich, James W Scholey, Paul M Yip, Etienne B Sochett, Bruce A Perkins, David Z I Cherney
The aim of this analysis was to examine sex-based differences in renal segmental resistances in healthy controls (HC) and patients with type 1 diabetes (T1D). We hypothesized that hyperfiltration - an early hemodynamic abnormality associated with diabetic nephropathy (DN) - would disproportionately affect women with T1D, thereby attenuating protection against the development of renal complications. Glomerular hemodynamic parameters were evaluated in HC (n=30) and in normotensive, normoalbuminuric patients with T1D and either baseline normofiltration (n=36, T1D-N, glomerular filtration rate [GFR] 90-134 ml/min/1...
December 28, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28028385/hplc-estimation-of-iothalamate-to-measure-glomerular-filtration-rate-in-humans
#8
Iltaf Shah, James Barker, Declan P Naughton, Stephen J Barton, Syed Salman Ashraf
Glomerular filtration rate (GFR) is usually determined by estimation of iothalamate (IOT) clearance. We have developed and validated an accurate and robust method for the analysis of IOT in human plasma and urine. The mobile phase consisted of methanol and 50 mM sodium phosphate (10:90; v/v). Flow rate was 1.2 mL/min on a C18 reverse phase column, Synergi-hydro (250 × 4.6 mm) 4 µm 80 Å, with an ultraviolet detector set to 254 nm. Acetonitrile was used for the deproteination and extraction of IOT from human plasma and urine...
2016: Chemistry Central Journal
https://www.readbyqxmd.com/read/28019091/model-based-population-pharmacokinetic-analysis-of-nivolumab-in-patients-with-solid-tumors
#9
G Bajaj, X Wang, S Agrawal, M Gupta, A Roy, Y Feng
Nivolumab is a fully human monoclonal antibody that inhibits programmed death-1 activation. The clinical pharmacology profile of nivolumab was analyzed by a population pharmacokinetics model that assessed covariate effects on nivolumab concentrations in 1,895 patients who received 0.3-10.0 mg/kg nivolumab in 11 clinical trials. Nivolumab pharmacokinetics is linear with a time-varying clearance. A full covariate model was developed to assess covariate effects on pharmacokinetic parameters. Nivolumab clearance and volume of distribution increase with body weight...
December 26, 2016: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/28008457/arterial-hypertension-treated-with-angiotensin-converting-enzyme-inhibitors-and-glucocorticoids-are-independent-risk-factors-associated-with-decreased-glomerular-filtration-rate-in-systemic-sclerosis
#10
Predrag Ostojic, Natasa Stojanovski
The aim of this study was to estimate prevalence and severity of renal insufficiency in systemic sclerosis (SSc) and to assess risk factors associated with reduced glomerular filtration rate (GFR) in SSc patients. Seventy-three consecutive patients with SSc (67 women and 6 men), mean age 56.2 years, mean disease duration 6.7 years, were included in this cross-sectional study. GFR was measured by creatinine clearance (CCr) in all patients, as well as 24-h proteinuria. We assessed frequency and severity of renal insufficiency in our patients with SSc and estimated the association of renal insufficiency with age, disease duration, subtype of the disease, earlier diagnosed arterial hypertension, and medications for which we assumed to affect renal function-cytostatics, nonsteroidal anti-inflammatory drugs, glucocorticoids, ACE inhibitors, diuretics, and calcium channel blockers (CCB)...
December 22, 2016: Rheumatology International
https://www.readbyqxmd.com/read/27999040/population-pharmacokinetics-of-cefazolin-before-during-and-after-cardiopulmonary-bypass-to-optimize-dosing-regimens-for-children-undergoing-cardiac-surgery
#11
Pieter A J G De Cock, Hussain Mulla, Sarah Desmet, Filip De Somer, Brett C McWhinney, Jacobus P J Ungerer, Annelies Moerman, Sabrina Commeyne, Johan Vande Walle, Katrien Francois, Johan G C Van Hasselt, Peter De Paepe
OBJECTIVES: The objective of this study was to characterize cefazolin serum pharmacokinetics in children before, during and after cardiopulmonary bypass (CPB), in order to derive an evidence-based dosing regimen. PATIENTS AND METHODS: This study included children who received cefazolin before surgical incision, before cessation of CPB and after surgery. Blood samples of total and unbound cefazolin concentrations were collected before, during and after CPB. The cefazolin concentration-time profiles were analysed using population pharmacokinetic modelling and predictors for interindividual variability in pharmacokinetic parameters were investigated...
December 20, 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27977591/relationship-between-nephrotoxicity-and-long-term-adefovir-dipivoxil-therapy-for-chronic-hepatitis-b-a-meta-analysis
#12
Qing Luo, Yong Deng, Feifei Cheng, Juan Kang, Shan Zhong, Dazhi Zhang, Weiqiong Zeng
BACKGROUND: To assess the relationship between adefovir dipivoxil and renal function after anti-hepatitis B virus therapy and elucidate the risk factors involved. METHODS: Based on the requirements of the Cochrane systematic review methodology, 21 observational articles on adefovir dipivoxil-associated renal dysfunction were obtained by searching various databases, between January 1, 1995 and July 1, 2016. The Newcastle Ottawa Scale was used to evaluate risk bias...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27974647/dementia-risk-in-renal-dysfunction-a-systematic-review-and-meta-analysis-of-prospective-studies
#13
Kay Deckers, Ileana Camerino, Martin P J van Boxtel, Frans R J Verhey, Kate Irving, Carol Brayne, Miia Kivipelto, John M Starr, Kristine Yaffe, Peter W de Leeuw, Sebastian Köhler
OBJECTIVE: Renal dysfunction has been linked with increased risk for cognitive impairment and dementia, but studies are conflicting. For that reason, the aim of the present systematic review and meta-analysis is to summarize the best available evidence on the prospective association between potential markers of renal dysfunction and development of cognitive impairment or dementia. METHODS: Medline, Embase, and Cochrane Database of Systematic Reviews were searched for potential publications until August 1, 2016...
December 14, 2016: Neurology
https://www.readbyqxmd.com/read/27943221/a-population-pharmacokinetic-model-for-51-cr-edta-to-estimate-renal-function
#14
Isabelle H S Kuan, Stephen B Duffull, Tracey L Putt, John B W Schollum, Robert J Walker, Daniel F B Wright
BACKGROUND AND OBJECTIVES: (51)Cr EDTA clearance (CL) from plasma is used to estimate glomerular filtration rate (GFR). We propose that current methods for analysing the raw (51)Cr EDTA measurements over-simplifies the disposition of (51)Cr EDTA and therefore could produce biased GFR estimates. The aim of this study was to develop a population pharmacokinetic model for (51)Cr EDTA disposition and to compare model-predicted GFR to other methods of estimating renal function. PATIENTS AND METHODS: Data from 40 individuals who received ~7...
December 9, 2016: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/27930558/urinary-%C3%AE-trace-protein-a-unique-biomarker-to-screen-early-glomerular-filtration-rate-impairment
#15
Carlo Donadio, Laura Bozzoli
The screening for chronic kidney disease (CKD) patients needs the measurement of serum markers like creatinine. Our previous results indicated that urinary excretion of β-trace protein (BTP), a low-molecular-weight protein (23-29 kDa), is increased in CKD patients from stage 2. The aim of this study was to assess the major determinants of urinary excretion of BTP and to evaluate its feasibility as noninvasive marker of glomerular filtration rate (GFR) impairment.We studied 355 CKD patients (198 males), aged 15 to 83 years, in stable clinical conditions, classified in the different stages of CKD on the basis of GFR (renal clearance of Tc-diethylenetriamine penta-acetic acid)...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27922734/population-pharmacokinetics-of-ceritinib-in-adult-patients-with-tumors-characterized-by-genetic-abnormalities-in-anaplastic-lymphoma-kinase
#16
Ying Hong, Vanessa Q Passos, Pai-Hsi Huang, Yvonne Y Lau
Ceritinib is a second-generation selective and potent oral anaplastic lymphoma kinase (ALK) inhibitor approved for ALK-positive advanced non-small cell lung cancer previously treated with crizotinib. Population pharmacokinetic (PK) analysis was performed to describe the PK of ceritinib and was used to evaluate the covariate effects on systemic exposure at its label dose (750 mg orally once daily). Ceritinib concentration-time data from 4 clinical studies were described by a 1-compartment model with delayed first-order absorption and time-dependent elimination...
December 6, 2016: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27904871/in-vivo-measurement-and-characterization-of-a-novel-formulation-of-177-lu-dota-octreotate
#17
Dale L Bailey, Thomas M Hennessy, Kathy P Willowson, E Courtney Henry, David Lh Chan, Alireza Aslani, Paul J Roach
OBJECTIVES: Lutetium-177 can be made with high specific activity and with no other isotopes of lutetium present, referred to as "No Carrier Added" (NCA) (177)Lu. We have radiolabelled DOTA-conjugated peptide DOTA-(Tyr(3))-octreotate with NCA (177)Lu ("NCA-LuTATE") and used it in nearly 40 therapeutic administrations for subjects with neuroendocrine tumours or meningiomas. In this paper, we report on our initial studies on aspects of the biodistribution and dosimetry of NCA-LuTATE from gamma camera 2D whole body (WB) and quantitative 3D SPECT (qSPECT) (177)Lu imaging...
2016: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/27894119/trajectories-and-predictors-of-allograft-dysfunction-after-renal-transplantation-in-children
#18
Vandréa Carla de Souza, Muriel Rabilloud, Pierre Cochat, Mario Bernardes Wagner, Clotilde Druck Garcia, Bruno Ranchin, Jean Iwaz, Luciano Selistre, Laurence Dubourg
BACKGROUND: The survival rates of renal transplant children are indeed on the rise, but it is still important to ensure that there is optimal renal function in these children in all their future growing years. The number of functioning nephrons and the graft ability to adapt to an increasing demand during body growth seem to be the most important factors for long-term allograft function. This study examined the long-term change in the glomerular filtration rate in a pediatric kidney transplant cohort and the importance of the recipient and donor ages in predicting transplant outcome...
2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/27890838/preoperative-evaluation-of-the-renal-function-before-the-treatment-of-abdominal-aortic-aneurysms
#19
Raphael Coscas, Sandra Wagner, Eve Vilaine, Albane Sartorius, Isabelle Javerliat, Olivier Goeau-Brissonniere, Marc Coggia, Ziad Massy
OBJECTIVES: Chronic impaired renal function (IRC) constitutes a major risk factor of morbi-mortality during the treatment of an abdominal aortic aneurism (AAA). The inflammatory state due to the AAA could result in a reduction in the muscular mass and an over-estimation of the glomerular filtration rate (GFR) with the usual formulas. The objective of this study was to determine if the formulae used to evaluate the estimated GFR were adapted in patients with AAA. MATERIALS AND METHODS: Between August 2013 and November 2014, we conducted an exploratory study to evaluate the renal function before surgery for AAA in 28 patients...
November 24, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27886861/applicability-of-the-japanese-equation-for-estimating-glomerular-filtration-rate-in-patients-with-advanced-stage-thoracic-cancer
#20
Takashi Kikuchi, Hiroaki Akamatsu, Keita Mori, Ayaka Tanaka, Kuninobu Kanai, Atsushi Hayata, Nahomi Tokudome, Keiichiro Akamatsu, Yasuhiro Koh, Masanori Nakanishi, Hiroki Ueda, Nobuyuki Yamamoto
BACKGROUND: The 24-h creatinine clearance (24-h Ccr) and the Cockcroft-Gault equation (CG) are commonly used as markers of renal function in clinical practice. However, the utility of the Japanese equation for estimating glomerular filtration rate (eGFR) in cancer patients has not yet been evaluated. The aim of this cross-sectional study was to investigate the extent and correlating factors for differences between eGFR and both 24-h Ccr and CG in advanced-stage thoracic cancer patients...
November 2016: Respiratory Investigation
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