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Clearance glomerular filtration rate

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https://www.readbyqxmd.com/read/29774462/combining-gfr-estimates-from-cystatin-c-and-creatinine-what-is-the-optimal-mix
#1
Emil den Bakker, Reinoud Gemke, Joanna A E van Wijk, Isabelle Hubeek, Birgit Stoffel-Wagner, Arend Bökenkamp
BACKGROUND: Combining estimated glomerular filtration rate (eGFR) equations based on creatinine and cystatin C has been shown to improve the accuracy of GFR estimation. This study aims to optimize this strategy for height-independent GFR estimation in children. METHODS: Retrospective study of 408 inulin clearance tests with simultaneous International Federation of Clinical Chemistry-calibrated measurements of creatinine, cystatin C, and urea in children (mean age 12...
May 17, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29772565/safety-of-iohexol-administration-to-measure-glomerular-filtration-rate-in-different-patient-populations-a-25-year-experience
#2
Flavio Gaspari, Surabhi Thakar, Fabiola Carrara, Annalisa Perna, Matias Trillini, Maria Carolina Aparicio, Olimpia Diadei, Silvia Ferrari, Antonio Cannata, Nadia Stucchi, Piero Ruggenenti, Giuseppe Remuzzi, Norberto Perico
BACKGROUND/AIM: In clinical research setting, accurate and precise measurement of glomerular filtration rate (GFR) is essential to overcome the limitations of GFR estimation with equations, which are often unreliable. In recent decades, a method for measuring GFR by plasma clearance of iohexol, a non-ionic radiocontrast agent, was developed. To evaluate the safety of the procedure, we aimed to review all immediate adverse reactions that could be related to iohexol administration in our group's 25 years worth of experience...
May 17, 2018: Nephron
https://www.readbyqxmd.com/read/29768260/carboplatin-dosing-accuracy-by-estimation-of-glomerular-filtration-versus-creatinuria-in-cancer-patients
#3
Noiver Graciano Vera, Luis Pino Villarreal, Jenny Ureña Vargas
BACKGROUND: The glomerular filtration rate (GFR) is essential for calculating the dose and the monitoring of carboplatin. Although GFR measurement (mGFR) by external markers is ideal, in most cases these are not employed; the most used method is GFR estimation (eGFR) by formulae, hence the need to identify the formula with the best performance. METHODS: Patients admitted between 2011 and 2017 and diagnosed with ovarian, endometrial, lung, esophageal, or testicular cancer were assessed retrospectively...
May 16, 2018: Chemotherapy
https://www.readbyqxmd.com/read/29736630/variations-in-clinical-management-of-non-vitamin-k-antagonist-oral-anticoagulants-in-patients-with-atrial-fibrillation-according-to-different-equations-for-estimating-renal-function-post-hoc-analysis-of-a-prospective-cohort
#4
Vincenzo Livio Malavasi, Daniele Pettorelli, Elisa Fantecchi, Cristina Zoccali, Giuliana Laronga, Tommaso Trenti, Gregory Yoke Hong Lip, Giuseppe Boriani
Prescription of non-vitamin K antagonist oral anticoagulants (NOACs) requires an assessment of renal function (RF) and the Cockcroft-Gault (CG) equation is traditionally recommended. The objective of the study was to evaluate the potential changes in NOACs management using different equations for estimating RF. In a post hoc analysis of a prospective cohort of patients with atrial fibrillation, we considered different equations: (1) CG for creatinine clearance (CrCl), (2) modification of diet in renal disease (MDRD), (3) CKD-EPI, (4) Berlin Initiative Study 1 (BIS-1) and (5) full age spectrum (FAS), for glomerular filtration rate (GFR)...
May 7, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29735309/the-elevation-of-circulating-fibroblast-growth-factor-23-without-kidney-disease-does-not-increase-cardiovascular-disease-risk
#5
Eva-Maria Pastor-Arroyo, Nicole Gehring, Christiane Krudewig, Sarah Costantino, Carla Bettoni, Thomas Knöpfel, Sibylle Sabrautzki, Bettina Lorenz-Depiereux, Johanne Pastor, Tim M Strom, Martin Hrabě de Angelis, Giovanni G Camici, Francesco Paneni, Carsten A Wagner, Isabel Rubio-Aliaga
High circulating fibroblast growth factor 23 (FGF23) levels are probably a major risk factor for cardiovascular disease in chronic kidney disease. FGF23 interacts with the receptor FGFR4 in cardiomyocytes inducing left ventricular hypertrophy. Moreover, in the liver FGF23 via FGFR4 increases the risk of inflammation which is also found in chronic kidney disease. In contrast, X-linked hypophosphatemia is characterized by high FGF23 circulating levels due to loss of function mutations of the phosphate-regulating gene with homologies to an endopeptidase on the X chromosome (PHEX), but is not characterized by high cardiovascular morbidity...
May 5, 2018: Kidney International
https://www.readbyqxmd.com/read/29733108/reliability-of-serum-creatinine-based-formulae-estimating-renal-function-in-non-critically-ill-surgery-patients-focus-on-augmented-renal-clearance
#6
Peter Declercq, Matthias Gijsen, Björn Meijers, Marie Schetz, Stefaan Nijs, André D'Hoore, Joost Wauters, Isabel Spriet
WHAT IS KNOWN AND OBJECTIVES: Formulae estimating glomerular filtration rate (GFR) are frequently used to guide drug dosing. The objectives of this prospective single-center study were to evaluate agreement between these equations and measured creatinine clearance (CrCl) in non-critically ill surgery patients with normal kidney function and augmented renal clearance (ARC, CrCl ≥ 130 mL/min/1.73 m²), to determine predictors for disagreement, define a GFR estimator cut-off value identifying ARC and determine the ARC prevalence and duration in non-critically ill surgical patients...
May 7, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29728307/outcome-measures-used-to-report-kidney-function-in-studies-investigating-surgical-management-of-kidney-tumours-a-systematic-review
#7
REVIEW
Robert J Ellis, Yeoungjee Cho, Sharon J Del Vecchio, Megan McStea, Christudas Morais, Jeff S Coombes, Simon T Wood, Glenda C Gobe, Ross S Francis
CONTEXT: Most practice decisions relevant to preserving kidney function in patients managed surgically for kidney tumours are driven by observational studies. A wide range of outcome measures are used in these studies, which reduces comparability and increases the risk of reporting bias. OBJECTIVE: To comprehensively and succinctly describe the outcomes used to evaluate kidney function in studies evaluating surgical management of kidney tumours. EVIDENCE ACQUISITION: Electronic search of the PubMed database was conducted to identify studies with at least one measure of kidney function in patients managed surgically for kidney tumours, published between January 2000 and September 2017...
May 1, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29724188/the-effect-of-spironolactone-on-calcineurin-inhibitor-induced-nephrotoxicity-a-multicenter-randomized-double-blind-clinical-trial-the-spiren-trial
#8
Line Aas Mortensen, Helle C Thiesson, Birgitte Tougaard, Martin Egfjord, Anne Sophie Lind Fischer, Claus Bistrup
BACKGROUND: Calcineurin inhibitor induced nephrotoxicity contributes to late allograft failure in kidney transplant patients. Evidence points towards aldosterone to play a role in the development of fibrosis in multiple organs. Animal studies have indicated a beneficial effect of mineralocorticoid receptor antagonists preventing calcineurin inhibitor induced nephrotoxicity. Only few studies have explored this effect in humans. The objective of this study is to evaluate the effect of spironolactone on glomerular filtration rate and fibrosis in kidney transplant patients...
May 3, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29719337/the-impact-of-stone-composition-on-renal-function
#9
Anmar Nassir, Hesham Saada, Taghreed Alnajjar, Jomanah Nasser, Waed Jameel, Soha Elmorsy, Hattan Badr
Background: Nephrolithiasis is a common condition that has various classifications according to stone composition. Stone formation can affect renal function; it can be a strong risk factor for chronic kidney disease (CKD). The main objective of this study is to explore the association between creatinine clearance and different stone compositions. Methods: This is a retrospective cohort study conducted in a tertiary center in Jeddah, Saudi Arabia, between 2005 and 2014...
April 2018: Urology Annals
https://www.readbyqxmd.com/read/29700802/acute-and-chronic-effects-of-metabolic-acidosis-on-renal-function-and-structure
#10
Gennaro Tammaro, Miriam Zacchia, Enrica Zona, Enza Zacchia, Giovambattista Capasso
BACKGROUND: Emerging evidence suggests that chronic metabolic acidosis (CMA) may have significant implications in terms of worsening renal disease in CKD patients, but the effect of CMA on renal function and structure has not been fully elucidated. METHOD: We studied the acute and chronic consequences of an acid load (AL) on glomerular filtration rate (GFR) and renal histology in C57BL/6 mice. FITC-inulin clearance was performed at several time points; markers of renal fibrosis were studied at mRNA and protein levels; finally, kidney expression of candidate molecules triggering changes in renal function was studied...
April 26, 2018: Journal of Nephrology
https://www.readbyqxmd.com/read/29696241/blood-pressure-and-metabolic-effects-of-acetyl-l-carnitine-in-type-2-diabetes-diabasi-randomized-controlled-trial
#11
Aneliya Parvanova, Matias Trillini, Manuel A Podestà, Ilian P Iliev, Carolina Aparicio, Annalisa Perna, Francesco Peraro, Nadia Rubis, Flavio Gaspari, Antonio Cannata, Silvia Ferrari, Antonio C Bossi, Roberto Trevisan, Sreejith Parameswaran, Jonathan S Chávez-Iñiguez, Fahrudin Masnic, Sidy Mohamed Seck, Teerayuth Jiamjariyaporn, Monica Cortinovis, Luca Perico, Kanishka Sharma, Giuseppe Remuzzi, Piero Ruggenenti, David G Warnock
Context: Acetyl-l-carnitine (ALC), a mitochondrial carrier involved in lipid oxidation and glucose metabolism, decreased systolic blood pressure (SBP), and ameliorated insulin sensitivity in hypertensive nondiabetic subjects at high cardiovascular risk. Objective: To assess the effects of ALC on SBP and glycemic and lipid control in patients with hypertension, type 2 diabetes mellitus (T2D), and dyslipidemia on background statin therapy. Design: After 4-week run-in period and stratification according to previous statin therapy, patients were randomized to 6-month, double-blind treatment with ALC or placebo added-on simvastatin...
May 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29692931/the-reliability-of-the-use-of-serum-neutrophil-gelatinase-associated-lipocalin-levels-in-the-assessment-of-renal-functions-after-coronary-artery-bypass-grafting
#12
Ozan Onur Balkanay, Deniz Göksedef, Suat Nail Ömeroğlu, Gökhan İpek
Objective: Evaluation of perioperative renal function is very important for early diagnosis and treatment of acute kidney injury after coronary artery bypass grafting. Serum creatinine levels, creatinine clearance, and estimated glomerular filtration rates used in determination of postoperative kidney injury can lead to late detection. Therefore, it is necessary to make a diagnosis earlier in clinical practice and to search for a reliable method. The reliability of the use of serum neutrophil gelatinase-associated lipocalin levels in close follow-up of renal function was evaluated in patients with coronary artery bypass grafting under cardiopulmonary bypass in our study...
2018: Cardiology Research and Practice
https://www.readbyqxmd.com/read/29690893/inclusion-and-definition-of-acute-renal-dysfunction-in-critically-ill-patients-in-randomized-controlled-trials-a-systematic-review
#13
Rogerio da Hora Passos, Joao Gabriel Rosa Ramos, André Gobatto, Juliana Caldas, Etienne Macedo, Paulo Benigno Batista
BACKGROUND: In evidence-based medicine, multicenter, prospective, randomized controlled trials (RCTs) are the gold standard for evaluating treatment benefits and ensuring the effectiveness of interventions. Patient-centered outcomes, such as mortality, are most often the preferred evaluated outcomes. While there is currently agreement on how to classify renal dysfunction in critically ill patients , the application frequency of this new classification system in RCTs has not previously been evaluated...
April 24, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29686132/application-of-prescribing-recommendations-in-older-people-with-reduced-kidney-function-a-cross-sectional-study-in-general-practice
#14
Su Wood, Duncan Petty, Liz Glidewell, Dk Theo Raynor
BACKGROUND: Kidney function reduces with age, increasing the risk of harm from increased blood levels of many medicines. Although estimated glomerular filtration rate (eGFR) is reported for prescribing decisions in those aged ≥65 years, creatinine clearance (Cockcroft-Gault) gives a more accurate estimate of kidney function. AIM: To explore the extent of prescribing outside recommendations for people aged ≥65 years with reduced kidney function in primary care and to assess the impact of using eGFR instead of creatinine clearance to calculate kidney function...
May 2018: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/29684175/aminoglycoside-exposure-and-renal-function-before-lung-transplantation-in-adult-cystic-fibrosis-patients
#15
Etienne Novel-Catin, Solenne Pelletier, Quitterie Reynaud, Raphaele Nove-Josserand, Stephane Durupt, Laurence Dubourg, Isabelle Durieu, Denis Fouque
Background: Patients with cystic fibrosis (CF) are at risk of kidney injury even before undergoing lung transplantation, because of prolonged exposure to aminoglycosides (AGs), chronic dehydration and complications of diabetes mellitus. The usual equations estimating the glomerular filtration rate (GFR), such as Cockcroft-Gault and Modification of Diet in Renal Disease, are not adapted to the CF population due to patients' low body weight and reduced muscle mass. The aim of this study was to precisely measure GFR in adult CF patients and to see whether repeated AG treatment would impair renal function before lung transplantation...
April 18, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29657939/cisplatin-alters-sodium-excretion-and-renal-clearance-in-rats-gender-and-drug-dose-related
#16
Sima Jilanchi, Ardeshir Talebi, Mehdi Nematbakhsh
Background: Nephrotoxicity is one of the side effects of cisplatin (CP) therapy which is gender related. CP disturbs renal function through glomerular filtration rate and electrolytes transport disturbances. This study was designed to compare some markers related to renal function in two protocols of CP treatment in rats. Materials and Methods: Male and female rats were subjected to receive single (treat 1; 7.5 mg/kg) and continues doses (treat 2; 3 mg/kg/day for 5 days) of CP, and the measurements were compared with control animals...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29620614/reduced-access-to-liver-transplantation-in-women-role-of-height-meld-exception-scores-and-renal-function-underestimation
#17
Alina M Allen, Julie K Heimbach, Joseph J Larson, Kristin C Mara, W Ray Kim, Patrick S Kamath, Terry M Therneau
BACKGROUND: Sex-based disparities in liver transplantation (LT) are incompletely understood. We assessed the role of height, MELD, MELD-Na and exception points in the disparate access to LT. METHODS: Adults waitlisted for LT at Organ Procurement and Transplantation Network (OPTN) between 2002 and 2013 were included. Covariates associated with likelihood of LT were analyzed by Cox proportional model. In a separate cohort of waitlisted adults with glomerular filtration rate (GFR) measurement by iothalamate clearance (n=611), we determined the number of creatinine-derived MELD points in men vs women, across all ranges of GFR...
April 3, 2018: Transplantation
https://www.readbyqxmd.com/read/29602293/swimming-exercise-demonstrates-advantages-over-running-exercise-in-reducing-proteinuria-and-glomerulosclerosis-in-spontaneously-hypertensive-rats
#18
N L Totou, S S Moura, D B Coelho, E C Oliveira, L K Becker, W G Lima
Experimental studies in animal models have described the benefits of physical exercise (PE) to kidney diseases associated with hypertension. Land- and water-based exercises induce different responses in renal function. Our aim was to evaluate the renal alterations induced by different environments of PE in spontaneously hypertensive rats (SHRs). The SHRs were divided into sedentary (S), swimming exercise (SE), and running exercise (RE) groups, and were trained for 8 weeks under similar intensities (60 min/day)...
March 1, 2018: Physiology International
https://www.readbyqxmd.com/read/29594677/monitoring-of-gentamicin-serum-concentrations-in-obstetrics-and-gynaecology-patients-in-namibia
#19
Bonifasius S Singu, Mwangana Mubita, Moses M Thikukutu, Josef K Mufenda, Shonag B McKenzie, Roger K Verbeeck
Background Therapeutic drug monitoring is frequently used to optimize the gentamicin dose. Objective The study investigated whether a 240 mg once daily standard dose achieves the recommended target serum gentamicin concentrations. Setting The prospective, observational study took place in the 2 major public hospitals in Namibia. Method Twenty-nine female patients receiving a standard dose (240 mg gentamicin once daily) participated in the study. Two blood samples were withdrawn to estimate gentamicin pharmacokinetic parameters...
March 28, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29587296/the-relationships-of-the-fractional-excretion-of-uric-acid-with-brachial-ankle-pulse-wave-velocity-and-ankle-brachial-index-in-chinese-young-adults
#20
Jia-Wen Hu, Yang Wang, Chao Chu, Yu Yan, Keke Wang, Wenling Zheng, Qiong Ma, Yong-Bo Lv, Yin Deng, Bo Yan, Jian-Jun Mu
BACKGROUND/AIMS: Elevated serum uric acid (UA) was intimately correlated with vascular stiffness and abnormal ankle brachial index (ABI) in various populations. These correlations lost significance after adjustment for estimated glomerular filtration rate (eGFR), indicating that the association of UA and brachial-ankle pulse wave velocity (baPWV) or ABI might be driven by kidney function. UA is predominantly eliminated through the kidneys, and metabolic disorders can influence the clearance of UA...
2018: Kidney & Blood Pressure Research
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